WO1999009960A1 - Flat systems for cutaneous and percutaneous administration involving a sticking-plaster as an information carrier, and method for producing such a plaster - Google Patents
Flat systems for cutaneous and percutaneous administration involving a sticking-plaster as an information carrier, and method for producing such a plaster Download PDFInfo
- Publication number
- WO1999009960A1 WO1999009960A1 PCT/EP1998/004846 EP9804846W WO9909960A1 WO 1999009960 A1 WO1999009960 A1 WO 1999009960A1 EP 9804846 W EP9804846 W EP 9804846W WO 9909960 A1 WO9909960 A1 WO 9909960A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- coding
- plaster
- labeling according
- information
- skin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
- G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
- G09F3/08—Fastening or securing by means not forming part of the material of the label itself
- G09F3/10—Fastening or securing by means not forming part of the material of the label itself by an adhesive layer
Definitions
- Adhesive sheet-like systems are known for the treatment of a large number of diseases and have proven themselves extremely well in many therapeutic areas of application.
- Transdermal therapeutic systems with a systemic effect are also becoming increasingly important. Their advantage is, for example, a controlled, relatively long-term release of active ingredients through the skin.
- TTS Transdermal therapeutic systems
- Such a transdermal system has an impermeable and non-adhesive backing layer to protect against undesired escape of active substances and a pressure-sensitive adhesive layer for the necessary adhesion to the skin, which can at the same time contain active substances, as well as a removable, to protect loss of active substances during storage of a TTS. usually a protective layer with a non-adhesive finish.
- a transdermal therapeutic system with a backing layer made of thermoplastic material consisting of a laminate of an outside, low-melting thermoplastic and a higher-melting thermoplastic facing the skin, consisting of a permanent, identifying coding attached to this backing layer in a locally different surface condition, surface thickness or surface roughness of this backing layer, as well as an active part containing the active ingredient.
- the invention is that this coding of the backing layer is generated by the action of pressure, heat, ultrasound or abrasion. Limits of applicability when applying the known identifying coding result from the fact that exposure to pressure or heat can be harmful to many plasters containing active ingredients.
- the capacity of a coding that can be produced by different surface properties of the back layer of a plaster is comparatively narrow.
- an additional, final work step is required to manufacture them, for example on the finished system.
- the invention is based on the object of specifying a label for both transdermal therapeutic and for non-transdermal dosage forms using a plaster as an information carrier and methods for its production which are problem-free and with a comparatively large scope provides information about properties, quantity, risks and / or side effects.
- the task is solved by labeling, in which the patch is provided with an electronically identifiable coding.
- Such coding has the advantage that it can be carried out or applied using known means, that it has a comparatively high storage capacity for information and with existing electronic reading means which any doctor, pharmacy, ambulance or medical center can have or carry with it , is decodable.
- One embodiment provides that the coding is formed on the side of the patch facing away from the skin in the form of electronically readable numbers or letters or in the form of a bar code.
- Comparatively extensive information texts can be stored on a coding field, for example the size of a standard postage stamp.
- the coding is easily deciphered with an optical, also IR reading device.
- the coding is designed in the form of a microchip on the side of the plaster facing away from the skin, such as is applied to insurance cards of health insurance companies, for example.
- This has, for example, a dimension corresponding to approximately half the area of a stamp, can be produced at low cost and can be attached to a plaster.
- the coding can also be designed on the side of the patch facing away from the skin in the form of a magnetic strip be similar to equipping a bank card with a magnetic stripe.
- the coding can be present on the adhesive-free side of an adhesive film, which is viable on the plaster before or after its application to a patient's skin.
- the marking according to the invention provides that the coding contains information about the type and amount of the active substance contained in the patch and, if applicable, all other materials.
- the coding provided for labeling the dosage forms can, however, also advantageously contain further information about, for example, side effects of the therapeutic active substance, incompatibilities with other active substances and other noteworthy special features.
- the labeling can be supplemented with great advantage, for example, in such a way that the coding contains instructions for administration of antidote in the event of recognizable occurrence of dangerous symptoms such as overdose of the active substance or acute side effects.
- a particular advantage of labeling is that personal information about the carrier of the dermal or transdermal system can be stored in coded form. Especially for high-risk patients with an extensive medical history, information about existing allergies, drug intolerance, etc. can be included in the coding as patient-specific information content.
- the basic structure of basic TTS types is described, for example, by YWChien: “Developmental Concepts and Practice in Transdermal Therapeutic Systems” in Transdermal Controlled Systemic Medications, ed. By YW Chien, Marcel Dekker, New York (1987), p.25-81.
- the coding can be contained in a drug-containing or drug-free layer of the TTS.
