WO1998017202A1 - Method and apparatus for endovascular venous transplantation - Google Patents
Method and apparatus for endovascular venous transplantation Download PDFInfo
- Publication number
- WO1998017202A1 WO1998017202A1 PCT/US1997/018736 US9718736W WO9817202A1 WO 1998017202 A1 WO1998017202 A1 WO 1998017202A1 US 9718736 W US9718736 W US 9718736W WO 9817202 A1 WO9817202 A1 WO 9817202A1
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- WO
- WIPO (PCT)
- Prior art keywords
- blood vessel
- stent
- valve
- vein
- venous
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2415—Manufacturing methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2475—Venous valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30448—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
- A61F2002/30449—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives the adhesive being cement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
Abstract
The present invention provides a device (10) for endovascular deployment within a first blood vessel (2) comprising a preselected portion of a second blood vessel (4) having a predetermined length and diameter, and attached to at least a portion of an inner surface (6) of a radially self-expanding stent (8). The second blood vessel graft (4) can be any vessel of the body, but is preferably a vein or an artery. Sutures (12) can be used to attach the stent (8) to the second blood vessel (4).
Description
METHOD AND APPARATUS FOR ENDO VASCULAR VENOUS TRANSPLANTATION
FIELD OF THE INVENTION
The present invention relates to a device and method for endovascular
deployment of a fresh or cryopreserved venous graft at a predetermined site in a patient.
BACKGROUND OF THE INVENTION
Venous insufficiency is a widespread problem, affecting up to 20 million people
in the United States alone. (See, Taheri SA, Rigan D, Wels P, Mentzer R, Shores Rm.
Experimental prosthetic vein valve. Am J Surg 1988; 156-144.) The chronicity of the
disease leads to great expense in both physical morbidity and loss of work.
The problems of valvular insufficiency and outflow obstruction lead to a
common pathway of increased venous pressure, and subsequent limb edema, skin
changes, and eventual ulceration. Although current techniques are often effective and
produce initial healing, they leave the extremity subject to recurrence, and require
diligent maintenance.
Direct treatment of the primary problems include conventional surgical valve
replacement or repair to restore valvular competency, and vein replacement to alleviate
outflow obstruction (See, Taheri SA, Lazar L, Elias S. Status of vein valve transplant
after 12 months. Arch Surg 1982; 117:1313-1317; Bry JD, Muto PA, O'Donnell TF,
Isaacson LA. The clinical and hemodynamic results after axillary-to-popliteal vein valve
transplantation. J Vase Surg 1995; 21 : 110-119; and Arch Surg 1967; 95:826-834).
These types of reconstruction require relatively extensive dissection and mobilization of
already diseased vessels, and, as such, the repaired vessel may be prone to thrombosis and dilatation with recurrent obstruction and incompetence, leading to recurrent venous
hypertension.
Two patents to Dardik et al., U. S. Patent No. 5,131,908 and U.S. Patent
4,990,131, both for a "Tubular Prosthesis for Vascular Reconstructive Surgery and
Process for Preparing Same" are directed to the use of chemically fixed (tanned)
umbilical cord vessels which are designed for conventional surgical implantation. The
chemically fixed vessel portions may be attached to an external mesh support which
allows for ingrowth of extra fibrocollagenous tissue from outside the graft at the surgical implantation site.
Likewise, U.S. Patent No. 5,500,014 to Quijano et al., for a "Biological Valvular
Prosthesis" is directed to the use of a chemically fixed biological derived conduit that
has at least one integrally formed tissue valve for conventional surgical implantation. A
process of chemical fixation utilizing glutaraldehyde is used to chemically fix the valve so that it normally remains open and closes upon the exertion of back pressure. A support cage or external prosthesis can be added to strengthen the valve. Additionally,
DeLaria et al., "Hemodynamic evaluation of a bioprosthetic venous prosthesis", J. Vase
Surg. (United States) Oct. 1993, 18(4) p. 577-84 is directed to utilizing glutaraldehyde
fixed bovine jugular veins as a venous valve substitute for conventional surgical implantation.
These conventional valve transplants are prone to thrombosis and graft dilation,
with subsequent incompetence. Thus, there is a need in the art for a device and a
minimally invasive method of graft delivery which minimizes complications associated with conventional. Accordingly, the present invention provides a device and methods
for the construction and endovascular placement of a native fresh or cyro preserved
venous valve-stent graft in a vein as a potential new treatment of valvular incompetence.
