WO1999020287A1 - The use of an aqueous solution in the preparation of a medicament for use in the treatment of live animals - Google Patents

The use of an aqueous solution in the preparation of a medicament for use in the treatment of live animals Download PDF

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Publication number
WO1999020287A1
WO1999020287A1 PCT/US1998/022372 US9822372W WO9920287A1 WO 1999020287 A1 WO1999020287 A1 WO 1999020287A1 US 9822372 W US9822372 W US 9822372W WO 9920287 A1 WO9920287 A1 WO 9920287A1
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WO
WIPO (PCT)
Prior art keywords
solution
composition
aqueous solution
electro
anion
Prior art date
Application number
PCT/US1998/022372
Other languages
French (fr)
Inventor
Gilbert Theo Hinze
Original Assignee
Radical Waters Ip (Pty) Ltd
Davis, Joanne, T.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Radical Waters Ip (Pty) Ltd, Davis, Joanne, T. filed Critical Radical Waters Ip (Pty) Ltd
Priority to AU12733/99A priority Critical patent/AU1273399A/en
Priority to EP98956145A priority patent/EP1047435A4/en
Publication of WO1999020287A1 publication Critical patent/WO1999020287A1/en
Priority to US11/652,199 priority patent/US7651704B2/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/08Oxides; Hydroxides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/20Elemental chlorine; Inorganic compounds releasing chlorine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/40Peroxides

Definitions

  • This invention relates to the use of an aqueous solution in the preparation of
  • sheep, cattle, goats, pigs, chickens, ostriches to include within its meaning sheep, cattle, goats, pigs, chickens, ostriches,
  • pathogen should be construed to include within
  • micro-organisms makes anti-microbials ineffective.
  • composition comprising an
  • composition comprising an
  • the anion-containing aqueous solution being substantially as herein defined.
  • the anion-containing aqueous solution may be prepared by means of
  • the salt may be sodium chloride.
  • anion-containing solution and the associated cation-containing solution may be non-iodated sodium chloride or potassium chloride.
  • the electro-chemical reactor may include a through flow, electro-chemical cell
  • the anion-containing solution is referred to hereinafter for brevity as the
  • anolyte solution and the cation-containing solution is referred to hereinafter
  • the anolyte solution may be produced from an aqueous NaCl solution,
  • radical species may be labile and after about 96 hours, the various radical species may be labile and after about 96 hours, the various radical species may be labile and after about 96 hours, the various radical species may be labile and after about 96 hours, the various radical species may be labile and after about 96 hours, the various radical species may be labile and after about 96 hours, the various radical species may be labile and after about 96 hours, the various radical species may be labile and after about 96 hours, the various radical species may
  • the anolyte solution may have a pH of about 6,5 to 7,5.
  • the anolyte solution may have a pH of about 6,5 to 7,5.
  • CIO CIO
  • CIO CIO
  • HCIO OH
  • the redox potential of the anolyte solution may be monitored during the
  • the catholyte solution generally may have a pH of up to about 12-13 and a
  • the catholyte solution may include species
  • the method of treatment may include administering the anolyte solution by
  • anolyte solution as an inhalant via an atomising or fogging process
  • drinking water are both suitable for animals such as weaner piglets and chicklets which are susceptible to stress and accompanying weight loss.
  • atomising or fogging process may include the step of atomising the solution
  • the method may include the preliminary step of
  • the atomising or fogging process is preferably conducted at pre-determined
  • the anolyte solution may also be applied by an atomising process in air
  • the treatment of the animal as described above may be conducted so as to
  • the oxidising-free radicals present in the anolyte solution may act
  • the anolyte solution may have a specific anion concentration and distribution
  • the pathogenic micro-organisms to be treated may include enteric pathogenic
  • micro-organisms and respiratory pathogenic micro-organisms.
  • An electro-chemical reactor including a through flow, electro-chemical cell
  • analytic chamber was used to produce anolyte and catholyte solutions.
  • the anolyte solution was added to the drinking water of the weaner piglets
  • the administered groups showed relative weight gain relative to the
  • anolyte solution as measured by the oxidation-reduction potential (ORP) or
  • exposure time i.e. the contact time between the contaminated animal and the
  • the available free radical concentration can be monitored.

Abstract

This invention relates to a composition for use in the treatment of pathogenic microorganisms in a live animal, the composition comprising an electro-chemically activated, anion-containing aqueous solution.

