WO1998025534A1 - Vorrichtung zur verbindung eines längsträgers mit einer pedikelschraube - Google Patents
Vorrichtung zur verbindung eines längsträgers mit einer pedikelschraube Download PDFInfo
- Publication number
- WO1998025534A1 WO1998025534A1 PCT/CH1996/000437 CH9600437W WO9825534A1 WO 1998025534 A1 WO1998025534 A1 WO 1998025534A1 CH 9600437 W CH9600437 W CH 9600437W WO 9825534 A1 WO9825534 A1 WO 9825534A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- collet
- head
- channel
- pedicle screw
- screw
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7035—Screws or hooks, wherein a rod-clamping part and a bone-anchoring part can pivot relative to each other
- A61B17/7037—Screws or hooks, wherein a rod-clamping part and a bone-anchoring part can pivot relative to each other wherein pivoting is blocked when the rod is clamped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7041—Screws or hooks combined with longitudinal elements which do not contact vertebrae with single longitudinal rod offset laterally from single row of screws or hooks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7032—Screws or hooks with U-shaped head or back through which longitudinal rods pass
- A61B17/7034—Screws or hooks with U-shaped head or back through which longitudinal rods pass characterised by a lateral opening
Definitions
- the invention relates to a device according to the preamble of claim 1.
- pedicle screws for spinal fixation are already known from the prior art, which have the advantage that the individual pedicle screws can be implanted independently of the longitudinal support.
- the side member is subsequently inserted and fixed either laterally or from above into the pedicle screw.
- Such a pedicle screw is known for example from EP-B 0 330 881 SHERMAN.
- the disadvantage of the known pedicle screws consists in the, in some cases, relatively complicated locking mechanisms in order to fix the elongated member inserted into the openly formed pedicle screw head.
- the head of the screw can only be aligned to the length of the length bar, which means that the length bar has to be bent to an end.
- an anchoring element according to the preamble of claim 1 is known, in which the kuqeliqe head of a pedicle screw can be snapped into a compressible pressure element and thereby enables a certain angulation of the pedicle screw.
- Tensioning of the pressure element in the receiving head takes place due to a mechanism already disclosed in PCT / CH92 / 00125, in that the frustoconical pressure element is moved in a complementary conical bore towards its tapering end and is thereby jammed.
- the spherical head of the bone screw is also fixed in any angular position.
- the disadvantages of this known device are the following: a) the design of the hollow cylindrical pressure element receiving the ball head, which only has two longitudinal slots which are only open at the bottom and extend to the same side (in the direction of the bone screw). As a result, the spherical head of the bone screw is not homogeneously enclosed by the lamellae of the slotted pressure element during clamping. This inhomogeneous enclosing of the ball head causes a reduced clamping force; b) the bone screw must be preassembled by inserting it together with the pressure element from above through the exception for the tensioning element and securing it against rotation, ie the bone screw cannot be screwed in independently of the receiving head.
- the recording head enables no placement after implantation of the bone screw.
- Another disadvantage is that it is not possible to change the autopilot head in situ depending on the situation. c) the low stability of the legs, which only allows a tension belt fixation; d) the long support of the device and the spherical head of the bone screw are simultaneously fixed with the clamping means.
- the invention seeks to remedy this.
- the aim of the invention is to provide a device for connecting a long support to a pedicle screw with the following properties: easy to use
- Screwing in the screw part of the device even without the receiving head - Possible subsequent click on the recording head;
- the upward-open pick-up head makes it easier to insert the side member, while a side opening enables side corrections.
- separate fixation of the longitudinal beam and the spherical head of the bone screw is possible.
- the invention achieves the stated object with a device which has the features of claim 1.
- the device according to the invention consists of a receiving head receiving the longitudinal beam, into which a pedicle screw, preferably having a spherical head, can subsequently be clicked in and fixed.
- the desired number and variant of the recording head can simply be clipped onto the pedicle screws with ball head already implanted in the vertebral bodies, so that a primary connection is established between the long support and the pedicle screw.
- the adjusting screw which serves as a clamping means, presses on the long support inserted into the device, which prints on an alternately slotted hollow cone stub, which in turn is pressed together due to the conical design of the inner bore of the head of the fixation device and thereby clamps the preferably spherical head of the pedicle screw.
- a stiff intermediate element is advantageously inserted between the long beam and the hollow truncated cone.
