WO1998050005A1

WO1998050005A1 - Compositions for cosmetic applications

Info

Publication number: WO1998050005A1
Application number: PCT/US1998/009211
Authority: WO
Inventors: Eyal S. Ron; Barry J. Hand; Lev S. Bromberg; Marie Kearney; Matthew E. Schiller; Peter M. Ahearn; Scott Luczak; Thomas H. E. Mendum
Original assignee: Medlogic Global Corporation
Priority date: 1997-05-09
Filing date: 1998-05-08
Publication date: 1998-11-12
Also published as: EP1011609A4; EP1011609A1; AU7472398A

Abstract

A cosmetic composition is described having a cosmetically acceptable carrier, comprising a reverse thermal viscosifying polymer network comprising at least one poloxamer component capable of aggregation in response to a change in temperature randomly bonded to at least one poly(acrylic acid) component; and a cosmetically active agent which imparts a preselected cosmetic effect, said carrier and said agent disposed within an aqueous-based medium.

Description

COMPOSITIONS FOR COSMETIC APPLICATIONS

This application is a continuation-in-part application of copending application U.S.S.N. 60/034,805 filed January 2, 1997, and entitled "Responsive Polymer Networks and Methods of Their Use", which is a continuation-in-part application of copending application PCT/US96/ 10376 filed June 14, 1996, designating the United States, and entitled "Responsive Polymer Networks and Methods of Their Use", which is a continuation-in-part application of copending application U.S.S.N. 08/580, 986 filed January 3, 1996, and entitled "Responsive Polymer Networks and Methods of Their Use", each of which is incorporated entirely by reference.

Field of the Invention The present invention relates to a cosmetic composition useful in a variety of topical and personal care products, including treatments of disorders and imperfections of the skin or other areas of the body. More particularly, the present invention is directed to a cosmetic composition comprising a poloxamer:poly(acrylic acid) polymer network that can be designed to reversibly gel over a wide range of conditions to provide a composition having a controllable range of viscosities, making it useful in a variety of cosmetic and personal care applications.

Background of the Invention Many examples are known of cosmetic compositions intended for treatment of the skin or elsewhere on the body, where it is desired to have certain properties of viscosity. Hydrogels, such as cellulosics, have been included as thickeners in cosmetic compositions. A hydrogel is a polymer network which absorbs a large quantity of water without the polymer dissolving in water. The hydrophilic areas of the polymer chain absorb water and form a gel region. The extent of gelation depends upon the volume of the solution which the gel region occupies.

Reversibly gelling solutions are known in which the solution viscosity increases and decreases with an increase and decrease in temperature, respectively. Such reversibly gelling systems are useful wherever it is desirable to handle a material in a fluid'state, but performance is preferably in a gelled or more viscous state.

A known material with these properties is a thermal setting gel using block copolymer polyols, available commercially as Pluronic^® polyols (BASF, Ludwigshafen, Germany), which is described in U.S. Patent No. 4, 188, 373. Adjusting the concentration of the polymer gives the desired liquid-gel transition. However, concentrations of the polyol polymer of at least 18-20% by weight are needed to produce a composition which exhibits such a transition at commercially or physiologically useful temperatures. Also, solutions containing 18-20% by weight of responsive polymer are typically very viscous even in the "liquid" phase, so that these solutions can not function under conditions where low viscosity, free-flowing is required prior to transition. In addition, these polymer concentrations are so high that the material itself may cause unfavorable interactions during use.

Another known system which is liquid at room temperature, but forms a semi- solid when warmed to about body temperature is formed from tetrafunctional block polymers of polyoxyethylene and polyoxypropylene condensed with ethylenediamine, commercially available at Tetronic^® polyols. These compositions are formed from approximately 10% to 5-% by weight of the polyol in an aqueous medium. See, U.S. Patent No. 5,252,318. Joshi, et al. in U.S. Patent No. 5,252,318 reports reversible gelling compositions which are made up of a physical blend of a pH-sensitive gelling polymer (such as a cross-linked poly(acrylic acid) and a temperature-sensitive gelling polymer (such as methyl cellulose or block copolymers of poly(ethyleneoxide) and poly(propyleneoxide)). In compositions including methylcellulose, 5- to 8-fold increases in viscosity are observed upon a simultaneous change in temperature and pH for very low methylcellulose levels (1-4% by weight). See, Figs. 1 and 2 of Joshi, et al. In compositions including Pluronic^® and Tetronic^® polyols, commercially available forms of poly(ethyleneoxide)/poly(propyleneoxide) block copolymers, significant increases in viscosity (5- to 8-fold) upon a simultaneous change in temperature and pH are observed only at much higher polymer levels. See, Figs. 3-6 of Joshi, et al. Hoffman, et al. in WO95/24430 disclose block and graft copolymers comprising a pH-sensitive polymer component and a temperature-sensitive polymer component. The block and graft copolymers are well-ordered and contain regularly repeating units of the pH-sensitive and temperature-sensitive polymer components. The copolymers are described as having a lower critical solution temperature (LCST), at which both solution-to-gel transition and precipitation phase transition occur. Thus, the transition to a gel is accompanied by the clouding and opacifϊcation of the solution. Light transmission is reduced, which may be undesirable in many applications, where the aesthetic characteristics of the composition are of some concern. Thus, the known systems which exhibit reversible gelation are limited in that they require large solids content and/or in that the increase in viscosity is less than 10- fold. In addition, some known systems exhibit an increase in viscosity which is accompanied with the undesirable opacification of the composite.

Summary of the Invention

It is an object of the present invention to provide a cosmetic composition which includes a component capable of reversible gelation or viscosification.

It is a further object of the invention to provide a cosmetic composition which includes an ingredient capable of gelation or viscosification at very low solids content. It is another object of the present invention to provide a cosmetic composition which possesses improved flow and gelation characteristics as compared to properties possessed by conventional reversible gelation compositions.

It is a further object of the invention to provide a polymer network composition for use in cosmetic compositions useful as a surfactant or emulsifier in the solubilization of additives and, in particular, hydrophobic additives.

It is a further object of the invention to provide a cosmetic composition which possesses the appropriate thickness, emolliency and cosmetic effect with a minimum of solids content.

It is a further object of the invention to provide a polymer network for use in cosmetic compositions useful as a suspending agent for otherwise insoluble additives. It is yet a further object of the present invention to provide a composition capable of solubilizing emulsions at elevated temperatures.

It is yet a further object of the invention to provide new and useful cosmetic compositions incorporating the reversibly gelling polymer network composition of the present invention, which take advantage of its unique advantageous properties.

It is yet another object of the present invention to provide reversibly gelling polymer network compositions which are composed of biocompatible polymers.

These and other objects of the invention are achieved with a cosmetic compositions which incorporates a poloxamer:poly(acrylic acid) polymer network as a cosmetically acceptable carrier. The polymer network comprises a poloxamer component randomly bonded to a poly(acrylic acid), or PAA, component in and aqueous-based medium, the polymer network being capable of aggregating in response to an increase in temperature. The reverse thermal viscosifying poloxamer :poly(acry lie acid) polymer network includes random covalent bonding between the poly(acrylic acid) component and the poloxamer component of the network. The polymer network may also include some unbound or "free" poloxamer or other additives which contribute to or modify the characteristic properties of the polymer composition.

In addition, the cosmetic composition includes a cosmetic agent selected to provide a preselected cosmetic effect. By "cosmetic agent", as that term is used herein, it is meant that the additive imparts a cosmetic effect. A cosmetic effect is distinguishable from a pharmaceutical effect in that a cosmetic effect relates to the promoting bodily attractiveness or masking the physical manifestation of a disorder or disease. In contrast, a pharmaceutic seeks to treat the source or symptom of a disease or physical disorder. It is noted however, that the same additives may have either a cosmetic or pharmaceutical effect, depending upon the amounts used and the manner of administration.

By "cosmetic", as that term is used herein, it is meant the cosmetic and personal- care applications intended to promote bodily attractiveness or to cover or mask the physical manifestations of a disorder or disease. Cosmetics include those products subject to regulation under the FDA cosmetic guidelines, as well as sunscreen products, acne products, skin protectant products, anti-dandruff products, and deodorant and antiperspirant products.

By "gelation" or viscosification, as that term is used herein, it is meant a drastic increase in the viscosity of the polymer network solution. Gelation is dependent on the initial viscosity of the solution, but typically a viscosity increase in the range of 2- to 100-fold, and preferably 5- to 50-fold, and more preferably 10- to 20-fold is observed in the polymer network which is used in the preparation of the cosmetic compositions of the invention. Such effects are observed in a simple polymer network solution and the effect may be modified by the presence of other components in the cosmetic composition.

By "reversibly gelling" as that term is used herein, it is meant that the process of gelation takes place upon an increase in temperature rather than a decrease in temperature. This is counter- intuitive, since it is generally known that solution viscosity decreases with an increase in temperature. As used herein, "poloxamer" is a triblock copolymer derived from poly(ethyleneoxide)-poly(propyleneoxide)-poly(ethyleneoxide) blocks. The poloxamer is capable of responding to a change in temperature by altering its degree of association and/or agglomeration. The aggregation may be in the form of micelle formation, precipitation, labile cross-linking or other factors. The poloxamer has the general formula of a triad ABA block copolymer, (P_ι)_a(P₂)_b(P_ι)_a where Pj =poly(ethyleneoxide) and P₂=poly(propyleneoxide) blocks, where a is in the range of 10-50 and where b is in the range of 50-70.

The poly(acrylic acid) component includes poly(acrylic acid) and its salts. The poly(acrylic acid) supports and interacts with the poloxamer component so that a multi- material, responsive polymer network is formed. The interaction of the poloxamer and poly(acrylic acid) exhibits a synergistic effect, which magnifies the effect of the poloxamer component in viscosifying and/or gelling the solution.

The novel interaction between the constituent polymers components of the polymer network permits formation of gels at very low solids content. Gelation and/or viscosification is observed in aqueous solutions having about 0.01 to 20 wt% of the poloxamer component and about 0.01 to 20 wt% of the poly(acrylic acid) component. A typical reversibly gelling polymer network may be comprised of less than about 4 wt% of total polymer solids (e.g., poloxamer and poly(acrylic acid)) and even less than 1 wt% total polymer solids while still exhibiting reverse thermal viscosification. Of course, the total solids content including additives of a reversibly gelling polymer network composition may be much higher. The viscosity of the gel increases at least ten-fold with an increase in temperature of about 5°C at pH 7 and 1 wt% polymer. Viscosity increases may be even greater over a larger temperature range at pH 7 and 1 % polymer network content. The relative proportion of poloxamer and poly (acrylic acid) may vary dependent upon the desired properties of the polymer composition. In one embodiment, the poloxamer is present in a range of about 1 to 20 wt% and the poly (acrylic acid) is present in a range of about 99 to 80 wt% . In another embodiment, the poloxamer component is present in a range of about 79 to 60 wt% . In another embodiment, the poloxamer component is present in a range of about 41 to 50 wt% . In another embodiment, the poloxamer component is present in a range of about 51 to 60 wt% and the poly (aery lie acid) component is present in a range of about 49 to 40 wt%. In yet another embodiment, the poloxamer component is present in a range of about 61 to 90 wt% and the poly(acrylic acid) component is present in a range of about 39 to 20 wt%. In another embodiment, the poloxamer component is present in a range of about 81 to 99 wt% and the poly(acrylic acid) component is present in a range of about 10 to 1 wt% .

The poloxamer:poly(acrylic acid) polymer network described above is included in a cosmetic composition to improve the flow characteristics, thickness and other properties of the composition. The composition includes additional cosmetic agents, such as are needed for the cosmetic purpose of the composition. Additives also may be included to modify the polymer network performance, such as to increase or decrease the temperature of the liquid-to-gel transition and/or to increase or decrease the viscosity of the responsive polymer composition. In one aspect of the invention, the poloxamer:poly(acrylic acid) polymer network is incorporated into a cosmetic composition to impart thickening properties to the cosmetic composition at the use and/or application temperature. Such thickening properties include enhanced overall viscosity, as well as a desirable viscosity response with temperature. The polymer network may be useful as a thickener in pH ranges where other thickeners are not effective.

In another aspect of the invention, the poloxamer:poly(acrylic acid) polymer network is incorporated into a cosmetic composition to stabilize and solubilize hydrophobic agents in the cosmetic composition. The polymer network may be included to increase emulsion stability. Many emulsions, i.e., suspension of small droplets or particles of a first material in a second material, lose viscosity upon heating. As will be demonstrated herein, the poloxamer:poly(acrylic acid) polymer network retains its emulsifying properties even with temperature increase.

In addition, it may be included in the composition to impart emolliency to the composition. The composition may also act as a film-forming agent after it has been applied to the skin. This film-forming agent may be used as a barrier to prevent water loss from the skin which contributes to the moisturization of the skin.

In another aspect of the invention, the poloxamer: poly (aery lie acid) polymer network may be included as an additive in cosmetic applications to prevent viscosity loss at elevated temperatures.

Brief Description of the Drawing The invention is described with reference to the Drawing, which is presented for the purpose of illustration and is in no way intended to be limiting, and in which: FIG. 1 is a graph of viscosity vs. temperature for a 1 wt%, 2 wt% , and 3 wt% responsive polymer network aqueous composition of a poloxamer:poly(acrylic acid) (1:1) at pH 7.0 measured at a shear rate of 0.44 sec¹;

FIG. 2 is a graph of viscosity vs. temperature for a 1 wt% poloxamer:poly(acrylic acid) polymer network composition demonstrating reversibility of the viscosity response; FIG. 3 shows the viscosity response of a 2 wt% poloxamer: poly (aery lie acid) polymer composition at various shear rates;

FIG. 4 shows a viscosity response curve for a 2 wt% poloxamer:poly(acrylic acid) polymer network composition prepared with nominal mixing and stirring and prepared using high shear homogenization (8000 rpm, 30 min);

FIG. 5 is a graph of viscosity vs. temperature for a 1 wt% poloxamer :poly(acry lie acid) polymer network composition at various pHs;

FIG. 6 is a graph of viscosity vs. temperature for a 1 wt% poloxamer:poly(acrylic acid) polymer network composition with and without addition of 0.25 wt% KCl;

FIG. 7 is a graph of viscosity vs. temperature for a 1 wt% poloxamer:poly(acrylic acid) polymer network composition with and without addition of 0.5 wt% acetamide ME A;

FIG. 8 is a graph of viscosity vs. temperature for a 1 wt% poloxamer:poly(acrylic acid) polymer network composition without and with 5 wt%, 10 wt% and 20 wt% added ethanol, respectively;

FIG. 9 is an illustration of a reversibly gelling polymer network used as an emulsifier and stabilizer for a hydrophobic agent;

FIG. 10 is a schematic illustration of the poloxamer:poly(acrylic acid) polymer network below and above the transition temperature illustrating the aggregation of the hydrophobic poloxamer regions;

FIG. 11 is a graph of viscosity vs. pH for a 1 wt% responsive polymer network aqueous composition of a poloxamer/poly (aery lie acid) (1: 1) measured at a shear rate of 0.44 sec ¹; FIG. 12 is a plot of viscosity vs. temperature for (a) a 1 wt% responsive polymer network aqueous composition of Pluronic^® F127 poloxamer: poly (acrylic acid) (1:1) and (b) a 1 wt% physical blend of Pluronic^® F127 poloxamer:poly(acrylic acid) (1:1) at pH 7.0 measured at a shear rate 0.22 sec¹; FIG. 13 is a plot of viscosity vs. temperature for a 1 wt% responsive polymer network aqueous composition of Pluronic^® F88 poloxamer:poly(acrylic acid) (1:1) in deionized water at pH 7.0 measured at shear rate of 22 sec¹;

FIG. 15 is a plot of viscosity vs. temperature for a responsive polymer network composition of 2 wt% Pluronic^® F123 poloxamer:poly(acrylic acid) (1 : 1) at pH 7.0 measured at a shear rate of 22 sec ¹;

FIG.16 is a plot of viscosity vs. temperature for 1 wt% made of series of poloxamers and poly(acrylic acid) (1:1) in deionized water at a shear rate of 132 sec¹;

FIG. 17 is a plot showing release of hemoglobin from a poloxamer:poly(acrylic acid) polymer network of the invention;

FIG. 18 is a plot showing the release of lysozyme from the poloxamer:poly(acrylic acid) polymer complex of the invention;

FIG. 19 is a plot showing release of insulin from a poloxamer:poly(acrylic acid) polymer network composition of the invention; FIG. 20 is a plot of viscosity vs. temperature for a poloxamer:poly(acrylic acid) polymer network composition (a) before and (b) after sterilization by autoclave;

FIG. 21 is a plot of viscosity vs. temperature for an oil-free moisturizing formulation prepared form (a) a responsive polymer network composition of the invention and (b) a convention oil-in-water formulation; FIG. 22 is a plot of equilibrium solubility of estradiol (A, B) and progesterone

(C, D) in aqueous solutions (pH 7) of Pluronic^® F127 (A, C) and responsive polymer network (B, D) vs. temperature;

FIG. 23 is a plot of the ratio of equilibrium solubilities of estradiol in responsive polymer network and water vs. polymer concentration in the responsive polymer network solutions;

FIG. 24 is a plot of the effect of loading fluorescein on the onset of gelation of responsive polymer network vs. total polymer concentration in responsive polymer network solution (pH 7.0);

FIG. 25 is a plot of the percentage of (a) estradiol and (b) progesterone release from responsive polymer network vs. time; FIG. 26 is a plot of the rate of progesterone release and macroscopic viscosity vs. polymer concentration;

FIG. 27 is a plot of the percentage of progesterone release vs. polymer concentration in responsive polymer network; and FIG. 28 is a plot of the relative diffusivity of poly(styrene) latex particles in water and responsive polymer network.

Detailed Description of the Invention The present invention is directed to a cosmetic composition comprising a cosmetically acceptable carrier comprising a novel poloxamer:poly(acrylic acid) polymer network. The polymer network functions as a temperature sensitive thickening agent, and in addition possesses surfactant and emulsifying capabilities which may be beneficial to the cosmetic composition. The polymer network composition according to the invention includes a poloxamer component randomly bonded to a poly(acrylic acid) component. The two polymer component may interact with one another on a molecular level. The polymer network contains about 0.01 - 20 wt% each of poloxamer and poly (acrylic acid). Exemplary polymer network compositions range from about 1 :10 to about 10:1 poloxamer:poly(acrylic acid). Polymer network gel compositions which exhibit a reversible gelation at body temperature (25-40°C) and/or at physiological pH (ca. pH 3.0-9.0) and even in basic environment up to pH 13 (hair care) are particularly preferred for cosmetic applications.

In one embodiment of the invention, a 1:1 poloxamer: poly (acrylic acid) polymer network at appropriate pH exhibits flow properties of a liquid at about room temperature, yet rapidly thickens into a gel consistency of at least about five times greater, preferably at least about 10 times greater, and even more preferably at least about 30 times and up to 100 times greater, viscosity upon increase in temperature of about 10 °C and preferably about 5°C. The reversibly gelling polymer network of the present invention exhibit gelation even at very low polymer concentrations. For example, polymer network compositions at pH 7 comprising about 0.5 wt% poloxamer component and about 0.5 wt% PAA exhibits a significant increase in viscosity from a free-flowing liquid (50 cps) to a gel (6000 cps). The observed gelation takes place at low solids contents, such as less than 20 wt% or preferably less than about 10 wt% , of more preferably less than about 2.5 wt% or most preferably less than about 0.1 wt% . Thus, only a small amount by weight of the polymer network need be incorporated into a cosmetic composition in order to provide the desired thickening or viscosifying effect. The reverse viscosification effect at low polymer concentrations provides clear, colorless gels which are particularly well-suited to cosmetic applications. For example, very little residue is formed upon dehydration which may be important in some applications, such as in topically applied cosmetics. An additional advantage of the polymer network of the invention is that it remains clear and translucent above and below the critical temperature or pH. These characteristics of the reversibly gelling polymer network make it well suited for use in cosmetic compositions.

The polymer network of the present invention technology may be added to cosmetic formulations to increase the thickness and viscosity of the composition. The poloxamer:poly(acrylic acid) polymer network possesses hydrophobic regions capable of aggregation. Unlike conventional thickeners, the aggregation of the polymer network of the present invention is temperature sensitive. Thus the inventive polymer network of the present invention may have a transition temperature (i.e., temperature of aggregation) above room temperature so that the cosmetic composition is of low viscosity at or below room temperature and is of high viscosity at or around body temperature (body temperature includes both surface and internal body temperature). Thus, a composition may be prepared at low temperatures while the polymer network is in a low viscosity state. Mixing of ingredients under low viscosity is expected to be easier, thus simplifying the manufacturing process. Yet, the resultant mixture would be of increased viscosity at use temperatures. As a further advantage, a cosmetic composition comprising poloxamer:poly(acrylic acid) polymer network may be spread thinly to allow for even application, due to its low viscosity at room temperature, but will thicken and "fill" the skin contours upon warming up to body surface temperature. In another aspect of the invention, the composition may be applied through a nozzle that provides high shear to reduce viscosity, yet the composition regains its viscosity after application to the skin. This contrasts with conventional formulations whiclϊ permanently lose viscosity after being subjected to high shear.

In another aspect of the invention, the composition may be formulated and applied as a liquid, spray, semi-solid gel, cream, ointment, lotion, stick, roll-on formulation, mousse, pad-applied formulation, and film-forming formulation.

The poloxamer:poly(acrylic acid) polymer network may also be included in a cosmetic composition for use as a stabilizing, solubilizing or emulsifying agent for a hydrophobic component of the cosmetic formulation. The strong hydrophilic regions of the poloxamer resulting from aggregation and micelle formation create hydrophobic domains which may be used to solubilize and control release of hydrophobic agents. Similar micelle-based systems have been shown to protect trapped peptides against enzymatic degradation from surface enzymes.

The reversibly gelling polymer network of the present invention is a unique polymer composition designed to abruptly change its physical characteristics or the characteristics and properties of materials mixed therewith with a change in temperature. Without intending to be bound by any particular mechanism or chemical structure, it is believed that the structure of the polymer network involves a random bonding of the poloxamer onto the backbone of the poly(acrylic acid). A portion of the poloxamer which is present during the polymerization reaction which forms the poly(acrylic acid) is bonded to the backbone of the forming poly(acrylic acid) through hydrogen abstraction and subsequent reaction. See detailed discussion of the mechanism, below. The combination of the poly(acrylic acid) and randomly bonded poloxamer gives the composition its unique properties. Any free poloxamer remaining after polymerization of PAA remains associated with the random co-polymer, resulting in a miscible composition. Free poloxamer may also be present in the polymer network composition; however, its presence is not required in or der to observe reverse thermal viscosification.

The poly(acrylic acid) may be linear, branched and/or cross-linked. Poly(acrylic acid) is capable of ionization with a change in pH of the solution. By ionization, as that term is used with respect to poly (acrylic acid), it is meant the formation of the conjugate base of the acrylic acid, namely acrylate. As used herein, poly(acrylic acid) includes both ionized and non-ionized versions of the polymer. Changes in ionic strength may be accomplished by a change in pH or by a change in salt concentration. The viscosifying effect of the polymer network is partly a function of the ionization of the poly(acrylic acid); however, reverse thermal gelling may occur without ionization. Changes to the ionic state of the polymer causes the polymer to experience attractive (collapsing) or repulsive (expanding) forces. Where there is no need or desire for the composition to be applied in a high viscosity state, it may be possible to prepare the composition as non-ionized poly (acrylic acid). The body's natural buffering ability will adjust the pH of the applied composition to ionize the poly(acrylic acid) and thereby develop its characteristic viscosity.

The poloxamer possesses regions of hydrophobic character, e.g., poly(propyleneoxide) blocks, and hydrophilic character, e.g., poly(ethyleneoxide) blocks. The poloxamer may be linear or branched. Suitable poloxamers include triad block copolymers of poly(ethyleneoxide) and poly(propyleneoxide) having the general formula (P_)_a(P₂)_b(P_ι)_a, where P, = poly(ethyleneoxide), and P₂ = poly(propyleneoxide) blocks, where a is in the range of 10-50 and where b is in the range of 50-70, where poly(propyleneoxide) represents the hydrophobic portion of the polymer and poly(ethyleneoxide) represents the hydrophilic portion of the polymer. Pluronic^® polymers (BASF) are commercially available for (a) in the range of 16 to 48 and (b) ranging from 54-62. One or more poloxamers may be used in the reversibly gelling polymer network composition of the present invention.

The reversibly gelling responsive polymer networks compositions of the present invention are highly stable and do not exhibit any phase separation upon standing or upon repeated cycling between a liquid and a gel state. Samples have stood at room temperature for more than three months without any noticeable decomposition, clouding, phase separation or degradation of gelation properties. This is in direct contrast to polymer blends and aqueous mixed polymer solutions, where phase stability and phase separation is a problem, particularly where the constituent polymers are immiscible in one another. And example of the dramatic increase in viscosity and of the gelation of the reversibly gelling polymer network compositions of the invention is shown in Figure 1'. Figure 1 is a graph of viscosity vs. temperatures for 1 wt% , 2 wt% , and 3 wt% polymer network compositions comprising 1 : 1 poloxamer:poly(acrylic acid) hydrated and neutralized. The viscosity measurements were taken on a Brookfield viscometer at a shear rate of 0.44 sec ¹ at pH 7.0. All solutions had an initial viscosity of about 1080 cP and exhibited a dramatic increase in viscosity to gel point at about 35 °C. This is not typical of all polymer network compositions since polymerization condition will affect initial viscosity. Final viscosities were approximately 33,000 cP, 100,000 cP and 155,000 cP for the 1 wt% , 2 wt% and 3 wt% compositions, respectively. This represents viscosity increases of about 30-, 90- and 140-fold, respectively. This effect is entirely reversible. Upon cooling, the composition regains its initial viscosity. This is demonstrated in Figure 2, where a 1 wt% poloxamer:poly(acrylic acid) composition is warmed through the transition temperature up to 35 °C (simple curve), cooled to room temperature (24°C, ticked curve) and then warmed again up to above the transition temperature (open box curve). The viscosity response was virtually identical in all three instances.

As would be expected with a non-Newtonian system, the solution viscosity differs with different shear rates. Figure 3 shows the viscosity response of a 2 wt% poloxamer:poly(acrylic acid) polymer composition at various shear rates. The viscosity response is consistent between 24°C and 34°C; however, the final viscosity is reduced with increasing shear rate.

However, unlike many prior art hydrogels, e.g., carbomers, the poloxamer:poly(acrylic acid) polymer network composition does not permanently loose viscosity after being subjected to high shear conditions. The poloxamer :poly(acrylic acid) polymer network composition remains unaffected by such shear conditions as homogenization. Figure 4 compares the viscosity response curve of a 2 wt% poloxamer:poly(acrylic acid) polymer composition prepared with nominal mixing (simple line) and stirring with that of a polymer composition of similar composition prepared using high shear homogenization designated by a ticked line (8000 rpm, 30 min)/ No significant decrease in viscosity is observed.

A number of factors influence the viscosity and transition temperature of the composition. The more important factors include polymer concentration, pH, and presence and nature of additives.

The effect of pH on the viscosity of reversibly gelling polymer networks is shown in Figure 5. Increasing pH from the starting pH has a lesser effect on the viscosity than decreasing the pH. This may relate to the extent of ionization of the poly (aery lie acid) component of the polymer network as discussed above. This may be clearly seen in Figure 5 when comparing the viscosity response of a 1 wt% poloxamer:poly(acrylic acid) polymer composition at pH 5 and pH 11. Satisfactory viscosities can be obtained at high pHs indicating the potential value of the reversibly gelling polymer network in products such as depilatories, hair straighteners and hair relaxers. The responsive polymer network may also include additives for influencing the performance of the polymer composition, such as the transition temperature and the viscosity of the polymer composition above the transition temperature. The following list is not intended to be exhaustive but rather illustrative of the broad variety of additives which can be used. These materials include solvents (e.g., 2-propanol, ethanol, acetone, 1,2- pyrrolidinone, N-methylpyrrolidinone), salts (e.g., calcium chloride, sodium chloride, potassium chloride, sodium or potassium phosphates, borate buffers, sodium citrate), preservatives (benzalkonium chloride, phenoxy ethanol, sodium hydroxymethylglycinate, ethylparaben, benzoyl alcohol, methylparaben, propylparaben, butylparaben, Germaben II), humectant/moismrizers (acetamide MEA, lactimide MEA, hydrolyzed collagen, mannitol, panthenol, glycerin), lubricants (hyaluronic acid, mineral oil, PEG-60-lanolin, PPG-12-PEG-50-lanolin, PPG-2 myristyl ether propionate) and surfactants.

Surfactants may be divided into three classes: cationic, anionic, and non-ionics. An example of a cationic surfactant used is ricinoleamidopropyl ethyldimonium ethosulfate (Lipoquat R). Anionic surfactants include sodium dodecyl sulfate and ether sulfates such as Rhodapex CO-436. Nonionic surfactants include Surfynol CT-111, TG, polyoxyethylene sorbitan fatty acid esters such as Tween 65 and 80, sorbitan fatty acid esters such as Span 65, alkylphenol ethoxylates such a Igepal CO-210 and 430, dimethicone copolyols such as Dow Corning 190, 193, and Silwet L7001.

The addition of polymers has been studied including xanthan gum, cellulosics such as hydroxyethylcellulose (HEC), carbomethoxycellulose (CMC), lauryldimonium hydroxypropyl oxyethyl cellulose (Crodacel QL), hydroxypropylcellulose (HPC), and hydroxypropylmethylcellulose (HPMC), poly (acrylic acid), cyclodextrins, methyl acrylamido propyl triammonium chloride (M APT AC), polyethylene oxide, polyvinylpyroliddone, poly vinyl alcohol, and propylene oxide/ethylene oxide random copolymers. Poloxamers may also be used as additives. Examples include both the Pluronic^® polyols having an (P_ι)_a(P₂)_b(P_ι)_a structure such as Pluronic^® F38, L44, P65, F68, F88, L92, P103, P104, P105, F108, L122, and F127, as well as the reverse Pluronic^® R series (P₂)_a(P_ι)_b(P₂)_a strucmre such as Pluronic^® 17R2 and 25R8. Other miscellaneous materials include propyleneoxide, urea, triethanolamine, alkyphenol ethoxylates (Iconol series), and linear alcohol alkoxylates (Plurafac series).

Additives affect the viscosity of the compositions differently depending upon the nature of the additive and its concentration. Some additives will affect the initial or final viscosity, whereas others will affect the temperature range of the viscosity response, or both.

Potassium chloride and acetamide MEA are two examples of additives which decrease the final viscosity of the composition (see Example 30). KC1 (0.25%) added to a 1 wt% reversibly gelling polymer composition reduces the viscosity by about 3000 cps. See Figure 6. The humectant, acetamide MEA, lowers the viscosity of a 1 wt% solution by approximately 1, 500 cps (see Figure 7).

Glycerin, ethanol and dimethicone copolymer have been shown to affect the temperature range over which the viscosity response occurs. Glycerin shifts the transition temperature to a slightly lower range from an initial 24-34 °C to about 24- 30°C, but does not affect the final viscosity (see Example 44). The effect of ethanol on the viscosity is different at different concentration levels. At 5 wt% and 10 wt% added ethanol, the transition temperature is shifted to lower ranges, e.g., 14-19° C and 20- 29 °C, respectively. At 20 wt% added ethanol, the composition not only exhibits a lowering of the transition temperature, but also a marked increase in initial and final viscosity. See Figure 8. Dimethicone copolymer (1 wt%) also changed the transition temperature, but in this instance the transition temperature range was raised to 28- 41 °C. Thus, proper selection of additives permits the formulator to adjust the transition temperature to various ranges.

Those skilled in the art will appreciate that the polymer network compositions of the present invention may be utilized for a wide variety of cosmetic and personal care applications. To prepare a cosmetic composition, and effective amount of cosmetically active agent(s) which imparts the desirable cosmetic effect is incorporated into the reversibly gelling polymer network composition of the present invention. Preferably the selected agent is water soluble, which will readily lend itself to a homogeneous dispersion through out the reversibly gelling polymer network composition; however, the polymer network has been demonstrated to significantly solubilize or suspend hydrophilic agents in order to improve formulation homogeneity (see Example 36). It is also preferred that the agent(s) is nonreactive with the polymer network composition. For materials which are not water soluble, it is also withing the scope of the invention to disperse or suspend powders or oil (lipophilic materials) throughout the polymer network composition. It will also be appreciated that some applications may require a sterile environment. It is contemplated as within the scope of the invention that the reversibly gelling polymer network compositions of the present invention may be prepared under sterile conditions. An additional feature of the reversibly gelling polymer composition is that it is prepared from constiment polymers that have known accepted toxicological profiles.

The poloxamer:poly(acrylic acid) polymer network has been evaluated under Good Laboratory Practice (GLP) standard protocols known in the art for toxicity in animal models and found to exhibit no toxic effects. The results of the toxicity study are summarized in the following Table 1. The non-toxicity of the polymer network makes it an ideal candidate for use in cosmetic compositions.

Table 1. Toxicity data for 6% poloxamer:poly(acrylic acid) solution at pH 7.

Exemplary cosmetic and personal care applications, for which the reversibly gelling polymer network composition may be used include, but are not limited to, baby products, such as baby shampoos, lotions, powders and creams; bath preparations, such as bath oils, tablets and salts, bubble baths, bath fragrances and bath capsules; eye makeup preparations, such as eyebrow pencil, eyeliner, eye shadow, eye lotion, eye makeup remover and mascara; fragrance preparations, such as colognes and toilet waters, powders and sachets; noncoloring hair preparations, such as hair conditioner, hair spray, hair straighteners, permanent waves, rinses, shampoos, tonics, dressings and other grooming aids; color cosmetics; hair coloring preparations such as hair dye, hair tints, hair shampoos, hair color sprays, hair lighteners and hair bleaches; makeup preparations such as face powders, foundations, leg and body paints, lipstick, makeup bases, rouges and makeup fixatives; manicuring preparations such as basecoats and undercoats, cuticle softeners, nail creams and lotions, nail extenders, nail polish and enamel, and nail polish and enamel remover; oral hygiene products such as dentrifices and mouthwashes; personal cleanliness, such as bath soaps and detergents, deodorants, douches and feminine hygiene products; shaving preparations such as aftershave lotion, beard softeners, men's talcum, shaving cream, shaving soap and preshave lotions; skin care preparations such as cleansing preparations, skin antiseptics, depilatories, face and neck cleansers, body and hand cleansers, foot powders and sprays, moisturizers, night preparations, paste masks, and skin fresheners; and suntan preparations such as suntan creams, gels and lotions, indoor tanning preparations.