Description

THE USE OF AN AQUEOUS SOLUTION IN THE PREPARATION OF A MEDICAMENT FOR USE IN THE TREATMENT OF LIVE ANIMALS
Field of the Invention :
This invention relates to the use of an aqueous solution in the preparation of
a medicament for use in the treatment of live animals.
Background to the Invention :
For the purposes of this specification, the term "animal" should be construed
to include within its meaning sheep, cattle, goats, pigs, chickens, ostriches,
reptiles and the like; the term "disease" should be construed to include within
its meaning diarrhoea; the term pathogen should be construed to include within
its meaning micro-organisms such as E-coli; and the term "medicament"
should be construed to include within its meaning oral bactericides and
bactericidal inhalants. The Applicant envisages that the invention will be
applicable particularly, but not exclusively, in the preparation of a medicament
for use in the treatment of pathogenic micro-organisms in weaner piglets and
chicklets.
The presence of antibiotic residues in food products lead to allergic and
anaphylactic reactions in humans. The development of resistant strains of
micro-organisms makes anti-microbials ineffective.
Object of the Invention ;
It is accordingly an object of the mvention to provide inexpensive, novel and
alternative anti-microbials that overcome the above disadvanta ges. In accordance with a first aspect of the invention, there is provided the use of
a composition in the preparation of a medicament for use in the treatment of
pathogenic micro-organisms in a live animal, the composition comprising an
electro-chemically activated anion-containing aqueous solution.
In accordance with a second aspect of the invention there is provided a
composition in the preparation of a medicament for the treatment of
pathogenic micro-organisms in live animals, the composition comprising an
electro-chemically activated anion-containing aqueous solution, the composition
substantially as herein defined.
In accordance with a third aspect of the invention there is provided a method
of treating pathogenic micro-organisms in a live animal, the method
including the step of administering a dosage of a composition comprising an
electro-chemically activated anion-containing aqueous solution to the animal,
the anion-containing aqueous solution being substantially as herein defined.
The anion-containing aqueous solution may be prepared by means of
electrolysis of an aqueous solution of a salt. The salt may be sodium chloride.
In particular, it may be non-iodated sodium chloride or potassium chloride. The anion-containing solution and the associated cation-containing solution
may be produced by an electro-chemical reactor or so-called electrolysis
device.
The electro-chemical reactor may include a through flow, electro-chemical cell
having two co-axial cylindrical electrodes with a co-axial diaphragm between
the electrodes so as to separate an annular inter electrode space into a catalytic
and an analytic chamber.
The anion-containing solution is referred to hereinafter for brevity as the
"anolyte solution" and the cation-containing solution is referred to hereinafter
for brevity as the "catholyte solution".
The anolyte solution may be produced from an aqueous NaCl solution,
electrolysed to produce radical cation and radical anion species, the anolyte
solution having a redox potential up to about + 600 mV to + 800 mV. These
species may be labile and after about 96 hours, the various radical species may
disappear with no residues being produced.
The anolyte solution may have a pH of about 6,5 to 7,5. The anolyte solution
may include species such as CIO; CIO" ; HCIO; OH" ; H02- ; H202 ; 03 ;
Figure imgf000005_0001
These species have been found to have a synergistic anti-bacterial and/or anti¬
viral effect which is generally stronger than that of chemical bactericides and
has been found to be particularly effective against viral organisms and spore
and cyst forming bacteria.
The redox potential of the anolyte solution may be monitored during the
process so that the treatment process may be monitored and controlled on a
continuous basis.
The catholyte solution generally may have a pH of up to about 12-13 and a
redox potential of about -980 mV. The catholyte solution may include species
such as NaOH; KOH; CA(OH)2 ; Mg (OH)2 ; HO" ; H3O2 - ; HO2- ; H202-;
O2- ; OH"; O2 2- .
The method of treatment may include administering the anolyte solution by
soaking, rinsing or dipping the animal in the anolyte solution, applying the
anolyte solution as an inhalant via an atomising or fogging process or
administering the anolyte solution orally. The soaking, rinsing or dipping
process is suitable for animals which can be handled with relative ease.
The processes of atomising or fogging and oral administration by addition to
drinking water are both suitable for animals such as weaner piglets and chicklets which are susceptible to stress and accompanying weight loss. The
atomising or fogging process may include the step of atomising the solution
into the atmosphere in a volume to be treated, forming droplets of between 5
and 100 micrometre. The method may include the preliminary step of
enclosing the volume to be treated prior to atomising or fogging the enclosed
volume.
The atomising or fogging process is preferably conducted at pre-determined
intervals so as to maintain a suitable level of anolyte concentration in the
atmosphere, thus utilising the optimum microcidal and other properties of the
anolyte solution in accordance with the required administration rate.
The anolyte solution may also be applied by an atomising process in air
ducting systems to destroy air-bome micro-organisms and to destroy micro¬
organisms present in the airways and lung tissue by inhalation.
The treatment of the animal as described above may be conducted so as to
improve the weight gain as a result of the anti-microbial action of the anolyte
solution.
The oxidising-free radicals present in the anolyte solution may act
synergistically at a bacterial cellular level. The anolyte solution may have a specific anion concentration and distribution
and a redox potential in accordance with the specific application.
The pathogenic micro-organisms to be treated may include enteric pathogenic
micro-organisms and respiratory pathogenic micro-organisms.
Detailed Description of the Invention :
A preferred embodiment of the invention will now be described with reference
to the accompanying experiments.
In a series of experiments, the bactericidal effect of the anolyte solution was
tested on animals. The results are reflected in the tables below.
An electro-chemical reactor, including a through flow, electro-chemical cell
having two co-axial cylindrical electrodes with a co-axial diaphragm between
them so as to separate an annular inter-electrode space into a catalytic and an
analytic chamber, was used to produce anolyte and catholyte solutions.
Experiment 1 - Weaner Piglets
The anolyte solution was added to the drinking water of the weaner piglets
over a period of 14 days and the results were measured in terms of average weight after the 14 day period. The average weight of the administered groups
were compared with the average weight of the unadministered groups.
The administered groups showed relative weight gain relative to the
unadministered groups. The relative weight gains of the administered groups
are reflected in Table 1 below.
Experiment 2 - Broilers (Chicklets)
Day old broilers were administered with anolyte solution (10% diluted) by
addition to drinking water for 7 days. (Group C3 - 12 000 chicklets). No
antibiotic medication was administered during that time. Untreated control
groups (Cl, C2, C4 and C5 = total 48 000 chicklets) received normal drinking
water during that time. The untreated groups were routinely medicated with
Tylosin for 3 consecutive days.
Bacterial analyses of the drinking water of all groups were regularly conducted
during the first 7 days. Other measurements included daily mortalities and
morbidities throughout and pH and ORP determinations of the drinking water
during the first 7 days. All results are reflected in Table 2 below.
Medication of drinking water with anolyte solution supplied to day-old chicklets for the first period resulted in a significant reduction in mortalities
throughout the growth and finishing period. Mortalities increased in all the
groups from the 4th week onwards mainly due to respiratory disease. It is
envisaged that these could be reduced by fogging the environment with anolyte
solution to eliminate airborne respiratory pathogens by means of respiratory
intake.
It has been found that the efficacy of the use of the anolyte solution in the
treatment of live animals depends upon the concentration of the anions in the
anolyte solution, as measured by the oxidation-reduction potential (ORP) or
redox potential of the anolyte solution, the flow rate through the reactor, the
exposure time, i.e. the contact time between the contaminated animal and the
anolyte solution and the temperature during application. By measuring the
redox potential of the anolyte solution during the treatment, for example, of
a weaner piglet, the available free radical concentration can be monitored.
Anolyte solution has been found to be more effective at lower than at higher
temperatures.
It will be appreciated that many variations in detail are possible without
departing from the scope and/or spirit of the invention as claimed in the claims
hereinafter.

