WO1998054228A3 - Amide containing molecular imprinted polymers - Google Patents

Amide containing molecular imprinted polymers Download PDF

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Publication number
WO1998054228A3
WO1998054228A3 PCT/US1998/009912 US9809912W WO9854228A3 WO 1998054228 A3 WO1998054228 A3 WO 1998054228A3 US 9809912 W US9809912 W US 9809912W WO 9854228 A3 WO9854228 A3 WO 9854228A3
Authority
WO
WIPO (PCT)
Prior art keywords
amide
mips
imprinted polymers
containing molecular
amide containing
Prior art date
Application number
PCT/US1998/009912
Other languages
French (fr)
Other versions
WO1998054228A2 (en
Inventor
Klaus Mosbach
Cong Yu
Original Assignee
Igen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25347335&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1998054228(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Igen Inc filed Critical Igen Inc
Priority to EP98926040A priority Critical patent/EP0988544A2/en
Priority to AU77966/98A priority patent/AU7796698A/en
Publication of WO1998054228A2 publication Critical patent/WO1998054228A2/en
Publication of WO1998054228A3 publication Critical patent/WO1998054228A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00Separation of optically-active compounds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26Synthetic macromolecular compounds
    • B01J20/268Polymers created by use of a template, e.g. molecularly imprinted polymers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2600/00Assays involving molecular imprinted polymers/polymers created around a molecular template

Abstract

This invention relates to molecularly imprinted polymers (MIPs) using an amide as the hydrogen bonding functional group. The amide MIPs made according to this invention exhibited enantiomeric recognition of the imprinted species when evaluated by high performance liquid chromatography (HPLC) even in an aqueous phase. In addition, the amide MIPs demonstrated improved enantiomeric resolution and load capacity.
PCT/US1998/009912 1997-05-30 1998-05-27 Amide containing molecular imprinted polymers WO1998054228A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP98926040A EP0988544A2 (en) 1997-05-30 1998-05-27 Amide containing molecular imprinted polymers
AU77966/98A AU7796698A (en) 1997-05-30 1998-05-27 Amide containing molecular imprinted polymers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/866,309 1997-05-30
US08/866,309 US6274686B1 (en) 1997-05-30 1997-05-30 Amide containing molecular imprinted polymers

Publications (2)

Publication Number Publication Date
WO1998054228A2 WO1998054228A2 (en) 1998-12-03
WO1998054228A3 true WO1998054228A3 (en) 1999-03-04

Family

ID=25347335

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/009912 WO1998054228A2 (en) 1997-05-30 1998-05-27 Amide containing molecular imprinted polymers

Country Status (4)

Country Link
US (1) US6274686B1 (en)
EP (1) EP0988544A2 (en)
AU (1) AU7796698A (en)
WO (1) WO1998054228A2 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7885697B2 (en) 2004-07-13 2011-02-08 Dexcom, Inc. Transcutaneous analyte sensor
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US7041468B2 (en) 2001-04-02 2006-05-09 Therasense, Inc. Blood glucose tracking apparatus and methods
US6780323B2 (en) * 2001-10-16 2004-08-24 The Johns Hopkins University Polymer based permeable membrane for removal of ions
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
US9247901B2 (en) 2003-08-22 2016-02-02 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US7651596B2 (en) 2005-04-08 2010-01-26 Dexcom, Inc. Cellulosic-based interference domain for an analyte sensor
US8423113B2 (en) 2003-07-25 2013-04-16 Dexcom, Inc. Systems and methods for processing sensor data
US7761130B2 (en) 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8275437B2 (en) 2003-08-01 2012-09-25 Dexcom, Inc. Transcutaneous analyte sensor
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US8160669B2 (en) 2003-08-01 2012-04-17 Dexcom, Inc. Transcutaneous analyte sensor
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
EP2239566B1 (en) 2003-12-05 2014-04-23 DexCom, Inc. Calibration techniques for a continuous analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
JP4315337B2 (en) 2004-01-16 2009-08-19 オルガノ株式会社 Non-particulate organic porous material having optical resolution and method for producing the same
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US7857760B2 (en) 2004-07-13 2010-12-28 Dexcom, Inc. Analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
US20060016700A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
US7783333B2 (en) 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
EP1991110B1 (en) 2006-03-09 2018-11-07 DexCom, Inc. Systems and methods for processing analyte sensor data
CN101415808B (en) * 2006-04-10 2011-10-05 R.J.雷诺兹烟草公司 Method for selectively removing safrole from myristica oil
WO2007143225A2 (en) 2006-06-07 2007-12-13 Abbott Diabetes Care, Inc. Analyte monitoring system and method
US20110079075A1 (en) * 2009-10-02 2011-04-07 Honeywell International Inc. Molecular imprinted three-dimensionally ordered macroporous sensor and method of forming the same
DE102014008135A1 (en) 2014-06-06 2015-12-17 Gfl Gesellschaft Für Lebensmittel-Forschung Mbh Method for analytical authenticity testing of ingredients in food using artificial antibodies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE502280C2 (en) 1991-12-20 1995-09-25 Bio Swede Ab Separation of amino acids, amino acid-based monomer and process for their preparation as well as polymeric material and process for their preparation
US5630978A (en) * 1995-06-07 1997-05-20 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Preparation of biologically active molecules by molecular imprinting
US5728296A (en) 1996-03-20 1998-03-17 Bio-Rad Laboratories, Inc. Selective recognition of solutes in chromatographic media by artificially created affinity