- the device according to the invention thus offers the advantage over known devices that the pedicle screws can not only be fixed exactly perpendicular to the long support, but also allow a deviation of up to ⁇ 25 ° and, owing to the distance between the center of rotation of the pick-up head and the axis of the long support ⁇ e after it Thicknesses between 4 and 10 mm can to a certain extent also compensate for lateral deviations between the long support and the pedicle screw. This is particularly important if the long beam has been inaccurately anqeboqen, which leads to great difficulties in assembly with conventional systems.
- Another advantage of the device according to the invention is that after the rigid intermediate element and the Clamping means, or design of the long support device and the preferably spherical head of the bone screw can be blocked separately.
- a preferred development of the device according to the invention consists in that the preferably spherical head of the pedicle screw is preferably provided with a structuring in the form of quemlins or transverse ribs in order to achieve better fixation (tensioning against the collet).
- the heat stability can be increased further by the screw head being made of a relatively hard material (e.g. titanium-aluminum-nlob alloy) and the alternately slotted hollow truncated cone made of a relatively soft material (e.g. titanium in a soft state).
- a relatively hard material e.g. titanium-aluminum-nlob alloy
- the alternately slotted hollow truncated cone made of a relatively soft material (e.g. titanium in a soft state).
- Another possibility to increase the heat stability is to shape the preferably spherical head of the pedicle screw and / or the complementary cavity in the truncated cone with a three-dimensional structure, e.g. to roughen in the form of grooves.
- the structuring on the screw head made of relatively hard material is printed into the relatively soft material of the hollow truncated cone.
- they are preferably provided with a hexagon socket in the ball coupling. If the clickable head is still pierced, either the pedicle screw or the entire device can be screwed in. The latter has the particular advantage that at any time the device can be turned in or turned back in order to achieve a high level.
- the kick mechanism used in accordance with the invention has the further advantage over other known kick mechanisms, e.g. according to US-A-5 549 608 that after the autoclick, an accidental solution of the connection produced is no longer possible due to the manipulations to be carried out. If the connection created has to be intentionally released again, a special instrument is required.
- Figure 1 is a perspective exploded view of the device according to the invention with an open top head together with an elongated support, a pedicle screw with Kugeikopt and a clamping means.
- Figure 2 shows a Lanqssehmtt through the ertmdungsgemasse device of Figure 1 along ⁇ er Zentraiaense.
- Fig. 3 is a perspective view of a modified inventions according to the invention with a closed channel for receiving a long beam, and a clamping device.
- FIG. 4 shows a perspective view of a modified device according to the invention with a channel which is laterally (instead of close to the top) for receiving an elongated support and a tensioning means;
- FIG. 5 shows a perspective view of a modified device according to the invention with a laterally open channel for receiving an elongated support and an additional sleeve and nut for fixing the elongated support;
- F g. o a perspective view of a modified device according to the invention, in which the long beam is spaced from the central axis;
- FIG. 7 shows a longitudinal section through a modified device according to the invention, with which the long support and the preferably spherical copy of the bone ski can be blocked separately; 8 shows a longitudinal section through a modified device according to the invention with properties if F g. 7 ollenbart, with the difference that the set screws for the fixation of the long support and the preferably spherical head of the bone screw are mechanically decoupled; and
- Fig. 9 shows a longitudinal section through a modified device according to the invention corresponding to Fig. 8 m t uem advantage, so that the long beam can be seen from above.
- the device shown in FIGS. 1 and 2 essentially consists of a take-up head 3 with the central axis 4 and a ⁇ ocn-like, upwardly open channel 5 for receiving the elongated beam 1, which is transverse to the central axis 4, and a downwardly conical one downwardly extending conical frustum-shaped cavity 6 with the central axis 4, in a soft, coaxial screw-in, a honikegististpttor collet 7 with alternating slots 8 is accommodated, which is designed to receive the head 9 of a pedicle screw 2.
- the cone-shaped cavity 6 expediently has a half cone angle ⁇ / 2 of approximately 6 °.
- the hollow truncated cone-shaped collet 7 with alternating slots 8 has a corresponding half cone angle ⁇ / 2 of approximately 6 °.
- the collet 7 can thanks to their slots 8, stretched in diameter by about 0.4 mm and compressed up to 1 mm, so that the head 9 of the pedicle screw 2 can be tilted therein.
- the inside of the collet 7 is concave, expediently of hollow-spherical shape.
- the cavity 6 extends in the axial direction upwards so far into the channel 5 that the collet 7, or the preferably hollow cylindrical intermediate element 12 lying thereon (for example in the form of a washer), through the long beam 1 inserted into the channel 5 - if this is fixed axially and rotatively in the channel 5 by means of the clamping means 10 - can be axially pressed downwards.
