WO1998051356A1 - Receptacle for preparing medicines and injection kit containing same and filtering adapter - Google Patents

Receptacle for preparing medicines and injection kit containing same and filtering adapter Download PDF

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Publication number
WO1998051356A1
WO1998051356A1 PCT/FR1998/000947 FR9800947W WO9851356A1 WO 1998051356 A1 WO1998051356 A1 WO 1998051356A1 FR 9800947 W FR9800947 W FR 9800947W WO 9851356 A1 WO9851356 A1 WO 9851356A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
syringe
tip
container according
needle
Prior art date
Application number
PCT/FR1998/000947
Other languages
French (fr)
Inventor
Elliot Imbert
Original Assignee
Elliot Imbert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9705782A external-priority patent/FR2762995B1/en
Priority claimed from FR9715746A external-priority patent/FR2772279B1/en
Application filed by Elliot Imbert filed Critical Elliot Imbert
Priority to CA002290667A priority Critical patent/CA2290667A1/en
Priority to AU76629/98A priority patent/AU7662998A/en
Priority to EP98924423A priority patent/EP0981382A1/en
Publication of WO1998051356A1 publication Critical patent/WO1998051356A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices

Definitions

  • the invention relates to the field of the preparation of active products and of drugs with a view to their injection and, more specifically, when this preparation requires a syringe, an auxiliary preparation container, sterile water in the container or in a flask.
  • Water and other items are sterile and are for single use only.
  • the preparation container may have a rim on which a water protection cover can be welded in the event that the water
  • sterile is placed in the container.
  • This set and other elements such as a post-injection tampon, an alcoholic compress, citric or ascorbic acid, form a kit placed in a box available in pharmacies or in specialized establishments.
  • the preparation may only be soluble in water when hot, and therefore
  • the container is metallic to support the flame.
  • the container is formed by stamping a light metal, for example an aluminum foil.
  • a large part of the rim thereof is extended in the form of a tab or tongue
  • the invention proposes another solution, without increasing the cost of the kit or complicating the implementation of the manufacture of the container.
  • This solution is based on the use of an element made of plastic material present in the kit, non-conductive of heat and whose interior is sterile. This element adapts to the container, shaped to provide a secure connection, to serve as a gripping tab with bare hands without fear of getting burned.
  • the subject of the invention is a container for preparing medicaments and active products for their administration by injection, forming a crucible bounded by an edge.
  • the border has a shaped projection to make a connection between the container and a syringe tip having a sterile bore, so that the asepsis of the crucible and its thermal insulation are preserved by using this tip as a gripping tab and holding the container when heating the crucible in heat-conductive metal, this heating being necessary for the solubilization of the active product.
  • the syringe tip can be the needle tip or the syringe plunger head tip.
  • the invention also relates to a kit for the administration of active products and of medicaments containing a container of the special form indicated above, suitable for its connection with the tip of the syringe contained in this kit.
  • the syringe is pre-filled with sterile and injectable water.
  • the product to be injected is purified by an impurity filter contained in the kit. Such a purification limiting the number and size of particles aspirated into the syringe, bacterial, fungal and parasitic elements are not aspirated.
  • This filter is mounted, for example by welding, in the tip of the syringe needle to allow direct use of the filter during the aspiration of the drug or of the active product in the body of the syringe, without having to detach the tip of the syringe needle for this filtration operation.
  • the tip can be covered with a sterile cap to protect the filter.
  • Such an arrangement is particularly suitable for crimped needles, but can also be used when the needle is extractable.
  • the tip of the piston head is used to serve as a means of gripping the metal crucible.
  • FIG. 5 a view of the syringe provided with a filter needle tip according to the invention.
  • the plastic tip of the syringe and the container for mixing the product to be administered make it possible, by their combination produced by different types of connection, to solve the problem linked to the thermal conductivity of the material constituting the container. mixing or additional costs relating to the use of poorly conductive material.
  • identical reference signs designate the same objects.
  • the preparation container has a rim, but the invention also relates to containers without rim, that is to say the edge forming the upper limit of the crucible does not have a curved portion forming a ring of peripheral material. According to a first exemplary embodiment illustrated in FIG.
  • the container 1 comprises a crucible 1a bounded by a rim 2, on which a cover 3 is welded, and an edge projection in the form of a protuberance 4.
  • This protuberance 4 can be obtained during stamping when this border is calibrated by cutting. The cutting is then carried out except for a portion corresponding to the protuberance.
  • the border can be entirely eliminated, except the portion corresponding to the projection, when it comes to obtaining a container without rim.
  • This protuberance is in the form of a substantially rectangular surface of predetermined width so that it can be inserted into the internal bore A of the tip 5 of the needle of the syringe (not shown) or the tip of piston.
