WO1998032403A1 - Externally mounted medicated nasal dilator - Google Patents

Externally mounted medicated nasal dilator Download PDF

Info

Publication number
WO1998032403A1
WO1998032403A1 PCT/US1998/001513 US9801513W WO9832403A1 WO 1998032403 A1 WO1998032403 A1 WO 1998032403A1 US 9801513 W US9801513 W US 9801513W WO 9832403 A1 WO9832403 A1 WO 9832403A1
Authority
WO
WIPO (PCT)
Prior art keywords
dilator
nasal
substrate
aromatic
medication
Prior art date
Application number
PCT/US1998/001513
Other languages
French (fr)
Inventor
Peter J. Cronk
Kristen Cronk
Original Assignee
Cronk Peter J
Kristen Cronk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cronk Peter J, Kristen Cronk filed Critical Cronk Peter J
Priority to DE69805814T priority Critical patent/DE69805814T2/en
Priority to AU60436/98A priority patent/AU738977B2/en
Priority to BR9807099-1A priority patent/BR9807099A/en
Priority to JP53222098A priority patent/JP4574753B2/en
Priority to EP98903748A priority patent/EP1011552B1/en
Priority to AT98903748T priority patent/ATE218311T1/en
Priority to DK98903748T priority patent/DK1011552T3/en
Priority to CA002278714A priority patent/CA2278714C/en
Publication of WO1998032403A1 publication Critical patent/WO1998032403A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/01Orthopaedic devices, e.g. splints, casts or braces
    • A61F5/08Devices for correcting deformities of the nose ; Devices for enlarging the nostril, e.g. for breathing improvement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/08Inhaling devices inserted into the nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/08Inhaling devices inserted into the nose
    • A61M15/085Fixing means therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0016Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the smell sense

Definitions

  • This invention relates to dilators for easing the breathing of patients, and more particularly to medicated nasal dilators for preventing outer wall tissue of nasal passages from drawing in during breathing while providing medication to the patient.
  • Nasal dilators have been suggested for aiding breathing through the nose.
  • dilators There have been traditionally two types of dilators which have been effective in humans.
  • One type uses small rings or cages connected to a resilient structure. The rings are inserted into each nasal passage while the resilient structure spreads to provide unobstructed breathing. These dilators have been criticized because they are often uncomfortable to wear. Since the cages or rings are inserted into contact with sensitive nasal tissue, they have been known to cause irritation and itching.
  • Such devices are disclosed in U.S. Patent Number 3,710,799 to Caballero and the NOZOVENT dilator disclosed in Petruson D310,565.
  • nasal dilators which attach to the outer wall tissue of the nose and aide in preventing the inner nasal tissue from drawing in during breathing.
  • Such dilators include a flexible strip of material adhesively attached to a substrate. The dilator is fastened to the nose and the resilient material acts to keep the left and right nasal passages from drawing in or collapsing during inhalation. This usually occurs due to a malformation, such as a deviated septum or due to swelling during allergic reactions and the like.
  • Examples of nasal dilators which are adhesively attached to the outer skin of a human nose are disclosed in Doubek et al., U.S. 5,533,503 and Muchin, U.S. 5,546,929. While conventional nasal dilators are being used by a greater number of people, there is still a need to further improve the breathing of those individuals to a greater degree than can be established by mere mechanical manipulation of their nasal tissue. Summary of the Invention
  • the first group of preferred dilators include an elongated substrate having a pair longitudinal sides, a pair of transverse ends and top and bottom surfaces. Disposed on the bottom surface of the substrate is a pressure sensitive adhesive.
  • the substrate also includes a resilient member bonded to its surface to provide a gentle expanding force to a nasal wall tissue when the dilator is adhesively attached to a nose.
  • an aromatic medication is disposed on a portion of the dilator so that it can be inhaled through the nose of the wearer during breathing. This invention combines the spring action of adhesively applied nasal dilators with inhaleable aromatics.
  • a method of substantially preventing the wall tissue of a nose from drawing in during breathing includes providing a nasal dilator including a substrate having disposed thereon a pressure sensitive adhesive layer on a first surface and a resilient member bonded to a second surface. Impregnated into the substrate is an aromatic medication for helping the patient breathe easier. The method further includes applying the pressure sensitive adhesive layer across a nose whereby the resilient member provides a gentle expanding force to the nasal wall tissue while the aromatic medication is being inhaled.
  • transdermal medications and resilient scrims or sheet layers bonded to the substrate for minimizing the expense of continuous processing of the dilators of this invention.
  • FIG. 1 is a partial front perspective view of a man wearing the preferred nasal dilator of this invention
  • FIG. 2 is a top planar view the nasal dilator of this invention with a partial peel back view of the adhesive layer;
  • FIG. 3 is a side elevation, cross-sectional, exploded view of the nasal dilator of FIG. 2;
  • FIG. 4 is a top planar view of a preferred resilient member, including the periphery of the substrate of the nasal dilator in phantom; and
  • FIG. 5 is a top planar view of an alternative resilient member consisting of a reinforcing scrim also depicting the periphery of the substrate in phantom.
  • FIGS. 1-3 there shown a preferred nasal dilator 100 sized to fit across the nose of the wearer so as to engage the outer wall tissue of the left and right nasal passages of the wearer. As shown in FIGS.
  • the nasal dilator 100 includes an elongated substrate 30 having a pair of longitudinal sides, a pair of transverse ends and top and bottom surfaces thereon. Disposed on a bottom surface of the substrate 30 is an adhesive layer 32 for permitting easy attachment to the wearer's skin. Also attached to the substrate is a resilient member 60 which provides a gentle expanding force to the nasal wall tissue when the dilator is adhesively attached to the nose. Finally, an aromatic medication 50 is disposed on a portion of the dilator so as to be inhaled through the nose of the wearer during breathing.
  • the dilator 100 can include a backing layer 40. The backing layer 40 and resilient member 60 are desirably bonded to the substrate 30 using pressure sensitive adhesive layers 42 and 62.
  • the aromatic medication can be disposed on any surface of the dilator 100.
  • the aromatic medication 50 is disposed on an absorbent layer portion of the dilator 100.
  • the absorbent layer portion can be a separate absorbent layer or a portion of the elongated substrate 30 or backing layer 40.
  • the aromatic medication can be disposed in one of the adhesive layers in an admixture or segregated form.
  • a release paper strip 10 can be added over the pressure sensitive adhesive layer 32 prior to packaging the strip for sale.
  • the elongated substrate 30 of this invention may include any thin, flexible, breathable material for maximizing comfort. Preferably this material permits the passage of air and moisture vapor, such as perspiration.
  • the elongated substrate can include, for example, a woven or non-woven fabric material, such as non-woven, polyester fabric.
  • a woven or non-woven fabric material such as non-woven, polyester fabric.
  • the elongated substrate 30 can include a thermoplastic woven or non-woven fabric, such as spun-bonded polyethylene or polypropylene.
  • the substrate 30 can also be treated with the aromatic medication 50 of this invention, along with a hydrophilic or hydrophobic additive for absorbing or repelling sweat or moisture on a selective basis.
  • Adhesive compositions suitable for nasal dilators include water-based pressure- sensitive adhesives, such as acrylate adhesives, thermoplastics "hot melt” adhesives, two- sided adhesive tape, elastomer-based adhesives, and acrylic adhesives. Good examples include 3M1509 double-sided medical tape provided by 3M Inc., St. Paul, Minnesota.
  • the resilient member 60 of this invention preferably includes one or more spring strips 60a which can be die-cut from spring ribbon material.
  • spring ribbon material include biaxially oriented polyester that is approximately 0.01 inches thick, but polyethylene or polypropylene strips of like thickness would also provide expanding force to the dilator 100. Fiber additions to the resin of the spring strips 60a, such as, glass, graphite, carbon or boron will also improve resiliency.
  • a resilient layer such as scrim 60b can be disposed within, or substantially along the perimeter 11 of the substrate 30 or outer peripheral region of the dilator 100.
  • the resilient layer can be a woven oriented mat, fabric or material, or a non- woven mat material of fibers which are either adhesively or melt bonded together.
  • Such fibers can include thermoplastic or thermosetting polymers.
  • thermoplastic fibers such as nylon, polyethylene, and polyester fibers, for example SPECTRA or COMPET fibers sold by Allied Signal Corp., Kevlar® 29, 49 or 149 aramid fibers sold by DuPont, glass, such as E-glass and S-Glass fibers, graphite fibers, carbon fibers, boron fibers, or combinations of these fibers.
  • the resilient member whether including spring strips 60a or a resilient scrim 60b or sheet layer (not shown) is preferably joined together in a webbing operation either by melt bonding, adhesive bonding or ultrasonic bonding. In conventional operations, a ribbon of resilient material and substrate material are adhesively joined together as they are fed into an overlapping position in a die or roller.
  • Adhesive layers 42 and 62 are used to join the backing layer, resilient member 60 and elongated substrate 30 together prior to die-cutting to form the final periphery 11 of the dilator 100.
  • the adhesive layers 42, 62 and 32 can be applied by spray, roll or knife, as is customary in the web-processing industry.
  • the resilient layer such as scrim 60b or a sheet layer, as opposed to a pair of discrete spring strips 60a of this invention, is the elimination of a careful placement operation prior to die-cutting. Such an expensive step becomes unnecessary, since the resilient layer preferably conforms generally to the perimeter 11 of the final die-cut dilator. This can eliminate waste and minimize much of the expense of the webbing operation. It also provides for a more uniform spring action along most or all of the surface area of the dilator 100. Additionally, this invention contemplates employing thermoplastic materials in the backing layer 40 and substrate 30, and alternatively, with respect to the resilient member 60 or layer.
  • this invention enables inexpensive melt-bonding of the layers of material, with heat and pressure, to provide a composite nasal dilator structure. Melt-bonding could eliminate the need of additional adhesive layers 42 and 62 and provide a greater structural integrity to the dilator no matter what form of resilient member is employed.
  • resilient scrim 60b is ideally suited for thermoplastic bonding of layers since it has pores for permitting softened thermoplastic material to bond between the fibers or filaments, further increasing the strength of the dilator 100, without requiring a lot of material.
  • the dilator can include an aromatic medication 50, transdermal medication, or both.
  • aromatic medications include camphor, eucalyptus oil, peppermint oil, menthol, methy salicylate, bornyl acetate, lavender oil, or a combination of these.
  • Transdermal decongestants and antihistamines are also available, such as diphenhydramine and triprolidine transdermal antihistamine, available from Proctor and Gamble Co., Inc., Cincinnati, Ohio; others include ephedrine, dimethindene, epinastine, emedastine, and clonidine.
  • aromatic and transdermal medications can be mixed within adhesive layer 32, as in, for example, a dispersion-type transdermal patch formulation from acrylate copolymer adhesive or a lecithin gel based matrix.
  • a rate controlling membrane could be used, such as Eudragit RL-100.
  • this invention provides improved nasal dilators which include possibly synergistic combinations of mechanical and medicated aromatic or transdermal compositions. Also included are material processing improvements which add improved functionality and reduce the overall cost of the product.
  • the dilators and methods of this invention are useful for helping individuals with deviated septums and athletes who desire more oxygen during a performance.