Venous reflux is also a key factor in the widespread and often debilitating
disease of venous insufficiency. Valve transplantation has been successfully performed
to restore valve competency, but necessarily involves a relatively large operative
procedure for recovery of the donor valve segment and graft interposition to the
recipient vein. Accordingly there exists a need for a technique of valve transplantation
requiring minimally invasive methods of donor valve harvest, and valve deployment in the recipient vein. Accordingly, the present invention provides a fresh or cyro-preserved
section of donor vein mounted on a stent for endovascular deployment in a recipient
vein.
SUMMARY OF THE INVENTION
The present invention provides a device and a method of endovascular delivery
and deployment of a self-expanding stent which surrounds a section of fresh or
cryopreserved venous tissue. An appropriately sized fresh or cyro preserved venous
graft is sutured in position within the lumen of a standard endovascular stent, e.g., a Wallstent (Schneider). Deployment is generally directed under fluoroscopic
visualization.
The endovascular venous graft of the present invention is believed to be
particularly useful in treating dialysis associated central venous stenosis or central
venous stasis. Therefore, the endovascular venous grafts of the invention may also contain one or more venous valves as directed by the patient's needs.
BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1 is a photograph which shows, from top to bottom, an introducer and dilator for
deployment of the stent and attached venous graft. A scalpel is shown at bottom for
referencing size.
Figure 2 is a close up photograph of the stent of one embodiment of the invention
containing the venous graft sutured within the lumen of the stent.
Figure 3 is a photograph showing at left the graft/stent preloaded on the introducer
catheter with dilator in position for deployment. A scalpel is shown at right for
referencing size.
Figure 4 is a side elevational drawing of the stent with a venous graft sutured in the
lumen.
Figure 5 is a cross-sectional view of the stent/graft deployed at within a patient's blood
vessel.
DETAILED DESCRIPTION OF THE INVENTION
As shown in Figures 4-5, the present invention provides a device 10 for
endovascular deployment within a first blood vessel 2 comprising: a preselected portion
of a second blood vessel 4 having a predetermined length and diameter and attached to
at least a portion of an inner surface 6 of a radially self-expanding stent 8. The second
blood vessel (graft vessel) can be any vessel of the body but is preferably a vein or an
artery.
In one embodiment the second blood vessel is a vein and the preselected portion
contains at least one valve, however the venous graft need not contain a valve. In the
embodiment shown in Figures 4-5 the second blood vessel portion (graft) 4 is attached
to stent 8 by sutures 12. One of skill in the art will recognize that other means of
attachment are possible, including, for example, biocompatable cements such as fibrin
glue or collagen glue.
The preselected portion of the second blood vessel can be venous graft material that is harvested and deployed as fresh tissue. In one embodiment, the preselected
portion of the second blood vessel is cryopreserved tissue.
Figures 1-3 are actual color photographs of one embodiment of the device of the
invention as set forth and described in Figures 4-5. Figures 1-3 are not necessary for an
understanding of the invention and are presented merely for clarification of the
embodiments set forth and described herein..
The present invention also provides a method of treating a predetermined section
of a first blood vessel, comprising: placing, by endovascular means, a preselected
portion of a second blood vessel having a predetermined length and diameter and attached to at least a portion of an inner surface of a radially self-expanding stent within
the first blood vessel at the predetermined section. The predetermined section can be
any section of any vessel within the body.
EXAMPLE 1
MATERIALS AND METHODS
In an ex vivo model, a segment of native vein containing a valve is placed inside
a self expanding stent, and deployed inside a vein from a remote access site. After
deployment, the valve is inspected angioscopically from both the downstream and
upstream ends, demonstrating valve patency and competence. Photographs of the
valve-stent construction and the deployment apparatus are presented as Figures 1-3.
A segment of external jugular vein containing a valve was exposed and mobilized
in a dog. The valve was examined for competence and patency using a strip test and
Doppler flow probe. The segment was excised and sewn inside a self-expanding
stainless steel stent, leaving only 1-2 mm of stent exposed on each end (Figs. 1-2). The
apparatus was then compressed and loaded into a #14F introducer (Fig. 1 and 3). The
valve stent was deployed by withdrawing the introducer over a #12F dilator, uncovering
the valve-stent (Fig. 3).
To test the device, it was deployed in transparent 3/8" plastic tubing. Patency
and competency of the device was determined by direct angioscopic examination of the
valve while injecting the tubing with saline both retrograde and antegrade.
DESCRIPTION OF A PRESENTLY PREFERRED
EMBODIMENT OF THE DEVICE
Components:
1) 4 cm length of axillary vein, harvested from the patient's upper
arm, which contains a hemodynamically competent valve.
2) Wallstent (Schneider, Inc. U.S.A.), 10 mm diameter, 4 cm
length.
3) The vein is placed inside the self expanding Wallstent and sutured
in situ (Figs. 2 and 4).
4) The Wallstent is compressed and placed inside a 12Fr sheath (Fig. 3).