  • this width is, respectively, equal to or slightly greater than 4 mm or 10 mm, depending on whether the tip is that of the syringe or of the plunger. So as to be inserted easily, but in force, in this bore, the insertion is obtained by ovalization of the bore which results from manual pressure exerted on the plastic material of which the end piece is made.
  • the length of the protrusion is to be appreciated by a person skilled in the art as a function in particular of the density of the metal used for the container, so as not to risk the loss of the container by stalling due to the mass to be supported.
  • the protrusion 4 can be oriented relative to the upper plane of the container 1, pressing on the surface of the rim 2, at an angle varying between approximately plus or minus 30 degrees. The angle is limited so as not to risk a disconnection between the nozzle and the container.
  • the projection is in the form of a perforated tab 4 ′, having a circular hole 6, the diameter of which is equal to the external diameter of the end piece 5, near the flange 7 of this tip.
  • Such a collar is usually formed at the end of the tip covering the end of the needle of the syringe, the bore A of the tip thus forming a blind hole intended to protect the syringe, in particular its end.
  • the tab 4 ′ can be oriented either substantially in a plane perpendicular to the upper plane of the container 1, or in this plane as illustrated in FIG. 3. In this case, the end piece 5 is oriented along an axis perpendicular to the upper plane of the container 1.
  • the projection is formed by a substantially cylindrical surface 4 ".
  • the projection is formed initially, in this example, by a flat surface of sufficient size for the edges 4a and 4b of this surface, once folded towards each other, form a substantially cylindrical surface, the edges 4a and 4b facing each other until defining a slot F, parallel to the axis of revolution X'X of this surface and of minimal or zero width.
  • the diameter of this cylindrical surface corresponds to the external diameter of the tip 5 of the syringe needle, so that, when the tip 5 is inserted into the space defined by this surface, this tip is held firmly by the 4 "cylindrical surface.
  • the flange 7 is disposed in abutment against the circular edge of the 4" cylindrical surface disposed on the side of the container 1. It is within the capacity of those skilled in the art to adapt the known stamping techniques of so as to obtain the optimal advancement dimensions to obtain a good connection between the container and the nozzle. In particular, the formation of holes in these protuberances, or the folding of these can be obtained using known techniques. In FIG.
  • the nozzle 9 comprises a filter 12 for filtering out impurities and a cap 13 the interior of which is sterilized to protect the nozzle which it covers.
  • This tip is particularly suitable in the case of a syringe with a crimped needle 10 for filtering the active product dissolved and taken from the container 1.
  • the filter is a nylon® membrane in the embodiment, with a porosity of 5 to 20 ⁇ m for good retention of impurities. Such a tip can also be used with syringes with an uncapped needle.
  • the solubilization of the active product is obtained by using sterile water mixed with the active product in the crucible, using the piston head 8b which is sterile, to stir the assembly aseptically for its dissolution. Then the assembly is heated under the crucible, after having placed the end piece 11 around the tongue 4 of the container, using it in the manner of a handle to prevent the user from being burned.
  • the solubilized active product is also withdrawn, in this embodiment, in the syringe through the filter tip, once the cap from the tip of the needle 10 has been removed.
  • the surface of the filter 12 (FIG. 5) facing the needle is advantageously inclined in order to closely match the bevelled end surface of the needle 10.
  • the invention also relates to a kit for administering products and drugs containing in particular a mixing container, as described above, a conventional syringe equipped with needle and piston tips, an external water filtration filter. sterile.
  • This water can be placed in a separate bottle, in the container or in the pre-filled syringe.
  • the entire container and the filter placed in the container can advantageously be placed in a flexible sterilizable packaging.
  • This set is intended for single use, for the prevention of infectious contaminations, and for the elimination of impurities.
  • the invention is not limited to the embodiments described and shown.
  • the filter can be of the filtering or absorbing type.
  • at least one filtering tip according to the invention can be placed in the kit, then adapted on the needle in place of the conventional tip. during the filtration operation.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The invention concerns the preparation of active products and medicines to be injected from a kit, when such preparation requires in particular a disposable syringe and auxiliary preparation receptacle. The receptacle is made in light metal, such as aluminium, highly heat conducting thereby making the receptacle very difficult to be held with bare hands when it is heated on a flame for preparing the mixture to be injected. The invention enables the use of a plastic element present in the kit as a strip for grasping the receptacle with bare hands, shaped to provide it with a safe connection, and to suck in the active product while observing the aseptic conditions required for the operation. The preparation receptacle has the shape of a crucible delimited by a rim (2) with a protruding part (4) providing a link between the receptacle (1) and a syringe adapter (5). A sleeve (9) of the syringe (8) needle (10) incorporates a filter (12) to purify the suction.

