WO1998026763A1 - Active substance carrier for releasing apomorphine into the buccal cavity - Google Patents
Active substance carrier for releasing apomorphine into the buccal cavity Download PDFInfo
- Publication number
- WO1998026763A1 WO1998026763A1 PCT/EP1997/006529 EP9706529W WO9826763A1 WO 1998026763 A1 WO1998026763 A1 WO 1998026763A1 EP 9706529 W EP9706529 W EP 9706529W WO 9826763 A1 WO9826763 A1 WO 9826763A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- apomorphine
- pharmaceutical preparation
- preparation according
- active ingredient
- active substance
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97952795A EP0959875A1 (en) | 1996-12-16 | 1997-11-21 | Active substance carrier for releasing apomorphine into the buccal cavity |
JP52593498A JP2001506612A (en) | 1996-12-16 | 1997-11-21 | Active substance carrier for release of apomorphine into the oral cavity |
AU56547/98A AU746373B2 (en) | 1996-12-16 | 1997-11-21 | Active substance carrier for releasing apomorphine into the buccal cavity |
CA002274893A CA2274893A1 (en) | 1996-12-16 | 1997-11-21 | Active substance carrier for releasing apomorphine into the buccal cavity |
NO992944A NO992944D0 (en) | 1996-12-16 | 1999-06-16 | Active ingredient for the delivery of apomorphine in the oral cavity |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19652268.4 | 1996-12-16 | ||
DE19652268A DE19652268C2 (en) | 1996-12-16 | 1996-12-16 | Medicinal preparation for the release of apomorphine in the oral cavity |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998026763A1 true WO1998026763A1 (en) | 1998-06-25 |
Family
ID=7814859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1997/006529 WO1998026763A1 (en) | 1996-12-16 | 1997-11-21 | Active substance carrier for releasing apomorphine into the buccal cavity |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0959875A1 (en) |
JP (1) | JP2001506612A (en) |
KR (1) | KR20000057627A (en) |
AU (1) | AU746373B2 (en) |
CA (1) | CA2274893A1 (en) |
DE (1) | DE19652268C2 (en) |
NO (1) | NO992944D0 (en) |
WO (1) | WO1998026763A1 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291471B1 (en) | 1998-12-17 | 2001-09-18 | Abb Holdings, Inc. | Use of apomorphine for the treatment of organic erectile dysfunction in males |
US6596298B2 (en) | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
US7067116B1 (en) | 2000-03-23 | 2006-06-27 | Warner-Lambert Company Llc | Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1 |
US7314716B2 (en) | 1999-11-19 | 2008-01-01 | Mount Sinai School Of Medicine | Gustducin γ subunit materials and methods |
USRE40594E1 (en) | 1998-12-23 | 2008-12-02 | Mount Sinai School Of Medicine Of New York University | Inhibitors of the bitter taste response |
WO2010144817A1 (en) | 2009-06-12 | 2010-12-16 | Adagio Pharmaceuticals Ltd. | Sublingual apomorphine |
US7910132B2 (en) | 1998-09-24 | 2011-03-22 | Orexo Ab | Pharmaceutical composition for the treatment of acute disorders |
WO2012083269A1 (en) | 2010-12-16 | 2012-06-21 | Cynapsus Therapeutics, Inc. | Sublingual films |
US8481071B2 (en) | 2001-05-01 | 2013-07-09 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
US8481059B2 (en) | 2001-05-01 | 2013-07-09 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences | Hydrogel compositions |
US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US8617647B2 (en) | 2001-05-01 | 2013-12-31 | A.V. Topchiev Institutes of Petrochemical Synthesis, Russian Academy of Sciences | Water-absorbent adhesive compositions and associated methods of manufacture and use |