Abstract

An externally mounted nasal dilator (100) and method of use comprising an elongated substrate (30), a pressure sensitive adhesive layer (32) disposed on the bottom surface of the substrate, a resilient member (60) bonded to the substrate, and a medication (50), aromatic or transdermal, disposed on a portion of the dilator.

Description

EXTERNALLY MOUNTED MEDICATED NASAL DILATOR
Field of the Invention
This invention relates to dilators for easing the breathing of patients, and more particularly to medicated nasal dilators for preventing outer wall tissue of nasal passages from drawing in during breathing while providing medication to the patient.
Background of the Invention
Nasal dilators have been suggested for aiding breathing through the nose. There have been traditionally two types of dilators which have been effective in humans. One type uses small rings or cages connected to a resilient structure. The rings are inserted into each nasal passage while the resilient structure spreads to provide unobstructed breathing. These dilators have been criticized because they are often uncomfortable to wear. Since the cages or rings are inserted into contact with sensitive nasal tissue, they have been known to cause irritation and itching. Such devices are disclosed in U.S. Patent Number 3,710,799 to Caballero and the NOZOVENT dilator disclosed in Petruson D310,565.
More recently, advancements have been made in nasal dilators which attach to the outer wall tissue of the nose and aide in preventing the inner nasal tissue from drawing in during breathing. Such dilators include a flexible strip of material adhesively attached to a substrate. The dilator is fastened to the nose and the resilient material acts to keep the left and right nasal passages from drawing in or collapsing during inhalation. This usually occurs due to a malformation, such as a deviated septum or due to swelling during allergic reactions and the like. Examples of nasal dilators which are adhesively attached to the outer skin of a human nose are disclosed in Doubek et al., U.S. 5,533,503 and Muchin, U.S. 5,546,929. While conventional nasal dilators are being used by a greater number of people, there is still a need to further improve the breathing of those individuals to a greater degree than can be established by mere mechanical manipulation of their nasal tissue. Summary of the Invention
Nasal dilators and methods of easing breathing are provided by this invention. The first group of preferred dilators include an elongated substrate having a pair longitudinal sides, a pair of transverse ends and top and bottom surfaces. Disposed on the bottom surface of the substrate is a pressure sensitive adhesive. The substrate also includes a resilient member bonded to its surface to provide a gentle expanding force to a nasal wall tissue when the dilator is adhesively attached to a nose. In an important improvement over the prior art, an aromatic medication is disposed on a portion of the dilator so that it can be inhaled through the nose of the wearer during breathing. This invention combines the spring action of adhesively applied nasal dilators with inhaleable aromatics. Such an accommodation has the potential to produce synergistic benefits for patients who have not been entirely satisfied by either non- medicated dilators, or over-the-counter decongestant medication, some of which can cause drowsiness. In another embodiment of this invention, a method of substantially preventing the wall tissue of a nose from drawing in during breathing is provided. The method includes providing a nasal dilator including a substrate having disposed thereon a pressure sensitive adhesive layer on a first surface and a resilient member bonded to a second surface. Impregnated into the substrate is an aromatic medication for helping the patient breathe easier. The method further includes applying the pressure sensitive adhesive layer across a nose whereby the resilient member provides a gentle expanding force to the nasal wall tissue while the aromatic medication is being inhaled.
Further embodiments of this invention include transdermal medications and resilient scrims or sheet layers bonded to the substrate for minimizing the expense of continuous processing of the dilators of this invention. Brief Description of the Drawings
The accompanying drawings illustrate preferred embodiments of the invention as well as other information pertinent to the disclosure, in which:
FIG. 1 : is a partial front perspective view of a man wearing the preferred nasal dilator of this invention;
FIG. 2: is a top planar view the nasal dilator of this invention with a partial peel back view of the adhesive layer;
FIG. 3: is a side elevation, cross-sectional, exploded view of the nasal dilator of FIG. 2; FIG. 4: is a top planar view of a preferred resilient member, including the periphery of the substrate of the nasal dilator in phantom; and
FIG. 5: is a top planar view of an alternative resilient member consisting of a reinforcing scrim also depicting the periphery of the substrate in phantom.
Detailed Description of the Invention This invention provides nasal dilators and methods for substantially preventing a nasal wall tissue of a nose from drawing in during breathing. As used herein, the term "aromatic" medication refers to substances and compounds which can be consumed by inhaling through the nose, such as a medicated vapor or gas. Such substances should have some efficacy in helping patients breathe easier or better. With reference to the figures and in particular, FIGS. 1-3 thereof, there shown a preferred nasal dilator 100 sized to fit across the nose of the wearer so as to engage the outer wall tissue of the left and right nasal passages of the wearer. As shown in FIGS. 2- 3 the nasal dilator 100 includes an elongated substrate 30 having a pair of longitudinal sides, a pair of transverse ends and top and bottom surfaces thereon. Disposed on a bottom surface of the substrate 30 is an adhesive layer 32 for permitting easy attachment to the wearer's skin. Also attached to the substrate is a resilient member 60 which provides a gentle expanding force to the nasal wall tissue when the dilator is adhesively attached to the nose. Finally, an aromatic medication 50 is disposed on a portion of the dilator so as to be inhaled through the nose of the wearer during breathing. In further embodiments of this invention, the dilator 100 can include a backing layer 40. The backing layer 40 and resilient member 60 are desirably bonded to the substrate 30 using pressure sensitive adhesive layers 42 and 62. As shown in FIG. 3 the aromatic medication can be disposed on any surface of the dilator 100. Preferably the aromatic medication 50 is disposed on an absorbent layer portion of the dilator 100. The absorbent layer portion can be a separate absorbent layer or a portion of the elongated substrate 30 or backing layer 40. Alternatively, the aromatic medication can be disposed in one of the adhesive layers in an admixture or segregated form. Finally, a release paper strip 10 can be added over the pressure sensitive adhesive layer 32 prior to packaging the strip for sale.
