WO1999008716A3 - Process for preparation of lyophilised contrast agents - Google Patents

Process for preparation of lyophilised contrast agents Download PDF

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Publication number
WO1999008716A3
WO1999008716A3 PCT/GB1998/002491 GB9802491W WO9908716A3 WO 1999008716 A3 WO1999008716 A3 WO 1999008716A3 GB 9802491 W GB9802491 W GB 9802491W WO 9908716 A3 WO9908716 A3 WO 9908716A3
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
preparation
containers
gas
contrast agents
Prior art date
Application number
PCT/GB1998/002491
Other languages
French (fr)
Other versions
WO1999008716A2 (en
Inventor
Tore Omtveit
Original Assignee
Nycomed Imaging As
Tore Omtveit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As, Tore Omtveit filed Critical Nycomed Imaging As
Priority to AU88161/98A priority Critical patent/AU8816198A/en
Priority to EP98939754A priority patent/EP1007103A2/en
Priority to JP2000509452A priority patent/JP2001515055A/en
Publication of WO1999008716A2 publication Critical patent/WO1999008716A2/en
Publication of WO1999008716A3 publication Critical patent/WO1999008716A3/en
Priority to NO20000622A priority patent/NO20000622L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Abstract

The invention provides a process for the preparation of a fluorocarbon-containing lyophilised contrast agent which comprises lyophilising lyophilisable precursor material contained in one or more containers in a lyophilisation or like vacuum chamber, introducing said fluorinated gas into said chamber and effecting sealing closure of said container or containers, characterised in that, following closure of said container or containers, an overpressure of an atmoshperic gas is applied to said chamber and said fluorocarbon gas is allowed to condense in a condensation vessel connected to said chamber.
PCT/GB1998/002491 1997-08-19 1998-08-19 Process for preparation of lyophilised contrast agents WO1999008716A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU88161/98A AU8816198A (en) 1997-08-19 1998-08-19 Improvements in or relating to contrast agents
EP98939754A EP1007103A2 (en) 1997-08-19 1998-08-19 Process for preparation of lyophilised contrast agents
JP2000509452A JP2001515055A (en) 1997-08-19 1998-08-19 Improvements in contrast agents
NO20000622A NO20000622L (en) 1997-08-19 2000-02-08 Fluorocarbon gas recovery

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9717589.7A GB9717589D0 (en) 1997-08-19 1997-08-19 Improvements in or relating to contrast agents
GB9717589.7 1997-08-19
US6431497P 1997-11-05 1997-11-05

Publications (2)

Publication Number Publication Date
WO1999008716A2 WO1999008716A2 (en) 1999-02-25
WO1999008716A3 true WO1999008716A3 (en) 1999-08-12

Family

ID=10817734

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/002491 WO1999008716A2 (en) 1997-08-19 1998-08-19 Process for preparation of lyophilised contrast agents

Country Status (7)

Country Link
EP (1) EP1007103A2 (en)
JP (1) JP2001515055A (en)
AU (1) AU8816198A (en)
GB (1) GB9717589D0 (en)
NO (1) NO20000622L (en)
WO (1) WO1999008716A2 (en)
ZA (1) ZA987483B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2243350T3 (en) * 2001-01-31 2005-12-01 Bracco International B.V. LIOFIZABLE CONTRAST AGENT UNDERSTANDING GAS MICROBUBBLES.
MXPA05007730A (en) * 2003-02-04 2006-01-31 Bracco Int Bv Ultrasound contrast agents and process for the preparation thereof.
CA2547024C (en) 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
AU2005273865B2 (en) 2004-08-18 2011-02-24 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
EP2477550A4 (en) * 2009-09-15 2013-12-04 Univ Columbia Systems, methods, and devices for microbubbles
CN104349827A (en) * 2012-04-30 2015-02-11 通用电气医疗集团股份有限公司 Method for filling container with foamable composition
GB201405735D0 (en) * 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
GB201411423D0 (en) 2014-06-26 2014-08-13 Ge Healthcare As Lipid sterilisation method
WO2023111332A1 (en) * 2021-12-16 2023-06-22 Bracco Suisse Sa Method for extracting a fluorinated gas

