WO1998015969A3 - Mass spectrometers and methods for rapid screening of libraries of different materials - Google Patents

Mass spectrometers and methods for rapid screening of libraries of different materials Download PDF

Info

Publication number
WO1998015969A3
WO1998015969A3 PCT/US1997/018147 US9718147W WO9815969A3 WO 1998015969 A3 WO1998015969 A3 WO 1998015969A3 US 9718147 W US9718147 W US 9718147W WO 9815969 A3 WO9815969 A3 WO 9815969A3
Authority
WO
WIPO (PCT)
Prior art keywords
materials
methods
libraries
different materials
mass spectrometers
Prior art date
Application number
PCT/US1997/018147
Other languages
French (fr)
Other versions
WO1998015969A2 (en
Inventor
W Henry Weinberg
Eric W Mcfarland
Peijun Cong
Shenheng Guan
Original Assignee
Symyx Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27574147&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1998015969(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/898,715 external-priority patent/US6030917A/en
Priority to AT97910017T priority Critical patent/ATE222401T1/en
Priority to DE69714789T priority patent/DE69714789T4/en
Priority to EP97910017A priority patent/EP1019947B1/en
Priority to ES97910017T priority patent/ES2182040T3/en
Application filed by Symyx Technologies Inc filed Critical Symyx Technologies Inc
Priority to AU47493/97A priority patent/AU4749397A/en
Priority to CA002267908A priority patent/CA2267908C/en
Priority to DK97910017T priority patent/DK1019947T3/en
Priority to DE69714789A priority patent/DE69714789D1/en
Publication of WO1998015969A2 publication Critical patent/WO1998015969A2/en
Publication of WO1998015969A3 publication Critical patent/WO1998015969A3/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/22Details, e.g. general constructional or apparatus details
    • G01N29/24Probes
    • G01N29/2418Probes using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics
    • G01N29/2425Probes using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics optoacoustic fluid cells therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/006Palladium compounds
    • C07F15/0066Palladium compounds without a metal-carbon linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/04Nickel compounds
    • C07F15/045Nickel compounds without a metal-carbon linkage
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00Methods specially adapted for identifying library members
    • C40B20/08Direct analysis of the library members per se by physical methods, e.g. spectroscopy
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/08Methods of screening libraries by measuring catalytic activity
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/18Libraries containing only inorganic compounds or inorganic materials
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/12Apparatus specially adapted for use in combinatorial chemistry or with libraries for screening libraries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01HMEASUREMENT OF MECHANICAL VIBRATIONS OR ULTRASONIC, SONIC OR INFRASONIC WAVES
    • G01H13/00Measuring resonant frequency
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J4/00Measuring polarisation of light
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21Polarisation-affecting properties
    • G01N21/211Ellipsometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251Colorimeters; Construction thereof
    • G01N21/253Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6402Atomic fluorescence; Laser induced fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00Investigating or analyzing materials by the use of thermal means
    • G01N25/20Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
    • G01N25/48Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
    • G01N25/4806Details not adapted to a particular type of sample
    • G01N25/4813Details not adapted to a particular type of sample concerning the measuring means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02Analysing fluids
    • G01N29/022Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02Analysing fluids
    • G01N29/036Analysing fluids by measuring frequency or resonance of acoustic waves
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/22Details, e.g. general constructional or apparatus details
    • G01N29/24Probes
    • G01N29/2418Probes using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/22Details, e.g. general constructional or apparatus details
    • G01N29/30Arrangements for calibrating or comparing, e.g. with standard objects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/34Generating the ultrasonic, sonic or infrasonic waves, e.g. electronic circuits specially adapted therefor
    • G01N29/348Generating the ultrasonic, sonic or infrasonic waves, e.g. electronic circuits specially adapted therefor with frequency characteristics, e.g. single frequency signals, chirp signals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/36Detecting the response signal, e.g. electronic circuits specially adapted therefor
    • G01N29/42Detecting the response signal, e.g. electronic circuits specially adapted therefor by frequency filtering or by tuning to resonant frequency
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/44Processing the detected response signal, e.g. electronic circuits specially adapted therefor
    • G01N29/4409Processing the detected response signal, e.g. electronic circuits specially adapted therefor by comparison
    • G01N29/4418Processing the detected response signal, e.g. electronic circuits specially adapted therefor by comparison with a model, e.g. best-fit, regression analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/44Processing the detected response signal, e.g. electronic circuits specially adapted therefor
    • G01N29/4409Processing the detected response signal, e.g. electronic circuits specially adapted therefor by comparison
    • G01N29/4427Processing the detected response signal, e.g. electronic circuits specially adapted therefor by comparison with stored values, e.g. threshold values
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N9/00Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity
    • G01N9/002Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity using variation of the resonant frequency of an element vibrating in contact with the material submitted to analysis
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409Sample holders or containers
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • B01J2219/00317Microwell devices, i.e. having large numbers of wells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00364Pipettes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00378Piezo-electric or ink jet dispensers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00427Means for dispensing and evacuation of reagents using masks
    • B01J2219/0043Means for dispensing and evacuation of reagents using masks for direct application of reagents, e.g. through openings in a shutter
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00436Maskless processes
    • B01J2219/00443Thin film deposition
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/005Beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00511Walls of reactor vessels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00513Essentially linear supports
    • B01J2219/00515Essentially linear supports in the shape of strings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00513Essentially linear supports
    • B01J2219/0052Essentially linear supports in the shape of elongated tubes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00527Sheets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00527Sheets
    • B01J2219/00536Sheets in the shape of disks
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00585Parallel processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/0059Sequential processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061The surface being organic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614Delimitation of the attachment areas
    • B01J2219/00621Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623Immobilisation or binding
    • B01J2219/00626Covalent
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623Immobilisation or binding
    • B01J2219/00628Ionic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632Introduction of reactive groups to the surface
    • B01J2219/00637Introduction of reactive groups to the surface by coating it with another layer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00639Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00675In-situ synthesis on the substrate
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • B01J2219/00689Automatic using computers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00702Processes involving means for analysing and characterising the products
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00702Processes involving means for analysing and characterising the products
    • B01J2219/00704Processes involving means for analysing and characterising the products integrated with the reactor apparatus
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00722Nucleotides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00738Organic catalysts
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/00745Inorganic compounds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/00745Inorganic compounds
    • B01J2219/00747Catalysts
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/00745Inorganic compounds
    • B01J2219/0075Metal based compounds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/00745Inorganic compounds
    • B01J2219/0075Metal based compounds
    • B01J2219/00754Metal oxides
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/14Libraries containing macromolecular compounds and not covered by groups C40B40/06 - C40B40/12
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N11/10Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material
    • G01N11/16Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material by measuring damping effect upon oscillatory body
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N9/00Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity
    • G01N9/002Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity using variation of the resonant frequency of an element vibrating in contact with the material submitted to analysis
    • G01N2009/006Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity using variation of the resonant frequency of an element vibrating in contact with the material submitted to analysis vibrating tube, tuning fork
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2203/00Investigating strength properties of solid materials by application of mechanical stress
    • G01N2203/0058Kind of property studied
    • G01N2203/0092Visco-elasticity, solidification, curing, cross-linking degree, vulcanisation or strength properties of semi-solid materials
    • G01N2203/0094Visco-elasticity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/01Indexing codes associated with the measuring variable
    • G01N2291/014Resonance or resonant frequency
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/02Indexing codes associated with the analysed material
    • G01N2291/022Liquids
    • G01N2291/0224Mixtures of three or more liquids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/02Indexing codes associated with the analysed material
    • G01N2291/025Change of phase or condition
    • G01N2291/0255(Bio)chemical reactions, e.g. on biosensors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/02Indexing codes associated with the analysed material
    • G01N2291/025Change of phase or condition
    • G01N2291/0256Adsorption, desorption, surface mass change, e.g. on biosensors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/02Indexing codes associated with the analysed material
    • G01N2291/028Material parameters
    • G01N2291/02818Density, viscosity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/02Indexing codes associated with the analysed material
    • G01N2291/028Material parameters
    • G01N2291/02827Elastic parameters, strength or force
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/02Indexing codes associated with the analysed material
    • G01N2291/028Material parameters
    • G01N2291/02863Electric or magnetic parameters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/04Wave modes and trajectories
    • G01N2291/042Wave modes
    • G01N2291/0422Shear waves, transverse waves, horizontally polarised waves
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/04Wave modes and trajectories
    • G01N2291/042Wave modes
    • G01N2291/0423Surface waves, e.g. Rayleigh waves, Love waves
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/04Wave modes and trajectories
    • G01N2291/042Wave modes
    • G01N2291/0427Flexural waves, plate waves, e.g. Lamb waves, tuning fork, cantilever
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/10Number of transducers
    • G01N2291/106Number of transducers one or more transducer arrays
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/10Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using catalysis

Abstract

Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques are provided for rapidly characterizing compounds in combinatorial arrays of materials for discovering and/or optimizing new materials with specific desired properties. According to one aspect, a scanning mass spectrometer is used which includes an ionization chamber and a collector that outputs an electrical signal responsive to the quantity of gas ions contacting the collector surface. A conduit system selectively withdraws samples from the array of materials, passing the samples into the ionization chamber. In a specific embodiment, reactants are passed through the conduit system to the selected regions of interest on the substrate. Means are provided to selectively heat regions on the substrate.
PCT/US1997/018147 1996-10-09 1997-10-08 Mass spectrometers and methods for rapid screening of libraries of different materials WO1998015969A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE69714789A DE69714789D1 (en) 1996-10-09 1997-10-08 MEASURING SPECTROMETER AND METHOD FOR QUICK SIGHTING OF MATERIAL STORAGE BIBLIOTECES
DK97910017T DK1019947T3 (en) 1996-10-09 1997-10-08 Mass spectrometers and methods for rapid screening of libraries of various materials
DE69714789T DE69714789T4 (en) 1996-10-09 1997-10-08 MEASURING SPECTROMETER AND METHOD FOR QUICK SIGHTING OF MATERIAL STORAGE BIBLIOTECES
EP97910017A EP1019947B1 (en) 1996-10-09 1997-10-08 Mass spectrometers and methods for rapid screening of libraries of different materials
ES97910017T ES2182040T3 (en) 1996-10-09 1997-10-08 MASS SPECTROMETERS AND METHODS FOR QUICK TRACKING OF LIBRARIES OF DIFFERENT MATERIALS.
AT97910017T ATE222401T1 (en) 1996-10-09 1997-10-08 MEASUREMENT SPECTROMETER AND METHOD FOR RAPID VIEWING OF MATERIAL STORAGE LIBRARIES
AU47493/97A AU4749397A (en) 1996-10-09 1997-10-08 Mass spectrometers and methods for rapid screening of libraries of different materials
CA002267908A CA2267908C (en) 1996-10-09 1997-10-08 Mass spectrometers and methods for rapid screening of libraries of different materials

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US2810696P 1996-10-09 1996-10-09
US2810596P 1996-10-09 1996-10-09
US60/028,105 1996-10-09
US60/028,106 1996-10-09
US2925596P 1996-10-25 1996-10-25
US60/029,255 1996-10-25
US3536697P 1997-01-10 1997-01-10
US3520297P 1997-01-10 1997-01-10
US60/035,366 1997-01-10
US60/035,202 1997-01-10
US4898797P 1997-06-09 1997-06-09
US60/048,987 1997-06-09
US5094997P 1997-06-13 1997-06-13
US60/050,949 1997-06-13
US08/898,715 1997-07-22
US08/898,715 US6030917A (en) 1996-07-23 1997-07-22 Combinatorial synthesis and analysis of organometallic compounds and catalysts

Publications (2)

Publication Number Publication Date
WO1998015969A2 WO1998015969A2 (en) 1998-04-16
WO1998015969A3 true WO1998015969A3 (en) 2000-07-27

Family

ID=27574147

Family Applications (4)