Preparation of the above-named cosmetic compositions and others may be accomplished with reference to any of the cosmetic formulation guidebooks and industry journals which are available in the cosmetic industry. These references supply standard formulations which may be modified by the addition or substitution of the reversible viscosifying polymer network of the present invention into the formulation. Suitable guidebooks include Cosmetics and Toiletries Magazine. Vo. I ll (March, 1996); Formulary: Ideas for Personal Care. Croda, Inc., Parsippany, NJ (1993); and Cosmeticon: Cosmetic Formulary. BASF, which are hereby incorporated in their entirety by reference.

The cosmetic composition may be in any form. Suitable forms include but are not limited to lotions, creams, sticks, roll-on formulations, mousses, aerosol sprays, pad-applied formulations, and film-forming formulations.

As those skilled in the art will appreciate, the foregoing list is exemplary only. Because the reversibly gelling polymer network composition of the present invention is suited for application under a variety of physiological conditions, a wide variety of cosmetically active agents may be incorporated into and administered from the polymer network composition. In addition to the poloxamer:poly(acrylic acid) polymer network, additional cosmetically acceptable carriers may be included in the composition, such as by way of example only, emollients, surfactant, humectants, powders and other solvents. By way of example only, the cosmetic composition also may include additional components, which serve to provide additional aspects of the cosmetic affect or to improve the stability and/or administration of the cosmetic. Such additional components include, but are not limited to, preservatives, abrasives, acidulents, antiacne agents, anti-aging agents, antibacterials, anticaking, anticaries agents, anticellulites, antidandruff, antifungal, anti-inflammatories, anti-irritants, antimicrobials, antioxidants, antiperspirants, antiseptics, antistatic agents, astringents, binders, buffers, additional carriers, chelators, cell stimulants, cleansing agents, conditioners, deodorants, depilatories, detergents, dispersants, emollients, emulsifiers, enzytnes, essential oils, exfoliants, fibers, film forming agents, fixatives, foaming agents, foam stabilizers, foam boosters, fungicides, gellants, glosser, hair conditioner, hair set resins, hair sheen agents, hair waving agents, humectants, lubricants, moisture barrier agents, moisturizers, ointment bases, opacifier, plasticizer, polish, polymers, powders, propellant, protein, refatting agents, sequestratnt, silicones, skin calming agents, skin cleansers, skin conditioners, skin healing, skin lightening agents, skin protectants, skin smoothing agents, skin softening agents, skin soothing agents, stabilizers, sunscreen agents, surfactants, suspending agents, tanning accelerators, thickeners, vitamins, waxes, wetting agents, liquefiers, colors, flavors and/or fragrances. Suitable materials which serve the additive functions listed here are well known in the cosmetic industry, a listing of the additive function and materials suitable for incorporation into the cosmetic composition may be found in Appendix A, which is appended hereto at the end of the specification. Further information may be obtained by reference to The Cosmetic Bench Handbook. Cosmetics & Toiletries, C.C. Urbano, editor, Allured Publ. Corp., 1996, which is hereby incorporated in its entirety by reference.

A brief description of some preferred additives and cosmetically active agents follows. The compositions of the invention include a safe and effective amount of a cosmetically active agent. "Safe and effective", as it is used herein, means an amount high enough to significantly positively modify the condition to be treated or the cosmetic effect to be obtained, but low enough to avoid serious side effects.

Preservative can be desirably incorporated into the cosmetic compositions of the invention to protect against the growth of potentially harmful microorganisms. Suitable preservatives include, but are not limited to, alkyl esters of parahydroxybenzoic acid, hydantoin derivatives, parabens, propioniate salts, triclosan tricarbanilide, tea tree oil, alcohols, farnesol, farnesol acetate, hexachlorophene and quaternary ammonium salts, such as benzolconjure, and a variety of zinc and aluminum salts. Cosmetic chemists are familiar with appropriate preservatives and may select that which provides the required product stability. Preservatives are preferably employed in amounts ranging from about 0.0001 % to 2% by weight of the composition.

Emollients can be desirably incorporated into the cosmetic compositions of the invention to provide lubricity to the formulation. Suitable emollients may be in the form of volatile and nonvolatile silicone oil, highly branched hydrocarbons and synthetic esters. Amounts of emollients may be in the range of about 0.1-30 wt%, and preferably about 1-20 wt%. By way of example only, suitable silicones include cyclic or linear polydimethylsiloxanes, polyalkylsiloxanes, polyalkylarylsiloxanes and polyether siloxanes. By way of example only, suitable ester emollients include alkenyl esters of fatty acids, polyhydric alcohols, such as ethyleneoxide mono and di-fatty acid esters, polyethyleneoxide and the like, ether-esters, such as fatty acid esters of ethoxylated fatty alcohols, wax esters, such as beeswax, spermaceti, mysristyl myristate and stearyl stearate, and sterol esters such as cholesterol fatty acids.

A variety of oily emollients may be employed in the compositions of this invention. These emolients may be selected from one or more of the following classes: 1. Triglyceride esters such as vegetable and animal fats and oils. Examples include castor oil, cocoa butter, safflower oil, cottonseed oil, corn oil, olive oil, cod liver oil, almond oil, avocado oil, palm oil, sesame oil, squalene, Kikui oil and soybean oil; 2. Acetoglyceride esters, such as acetylated monoglycerides; 3. Ethoxylated glycerides, such as ethoxylated glyceryl monostearate; 4. alkyl esters of fatty acids having 10 to 20 carbon atoms, such as, methyl, isopropyl, and butyl esters of fatty acids, and including hexyl laurate, isohexyl laurate, isohexyl palmitate, isopropyl palmitate, decyl oleate, isodecyl oleate, hexadecyl stearate, decyl stearate, isopropyl isostearate, diisopropyl adipate, diisohexyl adipate, dihexyldecyl adipate, diisopropyl sebacate, lauryl lactate, myristyl lactate, and cetyl lactate; 5. Alkenyl esters of fatty acids having 10 to 20 carbon atoms, such as oleyl myristate, oleyl stearate, and oleyl oleate and the like; 6. Fatty acids having 10 to 20 carbon atoms, such as pelargonic, lauric, myristic, palmitic, stearic, isostearic, hydroxystearic, oleic, linoleic, ricinoleic, arachidic, behenic, and erucic acids and the like; 7. Fatty alcohols having 10 to 20 carbon atoms, such as, lauryl, myristyl, cetyl, hexadecyl, stearyl, isostearyl, hydroxystearyl, oleyl, ricinoleyl, behenyl, erucyl, and 2-octyl dodecanyl alcohols are examples of satisfactory fatty alcohols and the like; 8. Fatty alcohol ethers, such as ethoxylated fatty alcohols of 10 to 20 carbon atoms including the lauryl, cetyl, stearyl, isostearyl, oleyl, and cholesterol alcohols, having attached thereto from 1 to 50 propylene oxide groups; 9. Ether-esters such as fatty acid esters of ethoxylated fatty alcohols; 10. lanolin and derivative, such as lanolin, lanolin oil, lanolin wax, lanolin alcohols, lanolin fatty acids, isopropyl lanolate, ethoxylated lanolin, ethoxylated lanolin alcohols, ethoxylated cholesterol, propoxylated lanolin alcohols, acetylated lanolin alcohols, lanolin alcohols linoleate, lanolin alcohols ricinoleate, acetate of lanolin alcohols ricinoleate, acetate of ethoxylated alcohols-esters, hydrogenolysis of lanolin, ethoxylated hydrogenated lanolin, ethoxylated sorbitol lanolin, and liquid and semisolid lanolin absorption bases and the like; 11. Polyhydric alcohol esters, such as, ethylene glycol mono and di-fatty acid esters, diethylene glycol mono- and di-fatty acid esters, polyethylene glycol (200- 6000) mono- and di-fatty acid ester, propylene glycol mono- and di-fatty acid esters, polypropylene glycol 2000 monooleate, polypropylene glycol 2000 monostearate, ethoxylated propylene glycol monostearate, glyceryl mono- and di-fatty acid esters, polyglycerol polyfatty esters, ethoxylated glyceryl monostearate, 1,2-butylene glycol monostearate, 1,2-butylene glycol distearate, polyoxyethylene polyol fatty acid ester, sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters are satisfactory polyhydric alcohol esters; 12. Was esters such as beeswax, spermaceti, myristyl myristate, stearyl stearate; 13. Beeswax derivatives, e.g., polyoxyethylene sorbitol beeswax; 14. Vegetable waxes including carnauba and candelilla waxes; 15. Phospholipids such as lecithin and derivatives; 16. Sterol including cholesterol and cholesterol fatty acid esters; 17. Amides such as fatty acid amides, ethoxylated fatty acid amides, solid fatty acid alkanolamides.

Humectants may be added to the composition to increase the effectiveness of the emollient, to reduce scaling, to stimulate removal of built-up scale and improve skin feel. By way of example only, suitable humectants include polyhydric alcohols, such a glycerol, polyalkylene glycols, alkylene polyols, their derivatives, propyleneoxide, dipropyleneoxide, polypropyleneoxide, polyethyleneoxide, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, 1,2,6-hexanetriol, ethoxylated glycerol, propøxylated glycerol and the like. The amount of humectant may be in the range of about 0.5-30 wt% and preferably between 1-15 wt% .

In topical skin care applications, a variety of active substances may be advantageously employed, by way of example, only suitable active agents which may be incorporated into the cosmetic composition include anti-aging active substances, anti-wrinkle active substances, hydrating or moisturizing or slimming active substances, depigmenting active substances, substances active against free radicals, anti-irritation active substances, sun protective active substances, anti-acne active substances, firming- up active substances, exfoliating active substances, emollient active substances, and active substances for the treating of skin disorders such as dermatitis and the like.

By way of example only, in the case of hydration, one or more moisturizers may be used, such as glycerin or urea, in combination with one or more precursor agents for the biosynthesis of structural proteins, such as hydroxyproline, collagen peptides, and the like.

By the way of example only, in case of slimming, at least on ketolytic agent or an alpha-hydroxyacid such as a salicylic acid or 5-n-octanoicsalicylic acid may be used in combination with at least one liporegulating agent such as caffeine.

By way of example only, in the case of depigmentation, at least one keratolytic agent is used in combination with a depigmenting agent such as hydroquinone, tyrosinasee inhibitor (kosic acid), kojic acid and sodium metabisulfite and the like.

By way of example only, in the case of protection against free radical agents, vitamin E (against CO₂ radicals), superoxide dismutase (against O₂ free radicals) and sugar and caffeine (against OH free radicals). By way of example only, in the case of anti-aging, moisturizers, sunscreens, alpha-hydroxyacids, salicylic acid or surface restructuring agents may be used in combination with enzymes for the repair of DNA, vascular protective agents or phospholipids rich in oligoelements and polyunsaturated fatty acids. By way of example only, in the case of anti-acne agents, keratolytics, such as salicylic acid, sulfur, lactic acid, glycolic, pyruvic acid, urea, resorcinol and N- acetylcysteine, and retinoids, such as retinoic acid and its derivatives may be used. By way of example only, in the case of anti-inflammation, non-steroidal anti- inflammatory agents (NSAIDS) may be used, such as propionic acid derivatives, acetic acid, fenamic acid derivatives, biphenylcarboxylic acid derivatives, oxicams, including but not limited to aspirin, acetaminophen, ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, and bucloxic acid and the like. By way of example only, in the case of antibiotic and antimicrobials may be included in the composition of the invention. Antimicrobial drugs preferred for inclusion in compositions of the present invention include salts of β-lactam drugs, quinolone drugs, ciprofioxacin, norfloxacin, tetracycline, erythromycin, amikacin, triclosan, doxycycline, capreomycin, chlorhexidine, chlortetracycline, oxy tetracycline, clindamycin, ethambutol, hexamidine isethionate, metronidazole, pentamidine, gentamicin, kanamycin, lineomycin, methacycline, methanamine, minocycline, neomycin, netilmicin, paromomycin, streptomycin, tobramycin, miconazole and amanfadine and the like.

By way of example only, in the case of sunscreen protection, suitable agents include 2-ethylhexyl p-methoxycinnamate, 2-ethylhexy N,N-dimethyl-p-aminobenzoate, p-aminobenzoic acid, 2-phenyl p-methoxycinnamate, 2-ethylhexyl octocrylene, oxybenzone, homomenthyl saliclate, octyl salicylate, 4,4'-methoxy-t- butyldibenzoylmethen, 4-isopropyl dibenzoylmethane, 3-benzylidene camphor, 3-(4-methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide, and mixtures thereof and the like. The sunscreening agents disclosed therein have, in a single molecule, two distinct chromophore moieties which exhibit different ultra-violet radiation absorption spectra. One of the chromophore moieties absorbs predominantly in the UVB radiation range and the other absorbs strongly in the UVA radiation range. These sunscreening agents provide higher efficacy, broader UV absorption, lower skin penetration and longer lasting efficacy relative to conventional sunscreens. Generally, the sunscreens can comprise from about 0.5% to about 20% of the compositions useful herein. Exact amounts will vary depending upon the sunscreen chosen and the desired Sun Protection Factor (SPF). SPF is a commonly used measure of photoprotection of a sunscreen against erythema. By way of example only, in the case of sunless tanning agents include, dihydroxy acetone, glyceraldehyde, indoles and their derivatives, and the like.

The composition may include cleansing surfactants. Cleansing surfactants are cationic, anionic, amphoteric or non-ionic surfactants which are water-soluble and produce a consumer-acceptable amount of foam. Non-ionic surfactants are well-known materials and have been used in cleansing compositions. Therefore, suitable non-ionic surfactants include, but are not limited to, compounds in the classes known as alkanolamides, block copolymers of ethylene and propylene, ethoxylated alcohols, ethoxylated alkylphenols, alkyl polyglycosides and mixtures thereof. In particular, the non- ionic surfactant can be an ethoxylated alkylphenol, i.e., a condensation product of an alkylphenol having an alkyl group containing from about 6 to about 12 carbon atoms in either a straight chain or branched chain configuration with ethylene oxide, the ethylene oxide being present in an amount equal to at least about 8 moles ethylene oxide per mole of alkylphenol. Examples of compounds of this typ include nonylphenol condensed with about 9.5 moles of ethylene oxide per mole of phenol; dodecylphenol condensed with about 12 moles of ethylene oxide per mole of phenol; dinonylphenol condensed with about 15 moles of ethylene oxide per mole of phenol; octylphenol condensed with about ten moles of ethylene oxide per mole of phenol; and diisooctyl phenol condensed with about 15 moles of ethylene oxide per mole of phenol. A wide variety of acids, bases, buffers, and sequestrants can be utilized to adjust and/or maintain the pH and ionic strength of the compositions useful in the instant invention. Materials useful for adjusting and/or maintaining the pH and/or the ionic strength include sodium carbonate, sodium hydroxide, hydrochloric acid, phosphoric acid, sulfuric acid, acetic acid, sodium acetate, sodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, sodium citrate, sodium bicarbonate, triethanolamine, EDTA, disodium EDTA, tetrasodium EDTA, and the like. The polymer network may be useful as a solubilization agent in cosmetic and personal care applications. A self-assembling system comprising the reversibly gelling polymer network exhibits thermogelation, pH sensitivity, and the ability to solubilize hydrophobic agents in aqueous media. When poloxamer is copolymerized with poly(acrylic acid) (PAA) according to the invention, the resulting copolymer network is bioadhesive and can be applied in a number of therapies. The materials described in this invention combine "reverse" thermoviscosification mucoadhesion, solubilization of hydrophobic and difficult to manage moieties, easy formulation, and protection of agents from degradation to provide a superior medium for cosmetic and personal care products.

The reversible viscosification of the polymer network at elevated temperatures makes the materials idea for use as thickening agents in cosmetic and personal care products at any temperature above the transition. Another use of the "thickening" of solutions containing the polymer network as a thickener supplement in emulsions. Currently, emulsifiers are often negatively affected by increased temperatures. An additive with reverse thermal viscosification properties, however, would react in exactly the opposite way, increasing its ability to emulsify as it gained three- dimensional strucmre upon heating above its transition temperature.

In the applications where the reversibly gelling polymer composition can act as a surfactant, the polymer network will have the ability to act as a primary emulsifier without any (or with very little) addition of traditional surfactant. The responsive polymer network will also act as a stabilizer for oil soluble ingredients that would conventionally need to be solubilized by oils in formulation. The hydrophobic portion of the polymer network (PPO) forms domains which act as reservoirs for an oil-soluble or hydrophobic additive, such as an oil droplet, as is illustrated in Figure 9. These two features of the material of the invention would enable it to be used as a base in a cosmetic formulation that would be non-greasy due to lack of oils, such as petrolatum and mineral oil. The increase in viscosity above the transition temperature adds strucmre and yield value to the water phase and results in a highly stable emulsion. Thus, poloxamer:poly(acrylic acid) polymer network compositions are valuable materials in the formulation of cosmetic and personal care products. In particular, they may be useful as rheology modifiers, provide a cushioning effect on the skin, offer barrier properties and controlled release of actives. In addition, the polymer composition may serve as a surfactant and is compatible with most ingredients used in the cosmetic industry.

The above properties of the poloxamer:poly(acrylic acid) polymer network provides a cosmetic composition that spreads evenly and smoothly and which leaves a lubricious feel to the skin. A sensory evaluation was conducted with seven random volunteers in order to determine the sensory effect of a cream formulation on the skin. An oil-free cosmetic formulation was prepared substantially as set forth in Example 33(b) and was compared to Nivea Oil Free, a product of Beiersdorf of Germany. Volunteers placed unmarked samples on the skin and evaluated the formulation based upon its feel and texture. The samples were rated on a scale of 1 (bad) to 5 (good). The oil-free cosmetic formulation of the present invention scored equally to the Nivea Oil Free moisturizing product. Both samples scored a 3.5 on the rating scale.

The observed thermal behavior of the reversibly gelling polymer network suggests that the increase in viscosity is due to aggregation of the hydrophobic portion of the poloxamer at the transition temperature which, because of bonding with the poly(acrylic acid) component, serve as temporary cross-links which physically bridge adjacent chains of poly(acrylic acid) to provide a viscous gel-like extended polymer structure. The aggregation process may be understood as occurring as shown in Figure 10, in which a backbone 20 represent poly(acrylic acid), a thin band 24 represents the hydrophobic poly(propylene) glycol region of the poloxamer and a thick band 26 represents the hydrophilic poly (ethylene glycol) region of the poloxamer. Below the transition temperature, the polymer network is randomly arranged, as is shown in Figure 10(a). At or above the transition temperature, the hydrophobic regions 24 associate to form aggregations or micelles 28, as is shown in Figure 10(b). The association increases the effective molecular weight of the polymer network composition with the corresponding increase in viscosity. A general method of making the poloxameπPAA polymer network compositions of the present invention comprises solubilization of the poloxamer in acrylic acid monomer, followed by polymerization of the monomer to PAA. Polymerization may be accomplished by addition of a polymerization initiator or by irradiation techniques. The initiator may be a free radical initiator, such as chemical free radical initiators and UV or gamma radiation initiators. Conventional free radical initiators may be used according to the invention, including, but in no way limited to ammonium persulfate, benzoin ethyl ether, benzyl peroxide, 1, 2'-azobis(2,4-dimethylpentanitrile) (Vazo 52) and azobisisobutyronitrile (AIBN). Initiation may also be accomplished using cationic or ionic initiators, many variations of this method will be apparent to one skilled in the art and are contemplated as within the scope of the invention. For example, the poloxamer component may be dissolved in an acrylic acid/water mixmre instead of pure monomer. It may be desirable to remove unreacted monomer and/or free poloxamer from the resultant polymer network. This may be accomplished using conventional techniques, such as, by way of example, dialysis or sohxlet extraction.

Without intending to be bound by a particular mechanism or strucmre, the following scheme represents a possible chemical mechanism for the formulation of the system here described. These mechanisms are presented by way of explanation and are no way limiting of the invention. It is contemplated that these or other mechanistic routes may in fact occur in the formation of the polymer network of the present invention. I. Initiation

RR → 2R« (1)

R- + CH₂=CHCOOH → RCH₂CH«COOH (2) II. Hydrogen Abstraction

R» + -OCHRCH₂O- → RH + -OCR«CH₂O-

(3) R» + -CH₂CH₂COOH- → RH + -CH₂CH»COOH (4) HI. Chain Transfer -CH₂CH»COOH + -OCH₂CRH- → -CH₂CH₂COOH + -OCH₂CR»- (5)

-OCH₂CR»O- + -CH₂CHCOOH → -OCH₂CRHO- + -CH₂CH»COOH (7)

IV. Propagation

RCH₂CH«COOH + CH₂=CHCOOH → RCH₂CHCOOHCH₂CH»COOH (8) V. Side Chain Branching Off AA Backbone

-CH₂CH«COOH- + CH₂=CHCOOH → -CH₂CH(CH₂CH»COOH)COOH (9)

VI. AA Branching Off Poloxamer Backbone

-OCH₂CR»O- + CH₂=CHCOOH → -OCH₂CR(CH₂CH«COOH)O- (10)

VII. Homogenous Termination 2 -CH₂CH»COOH → -CH₂CHCOOHCHCOOHCH₂-

(11)

VIII. Heterogenous Termination with Bonding of Pluronic to PAA -CH₂CH«COOH + -OCH₂C«RO- → -CH₂CH(-OCRCH₂O-)COOH

(12a)

The scheme for bonding of poloxamer to acrylic acid may involve initiation (Eq.

1), hydrogen abstraction from the propylene or ethylene moiety of the poloxamer (Eq.

3), and attachment to acrylic acid via addition across the unsamrated bond (Eq. 10).

Propagation (Eq. 8) leads to the final PAA. Alternatively, the mechanism may proceed by initiation according to Eqs. (1) and (2), propagation to form PAA (Eq. 8), a chain transfer reaction to generate a reactive poloxamer moiety (Eq. 5), followed by addition of the reactive poloxamer moiety to the unsamrated bond of acrylic acid (Eq. 10) and subsequent propagation of the PAA chain. Thus, the polymer network may include a plurality of poly (aery lie acid) units bounded to a single poloxamer unit, or alternatively, a plurality of poloxamer units bound to a single PAA backbone. Combinations of these alternatives are also a possibility.

Reverse phase polymerization may be used to prepare polymer network beads by dispersion of the poloxamer and acrylic acid monomer mixmre in a nonpolar solvent such as hexane or heptane. The aggregating polymer /monomer solution is dispersed with 'agitation in the nonpolar solvent in order to suspend droplets of the solution. Polymerization of the monomer is initiated by conventional means (i.e., addition of an initiator or irradiation) in order to polymerize the monomer and form responsive polymer network beads. See U.S.S.N. 08/276,532 filed July 18, 1995 and entitled "Useful Responsive Polymer Gel Beads" for further information on the preparation of polymer gel beads, herein incorporated by reference. Such a method may be particularly desirable to provide a heat sink for the heat generated in the exothermic polymerization reaction. The polymer network complexes and aqueous gelling solutions of the present invention may be understood with reference to the following examples, which are provided for the purposes of illustration and which are in no way limiting of the invention.

Example 1. This example describes the synthesis of a polymer network and an aqueous responsive polymer network solution prepared using a triblock polymer of poly (ethyleneoxide) and poly(propyleneoxide), Pluronic^® F27 polyol, and poly (acrylic acid). This example also characterizes the gelation and the physical properties of the resultant polymer network.

Synthesis. Block copolymer of poly(propyleneoxide) (PPO) and poly(ethyleneoxide) (PEO) having triad ABA strucmre (PEO)_A(PPO)_B(PEO)_A

(Pluronic^® F127 NF polyol, Poloxamer 407 NF polyol, where "F" means Flakes, "12" means 12X300=3600 - MW of the PPO section of the block copolymer, "7" PEO in the copolymer is 70 wt% , and nominal molecular weight is 12,600) from BASF (3.0 g) was dissolved in 3.0 g acrylic acid (Aldrich). This represents a substantially 1:1 weight ratio of Pluronic^® F127 polyol and poly (aery lie acid). The solution was deaerated by N₂ bubbling for 0.5 h and following addition of 100 ml of freshly prepared saturated solution of ammonium persulfate (Kodak) in deionized water was kept at 70° C for 16 h resulting in a transparent polymer.

Viscosity measurements. A known amount of the resultant polymer was suspended in 100 ml deionized water into which NaOH was added. Following swelling for 3 days while stirring, the pH of the resulting fine suspension was adjusted to 7. Samples of 15 ml each were taken, and pH in each vial was adjusted to desired value by addition of 1 M HC1 or NaOH. Samples were then kept overnight and their viscosities were measured at different temperatures using Brookfield viscometer using either an SC4-18 or an SC4-25 spindle.

A control experiment was done with a physical blend of Pluronic^® F127 polyol and poly(acrylic acid) (MW 450,000) available from Aldrich. Pluronic^® F127 polyol and poly (aery lie acid) were dissolved together in deionized water at 1 wt% total polymer concentration and the resultant solution was adjusted to pH 7, stirred and kept in refrigerator. The responsiveness of the polymer network composition and the physical blend to temperamre and pH is illustrated in figs. 1, 11, and 12. Figs. 1 and 2 clearly demonstrate that the synthetic route outlined above resulted in a polymer network system that is sensitive to pH and temperamre of the environment. Note that the liquid-gel transition is very sharp, occurring over a very small temperamre change of pH (see Figure 11). Figure 12 is a viscosity vs. temperamre graph comparing the gelling characteristics of the responsive polymer network composition and the physical blend. The blend prepared by physically mixing the triblock PEG/PPG/PEG polymer and poly(acrylic acid) did not exhibit viscosifying effect either as a function of temperamre or pH. It was generally observed that 0.5 - 5 wt% polymer network compositions made of Pluronic^® F127 polyol and poly (aery lie acid) viscosity at temperatures of around 30°C and higher if pH is adjusted to 6 or higher. The gelling effect was observed in polymer network compositions standing 3 months or longer. Repeated heating and cooling of responsive polymer network compositions did not cause deterioration of the polymer network or the gelling effect. Solutions of either Pluronic^® F127 polyol or poly(acrylic acid) (1-5 wt% in water, adjusted to pH 6 or higher) or physical blends of the two lacked the reverse thermal gelling effects found for polymer network compositions.

Example 2. this example describes a standard operating procedure for the manufacture of the reversible gelling polymer network. The procedure is based upon a 50 liter production. A NaOH solution was prepared by dissolving 131.8 g NaOH pellets in 131.8 mL DI water (50% solution). The NaOH was allowed to dissolve completely. The NaOH solution will be used to convert a percentage of the acrylic acid to sodium aery late in situ. Acrylic acid monomer (4 kg) is charged into a monomer feed tank and agitated at 250 rpm. NaOH is added slowly. The precipitate formed as the acrylic acid is neutralized to sodium acrylate is allowed to dissolve. Pluronic^® F 127 (3.5 kg) is slowly added to the monomer feed tank. Pluronic^® F127 is dissolved under continued agitation. Norpar 12 (a refined C-12 alkane) is added to the reaction vessel (37 L). The mixmre is agitated at 100 rpm. Stabilizer solution of Ganex V-126 is prepared in 2L Norpar 12 and added to the reactor under agitation.

A reaction vessel was degassed using a nitrogen sparge introduced from the bottom of reactor and was continued throughout the reaction. Initiator (13.63 g Lauryl peroxide and 4.23 g Vazo 52 in 0.7 kg acrylic acid monomer) is introduced into the monomer solution, the monomer solution was transferred to the reaction vessel.

Agitation was increased to 150 rpm. Nitrogen sparging continued for an additional 20 minutes, and then heating began, heating began at a rate of 0.5 -1.0°C/min up to 75°C. The reaction began to exotherm at about 45-50°C and is allowed to continue without cooling until a maximum is reached. It is then cooled to 75 °C using forced cooling. The reaction continued for 12 hours and was then cooled to 35 °C. The slurry was transferred into pails and the polymer beads were allowed to settle.

The slurry was filtered through Buchner Funnels with filter paper (11 μm pore size) until the bulk of the Norpar had been removed from the beads. The beads were washed three times with heptane. The filtered beads were transferred to a Pyrex drying tray and spread on the tray in a uniform layer. The beads were dried under vacuum for 4 hours at 40-50 °C. The dried beads were analyzed as follows.

Elemental analysis. The elemental analysis was performed by Quantitative Technologies, Inc., Whitehouse, NJ using a Perkin Elmer 2400 CHN Elemental Analyzer. Analysis provided C (52.49%), H (7.50%), N ( < 0.05%), the balance assumed to be oxygen (39.96%). Thermal Gravimetric Analysis (TGA). The TGA method was performed by Massachusetts Material Research, Inc., West Boylston, MA using a Dupont TGA model 295. The assay was run using a temperamre ramp from 30 to 500°C/min. The resolution for the system was set to 4 (1.0°C/min for all slope changes). The data was analyzed using the first derivative of the curve and using maxima and minima to mark transitions. The moisture content was also calculated in this manner. The first derivative yielded three maxima. The first transition (moisture) was 3.0% by weight, the second transition was 14.0% by weight, and the third was 67.02% by weight. Residue (15.98%) remained. Molecular weight determination by gel permeation chromatography (GPC). The molecular weight was determined by GPC on a Hewlet Packard 1100 Liquid Chromatography system with a Viscotech T60 Triple Detector system. Three Waters Ultrahydrogel columns, 1000, 500 and 250 Λ, were used for the separation. The mobile phase was 0.1 M NaNO₃ and 0.01 M K₂HPO₄ salt solution, pH adjusted with phosphoric acid to a pH of 8.0 ± 0.1. the flow rate for the separation was 0.9 mL/min. The column temperamre was maintained at 15 °C. The injection volume for the assay was 50 μL. A PEG molecular weight standard of 23,000 Daltons was used to align the detectors. The result for the assay were: M_n: 341,700 Daltons M_p: 1,607,000 Daltons

M_w: 2,996,000 Daltons Free poloxamer determination by GPC. The amount of free (unbound) poloxamer in the polymer matrix was determined using the above GPC method and comparing the poloxamer peaks to that of a standard poloxamer solution. The typical result is approximately 18-22% free poloxamer by weight.

The effect of both the bonded and non-bonded poloxamer on the gelation properties of the responsive polymer network has been determined by extraction of the non-bonded poloxamer from the material. Such extraction studies have established that the graft co-polymer alone exhibits the characteristic reverse thermal gelation of the composition; however, the presence of non-bonded poloxamer component modulates the gelation process. The non-bonded poloxamer component can affect the temperamre of transition (from liquid to gel) and the degree of transition and assists in a more controlled and reproducible transition.

Bound poloxamer determination by ethylene oxide (EQ) titration. The EO titration was performed as follows. A 5 gm sample of the product polymer was extracted in dichloroethane for three hours at reflux temperatures. The solid is removed and dried under a vacuum for 12 hours at room temperamre. The dry material is then analyzed using ASTM method D 2959-95, "Standard Test Method for Ethylene Oxide Content". The amount of EO in the sample is related to the amount of poloxamer bound to the polymer. The typical result is approximately 15% by weight of EO. The relative amount of free poloxamer may be varied dependent upon the relative proportions of starting materials and the method of polymerization. Although the residual solids presumably contain only poloxamer which is bounded to the poly(acrylic acid), i.e. , a graft co-polymer, the material still shows strong viscosification when it is neutralized and dissolved in water. However, the temperamre of viscosification is increased substantially and the degree of viscosification per gram of total solids is increased by removal of free poloxamer. Thus, the free poloxamer plays a role in modifying the extent and temperamre of viscosification. The poloxamer undergoes conformational changes and changes to the critical micelle concentration as a function of temperamre. The poloxamer will change from an open, non-aggregated form to a micellular, aggregated form with changes in temperamre.

Residual acrylic monomer determination by gas chromatography (GO. The residual acrylic acid monomer was determined by GC analysis using a Hewlet Packard GC 5890A, using a HP-FFDAP-TPA 10 m x 0.52 mm x 1 μm column. The sample was extracted and run in methanol. Using an internal standard ratio, the sample was compared to a one point calibration. The typical results for this assay were below 70 ppm acrylic acid monomer.

Residual Norpar solvent by GC. The residual Norpar in the sample was determined by GC using the above method and comparing the Norpar peaks to that of a standard. The typical results were below 1.5 wt% . UV-vis spectrum. Optical clarity data of UV-vis spectrophotometer was obtained. A 1.0% solution in water was prepared and measured at 420 ran. Transmittance (%) was typically greater than 90% .

Differential scanning calorimetry (DSC). The DSC was performed by Massachusetts Material Research, Inc., West Boylston, MA using a temperamre ramp from 30 to 350°C at 5°C/min. The resolution for the system was set to 4 (1.0°C/min for all slope changes). The assay yielded one endothermic event at 265 °C, typically 270 J/g.

Examples 3-9. These examples describe the synthesis of several reversible thermal gelling polymer networks prepared using a variety of poloxamers and poly(acrylic acid). The gelation and the physical properties of the resultant polymer network compositions are reported in Table 2.

Table 2

Example 10. The following example demonstrates the effect of hydrophilic/hydrophobic ratio on the gelling temperamre. Polymer network compositions were prepared from the following poloxamers shown in Table 3.

Table 3. Composition of Poloxamers Investigated.

Table 3 shows that in this series, the fraction of PEO is reduced when the molecular weight of the PPO block is kept constant. Linse (Macromol. 26:4437-4449 (1993)) report phase diagrams for these copolymers in water were calculated and it was shown that two-phase boundaries corresponding to the beginning of aggregation are almost unaffected by the molecular mass, given a constant PEO/PPO ratio, whereas these boundaries shifted to lower temperamre as the PEO content of the polymer is reduced at constant mass. The strong dependence of the PEO/PPO ratio is a consequence of the differing solubilities of PEO and PPO in water at the elevated temperatures. Thus, one would suppose that aggregation that causes viscosification in the responsive polymer network composition should shift to lower temperamre as PEO fraction decreases.

The poloxamer (3.0 g) was dissolved in 3.0 g acrylic acid. The solution was deaerated by N₂ bubbling for 20 min. and following addition of the 100: 1 of freshly prepared saturated solution of ammonium persulfate in deionized water was kept at 70 °C for 16 h resulting in a strong whitish polymer. A sample of the polymer obtained (0.4 g) was suspended in 40 ml deionized water into which NaOH was added. Suspended responsive polymer network particles were allowed to dissolve under constant stirring. The resulting 1 wt% polymer network solution were subjected to the viscosity measurement at shear rate of 132 or 13.2 sec¹ using a SC4-18 spindle. It can be seen from Figure 16 that, firstly, viscosity of the 1 wt% responsive polymer network solutions before viscosification (at 20-24°C) decreases in the series (PEO)₃₇(PPO)₅₆(PEO)₃₇(F103) > (PEO)₂₅(PPO)₅₆(PEO)₂₅(F104) > (PEO)₁₆(PPO)₅₆(PEO)₁₆(F105) and, secondly, the temperamre at which gelation shifts from about 45 °C for (PEO)₃₇(PPO)₅₆(PEO)₃₇ to about 35 °C for (PEO)₂₅(PPO)₅₆(PEO)₂₅ and (PEO)₁₆(PPO)₅₆(PEO)₁₆. Both results are in excellent agreement with the theory set forth in Linse.