Description

RECIPIENT DE PREPARATION DE MEDICAMENTS ET KIT D'INJECTION CONTENANT UN TEL RECIPIENT ET UNE SERINGUE A EMBOUT FILTRANTDRUG PREPARATION CONTAINER AND INJECTION KIT CONTAINING SUCH A CONTAINER AND A SYRINGE WITH FILTERING NOZZLE
L'invention se rapporte au domaine de la préparation de produits actifs et de médicaments en vue de leur injection et, plus précisément, lorsque cette préparation nécessite une seringue, un récipient auxiliaire de 5 préparation, de l'eau stérile dans le récipient ou dans un flacon. L'eau et les autres éléments sont stériles et sont à usage unique. L'utilisation d'un filtre lui-même stérile et à usage unique, permet alors de purifier le produit à injecter. Le récipient de préparation peut comporter un rebord sur lequel peut être soudé un opercule de protection de l'eau dans le cas où l'eauThe invention relates to the field of the preparation of active products and of drugs with a view to their injection and, more specifically, when this preparation requires a syringe, an auxiliary preparation container, sterile water in the container or in a flask. Water and other items are sterile and are for single use only. The use of a filter itself sterile and disposable, then allows to purify the product to be injected. The preparation container may have a rim on which a water protection cover can be welded in the event that the water
10 stérile est disposée dans le récipient. Cet ensemble et d'autres éléments, comme un tampon de post-injection, une compresse alcoolisée, de l'acide citrique ou ascorbique, forment un kit disposé dans un boîtier disponible en pharmacie ou dans des établissements spécialisés.10 sterile is placed in the container. This set and other elements, such as a post-injection tampon, an alcoholic compress, citric or ascorbic acid, form a kit placed in a box available in pharmacies or in specialized establishments.
La préparation peut n'être soluble dans l'eau qu'à chaud et, de ceThe preparation may only be soluble in water when hot, and therefore
15 fait, le récipient est métallique pour supporter la flamme. Pour des questions de coût et de facilité de réalisation, le récipient est formé par emboutissage d'un métal léger, par exemple d'une feuille d'aluminium. Afin d'obtenir une bonne tenue manuelle du récipient, une partie importante du rebord de celui-ci est prolongé sous la forme d'une patte ou langue15 done, the container is metallic to support the flame. For reasons of cost and ease of production, the container is formed by stamping a light metal, for example an aluminum foil. In order to obtain good manual holding of the container, a large part of the rim thereof is extended in the form of a tab or tongue
20 sensiblement triangulaire. Or, avec ce type de métal fortement conducteur de la chaleur, la préhension à main nue est difficilement supportable et provoque des brûlures lorsque, lors de la préparation du mélange à injecter, le récipient est chauffé à la flamme.20 substantially triangular. However, with this type of metal which is highly conductive of heat, gripping with bare hands is difficult to bear and causes burns when, during the preparation of the mixture to be injected, the container is heated with a flame.
Pour résoudre ce problème, diverses solutions ont déjà étéTo solve this problem, various solutions have already been
25 proposées. Par exemple, la demande de certificat d'utilité français, publiée sous le numéro 2722412, préconise de revêtir la languette d'un matériau mauvais conducteur de la chaleur, ou bien d'entourer le récipient d'un support en carton sur lequel l'opercule est également fixé. Ces solutions entraînent la mise en place de moyens supplémentaires qui augmentent le25 proposed. For example, the application for a French utility certificate, published under the number 2722412, recommends coating the tongue with a material that is poorly conductive of heat, or else surrounding the container with a cardboard support on which the cover is also attached. These solutions involve the installation of additional means which increase the
30 coût du kit en compliquant la fabrication de la cuillère sans garantir une bonne réduction des risques de brûlure. Par ailleurs, même si le récipient est en métal pas ou peu conducteur de la chaleur, comme de l'acier inoxydable, la quantité de métal nécessaire pour constituer la langue de préhension entraîne surcoût et encombrement. Afin de résoudre le problème évoqué, tout en préservant l'asepsie du récipient lors de la préparation du produit actif, l'invention propose une autre solution, sans augmenter le coût du kit ni compliquer la mise en oeuvre de la fabrication du récipient. Cette solution est basée sur l'utilisation d'un élément en matériau plastique présent dans le kit, non conducteur de la chaleur et dont l'intérieur est stérile. Cet élément s'adapte au récipient, conformé afin de lui offrir une connexion sûre, pour servir de languette de préhension à mains nues sans craindre de se brûler.30 cost of the kit by complicating the manufacture of the spoon without guaranteeing a good reduction in the risk of burns. Furthermore, even if the container is made of metal which is not or only slightly conductive of heat, such as stainless steel, the quantity of metal necessary to constitute the gripping tongue entails additional cost and bulk. In order to solve the problem mentioned, while preserving the asepsis of the container during the preparation of the active product, the invention proposes another solution, without increasing the cost of the kit or complicating the implementation of the manufacture of the container. This solution is based on the use of an element made of plastic material present in the kit, non-conductive of heat and whose interior is sterile. This element adapts to the container, shaped to provide a secure connection, to serve as a gripping tab with bare hands without fear of getting burned.