- the diameter of the collet 7 is reduced, so that the head 9 of the pedicle screw 2 previously clicked into the collet 7 from below is clamped and is fixed in its relative position to the Aut Spotifykopt 3 (and thus to the long carrier 1). Thanks to the decoupling between the collet 7 and the intermediate element 12, the head 9 is uniformly surrounded, which leads to an optimal strength of the connection between the receiving head 3 and the pedicle screw 2.
- the clamping means 10 has an external thread de 19 and the channel 5 has a corresponding internal thread 21 in the area of the two jocn-like legs 20.
- an internal hexagon can also be used.
- the function of the intermediate element 12 in this special case is merely to enable the transfer of the crate from the long beam to the collet 7, which would otherwise be easily tilted in the cavity 6, as evenly as possible.
- the head 9 of the pedicle screw 2 is preferably provided at its upper end with a hexagon socket 23 in order to be able to screw the pedicle screw 2 into the bone by means of a hexagon screwdriver.
- FIG. 3 shows a variant of the device according to the invention, in which the receiving head 3 has a threaded through bore 13 communicating with the channel 5, which is open at the top and into which a clamping means 10 with a hexagon socket 24 can be screwed in such a way that it is in the channel 5 introduced Langstrager 1 is axially and rotationally fixable.
- FIG. 4 shows a further variant of the device according to the invention according to FIG. 3, in which the channel 5 is open to the side, around the long beam 1 laterally
- the clamping means 10 can also have a transverse slot 22 and an internal thread 30.
- the transverse slot 22 and the internal thread 30 serve to receive a manipulation device (not shown in the drawing).
- the channel 5 shows a further variant of the device according to the invention, in which the channel 5 is the same as in the variant according to FIG. 4 on the side.
- the autokead 3 has an external thread 15 with a transverse slot 25 and an internal thread 30, via which the hollow cylindrical sleeve 16 with the recesses 18 can be slipped onto the longitudinal beam 1.
- the sleeve 16 can be clamped with the nut 17, which has an internal thread corresponding to the external thread 15, against the longitudinal member 1 inserted into the channel 5, so that the longitudinal member 1 is fixed axially and rotationally on the one hand and on the other hand to the intermediate element 12 or via presses the opening 11 onto the collet 7.
- the receiving head 3 has a plate-like design; in addition to the conically downwardly tapering cavity 6 with the central axis 4, it contains the channel 5, which is transverse to the latter and is closed all around - for receiving the longitudinal carrier 1 with the longitudinal axis 32.
- the fixing of the clamping tongues 7 takes place via the clamping means 10, which prints the washer 12.
- the washer 12 can also be left with this large number of problems, so that the clamping device prints directly onto the clamping teeth 7. As a result of the pressure on the clamping teeth 7, this leads downward within the conically tapering cavity 6 and thereby narrows in diameter, so that a preferably spherical head 9 of a pedicle screw 2 inserted therein is blocked.
- the longitudinal beam is fixed separately by an additional set screw 31, which can be screwed from above into a bore communicating with the channel 5 until it contacts the long beam 1.
- the preferably spherical head 9 of the pedicle screw 2 can be provided with a device instead of the hexagon socket in order to be able to insert an extension (not shown in the drawing) which enables manipulation of the pedicle screw 2 by the clamping means 10 (this requires a large, continuous opening) .
- the connection between pedicle screw 2 and the extension is preferably reversible and rotation, zuq and pressure stable.
- the variant of the device according to the invention shown in FIG. 7 shows the use of a tensioning means 10 and a tensioning screw 36.
- the tensioning screw 36 is screwed into the mounting head and only fixes the ball coupling 9 of the pedicle screw 2.
- the screw can thus also be used blocked Kugelkopl 9 are moved along the long support without losing the angle between the long support 1 and pedicle screw 2.
- the clamping means 10 for fixing the long support is integrated in the clamping screw 36.
- the clamping means 10 is only tightened to block the long beam 1 after the Kugeikopt 9 has been fixed by the clamping screw 36.
- the long support 1 can be accommodated in the receiving head 3, as shown in FIG.
- the previous series of rows of the intermediate element 12 on the long beam 1 is omitted. It is also possible to provide the intermediate element with a lateral channel 5 according to FIG. 4.
- the intermediate element 12 is preferably mounted from the side of the collet 7.