- a preferred embodiment contains the coding in a separate layer of a TTS located on the backing layer, consisting of backing layer and active substance-containing adhesive matrix layer.
- a further preferred embodiment contains the coding in the back layer of a TTS, consisting of back layer and active substance-containing pressure-sensitive adhesive matrix layer.
- Another preferred embodiment contains the coding in a separate layer of a TTS located between the backing layer and the active substance-containing adhesive matrix layer.
- a further preferred embodiment contains the coding in a separate, on the backing layer of a TTS, consisting of backing layer, drug-containing reservoir, the rate of release of the drug-controlling membrane and a pressure-sensitive adhesive layer.
- a further preferred embodiment contains the coding in the back layer of a TTS, consisting of back layer, reservoir containing the active substance, the speed the release of the active ingredient-controlling membrane and a pressure-sensitive adhesive layer.
- a further preferred embodiment contains the coding in a separate layer of a TTS located under the backing layer, consisting of backing layer, reservoir containing the active ingredient, the rate of release of the active ingredient-controlling membrane and an adhesive layer.
- a method for producing a marking of the type according to the preamble of claim 1 is characterized in that the coding is incorporated into or applied to the plaster when the plaster is being prepared.
- the coding can advantageously be applied to the plaster in a printing process such as screen printing or pad printing or the like.
- the coding can also be applied to the plaster using a pressure-sensitive adhesive carrier provided with the coding.
- an advantageous method for producing a marking of the plaster provides that the coding is stored in a separate layer of a multilayer plaster, or in the layer containing the active substance or in the outer covering layer.
- the labeling for both transdermal therapeutic and non-transdermal dosage forms using a plaster as an information carrier advantageously eliminates risk factors that cannot always be recognized quickly enough, for example of active ingredient combinations reacting to harmful side effects or in the case of a first pass effect as a result of a damaged TTS or an overdose, allergy reactions or the consequences of using an active ingredient after its expiry date.
- the labeling according to the invention makes it possible for the doctor in such cases to remedy serious complications with targeted auxiliary measures, in particular in cases of life-threatening conditions.
- the invention optimally achieves the object stated at the outset.
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SK232-2000A SK2322000A3 (en) | 1997-08-22 | 1998-08-04 | Flat systems for cutaneous and percutaneous administration involving a sticking-plaster as an information carrier, and method for producing such a plaster |
IL13438698A IL134386A0 (en) | 1997-08-22 | 1998-08-04 | Adhesive plaster with electronically readable code, identification based thereon and processes for the production thereof |
CA002299715A CA2299715A1 (en) | 1997-08-22 | 1998-08-04 | Flat systems for cutaneous and percutaneous administration involving a sticking-plaster as an information carrier, and method for producing such a plaster |
NZ502830A NZ502830A (en) | 1997-08-22 | 1998-08-04 | Flat systems for cutaneous and percutaneous administration involving a sticking-plaster as an information carrier relating to therapy, and method for producing such a plaster |
AU93387/98A AU737379B2 (en) | 1997-08-22 | 1998-08-04 | Identification for adhesive sheet-like dermal and trans- dermal therapeutic administration forms using an adhesive plaster as information carrier, and process for its production |
JP2000507351A JP2001513547A (en) | 1997-08-22 | 1998-08-04 | Flat system for skin and transdermal administration with adhesive plaster as information carrier and method of manufacturing the plaster |
KR1020007001802A KR20010023176A (en) | 1997-08-22 | 1998-08-04 | Flat systems for cutaneous and percutaneous administration involving a sticking-plaster as an information carrier, and method for producing such a plaster |
HU0004184A HUP0004184A3 (en) | 1997-08-22 | 1998-08-04 | Flat systems for cutaneous and percutaneous administration involving a sticking-plaster as an information carrier, and method for producing such a plaster |
