WO1998029037A1 - Biopsy needle - Google Patents
Biopsy needle Download PDFInfo
- Publication number
- WO1998029037A1 WO1998029037A1 PCT/GB1997/003494 GB9703494W WO9829037A1 WO 1998029037 A1 WO1998029037 A1 WO 1998029037A1 GB 9703494 W GB9703494 W GB 9703494W WO 9829037 A1 WO9829037 A1 WO 9829037A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- biopsy needle
- needle according
- biopsy
- length
- endometrial
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
- A61B10/0275—Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
Definitions
- tissue samples - biopsy material provided by curettage is viewed by pathologists as being ideal (Dallenbach-Hellweg, G., 1987, Histopathology of the endometrium, Springer- Verlag, Berlin Heidelberg New York London Paris Tokyo, Fourth Edition), but requires a general anaesthetic.
- office biopsy techniques were introduced (i.e. techniques which do not require an operating theatre or general anaesthetic) (Novak, E., 1935, A suction curet apparatus for endometrial biopsy, JAMA, 104: 1497; Randall, L.M., 1935, Proc. Mayo Clin., 10: 143) and more recent modifications, such as vabra curette and pipelle samples have taken advantage of technological advances by using thinner disposable cannulae.
- the tissues obtained primarily represent the superficial functionalis of the endometrium, and not the stratum compacta or the basalis - this is particularly the case with suction curette. Deeper samples may be obtained by the use of a sharp curette under general anaesthetic, but only at the increased risk of uterine perforation.
- Biopsies obtained cannot be oriented and examined vertically to include the whole thickness.
- MJZ my ometrial junction zone
- Gynaecol., 168: 55-59 have investigated the use of pipelle endometrial samplers and the vabra aspirator. They found that the former sampled only 4.2% ⁇ 0.92% of the total endometrial surface, compared to vabra that was successful in sampling 41.6% ⁇ 5.7% of the endometrium.
- a safe, easy-to-use, reliable and accurate biopsy needle which overcomes the aforementioned deficiencies of the prior art, comprising along its length an angled tip and a first shank mounted on a relatively thin rod-like extensor, in turn mounted on a second shank section.
- the needle may have a total length of at least 40 cm. It may, for example, have a total length of about 48 cm.
- the angled tip and first shank section may have a combined length of about 5 cm.
- the rod-like extensor may have a length of about 18 cm.
- the second shank section may have a length of at least 15 cm. It may, for example, have a length of about 25 cm.
- the rod-like extensor may have an arc of less than 180° about the centre axis of the needle. It may have an arc of less than 90°. It may have an arc of about 60°.
- the biopsy needle may have a diameter of about 16G (1.6mm).
- the biopsy needle may be used in endometrial biopsies. It may allow the collection of an endometrial sample having all layers of the endometrium and the inner myometrium. It may allow the collection of an endometrial sample including the MJZ.
- Also provided according to the present invention is the use of a biopsy needle according to the present invention in endometrial biopsy.
- Also provided according to the present invention is a method of biopsy, for example endometrial biopsy, comprising the useof a biopsy needle according to the present invention.
- the method may comprise the steps of performing a biopsy as described below.
- Figure 1 A shows a side view of a biopsy needle according to the present invention
- Figure IB shows a side view of a conventional biopsy needle.
- Figure 1 illustrates a biopsy needle 11 comprising along its length an angled tip 12 and a first shank 13 mounted on a relatively thin rod-like extensor 14, in turn mounted on a second shank section 15.
- the needle 11 has a total length of about 48cm.
- the angled tip 12 and first shank section 13 have a combined length of about 5cm.
- the rod-like extensor 14 has a length of about 18cm and an arc of about 60°.
- the second shank section 15 has a length of about 25cm.
- the biopsy needle 11 of the present invention ( Figure 1), having a diameter of 16G (1.6mm) and a length of about 48cm, driven by a high speed Core Cut (not shown) (Biomed-Instrumente Kunststoff GmbH, Am Brand 1, D-8087, T ⁇ rkenfeld, Germany) was used according to standard biopsy procedure and the Core Cut manufacturers instructions. The use of the high speed Core Cut minimises tissue displacement and trauma. The Core Cut was adjusted to penetrate to a depth of 16 mm.