- a rim 39 on the intermediate element 12 prevents the intermediate element 12 from slipping up out of the take-up head 3. The downward slipping is prevented by the tensioning element 7 prevented.
- a safety sleeve 41 prevents the take-up head from expanding when the tension screw 36 is tightened.
- a tension nut 38 similar to that shown in FIG. 9 is also possible.
- FIG. 8 shows a further variant of the device according to the invention.
- a second clamping screw 36 fixes the Kugeikopt 9 via the intermediate element 12 without test-clamping the long beam.
- the tensioning means 10, which serves to fix the long beam 1 is integrated in the intermediate element 12, which is pulled up further and provided with an internal thread 42.
- the intermediate element 12 has a closed threaded bore 42 which is still at the top.
- the closed base of the intermediate element 12 allows the collet 7 to be printed homogeneously.
- the long carrier 1 can be received in the receiving head 3 through an upwardly ot channel 5. It is also possible to receive the long beam 1 through a bore as shown in FIG.
- the long beam 1 can be accommodated in the intermediate element 12 through a bore 43. However, here the intermediate element 12 must be lined up with the carrier 1 before the long carrier 1 is inserted into the receiving head 3.
- An upward opening channel 5 on the intermediate element 12 as shown in FIG. 7 is also possible if the diameter of the long beam 1 is approximately 3/5 of the core diameter of the internal thread 42.
- a safety sleeve 41 prevents the take-up head from expanding when the tensioning screw 36 is tightened.
- a tensioning nut 38 similar to that shown in FIG. 9 is also possible.
- the variant of the device according to the invention shown in FIG. 9 is characterized, as shown in FIG. 8, by a raised intermediate element 12 and clamping means 10 integrated therein for blocking the long-arm.
- the collet 7 is blocked by a clamping nut 38.
- This clamping nut 38 presses the intermediate element 12 and the clamping element 7, as a result of which the ball lens 9 is fixed without the long support being clamped.
- a second clamping means 10 runs in the intermediate element 12 and clamps the long beam 1 firmly.
- the fixings of Kugeikopt 9 and Langstrager 1 are mechanically decoupled.
- the long carrier can be received in the autotope 3 through an upwardly ot channel 5.
- the long beam 1 can be accommodated in the intermediate element 12 by means of a bore 43 according to FIG. 8.
- an intermediate element 12 according to FIG. 9 provided with an upper otten channel 37 according to FIG.
- the long beam 1 can then s intermediate element 12 from above be introduced.
- a preliminary series of rows of the intermediate element 12 on the long beam 1 can be omitted.
- the assembly of the intermediate element 12 is preferably carried out from the side of the collet 7.
- a board 39 on the intermediate element 12 prevents the intermediate element 12 from slipping out of the top of the housing. Slipping down is prevented by the tensioning element 7.
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CH1996/000437 WO1998025534A1 (de) | 1996-12-12 | 1996-12-12 | Vorrichtung zur verbindung eines längsträgers mit einer pedikelschraube |
CA002275250A CA2275250C (en) | 1996-12-12 | 1996-12-12 | Device for connecting a longitudinal support to a pedicle screw |
US09/319,732 US6063090A (en) | 1996-12-12 | 1996-12-12 | Device for connecting a longitudinal support to a pedicle screw |
KR10-1999-7005290A KR100417222B1 (ko) | 1996-12-12 | 1996-12-12 | 페디클 스크류와 횡방향 지지대를 연결하기 위한 장치 |
DE59610225T DE59610225D1 (de) | 1996-12-12 | 1996-12-12 | Vorrichtung zur verbindung eines langstragers mit einer pedikelschraube |
ES96939801T ES2191775T3 (es) | 1996-12-12 | 1996-12-12 | Dispositivo para conectar un soporte longitudinal con un tornillo pedicular. |
