WO1998037861A1 - Stannous fluoride gel with improved stand-up - Google Patents
Stannous fluoride gel with improved stand-up Download PDFInfo
- Publication number
- WO1998037861A1 WO1998037861A1 PCT/US1998/004256 US9804256W WO9837861A1 WO 1998037861 A1 WO1998037861 A1 WO 1998037861A1 US 9804256 W US9804256 W US 9804256W WO 9837861 A1 WO9837861 A1 WO 9837861A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- stannous
- fluoride
- parts
- silica
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
Definitions
- This invention relates to a dental gel containing stannous fluoride and more particularly to a process for producing a stannous fluoride gel having improved ribbon or stand-up characteristics when dispensed from a tube. These gels exhibit surprisingly good stannous ion and fluoride ion stability.
- Stannous fluoride (SnF 2 ) has been reported to be an effective agent for treating various oral conditions. The most important dental benefit imparted by stannous fluoride is the reduction of dental caries. Stannous fluoride-containing over-the-counter dentifrices have been classified by the U.S. Food & Drug Administration as therapeutic agents that provide protection against the development of dental caries. Early stannous fluoride dentifrices contained abrasive systems that reacted with fluoride making these products ineffective in reducing tooth decay. Significant progress in the development of new abrasives has led to the development of stannous fluoride dentifrices with significantly improved fluoride ion availability. However, the antibacterial stannous ion undergoes rapid hydrolysis and oxidation in aqueous based dentifrice's resulting in essentially no available stannous ion.
- the present invention relates to a stannous fluoride-containing gel comprising from about 0.3% to about 1.0% (by weight) stannous fluoride, from about 1.0% to about 10% (by weight) silica thickening agent and an anhydrous base.
- these gels also contain from about 0.01% to about 5% (by weight) of a gum system, e.g. hydroxyethyl cellulose.
- the present invention relates to an improved method for producing the above gels.
- This method uses mixing equipment commonly employed to manufacture dentifrices and provides a simplified processing scheme. This method involves (a) dissolving about 0.01 to about 5.0 parts gum system in an anhydrous base; (b) blending in from about 1 to about 10 parts silica thickening agent; and (c) adding from about 0.36 to about 0.46 parts stannous fluoride, wherein said anhydrous base in present in sufficient quantity such that the sum of all ingredient parts is 100.
- the present inventive improvement in gel stand-up, stannous/fluoride ion stability and processing techniques is predicated on the incorporation in the gel of a silica thickening agent.
- ribbon “stand-up” qualities relates to a gel ribbon which has an extrudable consistency such that the extruded ribbon of the gel, when dispensed on to the bristles of a toothbrush, will stand up on the top surface of the bristles for a time sufficient to allow full application of the gel to the teeth, e.g., time interval of least 0.5 to 1.0 minutes.
- Stannous fluoride-containing gel compositions of the present invention are generally comprised of from about 0.3% to about 1.0% (preferably 0.36% to about 0.46%) stannous fluoride, from about 1.0% to about 10.0% (preferably 3.0% to 8.0%) silica thickening agent and an anhydrous base.
- the anhydrous base is glycerin.
- preferred gels of the present invention also include from about 0.1% to about 5% of a gum system most preferably from about 0.3% to about 1.0% of a gum system.
- Thickening silica is used for three reasons. First, it increases the batch viscosity during processing ensuring good dispersion of the stannous fluoride (i.e., it prevents the stannous fluoride from settling to the bottom of the tank). Second, it provides a ribbon with very good stand-up characteristics. Third, I have observed that the resulting gel product exhibits surprisingly good stannous ion and fluoride ion stability.
- the thickening silica used in the practice of the present invention is a colloidal or fumed silica.
- silicas are in the form of finely divided particles, typically having a particle size less than about 4 microns.
- Fumed silica is typically made by combustion of silicon tetrachloride in hydrogen-oxygen furnaces. Fumed silica is commercially available under the trade name Aerosil from Degussa Corporation and under the trade name Cab-O-Sil ® from Cabot Corporation. A preferred fumed silica is Aerosil ® 200 from Degussa Corporation, Ridgefield Park, NJ. As described in the manufactures literature (Brochure PT 6-50-1-694H), Aerosil 200 has the following properties:
- a gum system may optionally be included in the SnF 2 , gels of the present invention at a concentration of from about 0.01% to about 5.0% by weight preferably from about 0.3% to about 1.0% by weight.