Plus précisément, l'invention a pour objet un récipient de préparation de médicaments et de produits actifs en vue de leur administration par injection, formant un creuset limité par une bordure. La bordure présente une avancée conformée pour réaliser une connexion entre le récipient et un embout de seringue présentant un alésage stérile, de sorte que l'asepsie du creuset et son isolation thermique soient conservées par utilisation de cet embout comme languette de préhension et de maintien du récipient lors du chauffage du creuset en métal conducteur de la chaleur, ce chauffage étant nécessaire à la solubilisation du produit actif.More specifically, the subject of the invention is a container for preparing medicaments and active products for their administration by injection, forming a crucible bounded by an edge. The border has a shaped projection to make a connection between the container and a syringe tip having a sterile bore, so that the asepsis of the crucible and its thermal insulation are preserved by using this tip as a gripping tab and holding the container when heating the crucible in heat-conductive metal, this heating being necessary for the solubilization of the active product.
L'embout de seringue peut être l'embout de l'aiguille ou l'embout de la tête de piston de la seringue. L'invention concerne également un kit pour l'administration de produits actifs et de médicaments contenant un récipient de la forme spéciale indiquée ci-dessus, adaptée pour sa connexion avec l'embout de la seringue contenue dans ce kit. Avantageusement, la seringue est préremplie d'eau stérile et injectable. Dans le but d'améliorer l'asepsie, une purification du produit à injecter est assurée par un filtre d'impureté contenu dans le kit. Une telle purification limitant le nombre et la taille des particules aspirées dans la seringue, des éléments bactériens, fongiques et parasitaires ne sont pas aspirés. Ce filtre est monté, par exemple par soudage, dans l'embout de l'aiguille de la seringue pour permettre une utilisation directe du filtre lors de l'aspiration du médicament ou du produit actif dans le corps de la seringue, sans avoir à détacher l'embout de l'aiguille de la seringue pour cette opération de filtration. L'embout peut être recouvert d'un capuchon stérile pour protéger le filtre. Une telle disposition est particulièrement adaptée à des aiguilles serties, mais peut également être utilisée lorsque l'aiguille est extractible. Dans ce mode réalisation, l'embout de la tête de piston est utilisé pour servir de moyen de préhension du creuset métallique.The syringe tip can be the needle tip or the syringe plunger head tip. The invention also relates to a kit for the administration of active products and of medicaments containing a container of the special form indicated above, suitable for its connection with the tip of the syringe contained in this kit. Advantageously, the syringe is pre-filled with sterile and injectable water. In order to improve asepsis, the product to be injected is purified by an impurity filter contained in the kit. Such a purification limiting the number and size of particles aspirated into the syringe, bacterial, fungal and parasitic elements are not aspirated. This filter is mounted, for example by welding, in the tip of the syringe needle to allow direct use of the filter during the aspiration of the drug or of the active product in the body of the syringe, without having to detach the tip of the syringe needle for this filtration operation. The tip can be covered with a sterile cap to protect the filter. Such an arrangement is particularly suitable for crimped needles, but can also be used when the needle is extractable. In this embodiment, the tip of the piston head is used to serve as a means of gripping the metal crucible.
D'autres caractéristiques et avantages de l'invention apparaîtront à la lecture détaillée qui suit en référence aux figures annexées qui représentent, respectivement : - la figure 1 , une vue perspective d'un premier exemple de réalisation de récipient selon l'invention pour opérer la connexion entre un récipient et un embout de seringue;Other characteristics and advantages of the invention will appear on reading the following details with reference to the appended figures which represent, respectively: - Figure 1, a perspective view of a first embodiment of a container according to the invention for operating the connection between a container and a syringe tip;
- la figure 2, un deuxième exemple d'un tel récipient ;- Figure 2, a second example of such a container;
- la figure 3, un troisième exemple de récipient; - la figure 4, un quatrième exemple de ce même récipient;- Figure 3, a third example of container; - Figure 4, a fourth example of the same container;
- la figure 5, une vue de la seringue munie d'un embout d'aiguille à filtre selon l'invention.- Figure 5, a view of the syringe provided with a filter needle tip according to the invention.
Selon l'invention, l'embout en matière plastique de la seringue et le récipient de mélange du produit à administrer permettent, par leur combinaison réalisée par différents types de connexion, à résoudre le problème lié à la conductivité thermique du matériau constituant le récipient de mélange ou des surcoûts relatifs à l'utilisation de matériau peu conducteurs. Dans les différents exemples de réalisation illustrés, des signes de référence identiques désignent les mêmes objets. Dans ces exemples, le récipient de préparation comporte un rebord, mais l'invention concerne aussi bien des récipients sans rebord, c'est-à-dire dont la bordure formant la limite supérieure du creuset ne présente pas de portion recourbée formant une couronne de matière périphérique. Selon un premier exemple de réalisation illustré à la figure 1 , le récipient 1 comporte un creuset 1a limité par un rebord 2, sur lequel est soudé un opercule 3, et une avancée de bordure sous la forme d'une protubérance 4. Cette protubérance 4 peut être obtenue lors de l'emboutissage lorsqu'il est procédé à la calibration de cette bordure par découpage. Le découpage est alors réalisé hormis une portion correspondant à la protubérance. La bordure peut être entièrement éliminée, sauf la portion correspondant à l'avancée, lorsqu'il s'agit d'obtenir un récipient sans rebord.According to the invention, the plastic tip of the syringe and the container for mixing the product to be administered make it possible, by their combination produced by different types of connection, to solve the problem linked to the thermal conductivity of the material constituting the container. mixing or additional costs relating to the use of poorly conductive material. In the various exemplary embodiments illustrated, identical reference signs designate the same objects. In these examples, the preparation container has a rim, but the invention also relates to containers without rim, that is to say the edge forming the upper limit of the crucible does not have a curved portion forming a ring of peripheral material. According to a first exemplary embodiment illustrated in FIG. 1, the container 1 comprises a crucible 1a bounded by a rim 2, on which a cover 3 is welded, and an edge projection in the form of a protuberance 4. This protuberance 4 can be obtained during stamping when this border is calibrated by cutting. The cutting is then carried out except for a portion corresponding to the protuberance. The border can be entirely eliminated, except the portion corresponding to the projection, when it comes to obtaining a container without rim.