- the core cut is a two-stage biopsy gun.
- the first spring action thrusts the inner trocar (i.e. the biopsy needle 11) forwards, followed almost instantaneously by a similar thrust of the outer cutting cannula.
- FIG 2 illustrates the contrasting conventional biopsy needle 21 having an angled tip 22 attached to a shank, section 23. It has a total length of approximately 34cm and is of a similar, diameter to that of the biopsy needle 11.
- the biopsy needle 11 was used in outpatient procedure under local anaesthetic (Downes, E. and Al-Azzawi, F., 1993, Eur. J. Obstet. Gynecol. Reprod. Biol., 48: 37-41), using CO 2 distension medium and the Wolf luminal 2.7 mm (8Fr), 25 ° hysteroscope with the 15 Fr rigid sheath. This instrument allows an operative channel of 2.3 mm (7 Fr).
- the width of the sample was about 1 mm, providing a core from which up to 30 histological sections could be obtained.
- Microscopic examination revealed all layers of the endometrium and the inner myometrium in every case. Histological diagnosis was possible in all cases and corresponded to that obtained by pipelle in the same patient. Diagnosis of atrophic endometrium was obtained in 7 cases, 8 were proliferative, and 25 had secretory endometrium. Adenomyosis was diagnosed in two cases. Discussion:
- this new biopsy needle overcomes all deficiencies associated with previous methods and apparatus for endometrial biopsy.
- the use of the core cut reduced the number of passes required and simplified the procedure.
- the high speed of the core cut also ensured that the procedure was well tolerated, and this was comparable to the high tolerance to a similar device used for testicular biopsy (Morey, A.F. et al, 1994, Brit. J. Urol., 74: 366-369).
- HNB could be targeted to specific regions of interest under vision, and a full thickness including the basalis could be obtained in all cases.
- the biopsies could furthermore be orientated during processing to allow examination of the deeper layers.
- Biopsies were obtained from the myometrial junctional zone (MJZ) in all cases, and this work presents new prospects in the study of its structural and functional correlates.
- the finding of adenomyosis in two specimens is interesting.
- Laparoscopic myometrial biopsy has been reported to have a 8% to a 18.7% sensitivity for this diagnosis (Popp, L.W. et al., ⁇ 99?>, Am. J. Obstet. Gynecol., 169: 546- 549), but we are able to target the uterine fundus, through a transcavitary approach we expect a higher success rate.
- the present invention is an innovative, safe and well tolerated device for biopsies and in particular endometrial sampling, that is useful for both routine histological diagnosis and for endometrial research. It provides directed endometrial/junctional zone myometrial diagnosis.
- the area of interest can be biopsied under hysteroscopic guidance in an outpatient set up.
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9802258A GB2323789A (en) | 1997-01-04 | 1997-12-18 | Biopsy needle |
AU53297/98A AU5329798A (en) | 1997-01-04 | 1997-12-18 | Biopsy needle |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9700092.1A GB9700092D0 (en) | 1997-01-04 | 1997-01-04 | Biopsy needle |
GB9700092.1 | 1997-01-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998029037A1 true WO1998029037A1 (en) | 1998-07-09 |
Family
ID=10805536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1997/003494 WO1998029037A1 (en) | 1997-01-04 | 1997-12-18 | Biopsy needle |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU5329798A (en) |
GB (2) | GB9700092D0 (en) |
WO (1) | WO1998029037A1 (en) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4735215A (en) * | 1987-01-05 | 1988-04-05 | Goto David S | Soft tissue biopsy instrument |
US4917100A (en) * | 1989-05-08 | 1990-04-17 | Nottke James E | Biopsy needle for use with spring-operated actuating mechanism |