- the gum systems used in the practice of the present invention are food grade gums. Suitable gums are selected from the group consisting of: hydroxyethylcellulose.
- a preferred hydroxyethylcellulose is Natrosol ® 250 brand hydroxyethylcellulose manufactured by Aqualon Division of Hercules Inc., Wilmington, Delaware. Food grade, "LR" type hydroxyethylcellulose is the most preferred.
- Preferred hydroxyethylcellulose has a molecular weight of about 9.0 x 10 4 as estimate from intrinsic viscosity measurements as provided by the manufacturer.
- Preferred hydroxyethylcellulose has a low moisture content on a particle size such that at least 90% passes through a U.S. No. 40 mesh.
- Compositions of the present invention may also contain an effective amount of a flavor component which does not interfere with the stability of the stannous ions and fluoride ions.
- the flavor ingredient typically constitutes from about 0.05% to about 2.0% (preferably from about 0.1 to about 1.5%) of the gel composition.
- Suitable flavoring constituents are flavoring oils, e.g. oils of spearmint, peppermint, wintergreen, clove, methyl salicylate, cinaminic aldehydes and menthol.
- compositions of the present invention may also contain other typical toothpastes and gel additives provided that they do not interfere with the stability of the stannous ions and fluoride ions in the gel. These compositions are free of abrasives. Gel compositions of the present invention are prepared by
- the gum system is hydroxyethylcellulose
- the anhydrous base is glycerin (99.5%)
- the silica thickening agent is fumed silica.
- step (a) is conducted at a temperature above 120°C, typically about 150°C.
- the manufacturing method also includes an additional flavor addition step (d) which involves mixing from about 0.05 to about 2.0 parts of a flavor component that does not interfere with the stability of stannous ions or fluoride ions in the resulting composition.
- the composition is cooled to a temperature below 40°C prior to step (d).
- the most preferred method utilizes from about 0.1 parts to about 2.0 parts hydroxyethylcellulose, from about 3 to about 8 parts formed silica and from about 0.1 to about 1.5 parts flavor.
- Phase B • Transfer the gum phase (Phase A) into the Nauta mixer.
- the resulting product exhibits exceptional smoothness, clarity and is free from entrapped air.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU64473/98A AU6447398A (en) | 1997-02-28 | 1998-03-02 | Stannous fluoride gel with improved stand-up |
GB9920164A GB2336537B (en) | 1997-02-28 | 1998-03-02 | Stannous fluoride gel with improved stand-up |
BR9807793-7A BR9807793A (en) | 1997-02-28 | 1998-03-02 | Stannous fluoride gel composition, and process for producing stannous fluoride gel compositions |
DE19882146T DE19882146T1 (en) | 1997-02-28 | 1998-03-02 | Tin fluoride gel with improved level |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/808,902 | 1997-02-28 | ||
US08/808,902 US5871715A (en) | 1997-02-28 | 1997-02-28 | Stannous fluoride gel with improved stand-up |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998037861A1 true WO1998037861A1 (en) | 1998-09-03 |
Family
ID=25200060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/004256 WO1998037861A1 (en) | 1997-02-28 | 1998-03-02 | Stannous fluoride gel with improved stand-up |
Country Status (7)
Country | Link |
---|---|
US (1) | US5871715A (en) |
CN (1) | CN1248906A (en) |
AU (1) | AU6447398A (en) |
BR (1) | BR9807793A (en) |
DE (1) | DE19882146T1 (en) |
GB (1) | GB2336537B (en) |
