WO1998053759A2 - Carotid stent - Google Patents

Carotid stent Download PDF

Info

Publication number
WO1998053759A2
WO1998053759A2 PCT/US1998/011448 US9811448W WO9853759A2 WO 1998053759 A2 WO1998053759 A2 WO 1998053759A2 US 9811448 W US9811448 W US 9811448W WO 9853759 A2 WO9853759 A2 WO 9853759A2
Authority
WO
WIPO (PCT)
Prior art keywords
stent
section
distal
carotid artery
lateral opening
Prior art date
Application number
PCT/US1998/011448
Other languages
French (fr)
Inventor
Jay S. Yadav
Original Assignee
Yadav Jay S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yadav Jay S filed Critical Yadav Jay S
Priority to AU78131/98A priority Critical patent/AU7813198A/en
Publication of WO1998053759A2 publication Critical patent/WO1998053759A2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/856—Single tubular stent with a side portal passage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers

Definitions

  • This invention relates to stents useful in cardiovascular applications. More particularly, this invention relates to a tapered stent useful in tapered arteries including the carotid arteries.
  • Angioplasty and stenting have been widely applied to the coronary arteries as well as to the peripheral circulation. Recently the feasibility of stenting the carotid arteries, including the internal, external and common carotid arteries, has been shown. None of the existing stents is ideally suited for stenting the common carotid bifurcation or the proximal internal carotid artery. This is a significant problem since these are the most frequent sites for cerebrovascular atherosclerotic disease.
  • a substantially cylindrical stent is tapered from one end to the other.
  • the taper can be linear or non-linear, and the stent can be balloon-expandable or self-expanding.
  • the diameters at the ends of the stent and the degree of tapering can be varied to adapt to a wide range of artery sizes and geometries.
  • the stent tapers from the proximal to the distal end, it fits the smaller distal internal carotid artery as well as the larger carotid bulb without overdistending the distal artery or being undersized in the carotid bulb.
  • the stent of the invention is a self- expanding stent made from a shape-memory metallic alloy such as nitinol or superelastic nitinol.
  • a shape-memory metallic alloy such as nitinol or superelastic nitinol.
  • other metallic and non-metallic alloys, including stainless steel, can be used as well.
  • the stent can also be made with a small circular opening in the proximal portion of the stent allowing blood flow to the external carotid artery. Devices can also be passed through this opening into the external carotid for treatment purposes . Radiopaque markers placed around the circumference of this opening allow proper positioning of the opening at the origin of the external carotid artery.
  • the stent will be delivered inside a sheath which will be withdrawn, allowing for release and expansion of the stent.
  • the stent will preferably be sufficiently radiopaque to be easily visible under fluoroscopy; however, optimally radiopaque markers could also be placed at the ends of the stent to further aid placement .
  • Fig. 1 is a schematic view of a stent according to the invention within a delivery sheath
  • Figs. 2 and 3 are each an oblique view of an embodiment of the stent according to the invention.
  • Figs. 4 and 5 are each a cross-sectional schematic of an embodiment of the stent of the invention.
  • Fig. 6 is a partly cross-sectional view of a carotid artery with plaque
  • Fig. 7 is a partly cross-sectional view of the carotid artery in Fig. 4 with a stent according to the invention.
  • a stent 1 is positioned circumferentially around a delivery catheter 2 within a sheath 4.
  • Stent 1 is held in a constrained state by reusable fasteners 6 to the surface of delivery catheter 2.
  • Catheter 2, stent 1, and sheath 4 track along guidewire 8 until stent 1 reaches a desired location, at which time sheath 4 is moved proximally and then stent 1 is released from delivery catheter 2.
  • stent 1 An expanded stent 1 is shown in Figs. 2 and 3, where it can be seen that stent 1 tapers from proximal end 12 to distal end 14. The taper can be linear, gradual, or irregular, dependent upon the intended application.
  • stent 1 will have an opening 16 approximately 20 of the stent. Opening 18 may have one or more, preferably 3 or 4, equally spaced radiopaque markers to assist in positioning.
  • each of stent ends 12 and 14 may optimally have one or more, preferably 2 to 4, equally spaced radiopaque markers 20.
  • stent 1 will have a diameter of from about 9 to 11 mm at its proximal end and a diameter of from about 6 to 8 mm at its distal end, with a substantially linear taper. Opening 16 will be circular or oval, with an effective diameter of from about 2 to 4 mm. Additional, preferred embodiments of the tapered stent of the invention in expanded form can be seen in schematic form in Figs. 4 and 5.
  • a stent 22 comprises a substantially tubular or cylindrical proximal section 24, a linearly tapered intermediate section 26, and a substantially cylindrical distal section 28.
  • proximal section 24 has a length of approximately 10 mm and a diameter of approximately 10 mm
  • intermediate section 26 has a length of approximately 15 mm and a distal diameter of approximately 6 mm
  • distal section 28 has a diameter of approximately 6 mm and a length of approximately 15 mm.
  • a stent 30 comprises a proximal section 32 and a distal section 34, where proximal section 32 has an increasingly tapered, somewhat parabolic shape where the diameter changes from approximately 10 mm to approximately 6 mm and distal section 34 has a substantially constant diameter of approximately 6 mm.
  • proximal and distal sections 32 and 34 are from about 20 to 30 mm for section 32 and from about 10 to 20 mm for section 34, the total length of stent 30 being about 40 mm.
  • Fig. 6 represents a cross-sectional view of a carotid artery 42, wherein plaque 44 obstructs blood flow. As can be
  • a stent 46 has been positioned in the stent after a procedure such as angioplasty or atherectomy, where the tapered ratio of stent 46 facilitates comfortable placement.
  • the opening 48 facilitates blood flow to the external carotid artery.
  • the stent of the invention preferably comprises a self- expanding structure, although a balloon expandable structure could work as well.
  • Self-expanding and/or balloon expandable lattice-work structures are well known. See, for example, U.S. Patents Nos. 5,527,354, 5,545,211, 5,540,712, 5,545,210, 5,549,635, 5,653,727, 5,562,641, 5,562,725, 5,569,295, 5,571,166, 5,591,197, 5,591,230, 5,575,816, 5,575,818, 5,603,721, and 5,628,788, each of which is incorporated herein by reference, especially for the teachings of the structures and materials useful in self-expanding and balloon expandable stents.