US5069224A (en) * | 1989-02-24 | 1991-12-03 | Zinnanti Jr Anthony | Endometrial aspirator |
GB2256369A (en) * | 1991-06-04 | 1992-12-09 | Chiou Rei Kwen | Negative pressure biopsy needle |
US5449001A (en) * | 1994-04-14 | 1995-09-12 | Terwilliger; Richard A. | Biopsy needle |
US5564436A (en) * | 1995-09-21 | 1996-10-15 | Hakky; Said I. | Automatic rotating cassette multiple biopsy device |
-
1997
- 1997-01-04 GB GBGB9700092.1A patent/GB9700092D0/en active Pending
- 1997-12-18 GB GB9802258A patent/GB2323789A/en not_active Withdrawn
- 1997-12-18 WO PCT/GB1997/003494 patent/WO1998029037A1/en active Application Filing
- 1997-12-18 AU AU53297/98A patent/AU5329798A/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4735215A (en) * | 1987-01-05 | 1988-04-05 | Goto David S | Soft tissue biopsy instrument |
US5069224A (en) * | 1989-02-24 | 1991-12-03 | Zinnanti Jr Anthony | Endometrial aspirator |
US4917100A (en) * | 1989-05-08 | 1990-04-17 | Nottke James E | Biopsy needle for use with spring-operated actuating mechanism |
GB2256369A (en) * | 1991-06-04 | 1992-12-09 | Chiou Rei Kwen | Negative pressure biopsy needle |
US5449001A (en) * | 1994-04-14 | 1995-09-12 | Terwilliger; Richard A. | Biopsy needle |
US5564436A (en) * | 1995-09-21 | 1996-10-15 | Hakky; Said I. | Automatic rotating cassette multiple biopsy device |
Also Published As
Publication number | Publication date |
---|---|
AU5329798A (en) | 1998-07-31 |
GB2323789A (en) | 1998-10-07 |
GB9802258D0 (en) | 1998-04-01 |
GB9700092D0 (en) | 1997-02-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6280398B1 (en) | Methods and devices for collection of soft tissue | |
US6050955A (en) | Biopsy apparatus and method | |
US4781202A (en) | Biopsy cannula | |
US6019733A (en) | Biopsy apparatus and method | |
US6176834B1 (en) | Minimally invasive biopsy device | |
US5913857A (en) | Methods and devices for collection of soft tissue | |
US5823970A (en) | Biopsy needle set | |
JP2004523273A (en) | Biopsy device and method of use | |
Gungorduk et al. | Comparison of the histopathological diagnoses of preoperative dilatation and curettage and Pipelle biopsy | |
US6981949B2 (en) | Perimeter cut biopsy probe | |
Stamatellos et al. | The role of hysteroscopy in the current management of the cervical polyps | |
EP0919190A2 (en) | Biopsy instrument with continuous tissue receiving chamber | |
Davies et al. | Preoperative diagnosis in carcinoma of the breast | |
JPH11262490A (en) | Biopsy assembly | |
WO1998029037A1 (en) | Biopsy needle | |
EP0919192A2 (en) | Biopsy instrument including tip for tissue dilation | |
Cohen et al. | SCREENING FOR ENDOMETRICAL CANCER | |
Crow et al. | An assessment of the Mi-Mark endoemtrial sampling technique. | |
Krampl et al. | How representative are pipelle endometrial biopsies? A retrospective analysis of 324 biopsies followed by transcervical resection of the endometrium or hysterectomy | |
Al-Azzawi et al. | The Leicester Endometrial Needle Sampler: a novel device for endometrial and myometrial junctional zone biopsy | |
Samejima et al. | New electric drill biopsy apparatus for breast tumors | |
WO2002062232A1 (en) | Biopsy apparatus and method | |
WO2005027748A1 (en) | Tissue drilling tool and biopsy system | |
Abdel-Mageed et al. | Emerging Overview about Diagnosis of Dysfunctional Uterine Bleeding | |
Ngan et al. | Diagnosis of Endometrial Carcinoma by Histopathological Examination of the Endometrial Aspirate by the Curity‐Isaacs Sampler |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ENP | Entry into the national phase |
Ref country code: GB Ref document number: 9802258 Kind code of ref document: A Format of ref document f/p: F |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
NENP | Non-entry into the national phase |
Ref country code: JP Ref document number: 1998529737 Format of ref document f/p: F |
|
122 | Ep: pct application non-entry in european phase |