WO1998045712A3 - 20 human secreted proteins - Google Patents

20 human secreted proteins Download PDF

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Publication number
WO1998045712A3
WO1998045712A3 PCT/US1998/006801 US9806801W WO9845712A3 WO 1998045712 A3 WO1998045712 A3 WO 1998045712A3 US 9806801 W US9806801 W US 9806801W WO 9845712 A3 WO9845712 A3 WO 9845712A3
Authority
WO
WIPO (PCT)
Prior art keywords
secreted proteins
human secreted
proteins
relates
diagnosing
Prior art date
Application number
PCT/US1998/006801
Other languages
French (fr)
Other versions
WO1998045712A2 (en
Inventor
Craig A Rosen
Steven M Ruben
Guo-Liang Yu
Jian Ni
Ping Feng
Original Assignee
Human Genome Sciences Inc
Craig A Rosen
Steven M Ruben
Yu Guo Liang
Jian Ni
Ping Feng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP98915313A priority Critical patent/EP0974058A2/en
Priority to CA002286303A priority patent/CA2286303A1/en
Priority to AU69529/98A priority patent/AU6952998A/en
Priority to JP54300598A priority patent/JP2001521383A/en
Application filed by Human Genome Sciences Inc, Craig A Rosen, Steven M Ruben, Yu Guo Liang, Jian Ni, Ping Feng filed Critical Human Genome Sciences Inc
Publication of WO1998045712A2 publication Critical patent/WO1998045712A2/en
Publication of WO1998045712A3 publication Critical patent/WO1998045712A3/en
Priority to US09/814,122 priority patent/US20020058307A1/en
Priority to US10/100,683 priority patent/US7368531B2/en
Priority to US10/649,857 priority patent/US20040063128A1/en
Priority to US10/664,357 priority patent/US20070055056A1/en
Priority to US10/664,356 priority patent/US20070015696A1/en
Priority to US11/001,793 priority patent/US7411051B2/en
Priority to US11/346,470 priority patent/US20060223088A1/en
Priority to US11/366,980 priority patent/US20060223090A1/en
Priority to US11/366,486 priority patent/US20060246483A1/en
Priority to US11/687,755 priority patent/US20080103090A1/en
Priority to US11/689,173 priority patent/US20070224663A1/en
Priority to US12/198,817 priority patent/US7968689B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Abstract

The present invention relates to 20 human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these human secreted proteins.
PCT/US1998/006801 1997-03-07 1998-04-07 20 human secreted proteins WO1998045712A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
EP98915313A EP0974058A2 (en) 1997-04-08 1998-04-07 20 human secreted proteins
CA002286303A CA2286303A1 (en) 1997-04-08 1998-04-07 20 human secreted proteins
AU69529/98A AU6952998A (en) 1997-04-08 1998-04-07 20 human secreted proteins
JP54300598A JP2001521383A (en) 1997-04-08 1998-04-07 20 human secretory proteins
US09/814,122 US20020058307A1 (en) 1997-04-08 2001-03-22 20 Human secreted proteins
US10/100,683 US7368531B2 (en) 1997-03-07 2002-03-19 Human secreted proteins
US10/649,857 US20040063128A1 (en) 1997-04-08 2003-08-28 20 Human secreted proteins
US10/664,357 US20070055056A1 (en) 1997-03-07 2003-09-20 251 human secreted proteins
US10/664,356 US20070015696A1 (en) 1997-03-07 2003-09-20 621 human secreted proteins
US11/001,793 US7411051B2 (en) 1997-03-07 2004-12-02 Antibodies to HDPPA04 polypeptide
US11/346,470 US20060223088A1 (en) 1997-03-07 2006-02-03 Human secreted proteins
US11/366,980 US20060223090A1 (en) 1997-03-07 2006-03-03 Polynucleotides encoding human secreted proteins
US11/366,486 US20060246483A1 (en) 1997-03-07 2006-03-03 337 human secreted proteins
US11/687,755 US20080103090A1 (en) 1997-03-07 2007-03-19 Human Secreted Proteins
US11/689,173 US20070224663A1 (en) 1997-03-07 2007-03-21 Human Secreted Proteins
US12/198,817 US7968689B2 (en) 1997-03-07 2008-08-26 Antibodies to HSDEK49 polypeptides

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US4272697P 1997-04-08 1997-04-08
US4272797P 1997-04-08 1997-04-08
US4272897P 1997-04-08 1997-04-08
US4275497P 1997-04-08 1997-04-08
US4282597P 1997-04-08 1997-04-08
US60/042,726 1997-04-08
US60/042,754 1997-04-08
US60/042,727 1997-04-08
US60/042,728 1997-04-08
US60/042,825 1997-04-08
US4807097P 1997-05-30 1997-05-30
US4818497P 1997-05-30 1997-05-30
US4806897P 1997-05-30 1997-05-30
US60/048,070 1997-05-30
US60/048,184 1997-05-30
US60/048,068 1997-05-30

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1998/005311 Continuation-In-Part WO1998042738A1 (en) 1997-03-07 1998-03-19 87 human secreted proteins
PCT/US1998/010868 Continuation-In-Part WO1998054206A1 (en) 1997-03-07 1998-05-28 32 human secreted proteins

Related Child Applications (3)

Application Number Title Priority Date Filing Date
PCT/US1998/011422 Continuation-In-Part WO1998054963A2 (en) 1997-03-07 1998-06-04 207 human secreted proteins
US16678098A Continuation-In-Part 1997-03-07 1998-10-06
US10/100,683 Continuation-In-Part US7368531B2 (en) 1997-03-07 2002-03-19 Human secreted proteins

