WO1998004249A2 - Tramadol multiple unit formulierungen - Google Patents
Tramadol multiple unit formulierungen Download PDFInfo
- Publication number
- WO1998004249A2 WO1998004249A2 PCT/EP1997/003934 EP9703934W WO9804249A2 WO 1998004249 A2 WO1998004249 A2 WO 1998004249A2 EP 9703934 W EP9703934 W EP 9703934W WO 9804249 A2 WO9804249 A2 WO 9804249A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- release
- formulations according
- pharmaceutical formulations
- pellets
- eudragit
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
Description
Claims
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SK98-99A SK285300B6 (sk) | 1996-07-25 | 1997-07-19 | Farmaceutická formulácia obsahujúca množinu liekových podjednotiek a spôsob jej výroby |
NZ333822A NZ333822A (en) | 1996-07-25 | 1997-07-19 | Tramadol multiple unit formulations comprising individual pellets of trmadol coated with one or more membrane layers for controlling release |
EP97935532A EP0917463B1 (de) | 1996-07-25 | 1997-07-19 | Tramadol multiple unit formulierungen |
IL12791597A IL127915A (en) | 1996-07-25 | 1997-07-19 | Preparations with many units of tramadol consisting of sustained release pills |
PL97331387A PL188834B1 (pl) | 1996-07-25 | 1997-07-19 | Farmaceutyczne formulacje zawierające tramadol lub jego fizjologicznie akceptowane sole oraz sposóbwytwarzania tych formulacji |
AT97935532T ATE213408T1 (de) | 1996-07-25 | 1997-07-19 | Tramadol multiple unit formulierungen |
HU9903053A HU227971B1 (en) | 1996-07-25 | 1997-07-19 | Tramadol multiple unit formulations and process for producing them |
BR9710761A BR9710761A (pt) | 1996-07-25 | 1997-07-19 | Formula-{es de unidade mÚltipla de tramadol |
DE59706441T DE59706441D1 (de) | 1996-07-25 | 1997-07-19 | Tramadol multiple unit formulierungen |
EEP199900031A EE03742B1 (et) | 1996-07-25 | 1997-07-19 | Tramadooli mitmikühikulised preparaadid ja nende valmistamismeetod |
DK97935532T DK0917463T3 (da) | 1996-07-25 | 1997-07-19 | Tramadol-flerenhedsformuleringer |
AU38491/97A AU737121B2 (en) | 1996-07-25 | 1997-07-19 | Tramadol multiple unit formulations |
UA99021086A UA52679C2 (uk) | 1996-07-25 | 1997-07-19 | Фармацевтична композиція, що містить велику кількість одиниць трамадолу, і спосіб її приготування |
JP50846698A JP3631762B2 (ja) | 1996-07-25 | 1997-07-19 | トラマドール複式ユニット製剤 |
NO19990261A NO324207B1 (no) | 1996-07-25 | 1999-01-21 | Farmasoytiske multiple enhetsformuleringer med tramadol, samt fremgangsmate til fremstilling derav. |
BG103158A BG63708B1 (bg) | 1996-07-25 | 1999-02-09 | Лекарствени форми на трамадол |
HK99106029A HK1020876A1 (en) | 1996-07-25 | 1999-12-22 | Tramadol multiple unit formulations |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19630035A DE19630035A1 (de) | 1996-07-25 | 1996-07-25 | Tramadol Multiple Unit Formulierungen |
DE19630035.5 | 1996-07-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998004249A2 true WO1998004249A2 (de) | 1998-02-05 |
WO1998004249A3 WO1998004249A3 (de) | 1998-04-30 |
Family
ID=7800815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1997/003934 WO1998004249A2 (de) | 1996-07-25 | 1997-07-19 | Tramadol multiple unit formulierungen |
Country Status (29)
Country | Link |
---|---|
US (2) | US5955104A (de) |
EP (1) | EP0917463B1 (de) |
JP (1) | JP3631762B2 (de) |