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028797A1 (en) * 1993-06-11 1994-12-22 Unger Evan C Methods of preparing gas-filled liposomes
WO1994028874A1 (en) * 1993-06-11 1994-12-22 Unger Evan C Novel therapeutic delivery systems
WO1996008234A1 (en) * 1994-09-16 1996-03-21 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
WO1996018420A1 (en) * 1994-12-16 1996-06-20 Bracco Research S.A. Method of storage of ultrasonic gas suspensions
WO1997029783A1 (en) * 1996-02-19 1997-08-21 Nycomed Imaging A/S Improvements in or relating to contrast agents
WO1997040858A1 (en) * 1996-04-30 1997-11-06 Imarx Pharmaceutical Corp. Novel dispersible lipid blends and uses therefor
WO1998005364A2 (en) * 1996-08-02 1998-02-12 Marsden, John, Christopher Improvements in or relating to contrast agents
WO1998010798A1 (en) * 1996-09-11 1998-03-19 Imarx Pharmaceutical Corp. Improved methods for diagnostic imaging using a contrast agent and a vasodilator

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028797A1 (en) * 1993-06-11 1994-12-22 Unger Evan C Methods of preparing gas-filled liposomes
WO1994028874A1 (en) * 1993-06-11 1994-12-22 Unger Evan C Novel therapeutic delivery systems
WO1996008234A1 (en) * 1994-09-16 1996-03-21 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
WO1996018420A1 (en) * 1994-12-16 1996-06-20 Bracco Research S.A. Method of storage of ultrasonic gas suspensions
WO1997029783A1 (en) * 1996-02-19 1997-08-21 Nycomed Imaging A/S Improvements in or relating to contrast agents
WO1997040858A1 (en) * 1996-04-30 1997-11-06 Imarx Pharmaceutical Corp. Novel dispersible lipid blends and uses therefor
WO1998005364A2 (en) * 1996-08-02 1998-02-12 Marsden, John, Christopher Improvements in or relating to contrast agents
WO1998010798A1 (en) * 1996-09-11 1998-03-19 Imarx Pharmaceutical Corp. Improved methods for diagnostic imaging using a contrast agent and a vasodilator

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
NINTH INTERNATIONAL CONGRESS ON ECHOCARDIOGRAPHY: CLINICAL CARDIOLOGY, 5 February 1998 (1998-02-05) - 8 February 1998 (1998-02-08), Rome, Italy *
SCHNEIDER M ET AL: "BR1: A NEW ULTRASONOGRAPHIC CONTRAST AGENT BASED ON SULFUR HEXAFLUORIDE-FILLED MICROBUBBLES", INVESTIGATIVE RADIOLOGY, vol. 30, no. 8, August 1995 (1995-08-01), pages 451 - 457, XP002018870 *
SHARMA S. K. ET AL: "Emulsification methods for perfluorochemicals", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 14, 1988, pages 2371 - 2376, XP002087506 *
UNGER E. C. ET AL: "In vitro studies of a new thrombus-specific ultrasound contrast agent", AMERICAN JOURNAL OF CARDIOLOGY, vol. 81, no. 12a, 18 July 1998 (1998-07-18), pages 58g - 61g, XP002087505 *

Also Published As

Publication number Publication date
NO20000622D0 (en) 2000-02-08
WO1999008716A2 (en) 1999-02-25
NO20000622L (en) 2000-03-10
AU8816198A (en) 1999-03-08
ZA987483B (en) 1999-05-21
EP1007103A2 (en) 2000-06-14
JP2001515055A (en) 2001-09-18
GB9717589D0 (en) 1997-10-22

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