Example 11. The following example is related to release of and active agent from a poloxamer:poly(acrylic acid) polymer network. Drug loading and kinetics of release of the protein hemoglobin from poloxamer:poly(acrylic acid) polymer network is described.

Synthesis. Pluronic^® F127 (3.0 g) was dissolved in 3.0 g acrylic acid. The solution was deaerated by N₂ bubbling for 0.5 h and following addition of 100 FI of freshly prepared samrated solution of ammonium persulfate (Kodak) in deionized water was kept at 70° C for 16 h resulting in a transparent polymer. The resultant responsive polymer network obtained (5 g) was suspended in 95 ml deionized water into which NaOH was added. The resulting suspension was allowed to swell for 7 days. Hemoglobin loading and release. A 5 wt% responsive polymer network composition (3 g) was allowed to swell for 16 h in 10 ml of 0.25 mg/ml solution of human hemoglobin (Sigma) in deionized water adjusted to pH 8. The resulting mixmre was well shaken and placed into the feed chambers of customized vertical, static, Franz-like diffusion cells made of Teflon. The feed and receiver chambers of the diffusion cells were separated by mesh screens (#2063). The receiver chamber was continuously stirred by a magnetic bar. The cells were allowed to equilibrate to either 25 or 37°C (in an oven). The feed and receiver phases consisted of 1 g of the hemoglobin-loaded responsive polymer network and 6 ml of phosphate-buffered saline (pH 7.4), respectively. In the control experiment, the feed phase was made of 1 g of 0.25 mg/ml hemoglobin solution. After the feed solution had been loaded into the cell, the kinetic time commenced. Samples of the receiver phase was withdrawn from time to time and their absorbance was measured spectrophotometrically at 400 nm. To calculate hemoglobin concentrations, corresponding calibration curves (absorbance in PBS versus hemoglobin concentration) were generated. The results of the kinetic experiment are presented in Figure 17. It can be seen that the rate of hemoglobin release from the polymer network was substantially lowered at 37 °C when compared to that at 25 °C, because of viscosity increase in the polymer network at elevated temperatures (see Figure 1). The protein released from the polymer network composition still retained its native strucmre, as was determined by comparison of UV- vis spectra of release hemoglobin and natural hemoglobin. Example 12. The following example is related to release of an active agent from a poloxamer:poly(acrylic acid) polymer network. Drug loading and kinetics of release of the protein lysozyme from a polymer network is reported.

Lysozyme loading and release. A 5 wt% responsive polymer network composition (3 g) was allowed to swell for 16 h in 10 ml of 1 mg/ml solution of chicken egg-white lysozyme (Sigma) and 1.5 mg/ml sodium dodecyl sulfate (Aldrich) in deionized water adjusted to pH 8.5. The resulting mixmre was well shaken and placed into the feed chambers of customized vertical, static, Franz-like diffusion cells made of Teflon. The feed and receiver chambers of the diffusion cells were separated by mesh screens (#2063). The receiver chamber was continuously stirred by a magnetic bar. The cells were allowed to equilibrate to either 25 or 37 °C (in an oven). The feed and receiver phases consisted of 1 g of the lysozyme-loaded responsive polymer network and 6 ml of phosphate-buffered saline (pH 7.4), respectively. In the control experiment, the feed phase was made of 1 g of 1 mg/ml lysozyme solution. After the feed solution had been loaded into the cell, the kinetic time commenced. Samples were withdrawn and their absorbance measured spectrophotometrically at 280 nm. A calibration curve was prepared for lysozyme concentration ranging from 0 mg/ml to 0.5 mg/ml in phosphate buffered saline. The results of the kinetic experiment are presented in Figure 18. It can be seen that the rate of lysozyme release from the responsive polymer network composition was substantially lowered at 37 °C when compared to that at 25 °C, because of viscosity increase in responsive polymer network at elevated temperatures (see Figure 1).

In order to demonstrate the retention of the enzymatic activity of lysozyme, the lysozyme released from the responsive polymer network composition was assayed using Micrococcus lysodeikticus cells and compared to that of original lysozyme. The enzymatic activity of lysozyme was the same, within the error of the assay (15%), as that of the original lysozyme. Control without lysozyme in presence of sodium dodecyl sulfate did not show any appreciable lysis of the cells.

Example 13. The following example is related to release of an active agent from a poloxamer:poly(acrylic acid) polymer network. Drug loading and kinetics of release of insulin from a responsive polymer network composition is reported.

Insulin loading and release. A 5 wt% responsive polymer network composition (3 g) was allowed to swell for 15 h in 10 ml of 5 mg/ml solution of bovine Zi -insulin (Sigma) in deionized water adjusted to pH 7. The resulting mixmre was well shaken and placed into the feed chambers of customized vertical, static, Franz-like diffusion cells made of Teflon. The feed and receiver chambers of the diffusion cells were separated by mesh screens (#2063). The receiver chamber was continuously stirred by a magnetic bar. the cells were allowed to equilibrate to either 25 or 37°C (in an oven). The feed and receiver phases consisted of 1 g of the insulin-loaded responsive polymer network and 6 ml of phosphate-buffered saline (pH 7.4), respectively. In the control experiment, the feed phase was made of 1 g of 5 mg/ml insulin solution. After the feed solution had been loaded into the cell, the timing commenced. Samples were withdrawn and their absorbance was measured spectrophotometrically at 280 nm. A calibration curve was prepared for insulin concentration ranging from 0 mg/ml to 1.25 mg/ml in phosphate buffered saline. The results of the kinetic experiment are presented in Figure 19. The rate of insulin release from responsive polymer network was substantially lowered at 37°C when compared to that at 25°C, because of viscosity increase in responsive polymer network at elevated temperatures (see Figure 1).

Example 14. This example demonstrates the preparation of a sterile reversibly gelling polymer network aqueous composition and the stability of the composition to sterilization. The polymer network is prepared as described in Example 1 , except that the composition is prepared at 2 wt% Pluronic^® F127 polyol/poly (acrylic acid). After dissolution of the 2 wt% polymer network in water, the viscosity is measured. The composition then is sterilized by autoclaving at 121 °C, 16 psi for 30 minutes. Viscosity is determined after sterilization. The corresponding curves for viscosity (a) before and (b) after sterilization are shown in Figure 20 and establish that minimal change in the viscosity profile of the material has occurred with sterilization.

Examples 15-30. These examples show additives which may be used to affect the transition temperamre overall viscosification of the polymer network composition. A 1 wt% polymer network was prepared in deionized water at pH 7 in which a variety of additives were included in the composition. The effect of the additive was determined by generation of a Brookfield viscosification curve. Results are reported in Table 4.

Table 4.

I = increase; D = decrease; and N = no change

Example 31. Because of the surfactant nature of the polymer network composition coupled with the gelation effect of the polymer network composition, it is possible to prepare formulations which are 100% water-based, but which are lubricous and thick.

Formulations including a nonionic surfactant formulation: An O/W (oil-in- water) emulsion was made by combining the following ingredients utilizing conventional mixing techniques:

Table 5.

Polowax available from Croda

Into a vessel equipped with a high efficiency homogenizer, the formula amount of all ingredients is added, water is added to 100% w/w and allowed to mix to homogeneity. This formulation contains a nonionic surfactant and gives an emulsion that is fluid at room temperamre but viscosifies above 32 °C.

Formulations including a cationic surfactant formulation: An O/W (oil-in- water) emulsion was made by combining the following ingredients utilizing conventional mixing techniques: Table 6.

'Incroquat Behenyl TMS available from Croda

Into a vessel equipped with a high efficiency homogenizer, the formula amount of all ingredients is added and allowed to mix to homogeneity. This formulation contains a cationic surfactant and gives an emulsion that is fluid at room temperamre but viscosifies above 32 °C.

Formulations including an anionic surfactant formulation: An O/W (oil-in- water) emulsion was made by combining the following ingredients utilizing conventional mixing techniques:

Table 7.

'Crodafos CES available from Croda

Into a vessel equipped with a high efficiency homogenizer, the formula amount of all ingredients is added, water is added to 100% w/w and allowed to mix to homogeneity. This formulation contains an anionic surfactant and gives an emulsion that is fluid at room temperamre but viscosifies above 32 °C.

Example 32. Acne Medication: An oil-free, clear, anti-acne treatment is made by combining the following ingredients utilizing conventional mixing techniques:

Table 8.

'Germaben^® II available from Sutton Laboratories

To one vessel, equipped with a Lightnin' Mixer with a 3 blade paddle prop, the full amount of USP Purified Water to 100% w/w is added. While maintaining the temperamre, with moderate to vigorous mixing, the formula amount of Disodium EDTA, Citric Acid, DL-Panthenol, Glycerin, Salicylic Acid, and Germaben^® II is added. These materials are allowed to dissolve at 50 °C. After dissolution, the vessel is then cooled to 20°C. To another vessel, equipped with a high efficiency homogenizer, the formula amount of responsive polymer network is added. The responsive polymer network vessel is than cooled to 4°C. After cooling, while vigorously homogenizing, the contents of the first vessel is added to the second vessel, and allowed to mix to homogeneity.

The composition displays a flowable clear jelly appearance with excellent spreadability and absorption characteristics at room temperamre, and after heating the formulation to 32°C, the composition thickens to a gel-like consistency. Example 33. (a) Oil-free Moisturizer (formulation I): An oil-free, lubricous moisturizer was made by combining the following ingredients utilizing conventional mixing techniques: Table 9.

'Germaben^® II available from Sutton Laboratories

The above ingredients were added and processed as described above for the acne composition. The composition displayed a flowable creamy lotion appearance with excellent emolliency, spreadability and absorption characteristics at room temperamre. After heating the formulation to above 26°C, the composition thickened to a gel-like consistency. The viscosity vs. temperamre curve is shown in Figure 21 and demonstrates that addition of adjuvants to the composition significantly enhances the responsive polymer network maximum viscosity ( > 900.000 cps). The use of the poloxamer:poly(acrylic acid) polymer network in the formulation also imparts a unique viscosification effect after application to the skin, which is not evident in typical commercial O/W emulsion formulations (See Figure 21b).

(b) Oil-free Moisturizer (formulation II): An oil-free, lubricous moisturizer was made by combining the following ingredients utilizing conventional mixing techniques:

Table 10.

The above ingredients were added and processed as described above for the acne composition. The composition displayed a flowable creamy lotion appearance with excellent emolliency, spreadability and absorption characteristics at room temperamre. After heating the formulation to above 26 °C, the composition thickened to a gel-like consistency. The addition of adjuvants to the composition significantly enhances the polymer network maximum viscosity.

Example 34. Sunscreen Lotion. An oil-free, lubricous sunscreen lotion was made by combining the following ingredients utilizing conventional mixing techniques:

Table 11.

Example 35. Facial mask. A face mask was made by combining the following ingredients utilizing conventional mixing techniques:

Table 12.

Example 36. Facial toner. A face mask was made by combining the following ingredients utilizing conventional mixing techniques:

Table 13.

Example 36. Solubilization studies of model hydrophobic agents in the poloxamer :poly(acrylic acid) polymer network: estradiol and progesterone. This example is presented to demonstrate the solubilization of a hydrophobic agent in the polymeric network. Progesterone and estradiol were used as the hydrophobic agents in this model solubilization study.

Acrylic acid (99%), fluorescein (98%), β-estradiol (98%), and progesterone (98%) were all obtained from Aldrich and used as received. Pluronic^® F127 NF was obtained from BASF. Poly (oxyethylene-b-oxypropylene-b-oxyethylene)-g-poly (acrylic acid) copolymers (responsive polymer network) were synthesized by free-radical polymerization of acrylic acid in the presence of poloxamer as described above. The polymer network copolymers discussed here were composed of about 1 : 1 ratio of PAA to poloxamer. The rheological properties of polymer network were assessed using LVDV-II + and RVDV-II+ Brookfield viscometers. The microscopic light scattering of 21 nm poly(styrene) latex particles in deionized water and 1 wt% reversibly gelling polymer network was measured using He-Ne laser as described previously (see Matsuo, E.S., Orkisz, M., Sun, S.-T., Li, Y., Tanaka, T., Macromolecules, 1994, 27, 6791). The solubility of fluorescein and hormones in aqueous solutions was measured by the equilibrium of excess solubilizate with the corresponding solution following removal of undissolved species by centrifugation and filtration. Hydrophobic agents were assayed spectrophotometrically at 240 (progesterone) or 280 nm (estradiol), or by using 70/30 w/w H₂SO₄/MeOH (Tsilifonis-Chafetz reagent). In vitro hormone release studies were conducted using thermostated, vertical Franz cells. Spunbonded polypropylene microfilters (micron retention, 15-20) were used as a membrane separating feed and receiver phases in Franz cells. The responsive polymer network, water, ethanol, and 20% PEG in water were observed to wet the membrane. The receiver solution consisted of 20 w% PEG in water (pH 7) and were stirred by magnetic bars. The feed phases composed of responsive polymer network were loaded with either estradiol or progesterone. Each hormone was dissolved in ethanol and the resulting solution was added into the responsive polymer network.

Equilibrium solubility vs. temperamre plots for estradiol and progesterone (partition coefficient octanol/water (P) 7200 and 5888, respectively), in aqueous solutions of Pluronic^® F127 polyol and responsive polymer network are presented in Figure 22. It can be seen that increasing temperamre and concentration (C) of polymers in the solution raises the amount of the hormone dissolved. In Figure 22a, vertical lines represent critical micellar temperatures (CMT) for corresponding Pluronic^® F127 polyol solutions. It is interesting to note that the slope of the solubility-temperature plots increased as temperamre reached CMT, indicating that solubilization in the Pluronic^® solutions was predominantly due to the formation of micelles. Similar trend was observed in the responsive polymer network solutions. The S values in 5% aqueous solutions of branched PAA did not exceed 15 and 40 μg/mL at 60 °C for estradiol and progesterone, respectively. The solubility values found for responsive polymer network were the same as S in parent Pluronic^® solutions of equivalent concentrations. Therefore, it may be suggested that solubilization behaviors of the responsive polymer network are governed by the properties of the poloxamer incorporated into it. Thermodynamic parameters of the solubilization process with responsive polymer network were calculated using the same approximations as in the micellar solubilization with Pluronic^® polyols. See, Saito, Y., Kondo, Y., Abe, M., Sato, T., Chem. Pharm. Bull., 1994, 42, 1348. Namely, partition coefficient P was estimated from equilibrium solubilities of estradiol in responsive polymer network and water:

P=S_SH/S_W (13) by extrapolating the solubility plots of the steroid in Figure 22 to 100% responsive polymer network. Using P values obtained from data in Figure 23, we calculated the standard free energy change (ΔG), standard enthalpy of solubilization (ΔH), and standard entropy of solubilization (ΔS) using the following expressions:

ΔG = -RTlnP; ΔH = -R ΔlnP/Δ(l/T); ΔS = (ΔH - ΔG)/T (14)

Thermodynamic parameters obtained along with P values are given in Table 14. Apparent partition coefficients and thermodynamic parameters for solubilization of estradiol by responsive polymer network.

Table 14.

Negative ΔG values indicate spontaneous solubilization at all temperatures, whereas positive ΔH shows that the solubilization was endothermic, similar to the solubilization of estriol, as well as indomethacin, by the poloxamer. Notably, ΔS of solubilization was always positive, suggesting that the more ordered water molecules surrounding hydrophobic estradiol molecules moved to the less ordered bulk phase when the estradiol was transferred to the hydrophobic core of PPG segments in responsive polymer network. The aggregation of the PPG segments at elevated temperatures provides not only temporary cross-linking in the gel, but also a thermodynamically "friendly" environment for the hydrophobic drugs. Indeed, one can express the free energy of formation of the aggregate core-water interface in responsive polymer network as:

ΔG = [σP_w(l-φ) + σW_D φ](4πR²/n) (15) where σP_w and σW_D are the interfacial tensions between pure PPO polymer and water and between water and the drug, respectively; φ is the volume fraction of the drug within the PPO core; R is the effective radius of the core; and n is the aggregation number.

Equation (3) shows that solubilization of a hydrophobic drug of high σW_D should increase the stability of the aggregate. The solubilization process was found to decrease the critical micellization concentration and substantially increase the micellar core radius in Pluronic surfactants (Hurter, P.N., et al., "In Solubilization in Surfactant Aggregates", Christian, S.D., Ed., Marcel Dekker, New York, 1995). A similar trend is indicated by the lowering the onset of gelation of the responsive polymer network upon solubilization of fluorescein (LogP 2.1) (Figure 24). The solubilization of hydrophobic drugs by responsive polymer network, analogous to the micellar solubilization of drugs by poloxamer, suggests that the responsive polymer network can be an effective vehicle in drug delivery.

Our in vitro study of hormone release from responsive polymer network shows an increase in the initial transport rate with either decreasing total polymer concentration in the formulation or decreasing temperamre (Figure 25). These effects are related to the changes in macroscopic viscosity of the responsive polymer network, which erodes more rapidly from the feed phase through the membrane into the receiver compartment as the viscosity decreases (Figure 26). The degree of the responsive polymer network erosion was measured by weighing hormone-loaded responsive polymer network before and after kinetic experiment. Figure 27 shows that the relative amount of progesterone penetrating into the receiver phase decreased 4-fold with the increase of total polymer concentration, whereas the total relative amount of progesterone stayed almost constant as total polymer concentration in the responsive polymer network increased. This result shows the existence of two routes of transport of hydrophobic drugs in our model system. Firstly, the drug incorporated into aggregates within the responsive polymer network system can flow through the membrane along with the erosion of the responsive polymer network; secondly, the drug not associated with the responsive polymer network aggregates can diffuse out of the responsive polymer network in the feed phase. The second process should not be related to the viscosity of the responsive polymer network. Indeed, the dynamic light scattering experiment shows no dramatic change of diffusivity of poly(styrene) latex particles in the responsive polymer network as temperamre rises thereby increasing macroscopic viscosity more than 10-fold (Figure 28). This result indicates that the viscosity of the responsive polymer network is essentially unaffected on the microscopic scale.

Appendix A attached.

APPENDIX A FUNCTION DEFINITIONS

Abrasive: abrades, smoothes, polishes Buffer: helps maintain original pH (acidity or basicity) of a preparation

Absorbent powder: takes up liquids, sponge-like action Carrier: a vehicle or base used for a preparation

Absorption base: formes water-in-oil emulsions Chelate: form a complex with trace-metal impurities, usually calcium or iron

Acidulent: acidifies, lowers pH, neutralizes alkalis Colorant: adds color, may be a soluble dy or an insoluble pigment

Amphoteric: capable of reacting chemically either as an acid or a base; amphoteric Conditioner: improves condition of skin and hair surfactants are compatible with anionic and

Coupling agent: aids in solubilization or cationic surfactants emulsification of incompatible componenets

Analgesic: relieves pain

Decolorant: removes color by adsorption,

Antacid: neutralizes stomach acidity bleaching or oxidaion Antibacterial: destroys/inhibits the growth/ Denaturant: used to denature ethyl alcohol reproduction of bacteria

Dental powder: powdered dentifrice

Anti-caking: prevents or retards caking of

Deodorant: destroys, masks, or inhibits powders; keeps powders free-flowing formation of unpleasant odors

Anti-dandruff: retards or eliminates dandruff

Depilatory: removes hair chemically Antifoam: suppresses foam during mixing

Detergent: a surface-active agent (surfactant) that

Anti-inflammatory: reduces, suppresses, cleans by emulsifying oils and suspends counteracts inflamation paniculate soil

Anti-irritant: reduces, suppresses or prevents Disinfectant: destroys pathogenic irritation microorganisms Antimicrobial: destroys, inhibits or suppresses Dispersant: promotes the formation and the growth of microorganisms stabilization of a dispersion or suspension

Antioxidant: inhibits oxidation and rancidity Dye stabilizer: see Stabilizer

Antiperspirant: reduces or inhibits perspiration Emollient: softens, smoothes skin

Antipruritic: reduces or prevents itching Emulsifier: a surface-active agent (surfactant) that promotes the formation of water-in-oil Antiseptic: inhibits the growth of or oil-in-water emulsions microorganisms on the skin or on living tissue Enzymes: complex proteins produced by living cells that catalyze biochemical reactions at

Antistat: reduces static by neutralizing electrical body temperature. charge on a surface

Fiber: strands of natural or synthetic polymers; Astringent: contracts organic tissue after for instance, cotton, wool, silk, nylon, application polyester

Binder: promotes cohesion of powders

Film former: solution of a polymer that forms

Bleaching agent: lightens color, oxidizing agent films when the solvent evaporates after application to a surface

Botanical: natural plant derivative Fixative: fixes or sets perfumes; retards agent and re-establishes the disulfide evaporation; promotes longer lasting aroma linkages in hair

Flavor: imparts a characteristic taste (and aroma) Oil absorbent: see Absorbent powder to edible foods and drinks; sometimes used

Ointment base: an anhydrous mixture of in lip products oleaginous components used as a vehicle for

Foam booster: enhances quality and quantity of medicments lather of shampoos

Opacifier: opacfies clear liquids or solids

Foamer: a surface-active agent (surfactant) that

Oxidant: oxidizing agent, neutralizes reducing produces foam; an emulsion of air-in-water agents, bleaching agent Foam stabilizer: see Foam booster

Pearlant: imparts a pearlescent texture and luster

Fungicide: inhibits or destroys growth of fungi

Perfume solvent: see Solvent and Solubilizer

Gellant: a gelling agent; forms gels; includes a

Peroxide stabilizer: see Stabilizer wide variety of materials such as polymers, clays and soaps Pigment: a finely powdered insoluble substance used to impart color, luster, or opacity Glosser: furnishes a surface luster or brightness; usually used in lip or hair products Plasticizer: plasticizes (makes more flexible) polymeric films or fibers

Hair colorant: see Colorant

Polish: smoothes; adds gloss and luster

Hair conditioner: see Conditioner

Polymer: a very high molecular weight

Hair dye: imparts a new permanent or semi- compound consisting of repeating structural permanent color to hair units

Hair-set polymer: polymer and/or resins used to

Powder: a solid in the form of fine particles maintain desired hair shape

Preservative: protects products from spoilage by

Hair-set resin: se Hair-set polymer microorganisms

Hair waving: see Reducing agent and

Propellant: pressurized gas in a container used Neutralizer to expel the contents when pressure is

Humectant: absorbs, holds, and retains moisture released by opening a valve

Hydrotrope: enhances water solubility Protein: naturally occurring complex combinations of amino acids

Intermediate: basic chemicals which are chemically modified to obtain the desired Reducing agent: reduces a chemical compound function usually by donating electrons; neutralizes oxidizing agents

Lathering agent: a surface active agent

(surfactant) that forms a foam or lather on Refatting agent: adds oils materials to the mixing with air in solution; see also Foamer surface of substrates, e.g., skin and hair

Lubricant: reduces friction, smoothes, adds slip Resin: nonvolatile solid or semisolid organic substances obtained from plants as exudates Moisture barrier: retards passage of moisture or to prepared by polymerization of simple water molecules

Moisturizer: aids in increasing the moisture

Sequestrant: forms coordination complexes with content of the skin through humectant or multivalent positive ions barrier action

Silicone: polymeric organic silicon compounds Neutralizer: an oxidizing agent used in hair which are water-resistant waving that stops the action of the reducing Skin protectant: protects the skin from products are mainly high-molecular-weight environmental hydrocarbons

Solubilizer: solubilizes, usually into aqueous Wetting agent: a surface-active agent vehicles, normally insoluble materials, such (surfactant) that lowers the surface and as fragrances, flavors, oils, etc. interfacial tension, facilitating the wetting of surfaces

Solvent: usually liquids capable of dissolving other substances

Stabilizer: addedto stabilize emulsions and/or suspensions Stimulant: produces a temporary increase in the functional activity of an organism or any of its parts

Surfactant (surface active agent): lowers surface tension between two or more incompatible phases; soaps, detergents, wetting agents, solubilizing agents and emulsifying agents are typical surfactants; surfactants are classified as anionic, cationic, nonionic and amphoteric; anionic surfactants are negatively charged, cationic surfactants have no electrical charge

Suspending agent: keeps finely divided solid particles in suspension

Sweetener: sweetens to provide a more pleasant taste

Tanning accelerator: accelerates the tanning of skin

Thickener: thickens or increases viscosity/ consistency Thixotrope: the property of certain gels and emulsions of becoming more fluid or less viscous when shaken or stirred

UV absorber: used as a sunscreen and to protect preparations from degradation by UV radiation

UVA absorber: absorbs in the range 320- 400 nanometers (nm)

UVB abosrber: absorbs in the range 290- 320 nanometers (nm) Wax: any of numerous substances of plant, animal or synthetic origin that contain principally esters of higher fatty acids and higher fatty alcohols; free fatty alcohols, fatty acids and hydrocarbons may also be present; waxes derived from petroleum FUNCTIONS

Abrasive AHA

Adzuki beans Apple (Pyrus malus) extract Almond (Prunus amygdalus) meal, shell granules Apricot (Prunus armeniaca) kernel powder

Aluminum silicate Citric acid

Apricot (Prunus armeniaca) kernel powder, shells Ethyl lactate

Hydrated silica Glycolic acid

Jojoba (Buxux chinensis) seed powder Lactic acid Luffa cylindrica Malic acid

Olive stone granules Sodium lactate

Oyster shell powder Tartaric acid

Peach (Prunus persica) pit powder

Peach (Prunus persica) stone granules Antiacne Polyethylene Clays (white, yellow, red, green, pink)

Polyethylene HEC granules Perfluorodecalin

Polyethylene oxidized, P. spheres Salicylic acid

Polystyrene Sulfur

Pumice Rice (Oryza sativa) bran Anti-aging

Silica and S. colloidal Basil (Ocimum basilicum) extract

Sodium chloride Carrot (Daucus carota) extract

Walnut (Juglans regia) shell powder Catalpa kaempfera extract

Ceramide 33 (liquid soy extract) Absorption base Crataegus cuneata extract

1,2,6-Hexanetriol Eugenia jambolana extract Kaolin Fomes fometarius extract Petrolatum Fomistopsis pinicola extract

Rice (Oryza sativa) starch Ganoderma lucidum oil Soy (Glycine soja) sterol Ginseng (Panax ginseng) extract Zeolite Hyaluronic acid

Hydrolyzed serum protein

Absorbent powder Hydrolyzed soy flour

Corn (Zea mays) starch Isachne pulchella extract Maltodextrin Lactoferrin Nylon-12 Lady's Thistle (Silybum marianum) extract

Oat (Avena sativa) bran, flour, meal Ligusticum jeholense extract Zeolite Marine collagen

Mushroom (Coriolus versicolor) extract Acidulent Must rose (Rosa moschata) oil

Acetic acid Perfluorodecalin

Citric acid Quaternium-51

Fumaric acid Rubus thunbergii extract

Glutamic acid Serum protein Glycolic acid Stenocalyx micalii extract

Hydrochloric acid Tricholoma matsutake extract

Lactic acid

Nitric acid Antibacterial

Phosphoric acid Ammonium iodide Sodium bisulfate Chlorhexidine

Sulfuric acid Chlorhexidine diacetate, C. digluconate

Tartaric acid Chlorhexidine dihydrochloride Chlorphenesin Antidandruff

Hexamidine diisethionate Burdock (Arctium lappa) extract

He^'x tidine Chloroxylenol

Iceland moss (Cetraria islandica) extract Corydalis ambigua extract Lactoterrin Disodium undecylenamido MEA-sulfosuccinate

Lauralkonium bromide, L. chloride Ginger root extract

Laurtrimonium chloride Inga edulis extract

Laurylpyridinium chloride Mauritiella armata extract

Maurtiella armata extract Myristalkonium saccharinate Mushroom (Cordyceps sbolifera) extract

Orange blossom extract PEG-6 undecylenate

Orange (Citrus aurantium dulcis) peel extract Piroctone olamine

PEG-42 Ebiriko ceramides extract Resorcinol

Peppermint (Mentha piperita) extract Rosemary (Rosmarinus officinalis) extract Philodendron (Phellodendron amurense) extract Sodium shale oil sulfonate

Pine (Pinus sylvestris) needle extract Stenocalyx micalii extract

Polymethoxy bicyclic oxazolidine Undecylenamide DEA

Quaternium 73 Willow (Salix alba) bark extract

Rubus thunbergii extract Zinc pyrithione Tea tree (Melaleuca alternifolia) oil

Triclocarban Antifungal

Undecylenic acid Black walnut (Juglans nigra) extract) Coneflower (Echinacea angustifolia) extract

Anticaking Orange blossom extract Aluminum starch octenylsuccinate Pfaffia paniculata extract

Calcium stearate

Distarch phosphate Anti-inflammatorv

Hydrated silica Allantoin polygalacturonic acid

Kaolin Bisabolol Magnesium myristate, M. silicate Black poplar (Populus nigra) extract

Polyethylene, micronized Brassica rapa-depressa extract

Silica silylate Butcherbroom (Ruscus aculeatus) extract

Sodium aluminum silicate Calendula officinalis extract

Zinc stearate Catalpa kaempfera extract

Celastrus paniculata extract

Anticaries agent Ceramide 33 (liquid soy extract)

Cetylamine hydrofluoride Chaparral (Larrea mexicana) extract

Olaflur Coneflower (Echinacea angustifolia) extract

Sodium fluoride Cornflower (Centaurea cyanus) extract Stearyl trihydroxyethyl propylenediamine Dipotassium glycyrrhizinate dihydrofluoride Euphotorium fortunei extract

Duphrasia officinalis extract

Anticellulite Ficus racemosa extract

Aminophylline Golden seal (Hydrastis canadensis) root extract Bladderwrack (Fucus vesiculosus) extract Guaiazulene

Butcherbroom (Ruscus aculeatus) extract Horse chestnut (Aesculia hippocastanum) extract

Carcinia cambogia extract Jujube (Zizyphus jujuba) extract

Fomes fometarius extract Laminaria japonica extract

Fomistopsis pinicola extract Licorice (glycyrrhiza glabra) extract Ivy extrcy Ligusticum jeholense, L, lucidum extract

Mushroom (Coriolus versicolor) extract Matricaria (Chamomilla recutita) extract

TEA-hydroiodide Melaleuca uncinata extract

Tricholoma matsutake extract Melia azadirachta extract Mulberry (Morus nigra) extract PVP

Niacinamide ascorbate Saccharomyces lysate extract

Orange (Citrus aurantium dulcis) peel extract Sodium C12-15 pareth-15 sulfonate

Orange blossom extract Sodium lauroamphoacetate Palmetto extract Soy (Glycine soja) protein

Palmitoyl collagen amino acids Undecylenoyl collagen amino acids

Passion flower (Passiflora laurifolia) fruit extract Valerian (Valeriana officinalis) extract

Paulownia imperialis extract

Alicylic acid Antimicrobial Shea butter (Butyrospermum parkii) Benzalkonium chloride

Sodium carboxymethyl beta-glucan Benzoic acid soy (Glycine soja) protein Benzyl alcohol

Stearyl glycyrrhetinate Bromochlorophene

Stenocalyx micalii extract 2-Bromo-2-nitropropane- 1 ,3-diol Tocopheryl acetate, T. nicotinate Butylparaben

Trichomonas japonica extract Capryloyl collgen amino acids

Willow (Salix alba) extract Capryloyl glycine, C. keratin amino acids

Witch hazel (Hamamelis virginiana) extract Captan withania somniferum extract Cetethyldimonium bromide Yarrow (Achillea millefolium) extract Cetyl pyridinium chloride

Zinc lactate Chlorothymol

Chloroxylenol

Anti-irritant Citron oil

Acetyl monoethanolamine Copper PCA Allantoin Dichlorobenzyl alcohol

Allantoin acetyl methionine, A. glycyrrhetinic Dilauryldimonium chloride acid Domiphen bromide

Azelamide MEA Ethylparaben

Betaine Eucalyptus (Eucalyptus globulus) extract Calendula officinalis extract Fennel (Foeniculum vulgare) extract

Cocamidopropyl betaine Garlic (allium sativum) extract

Coceth-7 carboxylic acid Glyceryl caprylate, G. laurate

Cornflower (Centaurea cyanus) extract Hexamidine diisethionate

Diisostearyl dimer dilinoleate Hinokitiol Dipalmitoyl cystine Honeysuckle (Lonicera caprifolium) extract

Green tea extract Lichen (Usnea barbata) extract

Hydrolyzed sweet almond protein Myristalkonium chloride

Hydroxypropyltrimonium gleatin Pentylene glycol

Lauroyl collagen amino acids Phenethyl alcohol 1 -Lysine lauroyl methionine Phenol

Mallow extract Phenoxyethanol

Matricaria (Chamomilla recutita) extract Phenoxyisopropanol

Palmitoyl hydrolyzed milk protein Phenyl mercuric acetate, P.m. benzoate, P.m.

