WO1998059285A3 - System and method for simulation, modeling and scheduling of biopharmaceutical batch process operations - Google Patents

System and method for simulation, modeling and scheduling of biopharmaceutical batch process operations Download PDF

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Publication number
WO1998059285A3
WO1998059285A3 PCT/US1998/013055 US9813055W WO9859285A3 WO 1998059285 A3 WO1998059285 A3 WO 1998059285A3 US 9813055 W US9813055 W US 9813055W WO 9859285 A3 WO9859285 A3 WO 9859285A3
Authority
WO
WIPO (PCT)
Prior art keywords
equipment
scheduling
preparation
biopharmaceutical
support operations
Prior art date
Application number
PCT/US1998/013055
Other languages
French (fr)
Other versions
WO1998059285A2 (en
Inventor
Peter G Brown
Original Assignee
Peter G Brown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peter G Brown filed Critical Peter G Brown
Priority to CA002294428A priority Critical patent/CA2294428A1/en
Priority to AU82617/98A priority patent/AU8261798A/en
Priority to EP98932817A priority patent/EP1050001A4/en
Priority to JP50499399A priority patent/JP2002518981A/en
Publication of WO1998059285A2 publication Critical patent/WO1998059285A2/en
Publication of WO1998059285A3 publication Critical patent/WO1998059285A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B17/00—Systems involving the use of models or simulators of said systems
    • G05B17/02—Systems involving the use of models or simulators of said systems electric
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B19/00—Programme-control systems
    • G05B19/02—Programme-control systems electric
    • G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS], computer integrated manufacturing [CIM]
    • G05B19/41865—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS], computer integrated manufacturing [CIM] characterised by job scheduling, process planning, material flow
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B19/00—Programme-control systems
    • G05B19/02—Programme-control systems electric
    • G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS], computer integrated manufacturing [CIM]
    • G05B19/41885—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS], computer integrated manufacturing [CIM] characterised by modeling, simulation of the manufacturing system
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q10/00—Administration; Management
    • G06Q10/06—Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00004—Scale aspects
    • B01J2219/00006—Large-scale industrial plants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00004—Scale aspects
    • B01J2219/00015—Scale-up
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00027—Process aspects
    • B01J2219/00029—Batch processes
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B2219/00—Program-control systems
    • G05B2219/30—Nc systems
    • G05B2219/32—Operator till task planning
    • G05B2219/32234—Maintenance planning
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B2219/00—Program-control systems
    • G05B2219/30—Nc systems
    • G05B2219/32—Operator till task planning
    • G05B2219/32354—Divide, analyse process into subprocesses, until elementary unit operations
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
    • Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]

Abstract

A system and method for simulation, modeling and scheduling of process support operations in a biopharmaceutical manufacturing facility. The process support operations include those associated with the batch production facility (e.g., equipment maintenance and calibration, and quality control sampling and testing). The system and method, for process support operations associated with the manufacturing facility include the steps of identifying relevant data (e.g., maintenance, calibration, or testing) associated with the biopharmaceutical production process equipment (104). After the data are identified, biopharmaceutical production process equipment is used to generate a table of equipment and associated data. The table of equipment and data is then compared with a procedure time line to determine the scheduling of the tasks for the equipment in the biopharmaceutical production process (106). For process support operations associated with the manufacturing process within the facility, the system and method include the steps of identifying the solution and its volume, or identifying the soiled equipment and its preparation procedures (108). After identification, scheduling information is identified based on solution start dates or equipment protocols (110). The duration of the solution preparation procedure is then determined based on preparation vessel assignment and the scheduling information (112). An equipment preparation time line is also generated based on the size and capacity of the preparation equipment and the scheduling information (112).
PCT/US1998/013055 1997-06-20 1998-06-22 System and method for simulation, modeling and scheduling of biopharmaceutical batch process operations WO1998059285A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002294428A CA2294428A1 (en) 1997-06-20 1998-06-22 System and method for simulation, modeling and scheduling of biopharmaceutical batch process operations
AU82617/98A AU8261798A (en) 1997-06-20 1998-06-22 System and method for simulation, modeling and scheduling of process support operations in biopharmaceutical batch process manufacturing facilities
EP98932817A EP1050001A4 (en) 1997-06-20 1998-06-22 System and method for simulation, modeling and scheduling of process support operations in biopharmaceutical batch process manufacturing facilities
JP50499399A JP2002518981A (en) 1997-06-20 1998-06-22 System and method for simulation, modeling and scheduling of process support operations in a biopharmaceutical batch process manufacturing facility