The elongated substrate 30 of this invention may include any thin, flexible, breathable material for maximizing comfort. Preferably this material permits the passage of air and moisture vapor, such as perspiration. The elongated substrate can include, for example, a woven or non-woven fabric material, such as non-woven, polyester fabric. One good example is a fabric produced by DuPont E. I. de Nemours & Co., Inc. under the trademark Sontara®. Alternatively, the elongated substrate 30 can include a thermoplastic woven or non-woven fabric, such as spun-bonded polyethylene or polypropylene. The substrate 30 can also be treated with the aromatic medication 50 of this invention, along with a hydrophilic or hydrophobic additive for absorbing or repelling sweat or moisture on a selective basis.
Attached to the substrate 30 on the nose skin-facing side or bottom surface of the substrate 30 is an adhesive layer 32. This adhesive layer, along with optional adhesive layers 62 and 42 can be made of a pressure sensitive biocompatible adhesive material. As used herein, "pressure-sensitive" refers to any releasable adhesive or releasable tenacious means. Adhesive compositions suitable for nasal dilators include water-based pressure- sensitive adhesives, such as acrylate adhesives, thermoplastics "hot melt" adhesives, two- sided adhesive tape, elastomer-based adhesives, and acrylic adhesives. Good examples include 3M1509 double-sided medical tape provided by 3M Inc., St. Paul, Minnesota. This product is a double-sided transparent polyethylene film, coated on both sides with a hypoallergenic, pressure-sensitive acrylate adhesive, supplied on a paper liner. Of course, adhesive layers 62 and 42 need not be a pressure-sensitive type at all, since once the resilient member 60 and backing layer 40 are adhered to the substrate 30, it is undesirable for these layers to separate during application or removal of the dilator from the nose. The resilient member 60 of this invention preferably includes one or more spring strips 60a which can be die-cut from spring ribbon material. Good examples of spring ribbon material include biaxially oriented polyester that is approximately 0.01 inches thick, but polyethylene or polypropylene strips of like thickness would also provide expanding force to the dilator 100. Fiber additions to the resin of the spring strips 60a, such as, glass, graphite, carbon or boron will also improve resiliency.
Alternatively, as shown in FIG. 5, a resilient layer, such as scrim 60b can be disposed within, or substantially along the perimeter 11 of the substrate 30 or outer peripheral region of the dilator 100. The resilient layer can be a woven oriented mat, fabric or material, or a non- woven mat material of fibers which are either adhesively or melt bonded together. Such fibers can include thermoplastic or thermosetting polymers.
Examples include thermoplastic fibers, such as nylon, polyethylene, and polyester fibers, for example SPECTRA or COMPET fibers sold by Allied Signal Corp., Kevlar® 29, 49 or 149 aramid fibers sold by DuPont, glass, such as E-glass and S-Glass fibers, graphite fibers, carbon fibers, boron fibers, or combinations of these fibers. The resilient member, whether including spring strips 60a or a resilient scrim 60b or sheet layer (not shown) is preferably joined together in a webbing operation either by melt bonding, adhesive bonding or ultrasonic bonding. In conventional operations, a ribbon of resilient material and substrate material are adhesively joined together as they are fed into an overlapping position in a die or roller. Adhesive layers 42 and 62 are used to join the backing layer, resilient member 60 and elongated substrate 30 together prior to die-cutting to form the final periphery 11 of the dilator 100. The adhesive layers 42, 62 and 32 can be applied by spray, roll or knife, as is customary in the web-processing industry.
An important advantage of the resilient layer, such as scrim 60b or a sheet layer, as opposed to a pair of discrete spring strips 60a of this invention, is the elimination of a careful placement operation prior to die-cutting. Such an expensive step becomes unnecessary, since the resilient layer preferably conforms generally to the perimeter 11 of the final die-cut dilator. This can eliminate waste and minimize much of the expense of the webbing operation. It also provides for a more uniform spring action along most or all of the surface area of the dilator 100. Additionally, this invention contemplates employing thermoplastic materials in the backing layer 40 and substrate 30, and alternatively, with respect to the resilient member 60 or layer. When thermoplastic materials are used, this invention enables inexpensive melt-bonding of the layers of material, with heat and pressure, to provide a composite nasal dilator structure. Melt-bonding could eliminate the need of additional adhesive layers 42 and 62 and provide a greater structural integrity to the dilator no matter what form of resilient member is employed. However, resilient scrim 60b is ideally suited for thermoplastic bonding of layers since it has pores for permitting softened thermoplastic material to bond between the fibers or filaments, further increasing the strength of the dilator 100, without requiring a lot of material. In a further important aspect of this invention, the dilator can include an aromatic medication 50, transdermal medication, or both. Good examples of aromatic medications include camphor, eucalyptus oil, peppermint oil, menthol, methy salicylate, bornyl acetate, lavender oil, or a combination of these. Transdermal decongestants and antihistamines are also available, such as diphenhydramine and triprolidine transdermal antihistamine, available from Proctor and Gamble Co., Inc., Cincinnati, Ohio; others include ephedrine, dimethindene, epinastine, emedastine, and clonidine. These aromatic and transdermal medications can be mixed within adhesive layer 32, as in, for example, a dispersion-type transdermal patch formulation from acrylate copolymer adhesive or a lecithin gel based matrix. Alternatively, a rate controlling membrane could be used, such as Eudragit RL-100.
From the foregoing, it can be realized that this invention provides improved nasal dilators which include possibly synergistic combinations of mechanical and medicated aromatic or transdermal compositions. Also included are material processing improvements which add improved functionality and reduce the overall cost of the product. The dilators and methods of this invention are useful for helping individuals with deviated septums and athletes who desire more oxygen during a performance. Although various embodiments have been illustrated, this is for the purpose of describing, but not limiting the invention. Various modifications which will become apparent to one skilled in the art, are within the scope of this invention described in the attached claims.