KR (1) | KR100474793B1 (de) |
CN (1) | CN1111402C (de) |
AR (1) | AR008002A1 (de) |
AT (1) | ATE213408T1 (de) |
AU (1) | AU737121B2 (de) |
BG (1) | BG63708B1 (de) |
BR (1) | BR9710761A (de) |
CA (1) | CA2211284C (de) |
CZ (1) | CZ296964B6 (de) |
DE (2) | DE19630035A1 (de) |
DK (1) | DK0917463T3 (de) |
EE (1) | EE03742B1 (de) |
ES (1) | ES2171268T3 (de) |
HK (1) | HK1020876A1 (de) |
HU (1) | HU227971B1 (de) |
IL (1) | IL127915A (de) |
NO (1) | NO324207B1 (de) |
NZ (1) | NZ333822A (de) |
PL (1) | PL188834B1 (de) |
PT (1) | PT917463E (de) |
RU (1) | RU2201223C2 (de) |
SK (1) | SK285300B6 (de) |
TW (1) | TW495363B (de) |
UA (1) | UA52679C2 (de) |
WO (1) | WO1998004249A2 (de) |
ZA (1) | ZA975408B (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1094790A1 (de) * | 1998-07-07 | 2001-05-02 | Cascade Development, Inc. | Pharmazeutische zubereitung mit verzögerter wirkstofffreisetzung |
EP1424068A1 (de) * | 2002-11-27 | 2004-06-02 | Oramon Arzneimittel GmbH | Verfahren zur Herstellung von Pellets, enthaltend ein tri- oder tetracyclisches Antidepressivum sowie diese Pellets enthaltende pharmazeutische Zubereitungen |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19630035A1 (de) * | 1996-07-25 | 1998-01-29 | Asta Medica Ag | Tramadol Multiple Unit Formulierungen |
US6197347B1 (en) * | 1998-06-29 | 2001-03-06 | Andrx Pharmaceuticals, Inc. | Oral dosage for the controlled release of analgesic |
DE19901686A1 (de) | 1999-01-18 | 2000-07-20 | Gruenenthal Gmbh | Retardierte Tramadolzubereitungen mit einem lagerstabilen Freisetzungsprofil und Verfahren zu deren Herstellung |
DE19901687B4 (de) * | 1999-01-18 | 2006-06-01 | Grünenthal GmbH | Opioide Analgetika mit kontrollierter Wirkstofffreisetzung |
DE19940944B4 (de) * | 1999-08-31 | 2006-10-12 | Grünenthal GmbH | Retardierte, orale, pharmazeutische Darreichungsformen |
BR0013825A (pt) | 1999-08-31 | 2002-07-23 | Gruenenthal Chemie | Formas de apresentação de tramadol |
KR101216270B1 (ko) | 1999-10-29 | 2012-12-31 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
AR030557A1 (es) * | 2000-04-14 | 2003-08-27 | Jagotec Ag | Una tableta en multicapa de liberacion controlada y metodo de tratamiento |
US6620431B1 (en) | 2000-04-17 | 2003-09-16 | Charles Signorino | Shellac film coatings providing release at selected pH and method |
US20030157247A1 (en) * | 2000-06-14 | 2003-08-21 | Yoshiro Chikami | Method for producing coated bioactive granule |
HUP0301416A2 (hu) * | 2000-07-06 | 2003-09-29 | Delsys Pharmaceutical Corporation | Javított tiroid hormon gyógyszerformák |
AU2002227383B2 (en) | 2000-10-30 | 2004-07-08 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
DE10108122A1 (de) | 2001-02-21 | 2002-10-02 | Gruenenthal Gmbh | Arzneimittel auf Basis von Tramadol |
US20030104976A1 (en) * | 2001-07-23 | 2003-06-05 | Gudarz Davar | Analgesic methods using endothelin receptor ligands |
PE20030527A1 (es) | 2001-10-24 | 2003-07-26 | Gruenenthal Chemie | Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen |
US20050182056A9 (en) * | 2002-02-21 | 2005-08-18 | Seth Pawan | Modified release formulations of at least one form of tramadol |
US8128957B1 (en) * | 2002-02-21 | 2012-03-06 | Valeant International (Barbados) Srl | Modified release compositions of at least one form of tramadol |