Palmitoyl hydrolyzed wheat protein borate Palmitoyl keratin amino acids o-Phenylphenol

PEG- 12 palm kernel glycerides Polymethoxy bicyclic oxazolidine

PEG-28 glyceryl tailowate Potassium sorbat

PEG-30 glyceryl monococoate Propylparaben

PEG-60 almond glycerides Ricinoleamodopropyltrimonium ethosulfate PEG-78 glyceryl cocoate Sage (Salvia officinalis) extract

PEG-82 glyceryl tailowate Sodium benzoate, S. pyrithione

PEG-200 glyceryl tailowate Sodium ricinoleate, S. shale oil sulfonate

Propionyl collagen amino acids Thimerosal Thyme (Thymus vulgaris) extract Tocopheryl acetate, T. linoleate Thymol Wild marjoram (Origanum vulgare) extract Triclo'carban Yeast (Saccheromyces cerevisiae) extract (Faex) Triclosan Undecylenamidopropyltrimonium methosulfate Antiperspirant Undecylenic acid Allantoin-aluminum chlorhydrate Zinc oxide, Z. PC A Aluminum capryloyl hydrolyzed collage Zinc pyrithione, Z. undecylenate Aluminum chlorhydrex-gly, A. chloride Aluminum chlorohydrate, A. chlorohydrex Antioxidant Aluminum PCA, A. sesquichlorohydrate

Ascorbic acid Aluminum undecylenoyl collagen amino acids

A. polypeptide Aluminum zirconium pentachlorhydrate

Ascorbyl oleate, A. palmitate Aluminum zirconium tetrachlorohydrate

Beta-carotene Aluminum zirconium tetrachlorohydrex GLY BHA Aluminum zirconium trichlorohydrate

BHT Aluminum-zirconium-glycine powder t-Butyl hydroquinone Sage (Salvia officinalis) extract

Dilauryl thiodipropionate Tormentil (Potentilla erecta) extract

Dimyristyl thiodipropionate Zirconium chlorohydrate Disodium EDTA

Distearyl thiodipropionate Antiseptic

Dodecyl gallate Aluminum PCA

EDTA Azadirachta indica extract

Erythorbic acid 2-Bromo-2-nitropropane- 1 ,3-diol Ferulic acid Calendula amurrensis extract

Grape (Vitis vinifera) seed extract p-Chloro-m-cresol

Green tea extract Clove (Eugenia caryophyllus) oil

HEDTA Crataegus cuneata extract

Hydroquinone Dichlorobenzyl alcohol Hydroquinone-beta-D-glucopyranoside Entada phaseoloides extract p-Hydroxyanisole Eucalyptus (Eucalyptus globulus) extract

Lactoferrin Golden seal (Hydrastis canadensis) root extract

Lysine PCA Hexachlorophene

Melanin Melia australasica, M. azadirachta extract Methyl gallate Methyl salicylate

Niacinamide ascorbate Orange (citrus aurantium dulcis) peel extract

Nordihydroguaiaretic acid Oxyquinoline sulfate

Oat (Avena sativa) extract Pfaffia paniculata extract

Oryzanol Potassium abietoyl hydrolyzed collagen Pentasodium pentetate PVP-iodine

Pentetic acid Silver nitrate

Propyl gallate Sodium salicylate

Retinyl palmitate polypeptide Sterculia platanifolia extract

Rosemary (Rosmarinus officinalis) extract Tea tree (Melaleuca alternifolia) oil Saccharomyces lysate extract Tormentil (Potentilla erecta) extract

Sage (Salvia officinalis) extract Xanthozylum bungeanum extract

Sodium ascorbate, S. erythorbate

Sodium metabisulfite Antistat

Sodium selenate, S. sulfite Acetamide MEA Superoxide dismutase, Acetamidopropyl trimonium chloride

Tea (Camillia sinensis) extract 6-(N-Acetylamino)-4-oxyhexyltrimonium

Tetrasodium EDTA chloride

Tocopherol Alkyl dimethyl betaine Babassuamidopropalkonium chloride Soyethyldimonium ethosulfate

Behenamidopropyl ethyldimonium ethosulfate Stearalkonium chloride

Beherfamidopropyl hydroxyethyl dimonium Stearamidopropyl benzyl dimonium chloride chloride Stearamidopropyl ethyldimonium ethosulfate Carboxymethyl chitin Steartrimonium chloride

Cetethyl morpholinium ethosulfate N-Stearyl-(3-amidopropyl)-N,N-dimethyl-N-ethyl

Cetrimonium chloride ammonium ethyl sulfate

Chitin Wheat germamidopropylethyldimonium

Chitosan ethosulfate Cocamidopropyl ethyldimonium ethosulfate

Cocodimonium hydroxypropyl hydrolyzed rice Astringent protein Aluminum citrate, A. lactate

Cocodimonium hydroxypropyl hydrolyzed soy Astragalus sinicus extract protein Astrocaryum murumuru, A. tucuma extract Dimethicone hydroxypropyl trimonium chloride Azadirachta indica extract dimethyl behenamine, D. cocamine Azelamide MEA

Dimethyl palmitamine, D. soyamine Bearberry (Arctostaphylos uva-ursi) extract

Dimethyl tailowamine Birch (Betula alba) leaf extract

Dioleylamidoethyl hydroxyethylmonium Catalpa kaempfera extract methosulfate Celastrus paniculata extract

Dipalmitoylethyl hydroxyethylmonium Coccinea indica extract methosulfate Coffee (Coffea arabica) bean extract

N-Dodecy 1-N , N-dimethyl-N-(dodecy 1 acetate) Euphrasia officinalis extract ammonium chloride Euterpe precatoria extract Erucamidopropyl hydroxysultaine Evening primrose (Oenothera biennis) extract

Glyceryl monopyroglutamate Gentian (Gentiana lutea) extract

Hydrogenated tailowamine oxide Geranium maculatum extract

Isosteara propyl dimethylamine Grape (Vitis vinifera) leaf extract

Lactamidopropyl trimonium chloride Henna (Lawsonia inermis) extract Lauryldimonium hydroxypropyl hydrolyzed Hierochloe odorata extract collagen Honeysuckle (Lonicera caprifolium) extract

Linoleamidopropyl dimethylamine dimer Hops (Humulus lupulus) extract dilinoleate Horesetail extract

Olealkonium chloride Hypericum perforatum extract PEG-2 cocamine Ivy extract

PEG-2 cocomonium chloride Juniperus communis extract

PEG-2 oleammonium chloride Kadsura heteliloca extract

PEG-8 caprylic/capric glycerides Kola (Cola acuminata) extract

PEG- 10 cocamine Lady's mantle (Alchemilla vulgaris) extract PEG-15 soyamine Lemon (Citrus medica limonum) extract, peel

PPG-9 diethylmonium chloride extract

PPG-25 diethylmonium chloride Lemon bioflauonoids extract

PPG-40 diethylmonium chloride Lysimachia foenum-graecum extract

Propylene glycol stearate Magnolia spp. extract Quaternium-26, -27, -53, -62, -72 Mauritia flexosa extract

Rapeseedamidopropyl benzyldiomonium chloride Maximilliana regia extract

Rapeseedamidopropyl epoxypropyl dimonium Melaleuca uncinata, M. wilsonii extract chloride Melia australasica extract

Silica, colloidal Nettle (Urtica dioica) extract Sorbitan caprylate Oak (Quercus) bark extract

N-Soya-(3-amidopropyl)-N,N-dimethyl-N-ethyl Ocimum basilicum, O. santum extract ammonium ethyl sulfate Palmetto extract

Soyethyl morpholinium ethosulfate Passion flower (Passiflora laurifolia) fruit extract Plantain (Plantago major) extract Biol. polymer Polygonum multiflorum extract Distarch phosphate Pter carpus marsupianus extract Dog rose (Rosa canina) see extract Raspberry (Rubus) extract Hydrogen peroxide Sambucus nigra oil Kojic acid

Sanguisorbae root extract Mulberry (Moras nigra) extract Selinum spp. extract Sanguisorbae root extract Shorea robusota extract Tannic acid Botanical Walnut (Juglans regia) leaf extract, oil Acacia Wheat (Triticum vulgare) protein Acacia farnesiana extract White nettle (Lamium album) extract Agrimony (Agrimonia eupatoria) extract Witch hazel (Hamamelis virginiana) extract Alder (Alnus firma) extract Xanthozylum bungeanum extract Alfalfa (Medicago sativa) extract Zinc lactate Algae (Ascophyllum nodosum) extract

Ziziphus jujuba extract Algae (Lithotamnium calcarm) extract

Aloe barbadensis, A.b. extract

Binder Aloe capensis extract

Aluminum starch octenylsuccinate Alpine Veronica extract Boron nitride Althea officinalis extract

C20-40, C30-50, C40-60 alcohols Angelica archangelica extract

Calcium stearate Anise (Pimpinella anisum) extract

Cellulose gum Apple (Pyrus malus) extract

Dihydroabietyl behenate Apricot (Prunus armeniaca) extract Diisostearyl malate Arnica montana extract dioctyl sebacate Artemisia capillaris extract

Distarch phosphate Artichoke (Cynara scolymus) extract ethylcellulose Asafetida (Ferula assa foetida) extract

Gellan gum Asiasarum extract Hydrogenated jojoba oil Asparagus officinalis extract

Isocetyl alcohol, I. palmitate Astragalus sinicus extract

Isopropyl isostearate Avens (Geum rivale) extract

Isostearyl erucate, I. isostearate Avocado (persea gratissima) extract

Isostearyl neopentanoate Balm mint (Melissa officinalis) extract, oil Maltodextrin extract

Methylcellulose Vanana (Musa sapientum) extract

Microcrystalline cellulose Barley (Hordeum vulgare) extract

Octyl palmitate Basil (Ocimum basilicum) extract

Octyldodecyl myristate Bearberry (Arctostaphylos uvaOursi) extract bis-Octyldodecyl stearoyl dimer dilinoleate Bee pollen extract

Octyldodecyl stearoyl stearate Beet (Beta vulgaris) extract

Oleyl oleate Betaglucan

PEG-20, -75, -150, -240, -350 Bilberry (Vaccinium myrtillus) extract

Polydipentene Bioflavonoids Polyethylene; P. micronized Birch (Betula alba) bark extract, leaf extract

PTFE Birch (Betula platyphylla japonica( extract

PVP Bitter orange (Citrus aurantium amara) extract,

Sorbitol flower extract, peel extract

Synthetic wax Black cohosh (Cimicifuga racemosa) extract Tapioca dextrin Black currant (Ribes nigrum) extract

Tridecyl benenate, T. neopentanoate Black henna extract

Tridecyl stearoyl stearate Black poplar (Populus nigra) extract

Trisodium HEDTA Black walnut (Juglans nigra) extract Bladderwrack (Fucus vesiculosus) extract Dead Sea Mud, Salts

Borage (Borago officinalis) extract Dog rose (Rosa canina) hips extract

Buckthorn (Frangula alnus) extract Dyer's broom extract

Burdock (Arctium lappa) extract Eleuthero ginseng (Acanthopanax senticossus) Burdock (Arctium minus) root extract extract

Burnet extract Elm (Ulmus campestris) extract

Butcherbroom (Ruscus aculeatus) extract Eucalyptus (Eucalyptus globulus) extract

Cabbage rose (Rosa centifolia) extract Eucalyptus globulus oil

Calamus (Acorus calamus) extract Eucommia ulmoides extract Calendula officinalis extract Euphrasia officinalis extract

Caper (Capparis spinosa) extract Evening primrose (Oenothera biennis) extract, oil

Capsicum frutescens extract, C.f. oleoresin Everlasting (Helichrysum arenarium) extract

Caraway (Carum carvi) extract Fennel (Foeniculum vulgare) extract

Carrageenan (Chondrus crispus) Fenugreek extract Carrot (Daucus carota) extract Fermented rice (Oryza sativa) extract

Carrot (Daucus carota sativa) oil Fern (Dryopteris filix-Mas) extract

Cassia auriculata extract Fig (Ficus carica) extract

Celandine (Chelidonium majus) extract Fir needle extract

Chamomile (Anthemis nobilis) extract, oil Fumitory (Fumaria officinalis) extract Chaparral (Larrea mexicana) extract Gardenia florida extract

Cherry (Prunus speciosa) leaf extract Garlic (Allium sativum) extract

Cherry bark, C.b. extract Gelidium cartilagineum

Chestnut (Castanea sativa) extract Gentian (Gentiana lutea) extract

Chinese hibiscus (Hibiscus rosa-sinensis) extract Geranium maculatum extract Chlorella vulgaris extract Ginger root extract

Cimicifuga foetida rhizome extract Ginkgo biloba extract

Cinchona succiruba extract Ginseng (Panax ginseng) extract

Citroflavonoid, water soluble Glycyrrhetinic acid

Citrus bioflavonoid complex Glycyrrhizic acid Clary extract Glycyrrhizin ammoniated

Clove (Eugenia caryophyllus) extract Golden seal (Hydrastis canadensis) root extract)

Clover (Trifolium pratense) extract Goldthread (Coptis japonica) extract officinale rhizome extract, Co. Gotu kola extract water Grape (Vitis vinifera) distillate, extract Coffee (Coffea arabica) bean extract Grape (Vitis vinifera) leaf, seed extract oatmeal Grape skin extract (Tussilago farfara) leaf extract Grapefruit (Citrus grandis) peel extract (Symphytum officinale) leaf extract Green bean (Phaseolus lunatus) extract extract Ground Ivy (Glechoma hederacea) extract (Echinacea angustifolia) extract Guarana (Paullinia cupana) extract officinalis Harpagophytum procumbens extract olitorius extract Hay flower extract (Coriandrum sativum) extract Hazel (Corylus aveilana) nut extract (Zea mays) cob powder, silk extract Henna (Lawsonia inermis) extract poppy (Papaver rhoeas) extract Hesperidin, H, methyl chalcone (Centaurea cyanus) extract Hibiscus sabdariffa extract (Agropyron repens) grass Hibiscus syriacus extract monogina extract High beta-glucan barley flour maritimum extract Honeysuckle (Lonicera caprifolium) extract Cucumber (Cucumis sativus) extract Honeysuckle (Lonicera japonica) leaf extract

Cypress (Cupressus sempervirens) extract Hops (Humulus lupulus) extract

Dandelion (Taraxacum officinale) extract Horse chestnut (Aesculia hippocastanum) extract

Date (Phoenix dactylifera) extract Horseradish (Cochlearia armoracia) extract Horsetail extract Nasturtium extract

Houttuynia cordata extract Neroli extract

Hyacinth (Hyacinthus orientalis) extract nettle (Urtica dioica) extract

Hydrocotyl (Centella asiatica) extract Oak (Quercus) bark extract Hydrolyzed oat protein, soy flour Oak root extract

Hypericum perforatum extract Oat (Avena sativa) bran, bran extract, flour,

Hyssop (Hyssopus officinalis) extract protein

Indian cress (Tropaeolum majus) extract Oat flower

Isodonis Japonicus extract Olive (Olea europa) extract, leaf extract Ivy extract Onion (Allium cepa) extract

Japanese angelica (Angelica acutiloba) extract, Orange blossom extract water Orange (Citrus aurantium dulcis) flower extract,

Japanese hawthorn (Crataegus cuneata) extract peel extract

Jasmine (Jasminum officinale) extract Pansy (Viola tricolor) extract Job's tears (Coix lacryma-jobi) extract Papaya (Carica papaya) extract

Jojoba (Buxus chinensis) seed powder Parsley (Caram petroselinum) extract

Juniperus communis extract Passion flower (Passiflora laurifolia) frait extract

Kelp (Macrocystis pyrifera) extract Passionflower (Passiflora incarnata) extract

Kiwi (Actinidia chinensis) fruit extract, seed oil Pea (Pisum sativum) extract Kola (Cola acuminata) extract Peach (Prunus persica) extract, leaf extract

Krameria triandra extract Pelargonium capitatum extract

Lady's mantle (Alchemilla vulgaris) extract Pellitory (Parietaria officinalis) extract

Lady's Thistle (Silybum marianum) extract Pennyroyal (Mentha pulegium( extract

Laurel (Lauras nobilis) extract Peony (Paeonia albaflora) extract Lavender (Lavandula angustifolia) extract, water Peony (Paeonia obovata) root extract

Lemon (Citrus medica limonum) extract, juice Peppermint (Mentha piperita) extract, oil extract, peel extract Perilla ocymoides extract

Lemon bioflauonoids extract Periwinkle (Vinca minor) extract

Lemongrass (Cymbopogon schoenanthus) extract PEG-80 jojoba acid/alcohol Leopard flower (Belamcanda chinensis) root PEG- 120 jojoba acid/alcohol extract Pfaffia paniculata extract

Lettuce (Lactuca scariola sativa) extract Pheilodendron amurense extract

Licorice (Glycyrrhiza glabra) extract Pospholipids

Lilac (Syringa vulgaris) exract pimento (Pimenta officinalis) extract Linden (Tilia argentea) extract Pine (Pinus sylvestris) cone, needle extract

Linden (Tilia cordata) extract, water Pineapple (Ananas sativus) extract

Loquat (Eriobotrya japonica) leaf extract Plantain (Plantago major) extract

Maidenhair fern extract Pollen extract magnolia kobus extract Pongamol Mallow extract Poria Cocos extract

Mandragora officinaram extract Pueraria lobota extract

Mannan Queen of the meadow extract

Marigold Quillaja saponaria extract

Marine silts Quince (Pyras cydonia) seed extract Matricaria (Chamomilla recutita) extract Quinoa (Chenopodium quinoa) extract

Meadowsweet (Spiraea ulmaria) extract Raspberry (Rubus) extract

Melon (Cucumis melo) extract Rauwolfia (Serpentina) extract

MEA iodine Red clover

Mistletoe (Viscum album) extract Rehmannia chinensis extract Mugwort (Artemisia princeps) extract, water Restharrow (Ononis spinosa) extract

Mulberry (Moras alba) root extract Rhododendron chrysanthum extract

Mushroom extract Rhodophycea extract

Myrrh (Commiphora myrrha) extract Rhubarb (Rheum palmatum) extract Rice (Oryza sativa) bran extract Wild marjoram (Origanum vulgare) extract Rice fatty acid Willow (Salix alba) bark extract, extract

Rose'(Rosa multiflora) extract Willow (Salix alba) leaf extract Rosemary (Rosmarinus officinalis) extract Witch hazel (Hamamelis virginiana) extract Rubia tinctoram extract Yarrow (Achillea millefolium) extract

Safflower (Carthamus tinctorius) extract Yeast (Saccheromyces cerevisiae) extract (Faex) Sage (Salvia officinalis) extract, water Yucca vera extract Sambucus nigra berry extract, extract Zanthoxylum piperitum extract Sandalwood (Santalum album) extract Zedoary (Curcyma zedoraria) oil Sanguinaria canadensis extract Saponaria officinalis extract Buffer Sasa veitchii extract Ammonium carbonate, A. phoshate Saxifraga sarmentosa extract Calcium hydroxide, C. phosphate Scabiosa arvensis extract Citric acid Scutellaria baicatensis root extract Ethanolamine HC1 Silk extract Glycine

Silver fir (Abies pectinata) extract Phosphoric acid Sisal (Agave rigida) extract Potassium phosphate Slippery elm extract Potassium sodium tartrate Soapberry (Sapindus mukuross) extract Sodium acetate, S. citrate Sophora angustifolia extract Sodium lactate, S. phosphate Sophora flavescens root extract Succinic acid Sophora japonica extract Tromethamine Soybean (Glycine soja) extract Soy (Glycine soja) germ extract, protein, sterol Carrier Spearmint (Mentha viridis) extract, oil Acrylates copolymer, spherical powder Spinach (Spinacia oleracea) extract Arginine Spiraea ulmaria extract Caprylic/capric triglyceride Sunflower (Helianthus annuus) seed extract Caprylic/capric/lauric triglyceride Sweet almond (Prunus amygdalus dulcis) extract Caprylic/capric/oleic triglyceride Sweet chery (Pranus avium) extract Ceteareth-20 Sweet cicely (Anthriscus cerefolium) extract Coconut (Cocos nucifera) oil Sweet clover (Meliliotus officinalis) extract Cyclodextrin Sweet violet (Viola odorata) extract Dipropylene glycol Swertia chirata extract Glyceryl caprylate, G. caprylate/caprate

Tea (Camillia sinensis) extract Hydrated silica Thyme (Thymus vulgaris) extract Liposomes Tomato (Solanum lycopersicum) extract magnesium silicate Tormentil (Potentilla erecta) extract Methyl propanediol Tuberose (Polianthes tuberosa) extract PEG-8/SMDI copolymer Turmeric (Curcuma longa) extract Potassium chloride Valerian (Valeriana officinalis) extract PPG-12/SMDI Copolymer Walnut (Juglans regia) extract, leaf extract PPG-51/SMDI Copolymer Water Lily (Nymphaea alba) root extract Propylene carbonate, P. glycol Watercress (Nasturtium officinale) extract Serum albumin Wheat (Triticum vulgare) extract, protein Sodium carboxymethyl beta-glucan Wheat (Triticum vulgare) germ extract Sodium chloride Wheat bran lipids sodium magnesium silicate White ginger (Hedychium coronarium) extract Tapioca dextrin White nettle (Lamium album) extract

Wild agrimony (Potentilla anserina) extract Chelators Wild cherry (Pranus serotina) bark extract beta-Alanine diacetric acid Wild indigo (Baptista tinctoria) Calcium disodium EDTA Disodium EDTA, -copper Xanthozylum bungeanum extract

EDTA

HEDTA Cleansing

Malic acid Birch (Betula alba) leaf extract Monostearyl citrate Lemongrass (Cymbopogon schoenanthus) extract

Pentasodium pentetate Oat (Avena sativa) bran extract

Pentetic acid Passion glower (Passiflora laurifolia) frait extract

Phytic acid Witch hazel (Hamamelis virginiana) extract

Potassium aspartate Yarrow (Achillea millefolium) extract Sodium aspartate

Sodium dihydroxyethylglycinate Conditioner

Sodium hexametaphosphate Acetamide MEA

Tetrahydroxypropyl ethylenediamine 6-(N-Acetylamino)-4-oxyhexyltrimonium

Tetrasodium EDTA chloride Tripotassium EDTA Acrylamidopropyltrimonium chloride/acrylamide

Trisodium EDTA, HEDTA copolymer Adipic acid/dimethylaminohydroxypropyl

Cell stimulant diethylene triamine copolymer

Aesculus chinensis extract AMP-isostearoyl hydrolyzed wheat protein Artemisia apiacea extract Apricot (Prunus armeniaca) kernel oil

Astrocaryum mum, A. tucuma extract Behenalkonium chloride

Bactris gasipaes extract Behenamidopropyl dihydroxypropyl dimonium

Borojoa sorbilis extract chloride

Calendula amurrensis extract Benhenamidopropyl ethyldimonium ethosulfate Chyrsanthemum morifolium extract Benhenamidopropyl PG-dimonium chloride

Coccinea indica extract Behenamidopropyldimethylamine behenate

Comfrey (Symphytum officinale) leaf extract Behenamine oxide

Condurango extract Behenoyl PG-trimonium chloride

Dandelion (Taraxacum officinale) extract Behenyl betaine Echitea glauca extract Benzyltrimonium hydrolyzed collagen

Equisetum arvense extract Canolamidopropyl betain

Eucalyptus (Eucalyptus globulus) extract Capramide DEA

Euphotorium fortunei extract Caprylic/capric/lauric triglyceride

Euterpe precatoria extract Caprylyl pyrrolidone Ficus racemosa extract Cassia auriculata extract

Glycoproteins Cetamine oxide

Hierochloe odorata extract Cetearalkonium chloride

Horse chestnut (Aesculia hippocastanum) extract Chitosan PCA

Inga edulis extract Citric acid Kadsura heteliloca extract Cocamidopropyl dimethylamine, C.d. lactate,

Ligustram lucidum extract C.d. propionate

Lysimachia foenum-graecum extract Cocamidopropyl dimethylaminohydroxypropyl

Mauritia flexosa extract hydrolyzed collagen

Maximilliana regia extract Cocamidopropyldimonium Melaleuca bracteata, M. symphyocarp extract hydroxypropylhydrolyzed collagen

Nelumbium speciosum extract Cocamidopropyl ethyldimonium ethosulfate

Ocimum basilicum extract, O. santum extract Cocamidopropyl PG-dimonium chloride, C.P.c.

Paulownia imperialis extract phosphate

Pfaffia spp. extract Coco-morpholine oxide Pterocarpus marsupianus extract Coco/oleamidopropyl betaine

Rubus thunbergii extract Cocodimonium hydroxypropyl hydrolyzed hair

Selinum spp. extract keratin

Shorea robusota extract Cocodimonium hydroxypropyl hydrolyzed rice Hydroxycetyl hydroxyethyl dimonium chloride protein Hydroxyproline

Cocodimonium hydroxypropyl hydrolyzed silk Hydroxypropyl chitosan

Cocodimonium hydroxypropyl hydrolyzed soy Hydroxypropyl guar hydroxypropyltrimonium protein chloride

Coconut alcohol Hydroxypropyl-bis-

N-Cocoyl-(3-amidopropyl)-N,N-dimethyl-N-ethyl isostearyamidopropyldimonium chloride ammonium ethyl sulfate Hydroxypropyl bis-stearyldimonium chloride

Collagen phthalate Hydroxypropyltrimonium gelatin Dibehenyl/diarachidyl dimonium chloride Hydroxypropyltrimonium hydrolyzed keratin

Dibehenyldimonium chloride H.h. silk

Dicetyldimonium chloride Hydroxypropyltrimonium hydrolyzed wheat

Didecyldimonium chloride protein

Dihydroxyethyl cocamine oxide Isopropyl hydroxybutyramide dimethicone Dihydroxyethyl dihydroxypropyl stearmonium copolyol chloride Isopropyl lanolate

Dihydroxyethyl tallow glycinate Isostearamidopropyl betaine, I. dimethylamine

Dihydroxyethyl tailowamine oxide Isostearamidopropyl dimethylamine gluconate

Dilauryl acetyl dimonium chloride Isostearamidopropyl dimethylamine glycolate Dilinoleamidopropyl dimethylamine Isostearamidopropyl dimethylamine lactat

Dimethyl hydrogenated tailowamine Isostearamidopropyl ethyldimonium ethosulfate

Dimethyl lauramine, D.l. isostearate Isostearamidopropyl laurylacetodimonium

Dimethyl myristamine, soyamine, stearamine chloride

Dimethylamidopropylamine dimerate Isostearamidopropyl morpholine, I.m. lactate Disodium hydrogenated cottonseed glyceride Isostearamidopropyl morpholine oxide sulfosuccinate Isostearamidopropyl PG-dimonium chloride

Disodium laureth sulfosuccinate Isostearaminopropalkonium chloride

Disodium lauroamphodiacetate Isostearyl hydrolyzed animal protein

Distearyldimonium chloride Isostearylamidopropyl dihydroxypropyl Ethyl ester of hydrolyzed keratin dimonium chloride

N-Ethylether-bis- 1 ,4-(N-isostearylamidopropyl- Lactoglobolin N,N-dimethyl ammonium chlo Lauramidopropyl dimethylamine

Glutamic acid Lauramidopropyl PG-dimonium chloride, I.P.c.

Glyceryl collagenate phosphate Glycine Lauramine oxide

Guar hydroxypropyltrimonium chloride Lauroampho PG-glycinate phosphate

Henna (Lawsonia inermis) extract Lauroyl hydrolyzed collagen, L.h. elastin

Hydrogenated tailowamine oxide Lauroyl silk amino acids

Hydrogenated tallowtrimonium chloride Lauryl methyl gluceth-10 hydroxypropyl- Hydrolyzed conchiorin protein dimonium chloride

Hydrolyzed egg protein Lauryl phosphate, L. pyrrolidone

Hydrolyzed extensin Lauryldimonium hydroxypropyl hydrolyzed

Hydrolyzed fibronectin collagen, keratin, soy protein

Hydrolyzed fish protein Linoleamidopropyldimethylamine Hydrolyzed keratin Milk amino acids

Hydrolyzed lactalbumin Milk protein (Lactis proteinum)

Hydrolyzed milk protein Myristalkonium chloride

Hydrolyzed oats Myristamidopropyl betaine, M. dimethylamine

Hydrolyzed reticulin Myrtrimonium bromide Hydrolyzed soy protein Oat (Avena sativa) protein

Hydrolyzed sweet almond protein Oleamide

Hydrolyzed wheat protein/PVP copolymer Oleamidopropyl betaine, O. dimethylamine

Hydrolyzed wheat protein polysiloxane polymer Oleamidopropyl dimethylamine hydrolyzed Rice peptide collagen Ricinoleamidopropyl-dimonium ethosulfate

Oleamidopropylamine oxide Ricinoleamidopropyl betaine

Oleamine Ricinoleamidopropyl dimethylamine lactate Oleamine oxide Ricinoleamidopropyl ethyldimonium ethosulfate

Oleoyl sarcosine Ricinoleamidopropyltrimonium chloride

Oleyl betaine Ricinoleamidopropyltrimonium ethosulfate

Oleyl dimethylamidopropyl ethonium ethosulfate Silicone quateraium-3, -4

Palmitamidopropyl betaine Silk amino acids Palmitamidopropyl dimethylamine Sodium/TEA-lauroyl collagen amino acids

Palmitamine, P. oxide Sodium/TEA-lauroyl hydrolyzed keratin

Panthenyl hydroxypropyl steardimomum chloride Sodium/TEA-lauroyl keratin amino acids

PEG-2 milk solids Sodium citrate

PEG-2 oleammonium chloride Sodium cocoyl hydrolyzed soy protein PEG-3 lauramine oxide Sodium hydrogenated tallow dimethyl glycinate

PEG-5 stearyl ammonium lactate Sodium lauroyl collagen, keratin amino acids

PEG- 15 cocomonium chloride Sodium lauroyl wheat amino acids

PEG- 15 cocopolyamine Sodium stearoamphoacetate

PEG- 15 tallowmonium chloride Soluble keratin, wheat protein PEG-27 Soyamide DEA

PEG-40 Soyamidopropyl benzyldimonium chloride

PEG-85 lanolin Soyamidopropyl betaine, S. dimethylamine

PEG-7000 Soyamidopropyl ethyldimonium ethosulfate

Polydimethicone copolyol Soyethyl morpholinium ethosulfate Polymethacrylamidopropyltrimonium chloride Soyethyldimonium ethosulfate

Polyoxyethylene dihydroxypropyl linoleaminium Stearamide MEA chloride Stearamidoethyl diethylamine, ethanolamine

Polyquaternium-2, -5, -6, -11, -16 Stearamidopropyl benzyl dimonium chloride

Polyquaternium-17, -18, -24, -29, -44 Searamidopropyl cetearyl dimonium tosylate Potassium dimethicone copolyol panthenyl Stearamidopropyl dimethylamine stearate phosphate Stearamidopropyl ethyldimonium ethosulfate

Potassium lauroyl collagen amino acids Stearamidopropyl morpholine lactate

Potassium lauroyl hydrolyzed soy protein Stearamidopropyl PG-dimonium chloride

Potassium lauroyl wheat amino acids phosphate Potassium stearoyl hydrolyzed collagen Stearmine oxide

PPG-5 lanolin alcohol ether Steardimomum hydroxypropyl hydrolyzed

PPG-9 diethylmonium chloride collagen, keratin

PPG-20 lanolin alcohol ether Steardimonium panthenol

Proline Stearoyl amidoethyl diethylamine Propylene glycol stearate Steartrimonium bromide Stearyl dimethicone

PVP/dimethiconylacrylate/polycarbamyl/pol Tallowamidopropyl dimethylamine yglycol ester Tetramethyl trihydroxy hexadecane PVP/dimethylaminoethylmethacrylate copolymer TEA-cocoyl hydrolyzed collagen PVP/dimethylaminoethylmethacrylate/ Trachea hydrolysate polycarbamyl/polyglycol ester Tricetylmonium chloride PVP/hydrolyzed wheat protein copolymer Tridecyl salicylate Quaternium-22, -26, -33, -61 , -62, -70, -80 Triethonium hydrolyzed collagen ethosulfate Quaternium-76 hydrolyzed collagen Wheat germamidopropalkonium chloride Rapeseedamidopropyl benzyldimonium chloride Wheat germamidopropyl dimethylamine lactate Rapeseedamidopropyl epoxypropyl dimonium Wheat germamidopropyl ethyldimonium chloride ethosulfate Rapeseedamidopropyl ethyldimonium ethosulfate Wheat peptide Yeast powder, deproteinated Ammonium laureth sulfate Ammonium lauryl sulfate

Coupling agent Capramide DEA

Acetyl monoethanolamine Cocamidopropyl dimed ylamine lactate Butyloctanol Decyl glucoside

Myreth-3 Decyltetradeceth-25

Oleyl alcohol DEA lauryl sulfate

PPG-lO butanediol Diamyl sodium sulfosuccinate

PPG- 10 cetyl ether Dicyclohexyl sodium sulfosuccinate PPG-10 oleyl ether Diisobutyl sodium sulfosuccinate

PPG- 15 stearyl ether Disodium caproamphodiacetate

PPG-22 butyl ether Disodium caproamphodipropionate

PPG-23 oleyl ether Disodium capryloamphodiacetate

PPG-50 oleyl ether Disodium capryloamphodipropionate Trideceth-7 carboxy lie acid Disodium cetearyl sulfosuccinate Disodium cocamido MEA-sulfosuccinate

Denaturant Disodium cocamido MIPA-sulfosuccinate

Brucine sulfate Disodium cocoamphodipropionate

Denatonium benzoate, saccharide Disodium deceth-6 sulfosuccinate Nicotine sulfate Disodium isodecyl sulfosuccinate

Sucrose octaacetate Disodium lauramido MEA-sulfosuccinate Thymol Disodium lauramido PEG-2 sulfosuccinate Disodium laureth sulfosuccinate

Dental powder Disodium lauroamphodiacetate Dicalcium phosphate Disodium lauroamphodipropionate Silica Disodium lauryl sulfosuccinate

Sodium monofluorophosphate Disodium myristamido MEA-sulfosuccinate Stannous fluoride Disodium nonoxynol-10 sulfosuccinate Disodium oleamido PEG-2 sulfosuccinate Deodorant Disodium PEG-4 cocoamido MIPA-

Abietic acid sulfosuccinate

Azadirachta indica extract Disodium ricinoleamido MEA-sulfosuccinate

Chlorophyllin-copper complex Disodium tallowiminodipropionate

Eugenia jambolana extract Dodecylbenzene sulfonic acid Farnesol Dodoxynol-6, -9

Fermented vegetable Isopropylamine dodecylbenzenesulfonate

Mauritia flexosa extract Isostearamidopropyl betaine

Salvia miltiorrhiza extract Isosteareth-6 carboxylic acid

Sodium aluminum chlorohydroxy lactate Isostearoamphopropionate Spondias amara extract Isostearyl hydroxyethyl imidazoline

Triethyl citrate Lauramidopropylamine oxide

Zinc phenol sulfonate, Z. ricinoleate Laureth- 11

Lauroampho PG-glycinate phosphate

Depilatory Lauryl glucoside, L. phosphate Barium sulfide Magnesium laureth sulfate, M. lauryl sulfate

Beeswax, oxidized Magnesium PEG-3 cocamide sulfate

Calcium thioglycolate MEA-dodecylbenzenesulfonate

L-cysteine HCL MEA-laureth sulfate

Potassium thioglycolate MEA-lauryl sulfate Sodium thioglycolate MIPA-lauryl sulfate

Thioglycerin Myristamine oxide Myristic acid

Detergent Nonoxynol-10 Oleoamphohydroxypropyl sulfonate Benzalkonium chloride

Oleth-12, -15 Chlorophene

Oleyl betaine Didecyldimonium chloride

Palmitamidopropyl betaine Myristalkonium saccharinate PEG- 10 glyceryl stearate Shikonin