Application Number Title Priority Date Filing Date
PCT/US1997/018177 WO1998015813A1 (en) 1996-10-09 1997-10-07 Infrared spectroscopy and imaging of libraries
PCT/US1997/018521 WO1998015805A1 (en) 1996-10-09 1997-10-08 Optical systems and methods for rapid screening of libraries of different materials
PCT/US1997/018192 WO1998015501A2 (en) 1996-10-09 1997-10-08 Systems and methods for characterization of materials and combinatorial libraries with mechanical oscillators
PCT/US1997/018147 WO1998015969A2 (en) 1996-10-09 1997-10-08 Mass spectrometers and methods for rapid screening of libraries of different materials

Family Applications Before (3)

Application Number Title Priority Date Filing Date
PCT/US1997/018177 WO1998015813A1 (en) 1996-10-09 1997-10-07 Infrared spectroscopy and imaging of libraries
PCT/US1997/018521 WO1998015805A1 (en) 1996-10-09 1997-10-08 Optical systems and methods for rapid screening of libraries of different materials
PCT/US1997/018192 WO1998015501A2 (en) 1996-10-09 1997-10-08 Systems and methods for characterization of materials and combinatorial libraries with mechanical oscillators

Country Status (9)

Country Link
US (10) US6541271B1 (en)
EP (5) EP0934515B1 (en)
AT (3) ATE319988T1 (en)
AU (4) AU4812097A (en)
CA (2) CA2267897C (en)
DE (4) DE69735411T2 (en)
DK (1) DK1019947T3 (en)
ES (1) ES2182040T3 (en)
WO (4) WO1998015813A1 (en)