Abstract

A stent for cardiovascular application wherein a substantially cylindrical tubular member tapers from its proximal end to its distal end.

Description

CAROTID STENT
FIELD OF THE INVENTION
This invention relates to stents useful in cardiovascular applications. More particularly, this invention relates to a tapered stent useful in tapered arteries including the carotid arteries.
BACKGROUND OF THE INVENTION
Angioplasty and stenting have been widely applied to the coronary arteries as well as to the peripheral circulation. Recently the feasibility of stenting the carotid arteries, including the internal, external and common carotid arteries, has been shown. None of the existing stents is ideally suited for stenting the common carotid bifurcation or the proximal internal carotid artery. This is a significant problem since these are the most frequent sites for cerebrovascular atherosclerotic disease.
Current stents, whether balloon-expandable or self- expanding, are straight tubes which have two major shortcomings when used in carotid applications. First, they do not fit the fairly rapid taper of the proximal internal carotid artery. And second, they tend to compromise the flow to the external carotid artery.
OBJECTS OF THE INVENTION It is an object of the invention to provide a novel, tapered stent .
It is also an object of the invention to provide a stent especially useful in carotid arteries.
It is a further object of the invention to provide a stent having a lateral opening to facilitate blood flow to the external carotid artery. These and other objects of the invention will become more apparent from the discussion below.
SUMMARY OF THE INVENTION According to the invention a substantially cylindrical stent is tapered from one end to the other. The taper can be linear or non-linear, and the stent can be balloon-expandable or self-expanding. The diameters at the ends of the stent and the degree of tapering can be varied to adapt to a wide range of artery sizes and geometries. When the stent tapers from the proximal to the distal end, it fits the smaller distal internal carotid artery as well as the larger carotid bulb without overdistending the distal artery or being undersized in the carotid bulb. Preferably the stent of the invention is a self- expanding stent made from a shape-memory metallic alloy such as nitinol or superelastic nitinol. However, other metallic and non-metallic alloys, including stainless steel, can be used as well. The stent can also be made with a small circular opening in the proximal portion of the stent allowing blood flow to the external carotid artery. Devices can also be passed through this opening into the external carotid for treatment purposes . Radiopaque markers placed around the circumference of this opening allow proper positioning of the opening at the origin of the external carotid artery.
The stent will be delivered inside a sheath which will be withdrawn, allowing for release and expansion of the stent. The stent will preferably be sufficiently radiopaque to be easily visible under fluoroscopy; however, optimally radiopaque markers could also be placed at the ends of the stent to further aid placement . BRIEF DESCRIPTION OF THE DRAWINGS
Fig. 1 is a schematic view of a stent according to the invention within a delivery sheath;
Figs. 2 and 3 are each an oblique view of an embodiment of the stent according to the invention;
Figs. 4 and 5 are each a cross-sectional schematic of an embodiment of the stent of the invention;
Fig. 6 is a partly cross-sectional view of a carotid artery with plaque; and Fig. 7 is a partly cross-sectional view of the carotid artery in Fig. 4 with a stent according to the invention.
DETAILED DESCRIPTION OF THE INVENTION
