WO1997043899A1 - Solution and process for resuscitation and reparation of ischemically damaged tissue - Google Patents
Solution and process for resuscitation and reparation of ischemically damaged tissue Download PDFInfo
- Publication number
- WO1997043899A1 WO1997043899A1 PCT/US1997/008205 US9708205W WO9743899A1 WO 1997043899 A1 WO1997043899 A1 WO 1997043899A1 US 9708205 W US9708205 W US 9708205W WO 9743899 A1 WO9743899 A1 WO 9743899A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- organ
- function
- resuscitation
- solution
- blood flow
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
- A61M2202/0476—Oxygenated solutions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Dentistry (AREA)
- General Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002255657A CA2255657C (en) | 1996-05-17 | 1997-05-16 | Solution and process for resuscitation and reparation of ischemically damaged tissue |
AU30671/97A AU723424B2 (en) | 1996-05-17 | 1997-05-16 | Solution and process for resuscitation and reparation of ischemically damaged tissue |
EP97925571.8A EP1021084B2 (en) | 1996-05-17 | 1997-05-16 | Solution and process for resuscitation and reparation of ischemically damaged tissue |
ES97925571.8T ES2296310T5 (en) | 1996-05-17 | 1997-05-16 | Dissolution and procedure for resuscitation and repair of ischemically damaged tissue |
JP54252797A JP4259614B2 (en) | 1996-05-17 | 1997-05-16 | Solution and method for resuscitation and compensation of ischemic injury tissue |
DE69738184T DE69738184T2 (en) | 1996-05-17 | 1997-05-16 | SOLUTION AND METHOD FOR THE REVIVAL AND HEALING OF ISCHEMICALLY DAMAGED TISSUE |
HK00100972A HK1021925A1 (en) | 1996-05-17 | 2000-02-18 | Solution and process for resuscitation and reparation of ischemically damaged tissue. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/649,200 US5843024A (en) | 1996-05-17 | 1996-05-17 | Solution and process for resuscitation and preparation of ischemically damaged tissue |
US08/649,200 | 1996-05-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997043899A1 true WO1997043899A1 (en) | 1997-11-27 |
Family
ID=24603829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/008205 WO1997043899A1 (en) | 1996-05-17 | 1997-05-16 | Solution and process for resuscitation and reparation of ischemically damaged tissue |
Country Status (12)
Country | Link |
---|---|
US (1) | US5843024A (en) |
EP (1) | EP1021084B2 (en) |
JP (1) | JP4259614B2 (en) |
CN (1) | CN1163125C (en) |
AT (1) | ATE374526T1 (en) |
AU (1) | AU723424B2 (en) |
CA (1) | CA2255657C (en) |
DE (1) | DE69738184T2 (en) |
ES (1) | ES2296310T5 (en) |
HK (1) | HK1021925A1 (en) |
RU (1) | RU2199310C2 (en) |
WO (1) | WO1997043899A1 (en) |
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WO2000018226A2 (en) * | 1998-09-29 | 2000-04-06 | Organ Recovery Systems, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
WO2000019817A1 (en) * | 1998-10-07 | 2000-04-13 | Cedars-Sinai Medical Center | Cell preconditioning and cryopreservation medium |
EP1252293A1 (en) | 2000-01-19 | 2002-10-30 | University Of North Carolina At Chapel Hill | Liver tissue source |
US20050203053A1 (en) * | 1999-07-30 | 2005-09-15 | Wurtman Richard J. | Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function |
US6977140B1 (en) * | 1998-09-29 | 2005-12-20 | Organ Recovery Systems, Inc. | Method for maintaining and/or restoring viability of organs |
US6989376B2 (en) * | 1998-07-31 | 2006-01-24 | Massachusetts Institute Of Technology | Methods for increasing blood cytidine and/or uridine levels and treating cytidine-dependent human diseases |
US20060241077A1 (en) * | 1998-07-31 | 2006-10-26 | Richard Wurtman | Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same |
EP2020247A3 (en) * | 2007-07-31 | 2009-06-03 | Novalung GmbH | Conditioning a patient's blood with gases |
US8143234B2 (en) | 1998-07-31 | 2012-03-27 | Massachusetts Institute Of Technology | Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function |