WO (1) | WO1998037861A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008068323A1 (en) * | 2006-12-08 | 2008-06-12 | Glaxo Group Limited | Novel composition |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6592853B2 (en) * | 1999-03-10 | 2003-07-15 | Block Drug Company, Inc. | Dentin desensitizer containing stannous fluoride |
US20040072123A1 (en) * | 2002-05-08 | 2004-04-15 | Simonton Thomas C. | Capped syringe tip for dispensing and applying liquid or viscous materials |
DE60317894T2 (en) * | 2002-05-23 | 2008-11-13 | Dentsply International Inc. | DENTAL BAG AGAINST KARIES |
ITMI20031640A1 (en) * | 2003-08-08 | 2005-02-09 | Mipharm S P A | BASE FOR BIOADHESIVE GEL. |
JP4804845B2 (en) * | 2005-09-14 | 2011-11-02 | 東芝機械株式会社 | Clamping device |
US7727516B2 (en) * | 2006-02-28 | 2010-06-01 | The Procter & Gamble Company | Reduction of hair growth |
MX2008012908A (en) * | 2006-04-07 | 2008-10-13 | Procter & Gamble | Oral care regimens and kits. |
US9155769B2 (en) | 2006-07-07 | 2015-10-13 | The Procter & Gamble Co | Flavor oils with reduced dimethyl sulfoxide content and use in oral compositions |
AU2013201769B2 (en) * | 2006-07-07 | 2015-08-20 | The Procter & Gamble Company | Flavor oils with reduced sulfur content and use in oral care compositions |
US20080107612A1 (en) * | 2006-09-07 | 2008-05-08 | Simonton Thomas C | Anti-caries dental material |
WO2008080160A1 (en) * | 2006-12-22 | 2008-07-03 | Advent Solar, Inc. | Interconnect technologies for back contact solar cells and modules |
CA2945208C (en) * | 2014-05-07 | 2018-11-27 | The Procter & Gamble Company | Oral care compositions |
US20210177893A1 (en) * | 2019-12-11 | 2021-06-17 | Chun Nan LIN | Composition and method for treating and healing Medication-Related Osteonecrosis of the Jaw (MRONJ) |
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1997
- 1997-02-28 US US08/808,902 patent/US5871715A/en not_active Expired - Lifetime
-
1998
- 1998-03-02 WO PCT/US1998/004256 patent/WO1998037861A1/en active Application Filing
- 1998-03-02 DE DE19882146T patent/DE19882146T1/en not_active Withdrawn
- 1998-03-02 CN CN98802903A patent/CN1248906A/en active Pending
- 1998-03-02 BR BR9807793-7A patent/BR9807793A/en not_active Application Discontinuation
- 1998-03-02 AU AU64473/98A patent/AU6447398A/en not_active Abandoned
- 1998-03-02 GB GB9920164A patent/GB2336537B/en not_active Expired - Fee Related
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US4132772A (en) * | 1974-02-07 | 1979-01-02 | Colgate Palmolive Company | Dentifrice |
US4146605A (en) * | 1977-10-07 | 1979-03-27 | Lever Brothers Company | Aluminum compounds as anti-calculus agents |
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EP0038868A1 (en) * | 1980-04-29 | 1981-11-04 | Blendax-Werke R. Schneider GmbH & Co. | Toothpaste |
US4418057A (en) * | 1983-02-09 | 1983-11-29 | Scherer Laboratories, Inc. | Method of forming stable dental gel of stannous fluoride |
EP0216189A2 (en) * | 1985-09-14 | 1987-04-01 | Blendax GmbH | Oral hygiene composition |
EP0275706A2 (en) * | 1986-12-26 | 1988-07-27 | Lion Corporation | Oral composition |
GB2220141A (en) * | 1988-06-29 | 1990-01-04 | Church & Dwight Co Inc | Hydrogen peroxide releasing dentifrice |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008068323A1 (en) * | 2006-12-08 | 2008-06-12 | Glaxo Group Limited | Novel composition |
Also Published As
Publication number | Publication date |
---|---|
GB9920164D0 (en) | 1999-10-27 |
US5871715A (en) | 1999-02-16 |
AU6447398A (en) | 1998-09-18 |
CN1248906A (en) | 2000-03-29 |
BR9807793A (en) | 2000-02-15 |
DE19882146T1 (en) | 2000-01-05 |
GB2336537A (en) | 1999-10-27 |
GB2336537B (en) | 2001-08-08 |
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