Families Citing this family (414)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976896A (en) * 1994-06-06 1999-11-02 Idexx Laboratories, Inc. Immunoassays in capillary tubes
US7166470B2 (en) * 1994-10-18 2007-01-23 Symyx Technologies, Inc. Formation of combinatorial arrays of materials using solution-based methodologies
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US6063633A (en) 1996-02-28 2000-05-16 The University Of Houston Catalyst testing process and apparatus
US6706875B1 (en) * 1996-04-17 2004-03-16 Affyemtrix, Inc. Substrate preparation process
EP0914608A1 (en) * 1996-05-09 1999-05-12 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization
US6441901B2 (en) 1996-07-23 2002-08-27 Symyx Technologies, Inc. Optical systems and methods for rapid screening of libraries of different materials
US20050009081A1 (en) * 1996-07-23 2005-01-13 Symyx Technologies, Inc. Optical systems and methods for rapid screening of libraries of different materials
AU4662097A (en) 1996-10-01 1998-04-24 Symyx Technologies, Inc. Potential masking systems and methods for combinitorial library synthesis
EP0934515B1 (en) * 1996-10-09 2006-03-08 Symyx Technologies, Inc. Infrared spectroscopy and imaging of libraries
US6536944B1 (en) * 1996-10-09 2003-03-25 Symyx Technologies, Inc. Parallel screen for rapid thermal characterization of materials
US6188933B1 (en) * 1997-05-12 2001-02-13 Light & Sound Design Ltd. Electronically controlled stage lighting system
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US7112449B1 (en) * 2000-04-05 2006-09-26 Nanogram Corporation Combinatorial chemical synthesis
US6576906B1 (en) * 1999-10-08 2003-06-10 Symyx Technologies, Inc. Method and apparatus for screening combinatorial libraries for semiconducting properties
US20030104481A1 (en) * 1997-09-30 2003-06-05 Symyx Technologies Potential masking systems and methods for combinatorial library synthesis
US6494079B1 (en) * 2001-03-07 2002-12-17 Symyx Technologies, Inc. Method and apparatus for characterizing materials by using a mechanical resonator
US6393895B1 (en) 1997-10-08 2002-05-28 Symyx Technologies, Inc. Method and apparatus for characterizing materials by using a mechanical resonator
US6426226B1 (en) 1997-10-10 2002-07-30 Laboratory Catalyst Systems Llc Method and apparatus for screening catalyst libraries
ATE335498T1 (en) 1997-11-12 2006-09-15 Johnson & Johnson Pharm Res HIGH-THROUGHPUT METHOD FOR FUNCTIONAL CLASSIFICATION OF PROTEINS IDENTIFIED IN A GENOMIC EXPERIMENTAL APPROACH
DE19826303A1 (en) * 1998-06-12 1999-12-16 Studiengesellschaft Kohle Mbh A method for the comparative determination of physically or chemically induced heat coloration using infrared camera imaging
US6265226B1 (en) * 1998-04-03 2001-07-24 Symyx Technologies, Inc. Automated sampling methods for rapid characterization of polymers
US6866786B2 (en) * 1998-04-03 2005-03-15 Symyx Technologies, Inc. Rapid characterization of polymers
US6519032B1 (en) 1998-04-03 2003-02-11 Symyx Technologies, Inc. Fiber optic apparatus and use thereof in combinatorial material science
DE19822077A1 (en) * 1998-05-16 1999-11-18 Studiengesellschaft Kohle Mbh Preparation of library of spatially separted solids by wet-chemical methods on a removable reaction plate, used e.g. to screen for new catalysts or materials
WO2000004362A2 (en) * 1998-06-05 2000-01-27 The Penn State Research Foundation Method of screening compositions for electrocatalytic activity
US6919178B2 (en) 2000-11-21 2005-07-19 Sunesis Pharmaceuticals, Inc. Extended tethering approach for rapid identification of ligands
US6998233B2 (en) 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
US6483112B1 (en) 1998-07-14 2002-11-19 E. Neil Lewis High-throughput infrared spectroscopy
ATE472097T1 (en) 1998-07-14 2010-07-15 Us Gov Health & Human Serv HIGH-THROUGHPUT INFRARED SPECTROSCOPY
US6306658B1 (en) * 1998-08-13 2001-10-23 Symyx Technologies Parallel reactor with internal sensing
EP1586373A1 (en) * 1998-08-13 2005-10-19 Symyx Technologies, Inc. Reactor control system
US6528026B2 (en) 1998-08-13 2003-03-04 Symyx Technologies, Inc. Multi-temperature modular reactor and method of using same
EP1260267A3 (en) * 1998-08-13 2005-09-21 Symyx Technologies Method for processing reaction mixtures in parallel
US6890492B1 (en) 1998-08-13 2005-05-10 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US6410332B1 (en) * 1998-09-08 2002-06-25 Symyx Technologies, Inc. Sampling and analysis of reactions by trapping reaction components on a sorbent
EP1113991B1 (en) 1998-09-18 2004-06-09 Symyx Technologies, Inc. Formation of combinatorial arrays of materials using solution-based methodologies
US6535284B1 (en) 1998-10-19 2003-03-18 Symyx Technologies, Inc. Rheo-optical indexer and method of screening and characterizing arrays of materials
KR20010092734A (en) * 1998-11-12 2001-10-26 데이 수잔 자넷 Method and apparatus for screening catalyst libraries
US6569631B1 (en) 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
AU2368900A (en) * 1998-12-18 2000-07-03 Symyx Technologies, Inc. Apparatus and method for characterizing libraries of different materials using x-ray scattering
US7491677B2 (en) 1999-01-15 2009-02-17 Basf Catalysts Llc Combinatorial synthesis
PL349046A1 (en) * 1999-01-22 2002-07-01 Thales Technologies Mass spectrometric screening of catalysts
US6797516B1 (en) * 1999-01-22 2004-09-28 Thales Technologies Ag Mass spectrometric screening of catalysts
US7384387B1 (en) * 1999-02-11 2008-06-10 Maxygen, Inc. High throughput mass spectrometry
US6690464B1 (en) 1999-02-19 2004-02-10 Spectral Dimensions, Inc. High-volume on-line spectroscopic composition testing of manufactured pharmaceutical dosage units
US20020042140A1 (en) * 1999-03-03 2002-04-11 Alfred Hagemeyer Methods for analysis of heterogeneous catalysts in a multi-variable screening reactor
US6749814B1 (en) 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US7150994B2 (en) * 1999-03-03 2006-12-19 Symyx Technologies, Inc. Parallel flow process optimization reactor
WO2000054309A1 (en) * 1999-03-09 2000-09-14 The Scripps Research Institute Improved desorption/ionization of analytes from porous light-absorbing semiconductor
US6855258B2 (en) * 1999-04-02 2005-02-15 Symyx Technologies, Inc. Methods for characterization of polymers using multi-dimensional liquid chromatography with parallel second-dimension sampling
US6351983B1 (en) * 1999-04-12 2002-03-05 The Regents Of The University Of California Portable gas chromatograph mass spectrometer for on-site chemical analyses
DE19918956A1 (en) * 1999-04-27 2000-11-02 Studiengesellschaft Kohle Mbh Process for the automated investigation of catalytic and spectroscopic properties of the components of combinatorial libraries
US6824987B1 (en) * 1999-05-11 2004-11-30 President And Fellows Of Harvard College Small molecule printing
US7932213B2 (en) 1999-05-11 2011-04-26 President And Fellows Of Harvard College Small molecule printing
SE515856C2 (en) * 1999-05-19 2001-10-22 Ericsson Telefon Ab L M Carrier for electronic components
US6468410B1 (en) 1999-06-14 2002-10-22 Eveready Battery Company, Inc. Method for synthesis and characterization of electrode materials
DE60023005T2 (en) * 1999-06-17 2006-07-20 Smiths Detection Inc., Pasadena MULTIPLE SENSOR SYSTEM AND DEVICE
US6572828B1 (en) * 1999-07-16 2003-06-03 General Electric Company Method and apparatus for high-throughput chemical screening
US6408250B1 (en) 1999-08-10 2002-06-18 Battelle Memorial Institute Methods for characterizing, classifying, and identifying unknowns in samples
FR2798659B1 (en) * 1999-09-17 2001-11-16 Bp Chemicals Snc METHOD AND APPARATUS FOR THE DEVELOPMENT OF POLYMERIZATION CATALYSTS
US6311549B1 (en) * 1999-09-23 2001-11-06 U T Battelle Llc Micromechanical transient sensor for measuring viscosity and density of a fluid
JP3413131B2 (en) * 1999-10-04 2003-06-03 キヤノン株式会社 Optical apparatus and device manufacturing method
US7448258B2 (en) * 1999-10-29 2008-11-11 Avery Dennison Corporation High throughput screening for moisture barrier characteristics of materials
US7033840B1 (en) 1999-11-09 2006-04-25 Sri International Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries
AU1476601A (en) * 1999-11-09 2001-06-06 Sri International Array for the high-throughput synthesis, screening and characterization of combinatorial libraries, and methods for making the array
DE19959973A1 (en) * 1999-12-13 2001-06-21 Basf Ag Process for combinatorial production and testing of heterogeneous catalysts
US6291828B1 (en) * 1999-12-21 2001-09-18 Axchlisrtechnologies, Inc. Glass-like insulator for electrically isolating electrodes from ion implanter housing
DE10004816A1 (en) 2000-02-04 2001-08-09 Hte Gmbh Method and device for the combinatorial production and testing of material libraries using photoacoustic analysis methods
ES2166310B1 (en) * 2000-02-08 2003-10-16 Univ Valencia Politecnica AUTOMATIC DIPOSITIVE AND MULTIPLE CATALYTIC TEST METHOD
US6627571B1 (en) * 2000-03-01 2003-09-30 Symyx Technologies, Inc. Method and system for the situ synthesis of a combinatorial library of supported catalyst materials
US6881585B1 (en) 2000-03-06 2005-04-19 General Electric Company Method and apparatus for rapid screening of volatiles
ATE287291T1 (en) 2000-03-07 2005-02-15 Symyx Technologies Inc PROCESS OPTIMIZATION REACTOR WITH PARALLEL FLOW
DE10012962B4 (en) * 2000-03-16 2005-08-04 Peter Prof. Dr. Bäuerle Process for the parallel synthesis of at least two coumarin derivatives and substituted coumarin derivatives and Arylboronsäurepropandiolester
DE10012847A1 (en) 2000-03-16 2001-09-27 Hte Gmbh Combinatorial properties inspection method for building blocks of material libraries, e.g. catalyst, involves measuring different parameters of two building blocks by infrared thermography and mass spectrometry
US7216113B1 (en) * 2000-03-24 2007-05-08 Symyx Technologies, Inc. Remote Execution of Materials Library Designs
US6983233B1 (en) 2000-04-19 2006-01-03 Symyx Technologies, Inc. Combinatorial parameter space experiment design
CA2344946A1 (en) * 2000-05-10 2001-11-10 Symyx Technologies, Inc. Polymer libraries on a substrate, method of forming polymer libraries on a substrate and characterization methods with same
PT1158459E (en) * 2000-05-16 2009-02-02 Sicpa Holding Sa Method, device and security system, all for authenticating a marking
US6562411B2 (en) 2000-05-24 2003-05-13 Agfa-Gevaert Combinatorial coating for developing novel materials
US6393898B1 (en) 2000-05-25 2002-05-28 Symyx Technologies, Inc. High throughput viscometer and method of using same
US6506605B1 (en) 2000-05-26 2003-01-14 Engelhard Corporation System for sensing catalyst coating loss and efficiency
US6664067B1 (en) * 2000-05-26 2003-12-16 Symyx Technologies, Inc. Instrument for high throughput measurement of material physical properties and method of using same
US20050048614A1 (en) * 2000-06-13 2005-03-03 Children's Medical Center Corporation Biosynthetic oncolytic molecules and uses therefor
US7078164B1 (en) 2000-06-19 2006-07-18 Symyx Technologies, Inc. High throughput screen for identifying polymerization catalysts from potential catalysts
US6697454B1 (en) 2000-06-29 2004-02-24 X-Ray Optical Systems, Inc. X-ray analytical techniques applied to combinatorial library screening
DE10031587A1 (en) * 2000-06-29 2002-01-10 Basf Ag Dosing of microscale suspensions for the production of material samples in combinatorial materials research and their testing
US6755364B2 (en) * 2000-07-07 2004-06-29 Symyx Technologies, Inc. Methods and apparatus for mechanical treatment of materials such as catalysts
US7052659B1 (en) 2000-07-18 2006-05-30 General Electric Company Sequential high throughput screening method and system
US7018589B1 (en) 2000-07-19 2006-03-28 Symyx Technologies, Inc. High pressure parallel reactor
US20040224204A1 (en) * 2000-07-19 2004-11-11 Nuvant Systems, Inc. High throughput screening device for combinatorial chemistry
US6558624B1 (en) * 2000-07-25 2003-05-06 General Electric Company Method and analytical system for rapid screening of combinatorial libraries
US6701774B2 (en) * 2000-08-02 2004-03-09 Symyx Technologies, Inc. Parallel gas chromatograph with microdetector array
US6484567B1 (en) 2000-08-03 2002-11-26 Symyx Technologies, Inc. Rheometer for rapidly measuring small quantity samples
GB0019176D0 (en) * 2000-08-05 2000-09-27 Cambridge Material Science Lim Monitoring thermal events
US6647342B2 (en) * 2000-08-07 2003-11-11 Novodynamics, Inc. Knowledge-based process for the development of materials
WO2002016927A2 (en) * 2000-08-24 2002-02-28 Newton Scientific, Inc. Sample introduction interface for analytical processing
DE10043323A1 (en) * 2000-08-28 2002-03-28 Cybio Ag Selectively heatable substance carrier
US6864091B1 (en) * 2000-08-31 2005-03-08 Symyx Technologies, Inc. Sampling probe
JP2002095272A (en) * 2000-09-11 2002-03-29 Minolta Co Ltd Driver
US6780648B1 (en) 2000-09-20 2004-08-24 General Electric Company Method and system for selectively distributing luminescence material precursors
US6746104B2 (en) 2000-09-25 2004-06-08 Picoliter Inc. Method for generating molecular arrays on porous surfaces
US6612686B2 (en) 2000-09-25 2003-09-02 Picoliter Inc. Focused acoustic energy in the preparation and screening of combinatorial libraries
US6808934B2 (en) 2000-09-25 2004-10-26 Picoliter Inc. High-throughput biomolecular crystallization and biomolecular crystal screening
US6666541B2 (en) * 2000-09-25 2003-12-23 Picoliter Inc. Acoustic ejection of fluids from a plurality of reservoirs
US7348182B2 (en) * 2000-10-03 2008-03-25 Mirari Biosciences, Inc. Directed microwave chemistry
AU2002211317A1 (en) * 2000-10-03 2002-04-15 Mirari Biosciences, Inc. Methods and compositions for directed microwave chemistry
US20040209303A1 (en) 2000-10-03 2004-10-21 Martin Mark T. Methods and compositions for directed microwave chemistry
US6541264B1 (en) 2000-10-19 2003-04-01 General Electric Company Aromatic polycarbonate characterization
DE10052511B4 (en) * 2000-10-23 2005-12-29 Henkel Kgaa System for monitoring chemical reactions and its use
DE10052631C1 (en) * 2000-10-24 2002-04-04 Bosch Gmbh Robert Testing device for piezo active material uses application of electric and/or magnetic field with detection of temperature variation
US6482264B1 (en) * 2000-10-26 2002-11-19 General Electric Company Systems and methods for fabrication of coating libraries
US20020132360A1 (en) * 2000-11-17 2002-09-19 Flir Systems Boston, Inc. Apparatus and methods for infrared calorimetric measurements
WO2002061858A2 (en) * 2000-11-17 2002-08-08 Thermogenic Imaging, Inc. Apparatus and methods for infrared calorimetric measurements
US20040110301A1 (en) * 2000-11-17 2004-06-10 Neilson Andy C Apparatus and methods for measuring reaction byproducts
DE10059890A1 (en) * 2000-12-01 2002-06-20 Hte Ag Method for producing a large number of building blocks of a material library
US20020106788A1 (en) * 2000-12-04 2002-08-08 Cawse James Norman Permeable reactor plate and method
US6596239B2 (en) * 2000-12-12 2003-07-22 Edc Biosystems, Inc. Acoustically mediated fluid transfer methods and uses thereof
US20020074517A1 (en) * 2000-12-15 2002-06-20 Andrew Krutchinsky High capacity and scanning speed system for sample handling and analysis
EP1350214A4 (en) * 2000-12-15 2009-06-10 Symyx Technologies Inc Methods and apparatus for designing high-dimensional combinatorial experiments
DE10064317A1 (en) * 2000-12-22 2002-10-17 Studiengesellschaft Kohle Mbh New photocatalysts and methods for their discovery
US7085773B2 (en) 2001-01-05 2006-08-01 Symyx Technologies, Inc. Laboratory database system and methods for combinatorial materials research
US6406916B1 (en) 2001-01-22 2002-06-18 General Electric Company Method and apparatus for rapid quantitation of a dihydric phenol
US7015047B2 (en) * 2001-01-26 2006-03-21 Aviva Biosciences Corporation Microdevices having a preferential axis of magnetization and uses thereof
US7118917B2 (en) 2001-03-07 2006-10-10 Symyx Technologies, Inc. Parallel flow reactor having improved thermal control
US20020137106A1 (en) * 2001-03-09 2002-09-26 Ciphergen Biosystems, Inc. Detection of biological pathway components
US20020176927A1 (en) * 2001-03-29 2002-11-28 Kodas Toivo T. Combinatorial synthesis of material systems
US6383815B1 (en) 2001-04-04 2002-05-07 General Electric Company Devices and methods for measurements of barrier properties of coating arrays
US6567753B2 (en) 2001-04-04 2003-05-20 General Electric Company Devices and methods for simultaneous measurement of transmission of vapors through a plurality of sheet materials
US6686201B2 (en) 2001-04-04 2004-02-03 General Electric Company Chemically-resistant sensor devices, and systems and methods for using same
US20020172620A1 (en) * 2001-04-04 2002-11-21 Potyrailo Radislav Alexandrovich Systems and methods for rapid evaluation of chemical resistance of materials
US6692708B2 (en) * 2001-04-05 2004-02-17 Symyx Technologies, Inc. Parallel reactor for sampling and conducting in situ flow-through reactions and a method of using same
DE10117275B4 (en) 2001-04-06 2005-02-24 Hte Ag The High Throughput Experimentation Company Device for archiving and analyzing materials
US7572642B2 (en) * 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
US6808928B1 (en) 2001-04-27 2004-10-26 Uop Llc Desorptive method for determining a surface property of a solid
US6844198B2 (en) 2001-04-27 2005-01-18 Uop Llc Adsorptive method for determining a surface property of a solid
GB2392980B (en) * 2001-05-15 2005-06-15 Baker Hughes Inc Method and apparatus for downhole fluid characterization using flxural mechanical resonators
US7162918B2 (en) * 2001-05-15 2007-01-16 Baker Hughes Incorporated Method and apparatus for downhole fluid characterization using flexural mechanical resonators
US7317989B2 (en) * 2001-05-15 2008-01-08 Baker Hughes Incorporated Method and apparatus for chemometric estimations of fluid density, viscosity, dielectric constant, and resistivity from mechanical resonator data
