WO1998056506A1 - Systems and methods for parallel synthesis of compounds - Google Patents
Systems and methods for parallel synthesis of compounds Download PDFInfo
- Publication number
- WO1998056506A1 WO1998056506A1 PCT/US1998/012305 US9812305W WO9856506A1 WO 1998056506 A1 WO1998056506 A1 WO 1998056506A1 US 9812305 W US9812305 W US 9812305W WO 9856506 A1 WO9856506 A1 WO 9856506A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- valve portion
- fluid
- passage
- valve
- synthesis apparatus
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title claims abstract description 57
- 238000003786 synthesis reaction Methods 0.000 title claims abstract description 56
- 238000000034 method Methods 0.000 title claims abstract description 33
- 150000001875 compounds Chemical class 0.000 title abstract description 36
- 238000006243 chemical reaction Methods 0.000 claims abstract description 129
- 239000012530 fluid Substances 0.000 claims description 74
- 238000007789 sealing Methods 0.000 claims description 31
- 239000000463 material Substances 0.000 claims description 20
- 239000013536 elastomeric material Substances 0.000 claims description 12
- 238000011010 flushing procedure Methods 0.000 claims description 4
- 230000037361 pathway Effects 0.000 claims description 2
- 230000002194 synthesizing effect Effects 0.000 abstract description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 17
- 239000010410 layer Substances 0.000 description 12
- 230000009467 reduction Effects 0.000 description 11
- 238000006722 reduction reaction Methods 0.000 description 11
- 239000007789 gas Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 8
- 239000002904 solvent Substances 0.000 description 8
- 239000000356 contaminant Substances 0.000 description 6
- 239000004809 Teflon Substances 0.000 description 5
- 229920006362 Teflon® Polymers 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 230000003647 oxidation Effects 0.000 description 5
- 238000007254 oxidation reaction Methods 0.000 description 5
- 239000007790 solid phase Substances 0.000 description 5
- 238000010532 solid phase synthesis reaction Methods 0.000 description 5
- 239000003351 stiffener Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- -1 vapors Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 150000001299 aldehydes Chemical class 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 230000029936 alkylation Effects 0.000 description 3
- 238000005804 alkylation reaction Methods 0.000 description 3
- 238000003491 array Methods 0.000 description 3
- 239000012298 atmosphere Substances 0.000 description 3
- 238000009833 condensation Methods 0.000 description 3
- 230000005494 condensation Effects 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005755 formation reaction Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 150000002894 organic compounds Chemical class 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 238000007363 ring formation reaction Methods 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- 238000005727 Friedel-Crafts reaction Methods 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229910001882 dioxygen Inorganic materials 0.000 description 2
- 230000026030 halogenation Effects 0.000 description 2
- 238000005658 halogenation reaction Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 230000016507 interphase Effects 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 238000010647 peptide synthesis reaction Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 239000011241 protective layer Substances 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000013022 venting Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- 241001227713 Chiron Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 238000003512 Claisen condensation reaction Methods 0.000 description 1
- 238000005698 Diels-Alder reaction Methods 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- 238000005967 Finkelstein reaction Methods 0.000 description 1
- 238000007341 Heck reaction Methods 0.000 description 1
- 238000006546 Horner-Wadsworth-Emmons reaction Methods 0.000 description 1
- 229920004459 Kel-F® PCTFE Polymers 0.000 description 1
- 238000006000 Knoevenagel condensation reaction Methods 0.000 description 1
- 238000006683 Mannich reaction Methods 0.000 description 1