Cette protubérance se présente sous la forme d'une surface sensiblement rectangulaire de largeur prédéterminée de manière à pouvoir être insérée dans l'alésage interne A de l'embout 5 de l'aiguille de la seringue (non représentée) ou de l'embout de piston. En pratique, cette largeur est, respectivement, égale ou légèrement supérieure à 4 mm ou à 10 mm , selon que l'embout est celui de la seringue ou du piston. De manière à être insérée facilement, mais en force, dans cet alésage, l'insertion est obtenue par ovalisation de l'alésage qui résulte d'une pression manuelle exercée sur le matériau plastique dont est constitué l'embout. La longueur de la protubérance est à apprécier par l'homme du métier en fonction notamment de la densité du métal utilisé pour le récipient, afin de ne pas risquer la perte du récipient par décrochage du fait de la masse à supporter.This protuberance is in the form of a substantially rectangular surface of predetermined width so that it can be inserted into the internal bore A of the tip 5 of the needle of the syringe (not shown) or the tip of piston. In practice, this width is, respectively, equal to or slightly greater than 4 mm or 10 mm, depending on whether the tip is that of the syringe or of the plunger. So as to be inserted easily, but in force, in this bore, the insertion is obtained by ovalization of the bore which results from manual pressure exerted on the plastic material of which the end piece is made. The length of the protrusion is to be appreciated by a person skilled in the art as a function in particular of the density of the metal used for the container, so as not to risk the loss of the container by stalling due to the mass to be supported.
La protubérance 4 peut être orientée par rapport au plan supérieur du récipient 1 , s'appuyant sur la surface du rebord 2, selon un angle variant entre environ plus ou moins 30 degrés. L'angle est limité de manière à ne pas risquer une déconnexion entre l'embout et le récipient. Dans l'exemple illustré sur la figure 2, l'avancée se présente sous la forme d'une patte trouée 4', présentant un trou circulaire 6, dont le diamètre est égal au diamètre externe de l'embout 5, près de la collerette 7 de cet embout. Une telle collerette est habituellement formée à l'extrémité de l'embout recouvrant l'extrémité de l'aiguille de la seringue, l'alésage A de l'embout formant ainsi un trou borgne destiné à protéger la seringue, en particulier son extrémité. La patte 4' peut être orientée soit sensiblement dans un plan perpendiculaire au plan supérieur du récipient 1 , ou dans ce plan comme illustré à la figure 3. Dans ce cas, l'embout 5 se trouve orienté selon un axe perpendiculaire au plan supérieur du récipient 1.The protrusion 4 can be oriented relative to the upper plane of the container 1, pressing on the surface of the rim 2, at an angle varying between approximately plus or minus 30 degrees. The angle is limited so as not to risk a disconnection between the nozzle and the container. In the example illustrated in FIG. 2, the projection is in the form of a perforated tab 4 ′, having a circular hole 6, the diameter of which is equal to the external diameter of the end piece 5, near the flange 7 of this tip. Such a collar is usually formed at the end of the tip covering the end of the needle of the syringe, the bore A of the tip thus forming a blind hole intended to protect the syringe, in particular its end. The tab 4 ′ can be oriented either substantially in a plane perpendicular to the upper plane of the container 1, or in this plane as illustrated in FIG. 3. In this case, the end piece 5 is oriented along an axis perpendicular to the upper plane of the container 1.
Selon un autre exemple de réalisation, tel que représenté à la figure 4, l'avancée est formée par une surface sensiblement cylindrique 4". L'avancée est formée initialement, dans cet exemple, par une surface plane de dimension suffisante pour que les bords 4a et 4b de cette surface, une fois rabattus l'un vers l'autre, forment une surface sensiblement cylindrique, les bords 4a et 4b se faisant face jusqu'à définir une fente F, parallèle à l'axe de révolution X'X de cette surface et de largeur minime ou nulle.According to another exemplary embodiment, as shown in FIG. 4, the projection is formed by a substantially cylindrical surface 4 ". The projection is formed initially, in this example, by a flat surface of sufficient size for the edges 4a and 4b of this surface, once folded towards each other, form a substantially cylindrical surface, the edges 4a and 4b facing each other until defining a slot F, parallel to the axis of revolution X'X of this surface and of minimal or zero width.