JP5069395B2 (ja) * | 2002-02-21 | 2012-11-07 | ヴァレアント インターナショナル (バルバドス) エスアールエル | トラマドールの少なくとも1つの形の放出が改良された医薬組成物 |
KR20050086409A (ko) * | 2002-08-15 | 2005-08-30 | 유로-셀티크 소시에떼 아노뉨 | 약학 조성물 |
CN100500130C (zh) * | 2003-01-23 | 2009-06-17 | 株式会社太平洋 | 缓释制剂及其制备方法 |
US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
US20050053669A1 (en) * | 2003-09-05 | 2005-03-10 | Boehringer Ingelheim International Gmbh | Administration form for the oral application of poorly soluble acidic and amphorteric drugs |
DE10341414A1 (de) * | 2003-09-05 | 2005-03-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Oral zu applizierende Darreichungsform für schwerlösliche saure und amphotere Wirkstoffe |
CA2541371C (en) * | 2003-10-03 | 2014-12-16 | Atul M. Mehta | Extended release formulations of opioids and method of use thereof |
US8163114B2 (en) * | 2004-04-07 | 2012-04-24 | New Jersey Institute Of Technology | Netshape manufacturing processes and compositions |
CA2572928A1 (en) * | 2004-07-22 | 2006-02-26 | Amorepacific Corporation | Sustained-release preparations containing topiramate and the producing method thereof |
WO2006028830A2 (en) | 2004-09-01 | 2006-03-16 | Euro-Celtique S.A. | Opioid dosage forms having dose proportional steady state cave and auc and less than dose proportional single dose cmax |
RU2401125C2 (ru) | 2004-12-27 | 2010-10-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Способ стабилизации лекарственного средства против деменции |
US20060246003A1 (en) * | 2004-12-27 | 2006-11-02 | Eisai Co. Ltd. | Composition containing anti-dementia drug |
US20070129402A1 (en) * | 2004-12-27 | 2007-06-07 | Eisai Research Institute | Sustained release formulations |
SI1915137T1 (sl) * | 2005-08-10 | 2013-12-31 | Add Advanced Drug Delivery Technologies, Ltd. | Pripravek z nadzorovanim sproščanjem za peroralno dajanje |
CA2628031C (en) * | 2005-11-10 | 2013-03-05 | Circ Pharma Research And Development Limited | Once-daily administration of central nervous system drugs |
US20070185145A1 (en) * | 2006-02-03 | 2007-08-09 | Royds Robert B | Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same |
US20070264346A1 (en) * | 2006-02-16 | 2007-11-15 | Flamel Technologies | Multimicroparticulate pharmaceutical forms for oral administration |
US20070190141A1 (en) * | 2006-02-16 | 2007-08-16 | Aaron Dely | Extended release opiate composition |
US20070264335A1 (en) * | 2006-05-09 | 2007-11-15 | Sherman Bernard C | Modified release tablets comprising tramadol |
US20080181932A1 (en) * | 2007-01-30 | 2008-07-31 | Drugtech Corporation | Compositions for oral delivery of pharmaceuticals |
CA2678367C (en) * | 2007-03-02 | 2014-07-08 | Farnam Companies, Inc. | Sustained release compositions using wax-like materials |
PL2187873T3 (pl) | 2007-08-13 | 2019-01-31 | Abuse Deterrent Pharmaceutical Llc | Leki odporne na nadużywanie, metoda stosowania i metoda wytwarzania |
CN101095666B (zh) * | 2007-08-14 | 2010-10-06 | 石药集团欧意药业有限公司 | 一种盐酸曲马多缓释片剂及其制备方法 |
CZ300468B6 (cs) * | 2007-09-20 | 2009-05-27 | Zentiva, A. S | Léková forma obsahující tramadol s kontrolovaným uvolnováním po dobu 24 hodin a zpusob její prípravy |
US20100285119A1 (en) * | 2008-01-11 | 2010-11-11 | Jubilant Organosys Ltd. | Multiparticulate Extended Release Pharmaceutical Composition Of Carbamazepine And Process For Manufacturing The Same |
