WO1997044657A1 - Blood gas/electrolyte calibrator and method for use - Google Patents
Blood gas/electrolyte calibrator and method for use Download PDFInfo
- Publication number
- WO1997044657A1 WO1997044657A1 PCT/US1997/008581 US9708581W WO9744657A1 WO 1997044657 A1 WO1997044657 A1 WO 1997044657A1 US 9708581 W US9708581 W US 9708581W WO 9744657 A1 WO9744657 A1 WO 9744657A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ion
- calcium
- solution
- acetate
- calibrator
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/492—Determining multiple analytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2496/00—Reference solutions for assays of biological material
- G01N2496/70—Blood gas control solutios containing dissolved oxygen, bicarbonate and the like
Definitions
- This invention relates to aqueous solutions containing buffers and electrolytes adjusted to specific levels for calibration or quality control of chemical analyzers.
- this invention relates to a solution which has the specific parameters for the calibration and quality control of both blood gas and ion selective electrode instrumentation.
- Analytical devices for determining various parameters in whole blood with the aid of ion-selective electrodes have been used in intensive care units and in the field of anesthetics.
- Various blood chemistries such as carbon dioxide, pH, K + , Na + , and Ca ++ , can be measured using ion selective electrodes.
- An ion selective electrode consists of an electrochemical half-cell (an internal electrolyte solution and an internal reference electrode) and a sensing membrane. These types of electrodes are used to measure a specific ion in the presence of other ions in bodily fluids, such as whole blood.
- a set of calibration solutions are used to calibrate the electrodes.
- control solutions are used with clinical chemical analyzers to verify the accuracy of tests run.
- control solutions used to verify performance of medical instruments should have essentially the same constituents as those present in the fluid that is subjected to analysis.
- the present invention relates to calibrating and control solutions for instrumentation that measures both blood gas and electrolytes, and to a method of using such solutions in instruments that measure blood gases and electrolytes.
- this invention relates to a method for stabilizing free calcium ions in blood gas/electrolyte instrument control solutions containing bicarbonate as a buffer for pH and/or source of carbon dioxide and calcium as an electrolyte.
- Precipitation of calcium carbonate in the calibrator or control solution is prevented by addition of protecting species, usually ions, which protect the calcium cations from contact with the carbonate ions.
- the preferred protecting species is acetate.
- the method of this invention for stabilizing free calcium ion solutions used as controls with or to calibrate instruments that measure blood gases and electrolytes is practiced in solutions prepared by conventional manufacturing techniques using readily available materials.
- solutions made by the method of this invention can be used either as standard controls to verify the accuracy of results or to calibrate the instruments, for convenience both types of solutions are referred to herein as "calibrator solutions.”
- a typical calibrator solution within the contemplation of this invention is prepared by simply combining in appropriate relative proportions a buffer, electrolytes, and other standard auxiliary reagents, such as a detergent used as a wetting agent.
- the approximate pH of the solution is provided by combining the acid and salt forms of the buffer used, normally to a pH of about 7.0 to 7.4.
- the solution is tonometered with oxygen and CO 2 mixed with nitrogen or other suitable gas to produce the desired level of oxygen, CO 2 , and pH for the solution.
- the electrolytes used in the control solution are generally selected from sodium (Na + and/or NaCL), potassium (K + and/or KC1), calcium (Ca +2 and/or CaCl 2 ), and chloride. Lithium can also be added.
- Table I contains a list representative of compounds that can be added to calibrator solutions in the method of this invention as protecting species, or as a source of protecting species, to prevent the combination of free calcium ions with carbonate ion in formation of calcium carbonate.
- the amount of the protecting species added depends on the levels of both calcium and carbon dioxide desired in the calibrator solution, and can readily be determined by one skilled in the art.
- the calcium ions are preferably protected by addition to the calibrator solution of acetate ion as the protecting species, most preferably, in the form of sodium acetate.
- Various solutions can be prepared for as many calibration points as necessary for the instrumentation.
- the amount of calcium in a solution can also be assayed by adding incremental amounts of the protecting species of the invention to a solution containing an unknown amount of calcium and determining the amount of protecting species corresponding to the point at which formation of calcium carbonate is detected. From this information, the amount of calcium ion in the solution can be calculated using known methods of analytical chemistry.
- the calibrator solution is generally filtered, placed into gas tight containers, such as laminate bags of aluminum foil, and stored in the containers without a gaseous headspace, so that in the final container no further equilibrium with gases will take place.
- gas tight containers such as laminate bags of aluminum foil
- the final solution is not affected by changes in temperature or pressure.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU31357/97A AU3135797A (en) | 1996-05-20 | 1997-05-19 | Blood gas/electrolyte calibrator and method for use |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65062296A | 1996-05-20 | 1996-05-20 | |
US08/650,622 | 1996-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997044657A1 true WO1997044657A1 (en) | 1997-11-27 |
Family
ID=24609629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/008581 WO1997044657A1 (en) | 1996-05-20 | 1997-05-19 | Blood gas/electrolyte calibrator and method for use |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU3135797A (en) |
WO (1) | WO1997044657A1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4945062A (en) * | 1988-06-15 | 1990-07-31 | Bionostics Incorporated | Control for blood gas/calcium analysis instrumentation |
US5296217A (en) * | 1992-06-15 | 1994-03-22 | Indiana University Foundation | Methods for preventing dental calculus in domestic animals |
-
1997
- 1997-05-19 AU AU31357/97A patent/AU3135797A/en not_active Abandoned
- 1997-05-19 WO PCT/US1997/008581 patent/WO1997044657A1/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4945062A (en) * | 1988-06-15 | 1990-07-31 | Bionostics Incorporated | Control for blood gas/calcium analysis instrumentation |
US5296217A (en) * | 1992-06-15 | 1994-03-22 | Indiana University Foundation | Methods for preventing dental calculus in domestic animals |
Also Published As
Publication number | Publication date |
---|---|
AU3135797A (en) | 1997-12-09 |
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