- 238000006845 Michael addition reaction Methods 0.000 description 1
- 238000006751 Mitsunobu reaction Methods 0.000 description 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 1
- 108010067902 Peptide Library Proteins 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 238000005598 Sharpless reaction Methods 0.000 description 1
- 238000006619 Stille reaction Methods 0.000 description 1
- 238000006069 Suzuki reaction reaction Methods 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000005575 aldol reaction Methods 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 150000001345 alkine derivatives Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- UUAGAQFQZIEFAH-UHFFFAOYSA-N chlorotrifluoroethylene Chemical compound FC(F)=C(F)Cl UUAGAQFQZIEFAH-UHFFFAOYSA-N 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000006352 cycloaddition reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 150000001993 dienes Chemical class 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 238000012912 drug discovery process Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000006735 epoxidation reaction Methods 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000011491 glass wool Substances 0.000 description 1
- 239000002241 glass-ceramic Substances 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 238000007210 heterogeneous catalysis Methods 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000006263 metalation reaction Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000006396 nitration reaction Methods 0.000 description 1
- 238000005935 nucleophilic addition reaction Methods 0.000 description 1
- 230000000269 nucleophilic effect Effects 0.000 description 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 238000010653 organometallic reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000005932 reductive alkylation reaction Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000012508 resin bead Substances 0.000 description 1
- 150000003333 secondary alcohols Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 238000003746 solid phase reaction Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000006277 sulfonation reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B39/00—Halogenation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00283—Reactor vessels with top opening
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
- B01J2219/0031—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks the racks or blocks being mounted in stacked arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00331—Details of the reactor vessels
- B01J2219/00333—Closures attached to the reactor vessels
- B01J2219/00344—Caps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00364—Pipettes
- B01J2219/00367—Pipettes capillary
- B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00389—Feeding through valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00479—Means for mixing reactants or products in the reaction vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00479—Means for mixing reactants or products in the reaction vessels
- B01J2219/00481—Means for mixing reactants or products in the reaction vessels by the use of moving stirrers within the reaction vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00479—Means for mixing reactants or products in the reaction vessels
- B01J2219/00484—Means for mixing reactants or products in the reaction vessels by shaking, vibrating or oscillating of the reaction vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00479—Means for mixing reactants or products in the reaction vessels
- B01J2219/00493—Means for mixing reactants or products in the reaction vessels by sparging or bubbling with gases
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00495—Means for heating or cooling the reaction vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00689—Automatic using computers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98932748A EP1005395A1 (en) | 1997-06-11 | 1998-06-11 | Systems and methods for parallel synthesis of compounds |
AU82560/98A AU8256098A (en) | 1997-06-11 | 1998-06-11 | Systems and methods for parallel synthesis of compounds |