US8314064B2 (en) * | 1998-07-31 | 2012-11-20 | Massachusetts Institute Of Technology | Uridine administration stimulates membrane production |
US8551452B2 (en) | 2007-11-02 | 2013-10-08 | Massachusetts Institute Of Technology | Uridine dietary supplementation compliance methods and use thereof |
US8785116B2 (en) | 2012-08-10 | 2014-07-22 | Paragonix Technologies, Inc. | Methods for evaluating the suitability of an organ for transplant |
US8796017B2 (en) | 2003-05-21 | 2014-08-05 | Jms Co., Ltd. | Container for preparing serum and regenerative medical process using the same |
US8809303B2 (en) | 2008-04-09 | 2014-08-19 | The University Of North Carolina At Chapel Hill | Methods of regulating actin cytoskeletal rearrangement and intercellular gap formation |
US8828710B2 (en) | 2011-03-15 | 2014-09-09 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
US8835158B2 (en) | 2011-03-15 | 2014-09-16 | Paragonix Technologics, Inc. | Apparatus for oxygenation and perfusion of tissue for organ preservation |
US9253976B2 (en) | 2011-03-15 | 2016-02-09 | Paragonix Technologies, Inc. | Methods and devices for preserving tissues |
US9426979B2 (en) | 2011-03-15 | 2016-08-30 | Paragonix Technologies, Inc. | Apparatus for oxygenation and perfusion of tissue for organ preservation |
CN105918308A (en) * | 2016-04-28 | 2016-09-07 | 上海市胸科医院 | Lung perfusion fluid for perfusing transplant donor lung and preparation method for lung perfusion fluid |
US9457165B2 (en) | 2006-01-24 | 2016-10-04 | Zoll Medical Corporation | Reperfusion protection in resuscitation |
WO2016207337A1 (en) * | 2015-06-25 | 2016-12-29 | Xvivo Perfusion Ab | Isolated organ evaluation and treatment |
US9560846B2 (en) | 2012-08-10 | 2017-02-07 | Paragonix Technologies, Inc. | System for hypothermic transport of biological samples |
US9867368B2 (en) | 2011-03-15 | 2018-01-16 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
US9877474B2 (en) | 2012-09-08 | 2018-01-30 | Organ Technologies, Inc. | Method for maintaining organ or tissue for transplantation use for long period |
US10071218B2 (en) | 2006-01-24 | 2018-09-11 | Zoll Medical Corporation | Reperfusion protection in resuscitation |
US10086139B2 (en) | 2009-10-12 | 2018-10-02 | Resuscitec Gmbh | Device for treating an individual suffering from cardiac insufficiency, cardiac arrest, circulatory arrest or stroke |
US11166452B2 (en) | 2017-06-07 | 2021-11-09 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
US11178866B2 (en) | 2011-03-15 | 2021-11-23 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
US11632951B2 (en) | 2020-01-31 | 2023-04-25 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
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US20060003447A1 (en) * | 2003-12-30 | 2006-01-05 | Richard Fike | Dry powder cells and cell culture reagents and methods of production thereof |
US8409846B2 (en) | 1997-09-23 | 2013-04-02 | The United States Of America As Represented By The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
US6736790B2 (en) | 1998-02-25 | 2004-05-18 | Denise R. Barbut | Method and system for selective or isolated integrate cerebral perfusion and cooling |
US6673594B1 (en) | 1998-09-29 | 2004-01-06 | Organ Recovery Systems | Apparatus and method for maintaining and/or restoring viability of organs |
US7749693B2 (en) | 1998-09-29 | 2010-07-06 | Lifeline Scientific, Inc. | Method of determining that an organ is not suitable for transplantation and using it for testing substances |
US20040038192A1 (en) * | 1999-04-14 | 2004-02-26 | Breonics, Inc. | System for exsanguinous metabolic support of an organ or tissue |
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US20070166292A1 (en) * | 1999-04-14 | 2007-07-19 | Breonics, Inc. | System for exsanguinous metabolic support of an organ or tissue |
US6846842B2 (en) * | 1999-10-07 | 2005-01-25 | Beth Israel Deconess Medical Center, Inc. | Pyruvate ester composition and method of use for resuscitation after events of ischemia and reperfusion |
