WO1998013493A3 - A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof - Google Patents

A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof Download PDF

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Publication number
WO1998013493A3
WO1998013493A3 PCT/US1997/017154 US9717154W WO9813493A3 WO 1998013493 A3 WO1998013493 A3 WO 1998013493A3 US 9717154 W US9717154 W US 9717154W WO 9813493 A3 WO9813493 A3 WO 9813493A3
Authority
WO
WIPO (PCT)
Prior art keywords
sarp
peptides
methods
family
genes encoding
Prior art date
Application number
PCT/US1997/017154
Other languages
French (fr)
Other versions
WO1998013493A2 (en
WO1998013493A9 (en
Inventor
Samuil Umansky
Hovsep Melkonyan
Original Assignee
Lxr Biotechnology Inc
Samuil Umansky
Hovsep Melkonyan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26701439&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1998013493(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lxr Biotechnology Inc, Samuil Umansky, Hovsep Melkonyan filed Critical Lxr Biotechnology Inc
Priority to JP51587798A priority Critical patent/JP4299886B2/en
Priority to CA2266325A priority patent/CA2266325C/en
Priority to EP97945277A priority patent/EP0932678B2/en
Priority to DE69735375T priority patent/DE69735375T3/en
Priority to AU46513/97A priority patent/AU737323B2/en
Priority to DK97945277.8T priority patent/DK0932678T4/en
Publication of WO1998013493A2 publication Critical patent/WO1998013493A2/en
Publication of WO1998013493A3 publication Critical patent/WO1998013493A3/en
Publication of WO1998013493A9 publication Critical patent/WO1998013493A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

An isolated polynucleotide at leat 60 % homologous to SEQ ID NO: 1, 3, 5 or 18 encoding a SARP polypeptide; vectors comprising a polynucleotide sequence encoding at least 11 consecutive amino acids of αSARP polypeptide; a host cell transformed with an isolated polynucleotide or vector; antibodies specific for SARP and use of such polynucleotides and antibodies in diagnostic and therapeutic method. Therapeutic uses of antibodies and polynucleotides of sarp. Methods for treating diseases related to the regulation of SARP expression in tissue and bodily fluid samples, including cancers.
PCT/US1997/017154 1996-09-24 1997-09-24 A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof WO1998013493A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP51587798A JP4299886B2 (en) 1996-09-24 1997-09-24 Gene family encoding apoptosis-related peptides, peptides encoded thereby, and methods of use thereof
CA2266325A CA2266325C (en) 1996-09-24 1997-09-24 A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof
EP97945277A EP0932678B2 (en) 1996-09-24 1997-09-24 A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof
DE69735375T DE69735375T3 (en) 1996-09-24 1997-09-24 GENE FAMILY OF APOPTOSIS-RELATED PEPTIDES, THEREFORE, ENCODED PEPTIDES AND METHOD FOR THE PRODUCTION THEREOF
AU46513/97A AU737323B2 (en) 1996-09-24 1997-09-24 A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof
DK97945277.8T DK0932678T4 (en) 1996-09-24 1997-09-24 A family of genes encoding apoptosis-related peptides, peptides encoded therein, and methods for their use

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2660396P 1996-09-24 1996-09-24
US60/026,603 1996-09-24
US2836396P 1996-10-11 1996-10-11
US60/028,363 1996-10-11

Publications (3)

Publication Number Publication Date
WO1998013493A2 WO1998013493A2 (en) 1998-04-02
WO1998013493A3 true WO1998013493A3 (en) 1998-06-04
WO1998013493A9 WO1998013493A9 (en) 1998-07-09

Family

ID=26701439

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/017154 WO1998013493A2 (en) 1996-09-24 1997-09-24 A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof

Country Status (11)

Country Link
US (3) US6433155B1 (en)
EP (1) EP0932678B2 (en)
JP (2) JP4299886B2 (en)
AT (1) ATE318915T1 (en)
AU (1) AU737323B2 (en)
CA (1) CA2266325C (en)
DE (1) DE69735375T3 (en)
DK (1) DK0932678T4 (en)
ES (1) ES2263181T5 (en)
PT (1) PT932678E (en)
WO (1) WO1998013493A2 (en)