JP50328199A JP2002504017A (en) | 1997-06-11 | 1998-06-11 | Systems and methods for parallel synthesis of compounds |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4919897P | 1997-06-11 | 1997-06-11 | |
US60/049,198 | 1997-06-11 | ||
US6313497P | 1997-10-22 | 1997-10-22 | |
US60/063,134 | 1997-10-22 | ||
US09/095,731 | 1998-06-10 | ||
US09/095,731 US6190619B1 (en) | 1997-06-11 | 1998-06-10 | Systems and methods for parallel synthesis of compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998056506A1 true WO1998056506A1 (en) | 1998-12-17 |
WO1998056506A9 WO1998056506A9 (en) | 1999-04-08 |
Family
ID=27367496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/012305 WO1998056506A1 (en) | 1997-06-11 | 1998-06-11 | Systems and methods for parallel synthesis of compounds |
Country Status (5)
Country | Link |
---|---|
US (1) | US6190619B1 (en) |
EP (1) | EP1005395A1 (en) |
JP (1) | JP2002504017A (en) |
AU (1) | AU8256098A (en) |
WO (1) | WO1998056506A1 (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0916397A2 (en) * | 1997-11-14 | 1999-05-19 | Rohm And Haas Company | Apparatus and method used in multiple, simultaneous synthesis of general compounds |
EP0933132A2 (en) * | 1998-02-02 | 1999-08-04 | Toyo Boseki Kabushiki Kaisha | Nucleic Acid Extraction Apparatus |
WO2001000315A2 (en) * | 1999-06-25 | 2001-01-04 | Avantium International B.V. | Reactor vessel array |
US6258323B1 (en) | 1998-11-16 | 2001-07-10 | Rohm And Haas Company | Apparatus and method used in multiple, simultaneous synthesis of general compounds |
US6395235B1 (en) | 1998-08-21 | 2002-05-28 | Argonaut Technologies, Inc. | Devices and methods for accessing reaction vessels |
US6410643B1 (en) | 2000-03-09 | 2002-06-25 | Surmodics, Inc. | Solid phase synthesis method and reagent |
US6813499B2 (en) | 2000-03-25 | 2004-11-02 | Hewlett-Packard Development Company, L.P. | Providing location data about a mobile entity |
US6875604B2 (en) | 2000-02-02 | 2005-04-05 | Applera Corporation | Thermal cycling device with mechanism for ejecting sample well trays |
US6925288B2 (en) | 2000-04-01 | 2005-08-02 | Hewlett-Packard Development Company, L.P. | Gathering information from short-range wireless portals |
USRE39566E1 (en) | 1999-09-29 | 2007-04-17 | Applera Corporation | Thermocycler and lifting element |
Families Citing this family (117)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
US6777217B1 (en) * | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
EP0989907B1 (en) * | 1997-06-16 | 2002-01-09 | Chemspeed Ltd. | Device for conducting a plurality of chemical, biochemical or physical procedures in parallel |
US6043097A (en) * | 1997-12-05 | 2000-03-28 | Bayer Corporation | Reagent package |
US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
US20020119579A1 (en) * | 1998-07-14 | 2002-08-29 | Peter Wagner | Arrays devices and methods of use thereof |
US6780582B1 (en) * | 1998-07-14 | 2004-08-24 | Zyomyx, Inc. | Arrays of protein-capture agents and methods of use thereof |
US6913934B2 (en) * | 1998-08-13 | 2005-07-05 | Symyx Technologies, Inc. | Apparatus and methods for parallel processing of multiple reaction mixtures |
US6864092B1 (en) * | 1998-08-13 | 2005-03-08 | Symyx Technologies, Inc. | Parallel reactor with internal sensing and method of using same |
US6361749B1 (en) * | 1998-08-18 | 2002-03-26 | Immunivest Corporation | Apparatus and methods for magnetic separation |
US6410332B1 (en) * | 1998-09-08 | 2002-06-25 | Symyx Technologies, Inc. | Sampling and analysis of reactions by trapping reaction components on a sorbent |
JP2000225334A (en) * | 1999-02-04 | 2000-08-15 | Shimadzu Corp | Apparatus for automatic synthesis |
US6770482B1 (en) * | 1999-07-16 | 2004-08-03 | General Electric | Method and apparatus for rapid screening of multiphase reactions |
US6576196B1 (en) * | 1999-12-15 | 2003-06-10 | Uop Llc | Multiple parallel catalytic reactor assembly |
US6770245B2 (en) * | 1999-12-15 | 2004-08-03 | Uop Llc | Multiple parallel processing assembly |
US7435392B2 (en) * | 2000-02-03 | 2008-10-14 | Acclavis, Llc | Scalable continuous production system |
US20030129724A1 (en) * | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
US8399383B2 (en) * | 2000-05-04 | 2013-03-19 | Yale University | Protein chips for high throughput screening of protein activity |
US6994827B2 (en) * | 2000-06-03 | 2006-02-07 | Symyx Technologies, Inc. | Parallel semicontinuous or continuous reactors |