Claims

We Claim:
1. A nasal dilator 100 for substantially preventing a nasal wall tissue of a nose from drawing in during breathing, characterized by: an elongated substrate 30 having a pair of longitudinal sides, a pair of transverse ends, and top and bottom surfaces thereon; a pressure sensitive adhesive layer 32 disposed on said bottom surface of said substrate; a resilient member 60 bonded to said substrate to provide a gentle expanding force to said nasal wall tissue when said dilator 100 is adhesively attached to said nose; and an aromatic medication 50 disposed on a portion of said dilator 100, said aromatic medication 50 being inhaled through said nose during breathing.
2. A nasal dilator of Claim 1 wherein said resilient member includes a resilient band, resilient fibers or a resilient layer.
3. The nasal dilator of Claim 1 wherein said aromatic medication includes one or more of: camphor, eucalyptus oil, peppermint oil, menthol, methyl salicylate, bornyl acetate, lavender oil, or a combination thereof.
4. The nasal dilator of Claim 1 further including an aromatic antihistamine or decongestant.
5. The nasal dilator of Claim 1 further including a fibrous absorbent layer bonded to said substrate.
6. The nasal dilator of Claim 5 further including a transdermal antihistamine or decongestant.
7. The nasal dilator of any one of claims 1-6 wherein said aromatic medication is mixed within said adhesive layer.
8. The method of Claim 1 wherein said aromatic medication is substantially activated upon being warmed by body heat.
9. A nasal dilator 100 for substantially preventing a nasal wall tissue of a nose from drawing in during breathing, characterized by: an elongated substrate 30 having a pair of longitudinal sides, a pair of transverse ends, and a top and bottom surface thereon; a pressure sensitive adhesive layer 32 disposed on said bottom surface of said substrate; a resilient member 60 bonded to said substrate to provide a gentle expanding force to said nasal wall tissue when said dilator is adhesively attached to said nose; and a transdermal medication 50 disposed on said bottom surface for providing breathing relief to said patient.
10. The nasal dilator of Claim 9 wherein said transdermal medication includes an antihistamine or decongestant.
AMENDED CLAIMS
[received by the International Bureau on 27 May 1998 (27.05.98) ; original claims 1-10 replaced by amended claims 1.-10 (2 pages)]
1. An externally mounted nasal dilator 100 for substantially preventing a nasal wall tissue of a nose from drawing in during breathing, characterized by: an elongated flexible, resilient member having a top and a bottom surface thereon; a pressure sensitive adhesive layer 32 disposed on said bottom surface of said resilient member; said resilient member providing a gentle expanding force to said nasal wall tissue when said dilator 100 is adhesively attached to said nose by said pressure sensitive adhesive layer 32; and an aromatic or transdermal substance 50, or both, disposed on said dilator.
2. A nasal dilator of Claim 1 wherein said resilient member includes a ribbon, fibers, a woven layer, a non-woven layer, a scrim, a composite, a sheet layer, or a combination thereof.
3. The nasal dilator of Claim 1 wherein said aromatic substance includes one or more of: camphor, eucalyptus oil, peppermint oil, menthol, methyl salicylate, bornyl acetate, lavender oil, or a combination thereof.
4. The nasal dilator of Claim 1 wherein said aromatic or transdermal substance comprises an antihistamine or decongestant.
5. The nasal dilator of Claim 1 wherein said resilient member includes a fibrous absorbent layer portion.
6. The nasal dilator of any one of claims 1 -5 wherein said aromatic or transdermal substance is mixed within said adhesive layer.
7. The method of Claim 1 wherein said aromatic or transdermal substance is substantially activated upon being warmed by body heat.
8. A method of easing a patient's breathing by adhesively applying an elongated flexible substrate 30 to an external nasal wall tissue of the patient, said substrate 30 having a pair of longitudinal sides, a pair of transverse ends, and top and bottom surfaces thereon, said substrate 30 including a pressure sensitive adhesive layer 32 disposed on said bottom surface; said method characterized by: providing an aromatic or transdermal substance 50 on said substrate 30 for easing said patient's breathing.
9. The method of Claim 8, wherein said medication is disposed within an absorbent portion of said substrate, a dispersion-type transdermal patch formulation, a gel based matrix or a rate-controlling membrane.
10. The method of Claim 8, wherein said medication includes an antihistamine, decongestant, or aromatic medication.
PCT/US1998/001513 1997-01-29 1998-01-28 Externally mounted medicated nasal dilator WO1998032403A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE69805814T DE69805814T2 (en) 1997-01-29 1998-01-28 PRESENTED NASAL DILATOR WITH APPLIED MEDICINE
AU60436/98A AU738977B2 (en) 1997-01-29 1998-01-28 Externally mounted medicated nasal dilator
BR9807099-1A BR9807099A (en) 1997-01-29 1998-01-28 Externally mounted medicated nasal dilator
JP53222098A JP4574753B2 (en) 1997-01-29 1998-01-28 Outer shape medicinal nasal dilator
EP98903748A EP1011552B1 (en) 1997-01-29 1998-01-28 Externally mounted medicated nasal dilator
AT98903748T ATE218311T1 (en) 1997-01-29 1998-01-28 EXTERNALLY INSERTED NASAL DILATOR WITH APPLIED MEDICATION
DK98903748T DK1011552T3 (en) 1997-01-29 1998-01-28 Externally positioned medicated nasal dilator
CA002278714A CA2278714C (en) 1997-01-29 1998-01-28 Externally mounted medicated nasal dilator