PEG- 15 glyceryl stearate Sodium capryloamphoacetate

PEG-25 glyceryl isostearate Tea tree (Melaleuca alternifolia) oil

Potassium cocoyl hydrolyzed collagen p-Tertarylphenol

Sodium caproamphoacetate Sodium cocoamphoacetate Dispersant

Sodium cocoamphopropionate Alkylated polyvinylpyrrolidone

Sodium cocomonoglyceride sulfate C20-40, C30-50, C40-60 alcohols

Sodium cocoyl hydrolyzed soy protein Castor (Ricinus communis) oil

Sodium cocoyl isethionate Ceteareth-20 Sodium C 12- 15 pareth-25 sulfate Cetyl PPG-2 isodeceth-7 carboxylate

Sodium C14-16 olefin sulfonate Cholesteryl/behenyl/octyldodecyl lauroyl

Sodium C14-17 alkyl secsulfonate glutamate

Sodium deceth sulfate Decaglycerol monodioleate

Sodium decyl diphenyl ether sulfonate Diisocetyl dodecanedioate Sodium dodecylbenzenesulfonate Diisostearyl adipate

Sodium dodecyldiphenyl ether sulfonate Dimethicone copolyol methyl ether

Sodium iodate Dioctyldodecyl dimer dilinoleate

Sodium laureth-2 sulfate Dioctyldodecyl dodecanedioate

Sodium laureth-3 sulfate Ethyl hydroxymethyl oleyl oxazoline Sodium laureth-7 sulfate Glyceryl caprylate, G. caprylate/caprate

Sodium laureth- 12 sulfate Glyceryl diisostearate

Sodium laureth- 13-carboxylate Hydrogenated castor oil, H. lecithin

Sodium laureth sulfate Hydrogenated tallow glycerides

Sodium lauriminodipropionate Isobutylene/MA copolymer Sodium lauroamphopropionate Isocetyl alcohol

Sodium lauroyl methyl alaninate Isopropyl C 12- 15-pareth-9-carboxy late

Sodium lauryl phosphate, S.l. sulfate Isostearyl neopentanoate

Sodium lauryl sulfoacetate Lanolin acid

Sodium methyl oleoyl taurate Laureth-4, -6, -16 Sodium methyl cocoyl taurate Melanin

Sodium methyllauroyltaurate Nonoxynol-2, -18, -20, -30, -40

Sodium methylnaphthalenesulfonate Octoxynol-5, -10

Sodium myreth sulfate Octoxynol 16, 30, 40, 70

Sodium myristyl sulfate Octyldodeceth-5 Sodium octyl sulfate, oleyl sulfate Octyldodecyl/dimetfiicone copolyol citrate

Sodium POE alkyl ether acetate Oleth-40

Sodium trideceth-7 carboxylate Oleyl alcohol

Sodium trideceth sulfate PEG-5 castor oil, glyceryl sesquioleate

Sodium tridecyl sulfate PEG-6 beeswax Steareth-11, -30 PEG-8/SMDI copolymer

TEA-dodecylbenzenesulfonate PEG-9 castor oil, oleate, stearate

TEA-laureth sulfate PEG- 10 dioleate, stearamine

TEA-lauryl sulfate PEG-12 beeswax

TEA-palm kernel sarcosinate PEG- 12 glyceryl dioleate, laurate TEA-PEG-3 cocamide sulfate PEG- 15 castor oil

Undecylenamidopropyl betaine PEG-20 almond glycerides

PEG-20 glyceryl isostearate

Disinfectant PEG-20 sorbitan triisostearate PEG-25 castoroil Behenamidopropyl dihydroxypropyl dimonium

PEG-30 dipolyhydroxystearate chloride

PEG-40 hydrogenated castor oil PCA isostearate Behenoxy dimethicone

PEG-60 shea butter glycerides Behenyl alcohol, B. behenate Poloxamer 101, 122, 181, 182, 184 Behenyl eracate, B. isostearate

Polyglyceryl-2 sesquiisostearate Benzyl laurate

Polyglyceryl-3 diisostearate, oleat Bladderwrack (Fucus vesiculosus) extract

Polyglyceryl-5 distearate Borage (Borago officinalis) seed oil

Polyglyceryl-6 mixed fatty acids Borageamidopropyl phosphatidyl PG-dimonium Poly glyceryl- 10 diisostearate, distearate chloride

Polyglyceryl-10 decaoleate Brain extract

Polyhydroxystearic acid Brazil nut (Bertholettia excelsa) oil

Polysorbate 40, 80 Butyl myristate, oleate, stearate

Potassium polyacrylate Butyloctanol PPG-3 PEG-6 oleyl ether Butyloctyl oleate

PPG-9 diethylmonium phosphate C12-13, C12-16, C14-15 alcohols

PPG-12/SMDI Copolymer C12-15 alcohols octanoate

PPG- 15 stearyl ether C12-15 alkyl benzoate

PPG-25, PPG-40 diethylmonium chloride dl-C12-15 alkyl fumarate PPG-51/SMDI Copolymer C 12-15 alkyl lactate

PVP/eicosene copolymer Camellia kissi oil

PVP/hexadecene copolymer Tea (Camellia sinensis) oil

Rapeseed oil, ethoxylated high eracic acid C 10-30 cholesterol/lanostearol esters

Ricinoleyl alcohol Canola oil Sodium ceteth-13-carboxylate Caprylic/capric triglyceride

Sodium lignosulfonate, S. polymethacrylate Caprylic/capric triglyceride PEG-4 esters

Sodium polynaphthalenesulfonate Caprylic/capric/lauric triglyceride

Sorbitan oleate Caprylic/capric/linoleic triglyceride

Steareth-10 Caprylic/capric/oleic triglycerides Tricontanyl PVP Caprylic/capric/stearic triglyceride

Triisostearin PEG-6 esters Caprylic/capric/succinic triglyceride

Trioctyldodecyl citrate Capsicum fratescens oleoresin Carrot (Daucus carota sativa) oil

Emollient Cashew (Anacardium occidentale) nut oil Acetylated glycol stearate Castor (Ricinus communis) oil

Acetylated hydrogenated lanolin Cetearyl behenate, C. candelillate

Acetylated hydrogenated lard glyceride Cetearyl isononanoate, C. octanoate

Acetylated hydrogenated vegetable glyceride Cetearyl palmitate, C. stearate

Acetylated lanolin, A.l. alcohol Ceteth-10 Acetylated lard glyceride Cetostearyl stearate

Acetylated monoglycerides Cetyl C12-15 pareth-9 carboxylate

Acetylated palm kernel glycerides Cetyl acetate, C. alcohol

Aleurites moluccana ethyl ester Cetyl esters, C. lactate

Allantoin Cetyl myristate, C. octanoate Aluminum/magnesium hydroxide stearate Cetyl oleate, C. palmitate

AMP-isostearoyl hydrolyzed soy protein Cetyl PPG-2 isodeceth-7 carboxylate

Apricot (Prunus armeniaca) karnel oil Cetyl ricinoleate, C. stearate

Arachidyl behenate Cetyl stearyl octanoate

Argania spinosa oil Chia (Salvia hispanica) oil Avocado (Persea gratissima) oil, unsaponifiables Cholesteric esters

Avocado oil ethyl ester Cholesterol

Babassu (Orbignya oleifera) oil Cholesteryl/behenyl/octyldodecyl lauroyl

Batyl isostearate, B. stearate glutamate Cholesteryl hydroxystearate Dimethiconol stearate

Cholesteryl stearate Dimethyl lauramine oleate

Choϊeth-24 Dioctyl adipate

C18-70 Isoparaffin Dioctyl dimer dilinoleate C10-18, C12-18 triglycerides Dioctylcyclohexane

C 12-15 linear alcohols 2-ethylhexanoate Dioctyldodecyl dimer dilinoleate

Cocamidopropyl PG-dimonium chloride Dioctyldodecyl dodecanedioate

Cocoa (Theobroma cacao) butter Dioctyl malate, D. sebacate, succinate

Coco-caprylate/caprate Dipentaerythritol fatty acid ester Coco-rapeseedate Dipentaerythrityl hexacaprylate/hexacaprate

Coconut (Cocos nucifera) oil Dipentaerythrityl hexahydroxystearate/isostearate

Cocoyl hydrolyzed soy protein Distearyldimethylamine dilinoleate

Collagen hthalate Ditridecyl adipate

Colloidal oatmeal Dog rose (Rosa canina) hips oil Comfrey (Symphytum officinale) leaf extract Egg (Ovum) yolk extract

Corn (Zea mays) oil Emu (Dromiceius) oil

Corn poppy (Papaver rhoeas) extract Eracyl eracate

Cottonseed (Gossyplum) oil Ethyl avocadate

Cuttlefish extract Ethylhexyl isopalmitate Cyclomethicone 2-Ethylhexyl isostearate

Deceth-4 phosphate Ethyl linoleanate, E. minkate

Decyl oleate Ethyl morrhuate, E. myristate

Decyltetradecanol Ethyl oleate, E. olivate

Dialkydimethylpolysiloxane Evening primrose (Oenothera biennis) extract, oil Dibutyl sebacate Glycereth-4,5-lactate

Dicapryl adipate Glycereth-5 lactate

Dicaprylyl ether, D. maleate Glycereth-7 benzoate

Diethylene glycol diisononanoate Glycereth-7 diisononanoate

Diethylene glycol dioctanoate Glycereth-7 triacetate bis-Diglyceryl/caprylate/caprate/isostearate/ Glycereth-7 trioctanoate hydroxystearate/adipate Glycereth-12, -26 bis-Diglyceryl/caprylate/caprate/isosteareth/ Glycerol tricaprylate/caprate stearate/hydroxystearate/adipate Clyceryl adipate, G. dioleate

Dihydroabietyl behenate Glyceryl isostearate, G. lanolate Dihydroxyethyl tailowamine oleate Glyceryl linoleate, G. monopyroglutamate

Diisobutyl adipate Glyceryl myristate, G. oleat

Diisocetyl adipate, dodecanedioate Glyceryl ricinoleate

Diisodecyl adipate Glyceryl triacetyl hydroxystearate

Diisopropyl adipate, dimer dilinoleate Glyceryl triacetyl ricinoleate Diisopropyl sebacate Glycosaminoglycans

Diisostearoyl trimethylolpropane siloxy silicate Glycosophingolipids

Diisostearyl adipate Gold of Pleasure oil

Diisostearyl dimer dilinoleate Grape (Vitis vinifera) seed oil

Diisostearyl fumarate, D. malate Hazel (Corylus avellana) nut oil Dilinoleic acid Helianthus annum ethyl ester

Dimethicone Hexadecyl isopalmitate

Dimethicone copolyol Hexamethyldisiloxane

Dimethicone copolyol acetate, D.c. almondate hexyl laurate hexyldecanol Dimethicone copolyol isostearate, D.c. lactate Hexyldecyl stearate Dimethicone copolyol methyl ether honey extract Dimethicone copolyol phthalate Hybrid safflower (Carthamus tinctorius) oil Dimethicone propylethylenediamine behenate Hybrid sunflow (Helianthus annus) oil Hydrogenated C6-14 olefin polymers Isosorbide laurate

Hydrogenated castor oil Isostearic acid

Hydrogenated castor oil laurate Isostearyl alcohol hydrogenated coconut oil Isostearyl behenate, I. benzoate Hydrogenated cottonseed oil Isostearyl diglyceryl succinate

Hydrogenated C12-18 triglycerides Isostearyl eracate, I. eracyl erucate

Hydrogenated lanolin Isostearyl isostearate, I. lactate

Hydrogenated lanolin, distilled Isostearyl malate, I. myristate

Hydrogenated lecithin Isostearyl neopentanoate, palmitate Hydrogenated milk lipids Isostearyl stearoyl stearate

Hydrogenated mink oil Isostearylamidopropyl dihydroxypropyl

Hydrogenated palm kernel glycerides dimonium chloride

Hydrogenated palm oil Isotridecyl isononanoate

Hydrogenated polyisobutene Isotridecyl myristate Hydrogenated soybean oil Jojoba (Buxus chinensis) oil

Hydrogenated starch hydrolysate Jojoba butter, J. esters

Hydrogenated tallow glyceride Jojoba oil, synthetic

Hydrogenated tallow glyceride lactate Kukui (Aleurites molaccana) nut oil

Hydrogenated turtle oil Lactamide DGA Hydrogenated vegetable glycerides Laneth-10 acetate

Hydrogenated vegetable oil Lanolin, L. acid

Hydrolyzed collagen Lanolin alcohol, L. oil

Hydrolyzed conchiorin protein Lanolin, ultra anhydrous

Hydrolyzed keratin Lanolin wax Hydrolyzed mushroom (Tricholoma matsutake) Lanostearol extract Lard glyceride

Hydrolyzed oat protein Laureth-2, -3

Hydroxylated lanolin Laureth-2 acetate, L. benzoate

Hydrolylated milk glycerides Laureth-2-octanoate Hydroxystearic acid Lauric/palmitic/oleic triglyceride butter Lauryl behenate, L. lactate

Isobutyl palmitate, I. stearate Lauryl phosphae

Isocetyl behenate, I. octanoate Lauryldimethylamine isostearate

Isocetyl palmitate, I. salicylate Lesquereila fendleri oil Isocetyl stearate Linoleic acid

Isodeceth-2 cocoate Macadamia ternifolia nut oil

Isodecyl citrate, I. cocoate Maleated soybean oil

Isodecyl isononanoate, I. laurate Mango (Magnifera indica) oil, seed oil

Isodecyl neopentanoate Mango kernel oil Isodecyl octanoate, I. oleate Meadowfoam (Limnanthes alba) seed oil

Isodecyl stearate Menhaden (Brevoortia tyrannus) oil

Isododecane Methyl acetyl ricinoleate

Isoeicosane Methyl gluceth-20

Isohexadecane Methyl gluceth-20 benzoate, M.g. distearate isononyl isononanoate Methyl hydroxystearate, M. ricinoleate

Isopentyldiol Microcrystalline wax

Isopropyl avocadate Mineral oil (Paraffinum liquidum)

Isopropyl C12-15-pareth-9-carboxylate Mink oil

Isoproyl isostearate Musk rose (Rosa moschata) oil Isopropyl lanolate, I. linoleate Myreth-3

Isopropyl myristate, I. palmitate Myreth-3 caprate, M. laurate

Isopropyl PPG-2-isodeceth-7 carboxylate Myreth-3 myristate, M. octanoate

Isopropyl sterate Myristyl alcohol, M. lactate Myristyl myristate, M. octanoate PEG-9 stearyl stearate

Myristyl propionate, M. stearate PEG- 10 stearyl stearate

Neatsfόot oil PEG-12

Neem (Melia azadirachta) seed oil PEG-12 dioleate, P. palm kernel glycerides Neopentyl glycol dicaprate PEG- 15 cocamine oleate/phosphate

Neopentyl glycol dicaprate/dicaprylate PEG- 18

Neopentyl glycol diisooctanoate PEG-20

Neopentyl glycol dioctanoate PEG-20 hydrogenated castor oil isostearate

Oat (A vena sativa) bran extract, extract, flour PEG-20 hydrogenated castor oil triisostearate Octacosanyl stearate PEG-20 hydrogenated lanolin

Octyl cocoate PEG-24 hydrogenated lanolin

Octyl hydroxystearate, O. isononanoate PEG-25 PABA, P. propylene glycol stearate

Octyl neopentanoate, O. octanoate PEG-40 glyceryl laurate

Octyl oleate, O. palmitate PEG-40 hydrogenated castor oil isostearate Octyl pelargonate, O. stearate PEG-40 hydrogenated castor oil laurate

Octyldecanol PEG-40 hydrogenated castor oil triisostearate

Octyldodecanol PEG-40 jojoba oil

Octyldodecyl behenate, O. benzoate PEG-50 hydrogenated castor oil laurate

Octyldodecyl erucate, O. myristate PEG-50 hydrogenated castor oil triisostearate Octyldodecyl oleate, O. ricinoleate PEG-60 shea butter glycerides

Octyldodecyl stearate PEG-70 mango glycerides bis-Octyldodecyl stearoyl dimer dilinoleate PEG-75

Octyldodecyl stearoyl stearate PEG-75 lanolin, P. shea butter glycerides

Oleamine oxide PEG-75 shorea butter glycerides Oleic/palmitoleic/linoleic glycerides PEG- 150

Oleic alcohol PEG/PPG- 17/6 copolymer

Oleostearine Pentaerythrityl dioleate

Oleyl alcohol, O. erucate, O. oleate Pentaerythrityl

Olive (Olea europa) oil isostearate/caprate/caprylate/adipate Orange (Citrus aurantium dulcis) peel wax Pentaerythrityl stearate

Orange roughy (Hoplostethus atlanticus) oil Pentaerythrityl stearate/caprate/caprylate/adipate

Palm (Elaeis guineensis) oil Pentaerythrityl tetracaprylate/tetracaprate

Palm kernel glycerides Pentaerythrityl tetraisononanoate, P.

Palmitic acid tetraisostearate Panthenyl triacetate Pentaerythrityl tetralaurate, P. tetraoctanoate

Partially hydrogenated canola oil Pentaerythrityl tetraoleate, P. tetrapelargonate

Partially hydrogenated soybean oil Pentaerythrityl tetrastearate

Peach (Prunus persica) extract Perfluorodecalin

Peanut (Arachis hypogaea) oil Perfluoropolymethylisopropyl ether PEG-2 diisononanoate, P. dioctanoate Petrolatum

PEG-2 milk solids Phenethyl dimethicone

PEG-4 Phenyl dimethicone, P. methicone, P.

PEG-4 diheptanoate, P. dilaurate trimethicone

PEG-5 C8-12 alcohols citrate Phytantriol PEG-5 C14-18 alcohols citrate Pistachio (Pistacia vera) nut oil

PEG-5 hydrogenated castor oil Placental enzymes

PEG-5 hydrogenated castor oil triisostearate Pollen extract

PEG-6 Poloxamer 105 benzoate

PEG-6 capric/caprylic glycerides Poloxamer 182 dibenzoate PEG-7 glyceryl cocoate Polybutene

PEG-8 Polydecene

PEG-8 dilaurate, P. dioleate Polydimethicone copolyol

PEG-8/SMDI copolymer Polyethylene glycol Polyglyceryl-2 diisostearate, P. tetraisostearate PPG-30

Polyglyceryl-2 triisostearate PPG-30 cetyl ether

Polyglyceryl-3 diisostearate, P. oleate PPG-40 butyl ether

Polyglyceryl-3 stearate PPG-50 cetyl ether, P. oleyl ether Polyglyceryl-6 dioleate PPG-51/SMDI Copolymer

Polyglyceryl-10 decaoleate, P. decastearate PPG-53 butyl ether

Polyglyceryl-10 tetraoleate Propylene glycol ceteth-3 acetate

Polyisobutene Propylene glycol dicaprylate

Polyisobutene/isohexapentacontahectane Propylene glycol dicaprylate/dicaprate Poly isobutene/isooctabexacontane Propylene glycol diisostearate, P.g. dioctanoate

Polyisobutene/isopentacontaoctane Propylene glycol dipelargonate

Polyisoprene Propylene glycol isoceteth-3-acetate

Polyoxyethylene polyoxypropylene glycol Propylene glycol isostearate, P.g. laurate

Polyquaternium-2 Propylene glycol myristate Polysiloxane polyalkylene copolymer Propylene glycol myristyl ether acetate

Polysorbate 40 Propylene glycol stearate, SE

Potassium dimethicone copolyol phosphate Pumpkin (Cucurbita pepo) seed oil

PPG-2-buteth-3 Quinoa (Chenopodium quinoa) oil

PPG-2 lanolin alcohol ether Rapeseed (Brassica campestris) oil PPG-2 myristyl ether propionate Rice (Oryza sativa bran oil, bran wax

PPG-3 hydrogenated castor oil Rice fatty acid

PPG-3 myristyl ether Safflower (Carthamus tinctorius) oil

PPG-5-buteth-7 Salmon (Salmo) egg extract

PPG-5-laureth-5 Sesame (Sesamum indicum) oil PPG-5 butyl ether Shark liver oil

PPG-5 lanolin wax Shea butter (Butyrospermum parkii)

PPG-5 pentaerythrityl ether Shea butter (Butyrospermum parkii) extract

PPG-7-buteth-10 Shea butter, ethoxylate

Shorea stenoptera butter PPG-8/SMDI copolymer Silybum marianum ethyl ester

PPG-9 Sitostearyl acetate

PPG-9-buteth-12 Skin lipids

PPG-9 butyl ether Slippery elm extract

PPG-10 butanediol, P. cetyl ether Sodium C8-16 isoalkylsuccinyl lactoglobulin PPG-10 methyl glucose ether sulfonate

PPG-10 oleyl ether Sodium carboxymethyl beta-glucan

PPG- 11 stearyl ether Sodium ceteth-13-carboxylate

PPG-12-butheth-16 Sodium dimethicone copolyol acetyl

PPG-12-PEG-50 lanolin methyltaurate PPG-12-PEG-65 lanolin oil Soium glyceryl oleate phosphate

PPG-12/SMDI Copolymer Sodium hyaluronate, S. poly methacry late

PPG-14 butyl ether Sorbeth-20

PPG-15 butyl ether, P. stearyl ether Sorbitan isosteraate, S. palmitate

PPG- 15 stearyl ether benzoate Sorbitan sesquioleate, S. sesquistearate PPG-16 butyl ether Sorbitan trioleate

PPG- 18 butyl ether Soybean (Glycine soja) oil

PPG-20 Spermaceti

PPG-20-buteth-30 Sphingolipids

PPG-20 cetyl ether Squalene PPG-24-glycereth-24 Stearamidopropyl cetearyl dimomum tosylate

PPG-26 Steareth-4 stearate

PPG-27 glyceryl ether Stearic acid, S. hydrazide

PPG-28-buteth-35 Stearoxy dimethicone Stearoxymethicone/dimethicone copolymer 2-Aminobutanol

Stearyl behenate, S. benzoate Ammonium acrylates/acrylonitrogens copolymer

Stearyf dimethicone, S. erucate Arachidyl alcohol

Stearyl heptanoate, S. propionate Beeswax Stearyl stearate Behenamidopropyl dihydroxypropyl dimomum

Stearyl stearoyl stearate chloride

Sucrose cocoate Beheneth-5, -10, -20, -30

Sunflower (Helianthus annuus) seed oil Behenic acid

Sweet almond (Prunus amygdalus dulcis) oil Behenyl betain Sweet cherry (Prunus avium) pit oil Borageamidopropyl phosphatidyl PG-dimonium

Synthetic jojoba oil chloride

Synthetic wax Butyloctanol

Tallow C 12-20 acid PEG-8 ester

Tetradecycleicosyl stearate C 18-36 acid Tocopheryl acetate Calcium dodecylbenzene sulfonate

Tricaprin Calcium protein complex

Tricaprylin Calcium stearate

Tricaprylyl citrate Calcium stearoyl lactylate

Tricholoma matsutake extract Capramide DEA Tridecyl behenate, T. cocoate Caprylic/capric acid

Tridecyl erucate, T. neopentanoate Caprylic/capric glycerides

Tridecyl octanoate, T. stearate Castor oil, ethoxylate

Tridecyl stearoyl stearate Cetalkonium chloride

Tridecyl trimellitate Ceteareth-2 -4 -5 -6 Trihexyldecyl citrate Ceteareth-2 phosphate

Triisocetyl citrate Ceteareth-5 phosphate

Triisostearin Ceteareth-8 -10 -11 -12

Triisostearyl citrate Ceteareth-10 phosphate

Triisostearyl trilinoleate Ceteareth-15 -17 -20 -25 Trilaurin Ceteareth-27 -29 -30 -34

Trilinolein Cetearyl alcohol

Trimethylolpropane tricaprylate/tricaprate Cetearyl glucoside

Trimethylolpropane tricocoate Ceteth-2 -4 -6 -10 -12 -13

Trimethylolpropane trilaurate Ceteth-16 -20 -25 -30 -33 Trimyristin Cetethyldimonium bromide

Trioctanoin Cetrimonium chloride

Trioctyldodecyl citrate Cetyl dimethicone copolyol

Triolein Cetyl phosphate

Tripalmitin Cholesterol Tripropylene glycol citrate Choleth-10 -15 -24

Tristearin Cocamide DEA, C. MEA

Triundecanoin Cocamidopropyl dimethylamine

Vegetable oil Cocamidopropyl PG-dimonium chloride

Walnut (Juglans regia) oil phosphate Wheat (Triticum vulgare) germ oil Cocamine

Coceth-7 carboxylic acid

Emulsifier Coconut acid

Acetylated hydrogenated lard glyceride Copper protein complex Acetylate hydrogenated vegetable glyceride Cottonseed glyceride Acetylated monoglycerides C12-13 pareth-3 -4 -9 -23

Acrylates/C10-C30 alkyl acrylate crosspolymer C16-18 pareth-3 -5.5 -13 -19 Acrylates/vinyl isodecanoate crosspolymer Cyclodextrin Acrylic acid/acrylonitrogens copolymer Decaglycerol monodioleate DEA-ceteareth-2-phosphate Glyceryl ricinoleate SE

DEA-cetyl phosphate Glyceryl stearate, G. stearate citrate

DEA-cyclocarboxypropyloleate Glyceryl stearate lactate

DEA-oleth-3-phosphate Glyceryl stearate SE DEA-oleth-5-phosphate Glyceryl undecylenate

DEA oleth-10 phosphate Glycol distearate, G. oleate

DEA-oleth-20-phosphate Glycol palmitate, G. stearate

Diceteareth-10 phosphoric acid Glycol stearate SE

Diethanolamine Glycolamide stearate Diethylaminoethyl stearate Glycosphingolipids

Diglyceryl stearate malate Hydrogenated coco-glycerides

Dihydrocholeth-15 -20 -30 Hydrogenated cottonseed glyceride

Dihydrogenated tallow phthalic acid amide Hydrogenated lanolin

Dilauryl acetyl dimonium chloride Hydrogenated lecithin Dilinoleamidopropyl dimethylamine dimethicone Hydrogenated palm oil copolyol phosphate Hydrogenated soy glyceride

Dilinoleic acid Hydrogenated tallow glycerides

Dimethicone copolyol almondate Hydrogenated tallow glycerides citrate

Dimethicone copolyol isostearate Hydroxycetyl phosphate Dimethicone copolyol laurate Hydroxylated lanolin

Dimethicone copolyol methyl ether Hydroxylated lecithin

Cimethicone copolyol olivate Hydroxyoctacosanyl hydroxystearate

Dimethicone copolyol phthalate Hydroxypropyl-bis-

Dipalmitoylethyl hydroxyethylmonium isostearyamidopropyldimonium chloride methosulfate Isoceteareth-8 stearate

Dipropylene glycol Isoceteth-10 stearate

Disodium hydrogenated cottonseed glyceride Isoceteth-20 sulfosuccinate Isocetyl alcohol

Disodium ricinoleamido MEA-sulfosuccinate Isolaureth-6 Disodium stearyl sulfosuccinate Isostearamidopropyl dimethylamine gluconate

Disodium sulfosuccinamide Isostearamidopropyl dimethylamine glycolate

Distearyl phthalic acid amide Isostearamidopropyl laurylacetodimonium

N-Dodecyl-N,N-dimethyl-N-(dodecyl acetate) chloride ammonium chloride Isosteareth-2 -3 -10 -12 -20 -22 -50 Dodecylphenol-ethylene oxide condensate Isostearth-2 -octanoate

Egg (Ovum) yolk extract Isostearth-10 stearate

Emulsifying wax NF Isostearic acid

Ethoxylated fatty alcohol isostearyl diglyceryl succinate

N-Ethylether-bis- 1 ,4-(N-isostearylamidopropyl- Isostearylamidopropyl dihydroxypropyl N,N-dimethyl ammonium chlo dimonium chloride

Ethyl hexanediol Karaya (Stericulia urens) gum

Euglena gracilis polysaccharide Laneth-5 -10 -15 -16 -20 -40

Glycereth-26 phosphate Laneth-10 acetate

Glyceryl caprylate, G. caprylate/caprate Lanolin Glyceryl citrate/lactate/linoleate/oleate Lanolin alcohol

Glyceryl cocoate, G. dilaurate Lanolin, ultra anhydrous

Glyceryl dilaurate, G. dioleate Lanolin wax

Glyceryl distearate, G. hydroxystearate Lauramide DEA, L. MEA

Glyceryl isostearate, G. lanolate Lauramidopropyl dimethylamine Glyceryl laurate, G. linoleate Lauramidopropyl PG-dimonium chloride

Glyceryl mono-di-tri-caprylate Laureth- 1 -2 -3 -4 -5

Glyceryl myristate, G. oleate Laureth-2-octanoate

Glyceryl palmitate, G. ricinoleate Laureth-3 phosphate Laureth-4 carboxylic acid PEG-3 cocamide

Laureth-5 carboxylic acid PEG-3 C12-C 18 alcohols

Lauretή-6 -7 -9 -11 -12 PEG-3 glyceryl isostearate

Laureth- 11 carboxylic acid PEG-3 glyceryl triisostearate Laureth- 16 -20 -23 -25 -30 PEG-3 glyceryl tristearate

Lauryl PCA PEG-3 lanolate, P. sorbitan oleate

Laurylmethicone copolyol PEG-3 stearate

Lecithin PEG-4 dioleate, P. diisostearate

Linoleamidopropyl PG-dimonium chloride PEG-4 dilaurate, P. distearate phosphate PEG-4 glyceryl distearate

Lithium stearate PEG-4 laurate, P. oleate

Magnesium sulfate hepta-hydrate PEG-4 stearate

Maleated soybean oil PEG-4 stearyl stearate

Methoxy PEG-17/dodecyl glycol copolymer PEG-4 tallate Methyl gluceth-20 distearate PEG-5 castor oil, P. cocamine methyl glucose dioleate, M.g. sesquiisostearate PEG-5 C12-C18 alcohols

Methyl glucose sesquistearate PEG-5 glyceryl isostearate

MEA-laureth sulfate PEG-5 glyceryl sesquioleate

Myreth-3 -4 -7 PEG-5 glyceryl stearate Myreth-3 myristate PEG-5 glyceryl triisostearate

Myristamidopropyl dimethylamine PEG-5 lanolate, P. oleamine

Nonoxynol-1 -2 -4 -5 -6 -7 PEG-5 soy sterol, P. soyamine

Nonoxynol-8 -9 -10 -11 -12 -13 PEG-5 stearamine, P. stearate

Nonoxynol-14 -15 -18 -20 -30 -40 -50 PEG-5 tallow amine Nonyl nonoxynol-5 -10 PEG-6 capric/caprylic glycerides

Oat (Avena sativa) flour PEG-6 cocamide

Octoxynol-1 -3 -5 -8 -10 PEG-6 C12-14 ether

Octoxynol 16, 30, 40 PEG-6 dilaurate, P. dioleate

2-Octyl dodecyl alcohol PEG-6 distearate, P. isostearate Octyldodecanol PEG-6 lauramide, P. laurate

Octyldodeceth-20 -25 PEG-6 oleate, P. palmitate

Oleamide DEA PEG-6 sorbitan beeswax

Oleamidopropyl dimethylamine PEG-6 sorbitan laurate

Oleamine oxide PEG-6 sorbitan oleate Oleic acid PEG-6 sorbitan stearate

Oleth-2 -3 -4 -5 -6 -7 -8 -9 PEG-6 stearate

Oleth-10 -12 -15 -20 -23 PEG-6-32

Oleth-25 -30 -40 -50 PEG-6-32 stearate

Oleth 13 PEG-7 glyceryl cocoate Oleth-2 phosphate PEG-7 hydrogenated castor oil

Oleth-3 phosphate PEG-7 oleate

Oleth-5 phosphate PEG-7.5 tailowamine

Oleth-10 phosphate PEG-8

Oleth-20 phosphate PEG-8 beeswax, P. castor oil Palm acid PEG-8 C12-14 ether

Palmitamidopropyl dimethylamine PEG-8 dilaurate, P. dioleate

Palmitic acid PEG-8 distearate

PEG-2 cocamine, P. distearate PEG-8 glyceryl laurate

PEG-2 hydrogenated tallow amine PEG-8 laurate, P. oleate PEG-2 laurate, P. laurate SE PEG-8, P. tallate

PEG-2 oleamine, P. oleate PEG-9 castor oil

PEG-2 soyamine, P. stearamine PEG-9 diisostearate

PEG-2 stearate, P. stearate SE PEG-9 dioleate, P. distearate PEG-9 laurate, P. oleate PEG-23 oleate, P. stearate

PEG-9 stearate PEG-24 hydrogenated lanolin

PEG- 10 castor oil, P. cocamine PEG-25 castor oil

PEG- 10 coconut oil esters PEG-25 phytosterol PEG-10 C12-18 alcohols PEG-25 propylene glycol stearate

PEG- 10 dioleate PEG-25 soy stearol, P. stearate

PEG-10 glyceryl isostearate PEG-29 castor oil

PEG-10 hydrogenated castor oil PEG-30 castor oil

PEG-10 hydrogenated castor oil triisostearate PEG-30 dipolyhydroxystearate PEG-10 lanolate PEG-30 glyceryl cocoate

PEG-10 polyglyceryl-2 laurate PEG-30 glyceryl isostearate

PEG-10 sorbitan laurate PEG-30 glyceryl laurate

PEG-10 soy sterol, P. stearamine PEG-30 glyceryl oleate

PEG-10 stearate PEG-30 glyceryl stearate PEG- 11 babassu glycerides PEG-30 hydrogenated castor oil

PEG- 11 castor oil PEG-30 lanolin

PEG-12 dilaurate, P. dioleate PEG-30 sorbitan tetraoleate

PEG-12 distearate PEG-32 dilaurate, P. dioleate

PEG-12 glyceryl dioleate PEG-32 distearate, P. laurate PEG-12 laurate, P. oleate PEG-32 oleate, P. stearate

PEG-12 stearate, P. tallate PEG-33 castor oil

PEG- 14 avocado glycerides PEG-35 castor oil, P. stearate

PEG- 15 castor oil PEG-40 castor oil

PEG- 15 cocamine PEG-40 glyceryl isostearate PEG- 15 glyceryl isostearate PEG-40 glyceryl laurate

PEG- 15 glyceryl laurate PEG-40 glyceryl triisostearate

PEG- 15 glyceryl ricinoleate PEG-40 hydrogenated castor oil

PEG-15 oleamine, P. oleate PEG-40 hydrogenated castor oil PCA isostearate

PEG- 15, P. stearamine PEG-40 sorbitan diisostearate PEG-15 tallow amine PEG-40 sorbitan lanolate

PEG-15 tallow polyamine PEG-40 sorbitan tetraoleate

PEG- 16 PEG-40 stearate

PEG- 16 hydrogenated castor oil PEG-40/dodecyl glycol copolymer

PEG- 16 soy sterol PEG-42 babassu glycerides PEG- 18 stearate PEG-44 sorbitan laurate