WO2001094909A1 (en) * | 2000-06-09 | 2001-12-13 | Cueni Hansjoerg | Valve arrangement |
US7018589B1 (en) * | 2000-07-19 | 2006-03-28 | Symyx Technologies, Inc. | High pressure parallel reactor |
EP1207396A1 (en) * | 2000-10-20 | 2002-05-22 | Seyonic SA | Fluid dispenser |
US20020090336A1 (en) * | 2001-01-08 | 2002-07-11 | General Electric Company | Device and method for normalizing gas flow through multiple reaction vessels |
US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US6767514B2 (en) * | 2001-03-05 | 2004-07-27 | Baskerville Reactors And Autoclaves Limited | Test apparatus |
US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US6692708B2 (en) * | 2001-04-05 | 2004-02-17 | Symyx Technologies, Inc. | Parallel reactor for sampling and conducting in situ flow-through reactions and a method of using same |
US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
WO2002099003A2 (en) * | 2001-06-06 | 2002-12-12 | Monsanto Technology Llc | Parallel reactor system and method |
US7282182B2 (en) * | 2001-07-20 | 2007-10-16 | Gen-Probe Incorporated | Sample carrier |
CA2455181C (en) * | 2001-08-01 | 2010-04-06 | Merck & Co., Inc. | Benzimidazo[4,5-f]isoquinolinone derivatives |
US20050043421A1 (en) * | 2001-08-29 | 2005-02-24 | Van Der Wal Hanno R | Process to manufacture polyurethane products using polymer polyols in which the carrier polyol is a tertiary amone based polyol |
US6783737B2 (en) * | 2002-01-25 | 2004-08-31 | Bristol-Myers Squibb Company | High pressure chemistry reactor |
US6902704B2 (en) * | 2002-02-28 | 2005-06-07 | Equistar Chemicals, L.P | Injection pump assembly for a combinatorial reactor and related method |
ATE375823T1 (en) * | 2002-05-17 | 2007-11-15 | Gen Probe Inc | SAMPLE CARRIER WITH RELEASABLE LOCKING DEVICE |
JP4235171B2 (en) | 2002-05-17 | 2009-03-11 | ジェン−プロウブ インコーポレイテッド | Sample carrier with sample tube blocking means and drip shield for use therewith |
GB0225631D0 (en) * | 2002-07-05 | 2002-12-11 | Aventis Pharma Inc | Apparatus and method for use in solid phase chemical synthesis |
JP2006513835A (en) * | 2002-07-05 | 2006-04-27 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | Apparatus and method used for solid phase chemical synthesis |
WO2004013290A2 (en) * | 2002-08-05 | 2004-02-12 | Invitrogen Corporation | Compositions and methods for molecular biology |
US20050233473A1 (en) * | 2002-08-16 | 2005-10-20 | Zyomyx, Inc. | Methods and reagents for surface functionalization |
FI114033B (en) * | 2002-10-17 | 2004-07-30 | Metso Paper Inc | Method and system for coating production |
US7169602B2 (en) * | 2002-12-04 | 2007-01-30 | Applera Corporation | Sample substrate for use in biological testing and method for filling a sample substrate |
US20040136873A1 (en) * | 2003-01-09 | 2004-07-15 | Argonaut Technologies, Inc. | Modular reactor system |
US20070178456A1 (en) | 2003-03-27 | 2007-08-02 | Trotta Christopher R | Targeting enzymes of the trna splicing pathway for identification of anti-fungal and/or anti-proliferative molecules |
EP2319318A3 (en) | 2003-03-27 | 2011-08-17 | PTC Therapeutics, Inc. | Methods of identifying compounds that target TRNA splicing endonuclease and uses of said compounds as anti-proliferative agents |
US20040248323A1 (en) * | 2003-06-09 | 2004-12-09 | Protometrix, Inc. | Methods for conducting assays for enzyme activity on protein microarrays |
WO2005011867A2 (en) | 2003-07-31 | 2005-02-10 | Handylab, Inc. | Processing particle-containing samples |
WO2005014795A2 (en) | 2003-08-08 | 2005-02-17 | Genenews Inc. | Osteoarthritis biomarkers and uses thereof |
US20050169816A1 (en) * | 2003-12-15 | 2005-08-04 | Kirshner Brian M. | Automated oligomer synthesis |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
SE528164C2 (en) * | 2004-12-22 | 2006-09-19 | Foss Analytical Ab | Collection device for connection to at least one test tube |
CA2599589A1 (en) | 2005-02-07 | 2006-08-17 | Genenews,Inc. | Mild osteoarthritis biomarkers and uses thereof |
CA2937005A1 (en) | 2005-03-22 | 2006-09-28 | President And Fellows Of Harvard College | Treatment of protein degradation disorders |
US7910067B2 (en) | 2005-04-19 | 2011-03-22 | Gen-Probe Incorporated | Sample tube holder |
