WO1999008691A3 - Use of locally delivered metal ions for treatment of periodontal disease - Google Patents

Use of locally delivered metal ions for treatment of periodontal disease Download PDF

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Publication number
WO1999008691A3
WO1999008691A3 PCT/US1998/016738 US9816738W WO9908691A3 WO 1999008691 A3 WO1999008691 A3 WO 1999008691A3 US 9816738 W US9816738 W US 9816738W WO 9908691 A3 WO9908691 A3 WO 9908691A3
Authority
WO
WIPO (PCT)
Prior art keywords
metal ions
periodontal disease
periodontal
treatment
disease
Prior art date
Application number
PCT/US1998/016738
Other languages
French (fr)
Other versions
WO1999008691A8 (en
WO1999008691A2 (en
Inventor
F Donald Roberts
Phillip M Friden
Peter Spacciapoli
Eric Nelson
Original Assignee
Periodintix Inc
F Donald Roberts
Phillip M Friden
Peter Spacciapoli
Eric Nelson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Periodintix Inc, F Donald Roberts, Phillip M Friden, Peter Spacciapoli, Eric Nelson filed Critical Periodintix Inc
Priority to CA002301065A priority Critical patent/CA2301065A1/en
Priority to IL13422598A priority patent/IL134225A0/en
Priority to EP98942041A priority patent/EP1011693A1/en
Priority to JP2000509430A priority patent/JP2001515042A/en
Priority to KR1020007001427A priority patent/KR20010022825A/en
Priority to AU90178/98A priority patent/AU9017898A/en
Publication of WO1999008691A2 publication Critical patent/WO1999008691A2/en
Publication of WO1999008691A3 publication Critical patent/WO1999008691A3/en
Priority to NO20000688A priority patent/NO20000688L/en
Publication of WO1999008691A8 publication Critical patent/WO1999008691A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

Periodontal disease can be treated by the administration of metal ions, preferably silver ions, to the site where the microorganisms that cause this disease reside. Administration can be to periodontal pockets or adjacent to exposed tooth roots or alveolar bone during periodontal surgical procedures. The metal ions can be administered in polymeric microparticles, deformable films or microparticles embedded within deformable films. The metal ions are particularly microbiocidal to the bacterial pathogens that are the causative agents of periodontal disease.
PCT/US1998/016738 1997-08-14 1998-08-13 Use of locally delivered metal ions for treatment of periodontal disease WO1999008691A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002301065A CA2301065A1 (en) 1997-08-14 1998-08-13 Use of locally delivered metal ions for treatment of periodontal disease
IL13422598A IL134225A0 (en) 1997-08-14 1998-08-13 Use of locally delivered metal ions for treatment of periodontal disease
EP98942041A EP1011693A1 (en) 1997-08-14 1998-08-13 Use of locally delivered metal ions for treatment of periodontal disease
JP2000509430A JP2001515042A (en) 1997-08-14 1998-08-13 Use of locally delivered metal ions for the treatment of periodontal disease
KR1020007001427A KR20010022825A (en) 1997-08-14 1998-08-13 Use of locally delivered metal ions for treatment of periodontal disease
AU90178/98A AU9017898A (en) 1997-08-14 1998-08-13 Use of locally delivered metal ions for treatment of periodontal disease
NO20000688A NO20000688L (en) 1997-08-14 2000-02-11 Use of locally delivered metal ions for the treatment of periodontal disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/911,413 1997-08-14
US08/911,413 US6153210A (en) 1997-08-14 1997-08-14 Use of locally delivered metal ions for treatment of periodontal disease

Publications (3)

Publication Number Publication Date
WO1999008691A2 WO1999008691A2 (en) 1999-02-25
WO1999008691A3 true WO1999008691A3 (en) 1999-05-06
WO1999008691A8 WO1999008691A8 (en) 2000-04-20

Family

ID=25430198

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/016738 WO1999008691A2 (en) 1997-08-14 1998-08-13 Use of locally delivered metal ions for treatment of periodontal disease

Country Status (9)