US8658201B2 (en) * | 2004-01-30 | 2014-02-25 | Corium International, Inc. | Rapidly dissolving film for delivery of an active agent |
US8784879B2 (en) | 2009-01-14 | 2014-07-22 | Corium International, Inc. | Transdermal administration of tamsulosin |
US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
USRE45666E1 (en) | 2000-07-07 | 2015-09-08 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
US10449146B2 (en) | 2015-04-21 | 2019-10-22 | Sunovion Pharmaceuticals Inc. | Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10252726B4 (en) * | 2002-11-13 | 2008-05-08 | Lts Lohmann Therapie-Systeme Ag | Multilayer transmucosal therapeutic system |
AU2003277788A1 (en) * | 2002-11-14 | 2004-06-03 | Givaudan Sa | Edible film containing food acid |
KR100945741B1 (en) * | 2003-01-16 | 2010-03-05 | 부광약품 주식회사 | Oral spray preparation of apomorphine hydrochloride |
US20050281757A1 (en) * | 2004-06-17 | 2005-12-22 | Sayed Ibrahim | Oral care film |
US10806703B2 (en) | 2012-01-20 | 2020-10-20 | Lts Lohmann Therapie-System Ag | Transmucosal administration system for a pharmaceutical drug |
KR20160108828A (en) * | 2013-11-11 | 2016-09-20 | 임팩스 라보라토리즈, 인코포레이티드 | Rapidly disintegrating formulations and methods of use |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3972995A (en) * | 1975-04-14 | 1976-08-03 | American Home Products Corporation | Dosage form |
WO1995028930A1 (en) * | 1994-04-22 | 1995-11-02 | Pentech Pharmaceuticals, Inc. | Dosage forms and method for ameliorating male erectile dysfunction |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2746414A1 (en) * | 1977-10-15 | 1979-04-26 | Gerlach Eduard Chem Fab | Foil-like tape for dispensing measured amts. of substance - consisting of the substance, binding agent and adjuvants, tape length being proportional to weight of substance |
FR2732896B1 (en) * | 1995-04-11 | 1997-06-13 | Prographarm Lab | TRANSDERMAL PHARMACEUTICAL FORM FOR PERCUTANEOUS ADMINISTRATION OF APOMORPHINE |
-
1996
- 1996-12-16 DE DE19652268A patent/DE19652268C2/en not_active Expired - Fee Related
-
1997
- 1997-11-21 JP JP52593498A patent/JP2001506612A/en active Pending
- 1997-11-21 WO PCT/EP1997/006529 patent/WO1998026763A1/en not_active Application Discontinuation
- 1997-11-21 CA CA002274893A patent/CA2274893A1/en not_active Abandoned
- 1997-11-21 AU AU56547/98A patent/AU746373B2/en not_active Ceased
- 1997-11-21 EP EP97952795A patent/EP0959875A1/en not_active Withdrawn
- 1997-11-21 KR KR1019990705422A patent/KR20000057627A/en not_active Application Discontinuation
-
1999
- 1999-06-16 NO NO992944A patent/NO992944D0/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3972995A (en) * | 1975-04-14 | 1976-08-03 | American Home Products Corporation | Dosage form |
WO1995028930A1 (en) * | 1994-04-22 | 1995-11-02 | Pentech Pharmaceuticals, Inc. | Dosage forms and method for ameliorating male erectile dysfunction |
Cited By (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8454996B2 (en) | 1998-09-24 | 2013-06-04 | Orexo Ab | Pharmaceutical composition for the treatment of acute disorders |
US8512747B2 (en) | 1998-09-24 | 2013-08-20 | Orexo Ab | Pharmaceutical composition for the treatment of acute disorders |
US7910132B2 (en) | 1998-09-24 | 2011-03-22 | Orexo Ab | Pharmaceutical composition for the treatment of acute disorders |
EP1676557A2 (en) | 1998-09-25 | 2006-07-05 | Warner-Lambert Company LLC | Fast dissolving orally consumable films |
US7025983B2 (en) | 1998-09-25 | 2006-04-11 | Warner-Lambert Company Llc | Fast dissolving orally consumable films |