US8249814B2 (en) | 2005-10-21 | 2012-08-21 | Genenews Inc. | Method, computer readable medium, and system for determining a probability of colorectal cancer in a test subject |
AU2007214458C1 (en) | 2006-02-14 | 2012-12-06 | Dana-Farber Cancer Institute, Inc. | Histone deacetylase inhibitors |
WO2008091349A1 (en) * | 2006-02-14 | 2008-07-31 | The President And Fellows Of Harvard College | Bifunctional histone deacetylase inhibitors |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
WO2007112114A2 (en) | 2006-03-24 | 2007-10-04 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US7998708B2 (en) * | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
JP5497431B2 (en) * | 2006-05-03 | 2014-05-21 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Histone deacetylase and tubulin deacetylase inhibitors |
JP4938370B2 (en) * | 2006-06-30 | 2012-05-23 | 株式会社サカエ | Automatic analyzer |
EP2091647A2 (en) | 2006-11-14 | 2009-08-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US8703492B2 (en) * | 2007-04-06 | 2014-04-22 | Qiagen Gaithersburg, Inc. | Open platform hybrid manual-automated sample processing system |
US20080286170A1 (en) * | 2007-05-14 | 2008-11-20 | Symyx Technologies, Inc. | Parallel batch reactor |
US7807109B2 (en) | 2007-05-14 | 2010-10-05 | Freeslate, Inc. | Parallel batch reactor with pressure monitoring |
US7655191B2 (en) * | 2007-05-14 | 2010-02-02 | Symyx Solutions, Inc. | Methods for chemical reactions in a parallel batch reactor |
US20090136385A1 (en) * | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube |
US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US8133671B2 (en) * | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
USD621060S1 (en) | 2008-07-14 | 2010-08-03 | Handylab, Inc. | Microfluidic cartridge |
US8324372B2 (en) | 2007-07-13 | 2012-12-04 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
AU2015234322B2 (en) * | 2007-07-13 | 2017-10-12 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US9618139B2 (en) * | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
USD618820S1 (en) | 2008-07-11 | 2010-06-29 | Handylab, Inc. | Reagent holder |
USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
CA2731730C (en) * | 2008-07-23 | 2017-06-13 | President And Fellows Of Harvard College | Deacetylase inhibitors and uses thereof |
WO2011019393A2 (en) | 2009-08-11 | 2011-02-17 | President And Fellows Of Harvard College | Class- and isoform-specific hdac inhibitors and uses thereof |
US9953141B2 (en) | 2009-11-18 | 2018-04-24 | Becton, Dickinson And Company | Laboratory central control unit method and system |
US20130189772A1 (en) * | 2010-04-30 | 2013-07-25 | Seemab Shaikh | Multiwell-plate reactor and system therefor |
US9144801B2 (en) * | 2010-08-31 | 2015-09-29 | Abbott Laboratories | Sample tube racks having retention bars |
WO2012142516A1 (en) | 2011-04-15 | 2012-10-18 | Becton, Dickinson And Company | Scanning real-time microfluidic thermo-cycler and methods for synchronized thermocycling and scanning optical detection |
US20130274144A1 (en) * | 2011-08-29 | 2013-10-17 | The Board Of Trustees Of The University Of Illiois | Compounds, reactions, and screening methods |
USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
ES2825905T3 (en) | 2011-09-30 | 2021-05-17 | Becton Dickinson Co | Unified test strip |
WO2013067202A1 (en) | 2011-11-04 | 2013-05-10 | Handylab, Inc. | Polynucleotide sample preparation device |
CN107881219B (en) | 2012-02-03 | 2021-09-10 | 贝克顿·迪金森公司 | External file for molecular diagnostic test assignment and compatibility determination between tests |
USD962471S1 (en) | 2013-03-13 | 2022-08-30 | Abbott Laboratories | Reagent container |
US9535082B2 (en) | 2013-03-13 | 2017-01-03 | Abbott Laboratories | Methods and apparatus to agitate a liquid |
USD978375S1 (en) | 2013-03-13 | 2023-02-14 | Abbott Laboratories | Reagent container |
US10058866B2 (en) | 2013-03-13 | 2018-08-28 | Abbott Laboratories | Methods and apparatus to mitigate bubble formation in a liquid |
EP3055698B1 (en) * | 2013-10-07 | 2019-05-01 | Access Medical Systems, Ltd. | Cartridge assembly tray for immunoassay tests |
US9682123B2 (en) | 2013-12-20 | 2017-06-20 | The Trustees Of Columbia University In The City Of New York | Methods of treating metabolic disease |
USD782062S1 (en) * | 2015-06-25 | 2017-03-21 | Abbott Laboratories | Reagent kit with multiple bottles |