PEG-20 almond glycerides PEG-45 palm kernel glycerides

PEG-20 castor oil, P. dilaurate PEG-45 safflower glycerides

PEG-20 dioleate, P. distearate PEG-50 lanolin, P. stearamine

PEG-20 glyceryl laurate PEG-50 stearate PEG-20 glyceryl oleate PEG-60 almond glycerides

PEG-20 glyceryl stearate PEG-60 castor oil

PEG-20 glyceryl triisostearate PEG-60 corn glycerides

PEG-20 glyceryl tristearate PEG-60 glyceryl triisostearate

PEG-20 hydrogenated castor oil PEG-60 hydrogenated castor oil PEG-20 hydrogenated lanolin PEG-60 hydrogenated castor oil isostearate

PEG-20 lanolin, P. laurate PEG-60 hydrogenated castor oil triisostearate

PEG-20 oleate PEG-60 shea butteer glycerides

PEG-20 methyl glucose sesquistearate PEG-60 sorbitan tetraoleate

PEG-20 sorbitan beeswax PEG-70 mango glycerides PEG-20 sorbitan isostearate PEG-75

PEG-20 sorbitan triisostearate PEG-75 castor oil, P. dilaurate

PEG-20 sorbitan trioleate PEG-75 dioleate, P. distearate

PEG-20 stearate, P. tallow amine PEG-75 lanolin, P. laurate PEG-75 oleate Polyglyceryl-10 trioleate

PEG-75 shea butter glycerides Polyoxyethylene polyoxypropylene glycol

PEG-75 shorea butter glycerides Polyquaternium-5, -31

PEG-75 stearate Polysorbate 20, 21, 40, 60, 61 PEG-80 sorbitan laurate Polysorbate 65, 80, 81, 85

PEG-90 stearate Potassium alginate, P. cetyl phosphate

PEG- 100 castor oil Potassium laurate, P. myristate

PEG- 100 hydrogenated castor oil Potassium tailowate

PEG- 100 lanolin, P. stearate PPG- 1 -PEG-9 lauryl glycol ether PEG-120 distearate PPG-2-ceteareth-9

PEG-150 dilaurate, P. dioleate PPG-3 isosteareth-9

PEG- 150 distearate, P. lanolin PPG-3 PEG-6 oleylether

PEG-150 laurate, P. oleate PPG-5-buteth-7

PEG-150 stearate PPG-5-ceteth-20 PEG-200 castor oil PPG-5-ceteth-10 phosphate

PEG-200 glyceryl stearate PPG-8 oleate

PEG-200 hydrogenated castor oil PPG-10 cetyl ether phosphate

PEG-200 laurate, P. oleate PPG-12-PEG-50 lanolin

PEG-400 laurate PPG- 15 stearyl ether Phosphate esters PPG-24-buteth-27

Phosphated amine oxides PPG-25 laureth-25

Phospholipids PPG-26-buteth-26

Poloxamer 101, 105, 122, 123, 124 PPG-26 oleate

Poloxamer 181, 182, 184, 185, 235, 237 PPG-36 oleate Poloxamer 238, 334, 338, 407 Propylene glycol alginate, P.g. dioleate

Polyglyceryl-2 oleate Propylene glycol hydroxystearate

Polyglyceryl-2 polyhydroxystearate Propylene glycol laurate, P.g. ricinoleate

Polyglyceryl-2 sesquiisostearate Propylene glycol ricinoleate SE

Polyglyceryl-2 stearate Propylene glycol stearate Polyglyceryl-2-PEG-4-distearate Propylene glycol stearate, SE

Polyglyceryl-2-PEG-4-stearate Quaternium-33

Polyblyceryl-3 diisostearate, P. dioleate Rapeseedamidopropyl ethyldimonium ethosulfate

Polyglyceryl-3 distearate Rice (Oryza sativa) bran wax

Polyglyceryl-3 methylglucose distearate Ricinoleamide DEA Polyglyceryl-3 oleate, P. polyricinoleate Ricinoleic acid

Polyglyceryl-3 stearate Saponins

Polyglyceryl-4 oleate, P. stearate Selenium protein complex

Polyglyceryl-6 dioleate, P. distearate Silicone quaternium-5, -6

Polyglyceryl-6 laurate, P. myristate Sodium acrylates vinyl isodecanoate Polyglyceryl-6 oleate, P. polyricinoleate crosspolymer

Polyglyceryl-6 stearate Sodium caproyl lactylate

Polyglyceryl-8 oleate Sodium carbomer

Polyglyceryl-10 decaoleate Sodium cetyl sulfate

Polyglyceryl-10 diisostearate Sodium C12-15 parefh-15 sulfonate Polyglyceryl-10 dioleate, P. dipalmitate Sodium isostearoyl lactylate

Polyglyceryl-10 distearate, P. isostearate Sodium laureth- 17 carboxylate

Polyglyceryl-10 laurate, P. linoleate Sodium lauroyl lactylate

Polyglyceryl-10 mixed fatty acids Sodium lauryl sulfate

Polyglyceryl-10 myristate Sodium nonoxynol-6 phosphate Polyglyceryl-10 oleate Sodium octyl sulfate

Polyglyceryl-10 pentastearate Sodium oleate

Polyglyceryl-10 stearate Sodium oleyl sulfate

Polyglyceryl-10 tetraoleate Sodium phosphate Sodium stearoyl lactylate Artemisia apiacea extract

Sorbeth-20 Brassica rapa-depressa extract

Sorbitan isostearate, S. laurate Caraway (Carum carvi) oil

Sorbitan oleate, S. palmitate Cardamon (Elettaria cardamomum) oil Sorbitan sesquiisostearate Clove (Eugenia caryophyllus) oil

Sorbitan sesquioleate, S. sesquistearate Eclipta alba extract

Sorbitan stearate, S. triisostearate Eucalyptus globulus oil

Sorbitan trioleate, S. tristearate Euphotorium fortunei extract

Soyamidopropyl dimethylamine Euterpe precatoria extract Soyamine Hierochloe odorata extract

Stearamide DEA Kadsura heteliloca extract

Stearamide DIBA-stearate Ligustram lucidum extract

Stearamidoethyl diethylamine Lysimachia foenum-graecum extract

Stearamidopropyl dimethylamine, lactate Melaleuca bracteata extract Stearamidopropyl PG-dimonium chloride Melaleuca hypercifolia extract phosphate Melaleuca symphyocarp extract

Stearamine Melaleuca uncinata extract

Stearamine oxide Melaleuca wilsonii extract

Steareth-2, -4, -6, -7, -10, -11 , -13 Nasturtium sinensis extract Steareth-2 phosphate Nelumbium speciosum extract

Steareth-15, -20, -21, -30, -100 Paulownia imperialis extract

Stearic acid Rosemary (Rosmarinus officinalis) oil

Sucrose cocoate, S. distearate Selinum spp. extract

Sucrose stearate Trichomonas japonica extract Sythetic beeswax Withania somniferum extract

Tallow glyceride, acetylated hydrogenated Yuzu oil

Tallowamide DEA Ziziphus jujuba extract

Tallowamidopropyl dimethylamine

Talloweth-6 Exfoliant Tetrasodium dicarboxyethyl stearyl Apricot (Prunus armeniaca) kernel powder sulfosuccinamide Glycolic acid

TEA-acrylates/acrylonitrogens copolymer Jojoba (Buxus chinensis) seed powder

Tissue extract Lactic acid Papain

Triceteareth-4 phosphate PEG 11 -Avocado Glycerides Trideceth-3, -5, -6, -7, -8 Willow (Salix alba) bark extract

Trideceth-9, -10, -12, -15

Tridecyl ethoxylate Fiber

Triethanolamine Corn (Zea mays) cob powder

Trilaureth-4 phosphate Nylon-66 Triolein Oat (A vena sativa) bran, meal

Trisodium HEDTA Rayon

Tristearin

Film former

Enzyme Acetylated lanolin Fermented vegetable Acrylates/hydroxyesters acrylates copolymer

Ganoderma lucidum oil Acrylate/octylarylamide copolymer

Lipase Acrylate copolymer alkylated

Papain polyvinylpyrrolidone

Soy (Glycine soja) protein Ammonium acrylates/acrylonitrogens copolymer Superoxide dismutase Betaglucan

Bladderwrack (Fucus vesiculosus) extract

Essentail oil Carboxymethylchitosan

Aesculus chinensis extract N,0-Carboxymethylchitosonium Chitosan lactate Souble wheat protein

Collagen TEA-acrylates/acrylonitrogens copolymer

Collagen phthalate Tosylamide/epoxy resin

Colloidal oatmeal Tricontanyl PVP

Desamido collagen Triethonium hydrolyzed collagen ethosulfate

Diisostearoyl trimethylolpropane siloxy silicate Wheat peptide

DMHF

Ethyl ester of hydrolyzed silk Fixative

Ethylcellulose Acrylates copolymer

Gellan gum Adipic acid/dimethylaminohydroxypropyl

Glycerin/diethylene glycol/adipate crosspolymer diethylene triamine copolymer

High beta-glucan barley flour AMP-acrylates copolymer

Hydrolyzed collagen Hydrolyzed zein

Hydrolyzed keratin Methacrylol ethyl betaine/acrylates copolymer

Hydrolyzed oat protein Methyl rosinate

Hydrolyzed pea protein Polyquaternium-4, -10, -29

Hydrolyzed reticulin PPG-20 methyl glucose ether

Hydrolyzed RNA Sodium polystyrene sulfonate

Hydrolyzed silk

Hydrolyzed soy protein Flavor (aroma)

Hydrolyzed wheat protein Benzaldehyde

Hydrolyzed wheat protein/dimethicone copolyol Caraway (Caram carvi) oil phosphate copolymer Cardamon (Elettaria cardamomum) oil Hydrolyzed wheat protein/PVP copolymer Cinnamon (Cinnamomum casia) oil Hydroxypropylcellulose Clove (Eugenia caryophyllus) oil Hydroxypropyltrimonium gelatin Ethyl vanillin Jojoba (Buxus chinensis) oil Eucalyptus globulus oil Lactoglobolin Flavor (aroma)

Myristoyl hydrolyzed collagen Glutamic acid Nitrocellulose Glycyrrhetinic acid

Oat (Avena sativa) extract, protein Glycyrrhizic acid Polyethylene, ionomer Glycyrrhizin, ammoniated Polyquaternium-6, -7, -11, -22, -39 Methyl salicylate Poly vinyl acetate, P. alcohol Orange (Citrus aurantium dulcis) oil

Peppermint (Mentha piperita) oil

PVM/MA decadiene crosspolymer Rosemary (Rosmarinus officinalis) oil

Sodium glycyrrhizinate

PVP/Dimethiconylacrylate/polycarbamyl/pol Thymol Vanillin yglycol ester PVP/dimethylaminoethylmethacrylate copolymer Foam booster PVP/dimethylaminoethylmethacrylate/ Alkyldimethylamine oxide polycarbamyl/polyglycol ester Babassuamidopropyl betaine PVP/eicosene copolymer Babassuamidopropylamine oxide PVP/hexadecene copolymer Caprylyl pyrrolione PVP/hydrolyzed wheat protein copolymer Carrageenan (Chondras crispus) Rice peptide Cocamide DEA, C. MIPA Sericin Cocamidopropyl betaine

Shea butter (Butyrospermum parkii) Cocamidopropyl dimethylamine lactate Shellac Cocamidopropyl hydroxysultaine

Sodium C12-15 pareth-7 sulfonate Coco-betaine Sodium hyaluronate Coco/oleamidopropyl betaine Souble collagen Cocoyl amido hydroxy sulfo betaine Souble keratin Cocoyl monoethanolamide ethoxylate DEA-hydrolyzed lecithin Myristamide DEA, M. MEA

Dimethyl lauramine Oleamide MEA

Disodium cocamido MEA-sulfosuccinate Palmitamide MEA

Disodium cocoamphodiacetate PEG-3 lauramide Disodium lauramido MEA-sulfosuccinate PEG-4 oleamide

Disodium laureth sulfosuccinate Ricinoleamide MEA

Lauramide MIPA Sesamide DEA

Lauramidopropyl betaine Wheat germamide DEA

Lauryl betaine Myristamidopropyl dimethylamine dimethicone Foamer copolyol phosphate Ammonium laureth sulfate

Myristamine oxide Ammonium laureth-5 sulfate

Octyldodecyl benzoate Ammonium laureth- 12 sulfate

Oleamide DEA, O. MIPA Ammomum lauryl sulfate, A.l. sulfosuccinate Oleyl betain Ammonium myreth sulfate

Palm kernelamide DEA Ammonium nonoxynol 4 sulfate

PEG-3 lauramine oxide Capryl caprylylglucoside

PPG- 15 stearyl ether benzoate Cetyl betaine

PEG-7000 Cocamide Sodium cocoamphoacetate Cocamidopropyl dimethylamine

Sodium cocoyl isethionate Cocamidopropyl dimethylamine lactate

Sodium laureth sulfate DEA-laureth sulfate

Sodium lauroyl wheat amino acids DEA lauryl sulfate

Sodium octoxynol-2 ethane sulfonate Decyl glucoside Soyamidopropyl betaine Disodium caproamphodiacetate

Tallowamide MEA Disodium caproamphodipropionate Disodium capryloamphodiacetate

Foam stabilizer Disodium cocoamphodipropionate

Babassuamidopropylamine oxide Disodium lauroamphodiacetate Behenamine oxide Disodium lauroamphodipropionate

Caprylyl pyrrolidone Disodium lauryl sulfosuccinate

Cetamine oxide Disodium oleamido MEA-sulfosuccinate

Cocamide DEA, C. MEA, C. MIPA Disodium oleamido MIPA-sulfosuccinate

Cocamidopropyl betaine Disodium PEG-4 cocoamido MIPA- Cocamidopropyl hydroxysultaine sulfosuccinate

Cocamidopropyl lauryl ether Isostearamidopropylamine oxide

Cocamidopropylamine oxide Lauryl glucoside

Cocamine oxide Methyl gluceth-20

Dihydroxyethyl C12-15 alkoxypropylamine oxide MEA-laureth sulfate Dihydroxyethyl cocamine oxide Mixed isopropanolamines myristate

Dihydroxyethyl tailowamine oxide MIPA-lauryl sulfate

Erucamidopropyl hydroxysultaine PEG-80 sorbitan laurate

Hydroxypropyl methylcellulose PEG lauryl ether sulfate

Isostearamide DEA Potassium cocoate, P. lauryl sulfate Lauramide DEA, L. MEA Quillaja saponaria extract

Lauramido propylamine oxide Sodium caproamphoacetate

Lauramine oxide Sodium capryloamphoacetate

Laureth- 10 Sodium capryloamphohydroxypropylsulfonate

Lauric-linoleic DEA Sodium cocoamphoacetate Lauroyl-linoleoyl diethanolamide Sodium cocoamphopropionate

Lauroyl-myristoyl diethanolamide Sodium C12-15 pareth-25 sulfate

Lauryl pyrrolidone Sodium C12-15 pareth-3 sulfonate

Linoleamide MEA Sodium C12-15 pareth-15 sulfonate Sodium C14-16 olefin sulfonate Ziziphus jujuba extract

Sodium deceth sulfate

Sodium laureth-2 sulfate Gellant

Sodium laureth-3 sulfate Acrylic acid/acrylonitrogens copolymer Sodium laureth-7 sulfate Agar

Sodium lauriminodipropionate Algin

Sodium laurylether sulfosuccinate Aluminum distearate, A. tristearate

Sodium lauryl sulfate, S.l. sulfoacetate Ammonium acrylates/acrylonitrogens copolymer

Sodium lauryl sulfosuccinate Behenic acid Sodium magnesium laureth sulfate Calcium alginate

Sodium myreth sulfate, S. myristyl sulfate Carbomer

Sodium trideceth sulfate Carboxymethylchitosan

Sodium tridecyl sulfate N , O-Carboxymethylchitosomum

TEA-dodecylbenzenesulfonate Carrageenan (Chondras crispus) TEA-laureth sulfate Ceresin

TEA-lauroyl collagen amino acids Cetearyl candelillate

TEA-lauroyl keratin amino acids Dibenzylidene sorbitol

TEA-lauryl sulfate Ethylene/acrylic acid copolymer

TEA-palm kernel sarcosinate Ethylene/VA copolymer Wheat germamidopropyl Detain Gellan gum

Yucca vera extract Hexanediol behenyl beeswax

Hydrogenated jojoba oil

Fragrance Hydrogenated jojoba wax

Chamaecyparis obtusa oil Hydroxystearic acid Orange (Citrus aurantium dulcis) oil Jojoba wax Peppermint (Mentha piperita) oil Laneth-5, -15 Phenethyl alcohol Montmorillonite

Myreth-3-octanoate

Fragrance solvent Octacosanyl stearate Benzyl benzoate Oleth-3 phosphate Diethyl phthalate Oleth-10 phosphate Triacetin Poloxamer 105, 123, 124, 185, 235 Triethyl citrate Poloxamer 237, 238, 338, 407

Polyethylene Fungicide Polyethylene, oxidized

Astrocaryum muramura extract Polyquaternium-31

Azadirachta indica extract Potassium alginate, P. chloride

Captan Sodium nonoxynol-6 phosphate

Diiodomethyltolylsulfone Sodium tailowate Ficus racemosa extract Synthetic beeswax

Hexetidine TEA-acrylates/acrylonitrogens copolymer

Ligusticum jeholense extract Tribehenin

Mauritia flexosa extract

Melaleuca symphyocarp extract Glosser Melia australasica extract C 18-36 acid glycol ester

Melia azadirachta extract Diphenyl dimethicone

Mushroom (Cordyceps sabolifera) extract Methyl gluceth-10

Mushroom (Coriolus versicolor) extract Octyldodecyl lactate

Sodium undecylenate Phenyl methicone, P. trimethicone Tea tree (Melaleuca alternifolia) oil Polyglyceryl-2 dioleate

Thiabendazole Polyisobutene

Undecylenamide MEA Polyisobutene/isohexapentacontahectane

Zinc undecylenate Polyisobutene/isooctahexacontane Polymethacrylamidopropyltrimonium chloride Dihydroxyethyl tailowamine oleate

PPG-10 methyl glucose ether Dimethicone

PPG-3 oleate Dimethicone copolyol acetate, D.c. almondate

Tea (Camellia sinensis) oil Dimethicone copolyol amine

Tribehenin Dimethicone copolyol bishydroxyethylamine

Dimethicon copolyol isostearate, D.c. laurate

Hair care Dimethicone copolyol olivate

Gentiana scabra extract Dimethicone hydroxypropyl trimonium chloride

Maidenhair fern extract Dimethyl lauramine dimer dilinoleate

Nicotinamide Dioleylamidoethyl hydroxyethylmonium

Nicotinic acid methosulfate

Paeonia lactiflorum extract Dipalmitoylethyl hydroxyethylmonium

Watercress (Nasturtium officinale) extract methosulfate Diphenyl dimethicone

Hair conditioner Ditallowdimonium chloride

Amino bispropyl dimethicone N-Dodecy 1-N , N-dimethyl-N-(dodecy 1 acetate)

Amodimethicone ammonium chloride

AMPD-isostearoyl hydrolyzed collagen Entada phaseoloides extract

Aqua Ichthammol Ethyl ester of hydrolyzed animal protein Babassu (Orbignya oleifera) oil Gelatin

Babassuamidopropalkonium chloride Ginseng hydroxypropyltrimonium chloride

Behenamidopropyl dimethylamine butylene glycol

Behenamidopropyl hydroxyethyl dimonium Hematin chloride Honey (Mel) Behentrimonium chloride Hydrolyzed collagen

Biotin Hydrolyzed hair keratin

Bishydroxyethyl biscetyl malonamide Hydrolyzed vegetable protein

Borageamidopropyl phosphatidyl PG-dimonium Hydrolyzed wheat protein/dimethicone copolyol chloride acetyl copolymer Brazil nut (Bertholettia excelsa) oil Hydrolyzed wheat protein hydroxypropyl

Cetearyl trimonium methosulphate polysiloxane

Cetrimonium bromide, C. chloride Hydroxyethyl cetyldimonium phosphate

Cetyl pyridinium chloride Hydroxypropyl trimonium hydrolyzed collagen

Chia (Salvia hispanica) oil Hydroxypropyl trimonium hydrolyzed wheat Chrysanthemum morifolium extract protein polysiloxane copolymer

Cinchona succirabra extract Hyssop (Hyssopus officinalis) extract

Cocamidopropyl dimethylamine propionate Inga edulis extract

Coccinea indica extract Isostearamidopropylamine oxide

Cocodimonium hydroxypropyl hydrolyzed Isostearoyl hydrolyzed collagen collagen Keratin amino acids

Cocodimonium hydroxypropyl hydrolyzed Kiwi (Actinidia chinensis) frait extract keratin Kola (Cola acuminata) extract

Cocodimonium hydroxypropyl silk amino acids Laminaria japonica extract

Cocodimonium hydroxypropyl hydrolyzed wheat Laurtrimonium chloride protein Lauryl hydroxypropyl trimonium polysiloxane

Cocodimonium hydroxypropyloxyethyl cellulose copolymer

Cocotrimonium chloride Lauryldimethylamine isostearate

Collagen amino acids Lauryldimonium hydroxypropyl hydrolyzed

Cyclomethicone collagen L-cysteine HCL Lauryldimonium hydroxypropyl hydrolyzed

Dibehenyldimonium methosulfate wheat protein

Dicetyldimonium chloride Linoleamidopropyl dimethylamine dimer

Dicocodimonium chloride dilinoleate Linoleamidopropyldimethy lamine Tallowbenzy ldimethy lammonium chloride ,

Lysimachia foenum-graecum extract hydrogenated

Melaleuca hypercifolia extract Tallowtrimonium chloride

Ocimum santum extract Tea (Camellia sinensis) oil Olealkonium chloride TEA-cocoyl hydrolyzed soy protein

Oleyl dimethylamidopropyl ethonium ethosulfate Thenoyl methionate

Palmitamidodecanediol Trimethylsilylamodimethicone

Panthenyl ethyl ether Wheat amino acids

Paulownia imperialis extract Peach (Prunus perisca) leaf extract

PEG-2 cocomonium chloride

PEG-120 jojoba acid/alcohol

PG-hydroxycellulose lauryldimonium chloride

PG-hydroxyethylcellulose cocodimonium chloride

PG-hydroxyethylcellulose lauryldimonium chloride

PG-hydroxyethylcellulose stearyldimonium chloride Phenyl trimethicone

Phospholipids

Phytantriol

Polyoxyethylene polyoxypropylene glycol

Polypropylene glycol Polyquaternium-4, -6, -7, -10

Polyquaternium-22, -28, -39

PPG-5-ceteth-10 phosphate

Propyltrimonium hydrolyzed collagen propyltrimonium hydrolyzed soy protein Quaternium-18, -75, -81, -82

Quaternium-79 hydrolyzed keratin

Quaternium-79 hydrolyzed silk

Sambucus nigra extract, oil

Sesamidopropalkonium chloride Silicone quaternium-1, -8

Sodium cocoamphoacetate

Sodium cocoyl hydrolyzed collagen

Sodium polystyrene sulfonate

N-Soya-(3-amidopropyl)-N,N-dimethyl-N-ethyl ammonium ethyl sulfate

Steapyrium chloride

Stearalkonium chloride

Stearamidopropyl dimethylamine

Steardimomum hydroxypropyl hydrolyzed wheat protein

STeartrimonium chloride

Steartrimonium hydroxyethyl hydrolyzed collagen

N-Stearyl-(3-amidopropyl)-N,N-dimethyl-N-ethyl ammonium ethyl sulfate

Stenocalyx micalii extract

Sulfur Hair set resin polymer Humectant

Acrylates/acrylamide copolymer Acetamide MEA

Acrylafes/PVP copolymer Acetyl monoethanolamine

Acrylates/hydroxyesters acrylates copolymer 6-(N-Acetylamino)-4-oxyhexyltrimonium Acrylates/octylarylamide copolymer chloride

AMP-acrylates coppolymer Adenosine phosphate

Butylester of PVM-MA copolymer Ammonium lactate

Carboxylated vinylacetate terpolymer Atelocollagen

Diglycol/CHDM/isophthalates/SIP copolymer Calcium pantothenate Eclipta alba extract Calcium stearoyl lactylate

Ethyl ester of PVM/MA copolymer Carboxymethyl chitin

Hydroxypropyl chitosan Carboxymethyl chitosan succinamide

Isopropyl ester of PVM/MA copolymer Chitosan PCA

Octylacrylamide/acrylates/butylaminoethyl Cholesteryl hydroxystearate methacrylate copolymer Collagen amino-polysiloxane hydrolyzate

Polymethacrylamidopropyltrimonium chloride Colloidal oatmeal

Polypropylene glycol oligosuccinate Copper PCA methylsilanol

PVP Dimethicone copolyol laurate

PVP/dimethylaminoethylmethacrylate copolymer Dipotassium glycyrrhizinate PVP/Polycarbamyl polyglycol ester Ethyl ester of hydrolyzed silk

PVP/VA copolymer Fatty quaternary amine chloride complex

PVP/VA vinyl propionate copolymer Glucos glutamate

Sodium polyacrylate Glycereth-4,5-lactate

VA/butyl maleate/isobomyl acrylate copolymer Glycereth-7, -12, -26 VA/crotonates/vinyl neodecanoate copolymer Glycerin

VA/crotonates/vinyl propionate copolymer Honey extract

VA/crotonates copolymer Hydrogenated passion frait oil

Vinyl caprolactam/PVP/ Hydrolyzed casein dimethylaminoethylmethacrylate copolymer Hydrolyzed fibronectin

Hydrolyzed glycosaminoglycans

Hair sheen Hydrolyzed oat protein

Maidenhair fern extract Hydrolyzed silk

Tetrabutoxypropyl methicone Hydrolyzed soy protein

Hydroxypropyl chitosan Hair waving Hydroxypropyltrimonium hydrolyzed casein

Ammonium thioglycolate, A. thiolactate Hydroxypropyltrimonium hydrolyzed silk

Argania spinosa oil Hydroxypropyltrimonium hydrolyzed soy protein

L-cysteine HCL Hydroxypropyltrimonium hydrolyzed wheat

Cystine protein Diammonium dithiodiglycolate Keratin amino acids

Dilauryl thiodipropionate Lactamide DGA, MEA

Ethanolamine sulfite, E. thioglycolate Lactamidopropyl trimonium chloride

Ethanolamine thiolactate Lactic acid

Glyceryl thioglycolate Lactose Hydroxymethyl dioxoazabicyclooctane Lauroyl lysine

Jojoba esters Maltitol

Monoethanolamine thiolactate Mannitol

Shea butter, ethoxylated Methyl gluceth-10, -20

Sodium thioglycolate Natto gum Thioglycerin Oat (Avena sativa) extract, protein

Thioglycolic acid Panthenol

Thiolactic acid Panthenyl ethyl ether

PCA PEG-4 Methyl myristate, M. palmitate

Polyamino sugar condensate Oleic acid

Potassium lactate Ricinoleic acid

Propylene glycol Tall oil accid Propyltrimonium hydrolyzed collagen Tallow acid propyltrimonium hydrolyzed soy protein

Propyltrimonium hydrolyzed wheat protein Lathering agent

Quateraium-22 Ammonium cocoyl sarcosinate

Rice (Oryza sativa) germ oil Ammonium C12-15 alkyl sulfate Sea Salts (Maris sal) Ammonium lauroyl sarcosinate

Shea butter (Butyrospermum parkii) Cocamide MEA ethoxylate

Silk powder Cocamidopropyl dimethylammohydroxypropyl

Sodium behenoyl lactylate hydrolyzed collagen

Sodium caproyl lactylate Lauroyl sarcosine Sodium cocoyl lactylate Myristoyl sarcosine

Sodium hyaluronate Sodium cocoyl sarcosinate

Sodium isostearoyl lactylate Sodium lauroyl sarcosinate

Sodium lactate, S. lauroyl lactylate, S. PCA Sodium methyl cocoyl taurate

Sodium polyglutamate Sodium myristoyl sarcosinate Sodium stearoyl lactylate TEA-cocoyl sarcosinate

Sorbitan laurate TEA-lauroyl sarcosinate

Sorbitan sesquiisostearate

Sorbitol Lubricant

Sphingolipids Aluminum salt octenyl succinate TEA-PCA Amodimethicone

Urea Boron nitride

Calcium aluminum borosilicateCalcium stearate

Hvdrotrope Caprylic/capric triglyceride

Ammonium cumenesulfonate Coceth-7 carboxylic acid Ammonium xylenesulfonate Coconut (Cocos nucifera) oil

Cetamine oxide Cyclomethicone

Cocamidopropylamine oxide Diisodecyl adipate

Lauramine oxide Diisostearyl fumarate

Potassium toluenesulfonate Dimethyicone coppolyol PPG-2-isodeceth-4, -6, -9, -12 Glyceryl isostearate, G. oleate

Sodium cumene sulfonate Glyceryl polymethacrylate

Sodium laureth- 13-carboxylate Gold of Pleasure oil

Sodium toluene sulfonate Hyaluronic acid

Sodium xylene sulfonate Hydrogenated coconut oil Trideceth-19-carboxylic acid Hydrogenated cottonseed oil

Hydrogenated palm oil

Intermediate Hydrogenated soybean/cottonseed oil

Caprylic acid Hydrogenated soybean oil

Deceth-3 Hydrogenated vegetable oil Diethyl succinate Hydrolyzed oat flour

Dimethylaminopropylamine Hydroxypropyl guar

DM hydantoin Isodecyl stearate

Dodecylbenzene sulfonic acid Isopropyl lanolate

Ethylene dichloride Isostearyl diglyceryl succinate 4-Fluoro 3-nitro aniline Jojoba esters

Lauramine Lanolin oil

Methyl benzoate, M. cocoate Laurefh-3 phosphate

Methyl isostearate, M. laurate Magnesium myristate, M. stearate Mango (Mangifera indica) oil Triolein

Mineral oil (Paraffmum liquidum) Trisodium HEDTA

Minik'oil Triundecanoin

Monostearyl citrate Zinc laurate, Z. stearate Neatsfoot oil

Oleostearine Miscellaneous

Partially hydrogenated soybean oil Adhesion promoter — Glycerin diethylene glycol/

PEG-2 stearate adipate crosspolymer

PEG-4 dilaurate Analgesic — Glycol salicylate PEG-5M Anesthetic — Benzocaine

PEG-9M Anti-elastic — Hydrolyzed Ulva lactuca extract

PEG-23M Anti-itching — Sodium shale oil sulfonate

PEG-27 lanolin Antiacid — Magnesium hydroxide, Magnesium

PEG-30 lanolin silicate, Simethicone PEG-40 lanolin, P. stearate Antifoam — Dimethicone silylate, Simethicone

PEG-45M Antilipasic — Laminaria saccharina extract

PEG-90M Antipruritic — Coal tar

PEG-160M Antispasimodic — Garlic (Allium sativum) extract

PEG/PPG- 17/6 copolymer Anti-wrinkle — Chinese hibiscus (Hibiscus rosa- Pentaerythrityl tetrapelargonate sinensis) extract

Petrolatum Barrier — Glycerin/diethylene glycol/adipate

Phenethyl dimethicone crosspolymer

Phenyl methicone Cell regeneration — Glycoproteins, Hydrolyzed

Polyacrylamidomethylpropane sulfonic acid Ulva lactuca extract Polybutane Co-emulsifier —

Polydimethicone copolyol Cholesteryl/behenyl/octyldodecyl lauroyl

Polyglycerol ester of mixed vegetable fatty acids glutamate, Isododecane

Polymethylsilsesquioxane Colloid — Gelatin

Potassium laurate, P. myristate Cooling agent — Menthyl PCA, Menthone Potassium tailowate glycerin acetal

PPG-2 myristyl ether propionate Detoxifier — Clover (Trifolium pratense) extract

PPG-3 myristyl ether Dye stabilizer — Uric acid

PPG-9-buteth-12 Filler — Mica

PPG- 11 stearyl ether Fragrance stabilizer — 2,2', 4,4'- PPG-12-buteth-16 Tetrahydroxybenzophenone

PPG-12-PEG-50 lanolin Free radical scavenger — Melanin

PPG- 14 butyl ether IR filter — Corallina officinalis

PPG-20 cetyl ether Lanolin substitute — PEG-80 jojoba acid/alcohol

PPG-20-buteth-30 Lipolytic — Gelidium cartilagineum PPG-24-buteth-27 Oxident — Barium peroxide, Hydrogen peroxide,

PPG-28-buteth-35 Urea peroxide

PPG-36 oleate Oxygen carrier — Perfluorodecalin

PPG-40 butyl ether Peroxide stabilizer — Phenacetin, Sodium

Quaternium-79 hydrolyzed keratin stannate Quaternium-79 hydrolyzed silk Scalp stimulant — Birch (Betula alba) leaf extract

Rice (Oryza sativa) starch Sebostatic — Laminaria saccharina extract

Shea butter (Butyrospermum parkii) extract Shine enhancer — Hydrolyzed wheat protein

Shorea stenoptera butter hydroxypropyl polysiloxane

Silica Skin barrier lipid — Ceramide 3, N(27- Stearamide MEA, S. MEA-stearate Stearoyloxy-heptacosanoyl) phytosphingosine

Stearoxytrimethylsilane Skin clarifier — Oat (A vena sativa) bran extract

Stearyl dimethicone Skin purifier — Birch (Betula alba) leaf extract

Triisostearyl citrate Substantivity — Dimethicone copolyol Bactri gasipaes extract bishydroxyethylamine, Dimethicone Benincasa hispids extract hydroxypropyl trimonium chloride, Betaglucan Trimethylsilylamodimethicone Betaine Sunless tanning — Acetyl tyrosine, Eclipta alba Borage (Borago officinalis) seed oil extract in white emulsion Brazil nut (Bertholettia excelsa) extract, oil

Tonic — Kiwi (Actinidia chinensis) frait extract, C 10-30 cholesterol/lanosterol esters Matricaria (Chamomilla recutita) extract, Calcium pantothenate Orange (Citrus aurantium dulcis) peel extract Calcium protein complex Viscosity stabilizer — Diisodecyl adipate Caprylic/capric triglyceride

Spreading agent — Stearyl heptanoate Caprylic/capric/lauric triglyceride

Wound healing — Comfrey (Symphytum Caprylic/capric/linoleic triglyceride officinale) leaf extract Caprylic/capric/oleic triglycerides

Waterproofing agent — PVP/eicosene copolymer, Cashew (Anacardium occidentale) nut oil PVP/hexadecene copolymer, Tricontanyl Celastras paniculata extract

PVP Ceramide 33 (liquid soy extract)