US7858385B2 (en) 2001-05-16 2010-12-28 Los Alamos National Security, Llc Method for detecting binding events using micro-X-ray fluorescence spectrometry
DE10125258A1 (en) * 2001-05-23 2003-01-09 November Ag Molekulare Medizin Method for determining the binding behavior of ligands that specifically bind to target molecules
US6563117B2 (en) * 2001-06-02 2003-05-13 Ilya Feygin Article comprising IR-reflective multi-well plates
US7302830B2 (en) * 2001-06-06 2007-12-04 Symyx Technologies, Inc. Flow detectors having mechanical oscillators, and use thereof in flow characterization systems
US20030003021A1 (en) * 2001-06-06 2003-01-02 Monsanto Technology Llc Parallel reactor system and method
US20030005771A1 (en) * 2001-06-07 2003-01-09 Gokhan Percin Two-dimensional array of ultrasonic sensors for high throughput fluid screening
US6813958B2 (en) 2001-06-21 2004-11-09 The United States Of America As Represented By The Secretary Of Commerce Method for combinatorially measuring adhesion strength
US20030068829A1 (en) * 2001-06-25 2003-04-10 Symyx Technologies, Inc. High throughput crystallographic screening of materials
US6838052B2 (en) 2001-06-29 2005-01-04 Symyx Technologies, Inc. In-situ injection and materials screening device
US6923939B1 (en) * 2001-07-05 2005-08-02 Uop Llc Heat activated membrane introduction apparatus and method for screening materials
US7354710B2 (en) * 2001-07-11 2008-04-08 Genomics Usa, Inc. Methods and devices based upon a novel form of nucleic acid duplex on a surface
US10272409B2 (en) 2001-07-11 2019-04-30 Michael E. Hogan Methods and devices based upon a novel form of nucleic acid duplex on a surface
WO2003014732A1 (en) * 2001-08-10 2003-02-20 Symyx Technologies, Inc. Apparatuses and methods for creating and testing pre-formulations and systems for same
JP2005500530A (en) * 2001-08-17 2005-01-06 ユニバーシティ オブ ペンシルベニア−センター フォー テクノロジー トランスファー How to prepare and store samples for bioreaction chips
US6837115B2 (en) * 2001-08-24 2005-01-04 Symyx Technologies, Inc. High throughput mechanical rapid serial property testing of materials libraries
US6860148B2 (en) 2001-08-24 2005-03-01 Symyx Technologies, Inc. High throughput fabric handle screening
US6736017B2 (en) 2001-08-24 2004-05-18 Symyx Technologies, Inc. High throughput mechanical rapid serial property testing of materials libraries
US6690179B2 (en) * 2001-08-24 2004-02-10 Symyx Technologies, Inc. High throughput mechanical property testing of materials libraries using capacitance
US6650102B2 (en) 2001-08-24 2003-11-18 Symyx Technologies, Inc. High throughput mechanical property testing of materials libraries using a piezoelectric
US6857309B2 (en) 2001-08-24 2005-02-22 Symyx Technologies, Inc. High throughput mechanical rapid serial property testing of materials libraries
US6772642B2 (en) 2001-08-24 2004-08-10 Damian A. Hajduk High throughput mechanical property and bulge testing of materials libraries
WO2003019150A1 (en) * 2001-08-24 2003-03-06 Symyx Technologies, Inc. High throughput mechanical property testing of materials libraries using fluid, voltage, and piezoelectric
US6769292B2 (en) * 2001-08-24 2004-08-03 Symyx Technologies, Inc High throughput rheological testing of materials
WO2003021251A1 (en) * 2001-08-28 2003-03-13 Symyx Technologies, Inc. Methods for characterization of polymers using multi-dimentional liquid chromatography
US20030055587A1 (en) * 2001-09-17 2003-03-20 Symyx Technologies, Inc. Rapid throughput surface topographical analysis
TWI251584B (en) * 2001-10-17 2006-03-21 Ind Tech Res Inst Triangular combinatorial chemchip and its preparation
US6689218B2 (en) * 2001-10-23 2004-02-10 General Electric Company Systems for the deposition and curing of coating compositions
US6544334B1 (en) 2001-10-23 2003-04-08 General Electric Company Systems and methods for the deposition and curing of coating compositions
US7148683B2 (en) 2001-10-25 2006-12-12 Intematix Corporation Detection with evanescent wave probe
US6873415B2 (en) * 2001-11-13 2005-03-29 Battelle Memorial Institute Photoacoustic spectroscopy sample array vessel and photoacoustic spectroscopy method for using the same
US6999174B2 (en) * 2001-11-13 2006-02-14 Battelle Memorial Institute Photoacoustic spectroscopy sample array vessels and photoacoustic spectroscopy methods for using the same
US6870626B2 (en) * 2001-11-13 2005-03-22 Battelle Memorial Institute Array-based photoacoustic spectroscopy
WO2003044509A1 (en) * 2001-11-19 2003-05-30 The Circle For The Promotion Of Science And Engineering Method for thermal analysis and system for thermal analysis
US6860855B2 (en) * 2001-11-19 2005-03-01 Advanced Imaging Technologies, Inc. System and method for tissue biopsy using ultrasonic imaging
US6816536B2 (en) * 2001-11-30 2004-11-09 Spectra Physics, Inc. Method and apparatus for in situ protection of sensitive optical materials
US6881363B2 (en) 2001-12-07 2005-04-19 Symyx Technologies, Inc. High throughput preparation and analysis of materials
WO2003056604A1 (en) * 2001-12-21 2003-07-10 Mds Inc., Doing Business As Mds Sciex Use of notched broadband waveforms in a linear ion trap
US6671631B2 (en) 2002-01-04 2003-12-30 General Electric Company Systems and methods for analyzing viscoelastic properties of combinatorial libraries of materials
ES2209588B1 (en) * 2002-01-14 2005-04-01 Universidad Politecnica De Valencia FLOW CONTROL SYSTEM FOR MULTIPLE TESTS OF SOLID MATERIALS AND DEVICE FOR MULTIPLE CATALYTIC TESTS UNDERSTANDING THE SYSTEM.
US7013709B2 (en) * 2002-01-31 2006-03-21 Symyx Technologies, Inc. High throughput preparation and analysis of plastically shaped material samples
US20030154031A1 (en) * 2002-02-14 2003-08-14 General Electric Company Method and apparatus for the rapid evaluation of a plurality of materials or samples
US7033542B2 (en) * 2002-02-14 2006-04-25 Archibald William B High throughput screening with parallel vibrational spectroscopy
US6684683B2 (en) * 2002-02-27 2004-02-03 General Electric Company Method and apparatus for characterizing the barrier properties of members of combinatorial libraries
AU2002245700A1 (en) * 2002-03-19 2003-10-08 X-Ray Optical Systems, Inc. Screening of combinatorial library using x-ray analysis
US6949267B2 (en) 2002-04-08 2005-09-27 Engelhard Corporation Combinatorial synthesis
US20030203500A1 (en) * 2002-04-26 2003-10-30 Symyx Technologies, Inc. High throughput testing of fluid samples using an electric field
US7122159B2 (en) 2002-04-29 2006-10-17 Symyx Technologies, Inc. High pressure parallel reactor with individually sealable vessels
GB0210237D0 (en) * 2002-05-03 2002-06-12 Bp Chem Int Ltd Injector system
CA2476286C (en) * 2002-05-07 2008-03-18 Japan Science And Technology Agency Method of recovering micromaterial and device
US20030219456A1 (en) * 2002-05-21 2003-11-27 Taing Ok Method of utilization of zygosaccharomyces rouxii
US6928877B2 (en) * 2002-05-24 2005-08-16 Symyx Technologies, Inc. High throughput microbalance and methods of using same
US6932097B2 (en) 2002-06-18 2005-08-23 Picoliter Inc. Acoustic control of the composition and/or volume of fluid in a reservoir
US20050171304A1 (en) * 2002-06-04 2005-08-04 Peter Chen Method for quantitative characterization of polymerization catalyst performance
DE10225994B3 (en) * 2002-06-12 2004-03-11 Robert Bosch Gmbh Device and method for testing numerous, different material samples
AU2003256276A1 (en) * 2002-06-18 2003-12-31 Picoliter Inc. Acoustic assessment and/or control of fluid content in a reservoir
US20040002162A1 (en) * 2002-06-27 2004-01-01 Leugers Mary Anne Transmission infrared spectroscopy array and method
US20050185175A1 (en) * 2002-07-16 2005-08-25 Canos Avelino C. Rotary support and apparatus used for the multiple spectroscopic characterisation of samples of solid materials
EP1527334A1 (en) * 2002-08-06 2005-05-04 SSCI, Inc. Method of comparing x-ray diffraction patterns using the fundamental parameter method
US7247346B1 (en) 2002-08-28 2007-07-24 Nanosolar, Inc. Combinatorial fabrication and high-throughput screening of optoelectronic devices
CA2399472A1 (en) * 2002-09-06 2004-03-06 Karine Lapointe Printing media evaluation method
TWI308214B (en) * 2002-09-10 2009-04-01 Univ Nat Central Method of forming a biochip and application thereof
US20040123650A1 (en) * 2002-09-17 2004-07-01 Symyx Technologies, Inc. High throughput rheological testing of materials
US7135288B2 (en) * 2002-09-27 2006-11-14 Ut-Battelle, Llc Combinatorial synthesis of ceramic materials
US6865198B2 (en) 2002-09-27 2005-03-08 Battelle Memorial Institute Cavity ringdown spectroscopy system and method
AU2003282936A1 (en) * 2002-10-18 2004-05-04 Symyx Technologies, Inc. Environmental control system fluid sensing system and method comprising a sesnsor with a mechanical resonator
US7112443B2 (en) * 2002-10-18 2006-09-26 Symyx Technologies, Inc. High throughput permeability testing of materials libraries
US6873916B2 (en) * 2002-10-18 2005-03-29 Symyx Technologies, Inc. Application specific integrated circuitry for controlling analysis of a fluid
US7043969B2 (en) 2002-10-18 2006-05-16 Symyx Technologies, Inc. Machine fluid sensor and method
WO2004037869A2 (en) * 2002-10-25 2004-05-06 Exxonmobil Chemical Patents Inc. Late transition metal catalysts for olefin oligomerizations
AU2003284175A1 (en) * 2002-10-28 2004-05-25 Biomondex, Ltd. Acoustic array analytical system
CA2410927A1 (en) * 2002-11-05 2004-05-05 Michel Petitclerc Electrically heated reactor for reforming in gaseous phase
US20040107986A1 (en) * 2002-12-06 2004-06-10 Neilson Andy C. High throughput microcalorimeter systems and methods
US7172730B2 (en) * 2002-12-09 2007-02-06 Hewlett-Packard Development Company, L.P. Thermal sensor
US9854985B2 (en) * 2002-12-09 2018-01-02 Bio-Signal Group Corp. Brain signal telemetry and seizure prediction
WO2004058396A2 (en) 2002-12-20 2004-07-15 Honda Giken Kogyo Kabushiki Kaisha Methods for the preparation of catalysts for hydrogen generation
US7160513B2 (en) 2002-12-20 2007-01-09 Symyx Technologies, Inc. Batch reactor with injection system
US7390664B2 (en) * 2002-12-20 2008-06-24 Exxonmobil Research And Engineering Company Method and apparatus for high throughput catalysts screening and optimization
US20060246593A1 (en) * 2003-01-03 2006-11-02 Towler Gavin P Material processing apparatus and method
WO2004065618A2 (en) * 2003-01-16 2004-08-05 Thermogenic Imaging Methods and devices for monitoring cellular metabolism in microfluidic cell-retaining chambers
US7213034B2 (en) * 2003-01-24 2007-05-01 Symyx Technologies, Inc. User-configurable generic experiment class for combinatorial materials research
US7579194B2 (en) * 2003-01-30 2009-08-25 Techelan, Llc Apparatus and method for investigating chemical entities
US7521257B2 (en) * 2003-02-11 2009-04-21 The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Reno Chemical sensor with oscillating cantilevered probe and mechanical stop
JP2004271346A (en) * 2003-03-10 2004-09-30 Fuji Photo Film Co Ltd Assay method and assay device utilizing unit for biochemical analysis
US7260980B2 (en) 2003-03-11 2007-08-28 Adams Jesse D Liquid cell and passivated probe for atomic force microscopy and chemical sensing
US6861647B2 (en) * 2003-03-17 2005-03-01 Indiana University Research And Technology Corporation Method and apparatus for mass spectrometric analysis of samples
EP1517140A3 (en) * 2003-03-19 2005-04-06 TF Instruments GmbH Method and device for diagnostic investigation of biological samples
US7721590B2 (en) 2003-03-21 2010-05-25 MEAS France Resonator sensor assembly
US7158897B2 (en) * 2003-03-21 2007-01-02 Symyx Technologies, Inc. Integrated circuitry for controlling analysis of a fluid
WO2004086027A2 (en) * 2003-03-21 2004-10-07 Symyx Technologies, Inc. Mechanical resonator
US20040250622A1 (en) * 2003-03-21 2004-12-16 Symyx Technologies, Inc. Resonator sensor assembly
IL155955A0 (en) * 2003-05-15 2003-12-23 Widemed Ltd Adaptive prediction of changes of physiological/pathological states using processing of biomedical signal
US7465661B2 (en) * 2003-05-28 2008-12-16 The United States Of America As Represented By The Secretary Of The Navy High aspect ratio microelectrode arrays
WO2004109254A2 (en) * 2003-06-06 2004-12-16 Ionwerks Fullerene-based maldi matrices for peptides and proteins
DE10325735B4 (en) * 2003-06-06 2006-06-29 Robert Bosch Gmbh Apparatus and method for analyzing a material library
US7294367B2 (en) * 2003-06-06 2007-11-13 The United States Of America As Represented By The Secretary Of The Navy Biological laser printing via indirect photon-biomaterial interactions
US6805175B1 (en) 2003-06-12 2004-10-19 Symyx Technologies, Inc. Powder transfer method and apparatus
US7134459B2 (en) * 2003-06-12 2006-11-14 Symyx Technologies, Inc. Methods and apparatus for mixing powdered samples
US7350402B2 (en) * 2003-07-21 2008-04-01 Aria Analytics, Inc. Method and apparatus for determination of medical diagnostics utilizing biological fluids
US7350403B2 (en) * 2003-07-21 2008-04-01 Aria Analyties, Inc. Method and apparatus for determination of food quality and authenticity
WO2005017502A1 (en) 2003-07-28 2005-02-24 Symyx Technologies, Inc. Parallel infrared spectroscopy apparatus and method
ES2223296B1 (en) * 2003-08-01 2005-12-16 Universidad Politecnica De Valencia AN APPLIANCE FOR THE SIMULTANEOUS OR CONSECUTIVE CHARACTERIZATION OF MULTIPLE SAMPLES OF SOLID MATERIALS BY PHOTOLUMINISCENCE.
DE10335968A1 (en) * 2003-08-06 2005-02-24 Basf Ag Sequential production of a library of solids (especially heterogeneous catalysts) comprises dosing solutions, emulsions and/or dispersions into a mixer and drying, with variations and repetition
US20050037499A1 (en) * 2003-08-11 2005-02-17 Symyx Technologies, Inc. Apparatus and method for determining temperatures at which properties of materials change
US20050054116A1 (en) * 2003-09-05 2005-03-10 Potyrailo Radislav A. Method of manufacturing and evaluating sensor coatings and the sensors derived therefrom
US7276351B2 (en) * 2003-09-10 2007-10-02 Seahorse Bioscience Method and device for measuring multiple physiological properties of cells
DE10346769A1 (en) * 2003-10-06 2005-04-21 Zimmer Ag Automatic analyzer and method for monitoring polymer production by mass spectrometry
DE10346768A1 (en) 2003-10-06 2005-04-21 Zimmer Ag Method for automatic analysis of polymer-containing waste and automatic analyzer for this purpose
US8658349B2 (en) * 2006-07-13 2014-02-25 Seahorse Bioscience Cell analysis apparatus and method
US20060257286A1 (en) * 2003-10-17 2006-11-16 Adams Jesse D Self-sensing array of microcantilevers for chemical detection
US20070087401A1 (en) * 2003-10-17 2007-04-19 Andy Neilson Analysis of metabolic activity in cells using extracellular flux rate measurements
EP1526364B2 (en) * 2003-10-21 2009-09-30 Mettler-Toledo AG Method for operating a weighing device and weighing device
US20050087017A1 (en) * 2003-10-27 2005-04-28 Blake Robert A. Apparatus and method for inspecting grinding wheels
US7337672B2 (en) * 2003-10-27 2008-03-04 Alcoa Inc. Method for inspecting grinding wheels
US7150182B2 (en) * 2003-10-31 2006-12-19 Chevron Oronite Company, Llc High throughput screening methods for lubricating oil compositions
JP4729856B2 (en) * 2003-10-31 2011-07-20 Tdk株式会社 Method for measuring relative permittivity of dielectric material of powder
US20050095717A1 (en) * 2003-10-31 2005-05-05 Wollenberg Robert H. High throughput screening methods for lubricating oil compositions
US7069203B2 (en) * 2003-10-31 2006-06-27 Chevron Oronite Company Llc Method and system of product development process for chemical compositions using high volume modeling
US20050095714A1 (en) 2003-10-31 2005-05-05 Wollenberg Robert H. High throughput preparation of lubricating oil compositions for combinatorial libraries
US7579192B2 (en) * 2003-10-31 2009-08-25 Chevron Oronite Company Llc High throughput screening methods for lubricating oil compositions
US7462490B2 (en) 2003-10-31 2008-12-09 Chevron Oronite Company Llc Combinatorial lubricating oil composition libraries
US7378337B2 (en) * 2003-11-04 2008-05-27 Electro Scientific Industries, Inc. Laser-based termination of miniature passive electronic components
US20090288479A1 (en) * 2003-11-17 2009-11-26 Woody Shane C Standing wave fluidic and biological tools
GB0328054D0 (en) * 2003-12-04 2004-01-07 Council Cent Lab Res Councils Fluid probe
WO2005059779A2 (en) * 2003-12-16 2005-06-30 Symyx Technologies, Inc. Indexing scheme for formulation workflows
US20050182566A1 (en) * 2004-01-14 2005-08-18 Baker Hughes Incorporated Method and apparatus for determining filtrate contamination from density measurements
US7985592B2 (en) * 2004-02-13 2011-07-26 Chevron Oronite Company Llc High throughput screening methods for lubricating oil compositions
US7137289B2 (en) * 2004-02-13 2006-11-21 Chevron Oronite Company, Llc High throughput screening methods for lubricating oil compositions
US8249816B2 (en) * 2004-02-13 2012-08-21 Chevron Oronite Company, Llc High throughput screening methods for fuel compositions
US7306948B2 (en) * 2004-02-13 2007-12-11 Chevron Oronite Company Llc High throughput screening methods for lubricating oil compositions
DE102004017039A1 (en) * 2004-04-02 2005-11-03 Rwth Aachen Method and device for detecting process parameters of reaction liquids in a plurality of shaken microreactors
US7427506B2 (en) * 2004-04-13 2008-09-23 Exxonmobil Chemical Patents Inc. High throughput property testing of olefin copolymers using rheological determinations
CN101001944A (en) * 2004-04-14 2007-07-18 催化剂设计有限公司 Smart combinatorial operando spectroscopy catalytic system
WO2005103674A2 (en) 2004-04-21 2005-11-03 Symyx Technologies, Inc. Portable fluid sensing system and sensing method using a flexural resonator
US7553670B2 (en) * 2004-04-28 2009-06-30 3M Innovative Properties Company Method for monitoring a polymerization in a three-dimensional sample
US20050247673A1 (en) * 2004-05-07 2005-11-10 International Business Machines Corporation Confinement of fluids on surfaces