US7491406B2 (en) | 1998-09-25 | 2009-02-17 | Mcneil-Ppc, Inc. | Fast dissolving orally consumable films |
US6923981B2 (en) | 1998-09-25 | 2005-08-02 | Warner-Lambert Company | Fast dissolving orally consumable films |
US6596298B2 (en) | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
US6291471B1 (en) | 1998-12-17 | 2001-09-18 | Abb Holdings, Inc. | Use of apomorphine for the treatment of organic erectile dysfunction in males |
USRE40594E1 (en) | 1998-12-23 | 2008-12-02 | Mount Sinai School Of Medicine Of New York University | Inhibitors of the bitter taste response |
US7314716B2 (en) | 1999-11-19 | 2008-01-01 | Mount Sinai School Of Medicine | Gustducin γ subunit materials and methods |
US7067116B1 (en) | 2000-03-23 | 2006-06-27 | Warner-Lambert Company Llc | Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1 |
EP1674078A2 (en) | 2000-03-23 | 2006-06-28 | Warner-Lambert Company LLC | Fast dissolving orally consumable filsm containing an ion exchange resin as a taste masking agent |
US7648712B2 (en) | 2000-03-23 | 2010-01-19 | Mcneil-Ppc, Inc. | Fast dissolving orally consumable films containing a taste masking agent |
USRE45666E1 (en) | 2000-07-07 | 2015-09-08 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
US9687428B2 (en) | 2001-05-01 | 2017-06-27 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US9532935B2 (en) | 2001-05-01 | 2017-01-03 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US10179096B2 (en) | 2001-05-01 | 2019-01-15 | Corium International, Inc. | Hydrogel compositions for tooth whitening |
US8481071B2 (en) | 2001-05-01 | 2013-07-09 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
US8481059B2 (en) | 2001-05-01 | 2013-07-09 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences | Hydrogel compositions |
US9127140B2 (en) | 2001-05-01 | 2015-09-08 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Water-absorbent adhesive compositions and associated methods of manufacture and use |
US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US8617647B2 (en) | 2001-05-01 | 2013-12-31 | A.V. Topchiev Institutes of Petrochemical Synthesis, Russian Academy of Sciences | Water-absorbent adhesive compositions and associated methods of manufacture and use |
US10869947B2 (en) | 2001-05-01 | 2020-12-22 | Corium, Inc. | Hydrogel compositions |
US8741331B2 (en) | 2001-05-01 | 2014-06-03 | A. V. Topchiev Institute of Petrochemicals Synthesis, Russian Academy of Sciences | Hydrogel compositions with an erodible backing member |
US9259504B2 (en) | 2001-05-01 | 2016-02-16 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Non-electrically conductive hydrogel composition |
US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US10835454B2 (en) | 2001-05-01 | 2020-11-17 | Corium, Inc. | Hydrogel compositions with an erodible backing member |
US9089481B2 (en) | 2001-05-01 | 2015-07-28 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US9084723B2 (en) | 2001-05-01 | 2015-07-21 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions with an erodible backing member |
US9144552B2 (en) | 2004-01-30 | 2015-09-29 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences | Rapidly dissolving film for delivery of an active agent |
US8658201B2 (en) * | 2004-01-30 | 2014-02-25 | Corium International, Inc. | Rapidly dissolving film for delivery of an active agent |
US9610253B2 (en) | 2009-01-14 | 2017-04-04 | Corium International, Inc. | Transdermal administration of tamsulosin |
US8784879B2 (en) | 2009-01-14 | 2014-07-22 | Corium International, Inc. | Transdermal administration of tamsulosin |