Chia (Salvia hispanica) oil

Moisture barrier Chinese hibiscus (Hibiscus rosa-sinensis) extract

Acrylates/octylarylamide copolymer Chitin Betaglucan Chitosan, C. PCA

C16-18 alkyl methicone Cholesteric esters

Cholesterol Cholesterol

Glycolipids Cholesteryl/behenyl/octyldodecyl lauroyl

Isoeicosane glutamate Isohexadecane Cocodimonium hydroxypropyl hydrolyzed

Lanosterol collagen

Octyl pelargonate, O. stearate Cocodimonium hydroxypropyl hydrolyzed silk

Polyisobutene Cocodimonium hydroxypropyl hydrolyzed wheat

Polyisobutene/isohexapentacontahectane protein Polyisobutene/isooctahexacontane Cocodimonium hydroxypropyl silk amino acids

Silica silylate Collagen

Trihydroxypalmitamidohydroxy propyl myristyl Collagen amino acids, C. phthalate ether Copper aspartate, C. protein complex

Trimethylsiloxysilicate Corn (Zea mays) oil Cottonseed (Gossyplum) oil

Moisturizer Crataegus cuneata extract

Acetamidopropyl trimonium chloride Cucumber (Cucumis sativus) extract

Adenosine triphosphate Desamido collagen

Aesculus chinensis extract Dicaprylyl maleate Algae (Ascophyllum nodosum) extract Diisocetyl dodecanedioate

Algae extract Diisostearyl adipate

Aloe barbadensis, A.b. extract Dimethyl hyaluronate

Ammonium lactate Dimethylsilanol hyaluronate

Amniotic fluid Dioctyldodecyl dimer dilinoleate Apple (Pyras malus) extract Dioctyldodecyl dodecanedioate

Apricot (Prunus armeniaca) kernel oil Dipentaerythritol fatty acid ester

Arginine PCA Dog rose (Rosa canina) hips extract

Atelocollagen Dog rose (Rosa canina) seed extract

Artemisia apiacea extract Echitea glauca extract Astrocryum murumura extract Elastin amino acids

Avocado (Persea gratissima) extract, oil Emblica officinalis extract

Avocado (Persea gratissima) unsaponifiables Ethyl minkate

Babassu (Orbignya oleifera) oil Eugenia jambolana extract Evening primrose (Oenothera biennis) extract, oil Lactamide DGA, L. MEA

Galla sinensis extract Lactic acid

Ganoderma lucidum oil Lactobacillus/whey ferment

Ginseng (Panax ginseng) extract Lactococcus hydrolysate Gleditsia sinensis extract Lactoyl methylsilanol elastinate

Glycereth-12 Lanolin alcohol

Glyceryl alginate, G. collagenate Lauryl PCA

Glyceryl polymethacrylate Lecithin

Glycolic acid Lesquerella fendleri oil Glycolipids Liposomes

Glycosaminoglycans Lysine PCA

Glycosphingolipids Macadamia ternifolia nut oil

Gnetum amazonicum extract Magnesium aspartate

Grape (Vitis vinifera) seed oil Maltitol Hazel (Corylus avellana) nut oil Manganese aspartate

Honey extract Mango (Mangifera indica) oil

Hyaluronic acid Mannan

Hybrid safflower (Carthamus tinctorius) oil Marine polyaminosaccharide

Hydrogenated castor oil Mauritella armata extract Hydrogenated coconut oil Maximilliana regia extract

Hydrogenated cottonseed oil Meadowfoam (Limnanthes alba) seed oil

Hydrogenated lecithin Melaleuca hypercifolia extract

Hydrogenated palm oil Methylsilanol elastinate, M. mannuronate

Hydrogenated polyisobutene Milk amino acids Hydrogenated soybean oil Mineral oil (Paraffinum liquidum)

Hydrogenated soybean/cottonseed oil Molybdenum aspartate

Hydrogenated vegetable oil Mouriri apiranga extract

Hydrolyzed carbolipoprotein Natto gum

Hydrolyzed collagen Nelumbium speciosum extract Hydrolyzed elastin Neopentyl glycol dicaprate

Hydrolyzed fibronectin Oat (Avena sativa) protein

Hydrolyzed glycosaminoglycans Octyl hydroxystearate hydrolyzed keratin Ophiopogon japonicus extract

Hydrolyzed milk protein Orange (Citrus aurantium dulcis) peel wax Hydrolyzed oats Palmetto extract

Hydrolyzed pea protein Pantethine

Hydrolyzed placental protein Panthenyl ethyl ether

Hydrolyzed rice protein Paraffin

Hydrolyzed transgenic collagen Partially hydrogenated soybean oil Hydrolyzed serum protein peanut (Arachis hypogaea) oil

Hydrolyzed silk Pecan (Carya illinoensis) oil

Hydrolyzed sweet almond protein PEG-4, -6, -8, -12

Hydrolyzed wheat protein PEG-70 mango glycerides

Hydroxyethyl chitosan PEG-75 shea butter glycerides Inositol PEG-75 shorea butter glycerides

Isodecyl salicylate PEG- 100 stearate

Isostearyl hydrolyzed animal protein Pentaerythrityl

Jojoba (Buxus chinensis) oil isostearate/caprate/caprylate/adipate

Jojoba esters Pentaerythrityl stearate/caprate/caprylate/adipate Keratin amino acids Pentylene glycol

Kiwi (Actinidia chinensis) frait extract Perfluoropolymefhylisopropyl ether

Kola (Cola acuminata) extract Petrolatum

Kukui (Aleurites molaccana) nut oil Petroleum wax Pfaffia spp. extract Wheat (Triticum vulgare) germ extract, germ oil

Pistachio (Pistacia vera) nut oil Yarrow (Achillea millefolium) extract

Placental protein Wheat amino acids

Plankton extract Yeast (Saccheromyces cerevisiae) extract (Faex) Polyamino sugar condensate Yogurt filtrate

Polybutene Zinc aspartate

Polyunsaturated fatty acids Ziziphus jujuba extract

Potassium DNA, P. lactate, P. PCA

PPG-8/SMDI copolymer Naturilizer PPG-20 methyl glucose ether distearate 2-Aminobutanol

Propylene glycol dicaprylate/dicaprate Aminoethyl propanediol

Propylene glycol dioctanoate Aminomethyl propanediol

Pumpkin (Cucurbita pepo) seed oil Aminomethyl propanol

Quinoa (Chenopodium quinoa) extract Ammonium carbonate Rapeseed (Brassica campestris) oil Calcium hydroxide

Rehmannia chinensis extract Diethanolamine

Rice (Oryza sativa) bran oil Ethanolamine

Rose Water Glucamine

Royal jelly extract Isopropanolamine Saccharide isomerate Isopropylamine

Saccharomyces lysate extract 2-Methyl-4-hydroxypyrrolidine

Saccharomyces/soy protein ferment Morpholine

Safflower (Carthamus tinctorius) oil Sodium bromate

Selenium aspartate, S. protein complex Succinic acid Sericin Tetrahydroxypropyl ethylenediamine

Serum albumin Triethanolamine

Sesame (Sesamum indicum) oil Tromethamine

Shea butter (Butyrospermum parkii)

Shea butter (Butyrospermum parkii) extract Oil absorbent Shorea stenoptera butter Hydrated silica

Silk amino acids Polymethyl methacrylate

Sodium carboxymethyl beta-glucan Silicon dioxide hydrate

Sodium chondroitin sulfate Walnut (Juglans regia) shell powder

Sodium DNA, S. hyaluronate Sodium lactate, S. PCA Ointment base

Souble collagen Borage (Borago officinalis) seed oil

Souble transgenic elastin Caprylic/capric/stearic triglyceride

Soybean (Glycine soja) oil Glyceryl cocoate

Spherical cellulose acetate Hydrogenated coco-glycerides Spondias amara extract Lanolin

Squalene Mink oil

Stomach extract Oleostearine

Sunflower (Helianthus annuus) seed oil Tallow

Superoxide dismutase Tissue extract Opacifier

Tocopheryl acetate, T. linoleate Barium sulfate

Tomato (Solanum lycopersicum) extract C12-16 alcohols

Tormentil (Potentilla erecta) extract Cetearyl octanoate

Trehalose Cetyl myristate, C. palmitate Triundecanoin Cocamidopropyl lauryl ether

Vegetable oil Glyceryl distearate

Walnut (Juglans regia) oil Glyceryl hydroxystearate

Watercress (Nasturtium officinale) extract Glyceryl myristate, G. stearate Glycol distearate, G. stearate Rice (Oryza sativa) bran wax

Magnesium myristate Serum protein

PEG-2 distearate, P. stearate Tosylamide/epoxy resin

PEG-2 stearate SE Triacetin PEG-3 distearate Tributyl citrate

Propylene glycol myristate, P.g. stearate Triethyl citrate

Stearamide Trimethyl pentanediol dibenzoate

Stearamide DIBA-stearate Trimethylethanetribenzoate

Stearamide MEA Stearamide MEA-stearate Polish

Stearamidopropyl dimethylamine lactate Acrylates copolymer

Stearyl stearate Aluminum silicate

Styrene homopolymer Neatsfoot oil

Styrene/acrylates copolymer Tallow Styrene/PVP copolymer

Triisostearin PEG-6 esters Polymer

Acrylamide sodium acrylate copolymer

Plasticizer Acrylates- VA crosspolymer

Acetyl tributyl citrate Acrylates/acrylamide copolymer Acetyl triethyl citrate Acrylates/hydroxyesters acrylates copolymer

AMP-isostearoyl hydrolyzed wheat protein Acrylates/octylacrylamide copolymer

AMPD-isostearoyl hydrolyzed collagen Acrylates/steareth-20 methacrylate copolymer

Cyclohexane dimethanol dibenzoate Adipic acid-epoxypropyl diethylenetriamine

Dibutyl phthalate copolymer Diethyl phthalate Adipic acid/dimethylaminohydroxypropyl

Diethylene glycol dibenzoate diethylene triamine coppolymer

Diisopropyl sebacate Ammonium acrylates copolymer

Dimethicone copolyol Ammonium acrylates/acrylonitrogens copolymer

Dimethyl phthalate AMP-acrylates copolymer Dipropylene glycol dibenzoate AMP-isostearoyl hydrolyzed collagen

Ethyl ester of hydrolyzed keratin Butylester of PVM-MA copolymer

Glycerol tribenzoate Calcium carrageenan

Glycol Carboxylated vinylacetate terpolymer

Hydrolyzed serum protein Ceteareth-2 phosphate Isocetyl salicylate Ceteareth-5 phosphate

Isodecyl benzoate Ceteareth-10 phosphate

Isoeicosane Ceteareth-29, -34

Isopropyl lanolate Coco-glucoside

Isostearoyl hydrolyzed collagen Cocodimonium hydroxypropyloxyethyl cellulose Lauroyl hydrolyzed collagen C12-13 pareth-4, -9, -23

Marine collagen DEA-ceteareth-2-phosphate

Monostearyl citrate DEA-oleth-5-phosphate

Neopentyl glycol dibenzoate DEA-oleth-20-phosphate

Octyl benzoate, O. laurate Diglycol/CHDM/isophthalates/SIP copolymer PEG-60 shea butter glycerides Diisopropyl dimer dilinoleate

Pentaerythrityl tetrabenzoate Diisostearoyl trimethylolpropane siloxy silicate

Polyoxyethylene glycol dibenzoate Diisostearyl dimer dilinoleate

Polypropylene glycol dibenzoate Dilinoleic acid

PPG-12-PEG-50 lanolin Dodecanedioic acid/cetearyl alcohol/glycol PPG-20 cetyl ether copolymer

PPG-20 lanolin alcohol ether Eclipta alba extract

Propylene glycol dibenzoate Ethyl ester of PVM/MA copolymer

Propylene glycol myristyl ether acetate Ethylene/acrylic acid copolymer Ethylene/VA copolymer Polyglyceryl-2 polyhydroxystearate

Glycereth-26 phosphate Polymethacrylamidopropyltrimonium chloride

Hyaiufonic acid Polyquaternium-6, -7, -10, -11, -22, -39

Hydrolyzed RNA Polysilicone-8 Hydrolyzed wheat protein polysiloxane polymer Potassium alginate

Hydroxypropyltrimonium hydrolyzed collagen Potassium lauroyl collagen amino acids

Hydroxypropyltrimonium hydrolyzed wheat Potassium lauroyl hydrolyzed soy protein protein Potassium lauroyl wheat amino acids

Laneth-40 PPG-8/SMDI copolymer Lauryldimonium hydroxypropyl hydrolyzed soy PPG-12/SMDI copolymer protein PPG-51/SMDI copolymer

Methacrylol ethyl betaine/acrylates copolymer PVM/MA decadiene crosspolymer

Octylacrylamide/acrylates/butylaminoethyl PVP/dimethylaminoethylmethacrylate copolymer methacrylate copolymer PVP/VA copolymer Oleth-2 phosphate Sodium cocoyl hydrolyzed wheat protein

Oleth-5 phosphate Steardimomum hydroxypropyl hydrolyzed wheat

PEG-3 lanolate protein

PEG-4 stearate Steareth-2 phosphate

PEG-5M TEA-acrylates/acrylonitrogens copolymer PEG-7 glyceryl cocoate Tosylamide/epoxy resin

PEG-8 glyceryl laurate Tosylamide/formaldehyde resin

PEG-8/SMDI copolymer Trideceth-5, -6, -7, -8

PEG-9 castor oil VA/butyl maleate/isobomyl acrylate copolymer

PEG-9M VA/crotonates/vinyl neodecanoate copolymer PEG- 11 babassu glycerides Vinyl caprolactam/PVP/

PEG-12 palm kernel glycerides dimethylaminoethylmethacrylate copolymer

PEG-12 stearate Wheat (Triticum vulgare) protein

PEG- 14 avocado glycerides Xanthan gum

PEG-15 glyceryl laurate PEG-20 corn glycerides Powder

PEG-20 evening primrose glycerides Acrylates copolymer, spherical powder

PEG-20 glyceryl oleate Attapulgite

PEG-23 oleate Boron nitride

PEG-23M Calcium aluminum borosilicate PEG-29 castor oil Calcium carbonate

PEG-42 babassu glycerides Cellulose triacetate

PEG-45 safflower glycerides Com (Zea mays) cob powder, starch

PEG-45M Hydrogenated jojoba wax

PEG-60 evening primrose glycerides Magnesium carbonate, M. myristate PEG-60 hydrogenated castor oil Magnesium stearate

PEG-75 castor oil Mica

PEG-90M Microcrystalline cellulose

PEG- 120 distearate Nylon-6

PEG-150 lanolin Nylon powder PEG-160M Oat (Avena sativa) starch

PG-hydroxycellulose lauryldimonium chloride Poly amide 12

PG-hydroxyethylcellulose cocodimonium Polyethylene chloride Polymethyl methacrylate

PG-hydroxyethylcellulose stearyldimonium Polymethylsilsesquioxane chloride PTFE

Polyethylene, ionomer Silica

Polyethylene, micronized Silk powder

Polyethylene, oxidized Spherical cellulose acetate Talc Methyl paraben sodium

Tapioca dextrin Methylchloroisothiazolinone

Zinc laurate Methyldibromo glutaronitrile

Methylisothiazolinone

Powder, absorbent Methylparaben

Aluminum starch octenylsuccinate Mushroom (Cordyceps sabolifera) extract Clays (white, yellow, red, green, pink) Myrtrimonium bromide Sorbitol Pentasodium pentetate Tapioca Pentetic acid

Phenethyl alcohol

Preservative Phenol

Alcohol Phenyl mercuric acetate

Ascorbic acid o-Phenylphenol

Ascorbyl palmitate Polyaminopropyl biguanide

Benzalkonium chloride Polymethoxy bicyclic oxazolidine

Benzethonium chloride Potassium sorbate

Benzoic acid Propylparaben

Benzyl alcohol Quaternium-15

Benzylparaben Salicylic acid

5-Bromo-5 nitro-l ,3-dioxane Sodium benzoate, S. bisulfate

2-Bromo-2-nitropropane- 1 ,2-diol Sodium butylparaben, S. dehydroacetate

Butylparaben Sodium erythorbate, S. ethyl paraben

Calcium propionate Sodium hydroxymethylglycinate

Cetrimonium bromide Sodium metabisulfite, S. methylparaben

Cetyl pyridinium chloride Sodium o-phenylphenate

Chloroxylenol Sodium propionate, S. propylparaben

Chlorphenesin Sodium pyrithione, S. salicylate o-Cymen-5-ol Sodium sulfite

Diazolindinyl urea Sorbic acid

Dichlorobenzyl alcohol Tetrasodium EDTA

Dichlorophene Thimerosal

Diiodomethyltolylsulfone Thymol

Dimethyl hydroxymethyl pyrazole Tris (hydroxymethyl) nitromethane

Dimethyl oxazolidine Trisodium EDTA, T. HEDTA

Disodium EDTA Usnic acid

DMDM hydantoin Zinc PCA

EDTA

Erythoribc acid Propellant

7-Ethylbicyclooxazolidine Butane

Ethylparaben Dimethyl ether

Fomistopsis officinalis oil Hydrofluorocarbon 152a

Formaldehyde Isobutane

Glutaral Propane

Glyeryl laurate

HEDTA Protein

Hexamidine diisethionate Albumen

Hexetidine Atelocollagen

Imidazolidinyl urea Bletia hyacinthina extract

Isobutylparaben Chrysanthemum morifolium extract

Isopropyl sorbate Cocodimonium hydroxypropyl hydrolyzed

Isopropylparaben collagen

MDM hydantoin Cocodimonium hydroxypropyl hydrolyzed

Methenammonium chloride keratin Cocodimonium hydroxypropyl hydrolyzed soy Sodium stearoyl hydrolyzed collagen protein Sodium undecylenoyl hydrolyzed collagen

Cocόdfmonium hydroxypropyl hydrolyzed wheat Sodium/TEA-lauroyl hydrolyzed collagen protein Sodium/TEA-lauroyl hydrolyzed keratin Cocoyl hydrolyzed collagen Soluble collagen

Collagen, C. phthalate Soluble keratin

Collagen amino-polysiloxane hydrolyzate Soluble wheat protein

Deoxyribonucleic acid Soy (Glycine soja) protein

Desamido collagen Steardimomum hydroxypropyl hydrolyzed Elastin amino acids collagen

Embryo extract Steartrimonium hydroxyethyl hydrolyzed

Ethyl ester of hydrolyzed animal protein collagen

Fibronectin TEA-cocoyl hydrolyzed collagen

Gelatin TEA-cocoyl hydrolyzed soy protein Human placental protein TEA-lauroyl collagen amino acids

Hydrolyzed collagen TEA-lauroyl keratin amino acids

Hydrolyzed extensin Trachea hydrolysate

Hydrolyzed fish protein Triethonium hydrolyzed collagen ethosulfate

Hydrolyzed hemoglobin Wheat (Triticum vulgare) germ extract, protein Hydrolyzed keratin Wheat amino acids

Hydrolyzed lactalbumin Wheat peptide

Hydrolyzed milk protein Wheat protein

Hydrolyzed soy flour

Hydrolyzed sweet almond protein Protein, hvdrolvzed Hydroxypropyltrimonium hydrolyzed collagen Ethyl ester of hydrolyzed silk

Isostearoyl hydrolyzed collagen Hydrolyzed casein

Keratin Hydrolyzed elastin

Lactoferrin Hydrolyzed mushroom (Tricholoma matsutake)

Lactoglobolin extract Lauryldimonium hydroxypropyl hydrolyzed Hydrolyzed pea protein collagen hydrolyzed rice protein

Marine collagen Hydrolyzed serum protein

Methylsilanol elastinate Hydrolyzed silk

Potassium abietoyl hydrolyzed collagen Hydrolyzed soy protein Potassium cocoyl hydrolyzed collagen Hydrolyzed vegetable protein

Potassium myristoyl hydrolyzed collagen Hydrolyzed wheat protein

Potassium oleoyl hydrolyzed collagen Hydroxypropyltrimonium hydrolyzed casein

Potassium undecylenoyl hydrolyzed collagen Hydroxypropyltrimonium hydrolyzed silk

Propyltrimonium hydrolyzed collagen Hydroxypropyltrimonium hydrolyzed soy protein Propyltrimonium hydrolyzed soy protein Hydroxypropyltrimonium hydrolyzed wheat

Propyltrimonium hydrolyzed wheat protein protein

Protein hydroylsates

Quaternium-79 hydrolyzed keratin Reducing agent

Quaternium-79 hydrolyzed silk Dimyristyl thiodipropionate Rice peptide Hydrolyzed zein, iodized

RNA Hydrolyzed zein, sulfurized

Serum albumin, S. protein Zinc formaldehyde sulfoxylate

Silk powder

Sodium caseinate Refatting agent Sodium cocoyl hydrolyzed collagen Caprylic/capric triglyceride PEG-4 esters

Soidum cocoyl hydrolyzed soy protein Cocamide MIPA

Sodium myristoyl hydrolyzed collagen Diisostearyl dimer dilinoleate

Sodium oleoyl hydrolyzed collagen Hydrogenated palm kernel glycerides Isostearyl erucate, I. isostearate Dimethicone copolyolamine

Lecithin Dimethiconol fluoroalcohol dilinoleic acid

Liposomes Dimethiconol hydroxystearate, D. stearate

Magnesium sulfate hepta-hydrate Diphenyl dimethicone Octyldodecyl behenate, O. myristate Disodium-PG-propyldimethicone thiosulfate bis-Octyldodecyl stearoyl dimer dilinoleate Isopropyl hydroxybutyramide dimethicone

Octyldodecyl stearoyl stearate copolyol

Octyl hydroxystearate Methicone

PEG-3 stearate Octamethyl cyclotetrasiloxane PEG-4 oleamide Phenyl methicone, P. trimethicone

PEG-6 capric/caprylic glycerides Polyether Trisiloxane

PEG-7 glyceryl cocoate Polymethylsilsesquioxane

PEG- 16 Polysilicone-8

Propylene glycol dipelargonate Quaternium-80

Silicone quaternium-1, -8

Resin Sodium-PG-propyl thiosulfate dimethicone

Acrylates/hydroxyesters acrylates copolymer Stearoxymethicone/dimethicone copolymer

Ethylene vinyl acetate Trimethylsilylamodimethicone

Glyceryl abietate Methacrylol ethyl betaine/acrylates copolymer Skin calming agent

4-Methyl benzenesulfonamide Cornflower (Centaurea cyanus) extract

Polypropylene Fennel (Foeniculum vulgare) extract

Polyquaternium-16, -44 Fenugreek extract

Sucrose benzoate Linden (Tilia cordata) extract Valerian (Valeriana officinalis) extract

Sequestrant

Calcium acetate, C. phosphate, C. sulfate Skin cleanser

Encapsulation and entrapment systems Dog rose (Rosa canina) hips extract

Pentasodium triphosphate Papaya (Carica papaya) extract Phosphoric acid Peach (Prunus persica) extract

Potassium phosphate, P. sodium tartrate Rose (Rosa multiflora) extract

Silicon dioxide hydrate Willow (Salix alba) extract

Sodium citrate, S. gluconate

Sorbitol ' Skin conditioner Tartaric acid Artemisia apiacea extract

Tripotassium EDTA Astrocaryum tucuma extract

Trisodium NTA Bactris gasipaes extract

Biotin

Silicone Bishydroxyethyl biscetyl malonamide Amino bispropyl dimethicone Bletia hyacinthina extract

Ammonium dimethicone coplyol sulfate Borage (Borago officinalis) seed oil

Amodimethicone Borageamidopropyl phosphatidyl PG-dimonium

Behenoxy dimethicone chloride

C16-18 alkyl methicone Carbocysteine Cetyl dimethicone copolyol Catalpa kaempfera extract

Cyclomethicone Coco phosphatidyl PG-dimonium chloride

Diisodecyl adipate Cocodimonium hydroxypropyl hydrolyzed

Diisostearoyl trimethylolpropane siloxy silicate keratin

Dimethicone Collagen amino acids Dimethicone copolyol Cyclomethicone

Dimethicone copolyol almondate Dimethicone, D. copolyol acetate

Dimethicone copolyol isostearate Emblica officinalis extract

Dimethicone copolyol olivate, D.c. phthalate Equisetum arvense extract Ethyl ester of hydrolyzed animal protein Ascorbic acid polypeptide

Evening primrose (Oenothera biennis) oil Bearberry (Arctostaphylos uva-ursi) extract

Fomes'fometarius extract Hydroquinone-beta-D-glucopyranoside

Fomistopsis officinalis oil Lemon (Citras medica limonum peel extract Gelatin Pearls (Margarita margarita)

Ginseng hydroxypropyltrimonium chloride butylene glycol Skin protectant

Glycolipids Acetylmethionyl methylsilanol elastinate

Glycosphingolipids Allantoin, A. aluminum hydroxide Gnetum amazonicum extract Aloe barbadensis, A.b. extract

Honey (Mel) Aluminum starch octenylsuccinate

Hydrolyzed carbolipoprotein Anise (Pimpinella anisum) extract

Hydrolyzed elastin Arnica montana extract

Hydrolyzed pea protein Artemisia apiacea extract Hydrolyzed rice protein Ascorbyl methylsilanol pectinate

Hydrolyzed serum protein Astrocaryum tucuma extract

Hydrolyzed silk Bactris gasipaes extract

Hydrolyzed soy protein Betaglucan

Hydrolyzed vegetable protein Bishydroxyethyl biscetyl malonamide Hydrolyzed wheat protein Bletia hyacinthina extract

Inga edulis extract C18-70 Isoparaffin

Kiwi (Actinidia chinensis) frait extract Calendula amurrensis extract

Laminaria japonica extract Carboxymethyl chitin

Lecithin Carcinia cambogia extract Marsilea minuta extract Carrot (Daucus carota) extract

Nettle (Urtica dioica) extract Carrot (Daucus carota sativa) oil

Palmitamidodecanediol Catalpa kaempfera extract

Pearls (Margarita margarita) Chenopodium album extract

PEG-42 Ebiriko ceramides extract Chitosan Phenyl trimethicone Chrysanthemum morifolium extract

Phytantriol Collagen

Polygonum multiflorum extract Com poppy (Papaver rhoeas) extract

Crataegus cuneata extract

Crataegus monogina extract Potassium cocoyl hydrolyzed collagen Cypress (Cupressus sempervirens) extract

Retinyl palmitate polypeptide Dimethicone

Salvia miltiorrhiza extract Dimethiconol fluoroalcohol dilinoleic acid

Silt Dimethiconol hydroxystearate, D. stearate

Sodium cocoyl hydrolyzed collagen Dimethylsilanol hyaluronate Soluble transgenic elastin Echitea glauca extract

Steartrimonium hydroxyethyl hydrolyzed Embryo extract collagen Entada phaseoloides extract

Stearyl methicone Equisetum arvense extract

Euphotorium fortunei extract Skin healing Euterpe precatoria extract

Calendula officinalis extract Fenugreek extract Glycoproteins fomistopsis officinalis oil, F. pinicola extract

Hydrocotyl (Centella asiatica) extract Galla sinensis extract Oat (Avena sativa) extract Gentian (Gentiana lutea) extract Sandalwood (Santalum album) extract Gleditsia sinensis extract Spearamint (Mentha viridis) extract Glyceryl ricinoleate

Glycolipids

Skin lightening/whitening agent Hierochloe odorata extract Hyaluronic acid Xanthozylum bungeanum extract Hydrogenated lecithin Zinc oxide Hydrolyzed lupine protein Hydrolyzed milk protein Skin smoothing agent Hydrolyzed mushroom (Tricholoma matsutake) Althea officinalis extract extract Coltsfoot (Tussilago farfara) leaf extract

Comfrey (Symphytum officinale) leaf extract

Isodecyl salicylate Plantain (Plantago major) extract

Jojoba (Buxus chinensis) oil Sericin Lady's Thistle (Silybum marianum) extract

Laminaria japonica extract Skin softening

Ligusticum jeholense extract Clays (white, yellow, red, green, pink)

Liposomes Cucumber (Cucumis sativus) extract

Magnolis spp. extract Kelp (Macrocystis pyrifera) extract Mango kernel oil Peach (Prunus perisca) extract marsilea minuta extract Phenethyl dimethicone

Melaleuca hypercifolia extract

Melaleuca uncinata extract Skin soothing

Melaleuca wilsonii extract Calendula officinalis extract Methylsilanol tri PEG-8 glyceryl cocoate Cherry bark extract

Oat (Avena stiva) meal Cucumber (Cucumis sativus) extract

Oyster (Ostrea) shell extract Garlic (Allium sativum) extract

Palmitamidodecanediol Hyssop (Hyssopus officinalis) extract

Pearls (Margarita margarita) Jasmine (Jasminum officinale) extract Pentahydrosqualene Kelp (Macrocystis pyrifera) extract

Perluorodecalin Mango kernel oil

Perfluoropolymethylisopropyl ether Meadowsweet (Spiraea ulmaria) extract

Petrolatum Quince (Pyras cydonia) seed extract

PEG-8/SMDI copolymer Slippery elm extract PEG-42 Ebiriko ceramides extract Valerian (Valeriana officinalis) extract

Pfaffia spp. extract Willow (Salix alba) extract

Phospholipids Witch hazel (Hamamelis virginiana) extract

Plankton extract

Polygonum multifloram extract Pongamol Solubilizer

PPG-12/SMDI Copolymer Acetyl monoethanolamine

PPG-51/SMDI Copolymer Almond oil PEG-6 esters

Propyltrimonium hydrolyzed collagen 2-Aminobutanol

Quinoa (Chenopodium quinoa) extract, oil Aminoethyl propanediol Salvia miltiorrhiza extract Aminomethyl propanediol, A. propanol

Sambucus nigra extract Apricot kernel oil PEG-6 esters

Shark liver oil Benzalkonium chloride

Shorea robusota extract Butoxydiglycol

Sodium chondroitin sulfate Butyl glucoside Soluble transgenic elastin Butylene glycol

Steartrimonium hydroxyethyl hydrolyzed Butyloctanol collagen Capric-caprylic mono-diglyceride

Sterculia platanifolia extract Capryl caprylylglucoside

Superoxide dismutase Caprylic/capric triglyceride Trachea hydrolysate Caprylic/capric/linoleic triglyceride

Wheat (Triticum vulgare) germ extract, protein Caprylic/capric/oleic triglycerides

White nettle (Lamium album) extract Caprylyl/capryl glucoside

Withania somniferum extract Ceteareth-20 Ceteth-10 PEG-40 hydrogenated castor oil PCA isostearate

Cetyl PPG-2 isodeceth-7 carboxylate PEG-40 sorbitan diisostearate

Cholesterol PEG-45 palm kernel glycerides

Com oil PEG-6 esters PEG-48 hydrogenated castor oil Decaglycerol monodioleate PEG-50 castor oil

Diethanolamine PEG-50 hydrogenated castor oil

Dilaureth-10 phosphate PEG-60 almond glycerides

Dimethyl octynediol PEG-60 castor oil

Dioleth-8 phosphate PEG-60 com glycerides Glycereth-7 -26 PEG-60 glyceryl isostearate, P.g. stearate

Glyceryl caprylate, G. dilaurate PEG-60 hydrogenated castor oil

Glyceryl caprylate/caprate PEG-60 lanolin

Isoeicosane PEG-70 mango glycerides

Isopropanolamine PEG-75 lanolin Isosteareth-20 PEG-75 shea butter glycerides

Laneth-5, -15 PEG-75 shorea butter glycerides

Laureth-23 PEG-80 hydrogenated castor oil

Methylated cyclodextrin PEG-80 jojoba acid/alcohol

Myreth-3 PEG-80 sorbitan laurate Myreth-3-octanoate PEG-100 castor oil

Nonoxynol-10, -12, -14, -40, -50 PEG- 100 hydrogenated castor oil

Octoxynol-11, -40 PEG-120 jojoba acid/alcohol

Oleoamphohydroxypropylsulfonate PEG-200 trihydroxystearin

Oleth-3, -5, -10, -15, -20, -25, -50 Poloxamer 407 Oleth-20 phosphate Polyglyceryl-3 oleate

PEG-4, -6, -8, -12, -16, -20, -32, -40 Polyglyceryl-6 dioleate

PEG-4 dilaurate Polyglycery-10 decaoleate, P. tetraoleate

PEG-6 capric/caprylic glycerides Polysorbate 20, 60, 80

PEG-6 methyl ether PPG-2-isodeceth-4, -6, -9, -12 PEG-8 distearate PPG-3 isosteareth-9

PEG-12 laurate PPG-3 isoceteth-20 acetate

PEG-15 castor oil PPG-5-ceteth-10 phosphate

PEG- 18 stearate PPG-5-ceteth-20

PEG-20 glyceryl isostearate, P.g. laurate PPG-6-decyltetradeceth-12, -20, -30 PEG-20 glyceryl oleate, P.g. stearate PPG-12-PEG-65 lanolin oil

PEG-20 methyl glucose sesquistearate PPG- 15 stearyl ether

PEG-20 sorbitan isostearate PPG- 18 butyl ether

PEG-20 sorbitan triisostearate PPG-24 butyl ether

PEG-24 hydrogenated lanolin PPG-26-buteth-26 PEG-25 castor oil PPG-33 butyl ether

PEG-25 hydrogenated castor oil PPG-33-buteth-45

PEG-30 castor oil PPG-40-PEG-60 lanolin oil

PEG-30 glyceryl cocoate PPG-50 cetyl ether

PEG-30 glyceryl isostearate Propylene glycol dicaprylate, PEG-30 glyceryl laurate dicaprylate/dicaprate

PEG-30 glyceryl oleate Ricinoleamide DEA

PEG-30 glyceryl stearate Ricinoleth-40

PEG-33 castor oil Sodium alpha olefin sulfonate

PEG-35 castor oil Sodium lauryl sulfate PEG-36 castor oil Sodium methylnaphthalenesulfonate

PEG-40 castor oil Triethanolamine

PEG-40 glyceryl laurate, P.g. stearate Trioctanoin

PEG-40 hydrogenated castor oil Tromethamine Solvent Morpholine

Acetic acid Octyl benzoate, O. isononanoate

Acetone Octyl laurate, O. palmitate

Alcohol, A. denat Octyldodecyl lactate Benzophenone Olive oil PEG-6 esters

Butoxydiglycol Peanut oil PEG-6 esters

Butyl acetate Pentane n-Butyl alcohol Petroleum distillates

Butyl myristate, B. stearate PEG-6 methyl ether Butylene glycol PEG-12

C9-11 isoparaffin PEG-20 hydrogenated castor oil

CIO- 11 isoparaffin PEG-33 castor oil

CIO- 13 isoparaffin PEG-50 glyceryl cocoate

Caprylic alcohol Polyglyceryl-2 dioleate Castor (Ricinus communis) oil Polyglyceryl-3 diisostearate