UA79247C2 (en) * 2004-06-01 2007-06-11 Volodymyr Mykhailovyc Voloshyn Method and device (variants) of separation of raw material by lumps
CN100583434C (en) 2004-06-07 2010-01-20 先锋生物科技股份有限公司 Optical lens system and method for microfluidic devices
US8273579B2 (en) * 2004-06-08 2012-09-25 Bizpac (Australia) Pty. Ltd. Method and apparatus for inspecting biological samples
US7878064B2 (en) * 2004-06-12 2011-02-01 Akubio Limited Analytical apparatus with array of sensors and calibrating element
JP2008503602A (en) 2004-06-16 2008-02-07 ダウ グローバル テクノロジーズ インコーポレイティド Apparatus and method for Ziegler-Natta research
CN102321201B (en) 2004-06-16 2013-06-26 陶氏环球技术有限责任公司 Method for selecting polymerization modifiers
US7683003B2 (en) 2004-06-16 2010-03-23 Dow Global Technologies, Inc. Method for identifying Ziegler-Natta cocatalysts
FR2872910B1 (en) * 2004-07-07 2006-10-13 Nanoraptor Sa OPTICAL COMPONENT FOR OBSERVING A NANOMETRIC SAMPLE, SYSTEM COMPRISING SUCH A COMPONENT, ANALYSIS METHOD USING THE SAME, AND APPLICATIONS THEREOF
US7507337B2 (en) * 2004-09-03 2009-03-24 Symyx Technologies, Inc. System and method for rapid chromatography with fluid temperature and mobile phase composition control
US7597852B2 (en) * 2004-09-03 2009-10-06 Symyx Solutions, Inc. Substrate for sample analyses
NZ553527A (en) 2004-09-15 2009-12-24 Bp Oil Int Process for evaluating a refinery feedstock
US20060292846A1 (en) * 2004-09-17 2006-12-28 Pinto Gustavo A Material management in substrate processing
GB2437753B8 (en) 2004-10-01 2009-05-20 Nevada System Of Higher Education Cantilevered probe detector with piezoelectric element
US7211793B2 (en) 2004-11-09 2007-05-01 Cummins, Inc Mass spectrometry system and method
GB0427450D0 (en) 2004-12-15 2005-01-19 Bp Oil Int Process
US7194902B1 (en) 2004-12-23 2007-03-27 Schlumberger Technology Corporation Apparatus and method for formation evaluation
US7222671B2 (en) * 2004-12-23 2007-05-29 Schlumberger Technology Corporation Apparatus and method for formation evaluation
GB0501102D0 (en) 2005-01-19 2005-02-23 Bp Chem Int Ltd Process
WO2006084263A2 (en) * 2005-02-04 2006-08-10 Visyx Technologies, Inc. Multi-position fluid resonator sensors and methods
EP1877768A2 (en) * 2005-04-01 2008-01-16 Visyx Technologies Inc. Monitoring by means of an on-line sensor and fluidic operations involving unit separation and reaction operations
US7291850B2 (en) * 2005-04-08 2007-11-06 Asml Netherlands B.V. Lithographic apparatus and device manufacturing method
US8943163B2 (en) * 2005-05-02 2015-01-27 S-Matrix System for automating scientific and engineering experimentation
US7239966B2 (en) * 2005-05-12 2007-07-03 S-Matrix System for automating scientific and engineering experimentation
US7263874B2 (en) * 2005-06-08 2007-09-04 Bioscale, Inc. Methods and apparatus for determining properties of a fluid
US7634937B2 (en) * 2005-07-01 2009-12-22 Symyx Solutions, Inc. Systems and methods for monitoring solids using mechanical resonator
WO2007022110A2 (en) * 2005-08-12 2007-02-22 Symyx Technologies, Inc. Event-based library process design
US7613574B2 (en) 2005-10-28 2009-11-03 S-Matrix System and method for automating scientific and engineering experimentation for deriving surrogate response data
US8209149B2 (en) 2005-10-28 2012-06-26 S-Matrix System and method for automatically creating data sets for complex data via a response data handler
US7606685B2 (en) * 2006-05-15 2009-10-20 S-Matrix Method and system that optimizes mean process performance and process robustness
US20070105125A1 (en) * 2005-11-08 2007-05-10 Tsai George P Chemical array housing having a gas delivery element and methods of using the same
JP2009522576A (en) * 2006-01-03 2009-06-11 プレジデント アンド フェローズ オブ ハーバード カレッジ Small molecule printing
US7700913B2 (en) 2006-03-03 2010-04-20 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US8026477B2 (en) 2006-03-03 2011-09-27 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
GB0605273D0 (en) * 2006-03-16 2006-04-26 Council Cent Lab Res Councils Fluid robe
US7369242B2 (en) * 2006-03-17 2008-05-06 Honeywell International Inc. Cavity ring-down spectrometer for semiconductor processing
US7634157B1 (en) * 2006-03-23 2009-12-15 Flir Systems, Inc. Infrared and near-infrared camera hyperframing
US20070269611A1 (en) * 2006-03-31 2007-11-22 Intematix Corporation Systems and methods of combinatorial synthesis
US20070238132A1 (en) * 2006-04-04 2007-10-11 Intematix Corporation Screening of combinatorial libraries using radioactivity
EP2035122A4 (en) * 2006-05-26 2010-05-05 Ionsense Inc Flexible open tube sampling system for use with surface ionization technology
US7403643B2 (en) * 2006-08-11 2008-07-22 Fotonation Vision Limited Real-time face tracking in a digital image acquisition device
US20080113877A1 (en) * 2006-08-16 2008-05-15 Intematix Corporation Liquid solution deposition of composition gradient materials
US20100164513A1 (en) * 2006-08-21 2010-07-01 Uri Rapoport non-destructive on-line method for measuring predetermined physical, electrochemical, chemical or biological state transformation of a substance and a system thereof
US9494540B2 (en) 2006-08-21 2016-11-15 Aspect Ai Ltd. System and method for a nondestructive on-line testing of samples
WO2008046111A2 (en) * 2006-10-13 2008-04-17 Ionsense, Inc. A sampling system for containment and transfer of ions into a spectroscopy system
US8440965B2 (en) 2006-10-13 2013-05-14 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US20090100925A1 (en) * 2006-10-27 2009-04-23 Baker Hughes Incorporated System and method for coating flexural mechanical resonators
EP2097745B1 (en) 2006-12-28 2012-12-19 Highland Biosciences Limited Biosensor
EP1950550A1 (en) * 2007-01-25 2008-07-30 Flamac Method and apparatus for measuring viscosity and surface tension
DE102007005618A1 (en) * 2007-01-31 2008-08-07 Institut für Automation und Kommunikation (ifak) e. V. Magdeburg Device and method for determining the amount of substance in small cavities
WO2008140874A1 (en) * 2007-05-09 2008-11-20 Dow Global Technologies Inc. System and method for high-throughput turbidity measurements
US7807109B2 (en) 2007-05-14 2010-10-05 Freeslate, Inc. Parallel batch reactor with pressure monitoring
US7655191B2 (en) 2007-05-14 2010-02-02 Symyx Solutions, Inc. Methods for chemical reactions in a parallel batch reactor
US8219328B2 (en) 2007-05-18 2012-07-10 S-Matrix System and method for automating scientific and engineering experimentation for deriving surrogate response data
DE102007031680A1 (en) * 2007-07-06 2009-01-08 Thermo Fisher Scientific (Bremen) Gmbh Apparatus for providing gases, in particular for the isotope ratio analysis
EP2019307B1 (en) * 2007-07-24 2018-10-03 Axetris AG Method and gas sensor for performing quartz-enhanced photoacoustic spectroscopy
US20090046535A1 (en) 2007-07-25 2009-02-19 Carlson Eric D Systems and methods for mixing materials
IL185130A0 (en) 2007-08-08 2008-01-06 Semi Conductor Devices An Elbi Thermal based system and method for detecting counterfeit drugs
GB0716202D0 (en) 2007-08-11 2007-09-26 Microvisk Ltd Improved fluid probe
GB0716542D0 (en) * 2007-08-24 2007-10-03 Highland Biosciences Ltd Endotoxin biosensor
US8304714B2 (en) * 2007-11-01 2012-11-06 Baker Hughes Incorporated Chemical sensor using four wave mixing technique
NO329603B1 (en) * 2007-11-22 2010-11-22 Integrated Optoelectronics As Method and system for painting and determining / recognizing different materials
US8044346B2 (en) * 2007-12-21 2011-10-25 Licentia Oy Method and system for desorbing and ionizing chemical compounds from surfaces
US20090262332A1 (en) * 2008-04-18 2009-10-22 Microvast, Inc. High-throughput spectral imaging and spectroscopy apparatus and methods
CN102016600B (en) * 2008-04-23 2013-11-20 通用电气健康护理生物科学股份公司 Positioning of dispensing means in fraction collector
TWI385828B (en) * 2008-09-16 2013-02-11 Chen Hsu Semiconductor light-emitting device with light-modulating function and method of fabricating the same
US8202702B2 (en) * 2008-10-14 2012-06-19 Seahorse Bioscience Method and device for measuring extracellular acidification and oxygen consumption rate with higher precision
US8365575B2 (en) * 2008-11-06 2013-02-05 Bae Systems Information And Electronic Systems Integration Inc. Chemically modified organic CDC based rapid analysis system
US20100127022A1 (en) * 2008-11-21 2010-05-27 Symyx Technologies, Inc. Dispensing valve
EP2508882B1 (en) 2009-02-05 2016-09-21 D.I.R. Technologies (Detection Ir) Ltd. Method and system for determining the quality of pharmaceutical products
US8158936B2 (en) 2009-02-12 2012-04-17 Ibis Biosciences, Inc. Ionization probe assemblies
DE102009015746B4 (en) * 2009-03-31 2011-09-29 Globalfoundries Dresden Module One Limited Liability Company & Co. Kg Method and system for material characterization in semiconductor positioning processes based on FTIR with variable angle of incidence
US8207497B2 (en) 2009-05-08 2012-06-26 Ionsense, Inc. Sampling of confined spaces
WO2011035147A2 (en) * 2009-09-18 2011-03-24 Delaware Capital Formation, Inc. Controlled compressional wave components of thickness shear mode multi-measurand sensors
US8823802B2 (en) * 2009-10-15 2014-09-02 University Of South Carolina Multi-mode imaging in the thermal infrared for chemical contrast enhancement
US8878548B2 (en) 2010-06-11 2014-11-04 Baker Hughes Incorporated Method for treating and sealing piezoelectric tuning forks
DE102010030758B4 (en) * 2010-06-30 2018-07-19 Globalfoundries Dresden Module One Limited Liability Company & Co. Kg Control critical dimensions in optical imaging processes for semiconductor fabrication by extracting aberrations based on imaging plant-specific intensity measurements and simulations
ES2749877T3 (en) * 2010-11-29 2020-03-24 Air Prod & Chem Method and apparatus for measuring the molecular weight of a gas
US8822949B2 (en) 2011-02-05 2014-09-02 Ionsense Inc. Apparatus and method for thermal assisted desorption ionization systems
EP2503322B1 (en) * 2011-03-25 2016-03-09 Detlev Gertitschke Device for inspecting small pharmaceutical products
US8901488B1 (en) 2011-04-18 2014-12-02 Ionsense, Inc. Robust, rapid, secure sample manipulation before during and after ionization for a spectroscopy system
US9240311B2 (en) 2011-06-03 2016-01-19 Perkinelmer Health Sciences, Inc. Apparatus for analysis of sample chemical species featuring multiple sample placement locations
JP2014521106A (en) 2011-07-21 2014-08-25 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク How to collect and process electron diffraction data
RU2488102C1 (en) * 2012-02-21 2013-07-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Вологодский государственный технический университет" (ВоГТУ) Method of determining thermal conductivity of solid body by active method of heat non-destructive testing
US9562880B1 (en) 2012-03-28 2017-02-07 Catalytic Combustion Corporation Monolith catalyst test system and method for its use
US9068954B1 (en) * 2012-03-28 2015-06-30 Catalytic Combustion Corporation Monolith catalyst test system and method for its use
EP2850403B1 (en) 2012-05-18 2021-10-27 Rebellion Photonics, Inc. Divided-aperture infra-red spectral imaging system for chemical detection
US9599508B2 (en) 2012-05-18 2017-03-21 Rebellion Photonics, Inc. Divided-aperture infra-red spectral imaging system
US11163983B2 (en) 2012-09-07 2021-11-02 Stone Lock Global, Inc. Methods and apparatus for aligning sampling points of facial profiles of users
US11017213B1 (en) 2012-09-07 2021-05-25 Stone Lock Global, Inc. Methods and apparatus for biometric verification
US11017211B1 (en) 2012-09-07 2021-05-25 Stone Lock Global, Inc. Methods and apparatus for biometric verification
US11301670B2 (en) 2012-09-07 2022-04-12 Stone Lock Global, Inc. Methods and apparatus for collision detection in biometric verification
US11275929B2 (en) 2012-09-07 2022-03-15 Stone Lock Global, Inc. Methods and apparatus for privacy protection during biometric verification
US11163984B2 (en) 2012-09-07 2021-11-02 Stone Lock Global, Inc. Methods and apparatus for constructing biometrical templates using facial profiles of users
US11017214B1 (en) 2012-09-07 2021-05-25 Stone Lock Global, Inc. Methods and apparatus for biometric verification
US11017212B2 (en) 2012-09-07 2021-05-25 Stone Lock Global, Inc. Methods and apparatus for biometric verification
US9494577B2 (en) 2012-11-13 2016-11-15 Seahorse Biosciences Apparatus and methods for three-dimensional tissue measurements based on controlled media flow
GB2511772B (en) 2013-03-12 2019-01-30 Ceramex Ltd Testing catalytic efficiency of an exhaust component
RU2530473C1 (en) * 2013-04-23 2014-10-10 федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Вологодский государственный университет" (ВоГУ) Device and method for complex determination of basic thermophysical properties of solid body
US9562849B2 (en) 2013-11-12 2017-02-07 Rebellion Photonics, Inc. Divided-aperture infra-red spectral imaging system
WO2015108969A1 (en) * 2014-01-14 2015-07-23 908 Devices Inc. Sample collection in compact mass spectrometry systems
US9959477B2 (en) * 2014-03-03 2018-05-01 The Board Of Trustees Of The Leland Stanford Junior University Mapping of blood vessels for biometric authentication
US20170026588A1 (en) 2014-05-01 2017-01-26 Rebellion Photonics, Inc. Dual-band divided-aperture infra-red spectral imaging system
US11290662B2 (en) 2014-05-01 2022-03-29 Rebellion Photonics, Inc. Mobile gas and chemical imaging camera
CN106999926A (en) 2014-06-02 2017-08-01 安捷伦科技有限公司 Single-row microplate system and carrier for analyzing biological specimen
US9337007B2 (en) 2014-06-15 2016-05-10 Ionsense, Inc. Apparatus and method for generating chemical signatures using differential desorption
US10458905B2 (en) 2014-07-07 2019-10-29 Rebellion Photonics, Inc. Gas leak emission quantification with a gas cloud imager
CN104502228B (en) * 2014-12-15 2017-03-08 中国航空工业集团公司北京长城航空测控技术研究所 Measuring system and measuring method for oil viscosity detecting line sensor
EP3215812B1 (en) 2014-12-29 2020-10-07 Concentric Meter Corporation Fluid parameter sensor and meter
WO2016109451A1 (en) 2014-12-29 2016-07-07 Concentric Meter Corporation Electromagnetic transducer
US10126266B2 (en) 2014-12-29 2018-11-13 Concentric Meter Corporation Fluid parameter sensor and meter
WO2016142864A1 (en) 2015-03-09 2016-09-15 Alliance For Sustainable Energy, Llc Batch and continuous methods for evaluating the physical and thermal properties of films
US9885147B2 (en) 2015-04-24 2018-02-06 University Of South Carolina Reproducible sample preparation method for quantitative stain detection
US10041866B2 (en) 2015-04-24 2018-08-07 University Of South Carolina Reproducible sample preparation method for quantitative stain detection
CA2987404A1 (en) 2015-05-29 2016-12-08 Rebellion Photonics, Inc. Hydrogen sulfide imaging system
EP3182118B1 (en) * 2015-12-19 2019-03-06 Mems Ag Method and measuring device for determining gas properties using correlation
AT517956B1 (en) * 2015-12-22 2017-06-15 Klaus Stadlmann Dr Method for producing a three-dimensional body
US9899196B1 (en) 2016-01-12 2018-02-20 Jeol Usa, Inc. Dopant-assisted direct analysis in real time mass spectrometry
EP3232204A1 (en) * 2016-04-14 2017-10-18 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Method of tuning parameter settings for performing acoustic scanning probe microscopy for subsurface imaging, scanning probe microscopy system, and computer program product
CN109477802A (en) * 2016-07-19 2019-03-15 艺康美国股份有限公司 Industrial water processing is controlled by digital imagery
WO2018017665A1 (en) 2016-07-19 2018-01-25 Ecolab Usa Inc. Control of industrial water treatment via digital imaging
US10697914B2 (en) * 2016-09-19 2020-06-30 Energy Storage & Retention Solutions Holdings, Llc Rapid high temperature thermal analysis
WO2018075957A1 (en) 2016-10-21 2018-04-26 Rebellion Photonics, Inc. Gas imaging system
CN114609075A (en) 2016-10-21 2022-06-10 瑞柏丽恩光子股份有限公司 Mobile gas and chemical imaging camera
ES2791962T3 (en) * 2016-11-21 2020-11-06 Univ Ruhr Bochum Combined trial for the differential diagnosis of Alzheimer's disease
US10955355B2 (en) 2017-02-22 2021-03-23 Rebellion Photonics, Inc. Systems and methods for monitoring remote installations
JP6853541B2 (en) * 2017-05-31 2021-03-31 株式会社島津製作所 Analysis equipment
CN111201085B (en) 2017-06-30 2022-05-13 思研(Sri)国际顾问与咨询公司 Apparatus for reaction screening and optimization and method thereof
US10636640B2 (en) 2017-07-06 2020-04-28 Ionsense, Inc. Apparatus and method for chemical phase sampling analysis
EP3707497B1 (en) 2017-11-09 2022-09-28 Rebellion Photonics, Inc. Window obscuration sensors for mobile gas and chemical imaging cameras
GB2568946A (en) * 2017-12-01 2019-06-05 Hydramotion Ltd Fluid property measurement by reflection of vibrational waves
CN108195707B (en) * 2017-12-29 2020-04-28 大连理工大学 Method for evaluating influence of ultralow temperature cooling on mechanical properties of material
WO2019231859A1 (en) 2018-06-01 2019-12-05 Ionsense Inc. Apparatus and method for reducing matrix effects when ionizing a sample
WO2020185525A1 (en) * 2019-03-08 2020-09-17 Stone Lock Global, Inc. Methods and apparatus for facial recognition
US11035789B2 (en) 2019-04-03 2021-06-15 Picomole Inc. Cavity ring-down spectroscopy system and method of modulating a light beam therein
EP4052278A4 (en) 2019-10-28 2023-11-22 Ionsense, Inc. Pulsatile flow atmospheric real time ionization
US11768178B2 (en) 2020-02-28 2023-09-26 Baker Hughes Oilfield Operations Llc Embedded electrode tuning fork
US11913861B2 (en) 2020-05-26 2024-02-27 Bruker Scientific Llc Electrostatic loading of powder samples for ionization
USD976904S1 (en) 2020-12-18 2023-01-31 Stone Lock Global, Inc. Biometric scanner
CN113295763B (en) * 2021-06-03 2023-07-25 浙江师范大学 Cross molecular beam detection device capable of eliminating background signal interference of reactants
CN114724646B (en) * 2022-05-05 2023-06-02 北京科技大学 Molecular attribute prediction method based on mass spectrogram and graph structure

