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Publication numberWO1998003661 A3
Publication typeApplication
Application numberPCT/US1997/012497
Publication date8 Oct 1998
Filing date18 Jul 1997
Priority date19 Jul 1996
Also published asEP0918868A2, WO1998003661A2
Publication numberPCT/1997/12497, PCT/US/1997/012497, PCT/US/1997/12497, PCT/US/97/012497, PCT/US/97/12497, PCT/US1997/012497, PCT/US1997/12497, PCT/US1997012497, PCT/US199712497, PCT/US97/012497, PCT/US97/12497, PCT/US97012497, PCT/US9712497, WO 1998/003661 A3, WO 1998003661 A3, WO 1998003661A3, WO 9803661 A3, WO 9803661A3, WO-A3-1998003661, WO-A3-9803661, WO1998/003661A3, WO1998003661 A3, WO1998003661A3, WO9803661 A3, WO9803661A3
InventorsRima L W Mcleod, Craig W Roberts, Fiona Roberts, Jennifer J Johnson, Laurens Mets
ApplicantArch Dev Corp, Rima L W Mcleod, Craig W Roberts, Fiona Roberts, Jennifer J Johnson, Laurens Mets
Export CitationBiBTeX, EndNote, RefMan
External Links: Patentscope, Espacenet
Antimicrobial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components
WO 1998003661 A3
Abstract
This invention relates to uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
WO1991018092A1 *22 May 199128 Nov 1991University Of Maryland At BaltimoreAcid-tolerant salmonella typhi, double aro mutants thereof and use as an oral vaccine for typhoid fever
WO1992000734A1 *11 Jul 199123 Jan 1992The United States Of America, As Represented By The Secretary, U.S. Department Of CommerceTreatment of a microbial infection with drugs containing para-acetamidobenzoic acid
WO1993013197A1 *29 Dec 19928 Jul 1993Picower Institute For Medical ResearchHeme polymerase and method for treating malaria
WO1993013740A2 *31 Dec 199222 Jul 1993Worcester Foundation For Experimental BiologyAntiparasitic oligonucleotides active against drug resistant malaria
WO1995010526A1 *7 Oct 199420 Apr 1995The University Of PennsylvaniaPlasmodium falciparum ribonucleotide reductase, encoding dna, and inhibitors
WO1995019706A1 *24 Jan 199527 Jul 1995The Johns Hopkins UniversityInhibitors of fatty acid synthesis as antimicrobial agents
EP0135108A2 *7 Aug 198427 Mar 1985Rockefeller UniversityNucleotide hybridization assay for protozoan parasites
Non-Patent Citations
Reference
1 *A. HEHL ET AL.: "The WashU-Merck-Stanford-NIH Toxoplasma EST project", EMBL SEQUENCE DATABASE, 13 April 1996 (1996-04-13), HEIDELBERG, FRG, XP002069078
2 *A.B. CLARKSON JR. ET AL.: "Respiration of bloodstream forms of the parasite Trypanosoma brucei brucei is dependent on a plant-like alternative oxidase", J. BIOL. CHEM., vol. 264, no. 30, 25 October 1989 (1989-10-25), AM. SOC. BIOCHEM. MOL.BIOL.,INC.,BALTIMORE,US, pages 17770 - 17776, XP002069081
3 *D.H. WILLIAMSON ET AL.: "The evolutionary origin of the 35kb circular DNA od Plasmodium falciparum: new evidence supports a possible rhodophyte ancestry", MOLECULAR & GENERAL GENETICS, vol. 243, 1994, SPRINGER INTERNATIONAL, AMSTERDAM, NL, pages 249 - 252, XP002069085
4 *G.I. MACFADDEN ET AL.: "Plastid in human parasites", NATURE, vol. 381, 6 June 1996 (1996-06-06), MACMILLAN JOURNALS LTD., LONDON,UK, pages 482, XP002069083
5 *I. ITTARAT ET AL.: "Effects of Atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenase", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 39, no. 2, February 1995 (1995-02-01), AM. SOC. MICROBIOL., WASHINGTON, D.C., US, pages 325 - 328, XP002069079
6 *J.H.P. HACKSTEIN ET AL.: "Parasitic apicomplexans harbor a chlorophyll a-D1 complex, the potential target for therapeutic triazine", PARASITOLOGY RESEARCH, vol. 81, 1995, SPRINGER VERLAG, BERLIN,BRD, pages 207 - 216, XP002069178
7 *L. MCINTOSH: "Molecular Biology of the alternative oxidase", PLANT PHYSIOLOGY, vol. 105, 1994, WILLIAMS & WILKINS, BETHESDA, MD, US, pages 781 - 786, XP002069082
8 *R.J.M. WILSON ET AL.: "Malaria and other Apicomplexans: The "Plant Connection"", INFECTIOUS AGENTS AND DISEASE, vol. 3, no. 29, 1994, RAVEN PRESS, LTD. NEW YORK, US, pages 29 - 37, XP002069084
9 *W.E. GUTTERIDGE ET AL.: "Conversion of dihydroorotate to orotate in parasitic protozoa", BIOCHIMICA BIOPHYSICA ACTA, vol. 582, no. 3, 1 February 1979 (1979-02-01), ELSEVIER SCIENCE, AMSTERDAM, NL, pages 390 - 401, XP002069080
Classifications
International ClassificationC12N9/90, G01N33/569, C12N9/88, A61K38/00, A61K39/002
Cooperative ClassificationC12N9/88, A61K39/002, A61K38/00, C12N9/90, G01N33/56905
European ClassificationC12N9/88, G01N33/569B, C12N9/90, A61K39/002
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