WO1998042317A3 - Implantable delivery device with self adjustable exit port - Google Patents

Implantable delivery device with self adjustable exit port Download PDF

Info

Publication number
WO1998042317A3
WO1998042317A3 PCT/US1998/004637 US9804637W WO9842317A3 WO 1998042317 A3 WO1998042317 A3 WO 1998042317A3 US 9804637 W US9804637 W US 9804637W WO 9842317 A3 WO9842317 A3 WO 9842317A3
Authority
WO
WIPO (PCT)
Prior art keywords
slit
beneficial agent
chamber
flow
delivery device
Prior art date
Application number
PCT/US1998/004637
Other languages
French (fr)
Other versions
WO1998042317A2 (en
Inventor
Juan C Gumucio
Keith E Dionne
James E Brown
Original Assignee
Alza Corp
Juan C Gumucio
Keith E Dionne
James E Brown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ338024A priority Critical patent/NZ338024A/en
Application filed by Alza Corp, Juan C Gumucio, Keith E Dionne, James E Brown filed Critical Alza Corp
Priority to JP54573998A priority patent/JP2002513414A/en
Priority to IL13204198A priority patent/IL132041A0/en
Priority to AT98911539T priority patent/ATE284679T1/en
Priority to DK98911539T priority patent/DK0969820T3/en
Priority to AU65472/98A priority patent/AU738417B2/en
Priority to EP98911539A priority patent/EP0969820B1/en
Priority to DE69828157T priority patent/DE69828157T2/en
Priority to CA002284929A priority patent/CA2284929C/en
Priority to KR1019997008725A priority patent/KR100572188B1/en
Publication of WO1998042317A2 publication Critical patent/WO1998042317A2/en
Publication of WO1998042317A3 publication Critical patent/WO1998042317A3/en
Priority to HK00104216A priority patent/HK1025049A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

A delivery device having a first chamber containing an osmotic agent, a membrane forming a wall of the first chamber through which fluid is imbibed by osmosis, a second chamber containing a beneficial agent to be delivered, and a moveable piston separating the two chambers. In fluid communiation with the second chamber is an orifice which comprises a slit valve. In the presence of pressure, the beneficial agent pushes through the slit, opening up a channel for delivery of the beneficial agent and creating flow. Because the slit remains closed in the absence of flow (or when the pressure is below the pressure required to open the slit), back diffusion of external fluids is eliminated when the slit is closed, which prevents contamination of the beneficial agent in the second chamber by external fluids. In addition, forward diffusion of the beneficial agent out of the capsule is prevented when the slit is closed. The slit valve opens only to the minimum dimension required to allow the flow generated by the osmostic pumping rate. The slit valve also allows a flow path to open around any obstruction in the slit valve to prevent clogging.
PCT/US1998/004637 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port WO1998042317A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AU65472/98A AU738417B2 (en) 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port
JP54573998A JP2002513414A (en) 1997-03-24 1998-03-10 Implantable delivery device with self-adjustable outlet port
IL13204198A IL132041A0 (en) 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port
AT98911539T ATE284679T1 (en) 1997-03-24 1998-03-10 IMPLANTABLE ADMINISTRATION DEVICE HAVING A SELF-ADJUSTING EXIT OPENING
DK98911539T DK0969820T3 (en) 1997-03-24 1998-03-10 Implantable dispensing device with a self-adjusting output port
NZ338024A NZ338024A (en) 1997-03-24 1998-03-10 Implantable osmotic delivery device with self adjustable exit port through which an agent is extruded
EP98911539A EP0969820B1 (en) 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port
KR1019997008725A KR100572188B1 (en) 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port
CA002284929A CA2284929C (en) 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port
DE69828157T DE69828157T2 (en) 1997-03-24 1998-03-10 IMPLANTABLE ADMINISTRATION DEVICE WITH A SELF-ADJUSTING OUTPUT OPENING
HK00104216A HK1025049A1 (en) 1997-03-24 2000-07-10 Implantable delivery device with self adjustable exit port.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3560797P 1997-03-24 1997-03-24
US60/035,607 1997-03-24

Publications (2)

Publication Number Publication Date
WO1998042317A2 WO1998042317A2 (en) 1998-10-01
WO1998042317A3 true WO1998042317A3 (en) 1998-12-30

Family

ID=21883714

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/004637 WO1998042317A2 (en) 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port

Country Status (20)

Country Link
US (2) US5997527A (en)
EP (1) EP0969820B1 (en)
JP (1) JP2002513414A (en)
KR (1) KR100572188B1 (en)
CN (2) CN1290590C (en)
AR (1) AR010407A1 (en)
AT (2) ATE284679T1 (en)
AU (1) AU738417B2 (en)
CA (1) CA2284929C (en)
CO (1) CO5021220A1 (en)
DE (2) DE69837894T2 (en)
ES (1) ES2232940T3 (en)
HK (2) HK1025049A1 (en)
IL (1) IL132041A0 (en)
MY (1) MY123359A (en)
NZ (1) NZ338024A (en)
PT (1) PT969820E (en)
TW (1) TW369419B (en)
WO (1) WO1998042317A2 (en)
ZA (1) ZA981610B (en)

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US9526763B2 (en) 2005-02-03 2016-12-27 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US9539200B2 (en) 2005-02-03 2017-01-10 Intarcia Therapeutics Inc. Two-piece, internal-channel osmotic delivery system flow modulator
US9572889B2 (en) 2008-02-13 2017-02-21 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents

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AU771132B2 (en) * 1998-12-31 2004-03-11 Intarcia Therapeutics, Inc. Osmotic delivery system having space efficient piston
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US7258869B1 (en) * 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
WO2002043800A2 (en) * 2000-11-29 2002-06-06 Durect Corporation Devices and methods for controlled delivery from a drug delivery device
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WO2001047595A1 (en) * 1999-12-27 2001-07-05 Alza Corporation Osmotic beneficial agent delivery system
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US6454759B2 (en) * 2000-02-28 2002-09-24 The Regents Of The University Of California Microfabricated injectable drug delivery system
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US6632217B2 (en) 2001-04-19 2003-10-14 Microsolutions, Inc. Implantable osmotic pump
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US7163688B2 (en) * 2001-06-22 2007-01-16 Alza Corporation Osmotic implant with membrane and membrane retention means
US20050101942A1 (en) * 2001-09-17 2005-05-12 Gillis Edward M. Device and method for accurate delivery of an active agent
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
MXPA04012976A (en) * 2002-06-17 2005-05-16 Alza Corp Osmotic delivery system with early zero order push power engine comprising an osmotic agent dispersed in the fluid vehicle.
BR0312429A (en) * 2002-06-26 2005-04-19 Alza Corp Minimal and volume efficient deformity piston for osmosis drug delivery systems
US20060009739A1 (en) * 2002-09-06 2006-01-12 Durect Corporation Implantable flow regulator with failsafe mode and reserve drug supply
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JP2006512370A (en) * 2002-12-19 2006-04-13 アルザ・コーポレーション A stable non-aqueous single phase gel and its formulation for delivery from an implantable device
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
CN1767815A (en) 2003-03-31 2006-05-03 阿尔萨公司 Non-aqueous single phase vehicles and formulations utilizing such vehicles
BRPI0408921A (en) * 2003-03-31 2006-03-28 Alza Corp osmotic distribution system and method for decreasing start times for osmotic distribution systems
KR20060017749A (en) * 2003-03-31 2006-02-27 알자 코포레이션 Osmotic pump with means for dissipating internal pressure
US8109922B2 (en) 2003-06-12 2012-02-07 Cordis Corporation Orifice device having multiple channels and multiple layers for drug delivery
US7211076B2 (en) 2003-06-12 2007-05-01 Cordis Corporation Medical device for fluid delivery having low fluid flow rate
US7108762B2 (en) 2003-06-12 2006-09-19 Cordis Corporation Method for manufacturing an orifice mechanism capable of low fluid flow rates
US6976983B2 (en) 2003-06-12 2005-12-20 Cordis Corporation Implantable device for delivering drugs using orifice mechanism capable of low fluid flow rates
US8491571B2 (en) 2003-06-12 2013-07-23 Cordis Corporation Orifice device having multiple channels with varying flow rates for drug delivery
US7678103B2 (en) 2003-06-12 2010-03-16 Cordis Corporation Orifice device for delivering drugs at low fluid flow rates
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US7731715B2 (en) 2004-12-10 2010-06-08 Edwards Lifesciences Corporation Ablative treatment of atrial fibrillation via the coronary sinus
JP2008528698A (en) * 2005-02-03 2008-07-31 インターシア セラピューティクス，インコーポレイティド Implantable interferon-containing devices
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US7959938B2 (en) * 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
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US8617143B2 (en) * 2006-12-07 2013-12-31 The Regents Of The University Of California Therapeutic agent delivery systems and devices
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US20090259214A1 (en) * 2008-04-09 2009-10-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Agent delivery device
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9526763B2 (en) 2005-02-03 2016-12-27 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US9539200B2 (en) 2005-02-03 2017-01-10 Intarcia Therapeutics Inc. Two-piece, internal-channel osmotic delivery system flow modulator
US9572889B2 (en) 2008-02-13 2017-02-21 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents

Also Published As

Publication number Publication date
CA2284929A1 (en) 1998-10-01
MY123359A (en) 2006-05-31
AR010407A1 (en) 2000-06-07
CN1251036A (en) 2000-04-19
DE69828157D1 (en) 2005-01-20
KR20010005657A (en) 2001-01-15
DE69837894D1 (en) 2007-07-19
AU738417B2 (en) 2001-09-20
TW369419B (en) 1999-09-11
ATE284679T1 (en) 2005-01-15
DE69837894T2 (en) 2008-01-31
EP0969820A2 (en) 2000-01-12
US6217906B1 (en) 2001-04-17
ES2232940T3 (en) 2005-06-01
AU6547298A (en) 1998-10-20
CN1139411C (en) 2004-02-25
HK1067077A1 (en) 2005-04-01
PT969820E (en) 2005-02-28
IL132041A0 (en) 2001-03-19
ZA981610B (en) 1999-08-26
HK1025049A1 (en) 2000-11-03
DE69828157T2 (en) 2005-12-22
CN1290590C (en) 2006-12-20
JP2002513414A (en) 2002-05-08
EP0969820B1 (en) 2004-12-15
CN1504242A (en) 2004-06-16
KR100572188B1 (en) 2006-04-18
CA2284929C (en) 2006-12-19
ATE363897T1 (en) 2007-06-15
US5997527A (en) 1999-12-07
NZ338024A (en) 2001-06-29
WO1998042317A2 (en) 1998-10-01
CO5021220A1 (en) 2001-03-27

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