Country Link
US (1) US6153210A (en)
EP (1) EP1011693A1 (en)
JP (1) JP2001515042A (en)
KR (1) KR20010022825A (en)
AU (1) AU9017898A (en)
CA (1) CA2301065A1 (en)
IL (1) IL134225A0 (en)
NO (1) NO20000688L (en)
WO (1) WO1999008691A2 (en)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE29908415U1 (en) * 1999-05-18 1999-07-22 Carl Agents for the treatment of local periodontal infections
EP1066825A1 (en) * 1999-06-17 2001-01-10 The Procter & Gamble Company An anti-microbial body care product
IL133473A0 (en) * 1999-12-12 2001-04-30 Avenir R & B Medical Technolog Bactericidal haemostatic preparations for local use and the methods of their production and conservation
US6551608B2 (en) * 2000-03-06 2003-04-22 Porex Technologies Corporation Porous plastic media with antiviral or antimicrobial properties and processes for making the same
US20020022048A1 (en) * 2000-05-26 2002-02-21 Bromberg Lev E. Composite wafer for controlled drug delivery
US20040191329A1 (en) * 2000-07-27 2004-09-30 Burrell Robert E. Compositions and methods of metal-containing materials
US20030180379A1 (en) * 2000-07-27 2003-09-25 Burrell Robert E. Solutions and aerosols of metal-containing compounds
US6726898B2 (en) 2000-11-17 2004-04-27 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6576226B1 (en) * 2000-11-17 2003-06-10 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
DE20020649U1 (en) * 2000-12-06 2002-04-11 Stryker Trauma Gmbh Device for surgical or therapeutic use, in particular implants and surgical instruments and their accessories
US7090497B1 (en) 2001-02-21 2006-08-15 Harris David M Method of periodontal laser treatment
JP2004529929A (en) * 2001-04-23 2004-09-30 ニュクリスト ファーマシューティカルズ コーポレーション Use of metals for induction of apoptosis and inhibition of matrix metalloproteinases
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US8663687B2 (en) * 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US7666337B2 (en) 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US7425292B2 (en) 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US7910641B2 (en) 2001-10-12 2011-03-22 Monosol Rx, Llc PH modulated films for delivery of actives
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
ATE536868T1 (en) * 2001-10-12 2011-12-15 Monosolrx Llc UNIFORM FILMS AS FAST DISSOLVING ADMINISTRATION FORMS CONTAINING FLAVOR-MASKING SUBSTANCE
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US20040127892A1 (en) * 2002-01-31 2004-07-01 Harris David M. Periodontal laser and methods
US8017150B2 (en) 2002-04-11 2011-09-13 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
KR20030084135A (en) * 2002-04-25 2003-11-01 김형순 Inhibition Tools for Streptococcus mutans
US8986737B2 (en) * 2002-09-05 2015-03-24 Wm. Marsh Rice University Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth
NZ539166A (en) * 2002-09-05 2008-03-28 Univ Wm Marsh Rice A controlled release device comprising antibiotic microspheres for treatment of infections and osteomyelitis
CN102670568A (en) * 2003-05-28 2012-09-19 莫诺索尔克斯有限公司 Polyethylene oxide-based films and drug delivery systems made therefrom
CA2542221A1 (en) * 2003-10-23 2005-05-06 Pfizer Products Inc. Vaccine for periodontal disease
DE60314638T2 (en) * 2003-11-14 2008-03-06 The Procter & Gamble Company, Cincinnati Polymeric compositions for sustained release of volatile materials
DE10358748A1 (en) 2003-12-12 2005-07-14 Lts Lohmann Therapie-Systeme Ag Dosage form based on crosslinked hydrophilic polymers
US7335613B2 (en) * 2004-04-08 2008-02-26 Rohm And Haas Company Fiber substrate with antibacterial finish and methods of making and using the same
US7390774B2 (en) * 2004-04-08 2008-06-24 Rohm And Haas Company Antibacterial composition and methods of making and using the same
EP1604690B1 (en) * 2004-06-08 2014-03-05 The Procter & Gamble Company Polymeric hot melt adhesive compositions for sustained release of volatile materials
EP1624013A1 (en) * 2004-08-05 2006-02-08 The Procter & Gamble Company Compositions for sustained release of volatile materials
EP1655344A1 (en) * 2004-11-05 2006-05-10 The Procter & Gamble Company Polymeric compositions for sustained release of volatile materials
EP1721621A1 (en) * 2005-05-09 2006-11-15 The Procter & Gamble Company Perfume releasing packages
US9149558B2 (en) 2005-05-19 2015-10-06 Ethicon, Inc. Antimicrobial polymer compositions and the use thereof