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3944826A (en) * 1973-07-19 1976-03-16 Applied Research Laboratories Limited Methods and apparatus for analyzing mixtures
EP0260469A2 (en) * 1986-09-19 1988-03-23 Gesellschaft für Strahlen- und Umweltforschung mbH (GSF) Apparatus for analytically determining organic substances
EP0408487A2 (en) * 1989-07-13 1991-01-16 Aviv Amirav Mass spectrometer method and apparatus for analyzing materials
US5077470A (en) * 1991-01-11 1991-12-31 Jeol Ltd. Mass spectrometer
US5146088A (en) * 1989-12-21 1992-09-08 Vg Instruments Group Limited Method and apparatus for surface analysis
WO1995025737A1 (en) * 1994-03-23 1995-09-28 The Penn State Research Foundation Method for identifying members of combinatorial libraries
WO1996011878A1 (en) * 1994-10-18 1996-04-25 The Regents Of The University Of California The combinatorial synthesis of novel materials
WO1996022530A1 (en) * 1995-01-19 1996-07-25 Chiron Corporation Affinity selection of ligands by mass spectroscopy

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3071961A (en) * 1959-12-22 1963-01-08 Exxon Research Engineering Co Automatic viscometer and process of using same
US3431077A (en) 1966-07-18 1969-03-04 Joseph D Danforth Analytical apparatus
DE1900569C3 (en) * 1969-01-07 1976-01-08 Varian Mat Gmbh, 2800 Bremen Solid-state ion source
US3622968A (en) 1969-05-15 1971-11-23 Amoco Prod Co Elastic-wave holography using reflections
US3636777A (en) * 1969-09-16 1972-01-25 Vision Lab Inc Laboratory beaker transporter and elevator
GB1349257A (en) 1970-04-24 1974-04-03 Rotron Inc Mass flow and mass flow rate indication
US3718032A (en) 1970-09-18 1973-02-27 Hoffmann La Roche Ultrasonic visualization
US3778757A (en) * 1972-09-01 1973-12-11 Gen Electric Method and apparatus for visual imaging ultrasonic echo signals utilizing multiple transmitters for reduced specular reflection effects
US3933044A (en) * 1973-03-15 1976-01-20 Chevron Research Company Method and apparatus for monitoring temperatures during catalytic regeneration
US4023201A (en) * 1976-04-26 1977-05-10 Infrared Surveys, Incorporated Infrared thermography for determining equipment temperatures in oil well fires
US4099923A (en) 1977-01-17 1978-07-11 The Standard Oil Company Automatic catalytic screening unit
US4213326A (en) * 1979-02-14 1980-07-22 The Upjohn Company Sample supply device
US4391338A (en) 1980-04-04 1983-07-05 Harvey Patashnick Microbalance and method for measuring the mass of matter suspended within a fluid medium
WO1981003394A1 (en) * 1980-05-23 1981-11-26 Research Corp Ion vapor source for mass spectrometry of liquids
US4349881A (en) 1980-07-14 1982-09-14 International Telephone And Telegraph Corporation Vibration instruments
US4370662A (en) * 1980-12-02 1983-01-25 Ricoh Company, Ltd. Ink jet array ultrasonic simulation
US4342936A (en) * 1980-12-19 1982-08-03 Eastman Kodak Company High deflection bandwidth product polymeric piezoelectric flexure mode device and method of making same
US4408125A (en) * 1981-07-13 1983-10-04 University Of Utah Modular pyrolysis inlet and method for pyrolyzing compounds for analysis by mass spectrometer
JPS58109859A (en) * 1981-12-24 1983-06-30 Sumitomo Electric Ind Ltd Voltage and electric field measuring device using light
US4819658A (en) * 1982-02-11 1989-04-11 American Telephone And Telegraph Company, At&T Bell Laboratories Method and apparatus for measuring the temperature profile of a surface
US4455741A (en) * 1982-02-11 1984-06-26 At&T Bell Laboratories Fabrication of solid state electronic devices using fluorescent imaging of surface temperature profiles
DE3229050C2 (en) 1982-08-04 1984-11-08 Bopp & Reuther Gmbh, 6800 Mannheim Density meter for gases
DE3301967A1 (en) 1983-01-21 1984-07-26 Siemens AG, 1000 Berlin und 8000 München ULTRASONIC IMAGING SYSTEM
JPS59166840A (en) * 1983-03-11 1984-09-20 Nec Corp Viscosity detector
US4526480A (en) 1983-06-21 1985-07-02 Quartztronics, Inc. Fluid density temperature measurement apparatus and method
US4596697A (en) * 1984-09-04 1986-06-24 The United States Of America As Represented By The Secretary Of The Army Chemical sensor matrix
US4626412A (en) 1984-12-14 1986-12-02 Monsanto Company Method and apparatus for carrying out catalyzed chemical reactions and for studying catalysts
FR2583519B1 (en) 1985-06-17 1988-09-16 Inst Francais Du Petrole ONLINE TEST AND ANALYSIS METHOD AND APPARATUS FOR ESTABLISHING A CHEMICAL REACTION BALANCE SHEET
US4799378A (en) * 1985-10-21 1989-01-24 Alcor, Inc. Piezoelectric viscometer
JPS62137537A (en) 1985-12-12 1987-06-20 Chichibu Cement Co Ltd Sample temperature measuring apparatus for viscosity measuring device
US4779451A (en) 1986-02-17 1988-10-25 Hitachi, Ltd. System for measuring foreign materials in liquid
CH669671A5 (en) * 1986-02-24 1989-03-31 Hatschek Rudolf A
US4791292A (en) * 1986-04-24 1988-12-13 The Dow Chemical Company Capillary membrane interface for a mass spectrometer
GB8612221D0 (en) 1986-05-20 1986-06-25 Amersham Int Plc Assaying species in sample
US4910523A (en) * 1987-11-06 1990-03-20 Millitech Corporation Micrometer wave imaging device
US4741200A (en) 1986-07-11 1988-05-03 Ford Motor Company Method and apparatus for measuring viscosity in a liquid utilizing a piezoelectric sensor
US4734609A (en) 1986-07-25 1988-03-29 Calogic Corporation Gas density transducer
US4760351A (en) 1986-08-22 1988-07-26 Northern Illinois University Multiple oscillator device having plural quartz resonators in a common quartz substrate
GB8621119D0 (en) 1986-09-01 1986-10-08 Thompson B A Mushroom cultivation
GB2194847A (en) * 1986-09-05 1988-03-16 Marconi Co Ltd Image converter
US4705616A (en) * 1986-09-15 1987-11-10 Sepragen Corporation Electrophoresis-mass spectrometry probe
EP0262637B1 (en) * 1986-09-29 1995-03-22 Mitsubishi Chemical Corporation Piezoelectric actuator
US4721874A (en) 1986-10-06 1988-01-26 Emmert Sans W Apparatus and method for determining the viscosity of a fluid sample
GB8705757D0 (en) * 1987-03-11 1987-04-15 Schlumberger Electronics Uk Fluid transducer
US4928254A (en) * 1988-04-28 1990-05-22 Knudsen Arne K Laser flash thermal conductivity apparatus and method
US5283037A (en) 1988-09-29 1994-02-01 Hewlett-Packard Company Chemical sensor utilizing a surface transverse wave device
US5306644A (en) 1988-09-29 1994-04-26 Hewlett-Packard Company Mass sensor method for measuring analytes in a sample
US5037611A (en) * 1988-11-29 1991-08-06 Icr Research Associates, Inc. Sample handling technique
US5206806A (en) 1989-01-10 1993-04-27 Gerardi Joseph J Smart skin ice detection and de-icing system
US4922200A (en) * 1989-08-25 1990-05-01 Ldj Electronics, Inc. Apparatus for measuring the hysteresis loop of magnetic film
US5296374A (en) 1989-10-20 1994-03-22 University Of Strathclyde Apparatus for assessing a particular property in a medium
US5124635A (en) * 1990-02-15 1992-06-23 Photon Dynamics, Inc. Voltage imaging system using electro-optics
US5179028A (en) 1990-04-20 1993-01-12 Hughes Aircraft Company Antibody coated crystal chemical sensor
US5224174A (en) * 1990-11-07 1993-06-29 Niagara Technology Incorporated Surface feature mapping using high resolution c-scan ultrasonography
US5375470A (en) * 1990-12-20 1994-12-27 Fujitsu Limited Acoustic imaging system
US5210412A (en) * 1991-01-31 1993-05-11 Wayne State University Method for analyzing an organic sample
JPH04307312A (en) * 1991-04-03 1992-10-29 Otsuka Denshi Kk Measuring method of thickness of gap of liquid crystal cell
US5244814A (en) * 1991-05-20 1993-09-14 Forintek Canada Corporation Decay detection in wood
DE69212157T2 (en) * 1991-05-31 1996-11-21 Alcan Int Ltd METHOD AND DEVICE FOR PRODUCING PROFILED PANELS FROM PARTICLE-STABILIZED METAL FOAM
JPH0518858A (en) * 1991-07-12 1993-01-26 Casio Comput Co Ltd Method for measuring optical characteristic of membrane
EP0523425B1 (en) * 1991-07-16 1996-01-24 Johnson & Johnson Clinical Diagnostics, Inc. Device for taking up and covering containers arranged in a line and filled with liquid to be analyzed
US5253530A (en) 1991-08-12 1993-10-19 Letcher Iii John H Method and apparatus for reflective ultrasonic imaging
US5200023A (en) 1991-08-30 1993-04-06 International Business Machines Corp. Infrared thermographic method and apparatus for etch process monitoring and control
US5294198A (en) * 1991-10-01 1994-03-15 Cincinnati Electronics Corporation Infrared inspection system and method employing emissivity indications
US5201215A (en) * 1991-10-17 1993-04-13 The United States Of America As Represented By The United States Department Of Energy Method for simultaneous measurement of mass loading and fluid property changes using a quartz crystal microbalance
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
JPH05168610A (en) 1991-12-20 1993-07-02 Kawatetsu Techno Res Corp Fingerprint detecting method
US5344236A (en) * 1992-01-23 1994-09-06 Fishman Iiya M Method for evaluation of quality of the interface between layer and substrate
US5276319A (en) * 1992-04-21 1994-01-04 The United States Of America As Represented By The United States Secretary Of The Navy Method and device for improved IR detection with compensations for individual detector response
US5469369A (en) 1992-11-02 1995-11-21 The United States Of America As Represented By The Secretary Of The Navy Smart sensor system and method using a surface acoustic wave vapor sensor array and pattern recognition for selective trace organic vapor detection
US5524636A (en) * 1992-12-21 1996-06-11 Artann Corporation Dba Artann Laboratories Method and apparatus for elasticity imaging
US5357964A (en) * 1993-02-08 1994-10-25 Spivey Brett A Doppler imaging device
US5394752A (en) * 1993-03-16 1995-03-07 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method for determing shear direction using liquid crystal coatings
JP3298974B2 (en) * 1993-03-23 2002-07-08 電子科学株式会社 Thermal desorption gas analyzer
US5450205A (en) * 1993-05-28 1995-09-12 Massachusetts Institute Of Technology Apparatus and method for real-time measurement of thin film layer thickness and changes thereof
US5534698A (en) 1993-07-07 1996-07-09 Research Development Corporation Solid state surface evaluation methods and devices
US5741961A (en) * 1993-08-18 1998-04-21 Sandia Corporation Quartz resonator fluid density and viscosity monitor
US5455475A (en) * 1993-11-01 1995-10-03 Marquette University Piezoelectric resonant sensor using the acoustoelectric effect
US5446334A (en) * 1994-01-24 1995-08-29 Gre, Incorporated Piezoluminescent, pyroluminescent sensor
JPH07226884A (en) * 1994-02-14 1995-08-22 Mitsubishi Electric Corp Solid-state image pickup device
US5488866A (en) * 1994-04-11 1996-02-06 Tektronix, Inc. Time-interleaved method for efficient operation of an acoustic wave sensor array
US5454045A (en) 1994-04-15 1995-09-26 Battelle Memorial Institute Apparatus and method for identification and recognition of an item with ultrasonic patterns from item subsurface micro-features
EP0678323A1 (en) * 1994-04-18 1995-10-25 Shell Internationale Researchmaatschappij B.V. Removing ammonia from an ammonia-containing gas mixture
US5653539A (en) * 1994-05-02 1997-08-05 Rosengaus; Eliezer Method and apparatus for remotely measuring the temperature of a surface
US5705399A (en) 1994-05-20 1998-01-06 The Cooper Union For Advancement Of Science And Art Sensor and method for detecting predetermined chemical species in solution
GB9410426D0 (en) * 1994-05-25 1994-07-13 Stevenson Adrian C Acoustic monitor assembly
US5770038A (en) 1994-06-29 1998-06-23 Sanyo Electric Co., Ltd. Method for detecting chemical substances
US6060677A (en) 1994-08-19 2000-05-09 Tiedemanns-Jon H. Andresen Ans Determination of characteristics of material
US5545897A (en) * 1994-10-04 1996-08-13 Santa Barbara Research Center Optically-based chemical detection system
US6013199A (en) 1997-03-04 2000-01-11 Symyx Technologies Phosphor materials
US6030917A (en) 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
US6004617A (en) 1994-10-18 1999-12-21 The Regents Of The University Of California Combinatorial synthesis of novel materials
US6045671A (en) 1994-10-18 2000-04-04 Symyx Technologies, Inc. Systems and methods for the combinatorial synthesis of novel materials
JP3388060B2 (en) * 1994-11-25 2003-03-17 日本碍子株式会社 Fluid characteristic measuring element and fluid characteristic measuring device
US5571401A (en) 1995-03-27 1996-11-05 California Institute Of Technology Sensor arrays for detecting analytes in fluids
US5744902A (en) * 1995-05-16 1998-04-28 The United States Of America As Represented By The Secretary Of The Army Chemical and biological sensor based on microresonators
US5850284A (en) * 1995-06-13 1998-12-15 Robotic Vision Systems, Inc. Apparatus for detecting a polarization altering substance on a surface
US6063633A (en) * 1996-02-28 2000-05-16 The University Of Houston Catalyst testing process and apparatus
US5734098A (en) * 1996-03-25 1998-03-31 Nalco/Exxon Energy Chemicals, L.P. Method to monitor and control chemical treatment of petroleum, petrochemical and processes with on-line quartz crystal microbalance sensors
WO1997043308A1 (en) * 1996-05-10 1997-11-20 Endorex Corporation Lipophile derivatives of muramylpeptides for treatment of retroviral infection and induction of chemokines
US5852229A (en) * 1996-05-29 1998-12-22 Kimberly-Clark Worldwide, Inc. Piezoelectric resonator chemical sensing device
US5866430A (en) * 1996-06-13 1999-02-02 Grow; Ann E. Raman optrode processes and devices for detection of chemicals and microorganisms
DE19628178C1 (en) * 1996-07-12 1997-09-18 Bruker Franzen Analytik Gmbh Loading matrix-assisted laser desorption-ionisation sample plate for mass spectrometric analysis
DE19632779A1 (en) 1996-08-15 1998-02-19 Hoechst Ag Method and device for investigating chemical reactions in miniaturized reactors connected in parallel
US6044694A (en) * 1996-08-28 2000-04-04 Videojet Systems International, Inc. Resonator sensors employing piezoelectric benders for fluid property sensing
EP0934515B1 (en) * 1996-10-09 2006-03-08 Symyx Technologies, Inc. Infrared spectroscopy and imaging of libraries
DE19642261A1 (en) 1996-10-11 1998-04-16 Hoechst Ag Method and device for detecting the catalytic activity of solids
US6151123A (en) 1997-07-14 2000-11-21 Symyx Technologies, Inc. Systems and methods for employing optical probes to characterize material properties
US6242262B1 (en) * 1997-10-24 2001-06-05 The University Of North Carolina At Chapel Hill Method and apparatus for screening catalyst libraries
EP1040348B1 (en) * 1997-12-23 2005-11-16 HTE Aktiengesellschaft The High Throughput Experimentation Company Method for combinatorial material development using differential thermal images
US6034240A (en) 1998-03-09 2000-03-07 Symyx Technologies, Inc. Substituted aminomethylphosphines, coordination complexes of aminomethylphosphines and their synthesis
US6087181A (en) 1998-03-16 2000-07-11 Symyx Technologies Sampling and detection of trace gas species by optical spectroscopy
US20030048341A1 (en) * 2000-09-25 2003-03-13 Mutz Mitchell W. High-throughput biomolecular crystallization and biomolecular crystal screening
US20040253141A1 (en) * 2003-06-16 2004-12-16 Schembri Carol T. Apparatus and method for nucleic acid spatial ordering