US10238612B2 (en) | 2009-01-14 | 2019-03-26 | Corium International, Inc. | Transdermal administration of tamsulosin |
CN102480958B (en) * | 2009-06-12 | 2015-08-19 | Cynapsus疗法有限公司 | sublingual apomorphine |
EP2442650A4 (en) * | 2009-06-12 | 2012-11-14 | Adagio Pharmaceuticals Inc | Sublingual apomorphine |
EP2442650B1 (en) | 2009-06-12 | 2015-08-26 | Cynapsus Therapeutics Inc. | Sublingual apomorphine |
WO2010144817A1 (en) | 2009-06-12 | 2010-12-16 | Adagio Pharmaceuticals Ltd. | Sublingual apomorphine |
US9326981B2 (en) | 2009-06-12 | 2016-05-03 | Cynapsus Therapeutics, Inc. | Sublingual apomorphine |
AU2019200308B2 (en) * | 2009-06-12 | 2020-11-26 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
EP2442650A1 (en) * | 2009-06-12 | 2012-04-25 | Adagio Pharmaceuticals Inc. | Sublingual apomorphine |
AU2010259971B2 (en) * | 2009-06-12 | 2016-10-27 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
US9044475B2 (en) | 2009-06-12 | 2015-06-02 | Cynapsus Therapeutics, Inc. | Sublingual apomorphine |
AU2010259971C1 (en) * | 2009-06-12 | 2017-02-16 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
US10420763B2 (en) | 2009-06-12 | 2019-09-24 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
US9669020B2 (en) | 2009-06-12 | 2017-06-06 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
US9669021B2 (en) | 2009-06-12 | 2017-06-06 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
US9669019B2 (en) | 2009-06-12 | 2017-06-06 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
US9669018B2 (en) | 2009-06-12 | 2017-06-06 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
EP2952191A1 (en) * | 2009-06-12 | 2015-12-09 | Cynapsus Therapeutics Inc. | Sublingual apomorphine |
AU2017200329B2 (en) * | 2009-06-12 | 2018-11-08 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
CN102480958A (en) * | 2009-06-12 | 2012-05-30 | Adagio制药有限公司 | Sublingual apomorphine |
EP3434270A1 (en) * | 2009-06-12 | 2019-01-30 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
WO2012083269A1 (en) | 2010-12-16 | 2012-06-21 | Cynapsus Therapeutics, Inc. | Sublingual films |
US10285953B2 (en) | 2010-12-16 | 2019-05-14 | Sunovion Pharmaceuticals Inc. | Sublingual films |
US8846074B2 (en) | 2010-12-16 | 2014-09-30 | Cynapsus Therapeutics, Inc. | Sublingual films |
EP3735988A1 (en) * | 2010-12-16 | 2020-11-11 | Sunovion Pharmaceuticals Inc. | Sublingual films |
US9427412B2 (en) | 2010-12-16 | 2016-08-30 | Cynapsus Therapeutics, Inc. | Sublingual films |
EP2651357A4 (en) * | 2010-12-16 | 2016-07-20 | Cynapsus Therapeutics Inc | Sublingual films |
US9283219B2 (en) | 2010-12-16 | 2016-03-15 | Cynapsus Therapeutics, Inc. | Sublingual films |
US11419769B2 (en) | 2010-12-16 | 2022-08-23 | Sunovion Pharmaceuticals Inc. | Sublingual films |
US10449146B2 (en) | 2015-04-21 | 2019-10-22 | Sunovion Pharmaceuticals Inc. | Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa |
US10959943B2 (en) | 2015-04-21 | 2021-03-30 | Sunovion Pharmaceuticals Inc. | Methods of treating Parkinson's disease by administration of apomorphine to an oral mucosa |
Also Published As
Publication number | Publication date |
---|---|
AU5654798A (en) | 1998-07-15 |
AU746373B2 (en) | 2002-04-18 |
EP0959875A1 (en) | 1999-12-01 |
NO992944L (en) | 1999-06-16 |
DE19652268A1 (en) | 1998-06-18 |
KR20000057627A (en) | 2000-09-25 |
CA2274893A1 (en) | 1998-06-25 |
DE19652268C2 (en) | 2000-06-29 |
JP2001506612A (en) | 2001-05-22 |
NO992944D0 (en) | 1999-06-16 |
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