US9180229B2 (en) * 2005-05-19 2015-11-10 Ethicon, Inc. Antimicrobial polymer compositions and the use thereof
DE602006000082T2 (en) * 2005-07-07 2008-05-15 Rohm And Haas Co. Fiber with antimicrobial composition
AU2006222708A1 (en) * 2005-10-07 2007-04-26 Rohm And Haas Company Method for disinfecting or sanitizing a surface
ES2622738T3 (en) 2005-12-07 2017-07-07 The Procter & Gamble Company Polymeric compositions for sustained release of volatile materials
EP1816165A1 (en) * 2006-02-03 2007-08-08 The Procter and Gamble Company Tackified polymeric compositions for perfume delivery
JP4739452B2 (en) 2006-09-20 2011-08-03 モノソル アールエックス リミテッド ライアビリティ カンパニー Eatable water-soluble film containing flavor enhancer to reduce foaming
US20100266990A1 (en) * 2006-12-22 2010-10-21 Marianna Cooley Dental antimicrobial formulations and methods of using the same
WO2009085651A1 (en) 2007-12-20 2009-07-09 Nucryst Pharmaceuticals Corp. Metal carbonate particles for use in medicine and methods of making thereof
US8905760B2 (en) * 2008-11-04 2014-12-09 Duane C. Keller Methods and systems for progressively treating and controlling oral periopathogens causing systemic inflammations
US8956161B2 (en) 2008-11-04 2015-02-17 Duane C Keller Article and method for controlling oral-originated systemic disease
US9192626B2 (en) * 2009-06-10 2015-11-24 American Silver, Llc Dental uses of silver hydrosol
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
CA2807271C (en) 2010-06-10 2018-07-31 Midatech Limited Nanoparticle film delivery systems
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
CA2817229A1 (en) 2010-11-08 2012-05-18 Naihong Li Gels and hydrogels
US8591229B2 (en) 2010-12-16 2013-11-26 Duane C. Keller Devices and methods for creating a positive pressure environment for treatment of oral biofilms associated with periodontal disease
US11147751B2 (en) 2010-12-23 2021-10-19 Colgate-Palmolive Company Fluid compositions comprising a structuring agent
RU2559589C2 (en) 2010-12-23 2015-08-10 Колгейт-Палмолив Компани Aqueous oral care composition containing xanthan gum, cellulose gum and carbomer
CN107648070A (en) 2011-12-15 2018-02-02 高露洁-棕榄公司 Aqueous oral care composition
US8956157B2 (en) * 2012-01-31 2015-02-17 Alexander Philippovich Rutberg Apparatus and method for treatment of periodontal disease
US11007143B2 (en) 2013-03-15 2021-05-18 Cda Research Group, Inc. Topical copper ion treatments and methods of treatment using topical copper ion treatments in the oral-respiratory-otic areas of the body
US11000545B2 (en) 2013-03-15 2021-05-11 Cda Research Group, Inc. Copper ion compositions and methods of treatment for conditions caused by coronavirus and influenza
US11318089B2 (en) 2013-03-15 2022-05-03 Cda Research Group, Inc. Topical copper ion treatments and methods of making topical copper ion treatments for use in various anatomical areas of the body
US10398733B2 (en) 2013-03-15 2019-09-03 Cda Research Group, Inc. Topical copper ion treatments and methods of treatment using topical copper ion treatments in the dermatological areas of the body
US11083750B2 (en) 2013-03-15 2021-08-10 Cda Research Group, Inc. Methods of treatment using topical copper ion formulations
JP6241610B2 (en) * 2014-02-21 2017-12-06 学校法人大阪歯科大学 Oral composition and method for treating periodontal disease in animals
TWI566783B (en) * 2015-08-21 2017-01-21 王式禹 Mouthwash comprising silver polyacrylate
WO2017192921A1 (en) 2016-05-05 2017-11-09 Monosol Rx, Llc Enhanced delivery epinephrine compositions
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
RU2693678C1 (en) * 2018-03-19 2019-07-03 Федеральное государственное бюджетное образовательное учреждение высшего образования "Ставропольский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СтГМУ Минздрава России) Method of treating chronic generalized periodontitis
US11193184B2 (en) 2019-02-22 2021-12-07 Cda Research Group, Inc. System for use in producing a metal ion suspension and process of using same
ES2791771B2 (en) * 2019-05-03 2021-05-11 Nanomateriales Y Polimeros S L Hydrophilic nonwoven nanofiber membrane to promote bone regeneration
KR102260902B1 (en) * 2019-11-28 2021-06-03 긴미라이 가부시키가이샤 Silver Sterilizing Sponge Teeth Cleaning Appliance, Silver Sterilizing Toothbrush And Making Method For The Same