US20100003322A1 (en) * | 2008-07-03 | 2010-01-07 | Lai Felix S | Enteric coated hydrophobic matrix formulation |
US10668012B2 (en) * | 2008-09-04 | 2020-06-02 | Farnam Companies, Inc. | Chewable sustained release formulations |
FR2938431B1 (fr) * | 2008-11-14 | 2013-12-20 | Debregeas Et Associes Pharma | Nouvelle composition a base d'acide gamma-hydroxybutyrique |
ES2602604T3 (es) | 2008-11-18 | 2017-02-21 | Ucb Biopharma Sprl | Formulaciones de liberación prolongada que comprenden un derivado de 2-oxo-1-pirrolidina |
US20100233259A1 (en) * | 2008-12-12 | 2010-09-16 | Pascal Grenier | Dosage form of ropinirole |
FR2949062B1 (fr) | 2009-08-12 | 2011-09-02 | Debregeas Et Associes Pharma | Nouvelles formulations pharmaceutiques contre le mesusage des medicaments |
FR2949061B1 (fr) | 2009-08-12 | 2013-04-19 | Debregeas Et Associes Pharma | Microgranules flottants |
BR112013000190A2 (pt) | 2010-07-06 | 2017-11-07 | Gruenenthal Gmbh | formas de dosagem de retenção gástrica compreendendo um análogo de gaba e um opioide |
BR112015000320B1 (pt) | 2012-07-12 | 2023-03-07 | SpecGx LLC | Composições farmacêuticas dissuasivas de abuso e seu processo de preparação |
US11571390B2 (en) | 2013-03-15 | 2023-02-07 | Othemo Life Sciences, Inc. | Abuse deterrent compositions and methods of use |
US10729685B2 (en) | 2014-09-15 | 2020-08-04 | Ohemo Life Sciences Inc. | Orally administrable compositions and methods of deterring abuse by intranasal administration |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5093200A (en) * | 1985-10-23 | 1992-03-03 | Eisai Co., Ltd. | Multilayer sustained release granule |
US5395626A (en) * | 1994-03-23 | 1995-03-07 | Ortho Pharmaceutical Corporation | Multilayered controlled release pharmaceutical dosage form |
WO1995014460A1 (en) * | 1993-11-23 | 1995-06-01 | Euro-Celtique S.A. | Opioid formulations for treating pain |
Family Cites Families (9)
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US4415547A (en) * | 1982-06-14 | 1983-11-15 | Sterling Drug Inc. | Sustained-release pharmaceutical tablet and process for preparation thereof |
US5026560A (en) * | 1987-01-29 | 1991-06-25 | Takeda Chemical Industries, Ltd. | Spherical granules having core and their production |
US5344657A (en) * | 1988-04-27 | 1994-09-06 | Elf Sanofi | Microbeads of diltiazem, a process for their manufacture and a substained-release pharmaceutical composition containing them |
US5260072A (en) * | 1990-08-30 | 1993-11-09 | Mcneil-Ppc, Inc. | Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets |
AU661723B2 (en) * | 1991-10-30 | 1995-08-03 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
US5411745A (en) * | 1994-05-25 | 1995-05-02 | Euro-Celtique, S.A. | Powder-layered morphine sulfate formulations |
DE4428444A1 (de) * | 1994-08-11 | 1996-02-15 | Dresden Arzneimittel | Verwendung von Selegilin zur Behandlung von epileptischen Erkrankungen |
US5567441A (en) * | 1995-03-24 | 1996-10-22 | Andrx Pharmaceuticals Inc. | Diltiazem controlled release formulation |
DE19630035A1 (de) * | 1996-07-25 | 1998-01-29 | Asta Medica Ag | Tramadol Multiple Unit Formulierungen |
-
1996
- 1996-07-25 DE DE19630035A patent/DE19630035A1/de not_active Withdrawn
-
1997