The invention can perhaps be better appreciated by referring to the drawings. In Fig. 1 a stent 1 is positioned circumferentially around a delivery catheter 2 within a sheath 4. Stent 1 is held in a constrained state by reusable fasteners 6 to the surface of delivery catheter 2. Catheter 2, stent 1, and sheath 4 track along guidewire 8 until stent 1 reaches a desired location, at which time sheath 4 is moved proximally and then stent 1 is released from delivery catheter 2.
Various delivery systems for self-expanding or balloon- expandable stents are known and would be applicable here. See, for example, U.S. Patents Nos . 4,886,062, 4,913,141, 5,507,768, 5,147,370, 5,534,007, 5,571,135, 5,632,760, 5,643,278, and 5,669,932, each of which is incorporated herein by reference, especially for the teaching of stent delivery systems. An expanded stent 1 is shown in Figs. 2 and 3, where it can be seen that stent 1 tapers from proximal end 12 to distal end 14. The taper can be linear, gradual, or irregular, dependent upon the intended application. Preferably stent 1 will have an opening 16 approximately 20 of the stent. Opening 18 may have one or more, preferably 3 or 4, equally spaced radiopaque markers to assist in positioning. Similarly, each of stent ends 12 and 14 may optimally have one or more, preferably 2 to 4, equally spaced radiopaque markers 20.
As mentioned earlier, the diameters of the ends 12,14 of the stent and the lengths of the stent will vary greatly. In a preferred embodiment for carotid application, it is envisioned that stent 1 will have a diameter of from about 9 to 11 mm at its proximal end and a diameter of from about 6 to 8 mm at its distal end, with a substantially linear taper. Opening 16 will be circular or oval, with an effective diameter of from about 2 to 4 mm. Additional, preferred embodiments of the tapered stent of the invention in expanded form can be seen in schematic form in Figs. 4 and 5. A stent 22 comprises a substantially tubular or cylindrical proximal section 24, a linearly tapered intermediate section 26, and a substantially cylindrical distal section 28. Here, proximal section 24 has a length of approximately 10 mm and a diameter of approximately 10 mm, intermediate section 26 has a length of approximately 15 mm and a distal diameter of approximately 6 mm, and distal section 28 has a diameter of approximately 6 mm and a length of approximately 15 mm. In Fig. 5 a stent 30 comprises a proximal section 32 and a distal section 34, where proximal section 32 has an increasingly tapered, somewhat parabolic shape where the diameter changes from approximately 10 mm to approximately 6 mm and distal section 34 has a substantially constant diameter of approximately 6 mm. The respective lengths of proximal and distal sections 32 and 34 are from about 20 to 30 mm for section 32 and from about 10 to 20 mm for section 34, the total length of stent 30 being about 40 mm. Fig. 6 represents a cross-sectional view of a carotid artery 42, wherein plaque 44 obstructs blood flow. As can be
-4- seen in Fig. 5, a stent 46 has been positioned in the stent after a procedure such as angioplasty or atherectomy, where the tapered ratio of stent 46 facilitates comfortable placement. The opening 48 facilitates blood flow to the external carotid artery.
The stent of the invention preferably comprises a self- expanding structure, although a balloon expandable structure could work as well. Self-expanding and/or balloon expandable lattice-work structures are well known. See, for example, U.S. Patents Nos. 5,527,354, 5,545,211, 5,540,712, 5,545,210, 5,549,635, 5,653,727, 5,562,641, 5,562,725, 5,569,295, 5,571,166, 5,591,197, 5,591,230, 5,575,816, 5,575,818, 5,603,721, and 5,628,788, each of which is incorporated herein by reference, especially for the teachings of the structures and materials useful in self-expanding and balloon expandable stents.
The preceding specific embodiments are illustrative of the practice of the invention. It is to be understood, however, that other expedients known to those skilled in the art or disclosed herein, may be employed without departing from the spirit of the invention or the scope of the appended claims .

