WO1998003661A3 - Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components - Google Patents

Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components Download PDF

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Publication number
WO1998003661A3
WO1998003661A3 PCT/US1997/012497 US9712497W WO9803661A3 WO 1998003661 A3 WO1998003661 A3 WO 1998003661A3 US 9712497 W US9712497 W US 9712497W WO 9803661 A3 WO9803661 A3 WO 9803661A3
Authority
WO
WIPO (PCT)
Prior art keywords
components
unique
antimicrobial agents
diagnostic reagents
vaccines based
Prior art date
Application number
PCT/US1997/012497
Other languages
French (fr)
Other versions
WO1998003661A2 (en
WO1998003661A9 (en
Inventor
Rima L W Mcleod
Craig W Roberts
Fiona Roberts
Jennifer J Johnson
Laurens Mets
Original Assignee
Arch Dev Corp
Rima L W Mcleod
Craig W Roberts
Fiona Roberts
Jennifer J Johnson
Laurens Mets
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27487090&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1998003661(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Arch Dev Corp, Rima L W Mcleod, Craig W Roberts, Fiona Roberts, Jennifer J Johnson, Laurens Mets filed Critical Arch Dev Corp
Priority to AU40411/97A priority Critical patent/AU4041197A/en
Priority to EP97937983A priority patent/EP0918868A2/en
Publication of WO1998003661A2 publication Critical patent/WO1998003661A2/en
Publication of WO1998003661A9 publication Critical patent/WO1998003661A9/en
Publication of WO1998003661A3 publication Critical patent/WO1998003661A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56905—Protozoa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

This invention relates to uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.
PCT/US1997/012497 1996-07-19 1997-07-18 Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components WO1998003661A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU40411/97A AU4041197A (en) 1996-07-19 1997-07-18 Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components
EP97937983A EP0918868A2 (en) 1996-07-19 1997-07-18 Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US2220996P 1996-07-19 1996-07-19
US60/022,209 1996-07-19
US77330296A 1996-12-23 1996-12-23
US08/773,302 1996-12-23
US4084997P 1997-03-17 1997-03-17
US60/040,849 1997-03-17
US4962097P 1997-06-13 1997-06-13
US60/049,620 1997-06-13

Publications (3)

Publication Number Publication Date
WO1998003661A2 WO1998003661A2 (en) 1998-01-29
WO1998003661A9 WO1998003661A9 (en) 1998-05-28
WO1998003661A3 true WO1998003661A3 (en) 1998-10-08

Family

ID=27487090

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/012497 WO1998003661A2 (en) 1996-07-19 1997-07-18 Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components

Country Status (2)

Country Link
EP (1) EP0918868A2 (en)
WO (1) WO1998003661A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653531B1 (en) 1998-07-21 2003-11-25 E. I. Du Pont De Nemours And Company Chorismate synthase from plants
US6911331B2 (en) 1998-07-21 2005-06-28 E. I. Du Pont De Nemours And Company Chorismate biosynthesis enzymes
EP1098984A2 (en) * 1998-07-21 2001-05-16 E.I. Du Pont De Nemours And Company Chorismate biosynthesis enzymes
CA2377131A1 (en) * 1999-05-04 2000-11-09 Rima W. Mcleod Anti-microbial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components
DE102006024757A1 (en) * 2006-05-27 2007-12-06 Aesculap Ag & Co. Kg Surgical Obturator
WO2023215819A2 (en) * 2022-05-06 2023-11-09 Whitehead Institute For Biomedical Research Antiparasitic agents and methods

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0135108A2 (en) * 1983-08-12 1985-03-27 Rockefeller University Nucleotide hybridization assay for protozoan parasites
WO1991018092A1 (en) * 1990-05-23 1991-11-28 University Of Maryland At Baltimore Acid-tolerant salmonella typhi, double aro mutants thereof and use as an oral vaccine for typhoid fever
WO1992000734A1 (en) * 1990-07-11 1992-01-23 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce Treatment of a microbial infection with drugs containing para-acetamidobenzoic acid
WO1993013197A1 (en) * 1991-12-31 1993-07-08 Picower Institute For Medical Research Heme polymerase and method for treating malaria
WO1993013740A2 (en) * 1991-12-31 1993-07-22 Worcester Foundation For Experimental Biology Antiparasitic oligonucleotides active against drug resistant malaria
WO1995010526A1 (en) * 1993-10-14 1995-04-20 The University Of Pennsylvania Plasmodium falciparum ribonucleotide reductase, encoding dna, and inhibitors
WO1995019706A1 (en) * 1994-01-24 1995-07-27 The Johns Hopkins University Inhibitors of fatty acid synthesis as antimicrobial agents