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/791,760 US5706800A (en) 1997-01-29 1997-01-29 Medicated nasal dilator
US08/791,760 1997-01-29

Publications (1)

Publication Number Publication Date
WO1998032403A1 true WO1998032403A1 (en) 1998-07-30

Family

ID=25154708

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/001513 WO1998032403A1 (en) 1997-01-29 1998-01-28 Externally mounted medicated nasal dilator

Country Status (14)

Country Link
US (2) US5706800A (en)
EP (1) EP1011552B1 (en)
JP (2) JP4574753B2 (en)
CN (1) CN1259893C (en)
AT (1) ATE218311T1 (en)
AU (1) AU738977B2 (en)
BR (1) BR9807099A (en)
CA (1) CA2278714C (en)
DE (1) DE69805814T2 (en)
DK (1) DK1011552T3 (en)
ES (1) ES2178151T3 (en)
PT (1) PT1011552E (en)
WO (1) WO1998032403A1 (en)
ZA (1) ZA98144B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100341111B1 (en) * 1999-06-07 2002-06-20 홍중기 nasal dilator
JP2011101809A (en) * 1998-06-18 2011-05-26 J Cronk Peter Nasal dilator
US8834514B2 (en) 2006-08-30 2014-09-16 Xennovate Medical Llc Resilient band medical device
US8852224B2 (en) 1997-01-29 2014-10-07 Peter J. Cronk Therapeutic delivery system