Cetearyl octanoate Polyoxyethylene glycol dibenzoate

Cetyl stearyl octanoate Polypropylene glycol dibenzoate

Chlorobutanol PPG-2 myristyl ether propionate

Decyl alcohol PPG-3 Diethylene glycol PPG-20 lanolin alcohol ether

Diethylene glycol dibenzoate Propyl alcohol

Diethyl sebacate Propylene carbonate

Diisocetyl adipate Propylene glycol

Diisopropyl adipate, D. sebacate Propylene glycol dibenzoate Dimethyl phthalate Propylene glycol methyl ether

Dipropylene glycol Propylene glycol myristate

Dipropylene glycol dibenzoate Pyridine

Ethoxydiglycol Sesame (Sesamum indicum) oil

Ethyl acetate, E. lactate Stearyl heptanoate Ethyl myristate, E. oleate Toluene

2-Ethylhexyl isostearate Xylene

Glycerin

Glycofurol SPF booster

Heptane Borojoa sorbilis extract Hexyl alcohol Isohexadecyl salicylate

Hexylene glycol Styrene/acrylates copolymer

Isobutyl stearate Titanium dioxide

Isocetyl salicylate Yeast (Saccheromyces cerevisiae) extract (Faex)

Isodecyl benzoate, I. isononanoate Isodecyl octanoate, I. oleate Stabilizer

Isododecane Acrylates-VA crosspolymer

Isoeicosane Acrylates/ceteth-20 methacrylates copolymer

Isohexadecane Acrylates/steareth-20 methacrylate copolymer

Isopropyl alcohol, I. myristate Acrylates/vinyl isodecanoate crosspolymer Isostearyl stearoyl stearate Alkyldimethylamine oxide

Laureth-2 acetate C 10 polycarbamyl polyglycol ester

Methoxydiglycol Calcium alginate

Methoxyisopropanol Cocamidopropyl dimethylamine lactate

Methyl alcohol Cocamine oxide Methyl propanediol Colloidal silica sols

Methylene chloride Cyclodextrin

MEK Disodium EDTA

MIBK Gellan gum Glyceryl diisostearate, G. stearate SE 3-Benzylidene camphor

Glyceryl mono-di-tri-caprylate Borojoa sorbilis extract

Hydrogenated coco-glycerides C12-15 alkyl benzoate

Hydrogenated C12-18 triglycerides Coffee (Coffea arabica) bean extract Hydrogenated tallow glycerides Ethyl salicylate

Hydrolyzed oat flour Glyceryl PABA

Hydroxyoctacosanyl hydroxystearate Homosalate

Karaya (Stericulia urens) gum Hydroquinone-beta-D-glucopyranoside

Laureth-3 Isoamyl p-methoxycinnamate Maltitol Isopropylbenzyl salicylate

Methylated cyclodextrin Job's tears (Coix lacryma-jobi) extract

Oleamide Menthyl anthranilate

PEG-40 stearate Octyl dimethyl PABA, O. methoxycinnamate

PEG-40/dodecyl glycol copolymer Octyl salicylate, O. triazone Perfluoropolymethylisopropyl ether Oryzanol

Polyethylene paste Pansy (Viola tricolor) extract

PPG-5 lanolin wax PEG-25 PABA

PPG-7-buteth-10 Phenylbenzimidazole sulfonic acid

PPG-10 cetyl ether phosphate Rice (Oryza sativa) bran oil Propylene carbonate, P. glycol alginate TEA-salicylate

PVM/MA decadiene crosspolymer Titanium dioxide

Sodium acrylates/vinyl isodecanoate crosspolymer Sunscreen UVB

Sodium carbomer Benzophenone-5 Sorbitan laurate Eclipta alba extract

Stearic hydrazide PEG-25 PABA

2 , 2 ' ,4 ,4 ' -Tetrahydroxybenzophenone Steareth-100

Tricaprin Tridecyl salicylate

Tricaprylin Trilaurin Superfatting agent

Trimyristin Linoleamide DEA

Tripalmitin PEG-20 almond glycerides

Tristearin PEG-60 lanolin PEG-75 lanolin Stimulant

Capsicum fratescens extract Surfactant

Eleuthero ginseng (Acanthopanax senticosus) Alkyl dimethyl betaine extract Alkyldimethylamine oxide

Guarana (Paullinia cupana) extract Ammonium cocoyl sarcosinate Lactococcus hydrolysate Ammonium C12-15 alkyl sulfate

Methylsilanol elastinate Ammonium dimethicone copolyol sulfate

Methylsilanol hydroxyproline aspartate Ammonium laureth-5 sulfate

TEA-hydroiodide Ammonium laureth- 12 sulfate

Tocopheryl nicotinate Ammonium laureth sulfate Urocanic acid Ammonium lauroyl sarcosinate

Yeast (Saccheromyces cerevisiae) extratc (Faex) Ammonium lauryl sulfate, A.l. sulfosuccinate

Zedoary (Curcyma zedoraria) oil Ammonium myreth sulfate

Zinc DNA Ammonium nonoxynol 4 sulfate

Azelamide MEA Sunscreen C20-40 alcohol ethoxylate

Basil (Basilicum santum) oil extract C30-50 alcohol ethoxylate Basil (Ocimum basilicum) extract C40-60 alcohol ethoxylate Benzophenone-3 -4 Calcium dodecylbenzene sulfonate Calcium laurate Disodium oleth-3 sulfosuccinate

Ceteareth-2 phosphate Disodium ricinoleamido MEA-sulfosuccinate

Ceteareth-5 phosphate Disodium tallamido MEA-sulfosuccinate

Ceteareth-10 phosphate Disteareth-2 lauroyl glutamate Cetoleth-25 Disteareth-5 lauroyl glutamate

Cetyl betaine, C. phosphate Ethoxylated fatty alcohol

Cocamide MEA ethoxylate Ethoxylated glycerol sorbitan samrated fatty acid

Cocamidopropyl betaine, potassium salt ester

Cocamidopropyl betaine ammonium salt Ethoxylated glycerol sorbitan unsamrated fatty Cocamidopropyl hydroxy sultaine acid ester

Cocamidopropyl hydroxy sultaine, ammonium Glycereth-25 PCA isostearate salt Glycereth-26 phosphate

Cocamidopropyl hydroxy sultaine, potassium salt glyceryl hydroxystearate

Cocamidopropylamine oxide Hydrogenated tallowoyl glutamic acid Coceth-7 carboxylic acid Isopropyl hydroxybutyramide dimethicone

Coco-glucoside coppolyol

Cocoamphodiacetate lauryl-laureth sulfate Lauramidopropyl betain

Cocoamphodiacetate lauryl sulfate Laureth-1, -2, -3, -4, -7, -12, -16

Cocoamphodiacetate trideceth sulfate Laureth-3 carboxylic acid, L. phosphate Coco phosphatidyl PG-dimonium chloride Laureth-5 carboxylic acid

N-Cocoyl-(3-amidoproρyl)-N,N-dimethyl-N-ethyl Laureth- 11 carboxylic acid ammonium ethyl sulfate Lauroyl sarcosine

Cocoyl glutamic acid Lauryl dimethylamine cyclocarboxypropyloleate

Cocoyl hydrolyzed soy protein Laryl hydroxyethyl imidazoline Cocoyl hydroxyethyl imidazoline Linoleamide DEA

Cl l-15 pareth-9, -12, -20, -30, -40 Magnesium laureth-8 sulfate

C12-13 pareth sulfate Meroxapol 105, 171, 172

C12-13 pareth-5 carboxylic acid MEA-lauryl sulfate

C12-15 pareth-12 Mixed isopropanolamines myristate C 14-15 pareth-8 carboxylic acid Myreth-7

DEA-oleth-5-phosphate Myristoyl sarcosine

DEA-oleth-20-phosphate Myristyl alcohol

Deceth-3, -6, -8 Nonoxynol-7, -9, -13, -15

Decyltetradeceth-25 Nonoxynol-10 carboxylic acid Diceteareth-10 phosphoric acid Octoxynol-10, -12

Dimethicone copolyol Octyldodeceth-10, -16

Dimethicone copolyol almondate, D.c. Oleoyl sarcosine isostearate Oleth-2 phosphate

Dimethicone copolyol laurate, D.c. olivate Oleth-5 phosphate Dimethicone copolyol phthalate Oleyl betaine

Dimethicone copolyolamine Oleyl hydroxyethyl imidazoline

Dimethicone propyl PG-betaine Palmitamine oxide

Dioctyldodeceth-2 lauroyl glutamate Palmityl betaine

Dioctyldodeceth-5 lauroyl glutamate PCA ethyl cocoyl arginate Dioctyldodecyl lauroyl glutamate PEG-7 hydrogenated castor oil

Disodium capryloamphodiacetate PEG-8 caprylic/capric glycerides

Disodium cocoamphodiacetate PEG-8 laurate

Disodium hydrogenated tallow glutamate PEG-8 stearate

Disodium laneth-5 sulfosuccinate PEG-15 glyceryl stearate Disodium lauramido MEA-sulfosuccinate PEG-25 glyceryl isostearate

Disodium laureth sulfosuccinate PEG-27 lanolin

Disodium oleamido MIPA-sulfosuccinate PEG-30 lanolin

Disodium oleamido PEG-2 sulfosuccinate PEG-40 castor oil PEG-40 glyceryl stearate Sodium laureth- 11 carboxylate

PEG-40 jojoba oil, P. lanolin Sodium laureth- 13-carboxylate

PEG-60 glyceryl isostearate, P.g. stearate Sodium laureth sulfate

PEG-80 jojoba oil, P. sorbitan laurate Sodium lauroamphoacetate PEG- 120 jojoba oil Sodium laruoyl glutamate

Pentasodium triphosphate Sodium lauroyl hydrolyzed collagen

Poloxamer 101 , 122 Sodium lauroyl sarcosinate, S.l. taurate

Polyglyceryl-2 dioleate Sodium magnesium laureth sulfate

Polysiloxane-polyether copolyer Sodium methyl cocoyl taurate Potassium cocoyl glycinate Sodium methyl oleoyl taurate

Potassium cocoyl hydrolyzed collagen Sodium myristoyl glutamate

Potassium C9-15 phosphate ester Sodium myristoyl hydrolyzed collagen

Potassium lauroyl hydrolyzed collagen Sodium myristoyl sarcosinate

Potassium lauryl sulfate Sodium myristyl sulfate Potassium myristoyl hydrolyzed collagen Sodium nonoxynol-6 phosphate

Potassium oleoyl hydrolyzed collagen Sodium octoxynol-2 ethane sulfonate

Potassium palmitate Sodium octyl sulfate

Potassium undecylenoyl hydrolyzed collagen Sodium oleoyl hydrolyzed collagen

PPG-2-isodeceth-4, -6, -9, -12 Sodium stearoyl hydrolyzed collagen PPG-6 C12-18 pareth-l l Sodium trideceth sulfate

Protein hydroylsates Sodium undecylenoyl hydrolyzed collagen

Quaternium-80 Sodium/TEA-lauroyl hydrolyzed collagen

Quillaja saponaria extract Sodium/TEA-lauroyl hydrolyzed keratin

Raffinose laurate, R. myristate, R. oleate Sorbitan isostearate Raffinose palmitate, R. stearate Stearoyl sarcosine

Ricinoleamidopropyl betain Sulfated castor oil

Silicone quaternium-1, -8, -9 TEA-cocoyl glutamate

Sodium alpha olefin sulfonate TEA-cocoyl hydrolyzed collagen

Sodium cocoamphoacetate TEA-cocoyl hydrolyzed soy protein Sodium cocoyl hydrolyzed wheat protein TEA-C12-15 alkyl sulfate

Sodium cocoyl isethionate TEA-hydrogenated tallow glutamate

Sodium C12-13 sulfate TEA-lauroyl glutamate

Sodium C12-14 pareth-2 sulfate TEA-lauroyl keratin amino acids

Sodium C12-15 pareth-3 sulfonate TEA-lauroyl sarcosinate Sodium C12-15 pareth-7 carboxylate TEA-lauryl sulfate

Sodium C12-15 pareth-7 sulfonate TEA-myristoyl hydrolyzed collagen

Sodium C12-15 pareth-8 carboxylate Tocophereth-5 -10 -18 -20 -30 -50 -70

Sodium C12-15 pareth-15 sulfonate Trideceth-7 carboxylic acid

Sodium C12-18 alkyl sulfate Trideceth-9 Sodium C13-17 alkane sulfonate Trideceth- 19-carboxy lie acid

Sodium C14-16 olefin sulfonate Tridecyl ethoxylate

Sodium cetearyl sulfate Triethanolamine CIO- 14 sulfate

Sodium cetyl oleyl sulfate Trilauryl phosphate

Sodium coco-tallow sulfate Wheat germamidopropyl betaine Sodium cocoyl glutamate Yucca vera extract

Sodium cocoyl hydrolyzed collagen

Sodium cocoyl hydrolyzed soy protein Suspending agent

Sodium cocoyl sarcosinate Acrylates/ceteth-20 methacrylates coppolymer

Sodium dimethicone copolyol acetyl Acrylates/steareth-20 methacrylate copolymer methyltaurate Algin

Sodium hydrogenated tallow glutamate Bentonite

Sodium isodecyl sulfate C 10 polycarbamyl polyglycol ester

Sodium laureth-5 carboxylate Calcium alginate Carbomer, C. 934 /C10-C30 alkyl acrylate crosspolymer

Carrageenan (Chondras crispus) /ceteth-20 itaconate copolymer

Cellulose gum /ceteth-20 methacrylates copolymer

Cetyl hydroxyethylcellulose /steareth-20 itaconate copolymer

Dihydrogenated tallow phthalic acid amide /steareth-20 methacrylate copolymer

Distearyl phthalic acid amide /steareth-50 acrylate copolymer

Guar (Cyanopsis tetragonoloba) gum /vinyl isodecanoate crosspolymer

Hectorite acid/acrylonitrogens copolymer

Hydroxypropylcellulose

Isobutylene/MA copolymer /magnesium hydroxide stearate

Magnesium aluminum silicate acrylates/acrylonitrogens copolymer

Methylcellulose _ alginate

Pentasodium triphosphate alcohol

Polyethylene, P. micronized _ acid

Propylene glycol alginate _ alcohol, B. behenate

Quaternium-18 bentonite __nite

Quaternium-18 hectorite olycarbamyl polyglycol ester

Sodium magnesium silicate 5 alcohols

Sodium polynaphthalenesulfonate 6 alcohols

Stearalkonium bentonite, S. hectorite 6 acid

Steareth-10 allyl ether/acrylates copolymer Calcium alginate (Astragalus gummifer) gum Calcium carrageenan ribehenin Caprylic alcohol rihydroxystearin Carbomer omethamine magnesium aluminum silicate Carboxymethyl hydroxyethylcellulose anthan gum Carrageenan (Chondras crispus)

Cellulose, C. gum

Sweetener Cetearyl alcohol, C. behenate saccharin Cetearyl octanoate, C. stearate

Cetostearyl stearate acid Cetyl alcohol acid Cetyl hydroxyethylcellulose

, ammoniated Cetyl myristate, C. palmitate com starch Cocamide

Cocamide MEA, C. MIPA

Cocamidopropylamine oxide

Coco-betaine

Coco-rapeseedate saccharin Coco/oleamidopropyl betaine

Cocoyl amido hydroxy sulfo betaine

Cocoyl monoethanolamide ethoxylate

Colloidal silica sols accelerator DEA-hydrolyzed lecithin tyrosine DEA-linoleate

Carrot (Daucus carota) extract DEA-oleth-3 phosphate acetyl tyrosinate methylsilanol DEA oleth-10 phosphate droxyacetone Decyl alcohol malyl tyrosinate Dextran alba extract in white emulsion Dextrin tyrosinate Dilaureth-10 phosphate

Dioleth-8 phosphate ckener DMHF

-VA crosspolmer Ethoxylated fatty alcohol Gellan gum

Glyceryl behenate, G. stearate

Glyceryl polymethacrylate

Guar (Cyanopsis tetragonoloba) gum

Guar hydroxypropyltrimonium chloride

Hectorite

Hexyl alcohol

Hydrated silica

Hydrogenated rapeseed oil

Hydrogenated starch hydrolysate

Hydrogenated talloweth-60 myristyl glycol

Hydrolyzed oat flour

Hydrolyzed transgenic collagen

Hydroxyethylcellulose

Hydroxypropyl chitosan PEG-6 beeswax

Hydroxypropyl guar PEG-7 hydrogenated castor oil

Hydroxypropyl methylcellulose PEG-8

Hydroxypropylcellulose PEG-8 dioleate, P. distearate

Isoceteth-10 PEG-8 stearate

Isostearamide DEA PEG-9M

Isostearamidopropylamine oxide PEG-12 beeswax

Isostearoamphopropionate PEG- 18 glyceryl oleate/cocoate

Jojoba wax PEG-23M

Karaya (Stericulia urens) gum PEG-28 glyceryl tailowate

L DEA, L. MEA, L. MIPA PEG-40 jojoba oil

L midopropyl betaine PEG-45M

Laureth- 10 PEG-50 tallow amide

L -linoleic DEA PEG-55 propylene glycol oleate

L -linoleoyl diethanolamide PEG-75 stearate

L -myristoyl diethanolamide PEG-90M

L alcohol, L. betaine PEG- 100 stearate

L amide DEA, L. MEA PEG- 120 methyl glucose dioleate

L eic acid PEG-150 distearate

L mic acid PEG-150 pentaerythrityl tetrastearate

L bean (Ceratonia siliqua) gum PEG-160M

Magnesium aluminum silicate PEG-200 glyceryl stearate

MDM hydantoin PEG-200 glyceryl tailowate

Methylcellulose Pentaerythrityl tetrabehenate

Montmorillonite Pentaerythrityl tetrastearate

Myristamide DEA, M. MEA Poloxamer 105, 124, 185, 237, 238, 338, 407

Myristamine oxide Polyacrylic acid

Myristyl alcohol Polysorbate 20

Octacosanyl stearate Potassium alginate, P. chloride

Oleamide, O. DEA, O. MEA Potassium oleate, P. stearate

Palmitamide MEA PPG-5-ceteth-10 phosphate

Pectin Propylene glycol stearate

PEG-2 laurate PVM/MA decadiene crosspolymer

PEG-3 distearate, P. lauramide PVP

PEG-3 lauramine oxide Quaternium-18 bentonite

PEG-4 diisostearate, P. oleamide Quaternium-18 hectorite

PEG-5M Rapeseed oil, ethoxylated high eracic acid Ricinoleamide MEA Isopropyl dibenzoylmethane

Sesamide DEA Menthyl anthranilate

Sodium acrylates/vinyl isodecanoate crosspolymer 2 , 2 ' , 4 , 4 ' -Tetrahy droxy benzophenone

Sodium carbomer, S. carrageenan Titanium dioxide Sodium ceteth-13-carboxylate Zinc oxide

Sodium chloride

Sodium magnesium silicate, S. stearate UVB abosrber

Sorbitan sesquiisostearate, S. tristearate Argania spinosa oil

Soyamide DEA Benzophenone-1 -2 -3 -4 -6 -9 -11 Soyamidopropyl betaine Corallina officinalis

Starch polyacrylonitrile copolymer-potassium salt DEA-methoxycinnamate

Starch polyacrylonitrile copolymer-sodium salt Drometrizole

Stearalkonium bentonite, S. hectorite Ethyl dihydroxypropyl PABA

Stearamide Etocrylene Stearamide DEA, S. MEA, S. MEA-stearate homosalate

Stearamidopropyl dimethylamine lactate Isoamyl p-methoxycinnamate

Stearamine oxide Isopropyl methoxycinnamate

Steareth-10 allyl ether/acrylates copolymer Isopropylbenzyl salicylate

Stearic acid 4-Methylbenzylidene camphor Stearyl alcohol Octocrylene

Synthetic beeswax Octrizole

Tallowamide MEA Octyl dimethyl PABA

TEA-acrylates/acrylonitrogens copolymer Octyl methoxycinnamate

Tragacanth (Astragalus gummifer) gum Octyl salicylate, O. triazne Tribehenin PABA

Trihydroxystearin PEG-25 PABA

Tromethamine magnesium aluminum silicate Phenylbenzimidazole sulfonic acid

Wheat germamide DEA Shea butter, ethoxylated

Wheat germamidopropyl betain TEA-salicylate Xanthan gum Titanium dioxide

TriP ABA panthenol

Thixotrope Zinc oxide

Bentonite Hectorite Vegetable oil Sodium magnesium silicate Apricot (Pranus armeniaca) kernel oil Stearalkonium bentonite Avocado (Persea gratissima) oil

Baobab oil

Toner Calendula officinalis oil

Althea officinalis extract Chaulmoogra (Taraktogenos kurzii) oil Clover (Trifolium pratense) extract Coconut (Cocos nucifera) oil

Dog rose (Rosa canina) hips extract Com (Zea mays) oil

Ginseng (Panax ginseng) extract Cottonseed (Gossyplum) oil

Horsetail extract Gold of pleasure oil

Lemon bioflauonoids extract Grape (Vitis vinifera) seed oil Meadowsweet (Spiraea ulmaria) extract Hazel (Corylus avellana) nut oil

Nettle (Uritca dioica) extract Hybrid sunflower (Helianthus annuus) oil

Rose (Rosa multiflora) extract Hydrogenated coconut oil

Rosemary (Rosmarinus officinalis) extract Hydrogenated cottonseed oil

Hydrogenated vegetable oil UVA absorber Jojoba (Buxus chinensis) oil

Benzophenone-1, -2, -3, -4, -6, -8, -9, -11, -12 Kukui (Aleurites molaccana) nut oil Butyl methoxydibenzoylmethane Macadamia temifolia nut oil Corallina officinalis Meadowfoam (Limnanthes alba) seed oil Mexican poppy oil Retinyl palmitate polypeptide

Palm (Elaeis guineensis) kernel oil Retinyl propionate

Partially hydrogenated soybean oil Riboflavin tetraacetate

Peach (Prunus persica) kernel oil Sodium ascorbate Peanut (Arachis hypogaea) oil Thiamine HCL

Pecan (Carya illinoensis) oil Tocopherol

Pumpkin (Cucurbita pepo) seed oil Tocopheryl acetate, T. succinate

Quinoa (Chenopodium quinoa) oil

Rapeseed (Brassica capestris) oil Wax Rice (Oryza sativa) bran oil Bayberry (Myrica cerifera) wax

Safflower (Carthamus tinctorius) oil Behenoxy dimethicone

Seabuckthorn oil C16-18 alkyl methicone

Sesame (Sesamum indicum) oil Candelilla (Euphorbia cerifera) wax

Sisymbrium irio oil Carnauba (Copemicia cerifera) wax Soybean (Glycine soja) oil Ceresin

Sunflower (Helianthus annuus) seed oil Cetyl dimethicone, C. isooctanoate

Walnut (Juglans regia) oil Dialkyldimetiiylpolysiloxane

Wheat (Triticum vulgare) germ oil Dimethiconol hydroxystearate

Wild borage oil Dimethiconol stearate

Hydrogenated castor oil

Vitamin Hydrogenated cottonseed oil

Aesculus chinensis extract Hydrogenated jojoba oil, H.j. wax

Ascorbic acid Hydrogenated palm kernel oil

Ascorbic acid polypeptide Hydrogenated rapeseed oil Ascorbyl palmitate Hydrogenated rice bran wax

Biotin hydrogenated vegetable oil

Calcium pantothenate Isooctadecyl isononanoate

Cholecalciferol Japan (Rhus succedanea) wax

Cyanocobalamin Jojoba esters Eclipta alba extract Montan (Montan cera) wax

Emblica officinalis extract Ouricury wax

Equisetum arvense extract Ozokerite

Ergocalciferol Polyglyceryl-3 beeswax

Esculin Spermaceti Ethyl linoleate Stearoxymethicone/dimethicone copolymer

Folic acid Stearoxytrimethylsilane

Laminaria japonica extract Synthetic candelilla wax

Marsilea minuta extract Synthetic carnauba

Melaleuca bracteata extract Menadione Wetting agent

Nasturtium sinensis extract Benzalkonium chloride

Nelumbium speciosum extract Benzethonium chloride

Niacin Cetalkonium chloride

Niacinamide, N. ascorbate Ceteareth-20 Nicotinamide Ceteth-20

Nicotinic acid Cetyl pyridinium chloride

Ocimum basilicum extract Cocoamphodipropionic acid

Panthenyl triacetate Decaglycerol monodioleate

Pantothenic acid Deceth-9 Phytonadione Dihydroabietyl methacrylate

Pyridoxine HC1 Dimethicone copolyol methyl ether

Retinol Dimethicone copolyol phthalate

Retinyl acetate, R. palmitate Dioctyl sodium sulfosuccinate Ethyl hydroxymethyl oleyl oxazoline

Hydroxylated milk glycerides

Isolaύreth-6

Lanolin acid Lauryl pyrrolidone

Lecithin

Methyl hydrogenated rosinate

Methyl rosinate

Nonyl nonoxynol-5 Octoxynol-8, 70

Oleth-15

Oleth-20 phosphate

PEG-9 castor oil

PEG-15 castor oil PEG-20 glyceryl stearate

PEG-20 sorbitan triisostearate

PEG-45 palm kernel glycerides

PEG-60 almond glycerides, P. com glycerides

PEG-60 shea butter glycerides PEG-70 mango glycerides

PEG-75 shorea butter glycerides

PEG-80 sorbitan laurate

Poloxamer 123, 181, 182, 184, 235, 334

Polyether trisiloxane Polyglyceryl-3 oleate

Polyglyceryl-6 dioleate

Polyglyceryl-10 tetraoleate

Polysorbate 60, 80

PPG-2-isodeceth-4, -6, -9, -12 PPG-10 lanolin alcohol ether

Propylene glycol

Sodium butoxyethoxy acetate

Sodium capryloamphohydroxypropylsulfonate

Sodium decyl diphenyl ether sulfonate Sodium dodecyldiphenyl ether sulfonate

Sodium lauryl sulfate

Sulfated castor oil

Triisocetyl citrate

Triisostearin PEG-6 esters Yucca vera extract

Claims

Claims:

^' M . A cosmetic composition comprising: a cosmetically acceptable carrier, comprising a reverse thermal viscosifying polymer network comprising at least one poloxamer component randomly bonded to at least one poly(acrylic acid) component said polymer network capable of aggregation in response to a change in temperature; and a cosmetically active agent which imparts a preselected cosmetic effect, said carrier and said agent disposed within an aqueous-based medium.

2. A cosmetic composition for topical application, comprising: a cosmetically acceptable carrier, comprising a reverse thermal viscosifying polymer network comprising at least one poloxamer component capable of aggregation in response to a change in temperature randomly bonded to at least one poly(acrylic acid) component; and a cosmetically active agent selected to treat imperfections or disorders of the skin, said carrier and said agent disposed within an aqueous-based medium.

3. The cosmetic composition of claim 1, wherein the cosmetic composition is a shampoo and the cosmetically active agent comprises a cleansing surfactant.

4. The cosmetic composition of claim 1, wherein the cosmetic composition is a moisturizer and the cosmetically active agent comprises a moisturizer.

5. The cosmetic composition of claim 1, wherein the cosmetic composition is a sunscreen and the cosmetically active agent comprises a UV-absorbing agent.

6. The cosmetic composition of claim 1, wherein the cosmetic composition is an acne cream and the cosmetically active agent comprises an antiacne agent.

7. The cosmetic composition of claim 1 , wherein the cosmetic composition is a ir straightener and the cosmetic agent comprises a base for increasing the pH.

8. The cosmetic composition of claim 1, wherein the cosmetic composition is a sunless tanning lotion and the cosmetically active agent comprises skin tinting agent.

9. The cosmetic composition of claim 1, wherein the cosmetic composition is an antiperspirant and the cosmetically active agent comprises aluminum chlorhydrate.

10. The cosmetic composition of claim 1, wherein the cosmetic composition is a shaving cream and the cosmetically active agent comprises an emollient and a foaming surfactant.

11. The cosmetic composition of claim 1 , wherein the cosmetic composition is a face cosmetic and the cosmetically active agent comprises a pigment.

12. The cosmetic composition of claim 1 or 2, wherein the cosmetic agent comprises a hydrophobic material, wherein the cosmetically acceptable carrier stabilizes the hydrophobic material in the aqueous medium.

13. The cosmetic composition of claim 2, wherein said cosmetic agent selected to treat imperfections or disorders of the skin is selected from the group consisting of acidulents, antiacne agents, anti-aging agents, anti-inflammatories, anti- irritants, antioxidants, depilatories, detergents, disinfectants, emollients, exfoliants, humectants, lubricants, moisturizers, skin conditioners, skin protectants, skin lightening agents, skin soothing agents, sunscreening agents, and tanning accelerators and mixtures thereof.

14. The composition of claim 4, wherein said composition further comprises a cosmetic agent selected from the group consisting of humectants and emollients.

15. The composition of claim 1 or 2, further comprising one or more additives selected from the group consisting of preservatives, abrasives, acidulents, antiacne agents, anti-agin agents, antibacterials, anticaking, anticaries agents, anticellulites, antidandruff, antifungal, anti-inflammatories, anti-irritants, antimicrobials, antioxidants, astringents, antiperspirants, antiseptics, antistatic agents, binders, buffers, additional carriers, chelators, cell stimulants, cleansing agents, conditioners, deodorants, depilatories, detergents, dispersants, emollients, emulsifiers, enzymes, essential oils, exfoliants, fibers, film forming agents, fixatives, foaming agents, foam stabilizers, foam boosters, fungicides, gellants, glosser, hair conditioner, hair set resins, hair sheen agents, hair waving agents, humectants, lubricants, moisture barrier agents, moisturizers, ointment bases, opacifier, plasticizer, polish, polymers, powders, propellant, protein, refatting agents, sequestrant, silicones, skin calming agents, skin cleansers, skin conditioners, skin healing, skin lightening agents, skin protectants, skin smoothing agents, skin softening agents, skin soothing agents, stabilizers, sunscreen agents, surfactants, suspending agents, tanning accelerators, thickeners, vitamins, waxes, wetting agents, liquefiers, colors, flavors and/or fragrances.

16. The composition of claim 1, wherein the cosmetic composition takes a form selected from the group consisting of lotions, creams, sticks, roll-on formulations, mousses, sprays, aerosols, pad-applied formulations and masks.

17. The composition of claim 1, wherein the viscosification occurs at a temperature in the range of about 27-40 ┬░C.

18. The composition of claim 1, wherein the viscosification occurs at a temperature in the range of about 30 to 37┬░C.

19. The composition of claim 1, wherein said composition is formulated as a product selected form the group consisting of baby products, baby shampoos, lotions, powders and creams; bath preparations, bath oils, tablets and salts, bubble baths, bath fragrances, bath capsules; eye makeup preparations, eyebrow pencil, eyeliner, eye shadow, eye lotion, eye makeup remover, mascara; fragrance preparations, colognes, toilet waters, powders and sachets; noncoloring hair preparations, hair conditioner, hair spray, hair straighteners, permanent waves, rinses, shampoos, tonics, dressings and other grooming aids; color cosmetics; hair coloring preparations, hair dye, hair tints, hair color sprays, hair lighteners and hair bleaches; makeup preparations, face powders, foundations, leg and body paints, lipstick; makeup bases, rouges and makeup fixatives; manicuring preparations, basecoats, undercoats, cuticle softeners, nail creams, nail extenders, mail polish and enamel, and remover, oral hygiene products, dentrifices, mouthwashes; personal cleanliness, bath soaps, detergents, deodorants, douches and feminine hygiene products; shaving preparations, aftershave lotion, beard softeners, men's talcum shaving cream, shaving soap, preshave lotions; skin care preparations, skin cleansing preparations, skin antiseptics, depilatories, face and neck cleansers, body and hand cleansers, foot powders; moisturizers, night preparations, paste masks, skin fresheners; and suntan preparations, suntan creams, gels and lotions, and indoor tanning preparations.

20. The cosmetic composition of claim 1 or 2, wherein the poloxamer component is present in an amount in the range of about 0.01 to 20 wt and the poly (acrylic acid) component is present in the amount of about 0.01 to 20 wt%.

21. The cosmetic composition of claim 1 , wherein the polymer network comprises a plurality of poloxamers.

22. The cosmetic composition of claim 1, wherein the polymer network comprises a plurality of poloxamer components randomly bonded to a poly(acrylic acid) backbone.

23. The cosmetic composition of claim 1 , wherein the reversibly viscosifying polymer composition comprises a plurality of poly(acrylic acid) components randomly bonded to a poloxamer component.

24. The cosmetic composition of claim 1, wherein the aqueous-based medium is selected from the group consisting of water, salt solutions and water with water-miscible organic compound(s).

25. The cosmetic compositions of claim 1, further comprising an additive selected to increase transition temperature and increase viscosity of the reversible viscosifying polymer network.

26. The cosmetic composition of claim 1, further comprising an additive selected to increase transition temperamre and decrease viscosity of the reversible viscosifying polymer network.

27. The cosmetic composition of claim 1, further comprising an additive selected to increase transition temperamre without affecting viscosity of the reversible viscosifying polymer network.

28. The cosmetic composition of claim 1, further comprising an additive selected to decrease transition temperamre and increase viscosity of the reversible viscosifying polymer network.

29. The cosmetic composition of claim 1, further comprising an additive selected to decrease transition temperamre and decrease viscosity of the reversible viscosifying polymer network.

30. The cosmetic composition of claim 1, further comprising an additive selected to decrease transition temperamre without affecting viscosity of the reversible viscosifying polymer network.

31. The cosmetic composition of claim 1, further comprising an additive selected to increase viscosity without affecting transition temperamre of the reversibly viscosifying polymer network.

32. The cosmetic composition of claim 1, further comprising an additive selected to decrease viscosity without affecting transition temperamre of the reversibly viscosifying polymer network.

33. The cosmetic composition of claim 1 or 2, characterized in that the gel remains translucent to light before and after response to the environmental stimulus.

34. The cosmetic composition of claim 1, wherein the poly (acrylic acid) is branched.

35. Method of making a cosmetic composition, comprising: dissolving a poloxamer capable of aggregation in response to a change in temperamre in acrylic acid monomer; initiating polymerization of the monomer to form a poly(acrylic acid) randomly bonded to the poloxamer, so as to form a reversibly viscosifying polymer composition; mixing the reversibly gelling polymer compositions with a cosmetic agent which imparts a desired cosmetic effect to the composition.

36. The method of claim 36, wherein a polymerization initiator is selected to provide the polymer network having a selected temperamre of viscosification.

37. The method of claim 36, wherein one or more poloxamers are added.

38. The cosmetic composition of claim 1, wherein the reversibly viscosifying polymer network is present in an amount in the range of 0.01 % - 10% .