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3337405A (en) * 1961-01-18 1967-08-22 Rech S Scient Soc D Product for dental use including a silver complex and methods for such use
DE2811522B1 (en) * 1978-03-16 1979-04-05 Fresenius Chem Pharm Ind Dentifrices
EP0241179A1 (en) * 1986-03-25 1987-10-14 Rohto Pharmaceutical Co., Ltd. Pharmaceutical composition for periodontal diseases
JPH02184615A (en) * 1989-01-10 1990-07-19 Obujie Kagaku Kenkyusho:Kk Dentifrice composition
EP0508524A1 (en) * 1991-04-12 1992-10-14 Unilever N.V. Use of zinc ions for the treatment of periodontitis
US5260066A (en) * 1992-01-16 1993-11-09 Srchem Incorporated Cryogel bandage containing therapeutic agent
JPH06154030A (en) * 1993-07-06 1994-06-03 Dentaru Kagaku Kk Antimicrobial apatite and antimicrobial resin containing the same
US5387419A (en) * 1988-03-31 1995-02-07 The University Of Michigan System for controlled release of antiarrhythmic agents
WO1995029664A1 (en) * 1994-05-03 1995-11-09 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
WO1996009808A1 (en) * 1994-09-26 1996-04-04 The Procter & Gamble Company Aqueous oral compositions
WO1997016212A1 (en) * 1995-11-01 1997-05-09 Bristol-Myers Squibb Company Water soluble films
RU2078559C1 (en) * 1993-07-05 1997-05-10 Семен Евстафьевич Манойлов Method of parodontosis treatment
CZ282292B6 (en) * 1995-02-24 1997-06-11 Odbor Správy Majetku Mo Pharmaceutical preparation exhibiting antimicrobial activity

