WO1998003205A3 - Enhanced ultrasound contrast imaging using inhaled gases - Google Patents

Enhanced ultrasound contrast imaging using inhaled gases Download PDF

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Publication number
WO1998003205A3
WO1998003205A3 PCT/US1997/012354 US9712354W WO9803205A3 WO 1998003205 A3 WO1998003205 A3 WO 1998003205A3 US 9712354 W US9712354 W US 9712354W WO 9803205 A3 WO9803205 A3 WO 9803205A3
Authority
WO
WIPO (PCT)
Prior art keywords
ultrasound contrast
contrast agent
contrast imaging
enhanced ultrasound
inhaled gases
Prior art date
Application number
PCT/US1997/012354
Other languages
French (fr)
Other versions
WO1998003205A2 (en
Inventor
Steven C Quay
Original Assignee
Sonus Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sonus Pharma Inc filed Critical Sonus Pharma Inc
Priority to AU36652/97A priority Critical patent/AU3665297A/en
Publication of WO1998003205A2 publication Critical patent/WO1998003205A2/en
Publication of WO1998003205A3 publication Critical patent/WO1998003205A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

Ultrasound imaging of the left cardiac chambers of the heart and other tissues is enhanced by inhalation of a gas or gas mixture during intravenous injection of an ultrasound contrast agent. Increased concentration of the inhaled gas in the lungs suppresses outgassing of the contrast agent in the lungs, maintaining high concentrations of the contrast agent in blood flowing to the left heart and other tissues.
PCT/US1997/012354 1996-07-19 1997-07-16 Enhanced ultrasound contrast imaging using inhaled gases WO1998003205A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU36652/97A AU3665297A (en) 1996-07-19 1997-07-16 Enhanced ultrasound contrast imaging using inhaled gases

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2252896P 1996-07-19 1996-07-19
US60/022,528 1996-07-19
US89308197A 1997-07-15 1997-07-15
US08/893,081 1997-07-15

Publications (2)

Publication Number Publication Date
WO1998003205A2 WO1998003205A2 (en) 1998-01-29
WO1998003205A3 true WO1998003205A3 (en) 1998-03-05

Family

ID=26696032

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/012354 WO1998003205A2 (en) 1996-07-19 1997-07-16 Enhanced ultrasound contrast imaging using inhaled gases

Country Status (2)

Country Link
AU (1) AU3665297A (en)
WO (1) WO1998003205A2 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005819A1 (en) * 1991-09-17 1993-04-01 Sonus Pharmaceuticals, Inc Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
WO1993006869A1 (en) * 1991-10-04 1993-04-15 Mallinckrodt Medical, Inc. Gaseous ultrasound contrast agents
WO1995023615A1 (en) * 1994-03-01 1995-09-08 Holmes, Michael, John Gas-containing microcapsules useful as contrast agents for diagnostic imaging
WO1996035457A1 (en) * 1995-05-12 1996-11-14 Board Of Regents Of The University Of Nebraska Suspended ultra-sound induced microbubble cavitation imaging
WO1996038181A1 (en) * 1995-05-31 1996-12-05 Board Of Regents Of The University Of Nebraska Sonicated dextrose-albumin ultrasound contrast agent, containing perfluorobutane
WO1996038180A1 (en) * 1995-05-30 1996-12-05 Board Of Regents Of The University Of Nebraska Ultrasound contrast agents, containing perfluorocarbon in dextrose-albumin microbubbles
WO1996040288A1 (en) * 1995-06-07 1996-12-19 Mallinckrodt Medical, Inc. Gaseous ultrasound contrast agents and method therefor

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005819A1 (en) * 1991-09-17 1993-04-01 Sonus Pharmaceuticals, Inc Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
WO1993006869A1 (en) * 1991-10-04 1993-04-15 Mallinckrodt Medical, Inc. Gaseous ultrasound contrast agents
WO1995023615A1 (en) * 1994-03-01 1995-09-08 Holmes, Michael, John Gas-containing microcapsules useful as contrast agents for diagnostic imaging
WO1996035457A1 (en) * 1995-05-12 1996-11-14 Board Of Regents Of The University Of Nebraska Suspended ultra-sound induced microbubble cavitation imaging
WO1996038180A1 (en) * 1995-05-30 1996-12-05 Board Of Regents Of The University Of Nebraska Ultrasound contrast agents, containing perfluorocarbon in dextrose-albumin microbubbles
WO1996038181A1 (en) * 1995-05-31 1996-12-05 Board Of Regents Of The University Of Nebraska Sonicated dextrose-albumin ultrasound contrast agent, containing perfluorobutane
WO1996040288A1 (en) * 1995-06-07 1996-12-19 Mallinckrodt Medical, Inc. Gaseous ultrasound contrast agents and method therefor

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHORTKOFF BS ET AL: "Pharmacokinetics do not explain the absence of an anesthetic effect of perfluoropropane or perfluoropentane.", ANESTH ANALG, AUG 1994, VOL. 79, NO. 2, PAGE(S) 234-7, XP002050883 *
EGER, E. I II ET AL.: "Molecular properties of the "ideal" inhaled anesthetic: Studies of fluorinated methanes, ethanes, propanes, and butanes", ANESTH. ANALG. (N. Y.), 1994, VOL. 79, NO. 2, PAGES 245-51, XP002050882 *
FANG Z ET AL: "Convulsant activity of nonanesthetic gas combinations.", ANESTH ANALG, MAR 1997, VOL. 84, NO. 3, PAGE(S) 634-40, XP002050886 *
FENG XIE ET AL: "PERFLUOROPROPANE ENHANCED SONICATED DEXTROSE ALBUMIN PRODUCES VISUALLY APPARENT CONSISTENT MYOCARDIAL OPACIFICATION WITH PHYSIOLOGIC WASHOUT AND MINIMAL HEMODYNAMIC CHANGES FOLLOWING VENOUS INJECTION", CIRCULATION, vol. 90, no. 4, PART 02, 14 November 1994 (1994-11-14), pages I-69, XP000577055 *
J.H. WIBLE JR. ET AL.: "Effects of inspired gas on the efficacy of Albunex(R) in dogs", CIRCULATION, vol. 88, no. 4, PART 02, October 1993 (1993-10-01), pages I-401, XP002050884 *
KANDEL L ET AL: "Nonanesthetics can suppress learning.", ANESTH ANALG, FEB 1996, VOL. 82, NO. 2, PAGE(S) 321-6, XP002050885 *
PORTER T R ET AL: "NONINVASIVE IDENTIFICATION OF ACUTE MYOCARDIAL ISCHEMIA AND REPERFUSION WITH CONTRAST ULTRASOUND USING INTRAVENOUS PERFLUOROPROPANE-EXPOSED SONICATED DEXTROSE ALBUMIN", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 26, no. 1, 1 July 1995 (1995-07-01), pages 33 - 40, XP000590865 *

Also Published As

Publication number Publication date
AU3665297A (en) 1998-02-10
WO1998003205A2 (en) 1998-01-29

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