EP98946274A EP1007016A1 (en) | 1997-08-22 | 1998-08-04 | Flat systems for cutaneous and percutaneous administration involving a sticking-plaster as an information carrier, and method for producing such a plaster |
NO20000814A NO20000814L (en) | 1997-08-22 | 2000-02-18 | Identification of adhesive surface-shaped dermal and transdermal therapeutic dosage forms using an adhesive patch as an information carrier, as well as methods of their preparation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19736520A DE19736520A1 (en) | 1997-08-22 | 1997-08-22 | New adhesive plaster containing electronic information |
DE19736520.5 | 1997-08-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999009960A1 true WO1999009960A1 (en) | 1999-03-04 |
Family
ID=7839806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1998/004846 WO1999009960A1 (en) | 1997-08-22 | 1998-08-04 | Flat systems for cutaneous and percutaneous administration involving a sticking-plaster as an information carrier, and method for producing such a plaster |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1007016A1 (en) |
JP (1) | JP2001513547A (en) |
KR (1) | KR20010023176A (en) |
AU (1) | AU737379B2 (en) |
CA (1) | CA2299715A1 (en) |
DE (1) | DE19736520A1 (en) |
HU (1) | HUP0004184A3 (en) |
ID (1) | ID24885A (en) |
IL (1) | IL134386A0 (en) |
NO (1) | NO20000814L (en) |
NZ (1) | NZ502830A (en) |
PL (1) | PL338736A1 (en) |
SK (1) | SK2322000A3 (en) |
TR (1) | TR200000408T2 (en) |
WO (1) | WO1999009960A1 (en) |
ZA (1) | ZA987580B (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001039748A2 (en) * | 1999-12-03 | 2001-06-07 | Psimedia Limited | Orally administrable pharmaceutical product and method of fabrication therefor |
WO2001041736A2 (en) * | 1999-12-10 | 2001-06-14 | Massachusetts Institute Of Technology | Microchip devices for delivery of molecules and methods of fabrication thereof |
US6730072B2 (en) | 2000-05-30 | 2004-05-04 | Massachusetts Institute Of Technology | Methods and devices for sealing microchip reservoir devices |
EP1688132A2 (en) * | 1999-12-10 | 2006-08-09 | Massachussetts Institute of Technology | Microchip devices for delivery of molecules and methods of fabrication thereof |
US7985386B2 (en) | 2000-03-02 | 2011-07-26 | Microchips, Inc. | Implantable medical device for diagnostic sensing |
WO2017167728A1 (en) * | 2016-03-31 | 2017-10-05 | Amw Gmbh | Transdermal application system with information layer |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10141836A1 (en) * | 2001-08-27 | 2003-03-27 | Hartmann Paul Ag | Medical kit for use in the supply of probe or catheter exit sites |
WO2000004480A1 (en) | 1998-07-20 | 2000-01-27 | Noven Pharmaceuticals, Inc. | A method of individually tracking and identifying a drug delivery device |
DE19950295A1 (en) * | 1999-10-19 | 2001-04-26 | Beiersdorf Ag | Foil-based dressing material with imprint |
DE10015930A1 (en) * | 2000-03-30 | 2001-10-18 | Dieter Hafner | Carrier for chemical, pharmaceutical or cosmetic substances is provided with at least one section with encoded information which is readable by a code reading device |
DE102006011340A1 (en) * | 2006-03-09 | 2007-09-20 | Grünenthal GmbH | Active substance-containing patches with improved handling |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0114125A2 (en) * | 1983-01-20 | 1984-07-25 | Almedco, Inc. | Medication application systems |
JPH08712A (en) * | 1994-06-27 | 1996-01-09 | Olympus Optical Co Ltd | Medicament with two dimensional data code |
DE19519593C1 (en) * | 1995-05-29 | 1996-08-29 | Horstmann Michael | Transdermal therapeutic system with thermoplastic back layer |
US5700998A (en) * | 1995-10-31 | 1997-12-23 | Palti; Yoram | Drug coding and delivery system |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6541786A (en) * | 1985-10-09 | 1987-05-05 | Desitin Arzneimittel Gmbh | Process for producing an administration or dosage form of drugs, reagents or other active ingredients |
DE3630603A1 (en) * | 1986-09-09 | 1988-03-10 | Desitin Arzneimittel Gmbh | PHARMACEUTICAL AND DOSAGE FORM FOR MEDICINAL ACTIVE SUBSTANCES, REAGENTS OR THE LIKE, AND METHOD FOR THE PRODUCTION THEREOF |
DE4223004A1 (en) * | 1992-07-13 | 1994-01-20 | Liedtke Pharmed Gmbh | Single-dose semi-solid topical dosage form for transdermal therapy |
DE9409784U1 (en) * | 1994-06-10 | 1994-08-11 | Effner Biomet Gmbh | Device for the transdermal application of active substances |
