WO1999004228A3 - Light detection device - Google Patents

Light detection device Download PDF

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Publication number
WO1999004228A3
WO1999004228A3 PCT/US1998/014575 US9814575W WO9904228A3 WO 1999004228 A3 WO1999004228 A3 WO 1999004228A3 US 9814575 W US9814575 W US 9814575W WO 9904228 A3 WO9904228 A3 WO 9904228A3
Authority
WO
WIPO (PCT)
Prior art keywords
light detection
detection device
switch mechanisms
permit
detectors
Prior art date
Application number
PCT/US1998/014575
Other languages
French (fr)
Other versions
WO1999004228A9 (en
WO1999004228A2 (en
Inventor
William G Burton
Kimberly L Crawford
Sudhir S Deshpande
Glenn R Edwards
Amer El-Hage
Todd E French
Vladimir Lemberg
Joseph S Leytes
Samuel A Marquiss
John W Meadows
Irina Mineyev
Douglas N Modlin
John C Owicki
Jon F Peterson
Derrick A Richardson
Rick V Stellmacher
Michael T Taylor
Original Assignee
Ljl Biosystems Inc
William G Burton
Kimberly L Crawford
Sudhir S Deshpande
Glenn R Edwards
El Hage Amer
Todd E French
Vladimir Lemberg
Joseph S Leytes
Samuel A Marquiss
John W Meadows
Irina Mineyev
Douglas N Modlin
John C Owicki
Jon F Peterson
Derrick A Richardson
Rick V Stellmacher
Michael T Taylor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ljl Biosystems Inc, William G Burton, Kimberly L Crawford, Sudhir S Deshpande, Glenn R Edwards, El Hage Amer, Todd E French, Vladimir Lemberg, Joseph S Leytes, Samuel A Marquiss, John W Meadows, Irina Mineyev, Douglas N Modlin, John C Owicki, Jon F Peterson, Derrick A Richardson, Rick V Stellmacher, Michael T Taylor filed Critical Ljl Biosystems Inc
Priority to JP2000503394A priority Critical patent/JP2002509235A/en
Priority to EP98935657A priority patent/EP1012579A2/en
Priority to IL13406998A priority patent/IL134069A0/en
Priority to AU84853/98A priority patent/AU8485398A/en
Priority to US09/118,310 priority patent/US6033100A/en
Priority to US09/144,575 priority patent/US6159425A/en
Priority to US09/144,578 priority patent/US6499366B1/en
Priority to US09/146,081 priority patent/US6187267B1/en
Priority to US09/160,533 priority patent/US6097025A/en
Publication of WO1999004228A2 publication Critical patent/WO1999004228A2/en
Publication of WO1999004228A3 publication Critical patent/WO1999004228A3/en
Publication of WO1999004228A9 publication Critical patent/WO1999004228A9/en
Priority to AU49990/99A priority patent/AU4999099A/en
Priority to PCT/US1999/016057 priority patent/WO2000004364A2/en
Priority to US09/629,599 priority patent/US6469311B1/en
Priority to US09/733,370 priority patent/US20010007640A1/en
Priority to US10/445,292 priority patent/US6992761B2/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/523Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • B01J2219/00317Microwell devices, i.e. having large numbers of wells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061The surface being organic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • B01J2219/00691Automatic using robots
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00702Processes involving means for analysing and characterising the products
    • B01J2219/00707Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0829Multi-well plates; Microtitration plates
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809Multifield plates or multicontainer arrays
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/113332Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/113332Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y10T436/114165Automated chemical analysis with conveyance of sample along a test line in a container or rack with step of insertion or removal from test line
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/115831Condition or time responsive
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation

Abstract

A high-throughput light detection instrument and method are described. In some embodiments, switch mechanisms (108, 136) and optical relay structures permit different light sources (103a-d) and/or detectors (145a-d) to be selected for different applications. In other embodiments, switch mechanisms (108, 136) and optical paths permit top/bottom illumination and/or top/bottom detection, or combinations thereof.
PCT/US1998/014575 1997-07-16 1998-07-15 Light detection device WO1999004228A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP2000503394A JP2002509235A (en) 1997-07-16 1998-07-15 Photodetector
EP98935657A EP1012579A2 (en) 1997-07-16 1998-07-15 Light detection device
IL13406998A IL134069A0 (en) 1997-07-16 1998-07-15 Light detection device
AU84853/98A AU8485398A (en) 1997-07-16 1998-07-15 Light detection device
US09/118,310 US6033100A (en) 1997-07-16 1998-07-16 Floating head assembly
US09/144,575 US6159425A (en) 1997-07-16 1998-08-31 Sample transporter
US09/144,578 US6499366B1 (en) 1997-07-16 1998-08-31 Sample feeder
US09/146,081 US6187267B1 (en) 1997-07-16 1998-09-02 Chemiluminescence detection device
US09/160,533 US6097025A (en) 1997-10-31 1998-09-24 Light detection device having an optical-path switching mechanism
AU49990/99A AU4999099A (en) 1998-07-15 1999-07-15 Evanescent field illumination devices and methods
PCT/US1999/016057 WO2000004364A2 (en) 1998-07-15 1999-07-15 Evanescent field illumination devices and methods
US09/629,599 US6469311B1 (en) 1997-07-16 2000-07-31 Detection device for light transmitted from a sensed volume
US09/733,370 US20010007640A1 (en) 1997-07-16 2000-12-08 Sample transporter
US10/445,292 US6992761B2 (en) 1997-09-20 2003-05-22 Broad range light detection system