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5961537A (en) * 1996-03-05 1999-10-05 Gould; David L. Nose foreshortener and external nasal dilator
US6080179A (en) * 1996-03-05 2000-06-27 Gould; David L. Resiliently retracting external nasal dilator
JP2000513956A (en) * 1996-04-16 2000-10-24 デ・ヴォス,トーステン Nasal dilator and method of manufacturing the same
US5890486A (en) * 1996-12-20 1999-04-06 The Procter & Gamble Company Thermal nasal dilator and method of treatment for relief of nasal congestion and other symptoms associated with common cold and allergies
US5706800A (en) 1997-01-29 1998-01-13 Cronk; Peter J. Medicated nasal dilator
US6769428B2 (en) 1997-01-29 2004-08-03 Peter J. Cronk Adhesively applied external nasal strips and dilators containing medications and fragrances
US6550474B1 (en) * 1997-01-29 2003-04-22 Cns, Inc. Microencapsulated fragrances and methods of coating microcapsules
US6033422A (en) * 1997-04-21 2000-03-07 Winease Llc Nasal support device for domestic mammals and method
US7175645B1 (en) * 1997-04-21 2007-02-13 Winease Llc Nasal support device for domestic mammals and method
US5913873A (en) * 1997-04-21 1999-06-22 Winease Llc Nasal support device for domestic mammals and method
US6898550B1 (en) * 1997-10-02 2005-05-24 Fitsense Technology, Inc. Monitoring activity of a user in locomotion on foot
US5947119A (en) * 1997-10-31 1999-09-07 Reznick; Jerald M. Therapeutic process and apparatus for nasal passages
WO1999022678A1 (en) * 1997-11-04 1999-05-14 Clear Sport Ltd. Improvements relating to adhesive devices such as strips, tapes, patches and the like, for application to the human body
US6098616A (en) * 1998-03-13 2000-08-08 Acutek International Non-linear nasal dilator
USD427370S (en) * 1998-06-15 2000-06-27 Avon Products, Inc. Nose strip
US6295982B1 (en) * 1998-07-01 2001-10-02 Fred Dewitt Reed, Jr. Apparatus for and methods of administering volatile substances into an inhalation flow path
DE69835035T2 (en) * 1998-07-01 2007-01-11 Jr. F. Dewitt Las Vegas Reed Apparatus and method for administering volatile substances in an inhalation flow path
EP1033118B1 (en) 1999-03-02 2005-07-20 3M Innovative Properties Company Nasal dilator
US6352548B1 (en) * 1999-08-23 2002-03-05 Winease Llc Nasal support device for animals and method
US6676681B1 (en) 1999-11-15 2004-01-13 Winease Llc Reusable nasal support devices for animals and methods
US6494204B1 (en) 2000-06-23 2002-12-17 Pedro D. Ponce Nasal medication administering device
EP1515774B1 (en) * 2001-12-31 2012-06-20 Cns, Inc. Nasal devices including dilation and user communication
US6863066B2 (en) * 2002-01-28 2005-03-08 Ronald Jack Ogle Adjustable nasal dilator filter
US6688305B1 (en) * 2002-05-03 2004-02-10 Perry Doreen L Therapeutic aid
US7108198B2 (en) * 2002-10-25 2006-09-19 Altadonna Jr James Nasal aromatherapy dispenser clip
US20040194784A1 (en) * 2003-04-01 2004-10-07 Archie Bertrand Respiratory particulate filter
US20040237967A1 (en) * 2003-05-31 2004-12-02 Davis Ralph A. Nasal breathing apparatus
US7114495B2 (en) * 2004-05-05 2006-10-03 Silver Eagle Labs Inc. Nasal strip with variable spring rate
US20060045849A1 (en) * 2004-08-24 2006-03-02 Farhan Taghizadeh Method of customizing the fragrance of nasal medications
JP2006104076A (en) * 2004-09-30 2006-04-20 Kobayashi Pharmaceut Co Ltd Composition for nasal foramen
US20060266360A1 (en) * 2005-05-27 2006-11-30 Alisa Noce Nasal dilator
US20060266367A1 (en) * 2005-05-27 2006-11-30 Alisa Noce Nasal dilator
US7798141B2 (en) * 2005-08-05 2010-09-21 Veeder Matthew P Manually adjustable nasal cavity dilator
NZ567882A (en) * 2005-11-07 2011-04-29 Cns Spring force element for nasal dilators with and adhesive side and a force-applying side with delayed action
US7837649B1 (en) 2005-11-07 2010-11-23 Aboff Clifford S Nasal clip for aromatic substances
US7878197B2 (en) * 2006-02-09 2011-02-01 Frank L. Christy Nasal comfort devices and methods
USD753294S1 (en) 2006-04-27 2016-04-05 Innovative Medical Equipment, Llc Nasal dilator
US8047201B2 (en) 2006-04-27 2011-11-01 Innovation Alley Design, Llc Nasal dilator
US20080097517A1 (en) 2006-10-23 2008-04-24 Webtec Converting, Llc. External Nasal Dilator and Methods of Manufacture
US9730828B2 (en) 2007-02-06 2017-08-15 Corbett-Lair Inc. Economical nasal dilator and method of manufacture
US8062329B2 (en) 2007-04-21 2011-11-22 Joseph Vincent Ierulli Nasal dilator with means to direct resilient properties
US8584671B2 (en) * 2007-02-06 2013-11-19 Corbett-Lair Inc. Economical nasal dilator and method of manufacture
US9730827B2 (en) 2007-02-06 2017-08-15 Corbett-Lair Inc. Economical nasal dilator and method of manufacture
US8858587B2 (en) * 2008-03-12 2014-10-14 Corbett Lair, Inc. Nasal dilator and method of manufacture
US20080223371A1 (en) * 2007-03-14 2008-09-18 Guillory Samuel L Nose guard mask
US20180021163A9 (en) 2007-04-21 2018-01-25 Corbett Lair, Inc. Nasal Dilator With Means To Direct Resilient Properties
US8342173B2 (en) * 2007-07-19 2013-01-01 Silver Eagle Labs Inc. Nasal dilator with cushion layer and variable spring rate
GB0720373D0 (en) * 2007-10-18 2007-11-28 Dallison Adam Supports
US7873421B2 (en) * 2007-10-23 2011-01-18 Manuel L Karell Nasal dilator adapted to provide electrical stimulation
ITMI20072156A1 (en) * 2007-11-13 2009-05-14 Biofarmitalia Spa NASAL PATCH
US8267962B2 (en) * 2007-12-03 2012-09-18 Stupak Howard D Device for repositioning cartilage and method of use
US20100042134A1 (en) * 2008-04-18 2010-02-18 Abraham Wien Nostril dilator
USD745147S1 (en) 2008-04-19 2015-12-08 Corbett Lair, Inc. Double band nasal dilator
USD746982S1 (en) 2008-04-19 2016-01-05 Corbett Lair Triple band nasal dilator
USD659245S1 (en) 2008-04-19 2012-05-08 Ierulli Joseph V Nasal dilator
EP2341875B1 (en) * 2008-09-30 2018-03-07 3M Innovative Properties Company Thin film nasal dilator with delivery system
US8246647B2 (en) * 2008-11-14 2012-08-21 Abraham Wien Nostril dilator
US20110000483A1 (en) * 2009-05-01 2011-01-06 Matthias Joseph A External nasal dilator
BR112013016440A2 (en) 2010-12-29 2016-10-04 3M Innovative Properties Co elastic strap, elastic substrate and method of attaching a strap
US9855360B2 (en) 2011-07-13 2018-01-02 Beekley Corporation Aromatic adhesive-backed tab and method of using same
US9364367B2 (en) 2011-11-01 2016-06-14 Corbett Lair, Inc. Overlapping resilient member structures in nasal dilator devices
US20130118488A1 (en) * 2011-11-14 2013-05-16 Barbara Ledogar Nasal Therapeutic System
USD725772S1 (en) 2013-05-24 2015-03-31 Corbett Lair Inc. Nasal dilator
US11134727B2 (en) 2012-07-10 2021-10-05 Jennifer V. Hearst Scented mask system
USD789531S1 (en) 2012-10-01 2017-06-13 Corbett-Lair Inc. Double band nasal dilator
USD706925S1 (en) 2013-02-15 2014-06-10 L. Perrigo Company Nasal dilator
USD722162S1 (en) 2013-02-15 2015-02-03 L. Perrigo Company Nasal dilator
USD706926S1 (en) 2013-02-15 2014-06-10 L. Perrigo Company Nasal dilator
USD722161S1 (en) 2013-02-15 2015-02-03 L. Perrigo Company Nasal dilator
USD725773S1 (en) 2013-05-24 2015-03-31 Corbett Lair Inc. Nasal dilator
USD743565S1 (en) 2013-06-17 2015-11-17 Ranir, Llc Nasal dilator
USD738496S1 (en) 2013-08-09 2015-09-08 Joseph Peck Nasal dilator
USD764662S1 (en) 2013-12-04 2016-08-23 Corbett Lair, Inc. Triple-band nasal dilator
USD764055S1 (en) 2013-12-04 2016-08-16 Corbett Lair, Inc. Double-band nasal dilator
EP2981231B1 (en) 2014-02-19 2020-03-25 Joseph V. Ierulli Nasal dilator with decorative design element
USD739015S1 (en) 2014-03-05 2015-09-15 Medline Industries, Inc. Nasal dilator
USD741998S1 (en) 2014-04-17 2015-10-27 Medline Industries, Inc. Nasal dilator
US20160015154A1 (en) 2014-07-18 2016-01-21 Matthew P. Veeder Use of adhesive patch and tension strap to reduce wrinkles in skin
USD889648S1 (en) 2015-02-17 2020-07-07 Corbett Lair, Inc. Nasal dilator
USD791312S1 (en) 2015-10-07 2017-07-04 Joseph Peck Nasal dilator device
USD894382S1 (en) 2015-12-21 2020-08-25 Corbett Lair, Inc. Nasal dilator
JP2019122503A (en) * 2018-01-14 2019-07-25 株式会社フィッツコーポレーション Nasal dilator
USD857889S1 (en) 2018-02-19 2019-08-27 Corbett Lair Inc. Nasal dilator with relief cuts
USD857888S1 (en) 2018-02-19 2019-08-27 Corbett Lair Inc. Nasal dilator with relief cuts
USD926612S1 (en) 2018-04-16 2021-08-03 Jesse Yepez-Patterson Diffuser ring
USD884167S1 (en) 2018-10-22 2020-05-12 Corbett Lair, Inc. External nasal dilator
US10893971B2 (en) 2018-10-22 2021-01-19 Corbett Lair, Inc. External nasal dilator with multiple discrete dilation points
US11344444B2 (en) 2019-04-06 2022-05-31 Corbett Lair Inc. Nasal dilators with improved breathability
USD903114S1 (en) 2019-04-06 2020-11-24 Corbett Lair, Inc. Nasal dilator
USD932620S1 (en) 2019-09-03 2021-10-05 Joseph V. Ierulli Nasal dilator with relief cuts
IT202000004954A1 (en) * 2020-03-09 2021-09-09 Giorgio Mardegan NASAL DILATOR DEVICE
JP2023075774A (en) * 2021-11-19 2023-05-31 小林製薬株式会社 Nose permeability improvement tool