Le diamètre de cette surface cylindrique correspond au diamètre externe de l'embout 5 de l'aiguille de la seringue, de sorte que, lorsque l'embout 5 est inséré dans l'espace défini par cette surface, cet embout est maintenu fermement par la surface cylindrique 4". La collerette 7 est disposée en butée contre le bord circulaire de la surface cylindrique 4" disposé du côté du récipient 1. II est à la portée de l'homme du métier d'adapter les techniques connues d'emboutissage de manière à obtenir les dimensions d'avancée optimale pour obtenir une bonne connexion entre le récipient et l'embout. En particulier, la formation de trous dans ces protubérances, ou le pliage de celles-ci peuvent être obtenus à l'aide de techniques connues. Sur la figure 5, la seringue 8, équipée de son piston 8a, de son embout 9 de protection d'aiguille 10 et de son embout 11 de protection de tête de piston 8b, est représentée de manière plus détaillée. L'embout 9 comporte un filtre 12 pour filtrer les impuretés et un capuchon 13 dont l'intérieur est stérilisé pour protéger l'embout qu'il recouvre. Cet embout est particulièrement adapté dans le cas de seringue à aiguille sertie 10 pour filtrer le produit actif solubilisé et prélevé dans le récipient 1. Le filtre est une membrane en Nylon® dans l'exemple de réalisation, avec une porosité de 5 à 20 μm pour une bonne rétention des impuretés. Un tel embout peut également être utilisé avec des seringues à aiguille non sertie.The diameter of this cylindrical surface corresponds to the external diameter of the tip 5 of the syringe needle, so that, when the tip 5 is inserted into the space defined by this surface, this tip is held firmly by the 4 "cylindrical surface. The flange 7 is disposed in abutment against the circular edge of the 4" cylindrical surface disposed on the side of the container 1. It is within the capacity of those skilled in the art to adapt the known stamping techniques of so as to obtain the optimal advancement dimensions to obtain a good connection between the container and the nozzle. In particular, the formation of holes in these protuberances, or the folding of these can be obtained using known techniques. In FIG. 5, the syringe 8, fitted with its piston 8a, its tip 9 for protecting the needle 10 and its tip 11 for protecting the piston head 8b, is shown in more detail. The nozzle 9 comprises a filter 12 for filtering out impurities and a cap 13 the interior of which is sterilized to protect the nozzle which it covers. This tip is particularly suitable in the case of a syringe with a crimped needle 10 for filtering the active product dissolved and taken from the container 1. The filter is a nylon® membrane in the embodiment, with a porosity of 5 to 20 μm for good retention of impurities. Such a tip can also be used with syringes with an uncapped needle.
La solubilisation du produit actif est obtenue en utilisant l'eau stérile mélangée au produit actif dans le creuset, en s'aidant de la tête de piston 8b qui est stérile, pour remuer l'ensemble de façon aseptique en vue de sa dissolution. Puis l'ensemble est chauffé sous le creuset, après avoir disposé l'embout 11 autour de la languette 4 du récipient, en l'utilisant à la manière d'un manche pour éviter que l'utilisateur ne se brûle. Le produit actif solubilisé est également prélevé, dans cet exemple de réalisation, dans la seringue à travers l'embout filtrant, une fois retiré le capuchon de l'embout de l'aiguille 10.The solubilization of the active product is obtained by using sterile water mixed with the active product in the crucible, using the piston head 8b which is sterile, to stir the assembly aseptically for its dissolution. Then the assembly is heated under the crucible, after having placed the end piece 11 around the tongue 4 of the container, using it in the manner of a handle to prevent the user from being burned. The solubilized active product is also withdrawn, in this embodiment, in the syringe through the filter tip, once the cap from the tip of the needle 10 has been removed.
Afin de perdre le moins de produit possible, la surface du filtre 12 (figure 5) en regard de l'aiguille est avantageusement inclinée afin d'épouser au plus près la surface d'extrémité biseautée de l'aiguille 10.In order to lose as little product as possible, the surface of the filter 12 (FIG. 5) facing the needle is advantageously inclined in order to closely match the bevelled end surface of the needle 10.
L'invention concerne également un kit d'administration de produits et de médicaments contenant notamment un récipient de mélange, tel que décrit précédemment, une seringue classique équipée d'embouts d'aiguille et de piston, un filtre de filtration externe de l'eau stérile. Cette eau peut être disposée dans un flacon séparé, dans le récipient ou dans la seringue préremplie. L'ensemble du récipient et du filtre posé dans le récipient peut être avantageusement disposé dans un emballage souple stérilisable. Cet ensemble est destiné à un usage unique, à la prévention des contaminations infectieuses, et à l'élimination des impuretés.. L'invention n'est pas limitée aux exemples de réalisation décrits et représentés. Par exemple, il est possible de prévoir plusieurs avancées de formes différentes ou identiques, par exemple telles que décrites ci-dessus, le long de la bordure d'un même récipient, de manière à pouvoir optimiser la connexion entre l'une de ces avancées et tout type de dimension d'embout de seringue ou d'autre élément adaptable utilisé dans le kit de préparation et d'injection.The invention also relates to a kit for administering products and drugs containing in particular a mixing container, as described above, a conventional syringe equipped with needle and piston tips, an external water filtration filter. sterile. This water can be placed in a separate bottle, in the container or in the pre-filled syringe. The entire container and the filter placed in the container can advantageously be placed in a flexible sterilizable packaging. This set is intended for single use, for the prevention of infectious contaminations, and for the elimination of impurities. The invention is not limited to the embodiments described and shown. For example, it is possible to provide several projections of different or identical shapes, for example as described above, along the edge of the same container, so as to be able to optimize the connection between one of these projections and any type of size of syringe tip or other adaptable element used in the preparation and injection kit.
Par ailleurs, le filtre peut être de type filtrant ou absorbant. De plus, dans le cas où la seringue est équipée d'un embout d'aiguille classique, au moins un embout filtrant selon l'invention peut être disposé dans le kit , puis adapté sur l'aiguille à la place de l'embout classique lors de l'opération de filtration. Furthermore, the filter can be of the filtering or absorbing type. In addition, in the case where the syringe is equipped with a conventional needle tip, at least one filtering tip according to the invention can be placed in the kit, then adapted on the needle in place of the conventional tip. during the filtration operation.

