WO1998009170A3 - Methods and compositions for the detection of cervical cancer - Google Patents

Methods and compositions for the detection of cervical cancer Download PDF

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Publication number
WO1998009170A3
WO1998009170A3 PCT/US1997/014526 US9714526W WO9809170A3 WO 1998009170 A3 WO1998009170 A3 WO 1998009170A3 US 9714526 W US9714526 W US 9714526W WO 9809170 A3 WO9809170 A3 WO 9809170A3
Authority
WO
WIPO (PCT)
Prior art keywords
cervical cancer
detection
provides
methods
compositions
Prior art date
Application number
PCT/US1997/014526
Other languages
French (fr)
Other versions
WO1998009170A2 (en
Inventor
Susan K Keesee
Robert Obar
Ying-Jye Wu
Original Assignee
Matritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matritech Inc filed Critical Matritech Inc
Priority to JP51170698A priority Critical patent/JP4116082B2/en
Priority to DE69736293T priority patent/DE69736293T2/en
Priority to EP97938400A priority patent/EP0923740B1/en
Priority to AU40732/97A priority patent/AU4073297A/en
Priority to CA002263888A priority patent/CA2263888C/en
Publication of WO1998009170A2 publication Critical patent/WO1998009170A2/en
Publication of WO1998009170A3 publication Critical patent/WO1998009170A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57411—Specifically defined cancers of cervix
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with a labeled binding moiety, for example, a labeled antibody capable of binding specifically to the protein. The invention also provides kits useful in the detection of cervical cancer in an individual. In addition, the invention provides methods utilizing the cervical cancer-associated proteins either as targets for treating cervical cancer or as indicators for monitoring of the efficacy of such a treatment.
PCT/US1997/014526 1996-08-30 1997-08-19 Methods and compositions for the detection of cervical cancer WO1998009170A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP51170698A JP4116082B2 (en) 1996-08-30 1997-08-19 Methods and compositions for detection of cervical cancer
DE69736293T DE69736293T2 (en) 1996-08-30 1997-08-19 METHOD AND COMPOSITION FOR THE PREPARATION OF CERVIX CANCER
EP97938400A EP0923740B1 (en) 1996-08-30 1997-08-19 Methods and compositions for the detection of cervical cancer
AU40732/97A AU4073297A (en) 1996-08-30 1997-08-19 Methods and compositions for the detection of cervical cancer
CA002263888A CA2263888C (en) 1996-08-30 1997-08-19 Methods and compositions for the detection of cervical cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/705,660 1996-08-30
US08/705,660 US5858683A (en) 1996-08-30 1996-08-30 Methods and compositions for the detection of cervical cancer

Publications (2)

Publication Number Publication Date
WO1998009170A2 WO1998009170A2 (en) 1998-03-05
WO1998009170A3 true WO1998009170A3 (en) 1998-04-23

Family

ID=24834422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/014526 WO1998009170A2 (en) 1996-08-30 1997-08-19 Methods and compositions for the detection of cervical cancer

Country Status (9)

Country Link
US (4) US5858683A (en)
EP (1) EP0923740B1 (en)
JP (1) JP4116082B2 (en)
AT (1) ATE332505T1 (en)
AU (1) AU4073297A (en)
CA (1) CA2263888C (en)
DE (1) DE69736293T2 (en)
ES (1) ES2268735T3 (en)
WO (1) WO1998009170A2 (en)

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Also Published As

Publication number Publication date
US6027905A (en) 2000-02-22
WO1998009170A2 (en) 1998-03-05
US20030157482A1 (en) 2003-08-21
EP0923740A2 (en) 1999-06-23
ATE332505T1 (en) 2006-07-15
JP2001500609A (en) 2001-01-16
DE69736293T2 (en) 2007-06-14
AU4073297A (en) 1998-03-19
DE69736293D1 (en) 2006-08-17
JP4116082B2 (en) 2008-07-09
US5858683A (en) 1999-01-12
ES2268735T3 (en) 2007-03-16
US20050164313A1 (en) 2005-07-28
CA2263888C (en) 2004-10-26
US6803189B2 (en) 2004-10-12
CA2263888A1 (en) 1998-03-05
EP0923740B1 (en) 2006-07-05

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