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3944826A (en) * 1973-07-19 1976-03-16 Applied Research Laboratories Limited Methods and apparatus for analyzing mixtures
EP0260469A2 (en) * 1986-09-19 1988-03-23 Gesellschaft für Strahlen- und Umweltforschung mbH (GSF) Apparatus for analytically determining organic substances
EP0408487A2 (en) * 1989-07-13 1991-01-16 Aviv Amirav Mass spectrometer method and apparatus for analyzing materials
US5146088A (en) * 1989-12-21 1992-09-08 Vg Instruments Group Limited Method and apparatus for surface analysis
US5077470A (en) * 1991-01-11 1991-12-31 Jeol Ltd. Mass spectrometer
WO1995025737A1 (en) * 1994-03-23 1995-09-28 The Penn State Research Foundation Method for identifying members of combinatorial libraries
WO1996011878A1 (en) * 1994-10-18 1996-04-25 The Regents Of The University Of California The combinatorial synthesis of novel materials
WO1996022530A1 (en) * 1995-01-19 1996-07-25 Chiron Corporation Affinity selection of ligands by mass spectroscopy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HUANG Y ET AL: "COLLISION-INDUCED DISSOCIATION FOR MASS SPECTROMETRIC ANALYSIS OF BIOPOLYMERS: HIGH-RESOLUTION FOURIER TRANSFORM ION CYCLOTRON RESONANCE MS4", ANALYTICAL CHEMISTRY, vol. 66, no. 24, 15 December 1994 (1994-12-15), pages 4385 - 4389, XP000485675 *
KELLY M A ET AL: "Characterization of SH2-Ligand Interactions via Library Affinity Selection with Mass Spectrometric Detection", BIOCHEMISTRY, vol. 35, no. 36, 10 September 1996 (1996-09-10), pages 11747 - 11755, XP002062459 *