DE19524083C2 (en) * | 1995-07-01 | 2000-07-06 | Lohmann Therapie Syst Lts | Process for the disposal of transdermal application hazardous waste |
DE19708674C2 (en) * | 1996-03-25 | 2002-02-07 | Lohmann Therapie Syst Lts | Transdermal therapeutic system with a drug-containing film layer and a soluble release layer, and a method for its preparation |
US5797898A (en) * | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
-
1997
- 1997-08-22 DE DE19736520A patent/DE19736520A1/en not_active Withdrawn
-
1998
- 1998-08-04 EP EP98946274A patent/EP1007016A1/en not_active Withdrawn
- 1998-08-04 SK SK232-2000A patent/SK2322000A3/en unknown
- 1998-08-04 JP JP2000507351A patent/JP2001513547A/en active Pending
- 1998-08-04 AU AU93387/98A patent/AU737379B2/en not_active Ceased
- 1998-08-04 HU HU0004184A patent/HUP0004184A3/en unknown
- 1998-08-04 KR KR1020007001802A patent/KR20010023176A/en not_active Application Discontinuation
- 1998-08-04 NZ NZ502830A patent/NZ502830A/en unknown
- 1998-08-04 CA CA002299715A patent/CA2299715A1/en not_active Abandoned
- 1998-08-04 ID IDW20000282A patent/ID24885A/en unknown
- 1998-08-04 TR TR2000/00408T patent/TR200000408T2/en unknown
- 1998-08-04 IL IL13438698A patent/IL134386A0/en unknown
- 1998-08-04 PL PL98338736A patent/PL338736A1/en unknown
- 1998-08-04 WO PCT/EP1998/004846 patent/WO1999009960A1/en not_active Application Discontinuation
- 1998-08-21 ZA ZA987580A patent/ZA987580B/en unknown
-
2000
- 2000-02-18 NO NO20000814A patent/NO20000814L/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0114125A2 (en) * | 1983-01-20 | 1984-07-25 | Almedco, Inc. | Medication application systems |
JPH08712A (en) * | 1994-06-27 | 1996-01-09 | Olympus Optical Co Ltd | Medicament with two dimensional data code |
DE19519593C1 (en) * | 1995-05-29 | 1996-08-29 | Horstmann Michael | Transdermal therapeutic system with thermoplastic back layer |
US5700998A (en) * | 1995-10-31 | 1997-12-23 | Palti; Yoram | Drug coding and delivery system |
Non-Patent Citations (1)
Title |
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PATENT ABSTRACTS OF JAPAN vol. 096, no. 005 31 May 1996 (1996-05-31) * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001039748A2 (en) * | 1999-12-03 | 2001-06-07 | Psimedia Limited | Orally administrable pharmaceutical product and method of fabrication therefor |
WO2001039748A3 (en) * | 1999-12-03 | 2002-01-03 | Qinetiq Ltd | Orally administrable pharmaceutical product and method of fabrication therefor |
AU769952B2 (en) * | 1999-12-03 | 2004-02-12 | Psimedica Limited | Orally administrable pharmaceutical product and method of fabrication therefor |
WO2001041736A2 (en) * | 1999-12-10 | 2001-06-14 | Massachusetts Institute Of Technology | Microchip devices for delivery of molecules and methods of fabrication thereof |
WO2001041736A3 (en) * | 1999-12-10 | 2002-01-31 | Massachusetts Inst Technology | Microchip devices for delivery of molecules and methods of fabrication thereof |
US6808522B2 (en) | 1999-12-10 | 2004-10-26 | Massachusetts Institute Of Technology | Microchip devices for delivery of molecules and methods of fabrication thereof |
EP1688132A2 (en) * | 1999-12-10 | 2006-08-09 | Massachussetts Institute of Technology | Microchip devices for delivery of molecules and methods of fabrication thereof |
EP1688132A3 (en) * | 1999-12-10 | 2009-10-07 | Massachussetts Institute of Technology | Microchip devices for delivery of molecules and methods of fabrication thereof |
US7985386B2 (en) | 2000-03-02 | 2011-07-26 | Microchips, Inc. | Implantable medical device for diagnostic sensing |
US6730072B2 (en) | 2000-05-30 | 2004-05-04 | Massachusetts Institute Of Technology | Methods and devices for sealing microchip reservoir devices |
WO2017167728A1 (en) * | 2016-03-31 | 2017-10-05 | Amw Gmbh | Transdermal application system with information layer |
Also Published As
Publication number | Publication date |
---|---|
IL134386A0 (en) | 2001-04-30 |
AU9338798A (en) | 1999-03-16 |
AU737379B2 (en) | 2001-08-16 |
SK2322000A3 (en) | 2000-07-11 |
JP2001513547A (en) | 2001-09-04 |
NO20000814D0 (en) | 2000-02-18 |
NO20000814L (en) | 2000-02-18 |
CA2299715A1 (en) | 1999-03-04 |
TR200000408T2 (en) | 2000-09-21 |
PL338736A1 (en) | 2000-11-20 |
HUP0004184A2 (en) | 2001-04-28 |
NZ502830A (en) | 2001-08-31 |
ZA987580B (en) | 1999-02-23 |
HUP0004184A3 (en) | 2001-08-28 |
ID24885A (en) | 2000-08-31 |
EP1007016A1 (en) | 2000-06-14 |
DE19736520A1 (en) | 1999-02-25 |
KR20010023176A (en) | 2001-03-26 |
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