Claims

I CLAIM :
I. A stent for cardiovascular application wherein a substantially cylindrical tubular member tapers from its proximal end to its distal end.
2. The stent of Claim 1, which has a lateral opening for blood flow.
3. The stent of Claim 2 , wherein the lateral opening is located approximately 20 to 40 % of the distance from the proximal end to the distal end.
4. The stent of Claim 1 which is self-expanding.
5. The stent of Claim 1, wherein the tubular member comprises a distal section that is substantially cylindrical, and intermediate section that is substantially linearly tapered, and a distal section that is substantially cylindrical.
6. The stent of Claim 5, wherein the diameter of the distal end is about 10 mm and the diameter of the proximal end of about 6 mm.
7. The stent of Claim 5, wherein the proximal section is about 10 mm in length, the intermediate section is about
15 mm in length, and the distal section is about 15 mm in length.
8. The stent of Claim 1, wherein the stent comprises a proximal section having an increasingly tapered shape and a distal section having a substantially cylindrical shape.
9. The stent of Claim 8, wherein the diameter of the proximal end is about 10 mm and the diameter of the distal end is about 6 mm.
10. The stent of claim 8, wherein the length of the proximal section is from about 20 to 30 mm and the length of the distal section is from about 10 to 20 mm.
II. A method of treating a carotid stenosis which comprises the steps of engaging plaque in a carotid artery to remove the plaque or to open a space within the plaque, advancing a guidewire into the carotid artery, advancing a delivery catheter comprising a stent of Claim 1 in a collapsed or constrained configuration over the guidewire to a point adjacent the stenosis, and releasing the stent from the delivery catheter.
12. The method of Claim 11, wherein the stent has a lateral opening and the lateral opening is positioned to facilitate blood flow to an external carotid artery.
13. A method of treating a carotid stenosis which comprises the steps of advancing a guidewire into a carotid artery, advancing a delivery catheter comprising a stent of claim in a collapsed or constrained configuration over the guidewire to a point adjacent the stenosis, and releasing the stent from the delivery catheter.
1 . The method of Claim 13 , wherein the stent has a lateral opening and the lateral opening is positioned to facilitate blood flow to an external carotid artery.
PCT/US1998/011448 1997-05-28 1998-05-28 Carotid stent WO1998053759A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU78131/98A AU7813198A (en) 1997-05-28 1998-05-28 Carotid stent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4799497P 1997-05-28 1997-05-28
US60/047,994 1997-05-28

Publications (1)

Publication Number Publication Date
WO1998053759A2 true WO1998053759A2 (en) 1998-12-03

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WO (1) WO1998053759A2 (en)