Claims

REVENDICATIONS
1.- Récipient de préparation de médicaments et de produits actifs en vue de leur administration par injection, formant un creuset limité par une bordure, caractérisé en ce que la bordure (2) présente une avancée (4,4',4") conformée pour réaliser une connexion entre le récipient (1 ) et un embout de seringue présentant un alésage stérile (5), de sorte que l'asepsie du creuset et son isolation thermique soient conservées par utilisation de cet embout comme languette de préhension et de maintien du récipient (1 ) lors du chauffage du creuset en métal conducteur de la chaleur, ce chauffage étant nécessaire à la solubilisation du produit actif.1.- container for the preparation of drugs and active products for their administration by injection, forming a crucible limited by a border, characterized in that the border (2) has a shaped projection (4,4 ', 4 ") to make a connection between the container (1) and a syringe tip having a sterile bore (5), so that the asepsis of the crucible and its thermal insulation are preserved by using this tip as a gripping tab and holding the container (1) during heating of the crucible made of heat-conducting metal, this heating being necessary for the solubilization of the active product.
2.- Récipient selon la revendication 1 , caractérisé en ce que l'avancée est une protubérance (4) qui se présente sous la forme d'une surface sensiblement rectangulaire de largeur correspondant au diamètre de l'alésage interne (A) de l'embout (5) de la seringue de manière à pouvoir insérer facilement mais en force la protubérance dans l'alésage.2.- container according to claim 1, characterized in that the projection is a protuberance (4) which is in the form of a substantially rectangular surface of width corresponding to the diameter of the internal bore (A) of the tip (5) of the syringe so that the protuberance can be easily but easily inserted into the bore.
3.- Récipient selon la revendication 2, caractérisé en ce que la largeur de la protubérance est supérieure au diamètre de l'alésage (A) de l'embout (5).3.- container according to claim 2, characterized in that the width of the protuberance is greater than the diameter of the bore (A) of the nozzle (5).
4.- Récipient selon la revendication 3, caractérisé en ce que la protubérance (4) est insérée par ovalisation dans l'alésage (A) de l'embout (5).4.- container according to claim 3, characterized in that the protuberance (4) is inserted by ovalization in the bore (A) of the nozzle (5).
5.- Récipient selon l'une quelconque des revendications précédentes, caractérisé en ce que la protubérance (4) est orientée par rapport au plan supérieur du récipient (1 ) selon un angle variant entre environ plus ou moins 30 degrés.5. Container according to any one of the preceding claims, characterized in that the protuberance (4) is oriented relative to the upper plane of the container (1) at an angle varying between approximately plus or minus 30 degrees.
6.- Récipient selon l'une quelconque des revendications précédentes, caractérisé en ce que l'embout de seringue est choisi entre l'embout d'aiguille et l'embout de piston. 6.- Container according to any one of the preceding claims, characterized in that the syringe tip is chosen between the needle tip and the plunger tip.
7.- Récipient selon la revendication 1 , caractérisé en ce que l'avancée se présente sous la forme d'une patte trouée (4') selon un trou circulaire (6) dont le diamètre est sensiblement égal au diamètre externe de l'embout (5) au niveau de la collerette (7) de cet embout. 7.- A container according to claim 1, characterized in that the projection is in the form of a perforated tab (4 ') according to a circular hole (6) whose diameter is substantially equal to the external diameter of the nozzle. (5) at the flange (7) of this nozzle.
8.- Récipient selon la revendication 7, caractérisé en ce que la patte (4') est orientée sensiblement dans un plan perpendiculaire au plan supérieur du récipient (1 )8.- container according to claim 7, characterized in that the tab (4 ') is oriented substantially in a plane perpendicular to the upper plane of the container (1)
9.- Récipient selon la revendication 7, caractérisé en ce que la patte (4') est orientée sensiblement parallèlement au plan supérieur du récipient (1 )9. A container according to claim 7, characterized in that the tab (4 ') is oriented substantially parallel to the upper plane of the container (1)
10.- Récipient selon la revendication 1 , caractérisé en ce que l'avancée est formée par une surface sensiblement cylindrique (4") dont les bords (4a, 4b) se font face jusqu'à définir une fente (F).10.- A container according to claim 1, characterized in that the projection is formed by a substantially cylindrical surface (4 ") whose edges (4a, 4b) face each other until defining a slot (F).
11.- Récipient selon la revendication 10, caractérisé en ce que le diamètre de cette surface cylindrique (4") correspond au diamètre externe de l'embout (5) de l'aiguille de la seringue.11.- container according to claim 10, characterized in that the diameter of this cylindrical surface (4 ") corresponds to the external diameter of the nozzle (5) of the needle of the syringe.
12.- Récipient selon la revendication 11 , caractérisé en ce que la collerette (7) est disposée en butée contre le bord circulaire de la surface cylindrique (4") disposé du côté du récipient (1 ). 12.- container according to claim 11, characterized in that the collar (7) is disposed in abutment against the circular edge of the cylindrical surface (4 ") disposed on the side of the container (1).
13.- Récipient selon la revendication 1 , caractérisé en ce que plusieurs avancées sont disposées le long de la bordure (2) d'un même récipient (1 ) de manière à permettre la connexion entre l'une de ces avancées et tout type de dimension d'embout de seringue (5) ou d'autre élément adaptable utilisé dans un kit de préparation et d'injection. 13.- container according to claim 1, characterized in that several projections are arranged along the edge (2) of the same container (1) so as to allow the connection between one of these projections and any type of size of syringe tip (5) or other adaptable element used in a preparation and injection kit.
14.- Kit de préparation et d'injection de médicaments et de produits actifs contenant notamment un récipient de mélange selon l'une quelconque des revendications précédentes et une seringue munie d'un embout d'aiguille et d'un embout de piston.14.- Kit for preparing and injecting drugs and active products containing in particular a mixing container according to any one of the preceding claims and a syringe provided with a needle tip and a plunger tip.
15.- Kit selon la revendication 14, caractérisé en ce qu'un filtre d'impureté (12) est monté dans l'embout (9) de la seringue (8) pour filtrer directement le médicament ou le produit actif dans le corps de la seringue avant leur injection..15.- Kit according to claim 14, characterized in that an impurity filter (12) is mounted in the nozzle (9) of the syringe (8) for filtering directly the drug or the active product in the body of the syringe before their injection.
16.- Kit selon la revendication 14, dans le cas où la seringue est équipée d'un embout classique, dans lequel est disposé au moins un embout filtrant selon la revendication 15 pour être adapté sur l'aiguille de la seringue à la place dudit embout classique lors de la filtration.16.- Kit according to claim 14, in the case where the syringe is equipped with a conventional tip, in which is disposed at least one filtering tip according to claim 15 to be adapted on the needle of the syringe in place of said classic nozzle during filtration.
17.- Kit selon la revendication 15, caractérisé en ce que l'embout (9) est recouvert d'un capuchon (13) dont l'intérieur est stérile pour protéger le filtre (12) qu'il recouvre. 17.- Kit according to claim 15, characterized in that the end piece (9) is covered with a cap (13) whose interior is sterile to protect the filter (12) which it covers.
18. Kit selon l'une quelconque des revendications 15 à 17, caractérisé en ce que la surface du filtre (12) en regard de l'aiguille (10) est inclinée afin d'épouser la surface d'extrémité biseautée de l'aiguille (10).18. Kit according to any one of claims 15 to 17, characterized in that the surface of the filter (12) facing the needle (10) is inclined so as to match the beveled end surface of the needle (10).
19.- Kit selon l'une quelconque des revendications 14 à 18, caractérisé en ce que la seringue est préremplie d'eau stérile. 19.- Kit according to any one of claims 14 to 18, characterized in that the syringe is pre-filled with sterile water.
PCT/FR1998/000947 1997-05-12 1998-05-12 Receptacle for preparing medicines and injection kit containing same and filtering adapter WO1998051356A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002290667A CA2290667A1 (en) 1997-05-12 1998-05-12 Receptacle for preparing medicines and injection kit containing same and filtering adapter
AU76629/98A AU7662998A (en) 1997-05-12 1998-05-12 Receptacle for preparing medicines and injection kit containing same and filtering adapter
EP98924423A EP0981382A1 (en) 1997-05-12 1998-05-12 Receptacle for preparing medicines and injection kit containing same and filtering adapter