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US5029497P 1997-06-20 1997-06-20
US5029097P 1997-06-20 1997-06-20
US5028597P 1997-06-20 1997-06-20
US5029997P 1997-06-20 1997-06-20
US60/050,299 1997-06-20
US60/050,285 1997-06-20
US60/050,290 1997-06-20
US60/050,294 1997-06-20

Publications (2)

Publication Number Publication Date
WO1998059285A2 WO1998059285A2 (en) 1998-12-30
WO1998059285A3 true WO1998059285A3 (en) 1999-08-12

Family

ID=27489328

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/013055 WO1998059285A2 (en) 1997-06-20 1998-06-22 System and method for simulation, modeling and scheduling of biopharmaceutical batch process operations

Country Status (5)

Country Link
EP (1) EP1050001A4 (en)
JP (1) JP2002518981A (en)
AU (1) AU8261798A (en)
CA (1) CA2294428A1 (en)
WO (1) WO1998059285A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE485566T1 (en) * 1999-08-13 2010-11-15 Peter G Brown SIMULATION, MODELING AND PLANNING OF BATCH PROCESSING PROCESSES IN PRODUCTION FACILITIES USING PROCESS TIME INTERVALS
GB2362484B (en) * 2000-05-17 2005-02-23 Biopharm Services Ltd Methods and apparatus for simulating industrial processes
GB0219954D0 (en) * 2002-08-29 2002-10-02 Amersham Health R & D Ab Method and apparatus for producing contrast agents for magnetic resonance imaging
US7343211B2 (en) 2003-04-09 2008-03-11 Brown Peter G Use of sub (partial) cycles, nested cluster cycles, and lot cycles for determining equipment capacities in a batch manufacturing facility
CN103218256B (en) * 2013-04-18 2016-04-13 中国工商银行股份有限公司 A kind of backing method of host batch and system
US10372100B2 (en) * 2016-08-29 2019-08-06 Ge Healthcare Bio-Sciences Corp. Manufacturing system for biopharmaceutical products
CN110321288B (en) * 2019-06-21 2023-05-12 北京机电工程研究所 Simulation test method for information processing system on aircraft
CN112101701A (en) * 2020-07-28 2020-12-18 重庆华森制药股份有限公司 Intelligent manufacturing system and manufacturing method for producing polyethylene glycol electrolyte powder

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4796194A (en) * 1986-08-20 1989-01-03 Atherton Robert W Real world modeling and control process
US5164905A (en) * 1987-08-12 1992-11-17 Hitachi, Ltd. Production system with order of processing determination
US5402367A (en) * 1993-07-19 1995-03-28 Texas Instruments, Incorporated Apparatus and method for model based process control
US5495417A (en) * 1990-08-14 1996-02-27 Kabushiki Kaisha Toshiba System for automatically producing different semiconductor products in different quantities through a plurality of processes along a production line
US5737581A (en) * 1995-08-30 1998-04-07 Keane; John A. Quality system implementation simulator

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4383298A (en) * 1980-04-10 1983-05-10 Ciba-Geigy Corporation Plant maintenance control system
US5148370A (en) * 1987-06-17 1992-09-15 The Standard Oil Company Expert system and method for batch production scheduling and planning
US5079731A (en) * 1989-10-17 1992-01-07 Alcon Laboratories, Inc. Method and apparatus for process control validation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4796194A (en) * 1986-08-20 1989-01-03 Atherton Robert W Real world modeling and control process
US5164905A (en) * 1987-08-12 1992-11-17 Hitachi, Ltd. Production system with order of processing determination
US5495417A (en) * 1990-08-14 1996-02-27 Kabushiki Kaisha Toshiba System for automatically producing different semiconductor products in different quantities through a plurality of processes along a production line
US5402367A (en) * 1993-07-19 1995-03-28 Texas Instruments, Incorporated Apparatus and method for model based process control
US5737581A (en) * 1995-08-30 1998-04-07 Keane; John A. Quality system implementation simulator

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1050001A4 *

Also Published As

Publication number Publication date
JP2002518981A (en) 2002-06-25
AU8261798A (en) 1999-01-04
WO1998059285A2 (en) 1998-12-30
EP1050001A2 (en) 2000-11-08
EP1050001A4 (en) 2000-12-06
CA2294428A1 (en) 1998-12-30

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