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000015146A1 (en) * 1998-09-10 2000-03-23 Percardia, Inc. Transmyocardial shunt for left ventricular revascularization
WO2000067673A1 (en) * 1999-05-11 2000-11-16 Jomed Gmbh Method and device for implanting vascular stents
WO2001006954A1 (en) 1999-07-22 2001-02-01 Advanced Cardiovascular Systems, Inc. Tapered self-expanding stent
US6253768B1 (en) 1999-08-04 2001-07-03 Percardia, Inc. Vascular graft bypass
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
WO2002013727A1 (en) * 2000-08-16 2002-02-21 Edwards Lifesciences Corporation Stent for implantation into the carotid artery formed by process using intraluminal mapping
WO2001045594A3 (en) * 1999-12-15 2002-11-14 Advanced Cardiovascular System Stent and stent delivery assembly and method of use
EP1267750A1 (en) * 2000-03-27 2003-01-02 Aga Medical Corporation Repositionable and recapturable vascular stent/graft
WO2003015666A2 (en) * 2001-08-15 2003-02-27 Edwards Lifesciences Corporation Virtual stent making process derived from endoluminal mapping
EP1669042A3 (en) * 1998-09-10 2006-06-28 Percardia, Inc. TMR shunt
WO2006138146A1 (en) * 2005-06-14 2006-12-28 Boston Scientific Limited Medical device system
WO2008118267A1 (en) * 2007-03-28 2008-10-02 Boston Scientific Limited Bifurcation stent and balloon assemblies
US8623070B2 (en) 2007-03-08 2014-01-07 Thomas O. Bales Tapered helical stent and method for manufacturing the stent
WO2017100977A1 (en) * 2015-12-14 2017-06-22 北京阿迈特医疗器械有限公司 Individualized polymer stent and manufacturing method therefor and use thereof
EP3240507A4 (en) * 2014-12-29 2018-12-05 Ocudyne LLC Apparatus and method for treating eye diseases
US10426642B2 (en) 2011-10-10 2019-10-01 National University Of Singapore Membrane for covering a peripheral surface of a stent
US10993805B2 (en) 2008-02-26 2021-05-04 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11065138B2 (en) 2016-05-13 2021-07-20 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
US11185405B2 (en) 2013-08-30 2021-11-30 Jenavalve Technology, Inc. Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
US11197754B2 (en) 2017-01-27 2021-12-14 Jenavalve Technology, Inc. Heart valve mimicry
US11337800B2 (en) 2015-05-01 2022-05-24 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
US11357624B2 (en) 2007-04-13 2022-06-14 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US11517431B2 (en) 2005-01-20 2022-12-06 Jenavalve Technology, Inc. Catheter system for implantation of prosthetic heart valves
US11564794B2 (en) 2008-02-26 2023-01-31 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11589981B2 (en) 2010-05-25 2023-02-28 Jenavalve Technology, Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
WO2000015146A1 (en) * 1998-09-10 2000-03-23 Percardia, Inc. Transmyocardial shunt for left ventricular revascularization
EP1669042A3 (en) * 1998-09-10 2006-06-28 Percardia, Inc. TMR shunt
WO2000067673A1 (en) * 1999-05-11 2000-11-16 Jomed Gmbh Method and device for implanting vascular stents
WO2001006954A1 (en) 1999-07-22 2001-02-01 Advanced Cardiovascular Systems, Inc. Tapered self-expanding stent
US6569193B1 (en) 1999-07-22 2003-05-27 Advanced Cardiovascular Systems, Inc. Tapered self-expanding stent
US6253768B1 (en) 1999-08-04 2001-07-03 Percardia, Inc. Vascular graft bypass
WO2001045594A3 (en) * 1999-12-15 2002-11-14 Advanced Cardiovascular System Stent and stent delivery assembly and method of use
EP1267750A4 (en) * 2000-03-27 2007-03-14 Aga Medical Corp Repositionable and recapturable vascular stent/graft
EP1267750A1 (en) * 2000-03-27 2003-01-02 Aga Medical Corporation Repositionable and recapturable vascular stent/graft
EP1994911A1 (en) * 2000-03-27 2008-11-26 AGA Medical Corporation Repositionable and recapturable vascular stent/graft
WO2002013727A1 (en) * 2000-08-16 2002-02-21 Edwards Lifesciences Corporation Stent for implantation into the carotid artery formed by process using intraluminal mapping
WO2003015666A2 (en) * 2001-08-15 2003-02-27 Edwards Lifesciences Corporation Virtual stent making process derived from endoluminal mapping
WO2003015666A3 (en) * 2001-08-15 2004-03-18 Edwards Lifesciences Corp Virtual stent making process derived from endoluminal mapping
US11517431B2 (en) 2005-01-20 2022-12-06 Jenavalve Technology, Inc. Catheter system for implantation of prosthetic heart valves
WO2006138146A1 (en) * 2005-06-14 2006-12-28 Boston Scientific Limited Medical device system
US8623070B2 (en) 2007-03-08 2014-01-07 Thomas O. Bales Tapered helical stent and method for manufacturing the stent
WO2008118267A1 (en) * 2007-03-28 2008-10-02 Boston Scientific Limited Bifurcation stent and balloon assemblies
US11357624B2 (en) 2007-04-13 2022-06-14 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US10993805B2 (en) 2008-02-26 2021-05-04 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11154398B2 (en) 2008-02-26 2021-10-26 JenaValve Technology. Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11564794B2 (en) 2008-02-26 2023-01-31 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11589981B2 (en) 2010-05-25 2023-02-28 Jenavalve Technology, Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US10426642B2 (en) 2011-10-10 2019-10-01 National University Of Singapore Membrane for covering a peripheral surface of a stent
US11185405B2 (en) 2013-08-30 2021-11-30 Jenavalve Technology, Inc. Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
EP3240507A4 (en) * 2014-12-29 2018-12-05 Ocudyne LLC Apparatus and method for treating eye diseases
US11337800B2 (en) 2015-05-01 2022-05-24 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
WO2017100977A1 (en) * 2015-12-14 2017-06-22 北京阿迈特医疗器械有限公司 Individualized polymer stent and manufacturing method therefor and use thereof
US11065138B2 (en) 2016-05-13 2021-07-20 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
US11197754B2 (en) 2017-01-27 2021-12-14 Jenavalve Technology, Inc. Heart valve mimicry

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Publication number Publication date
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