WO1997043962A1 - Procedes et appareils permettant d'exprimer des fluides biologiques d'une incision - Google Patents

Procedes et appareils permettant d'exprimer des fluides biologiques d'une incision Download PDF

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Publication number
WO1997043962A1
WO1997043962A1 PCT/US1997/008380 US9708380W WO9743962A1 WO 1997043962 A1 WO1997043962 A1 WO 1997043962A1 US 9708380 W US9708380 W US 9708380W WO 9743962 A1 WO9743962 A1 WO 9743962A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
stimulator
incision
skm
stimulator member
Prior art date
Application number
PCT/US1997/008380
Other languages
English (en)
Inventor
Joel S. Douglas
Jeffrey N. Roe
Henry M. Grage
Original Assignee
Mercury Diagnostics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mercury Diagnostics, Inc. filed Critical Mercury Diagnostics, Inc.
Priority to DE19781044T priority Critical patent/DE19781044B4/de
Priority to AU32067/97A priority patent/AU3206797A/en
Priority to IL12442697A priority patent/IL124426A/xx
Priority to JP54260097A priority patent/JP3494660B2/ja
Priority to GB9810081A priority patent/GB2322561B/en
Priority to AT97927654T priority patent/ATE458448T1/de
Priority to EP97927654A priority patent/EP0955914B1/fr
Priority to DE29723371U priority patent/DE29723371U1/de
Priority to DE69739783T priority patent/DE69739783D1/de
Publication of WO1997043962A1 publication Critical patent/WO1997043962A1/fr
Priority to DK199800647A priority patent/DK64798A/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
    • A61B5/15188—Constructional features of reusable driving devices
    • A61B5/15192—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing
    • A61B5/15194—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing fully automatically retracted, i.e. the retraction does not require a deliberate action by the user, e.g. by terminating the contact with the patient's skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150068—Means for enhancing collection by tissue compression, e.g. with specially designed surface of device contacting the skin area to be pierced
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150076—Means for enhancing collection by heating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150083—Means for enhancing collection by vibration, e.g. ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150106—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced
    • A61B5/150114—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced by tissue compression, e.g. with specially designed surface of device contacting the skin area to be pierced
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150106—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced
    • A61B5/150122—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced by heating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150106—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced
    • A61B5/150137—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced by vibration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15107—Piercing being assisted by a triggering mechanism
    • A61B5/15109—Fully automatically triggered, i.e. the triggering does not require a deliberate action by the user, e.g. by contact with the patient's skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15107—Piercing being assisted by a triggering mechanism
    • A61B5/15113—Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
    • A61B5/15117—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0295—Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157

Abstract

On prélève un échantillon d'un fluide biologique tel que le sang ou un liquide interstitiel à partir du corps en perçant une partie de la peau de l'utilisateur, de préférence dans une zone autre que le bout du doigt pour produire une incision. Après que l'aiguille (42) a été enlevée de l'incision, on applique une force destinée à enfoncer la peau de sorte qu'un anneau de tissu biologique enfoncé soit formé autour de l'incision, entraînant le gonflement et l'ouverture des lèvres de ladite incision, ce qui exprime les fluides biologiques de l'ouverture créée par cette dernière. Un élément stimulateur (64) est monté à une extrémité d'une enveloppe (40) portant une lancette pour appliquer ladite force. Cet élément stimulateur (64) peut se déplacer par rapport à l'enveloppe, et peut être soit chauffé soit mis en vibrations pour favoriser le mouvement des fluides biologiques.
PCT/US1997/008380 1996-05-17 1997-05-16 Procedes et appareils permettant d'exprimer des fluides biologiques d'une incision WO1997043962A1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DE19781044T DE19781044B4 (de) 1996-05-17 1997-05-16 Verfahren und Vorrichtungen zum Ausdrücken von Körperflüssigkeit aus einem Einstich
AU32067/97A AU3206797A (en) 1996-05-17 1997-05-16 Methods and apparatus for expressing body fluid from an incision
IL12442697A IL124426A (en) 1996-05-17 1997-05-16 Method and apparatus for expressing body fluid from an incision
JP54260097A JP3494660B2 (ja) 1996-05-17 1997-05-16 切開部から体液を絞り出す装置
GB9810081A GB2322561B (en) 1996-05-17 1997-05-16 Methods and apparatus for expressing body fluid from an incision
AT97927654T ATE458448T1 (de) 1996-05-17 1997-05-16 Vorrichtung zur probenahme von körperflüssigkeiten
EP97927654A EP0955914B1 (fr) 1996-05-17 1997-05-16 Appareil de prelevement de liquide organique
DE29723371U DE29723371U1 (de) 1996-05-17 1997-05-16 Vorrichtung zum Ausdrücken von Körperflüssigkeit aus einem Einstich
DE69739783T DE69739783D1 (de) 1996-05-17 1997-05-16 Vorrichtung zur probenahme von körperflüssigkeiten
DK199800647A DK64798A (da) 1996-05-17 1998-05-12 Fremgangsmåde og apparat til udpresning af kropsvæske fra en incision

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US1713396P 1996-05-17 1996-05-17
US60/017,133 1996-05-17
US1991896P 1996-06-14 1996-06-14
US60/019,918 1996-06-14
US2365896P 1996-08-01 1996-08-01
US60/023,658 1996-08-01
US2534096P 1996-09-03 1996-09-03
US60/025,340 1996-09-03
US9212196P 1996-09-16 1996-09-16
US71045696A 1996-09-17 1996-09-17
US08/710,456 1996-09-17
US72707496A 1996-10-08 1996-10-08
US60/092,121 1996-10-08
US08/727,074 1996-10-08

Publications (1)

Publication Number Publication Date
WO1997043962A1 true WO1997043962A1 (fr) 1997-11-27

Family

ID=27567560

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/008380 WO1997043962A1 (fr) 1996-05-17 1997-05-16 Procedes et appareils permettant d'exprimer des fluides biologiques d'une incision

Country Status (5)

Country Link
EP (2) EP0955914B1 (fr)
JP (3) JP3494660B2 (fr)
AT (1) ATE458448T1 (fr)
DE (1) DE69739783D1 (fr)
WO (1) WO1997043962A1 (fr)

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US5951492A (en) * 1996-05-17 1999-09-14 Mercury Diagnostics, Inc. Methods and apparatus for sampling and analyzing body fluid
US5951493A (en) * 1997-05-16 1999-09-14 Mercury Diagnostics, Inc. Methods and apparatus for expressing body fluid from an incision
WO1999055232A1 (fr) * 1998-04-28 1999-11-04 Amira Medical, Inc. Methodes et appareils permettant d'aspirer et de pomper un fluide corporel par une incision
US6015392A (en) * 1996-05-17 2000-01-18 Mercury Diagnostics, Inc. Apparatus for sampling body fluid
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JP3494660B2 (ja) 2004-02-09
JP2003102712A (ja) 2003-04-08
JP2003102711A (ja) 2003-04-08
JP2002503119A (ja) 2002-01-29
ATE458448T1 (de) 2010-03-15
JP3654877B2 (ja) 2005-06-02
EP0955914A4 (fr) 1999-12-29
EP2160981A2 (fr) 2010-03-10
EP2160981A3 (fr) 2010-08-04
EP0955914B1 (fr) 2010-02-24
EP2160981B1 (fr) 2013-04-10
EP0955914A1 (fr) 1999-11-17
DE69739783D1 (de) 2010-04-08

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