Also Published As

Publication number Publication date
US6849460B2 (en) 2005-02-01
WO1998015969A2 (en) 1998-04-16
US5959297A (en) 1999-09-28
US7551285B2 (en) 2009-06-23
ATE222401T1 (en) 2002-08-15
US20050164304A1 (en) 2005-07-28
US6401519B1 (en) 2002-06-11
DE69730883D1 (en) 2004-10-28
EP1280185A1 (en) 2003-01-29
ATE319988T1 (en) 2006-03-15
EP1021711A2 (en) 2000-07-26
EP0934515A1 (en) 1999-08-11
EP1019947A2 (en) 2000-07-19
CA2267897A1 (en) 1998-04-16
US7364697B2 (en) 2008-04-29
DE69735411T2 (en) 2006-09-07
US6182499B1 (en) 2001-02-06
US20020197731A1 (en) 2002-12-26
DE69714789D1 (en) 2002-09-19
DE69714789T2 (en) 2002-12-05
US6034775A (en) 2000-03-07
WO1998015813A1 (en) 1998-04-16
EP1019947B1 (en) 2002-08-14
US20090002708A1 (en) 2009-01-01
EP1669738A2 (en) 2006-06-14
WO1998015501A3 (en) 1998-06-25
WO1998015805A1 (en) 1998-04-16
DE69735411D1 (en) 2006-05-04
DE69714789T4 (en) 2004-04-22
EP1021711A4 (en) 2000-07-26
AU4812097A (en) 1998-05-05
AU4749397A (en) 1998-05-05
EP1280185B1 (en) 2004-09-22
AU4673497A (en) 1998-05-05
CA2267908C (en) 2002-07-09
ATE277422T1 (en) 2004-10-15
EP0934515B1 (en) 2006-03-08
CA2267908A1 (en) 1998-04-16
WO1998015501A2 (en) 1998-04-16
US6541271B1 (en) 2003-04-01
CA2267897C (en) 2005-12-06
DK1019947T3 (en) 2002-12-02
US20090045341A1 (en) 2009-02-19
DE69730883T2 (en) 2005-01-27
US6373570B1 (en) 2002-04-16
ES2182040T3 (en) 2003-03-01
EP1669738A3 (en) 2007-12-12
AU4902497A (en) 1998-05-05

Similar Documents

Publication Publication Date Title
WO1998015969A3 (en) Mass spectrometers and methods for rapid screening of libraries of different materials
US7217920B2 (en) Pancake spectrometer
US5834771A (en) Ion mobility spectrometer utilizing flexible printed circuit board and method for manufacturing thereof
US6646253B1 (en) Gas inlet for an ion source
JP4063673B2 (en) Method and apparatus for chromatographic high field asymmetric waveform ion mobility spectrometry
WO1998053300A3 (en) System and apparaus for sequential processing of analytes
CA1151559A (en) Method and apparatus for sonic separation and analysis of components of a fluid mixture
WO2002066952A3 (en) Mass defect labeling for the determination of oligomer sequences
EP1249705A3 (en) Multiplexed molecular analysis apparatus and its fabrication method
WO1993019481A1 (en) Ion source and sample introduction method and apparatus
EP0855596B1 (en) Gas chromatograph system
CA2343744A1 (en) Parallel fluid electrospray mass spectrometer
WO1999032663A3 (en) High throughput assay system
Wang et al. A multiple electrospray interface for parallel mass spectrometric analyses of compound libraries
US20080067350A1 (en) Multi-channel high-field asymmetric waveform ion mobility spectrometry
Triolo et al. Mass spectrometry and combinatorial chemistry: a short outline
TWI254647B (en) Method of separating compound(s) from mixture(s)
Novak et al. Thin layer chromatography-laser mass spectrometry (TLC-LMS) of triphenylmethane dyes: Initial results
CA2237255A1 (en) Method for improving signal-to-noise for multiply charged ions
Tørnes Identification of some alkyl methylphosphonic acids by thermospray tandem mass spectrometry
Varray et al. Poly (ethyleneglycol) in electrospray ionization (ESI) mass spectrometry
EP0772224B1 (en) Analysis of samples
US7544233B2 (en) Gas chromatograph with a mass spectrometer situated down therefrom, and method for performing the gas chromatographic/mass spectrometric analysis of a substance mixture
EP3817029A1 (en) Method and apparatus for mass analysing a first sample
WO2003044825A1 (en) High resolution automated maldi data analysis

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2267908

Country of ref document: CA

Ref country code: CA

Ref document number: 2267908

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1997910017

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1997910017

Country of ref document: EP

AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

WWG Wipo information: grant in national office

Ref document number: 1997910017

Country of ref document: EP