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR97/05782 1997-05-12
FR9705782A FR2762995B1 (en) 1997-05-12 1997-05-12 DRUG PREPARATION CONTAINER AND KIT CONTAINING SUCH A CONTAINER
FR97/15746 1997-12-12
FR9715746A FR2772279B1 (en) 1997-12-12 1997-12-12 STERILIZED AND BLISTERIZED ASSEMBLY FOR SELF-INJECTION OF ACTIVE PRODUCTS AND MEDICINES

Publications (1)

Publication Number Publication Date
WO1998051356A1 true WO1998051356A1 (en) 1998-11-19

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PCT/FR1998/000947 WO1998051356A1 (en) 1997-05-12 1998-05-12 Receptacle for preparing medicines and injection kit containing same and filtering adapter

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EP (1) EP0981382A1 (en)
AU (1) AU7662998A (en)
CA (1) CA2290667A1 (en)
WO (1) WO1998051356A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2841789A1 (en) 2002-07-05 2004-01-09 Elliot Imbert DEVICE FOR PREPARING A PHARMACEUTICAL OR MEDICINAL PRODUCT, ESPECIALLY INJECTABLE
WO2006064231A1 (en) * 2004-12-16 2006-06-22 Frontier Plastics Limited Improvements relating to injection syringes and needles

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1876493A (en) * 1930-01-09 1932-09-06 Frutkow Nathaniel Hypodermic kit and the like
US2698996A (en) * 1951-07-30 1955-01-11 Frederick R Hickerson Food or medicine administering spoon
GB938777A (en) * 1961-09-11 1963-10-09 Brunswick Corp Ejector package
US5377879A (en) * 1993-12-22 1995-01-03 Isaacs; Linda R. F. Measuring spoon
US5429600A (en) * 1994-05-02 1995-07-04 Heinke; Richard M. Method for delivering a pharmaceutical into the nostril of an animal
FR2722412A3 (en) * 1994-07-18 1996-01-19 B Braun Medical Ag Appts. is sterilisable set for self-injection of drugs
GB2295076A (en) * 1994-11-19 1996-05-22 Hyun Lim Medicine spoon

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1876493A (en) * 1930-01-09 1932-09-06 Frutkow Nathaniel Hypodermic kit and the like
US2698996A (en) * 1951-07-30 1955-01-11 Frederick R Hickerson Food or medicine administering spoon
GB938777A (en) * 1961-09-11 1963-10-09 Brunswick Corp Ejector package
US5377879A (en) * 1993-12-22 1995-01-03 Isaacs; Linda R. F. Measuring spoon
US5429600A (en) * 1994-05-02 1995-07-04 Heinke; Richard M. Method for delivering a pharmaceutical into the nostril of an animal
FR2722412A3 (en) * 1994-07-18 1996-01-19 B Braun Medical Ag Appts. is sterilisable set for self-injection of drugs
GB2295076A (en) * 1994-11-19 1996-05-22 Hyun Lim Medicine spoon

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2841789A1 (en) 2002-07-05 2004-01-09 Elliot Imbert DEVICE FOR PREPARING A PHARMACEUTICAL OR MEDICINAL PRODUCT, ESPECIALLY INJECTABLE
WO2006064231A1 (en) * 2004-12-16 2006-06-22 Frontier Plastics Limited Improvements relating to injection syringes and needles

Also Published As

Publication number Publication date
CA2290667A1 (en) 1998-11-19
AU7662998A (en) 1998-12-08
EP0981382A1 (en) 2000-03-01

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