5) The self expanding stent opens spontaneously exposing the valve
to venous flow.
One of skill in the art will appreciate that the size of the graft, stent and
deployment device as well as the type of stent can vary depending upon the particular area of the patient being treated and the pathological condition associated therewith.
Likewise, the stent can be constructed of any of a number of suitable materials all well
known in the art such as, e.g., stainless steel or a biocompatable polymer.
The venous graft tissue can be harvested fresh and utilized or a cryopreserved specimen can be utilized. Methods are known in the art for cryopreservation of blood
vessel tissue such as, for example, those utilized by CryoLife, Inc. of Atlanta, GA.
RESULTS
Patency and competency of the valve-stent were confirmed. No flaps or folds
were observed after 1 week of implantation. The valve leaflets functioned in a normal
fashion with both retrograde and antegrade injection. The methods and devices
demonstrate herein maintenance of patency and competency and offer encouraging new
minimally invasive methods of therapy.
EXAMPLE 2
METHODS AND MATERIALS
Five female goats were studied. A valve-stent (V-S) was constructed in the
following method: A valve-containing segment of external jugular vein was excised
using an endoscopic subcutaneous video-assisted technique; the segment was sutured
inside a self-expanding stainless steel stent Wallstent, covering all but the terminal 1-2
mm of each end of the stent. The V-S was compressed and loaded into a 14 Fr
introducer sheath which was then inserted retrograde into the contralateral external
jugular vein through a small cutdown and venotomy. The V-S was deployed by
withdrawing the sheath over a 12 Fr dilator, leaving the expanded stent in place. The
goat was given 100 u/kg heparin SQ every 12 hours. At one week, patency and competency was evaluated with a flow probe, in situ retrograde and antegrade
endoscopy, and strip test. The V-S was excised and inspected histologically.
RESULTS
All five V-S were patent with competent valve function. A small non-occlusive
luminal clot was attached to the downstream exposed stent struts on two V-S.
Microscopic evaluation demonstrated no valve pathology.
CONCLUSION
In this goat model, we have demonstrated the feasibility of venous valve
transplantation, maintaining patency and competency, using minimally invasive
techniques of endovascular delivery and deployment.
The techniques, methods and devices of the present invention are discussed further in recent publications, e.g., in "endoscopic Venous Valve transplantation with a
Valve-Stent Device", Ofenloch J.C. et al, Ann Vase Surg 1997; 11;62-67, and Chapter
32 (entitled "Valve Stent: A Technique for Endovascular Delivery of Functioning
Venous Valves") from the text "Current Critical Problems in Vascular Surgery" Volume
8, edited by Frank J. Veitch M. D. and published by Quality Medical Publishing, St. Louis Missouri (Critical Problems in Vascular Surgery 1997; 32:206-209 (in press)).
Throughout this application various publications and methods are referenced.
The disclosures of these publications and the referenced methods in their entireties are
hereby incorporated by reference into this application in order to more fully describe the
state of the art to which the invention pertains.
Claims
1. A device for endovascular deployment within a first blood vessel comprising a preselected portion of a second blood vessel having a predetermined length and
diameter and attached to at least a portion of an inner surface of a radially self- expanding stent.
2. The device of claim 1, wherein the second blood vessel is an artery.
3. The device of claim 1, wherein the second blood vessel is a vein.
4. The device of claim 3, wherein the second blood vessel is a vein and the
preselected portion contains at least one valve.
5. The device of claim 1, wherein the preselected portion of the second blood
vessel is attached to the stent by at least one suture.
6. The device of claim 1, wherein the preselected portion of the second blood is attached to the stent by a biocompatable cement.
7. The device of claim 6, wherein the biocompatable cement is selected from the
group consisting of fibrin glue and collagen glue.
8. The device of claim 1, wherein the preselected portion of the second blood
vessel is a venous graft material that is harvested and deployed as fresh tissue.
9. The device of claim 1, wherein the preselected portion of the second blood
vessel is a cryopreserved tissue.
10. The device of claim 1, wherein the stent is a hollow tubular stent and comprised
of a biocompatable material selected from the group consisting of a metal, a polymer, a
plastic or combinations thereof.
11. A method of treating a predetermined section of a first blood vessel, comprising:
placing, by endovascular means, a preselected portion of a second blood vessel having a predetermined length and diameter and attached to at least a portion of an inner
surface of a radially self-expanding stent within the first blood vessel at the
predetermined section.