Applications Claiming Priority (26)

Application Number Priority Date Filing Date Title
US5287697P 1997-07-16 1997-07-16
US60/052,876 1997-07-16
US5963997P 1997-09-20 1997-09-20
US60/059,639 1997-09-20
US6381197P 1997-10-31 1997-10-31
US60/063,811 1997-10-31
US7249998P 1998-01-26 1998-01-26
US60/072,499 1998-01-26
US7278098P 1998-01-27 1998-01-27
US60/072,780 1998-01-27
US7541498P 1998-02-20 1998-02-20
US60/075,414 1998-02-20
US7580698P 1998-02-24 1998-02-24
US60/075,806 1998-02-24
US8225398P 1998-04-17 1998-04-17
US09/062,472 1998-04-17
US60/082,253 1998-04-17
US09/062,472 US6071748A (en) 1997-07-16 1998-04-17 Light detection device
US8416798P 1998-05-04 1998-05-04
US60/084,167 1998-05-04
US8533598P 1998-05-13 1998-05-13
US60/085,335 1998-05-13
US8550098P 1998-05-14 1998-05-14
US60/085,500 1998-05-14
US8984898P 1998-06-19 1998-06-19
US60/089,848 1998-06-19

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US09/062,472 Continuation US6071748A (en) 1997-07-16 1998-04-17 Light detection device
US09/118,141 Continuation US6313960B2 (en) 1997-07-16 1998-07-16 Optical filter holder assembly

Related Child Applications (9)

Application Number Title Priority Date Filing Date
US09/062,472 Continuation US6071748A (en) 1997-07-16 1998-04-17 Light detection device
US09/118,310 Continuation US6033100A (en) 1997-07-16 1998-07-16 Floating head assembly
US09/118,141 Continuation US6313960B2 (en) 1997-07-16 1998-07-16 Optical filter holder assembly
US09/118,341 Continuation US6025985A (en) 1997-07-16 1998-07-16 Moveable control unit for high-throughput analyzer
US09/144,578 Continuation US6499366B1 (en) 1997-07-16 1998-08-31 Sample feeder
US09/144,575 Continuation US6159425A (en) 1997-07-16 1998-08-31 Sample transporter
US09/146,081 Continuation US6187267B1 (en) 1997-07-16 1998-09-02 Chemiluminescence detection device
US09/160,533 Continuation US6097025A (en) 1997-07-16 1998-09-24 Light detection device having an optical-path switching mechanism
US09/733,370 Continuation US20010007640A1 (en) 1997-07-16 2000-12-08 Sample transporter

Publications (3)

Publication Number Publication Date
WO1999004228A2 WO1999004228A2 (en) 1999-01-28
WO1999004228A3 true WO1999004228A3 (en) 1999-04-01
WO1999004228A9 WO1999004228A9 (en) 1999-07-08

Family

ID=27584468

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/014575 WO1999004228A2 (en) 1997-07-16 1998-07-15 Light detection device

Country Status (5)

Country Link
US (8) US6071748A (en)
EP (1) EP1012579A2 (en)
JP (1) JP2002509235A (en)
IL (1) IL134069A0 (en)
WO (1) WO1999004228A2 (en)

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US6071748A (en) 2000-06-06
US6499366B1 (en) 2002-12-31
JP2002509235A (en) 2002-03-26
US20010021074A1 (en) 2001-09-13
WO1999004228A9 (en) 1999-07-08
US6313960B2 (en) 2001-11-06
US6033100A (en) 2000-03-07
US6187267B1 (en) 2001-02-13
US20010007640A1 (en) 2001-07-12
US6025985A (en) 2000-02-15
EP1012579A2 (en) 2000-06-28
US6159425A (en) 2000-12-12
IL134069A0 (en) 2001-04-30
WO1999004228A2 (en) 1999-01-28

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