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476091A (en) * 1991-06-10 1995-12-19 Creative Integration & Design, Inc. Dilator for anatomical outer wall tissues which is adhesively mounted
US5553605A (en) * 1995-08-31 1996-09-10 Muchin Jerome D Transparent external nasal dilator

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655129A (en) 1968-07-17 1972-04-11 Ppg Industries Inc Slow release films and methods of making same
US3567118A (en) 1968-09-05 1971-03-02 Nat Patent Dev Corp Entrapped essences in dry composite fiber base products giving a strong fragrance when wet in water
ES149951Y (en) * 1969-06-30 1970-06-01 Ramos Caballero DEVICE TO FACILITATE NASAL BREATHING.
US3965033A (en) 1970-07-27 1976-06-22 Fuji Photo Film Co., Ltd. Process for the production of oil-containing microcapsules
US3688985A (en) 1970-12-09 1972-09-05 Walter H Engel Plastic article of manufacture impregnated with volatile matter
US3909444A (en) 1971-08-05 1975-09-30 Ncr Co Microcapsule
US4016254A (en) 1972-05-19 1977-04-05 Beecham Group Limited Pharmaceutical formulations
US3846404A (en) 1973-05-23 1974-11-05 Moleculon Res Corp Process of preparing gelled cellulose triacetate products and the products produced thereby
US3985298A (en) 1973-05-23 1976-10-12 Moleculon Research Corporation Controlled release materials and method of use
GB1461445A (en) 1974-02-20 1977-01-13 Shell Int Research Slow-release composition
US3954963A (en) 1974-03-04 1976-05-04 Shell Oil Company Air reodorant compositions
US4067824A (en) 1976-09-27 1978-01-10 Anheuser-Busch, Incorporated Gelled perfume
US4128507A (en) 1977-02-28 1978-12-05 Polak's Frutal Works, Inc. Perfumed gels of hydroxypropyl cellulose
US4136250A (en) 1977-07-20 1979-01-23 Ciba-Geigy Corporation Polysiloxane hydrogels
US4267831A (en) 1979-09-24 1981-05-19 Aguilar Rogelio M Nasal air filter and medicament dispenser device
US4339356A (en) 1980-12-31 1982-07-13 The Procter & Gamble Company Heavily perfumed particles
US4356115A (en) 1981-04-27 1982-10-26 Ichiro Shibanai Fragrant synthetic resin product and method of producing the same
US4414977A (en) 1981-07-20 1983-11-15 Wisconsin Alumni Research Foundation Nasal dilator
US4492644A (en) 1982-04-15 1985-01-08 Soda Aoromatic Company, Limited Slowly releasing perfume compositions
US4597959A (en) 1982-04-30 1986-07-01 Arthur Barr Sustained release breath freshener, mouth and palate coolant wafer composition and method of use
US4523589A (en) 1983-06-29 1985-06-18 Krauser Robert S Method and apparatus for treating ailments
US4638043A (en) 1984-11-13 1987-01-20 Thermedics, Inc. Drug release system
US4880690A (en) 1984-11-13 1989-11-14 Thermedics, Inc. Perfume patch
JPS6393324A (en) 1986-10-09 1988-04-23 Daicel Chem Ind Ltd Deodorizing sheet
GB8627600D0 (en) * 1986-11-19 1986-12-17 Petruson B Nasal device
US4927631A (en) 1986-11-28 1990-05-22 Bates Harry L Decongestant preparation
AU105667S (en) 1987-11-19 1989-10-25 Pharmacure Health Care A B A nasal device
US4842761A (en) 1988-03-23 1989-06-27 International Flavors & Fragrances, Inc. Compositions and methods for controlled release of fragrance-bearing substances
US5102564A (en) 1989-04-12 1992-04-07 The Procter & Gamble Company Treatment of fabric with perfume/cyclodextrin complexes
US5223251A (en) 1989-05-30 1993-06-29 Purepac, Inc. Skin fragrance compositions
JP2834476B2 (en) * 1989-06-16 1998-12-09 エーザイ株式会社 Nasal inhalation patch
US5043161A (en) 1989-08-31 1991-08-27 Eurand America, Inc. Small, oily, free-flowing, silky-smooth, talc-like, dry microcapsules and aqueous formulations containing them
US4971798A (en) 1989-11-30 1990-11-20 Miles Inc. Hard confections containing hydrogenated isomaltulose and medicinally active ingredient
US5455043A (en) * 1990-06-13 1995-10-03 Fischel-Ghodsian; Fariba Device for controlled release of vaporous medications through nasal route
US5071704A (en) 1990-06-13 1991-12-10 Fischel Ghodsian Fariba Device for controlled release of vapors and scents
US5081104A (en) 1990-06-20 1992-01-14 Kurary Co., Ltd. Fragrance dispensing composition with controlled evaporation rate and air fragrance dispenser for dispensing same
US5175152A (en) 1990-09-28 1992-12-29 Singh Nikhilesh N Composition containing ephedrine base and alkyl salicylate for the delivery of ephedrine base in vapor form
GB9022147D0 (en) 1990-10-11 1990-11-21 Unilever Plc Perfumed underarm hygiene products
JPH04131624U (en) * 1991-05-24 1992-12-03 憲正 梅田 A patch that cures runny nose, stuffy nose, and rashes
IL101989A (en) * 1991-06-10 1996-10-31 Creative Integration & Design Nasal dilator
US5533499A (en) * 1991-06-10 1996-07-09 Creative Integration & Design, Inc. Nasal dilator
US5549103A (en) * 1991-06-10 1996-08-27 Creative Integration & Design, Inc. Nasal dilator having an adhesive void to allow relative movement
GB9120951D0 (en) 1991-10-02 1991-11-13 Unilever Plc Perfume particles
US5322689A (en) 1992-03-10 1994-06-21 The Procter & Gamble Company Topical aromatic releasing compositions
US5378468A (en) 1992-09-22 1995-01-03 The Mennen Company Composition containing body activated fragrance for contacting the skin and method of use
US5508259A (en) 1993-02-11 1996-04-16 Firmenich Sa Perfuming composition
JPH09500610A (en) 1993-04-30 1997-01-21 ザ、プロクター、エンド、ギャンブル、カンパニー Nasal fragrance releasing composition
US5391374A (en) 1993-05-10 1995-02-21 Minnesota Mining And Manufacturing Company Fragrance delivery compositions having low amounts of volatile organic compounds
JPH0748250A (en) 1993-06-04 1995-02-21 Sekisui Chem Co Ltd Tape for preventing sleepiness
US5380707A (en) 1993-08-13 1995-01-10 The Mennen Company Enhanced efficacy, long-lasting fragrance composition, and deodorant composition, for masking malodor, containing the fragrance composition
US5585343A (en) 1993-11-02 1996-12-17 Givaudan-Roure Corporation Low VOC perfume formulations
JPH07215847A (en) 1994-02-04 1995-08-15 Sekisui Chem Co Ltd Tape for sleepiness prevention
US5476019A (en) 1994-03-07 1995-12-19 Sram Corporation Rotatable handgrip actuating system
US5536263A (en) 1994-03-30 1996-07-16 Lectec Corporation Non-occulusive adhesive patch for applying medication to the skin
GB9422692D0 (en) 1994-04-22 1995-01-04 Williamson John B Disposable nasel band filter
AUPM784894A0 (en) 1994-09-02 1994-09-29 Murchie, Barry Joseph Baby's breathing aid
US5500154A (en) 1994-10-20 1996-03-19 The Procter & Gamble Company Detergent compositions containing enduring perfume
ATE180970T1 (en) 1994-12-19 1999-06-15 Procter & Gamble MEDICINATED TISSUE PAPER
US5569679A (en) 1994-12-30 1996-10-29 Russell A. Krueger Pharmaceuticals, Inc. Pharmacologic management of snoring
US5546929A (en) * 1995-07-07 1996-08-20 Muchin Jerome D Nasal dilator
US5725865A (en) 1995-08-29 1998-03-10 V. Mane Fils S.A. Coolant compositions
US5611333A (en) * 1995-12-15 1997-03-18 Creative Integration & Design, Inc. Dilator with peel force reducing structure
US5723420A (en) 1996-03-04 1998-03-03 The Procter & Gamble Company Personal cleansing bar compositions which contain a fragrance-releasing complex for improved fragrance delivery
US5669377A (en) 1996-07-05 1997-09-23 Fenn; Arthur C. Nasal band and method for improved breathing
IT1283778B1 (en) 1996-08-08 1998-04-30 Biofarm Srl NASAL DILATOR INCLUDING A LIMITED NUMBER OF COMPONENTS
JPH10120555A (en) 1996-10-19 1998-05-12 Nitto Denko Corp Medicine-containing adhesive sheet and production of medicine-containing adhesive sheet
US5890486A (en) 1996-12-20 1999-04-06 The Procter & Gamble Company Thermal nasal dilator and method of treatment for relief of nasal congestion and other symptoms associated with common cold and allergies
DE69728570T2 (en) 1996-12-20 2005-02-24 The Procter & Gamble Co., Cincinnati THERMAL NASAL DILATOR
US5706800A (en) 1997-01-29 1998-01-13 Cronk; Peter J. Medicated nasal dilator