USD782063S1 (en) * | 2015-06-25 | 2017-03-21 | Abbott Laboratories | Reagent kit with multiple bottles |
USD782061S1 (en) * | 2015-06-25 | 2017-03-21 | Abbott Laboratories | Reagent kit with multiple bottles |
USD782060S1 (en) * | 2015-06-25 | 2017-03-21 | Abbott Laboratories | Reagent kit with multiple bottles |
USD810959S1 (en) * | 2015-09-29 | 2018-02-20 | Bd Kiestra B.V. | Cuvette tray |
EP3167962B1 (en) | 2015-11-16 | 2022-05-11 | Beckman Coulter, Inc. | Sample tube rack and sample tube analysing system |
USD808039S1 (en) * | 2016-05-13 | 2018-01-16 | Becton, Dickinson And Company | Reagent plate |
USD838380S1 (en) | 2016-05-13 | 2019-01-15 | Becton, Dickinson And Company | Reagent plate |
USD812243S1 (en) | 2016-07-28 | 2018-03-06 | Beckman Coulter, Inc. | Sample tube rack |
USD808540S1 (en) * | 2016-07-28 | 2018-01-23 | Beckman Coulter, Inc. | Sample tube rack |
US20180209921A1 (en) * | 2017-01-20 | 2018-07-26 | Mallinckrodt Nuclear Medicine Llc | Systems and methods for assaying an eluate of a radionuclide generator |
USD938612S1 (en) | 2017-06-16 | 2021-12-14 | Beckman Coulter, Inc. | Sample rack |
MX2020008680A (en) | 2018-02-21 | 2020-09-25 | Ai Therapeutics Inc | Combination therapy with apilimod and glutamatergic agents. |
USD923815S1 (en) | 2019-07-10 | 2021-06-29 | Becton, Dickinson And Company | Reagent plate |
US10751713B1 (en) * | 2020-05-21 | 2020-08-25 | Sani-Tech West, Inc. | Fluid distribution system |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5424038A (en) * | 1992-09-22 | 1995-06-13 | Sotax Ag | Specimen collector |
US5565171A (en) * | 1993-05-28 | 1996-10-15 | Governors Of The University Of Alberta | Continuous biochemical reactor for analysis of sub-picomole quantities of complex organic molecules |
US5605666A (en) * | 1993-04-16 | 1997-02-25 | Beckman Instruments, Inc. | Capillary retaining system |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2961228A (en) * | 1957-12-13 | 1960-11-22 | Diamond Alkali Co | Crucible for analytic purposes having a rotary cover valving arrangement |
US3855997A (en) * | 1973-07-11 | 1974-12-24 | Cinco Medical Health Supply Co | Sterile specimen trap |
SE451164B (en) | 1982-03-22 | 1987-09-07 | Erik Ohlin | DEVICE AND SET FOR SERIAL DILUTION OF A SAMPLE LIQUID |
CH674580A5 (en) * | 1983-10-06 | 1990-06-15 | Contraves Ag | |
US4538653A (en) * | 1984-12-04 | 1985-09-03 | Genoa Group Inc. | Closure and valve for liquid container |
US4773446A (en) * | 1986-08-27 | 1988-09-27 | Porton Instruments, Inc. | Valve block assembly |
US5019348A (en) | 1988-05-26 | 1991-05-28 | Beckman Instruments, Inc. | Automated chemical conversion unit in a peptide/protein sequenator |
US5503805A (en) | 1993-11-02 | 1996-04-02 | Affymax Technologies N.V. | Apparatus and method for parallel coupling reactions |
JPH08168872A (en) * | 1994-07-22 | 1996-07-02 | Mannesmann Ag | Rotating closing device for tap hole in bottom surface of metallurgical vessle |
JP3481705B2 (en) | 1994-12-12 | 2003-12-22 | 株式会社モリテックス | Automatic solid-phase extraction device |
US5888830A (en) * | 1995-09-22 | 1999-03-30 | Berlex Laboratories, Inc. | Apparatus and process for multiple chemical reactions |
US5866342A (en) * | 1996-09-27 | 1999-02-02 | Glaxo Group Limited | Systems and methods for the synthesis of organic compounds |
US5762881A (en) * | 1996-10-29 | 1998-06-09 | Bohdan Automation, Inc. | Apparatus for multiple, simultaneous synthesis of organic compounds |
-
1998
- 1998-06-10 US US09/095,731 patent/US6190619B1/en not_active Expired - Fee Related
- 1998-06-11 JP JP50328199A patent/JP2002504017A/en not_active Ceased
- 1998-06-11 EP EP98932748A patent/EP1005395A1/en not_active Withdrawn
- 1998-06-11 WO PCT/US1998/012305 patent/WO1998056506A1/en not_active Application Discontinuation
- 1998-06-11 AU AU82560/98A patent/AU8256098A/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5424038A (en) * | 1992-09-22 | 1995-06-13 | Sotax Ag | Specimen collector |
US5605666A (en) * | 1993-04-16 | 1997-02-25 | Beckman Instruments, Inc. | Capillary retaining system |
US5565171A (en) * | 1993-05-28 | 1996-10-15 | Governors Of The University Of Alberta | Continuous biochemical reactor for analysis of sub-picomole quantities of complex organic molecules |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0916397A3 (en) * | 1997-11-14 | 1999-05-26 | Rohm And Haas Company | Apparatus and method used in multiple, simultaneous synthesis of general compounds |