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US33093A (en) * 1861-08-20 Improvement in potato-diggers
US3739773A (en) * 1963-10-31 1973-06-19 American Cyanamid Co Polyglycolic acid prosthetic devices
US3875937A (en) * 1963-10-31 1975-04-08 American Cyanamid Co Surgical dressings of absorbable polymers
US3419006A (en) * 1966-08-08 1968-12-31 Union Carbide Corp Novel dressing and use thereof
US3639575A (en) * 1968-06-19 1972-02-01 Basf Wyandotte Corp Silver ion gel compositions and method of using the same
WO1981002667A1 (en) * 1980-03-27 1981-10-01 Nat Res Dev Antimicrobial surgical implants
US4376764A (en) * 1981-08-10 1983-03-15 Basf Wyandotte Corporation Silver ion gel compositions
US4570629A (en) * 1982-03-17 1986-02-18 University Of Illinois Foundation Hydrophilic biopolymeric copolyelectrolytes, and biodegradable wound dressing comprising same
US4588400A (en) * 1982-12-16 1986-05-13 Johnson & Johnson Products, Inc. Liquid loaded pad for medical applications
US4559223A (en) * 1983-05-20 1985-12-17 Daltex Medical Sciences, Inc. Silver sulfadiazine and/or zinc sulfadiazine-containing toothpaste or oral medicament
JPS59222406A (en) * 1983-06-01 1984-12-14 Teijin Ltd Pharmaceutical preparation for remedying periodontosis and its preparation
US4685883A (en) * 1983-09-12 1987-08-11 Jernberg Gary R Local delivery of chemotherapeutic agents for the treatment of periodontal disease
US4892736A (en) * 1983-10-07 1990-01-09 The Forsyth Dental Infirmary For Children Intra-pocket drug delivery devices for treatment of periodontal diseases
US4764377A (en) * 1983-10-07 1988-08-16 The Forsyth Dental Infirmary For Children Intra-pocket drug delivery devices for treatment of periodontal diseases
US5571521A (en) * 1984-01-16 1996-11-05 Lasker; Sigmund E. Composition containing silver ammonium phenytoin complex and a phenytoin and use of said composition
US4847049A (en) * 1985-12-18 1989-07-11 Vitaphore Corporation Method of forming chelated collagen having bactericidal properties
JPS62223115A (en) * 1986-03-25 1987-10-01 Rooto Seiyaku Kk Remedy for periodontosis
JPS62223112A (en) * 1986-03-25 1987-10-01 Rooto Seiyaku Kk Remedy for periodontosis
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
US4919939A (en) * 1986-04-29 1990-04-24 Pharmetrix Corporation Periodontal disease treatment system
IL78826A (en) * 1986-05-19 1991-05-12 Yissum Res Dev Co Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
USRE33093E (en) 1986-06-16 1989-10-17 Johnson & Johnson Consumer Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
US4713243A (en) * 1986-06-16 1987-12-15 Johnson & Johnson Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
US4728323A (en) * 1986-07-24 1988-03-01 Minnesota Mining And Manufacturing Company Antimicrobial wound dressings
DE3751254D1 (en) * 1986-10-31 1995-05-24 Nippon Zeon Co Wound dressing.
US4846165A (en) * 1986-11-26 1989-07-11 Dentsply Research & Development Corp. Wound dressing membrane
US4808402A (en) * 1987-05-29 1989-02-28 Northwestern University Method and compositions for modulating neovascularization
US4978391A (en) * 1987-11-13 1990-12-18 Dentsply Management Corp. Intraoral medicament delivery and procedure
US5019096A (en) * 1988-02-11 1991-05-28 Trustees Of Columbia University In The City Of New York Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
DE3831657A1 (en) * 1988-09-17 1990-03-22 Boehringer Ingelheim Kg DEVICE FOR THE OSTEOSYNTHESIS AND METHOD FOR THE PRODUCTION THEREOF
US5009898A (en) * 1988-09-29 1991-04-23 Kabushiki Kaisha Sangi Antimicrobial hydroxyapatite powders and methods for preparing them
US5236355A (en) * 1988-12-22 1993-08-17 American Cyanamid Company Apparatus for the treatment of periodontal disease
DE68915132T2 (en) * 1988-12-22 1994-12-08 American Cyanamid Co Process for the treatment of periodontitis by protracted drug delivery of medicinal products in the tooth cavity, composition thereof and device for administration.
JP2719671B2 (en) * 1989-07-11 1998-02-25 日本ゼオン株式会社 Wound dressing
US5077049A (en) * 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
US5059123A (en) * 1990-05-14 1991-10-22 Jernberg Gary R Periodontal barrier and method for aiding periodontal tissue regeneration
US5197882A (en) * 1990-05-14 1993-03-30 Gary R. Jernberg Periodontal barrier and method for aiding periodontal tissue regeneration agents
US5102666A (en) * 1990-09-11 1992-04-07 Oramed, Inc. Calcium polycarbophil controlled release composition and method
AU8935591A (en) * 1990-10-30 1992-05-26 Alza Corporation Drug delivery system and method
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
AU656384B2 (en) * 1991-04-10 1995-02-02 Christopher C. Capelli Antimicrobial compositions useful for medical applications
US5340581A (en) * 1991-08-23 1994-08-23 Gillette Canada, Inc. Sustained-release matrices for dental application
US5468489A (en) * 1991-10-29 1995-11-21 Sangi Co., Ltd. Dentifrice containing antibacterial material
US5298237A (en) * 1992-01-24 1994-03-29 The Trustees Of Columbia University In The City Of New York Gel composition for reduction of gingival inflammation and retardation of dental plaque
US5688492A (en) * 1992-05-22 1997-11-18 The Boots Company Plc, Oral hygiene composition
GB9210947D0 (en) * 1992-05-22 1992-07-08 Boots Co Plc Oral hygiene composition
US5534288A (en) * 1993-03-23 1996-07-09 United States Surgical Corporation Infection-resistant surgical devices and methods of making them
US5707962A (en) * 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
US5955097A (en) * 1996-10-18 1999-09-21 Virotex Corporation Pharmaceutical preparation applicable to mucosal surfaces and body tissues