AU76901/96A AU732351B2 (en) | 1996-12-12 | 1996-12-12 | Device for the connection of a longitudinal support with a pedicle screw |
AT96939801T ATE234046T1 (de) | 1996-12-12 | 1996-12-12 | Vorrichtung zur verbindung eines langstragers mit einer pedikelschraube |
EP96939801A EP0951245B1 (de) | 1996-12-12 | 1996-12-12 | Vorrichtung zur verbindung eines langstragers mit einer pedikelschraube |
JP52605398A JP3766107B2 (ja) | 1996-12-12 | 1996-12-12 | 縦材を脊柱茎ねじと結合する装置 |
HK00101718A HK1022617A1 (en) | 1996-12-12 | 2000-03-21 | Device for connecting a longitudinal support to a pedicle screw |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CH1996/000437 WO1998025534A1 (de) | 1996-12-12 | 1996-12-12 | Vorrichtung zur verbindung eines längsträgers mit einer pedikelschraube |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998025534A1 true WO1998025534A1 (de) | 1998-06-18 |
Family
ID=4550465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CH1996/000437 WO1998025534A1 (de) | 1996-12-12 | 1996-12-12 | Vorrichtung zur verbindung eines längsträgers mit einer pedikelschraube |
Country Status (11)
Country | Link |
---|---|
US (1) | US6063090A (de) |
EP (1) | EP0951245B1 (de) |
JP (1) | JP3766107B2 (de) |
KR (1) | KR100417222B1 (de) |
AT (1) | ATE234046T1 (de) |
AU (1) | AU732351B2 (de) |
CA (1) | CA2275250C (de) |
DE (1) | DE59610225D1 (de) |
ES (1) | ES2191775T3 (de) |
HK (1) | HK1022617A1 (de) |
WO (1) | WO1998025534A1 (de) |
Cited By (62)
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EP0986338A4 (de) * | 1997-02-11 | 2000-03-22 | Sdgi Holdings Inc | Mehrachsige-knochenschraubeanordnung |
WO2000042930A1 (en) * | 1999-01-25 | 2000-07-27 | Mullane Thomas S | Spinal fixation system |
WO2001050967A1 (en) * | 2000-01-13 | 2001-07-19 | Camargo Paes Vera Lucia | Improved pedicular screw |
DE10164323C1 (de) * | 2001-12-28 | 2003-06-18 | Biedermann Motech Gmbh | Verschlußeinrichtung zum Sichern eines stabförmigen Elements in einem mit einem Schaft verbundenen Halteelement |
WO2004052219A1 (de) * | 2002-12-06 | 2004-06-24 | Synthes Ag Chur | Vorrichtung für die osteosynthese |
WO2006005198A1 (de) | 2004-07-12 | 2006-01-19 | Synthes Gmbh | Vorrichtung zur dynamischen fixierung von knochen |
WO2007047711A2 (en) * | 2005-10-20 | 2007-04-26 | Warsaw Orthopedic, Inc. | Bottom loading multi-axial screw assembly |
EP1883376A2 (de) * | 2005-05-27 | 2008-02-06 | Roger P. Jackson | Polyaxiale knochenschraube mit schaftgelenk-druckeinsatz und verfahren |
EP1935358A1 (de) * | 2006-12-22 | 2008-06-25 | BIEDERMANN MOTECH GmbH | Knochenverankerungsvorrichtung |
US7766946B2 (en) | 2005-07-27 | 2010-08-03 | Frank Emile Bailly | Device for securing spinal rods |
US7766944B2 (en) | 2002-05-21 | 2010-08-03 | Peter Metz-Stavenhagen | Anchoring element for fastening a rod of a device for adjusting a human or animal vertebral column on a vertebra |
CN101500500B (zh) * | 2006-06-05 | 2011-05-11 | 特雷伯有限公司 | 脊椎的固定装置 |
US7951175B2 (en) | 2005-03-04 | 2011-05-31 | Depuy Spine, Inc. | Instruments and methods for manipulating a vertebra |
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WO2012030712A1 (en) * | 2010-08-30 | 2012-03-08 | Zimmer Spine, Inc. | Polyaxial pedicle screw |
DE102011053295A1 (de) * | 2011-09-06 | 2013-03-07 | Aesculap Ag | Polyaxiale Pedikelschraube mit provisorischer Fixierung |
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Also Published As
Publication number | Publication date |
---|---|
AU7690196A (en) | 1998-07-03 |
DE59610225D1 (de) | 2003-04-17 |
CA2275250C (en) | 2004-06-29 |
JP3766107B2 (ja) | 2006-04-12 |
KR100417222B1 (ko) | 2004-02-05 |
CA2275250A1 (en) | 1998-06-18 |
ATE234046T1 (de) | 2003-03-15 |
ES2191775T3 (es) | 2003-09-16 |
AU732351B2 (en) | 2001-04-26 |
HK1022617A1 (en) | 2000-08-18 |
KR20000057562A (ko) | 2000-09-25 |
JP2001505469A (ja) | 2001-04-24 |
EP0951245B1 (de) | 2003-03-12 |
US6063090A (en) | 2000-05-16 |
EP0951245A1 (de) | 1999-10-27 |
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