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DE69726884T2 (en) 1997-02-06 2004-06-03 Genetics Institute, LLC, Cambridge HUMAN SDF-5 PROTEIN AND RELATED COMPOSITIONS
CA2224473A1 (en) * 1997-05-21 1998-11-21 Smithkline Beecham Corporation A novel human gene similar to a secreted murine protein sdf5
EP0879885A1 (en) * 1997-05-23 1998-11-25 Smithkline Beecham Corporation A novel human gene similar to a secreted murine protein sFRP-1
US6479255B1 (en) * 1997-05-29 2002-11-12 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Polynucleotides encoding human FRP and fragments thereof
US20030203446A1 (en) * 1998-10-07 2003-10-30 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2000026391A2 (en) * 1998-10-30 2000-05-11 University Of Nebraska-Lincoln Trans-species transfer of apoptotic genes and transgenic plants developed thereby
GB9921009D0 (en) * 1999-09-07 1999-11-10 Neuropa Ltd Essential genes and assays relating thereto
US20080166356A9 (en) * 1999-09-13 2008-07-10 Peter Bodine Pharmaceutical compositions and methods of using secreted frizzled related protein
US6600018B1 (en) 2000-04-10 2003-07-29 The United States Of America As Represented By The Department Of Health And Human Services Secreted frizzled related protein, sFRP, fragments and methods of use thereof
JP2004525869A (en) * 2000-12-06 2004-08-26 アプライド・リサーチ・システムズ・エイアールエス・ホールディング・ナムローゼ・フェンノートシャップ Use of SARP-1 for the treatment and / or prevention of scleroderma
JP4029041B2 (en) 2001-01-10 2008-01-09 アメリカ合衆国 sFRP and peptide motifs interacting with sFRP and methods of use thereof
EP1222933A1 (en) * 2001-01-15 2002-07-17 Academisch Ziekenhuis Leiden h.o.d.n., Leids Universitair Medisch Centrum Generation and/or reduction of new lung tissue in an affected lung, by modulation of the Wnt-pathway
US7682607B2 (en) 2001-05-01 2010-03-23 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
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CN101156943A (en) * 2003-12-16 2008-04-09 安万特药物公司 Secreted neural apoptosis inhibiting proteins
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WO2008031009A2 (en) * 2006-09-08 2008-03-13 Genentech, Inc. Wnt antagonists and their use in the diagnosis and treatment of wnt-mediated disorders
PT2331136T (en) * 2008-09-26 2018-03-27 Oncomed Pharm Inc Frizzled-binding agents and uses thereof
TWI535445B (en) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Wnt antagonists and methods of treatment and screening
KR20130043102A (en) 2010-04-01 2013-04-29 온코메드 파마슈티칼스, 인크. Frizzled-binding agents and uses thereof
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US20120237975A1 (en) 2010-10-01 2012-09-20 Jason Schrum Engineered nucleic acids and methods of use thereof
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3682905B1 (en) 2011-10-03 2021-12-01 ModernaTX, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
RS63244B1 (en) 2011-12-16 2022-06-30 Modernatx Inc Modified mrna compositions
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
EP2833892A4 (en) 2012-04-02 2016-07-20 Moderna Therapeutics Inc Modified polynucleotides for the production of oncology-related proteins and peptides
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
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Also Published As

Publication number Publication date
DE69735375T3 (en) 2010-09-02
PT932678E (en) 2006-07-31
ATE318915T1 (en) 2006-03-15
CA2266325C (en) 2012-07-17
EP0932678B1 (en) 2006-03-01
US20030023061A1 (en) 2003-01-30
WO1998013493A2 (en) 1998-04-02
AU4651397A (en) 1998-04-17
DK0932678T4 (en) 2010-07-12
US6433155B1 (en) 2002-08-13
ES2263181T5 (en) 2011-04-07
US7045604B2 (en) 2006-05-16
EP0932678B2 (en) 2010-03-10
EP0932678A2 (en) 1999-08-04
US7045596B2 (en) 2006-05-16
JP4299886B2 (en) 2009-07-22
ES2263181T3 (en) 2006-12-01
DE69735375T2 (en) 2006-11-30
JP2002516564A (en) 2002-06-04
DE69735375D1 (en) 2006-04-27
DK0932678T3 (en) 2006-05-22
AU737323B2 (en) 2001-08-16
JP2009050257A (en) 2009-03-12
US20040039184A1 (en) 2004-02-26
CA2266325A1 (en) 1998-04-02

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