- 1997-06-19 TW TW086108720A patent/TW495363B/zh not_active IP Right Cessation
- 1997-06-19 ZA ZA9705408A patent/ZA975408B/xx unknown
- 1997-07-18 US US08/896,629 patent/US5955104A/en not_active Expired - Lifetime
- 1997-07-19 PL PL97331387A patent/PL188834B1/pl unknown
- 1997-07-19 IL IL12791597A patent/IL127915A/en not_active IP Right Cessation
- 1997-07-19 ES ES97935532T patent/ES2171268T3/es not_active Expired - Lifetime
- 1997-07-19 HU HU9903053A patent/HU227971B1/hu unknown
- 1997-07-19 JP JP50846698A patent/JP3631762B2/ja not_active Expired - Lifetime
- 1997-07-19 SK SK98-99A patent/SK285300B6/sk not_active IP Right Cessation
- 1997-07-19 DE DE59706441T patent/DE59706441D1/de not_active Expired - Lifetime
- 1997-07-19 DK DK97935532T patent/DK0917463T3/da active
- 1997-07-19 NZ NZ333822A patent/NZ333822A/xx not_active IP Right Cessation
- 1997-07-19 AU AU38491/97A patent/AU737121B2/en not_active Expired
- 1997-07-19 WO PCT/EP1997/003934 patent/WO1998004249A2/de active IP Right Grant
- 1997-07-19 UA UA99021086A patent/UA52679C2/uk unknown
- 1997-07-19 EP EP97935532A patent/EP0917463B1/de not_active Expired - Lifetime
- 1997-07-19 PT PT97935532T patent/PT917463E/pt unknown
- 1997-07-19 CN CN97196651A patent/CN1111402C/zh not_active Expired - Lifetime
- 1997-07-19 EE EEP199900031A patent/EE03742B1/xx unknown
- 1997-07-19 BR BR9710761A patent/BR9710761A/pt not_active Application Discontinuation
- 1997-07-19 RU RU99104404/14A patent/RU2201223C2/ru active
- 1997-07-19 KR KR10-1999-7000586A patent/KR100474793B1/ko not_active IP Right Cessation
- 1997-07-19 CZ CZ0018599A patent/CZ296964B6/cs not_active IP Right Cessation
- 1997-07-19 AT AT97935532T patent/ATE213408T1/de active
- 1997-07-24 CA CA002211284A patent/CA2211284C/en not_active Expired - Lifetime
- 1997-07-25 AR ARP970103383A patent/AR008002A1/es active IP Right Grant
-
1999
- 1999-01-21 NO NO19990261A patent/NO324207B1/no not_active IP Right Cessation
- 1999-02-09 BG BG103158A patent/BG63708B1/bg unknown
- 1999-07-08 US US09/349,564 patent/US6436438B1/en not_active Expired - Lifetime
- 1999-12-22 HK HK99106029A patent/HK1020876A1/xx not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5093200A (en) * | 1985-10-23 | 1992-03-03 | Eisai Co., Ltd. | Multilayer sustained release granule |
WO1995014460A1 (en) * | 1993-11-23 | 1995-06-01 | Euro-Celtique S.A. | Opioid formulations for treating pain |
US5395626A (en) * | 1994-03-23 | 1995-03-07 | Ortho Pharmaceutical Corporation | Multilayered controlled release pharmaceutical dosage form |
US5474786A (en) * | 1994-03-23 | 1995-12-12 | Ortho Pharmaceutical Corporation | Multilayered controlled release pharmaceutical dosage form |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1094790A1 (de) * | 1998-07-07 | 2001-05-02 | Cascade Development, Inc. | Pharmazeutische zubereitung mit verzögerter wirkstofffreisetzung |
EP1094790A4 (de) * | 1998-07-07 | 2003-03-12 | Cascade Dev Inc | Pharmazeutische zubereitung mit verzögerter wirkstofffreisetzung |
EP1424068A1 (de) * | 2002-11-27 | 2004-06-02 | Oramon Arzneimittel GmbH | Verfahren zur Herstellung von Pellets, enthaltend ein tri- oder tetracyclisches Antidepressivum sowie diese Pellets enthaltende pharmazeutische Zubereitungen |
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