Claims

1. The use of a composition in the preparation of a medicament for use in
the treatment of pathogenic micro-organisms in a live animal, the
composition comprising an electro-chemically activated, anion-
containing aqueous solution.
2. A composition for the preparation of a medicament for the treatment of
pathogenic micro-organisms in live animals, the composition comprising
an electro-chemically activated anion-containing aqueous solution.
3. A method of treating pathogenic micro-organisms in a live animal, the
method including the step of administering a dosage of a composition
comprising an electro-chemically activated anion-containing aqueous
solution to the animal
4. A composition as claimed in claim 2 wherein the anion-containing
aqueous solution is prepared by means of electrolysis of an aqueous
solution of a salt.
A composition as claimed in claim 2 wherein the anion-containing
solution is produced by an electro-chemical reactor, the electro-chemical reactor including a through flow, electro-chemical cell having two co¬
axial cylindrical electrodes with a co-axial diaphragm between the
electrodes so as to separate an annular inter electrode space into a
catalytic and an analytic chamber.
6. A composition as claimed in claim 2 wherein the anion containing
aqueous solution has a redox potential up to about ÷600 mV and 800
mV and a pH of about 6,5 to 7,5.
7. A method of treatment as claimed in claim 3 including at least one of
the steps of administering the solution by soaking, rinsing or dipping the
animal in the solution, applying the solution as an inhalant via an
atomising or fogging process, and administering the solution orally.
8. A method as claimed in claim 7 wherein the atomising or fogging
process includes the step of atomising the solution into the atmosphere
in a volume to be treated, forming droplets of between 5 and 100
micrometre..
PCT/US1998/022372 1997-10-23 1998-10-23 The use of an aqueous solution in the preparation of a medicament for use in the treatment of live animals WO1999020287A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU12733/99A AU1273399A (en) 1997-10-23 1998-10-23 The use of an aqueous solution in the preparation of a medicament for use in thetreatment of live animals
EP98956145A EP1047435A4 (en) 1997-10-23 1998-10-23 The use of an aqueous solution in the preparation of a medicament for use in the treatment of live animals
US11/652,199 US7651704B2 (en) 1997-10-23 2007-01-11 Use of an aqueous solution in the treatment of live animals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA979486 1997-10-23
ZA97/9486 1998-10-23