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476091A (en) * 1991-06-10 1995-12-19 Creative Integration & Design, Inc. Dilator for anatomical outer wall tissues which is adhesively mounted
US5553605A (en) * 1995-08-31 1996-09-10 Muchin Jerome D Transparent external nasal dilator

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8852224B2 (en) 1997-01-29 2014-10-07 Peter J. Cronk Therapeutic delivery system
JP2011101809A (en) * 1998-06-18 2011-05-26 J Cronk Peter Nasal dilator
KR100341111B1 (en) * 1999-06-07 2002-06-20 홍중기 nasal dilator
US8834514B2 (en) 2006-08-30 2014-09-16 Xennovate Medical Llc Resilient band medical device

Also Published As

Publication number Publication date
JP2001511032A (en) 2001-08-07
JP2008188421A (en) 2008-08-21
BR9807099A (en) 2001-09-18
ZA98144B (en) 1999-05-03
DK1011552T3 (en) 2002-09-16
CN1249674A (en) 2000-04-05
DE69805814T2 (en) 2003-02-13
PT1011552E (en) 2002-11-29
US6276360B1 (en) 2001-08-21
CN1259893C (en) 2006-06-21
EP1011552B1 (en) 2002-06-05
JP4795370B2 (en) 2011-10-19
EP1011552A1 (en) 2000-06-28
AU6043698A (en) 1998-08-18
CA2278714A1 (en) 1998-07-30
JP4574753B2 (en) 2010-11-04
ATE218311T1 (en) 2002-06-15
CA2278714C (en) 2007-02-13
AU738977B2 (en) 2001-10-04
DE69805814D1 (en) 2002-07-11
EP1011552A4 (en) 2000-12-13
ES2178151T3 (en) 2002-12-16
US5706800A (en) 1998-01-13

Similar Documents

Publication Publication Date Title
CA2278714C (en) Externally mounted medicated nasal dilator
AU717899B2 (en) Nasal dilator with areas of adhesive engagement of varying strength
US6318362B1 (en) Nasal dilator
US5549103A (en) Nasal dilator having an adhesive void to allow relative movement
US5533503A (en) Nasal dilator
KR100345082B1 (en) A dilator for outer wall tissues of human anatomy
CA2689940C (en) Respiratory nasal filter
US6065470A (en) Nostril dilator
WO1994023675A1 (en) Nasal dilator
KR20030024875A (en) Curable adhesive splints and methods
CA2517948C (en) Nasal dilator
WO1999022678A1 (en) Improvements relating to adhesive devices such as strips, tapes, patches and the like, for application to the human body
EP0842646A1 (en) Improved nasal dilator
CA2217946A1 (en) Nostril dilator
WO1998006360A1 (en) Nasal dilator comprising a small number of components
US20240066088A1 (en) Infused nasal strip

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 98803071.3

Country of ref document: CN

AK Designated states

Kind code of ref document: A1

Designated state(s): AU BR CA CN JP

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

CFP Corrected version of a pamphlet front page

Free format text: REVISED ABSTRACT RECEIVED BY THE INTERNATIONAL BUREAU AFTER COMPLETION OF THE TECHNICAL PREPARATIONS FOR INTERNATIONAL PUBLICATION

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2278714

Country of ref document: CA

Ref document number: 2278714

Country of ref document: CA

Kind code of ref document: A

Ref document number: 1998 532220

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1998903748

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 60436/98

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 1998903748

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 60436/98

Country of ref document: AU

WWG Wipo information: grant in national office

Ref document number: 1998903748

Country of ref document: EP