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3337405A (en) * 1961-01-18 1967-08-22 Rech S Scient Soc D Product for dental use including a silver complex and methods for such use
DE2811522B1 (en) * 1978-03-16 1979-04-05 Fresenius Chem Pharm Ind Dentifrices
FR2419726A1 (en) * 1978-03-16 1979-10-12 Fresenius Chem Pharm Ind Dental disinfectant compsns. - contg. silver and/or zinc sulpha-diazine as antibacterial agent
EP0241179A1 (en) * 1986-03-25 1987-10-14 Rohto Pharmaceutical Co., Ltd. Pharmaceutical composition for periodontal diseases
US5387419A (en) * 1988-03-31 1995-02-07 The University Of Michigan System for controlled release of antiarrhythmic agents
JPH02184615A (en) * 1989-01-10 1990-07-19 Obujie Kagaku Kenkyusho:Kk Dentifrice composition
EP0508524A1 (en) * 1991-04-12 1992-10-14 Unilever N.V. Use of zinc ions for the treatment of periodontitis
US5260066A (en) * 1992-01-16 1993-11-09 Srchem Incorporated Cryogel bandage containing therapeutic agent
RU2078559C1 (en) * 1993-07-05 1997-05-10 Семен Евстафьевич Манойлов Method of parodontosis treatment
JPH06154030A (en) * 1993-07-06 1994-06-03 Dentaru Kagaku Kk Antimicrobial apatite and antimicrobial resin containing the same
WO1995029664A1 (en) * 1994-05-03 1995-11-09 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
WO1996009808A1 (en) * 1994-09-26 1996-04-04 The Procter & Gamble Company Aqueous oral compositions
CZ282292B6 (en) * 1995-02-24 1997-06-11 Odbor Správy Majetku Mo Pharmaceutical preparation exhibiting antimicrobial activity
WO1997016212A1 (en) * 1995-11-01 1997-05-09 Bristol-Myers Squibb Company Water soluble films

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 128, no. 11, 16 March 1998, Columbus, Ohio, US; abstract no. 132410, DITTRICH, MILAN ET AL: "Pharmaceutical preparation exhibiting antimicrobial activity" XP002094901 *
DATABASE WPI Section Ch Week 9035, Derwent World Patents Index; Class B05, AN 90-264449, XP002094906 *
DATABASE WPI Section Ch Week 9427, Derwent World Patents Index; Class A08, AN 94-220543, XP002094902 *
DATABASE WPI Section Ch Week 9747, Derwent World Patents Index; Class B04, AN 97-510694, XP002094985 *
PATENT ABSTRACTS OF JAPAN vol. 014, no. 458 (C - 0766) 3 October 1990 (1990-10-03) *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 471 (C - 1245) 2 September 1994 (1994-09-02) *

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JP2001515042A (en) 2001-09-18
EP1011693A1 (en) 2000-06-28
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