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09529734 A-371-Of-International 2000-06-19
US10/679,449 Continuation-In-Part US20040131695A1 (en) 1997-10-23 2003-10-07 Use of an aqueous solution in the treatment of live animals

Publications (1)

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WO1999020287A1 true WO1999020287A1 (en) 1999-04-29

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WO (1) WO1999020287A1 (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003045446A1 (en) * 2001-10-12 2003-06-05 Radical Waters (Ip) (Pty) Limited Method for the management and/or treatment of microbially contaminated environments and the use of a new class of microbicidal reagents in such management
WO2003049749A1 (en) * 2001-12-10 2003-06-19 Radical Waters (Ip) (Pty) Limited Treatment of dairy cattle through use of electrochemically activated, aqueous solutions
WO2003050044A1 (en) * 2001-12-10 2003-06-19 Radical Waters (Ip) (Pty) Limited Electrochemically activated water for the treatment of cystitis
WO2003049750A1 (en) * 2001-12-10 2003-06-19 Radical Waters (Ip) (Pty) Limited Method for treating infectious conditions of mucosae and muco-cutaneous tissue
WO2005089426A2 (en) * 2004-03-17 2005-09-29 Medical Discoveries, Inc. Method of treating sepsis
WO2005113026A2 (en) * 2004-04-22 2005-12-01 Medical Discoveries, Inc. Method of treating respiratory disorders and airway inflammation
US7651704B2 (en) 1997-10-23 2010-01-26 Radical Waters Ip (Pty) Ltd. Use of an aqueous solution in the treatment of live animals
US8123865B2 (en) 2007-03-19 2012-02-28 Gb International Ltd. Method and composition for starch extraction and modification
US8147889B2 (en) 2007-01-12 2012-04-03 Giant Trading Inc. Method for treating raw and processed grains and starches
WO2012064272A1 (en) * 2010-11-12 2012-05-18 Anolytech Ab Washing composition for domestic milking animals
CN103249680A (en) * 2010-10-28 2013-08-14 阿诺来泰克公司 Process and system for producing an anolyte fraction

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7651704B2 (en) 1997-10-23 2010-01-26 Radical Waters Ip (Pty) Ltd. Use of an aqueous solution in the treatment of live animals
WO2003045446A1 (en) * 2001-10-12 2003-06-05 Radical Waters (Ip) (Pty) Limited Method for the management and/or treatment of microbially contaminated environments and the use of a new class of microbicidal reagents in such management
WO2003049750A1 (en) * 2001-12-10 2003-06-19 Radical Waters (Ip) (Pty) Limited Method for treating infectious conditions of mucosae and muco-cutaneous tissue
WO2003050044A1 (en) * 2001-12-10 2003-06-19 Radical Waters (Ip) (Pty) Limited Electrochemically activated water for the treatment of cystitis
WO2003049749A1 (en) * 2001-12-10 2003-06-19 Radical Waters (Ip) (Pty) Limited Treatment of dairy cattle through use of electrochemically activated, aqueous solutions
WO2005089426A2 (en) * 2004-03-17 2005-09-29 Medical Discoveries, Inc. Method of treating sepsis
WO2005089426A3 (en) * 2004-03-17 2009-04-16 Medical Discoveries Inc Method of treating sepsis
WO2005113026A2 (en) * 2004-04-22 2005-12-01 Medical Discoveries, Inc. Method of treating respiratory disorders and airway inflammation
US20060073212A1 (en) * 2004-04-22 2006-04-06 Palmer Craig R Method of treating respiratory disorders and airway inflammation
WO2005113026A3 (en) * 2004-04-22 2007-07-12 Medical Discoveries Inc Method of treating respiratory disorders and airway inflammation
US8147889B2 (en) 2007-01-12 2012-04-03 Giant Trading Inc. Method for treating raw and processed grains and starches
US8123865B2 (en) 2007-03-19 2012-02-28 Gb International Ltd. Method and composition for starch extraction and modification
CN103249680A (en) * 2010-10-28 2013-08-14 阿诺来泰克公司 Process and system for producing an anolyte fraction
WO2012064272A1 (en) * 2010-11-12 2012-05-18 Anolytech Ab Washing composition for domestic milking animals

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Publication number Publication date
EP1047435A1 (en) 2000-11-02
AU1273399A (en) 1999-05-10
EP1047435A4 (en) 2001-03-21

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