12. The method of claim 10, wherein the predetermined section within the first blood
vessel is a diseased section of a patient's vein.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU49064/97A AU4906497A (en) | 1996-10-22 | 1997-10-21 | Method and apparatus for endovascular venous transplantation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2874696P | 1996-10-22 | 1996-10-22 | |
US60/028,746 | 1996-10-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998017202A1 true WO1998017202A1 (en) | 1998-04-30 |
Family
ID=21845189
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/018736 WO1998017202A1 (en) | 1996-10-22 | 1997-10-21 | Method and apparatus for endovascular venous transplantation |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU4906497A (en) |
WO (1) | WO1998017202A1 (en) |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1933766A2 (en) * | 2005-09-21 | 2008-06-25 | Medtronic, Inc. | Composite heart valve apparatus manufactured using techniques involving laser machining of tissue |
US8353953B2 (en) | 2009-05-13 | 2013-01-15 | Sorin Biomedica Cardio, S.R.L. | Device for the in situ delivery of heart valves |
US8403982B2 (en) | 2009-05-13 | 2013-03-26 | Sorin Group Italia S.R.L. | Device for the in situ delivery of heart valves |
US8512397B2 (en) | 2009-04-27 | 2013-08-20 | Sorin Group Italia S.R.L. | Prosthetic vascular conduit |
US8540768B2 (en) | 2005-02-10 | 2013-09-24 | Sorin Group Italia S.R.L. | Cardiac valve prosthesis |
US8685084B2 (en) | 2011-12-29 | 2014-04-01 | Sorin Group Italia S.R.L. | Prosthetic vascular conduit and assembly method |
US8808369B2 (en) | 2009-10-05 | 2014-08-19 | Mayo Foundation For Medical Education And Research | Minimally invasive aortic valve replacement |
US8834563B2 (en) | 2008-12-23 | 2014-09-16 | Sorin Group Italia S.R.L. | Expandable prosthetic valve having anchoring appendages |
US8840661B2 (en) | 2008-05-16 | 2014-09-23 | Sorin Group Italia S.R.L. | Atraumatic prosthetic heart valve prosthesis |
US9056008B2 (en) | 2006-12-19 | 2015-06-16 | Sorin Group Italia S.R.L. | Instrument and method for in situ development of cardiac valve prostheses |
US9161836B2 (en) | 2011-02-14 | 2015-10-20 | Sorin Group Italia S.R.L. | Sutureless anchoring device for cardiac valve prostheses |
US9168105B2 (en) | 2009-05-13 | 2015-10-27 | Sorin Group Italia S.R.L. | Device for surgical interventions |
US9248017B2 (en) | 2010-05-21 | 2016-02-02 | Sorin Group Italia S.R.L. | Support device for valve prostheses and corresponding kit |
US9289289B2 (en) | 2011-02-14 | 2016-03-22 | Sorin Group Italia S.R.L. | Sutureless anchoring device for cardiac valve prostheses |
US9848981B2 (en) | 2007-10-12 | 2017-12-26 | Mayo Foundation For Medical Education And Research | Expandable valve prosthesis with sealing mechanism |
US9867695B2 (en) | 2004-03-03 | 2018-01-16 | Sorin Group Italia S.R.L. | Minimally-invasive cardiac-valve prosthesis |
US10058313B2 (en) | 2011-05-24 | 2018-08-28 | Sorin Group Italia S.R.L. | Transapical valve replacement |
WO2022084013A1 (en) * | 2020-10-23 | 2022-04-28 | Biotronik Ag | Automated method for the effective fixation of x-ray markers in vascular implants |
US11504231B2 (en) | 2018-05-23 | 2022-11-22 | Corcym S.R.L. | Cardiac valve prosthesis |
US11969341B2 (en) | 2022-11-18 | 2024-04-30 | Corcym S.R.L. | Cardiac valve prosthesis |
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US5500014A (en) * | 1989-05-31 | 1996-03-19 | Baxter International Inc. | Biological valvular prothesis |
US5556414A (en) * | 1995-03-08 | 1996-09-17 | Wayne State University | Composite intraluminal graft |
US5645581A (en) * | 1993-11-30 | 1997-07-08 | Zurbruegg; Heinz Robert | Vascular prosthesis |
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1997
- 1997-10-21 AU AU49064/97A patent/AU4906497A/en not_active Abandoned
- 1997-10-21 WO PCT/US1997/018736 patent/WO1998017202A1/en active Application Filing
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US5352240A (en) * | 1989-05-31 | 1994-10-04 | Promedica International, Inc. | Human heart valve replacement with porcine pulmonary valve |
US5500014A (en) * | 1989-05-31 | 1996-03-19 | Baxter International Inc. | Biological valvular prothesis |
US5645581A (en) * | 1993-11-30 | 1997-07-08 | Zurbruegg; Heinz Robert | Vascular prosthesis |
US5556414A (en) * | 1995-03-08 | 1996-09-17 | Wayne State University | Composite intraluminal graft |
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