Publications (2)

Publication Number Publication Date
WO1998045712A2 WO1998045712A2 (en) 1998-10-15
WO1998045712A3 true WO1998045712A3 (en) 1998-12-03

Family

ID=27574292

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/006801 WO1998045712A2 (en) 1997-03-07 1998-04-07 20 human secreted proteins

Country Status (5)

Country Link
EP (1) EP0974058A2 (en)
JP (1) JP2001521383A (en)
AU (1) AU6952998A (en)
CA (1) CA2286303A1 (en)
WO (1) WO1998045712A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001018022A1 (en) * 1999-09-03 2001-03-15 Human Genome Sciences, Inc. 52 human secreted proteins
CA2305685A1 (en) * 1997-10-02 1999-04-15 Human Genome Sciences, Inc. 101 human secreted proteins
EP1445316A1 (en) * 1997-10-02 2004-08-11 Human Genome Sciences, Inc. Novel secreted protein
US7291712B2 (en) * 1998-06-25 2007-11-06 Genentech, Inc. Interleukin-8 homologous polypeptides and therapeutic uses thereof
CA2341326A1 (en) * 1998-09-03 2000-03-16 Takeda Chemical Industries, Ltd. Novel protein and process for producing the same
JP2002540763A (en) * 1999-02-10 2002-12-03 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド 33 human secreted proteins
WO2000055175A1 (en) * 1999-03-12 2000-09-21 Human Genome Sciences, Inc. 50 human secreted proteins
CA2365238A1 (en) * 1999-03-23 2000-09-28 Human Genome Sciences, Inc. 48 human secreted proteins
JP2002539841A (en) * 1999-03-26 2002-11-26 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド 50 human secreted proteins
EP1173461A4 (en) * 1999-03-26 2003-10-29 Human Genome Sciences Inc 50 human secreted proteins
CA2368482A1 (en) * 1999-03-26 2000-10-05 Craig A. Rosen 50 human secreted proteins
AU4331200A (en) * 1999-04-09 2000-11-14 Human Genome Sciences, Inc. 49 human secreted proteins
CA2374053A1 (en) * 1999-05-14 2000-11-23 Curagen Corporation Secreted polypeptides and corresponding polynucleotides
EP1194545A2 (en) * 1999-06-23 2002-04-10 Curagen Corporation Secreted polypeptides and corresponding polynucleotides
AU6229100A (en) * 1999-07-20 2001-02-05 Curagen Corporation Polypeptides and polynucleotides encoding same
US7001766B2 (en) 1999-07-20 2006-02-21 Curagen Corporation Nucleic acid sequences encoding human angiopoietin-like polypeptides
JP2003508030A (en) * 1999-08-11 2003-03-04 キュラジェン コーポレイション Novel polypeptide and nucleic acid encoding the same
JP2003531571A (en) * 1999-09-13 2003-10-28 キュラジェン コーポレイション Novel human proteins, polynucleotides encoding them, and methods of using them
CN100475842C (en) 1999-11-02 2009-04-08 巴登-符腾堡-黑森Drk血库有限公司 Molecular structure of RHD negative genes locus
CA2397334A1 (en) * 2000-01-14 2001-07-19 Incyte Genomics, Inc. Secreted proteins
US20050095587A1 (en) * 2000-02-24 2005-05-05 Panzer Scott R. Molecules for disease detection and treatment
WO2001062927A2 (en) * 2000-02-24 2001-08-30 Incyte Genomics Inc Polypeptides and corresponding polynucleotides for diagnostics and therapeutics
WO2001062918A2 (en) * 2000-02-24 2001-08-30 Incyte Genomics, Inc. Secretory polypeptides and corresponding polynucleotides
EP1368375A2 (en) * 2000-09-05 2003-12-10 Incyte Genomics, Inc. Secretory molecules
EP1364015A2 (en) * 2000-09-05 2003-11-26 Incyte Genomics, Inc. Molecules for diagnostics and therapeutics

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536637A (en) * 1993-04-07 1996-07-16 Genetics Institute, Inc. Method of screening for cDNA encoding novel secreted mammalian proteins in yeast
WO1997007198A2 (en) * 1995-08-11 1997-02-27 Genetics Institute, Inc. Dna sequences and secreted proteins encoded thereby

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536637A (en) * 1993-04-07 1996-07-16 Genetics Institute, Inc. Method of screening for cDNA encoding novel secreted mammalian proteins in yeast
WO1997007198A2 (en) * 1995-08-11 1997-02-27 Genetics Institute, Inc. Dna sequences and secreted proteins encoded thereby

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Database EMBL, entry EMEST8:HS898325, Accession number N94898 19 April 1996 88% identity with Seq.ID:11 nt.592-916 reverse orientation *
Database EMBL, entry EMEST8:HSA11678, Accession number AA011678 3 August 1996 99% identity with Seq.ID:11 nt.341-758 reverse orientation *
Database EMBL, entry EMEST8:HSA11715, Accession number AA011715 3 August 1996 99% identity with Seq.ID:11 nt.120-601 *

Also Published As

Publication number Publication date
AU6952998A (en) 1998-10-30
CA2286303A1 (en) 1998-10-15
JP2001521383A (en) 2001-11-06
WO1998045712A2 (en) 1998-10-15
EP0974058A2 (en) 2000-01-26

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