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0135108A2 (en) * 1983-08-12 1985-03-27 Rockefeller University Nucleotide hybridization assay for protozoan parasites
WO1991018092A1 (en) * 1990-05-23 1991-11-28 University Of Maryland At Baltimore Acid-tolerant salmonella typhi, double aro mutants thereof and use as an oral vaccine for typhoid fever
WO1992000734A1 (en) * 1990-07-11 1992-01-23 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce Treatment of a microbial infection with drugs containing para-acetamidobenzoic acid
WO1993013197A1 (en) * 1991-12-31 1993-07-08 Picower Institute For Medical Research Heme polymerase and method for treating malaria
WO1993013740A2 (en) * 1991-12-31 1993-07-22 Worcester Foundation For Experimental Biology Antiparasitic oligonucleotides active against drug resistant malaria
WO1995010526A1 (en) * 1993-10-14 1995-04-20 The University Of Pennsylvania Plasmodium falciparum ribonucleotide reductase, encoding dna, and inhibitors
WO1995019706A1 (en) * 1994-01-24 1995-07-27 The Johns Hopkins University Inhibitors of fatty acid synthesis as antimicrobial agents

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
A. HEHL ET AL.: "The WashU-Merck-Stanford-NIH Toxoplasma EST project", EMBL SEQUENCE DATABASE, 13 April 1996 (1996-04-13), HEIDELBERG, FRG, XP002069078 *
A.B. CLARKSON JR. ET AL.: "Respiration of bloodstream forms of the parasite Trypanosoma brucei brucei is dependent on a plant-like alternative oxidase", J. BIOL. CHEM., vol. 264, no. 30, 25 October 1989 (1989-10-25), AM. SOC. BIOCHEM. MOL.BIOL.,INC.,BALTIMORE,US, pages 17770 - 17776, XP002069081 *
D.H. WILLIAMSON ET AL.: "The evolutionary origin of the 35kb circular DNA od Plasmodium falciparum: new evidence supports a possible rhodophyte ancestry", MOLECULAR & GENERAL GENETICS, vol. 243, 1994, SPRINGER INTERNATIONAL, AMSTERDAM, NL, pages 249 - 252, XP002069085 *
G.I. MACFADDEN ET AL.: "Plastid in human parasites", NATURE, vol. 381, 6 June 1996 (1996-06-06), MACMILLAN JOURNALS LTD., LONDON,UK, pages 482, XP002069083 *
I. ITTARAT ET AL.: "Effects of Atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenase", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 39, no. 2, February 1995 (1995-02-01), AM. SOC. MICROBIOL., WASHINGTON, D.C., US, pages 325 - 328, XP002069079 *
J.H.P. HACKSTEIN ET AL.: "Parasitic apicomplexans harbor a chlorophyll a-D1 complex, the potential target for therapeutic triazine", PARASITOLOGY RESEARCH, vol. 81, 1995, SPRINGER VERLAG, BERLIN,BRD, pages 207 - 216, XP002069178 *
L. MCINTOSH: "Molecular Biology of the alternative oxidase", PLANT PHYSIOLOGY, vol. 105, 1994, WILLIAMS & WILKINS, BETHESDA, MD, US, pages 781 - 786, XP002069082 *
R.J.M. WILSON ET AL.: "Malaria and other Apicomplexans: The "Plant Connection"", INFECTIOUS AGENTS AND DISEASE, vol. 3, no. 29, 1994, RAVEN PRESS, LTD. NEW YORK, US, pages 29 - 37, XP002069084 *
W.E. GUTTERIDGE ET AL.: "Conversion of dihydroorotate to orotate in parasitic protozoa", BIOCHIMICA BIOPHYSICA ACTA, vol. 582, no. 3, 1 February 1979 (1979-02-01), ELSEVIER SCIENCE, AMSTERDAM, NL, pages 390 - 401, XP002069080 *

Also Published As

Publication number Publication date
WO1998003661A2 (en) 1998-01-29
EP0918868A2 (en) 1999-06-02

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