EP0916397A2 (en) * | 1997-11-14 | 1999-05-19 | Rohm And Haas Company | Apparatus and method used in multiple, simultaneous synthesis of general compounds |
US6281008B1 (en) | 1998-02-02 | 2001-08-28 | Toyo Boseki Kabushiki Kaisha | Nucleic acid extraction apparatus |
EP0933132A2 (en) * | 1998-02-02 | 1999-08-04 | Toyo Boseki Kabushiki Kaisha | Nucleic Acid Extraction Apparatus |
EP0933132A3 (en) * | 1998-02-02 | 2000-12-06 | Toyo Boseki Kabushiki Kaisha | Nucleic Acid Extraction Apparatus |
US6255478B1 (en) | 1998-02-02 | 2001-07-03 | Toyo Boseki Kabushiki Kaisha | Nucleic acid extraction method |
US6395235B1 (en) | 1998-08-21 | 2002-05-28 | Argonaut Technologies, Inc. | Devices and methods for accessing reaction vessels |
US6258323B1 (en) | 1998-11-16 | 2001-07-10 | Rohm And Haas Company | Apparatus and method used in multiple, simultaneous synthesis of general compounds |
WO2001000315A2 (en) * | 1999-06-25 | 2001-01-04 | Avantium International B.V. | Reactor vessel array |
WO2001000315A3 (en) * | 1999-06-25 | 2001-03-15 | Avantium Int Bv | Reactor vessel array |
USRE39566E1 (en) | 1999-09-29 | 2007-04-17 | Applera Corporation | Thermocycler and lifting element |
US6875604B2 (en) | 2000-02-02 | 2005-04-05 | Applera Corporation | Thermal cycling device with mechanism for ejecting sample well trays |
US7169355B1 (en) | 2000-02-02 | 2007-01-30 | Applera Corporation | Apparatus and method for ejecting sample well trays |
US6410643B1 (en) | 2000-03-09 | 2002-06-25 | Surmodics, Inc. | Solid phase synthesis method and reagent |
US6813499B2 (en) | 2000-03-25 | 2004-11-02 | Hewlett-Packard Development Company, L.P. | Providing location data about a mobile entity |
US6925288B2 (en) | 2000-04-01 | 2005-08-02 | Hewlett-Packard Development Company, L.P. | Gathering information from short-range wireless portals |
Also Published As
Publication number | Publication date |
---|---|
WO1998056506A9 (en) | 1999-04-08 |
AU8256098A (en) | 1998-12-30 |
JP2002504017A (en) | 2002-02-05 |
EP1005395A1 (en) | 2000-06-07 |
US6190619B1 (en) | 2001-02-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6190619B1 (en) | Systems and methods for parallel synthesis of compounds | |
US6126904A (en) | Apparatus and methods for the preparation of chemical compounds | |
US6258323B1 (en) | Apparatus and method used in multiple, simultaneous synthesis of general compounds | |
AU705808B2 (en) | Methods and apparatus for the generation of chemical libraries | |
US6309608B1 (en) | Method and apparatus for organic synthesis | |
US7141218B2 (en) | High pressure parallel reactor with individually isolatable vessels | |
US6171555B1 (en) | Reaction block docking station | |
EP1272856B1 (en) | System and method for dispensing solution to a multi-well container | |
US8158085B2 (en) | Multi-well rotary synthesizer | |
CA2253164A1 (en) | Apparatus and method used in multiple, simultaneous synthesis of general compounds | |
WO1999020395A9 (en) | Systems and methods for combinatorial organic synthesis of arrays of reaction | |
US6395235B1 (en) | Devices and methods for accessing reaction vessels | |
CA2459241C (en) | Sealing system with flow channels | |
US7122159B2 (en) | High pressure parallel reactor with individually sealable vessels | |
US20030055295A1 (en) | Method for screening multiple reactants and catalyst systems using incremental flow reactor methodology | |
US20050047976A1 (en) | Method and apparatus for solid or solution phase reaction under ambient or inert conditions | |
Antonenko | Automation in combinatorial chemistry | |
CA2614880C (en) | Vial |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: C2 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: C2 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
COP | Corrected version of pamphlet |
Free format text: PAGES 1/11-11/11, DRAWINGS, REPLACED BY NEW PAGES 1/11-11/11; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 1998932748 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 1998932748 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: CA |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1998932748 Country of ref document: EP |