WO1999015540A3 - Verfahren zur herstellung eines pentopyranosyl-nucleosids - Google Patents

Verfahren zur herstellung eines pentopyranosyl-nucleosids Download PDF

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Publication number
WO1999015540A3
WO1999015540A3 PCT/EP1998/005998 EP9805998W WO9915540A3 WO 1999015540 A3 WO1999015540 A3 WO 1999015540A3 EP 9805998 W EP9805998 W EP 9805998W WO 9915540 A3 WO9915540 A3 WO 9915540A3
Authority
WO
WIPO (PCT)
Prior art keywords
producing
pentopyranosyl nucleoside
pentopyranosyl
nucleoside
formula
Prior art date
Application number
PCT/EP1998/005998
Other languages
English (en)
French (fr)
Other versions
WO1999015540A2 (de
Inventor
Christian Miculka
Norbert Windhab
Tilmann Brandstetter
Gerhard Burdinski
Original Assignee
Aventis Res & Tech Gmbh & Co
Christian Miculka
Norbert Windhab
Tilmann Brandstetter
Gerhard Burdinski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Res & Tech Gmbh & Co, Christian Miculka, Norbert Windhab, Tilmann Brandstetter, Gerhard Burdinski filed Critical Aventis Res & Tech Gmbh & Co
Priority to JP2000512845A priority Critical patent/JP4601817B2/ja
Priority to US09/509,010 priority patent/US6613894B1/en
Priority to CA002302414A priority patent/CA2302414A1/en
Priority to AT98950062T priority patent/ATE233272T1/de
Priority to EP98950062A priority patent/EP1019423B1/de
Priority to BR9812501-0A priority patent/BR9812501A/pt
Priority to AU96271/98A priority patent/AU751058B2/en
Priority to KR1020007002982A priority patent/KR20010024202A/ko
Priority to DE59807330T priority patent/DE59807330D1/de
Publication of WO1999015540A2 publication Critical patent/WO1999015540A2/de
Publication of WO1999015540A3 publication Critical patent/WO1999015540A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/724—Devices having flexible or movable element
    • Y10S977/727—Devices having flexible or movable element formed from biological material
    • Y10S977/728—Nucleic acids, e.g. DNA or RNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/797—Lipid particle
    • Y10S977/798—Lipid particle having internalized material
    • Y10S977/799—Containing biological material
    • Y10S977/80—Nucleic acid, e.g. DNA or RNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
    • Y10S977/835—Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial
    • Y10S977/836—Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial having biological reactive capability
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/894—Manufacture, treatment, or detection of nanostructure having step or means utilizing biological growth
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    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/895—Manufacture, treatment, or detection of nanostructure having step or means utilizing chemical property
    • Y10S977/896—Chemical synthesis, e.g. chemical bonding or breaking
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    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
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    • Y10S977/915—Therapeutic or pharmaceutical composition
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    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/925—Bioelectrical

Abstract

Die Erfindung betrifft ein Pentopyranosyl-Nucleosid der Formel (I) oder der Formel (II), deren Herstellung und Verwendung zur Herstellung eines Therapeutikums, Diagnostikums und/oder elektronischen Bauteils.
PCT/EP1998/005998 1997-09-22 1998-09-21 Verfahren zur herstellung eines pentopyranosyl-nucleosids WO1999015540A2 (de)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2000512845A JP4601817B2 (ja) 1997-09-22 1998-09-21 ペントピラノシルヌクレオシドの製造方法
US09/509,010 US6613894B1 (en) 1997-09-22 1998-09-21 Method for producing a pyranosyl nucleic acid conjugate
CA002302414A CA2302414A1 (en) 1997-09-22 1998-09-21 Process for the preparation of a pentopyranosylnucleoside
AT98950062T ATE233272T1 (de) 1997-09-22 1998-09-21 Verfahren zur herstellung eines pentopyranosyl- nucleosids
EP98950062A EP1019423B1 (de) 1997-09-22 1998-09-21 Verfahren zur herstellung eines pentopyranosyl-nucleosids
BR9812501-0A BR9812501A (pt) 1997-09-22 1998-09-21 Processo para a preparação de um pentopiranosilnucleosìdeo
AU96271/98A AU751058B2 (en) 1997-09-22 1998-09-21 Method for producing a pentopyranosyl nucleoside
KR1020007002982A KR20010024202A (ko) 1997-09-22 1998-09-21 펜토피라노실 뉴클레오사이드의 제조방법
DE59807330T DE59807330D1 (de) 1997-09-22 1998-09-21 Verfahren zur herstellung eines pentopyranosyl-nucleosids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19741715A DE19741715A1 (de) 1997-09-22 1997-09-22 Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19741715.9 1997-09-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/654,274 Continuation US20050053945A1 (en) 1997-09-22 2003-09-02 Process for the preparation of a pentopyranosyl conjugate

Publications (2)

Publication Number Publication Date
WO1999015540A2 WO1999015540A2 (de) 1999-04-01
WO1999015540A3 true WO1999015540A3 (de) 1999-06-10

Family

ID=7843183

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/EP1998/005998 WO1999015540A2 (de) 1997-09-22 1998-09-21 Verfahren zur herstellung eines pentopyranosyl-nucleosids
PCT/EP1998/005999 WO1999015541A2 (de) 1997-09-22 1998-09-21 Verwendung eines pentopyranosyl-nucleosids zur herstellung eines elektronischen bauteils sowie konjugate davon
PCT/EP1998/005997 WO1999015539A2 (de) 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/EP1998/005999 WO1999015541A2 (de) 1997-09-22 1998-09-21 Verwendung eines pentopyranosyl-nucleosids zur herstellung eines elektronischen bauteils sowie konjugate davon
PCT/EP1998/005997 WO1999015539A2 (de) 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung

Country Status (10)

Country Link
US (8) US6506896B1 (de)
EP (3) EP1017703B1 (de)
JP (3) JP4674964B2 (de)
KR (3) KR100571299B1 (de)
AT (3) ATE260290T1 (de)
AU (3) AU1024699A (de)
BR (3) BR9812381A (de)
CA (3) CA2303784A1 (de)
DE (4) DE19741715A1 (de)
WO (3) WO1999015540A2 (de)

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