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BEACH J V ET AL: "DESIGNED CATALYSTS. A SYNTHETIC NETWORK POLYMER THAT CATALYZES THE DEHYDROFLUORINATION OF 4-FLUORO-4-(P-NITROPHENYL)BUTAN-2-ONE", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 116, no. 1, 12 January 1994 (1994-01-12), pages 379/380, XP000417714 *
C YU, K MOSBACH: "Molecular Imprinting Utilizing an Amide Functional Group for Hydrogen Bonding Leading to Highly Efficient Polymers", JOURNAL OF ORGANIC CHEMISTRY, vol. 62, no. 12, 1997, pages 4057 - 4064, XP002082388 *
K J SHEA: "Molecular Imprinting of Synthetic Network Polymers: The De Novo Synthesis of Macromolecular Binding and Catalytic Sites", TRENDS IN POLYMER SCIENCE, vol. 2, no. 5, May 1994 (1994-05-01), pages 166 - 173, XP002082395 *
K MOSBACH: "Molecular Imprinting", TRENDS IN BIOCHEMICAL SCIENCES (TIBS), vol. 19, January 1994 (1994-01-01), pages 9 - 14, XP002082394 *
K OHKUBO, Y FUNAKOSHI, T SAGAWA: "Catalytic activity of a novel water-soluble cross-linked olymer imprinted by a transition-state analogue for the stereoselctive hydrolysis of enantiomeric amino acid esters", POLYMER, vol. 37, no. 17, 1996, pages 3993 - 3995, XP002082391 *
K OHKUBO, Y URATA, S HIROTA, Y FUNAKOSHI, T SAGAWA, S USUI, K YOSHINAGA: "Catalytic activities of novel L-histidyl group-introduced polymers imprinted by a transition state analogue in the hydrolysis of amino acid esters", JOURNAL OF MOLECULAR CATALYSIS A:CHEMICAL, vol. 101, no. 2, 11 August 1995 (1995-08-11), pages L111 - L114, XP002082390 *
L ANDERSSON, B SELLERGREN, K MOSBACH: "Imprinting of Amino Acid Derivatives in Macroporous Polymers", TETRAHEDRON LETTERS, vol. 25, no. 45, 1984, pages 5211 - 5214, XP002082393 *
M BUROW, N MINOURA: "Molecular Imprinting: Synthesis of Polymer Particles with Antibody-like Binding Characteristics for Glucose Oxidase", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 227, no. 2, 1996, pages 419 - 422, XP002082389 *
O RAMSTRÖM, L I ANDERSSON, K MOSBACH: "Recognition Sites Incorporating Both Pyridinyl and Carboxy Functionalities Prepared by Molecular Imprinting", JOURNAL OF ORGANIC CHEMISTRY, vol. 58, no. 26, 1993, pages 7562 - 7564, XP002082392 *
SHEA K J ET AL: "SYNTHESIS AND CHARACTERIZATION OF HIGHLY CROSS-LINKED POLYACRYLAMIDES AND POLYMETHACRYLAMIDES. A NEW CLASS OF MACROPOROUS POLYAMIDES", MACROMOLECULES, vol. 23, no. 21, 15 October 1990 (1990-10-15), pages 4497 - 4507, XP000174799 *

Also Published As

Publication number Publication date
WO1998054228A2 (en) 1998-12-03
EP0988544A2 (en) 2000-03-29
US6274686B1 (en) 2001-08-14
AU7796698A (en) 1998-12-30

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