US6492103B1 (en) * | 2000-01-31 | 2002-12-10 | Organ Recovery Systems, Inc. | System for organ and tissue preservation and hypothermic blood substitution |
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US8465970B2 (en) | 2004-10-07 | 2013-06-18 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
US8304181B2 (en) | 2004-10-07 | 2012-11-06 | Transmedics, Inc. | Method for ex-vivo organ care and for using lactate as an indication of donor organ status |
US9301519B2 (en) | 2004-10-07 | 2016-04-05 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
US20060079479A1 (en) * | 2004-10-13 | 2006-04-13 | Italo Biaggioni | Methods of inducing vasodilation |
US8637230B2 (en) * | 2004-11-12 | 2014-01-28 | Organoflush B.V. | Composition for cold preservation and perfusion of organs |
US20060160062A1 (en) * | 2005-01-14 | 2006-07-20 | Young Lindon H | Perfusion and/or preservation solution for organs |
US20060204482A1 (en) * | 2005-03-14 | 2006-09-14 | Deolden James | Methods of islet isolation and transplantation |
US9078428B2 (en) | 2005-06-28 | 2015-07-14 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
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US10420337B2 (en) | 2013-03-15 | 2019-09-24 | Lifeline Scientific, Inc. | Transporter with a glucose sensor for determining viability of an organ or tissue |
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US9994811B2 (en) | 2014-10-09 | 2018-06-12 | Lauren Brasile | Reducing the immunogenicity of allografts |
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US5370989A (en) * | 1992-04-03 | 1994-12-06 | The Trustees Of Columbia University In The City Of New York | Solution for prolonged organ preservation |
US5362622A (en) * | 1993-03-11 | 1994-11-08 | Board Of Regents, The University Of Texas System | Combined perfusion and oxygenation apparatus |
WO1994021116A1 (en) * | 1993-03-16 | 1994-09-29 | Alliance Pharmaceutical Corp. | Preservation solution and method for warm organ preservation |
US5405742A (en) * | 1993-07-16 | 1995-04-11 | Cyromedical Sciences, Inc. | Solutions for tissue preservation and bloodless surgery and methods using same |
-
1996
- 1996-05-17 US US08/649,200 patent/US5843024A/en not_active Expired - Lifetime
-
1997
- 1997-05-16 DE DE69738184T patent/DE69738184T2/en not_active Expired - Fee Related
- 1997-05-16 CA CA002255657A patent/CA2255657C/en not_active Expired - Lifetime
- 1997-05-16 AT AT97925571T patent/ATE374526T1/en not_active IP Right Cessation
- 1997-05-16 EP EP97925571.8A patent/EP1021084B2/en not_active Expired - Lifetime
- 1997-05-16 JP JP54252797A patent/JP4259614B2/en not_active Expired - Fee Related
- 1997-05-16 WO PCT/US1997/008205 patent/WO1997043899A1/en active IP Right Grant
- 1997-05-16 ES ES97925571.8T patent/ES2296310T5/en not_active Expired - Lifetime
- 1997-05-16 RU RU99102851/14A patent/RU2199310C2/en not_active IP Right Cessation
- 1997-05-16 CN CNB971957681A patent/CN1163125C/en not_active Expired - Fee Related
- 1997-05-16 AU AU30671/97A patent/AU723424B2/en not_active Ceased
-
2000
- 2000-02-18 HK HK00100972A patent/HK1021925A1/en unknown
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Also Published As
Publication number | Publication date |
---|---|
CN1226132A (en) | 1999-08-18 |
HK1021925A1 (en) | 2000-07-21 |
US5843024A (en) | 1998-12-01 |
CN1163125C (en) | 2004-08-25 |
DE69738184D1 (en) | 2007-11-15 |
CA2255657A1 (en) | 1997-11-27 |
DE69738184T2 (en) | 2008-07-24 |
AU3067197A (en) | 1997-12-09 |
EP1021084A4 (en) | 2004-10-13 |
CA2255657C (en) | 2009-09-01 |
AU723424B2 (en) | 2000-08-24 |
ES2296310T3 (en) | 2008-04-16 |
JP2000511531A (en) | 2000-09-05 |
ES2296310T5 (en) | 2016-06-24 |
EP1021084B1 (en) | 2007-10-03 |
JP4259614B2 (en) | 2009-04-30 |
EP1021084B2 (en) | 2016-03-09 |
EP1021084A1 (en) | 2000-07-26 |
EP1021084B9 (en) | 2008-02-27 |
RU2199310C2 (en) | 2003-02-27 |
ATE374526T1 (en) | 2007-10-15 |
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