WO1998002146A3 - Chemo-mechanical expansion delivery system - Google Patents

Chemo-mechanical expansion delivery system Download PDF

Info

Publication number
WO1998002146A3
WO1998002146A3 PCT/US1997/012704 US9712704W WO9802146A3 WO 1998002146 A3 WO1998002146 A3 WO 1998002146A3 US 9712704 W US9712704 W US 9712704W WO 9802146 A3 WO9802146 A3 WO 9802146A3
Authority
WO
WIPO (PCT)
Prior art keywords
biologically active
biological environment
container
chemo
delivery system
Prior art date
Application number
PCT/US1997/012704
Other languages
French (fr)
Other versions
WO1998002146A2 (en
Inventor
Eyal S Ron
Original Assignee
Gel Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gel Sciences Inc filed Critical Gel Sciences Inc
Priority to JP10506332A priority Critical patent/JPH11513041A/en
Priority to EP97938003A priority patent/EP0853474A2/en
Publication of WO1998002146A2 publication Critical patent/WO1998002146A2/en
Publication of WO1998002146A3 publication Critical patent/WO1998002146A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Abstract

System for delivery of a biologically active substance into an environment. The container is comprised of a single member or two mated members and defines first and second compartments. The container includes pores in at least a portion of the container defining the first compartment. The first compartment contains a polymer gel network which undergoes a volume expansion in response to an environmental condition which varies in the biological environment. The second compartment contains an effective amount of a biologically active compound and may include at least one passageway communicating with the biological environment. Drug delivery is initiated and continues only when the appropriate environmental condition or trigger is met, whereupon volume expansion of the polymer gel network causes the biologically active compound to be discharged into the biological environment.
PCT/US1997/012704 1996-07-16 1997-07-16 Chemo-mechanical expansion delivery system WO1998002146A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP10506332A JPH11513041A (en) 1996-07-16 1997-07-16 Chemical-mechanical expansion supply device
EP97938003A EP0853474A2 (en) 1996-07-16 1997-07-16 Chemo-mechanical expansion delivery system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2209296P 1996-07-16 1996-07-16
US60/022,092 1996-07-16

Publications (2)

Publication Number Publication Date
WO1998002146A2 WO1998002146A2 (en) 1998-01-22
WO1998002146A3 true WO1998002146A3 (en) 1998-03-12

Family

ID=21807776

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/012704 WO1998002146A2 (en) 1996-07-16 1997-07-16 Chemo-mechanical expansion delivery system

Country Status (4)

Country Link
EP (1) EP0853474A2 (en)
JP (1) JPH11513041A (en)
CA (1) CA2230656A1 (en)
WO (1) WO1998002146A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8052982B2 (en) 1998-07-20 2011-11-08 Peptech Animal Health Pty Limited Bioimplant formulation comprising lecithin and stearin
US7910124B2 (en) 2004-02-06 2011-03-22 Georgia Tech Research Corporation Load bearing biocompatible device
WO2005077013A2 (en) 2004-02-06 2005-08-25 Georgia Tech Research Corporation Surface directed cellular attachment
NZ543314A (en) * 2005-10-28 2007-08-31 Interag A delivery system where the driving substance contains the active component
EP2757964B1 (en) 2011-05-26 2016-05-04 Cartiva, Inc. Tapered joint implant and related tools
EP3892241A1 (en) 2015-03-31 2021-10-13 Cartiva, Inc. Drill bit for carpometacarpal implant
CA2981061A1 (en) 2015-03-31 2016-10-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
CA2981074C (en) 2015-04-14 2023-03-28 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
CN108366960B (en) * 2015-10-23 2022-04-19 国立大学法人东京医科齿科大学 Drug delivery device

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034756A (en) * 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US4180073A (en) * 1977-08-29 1979-12-25 Alza Corporation Device for delivering drug to biological environment
US4235236A (en) * 1979-02-12 1980-11-25 Alza Corporation Device for dispensing drug by combined diffusional and osmotic operations
WO1992005775A1 (en) * 1990-09-28 1992-04-16 Pfizer Inc. Dispensing device containing a hydrophobic medium
WO1996002276A2 (en) * 1994-07-18 1996-02-01 Gel Sciences, Inc. Novel polymer gel networks and methods of use
WO1996040082A2 (en) * 1995-06-07 1996-12-19 Gel Sciences, Inc. Apparatus and method for delivering a biologically active compound into a biological environment

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034756A (en) * 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US4180073A (en) * 1977-08-29 1979-12-25 Alza Corporation Device for delivering drug to biological environment
US4235236A (en) * 1979-02-12 1980-11-25 Alza Corporation Device for dispensing drug by combined diffusional and osmotic operations
WO1992005775A1 (en) * 1990-09-28 1992-04-16 Pfizer Inc. Dispensing device containing a hydrophobic medium
WO1996002276A2 (en) * 1994-07-18 1996-02-01 Gel Sciences, Inc. Novel polymer gel networks and methods of use
WO1996040082A2 (en) * 1995-06-07 1996-12-19 Gel Sciences, Inc. Apparatus and method for delivering a biologically active compound into a biological environment

Also Published As

Publication number Publication date
JPH11513041A (en) 1999-11-09
CA2230656A1 (en) 1998-01-22
EP0853474A2 (en) 1998-07-22
WO1998002146A2 (en) 1998-01-22

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