WO1997043617A3 - Method for dissociating biotin complexes - Google Patents

Method for dissociating biotin complexes Download PDF

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Publication number
WO1997043617A3
WO1997043617A3 PCT/US1997/008052 US9708052W WO9743617A3 WO 1997043617 A3 WO1997043617 A3 WO 1997043617A3 US 9708052 W US9708052 W US 9708052W WO 9743617 A3 WO9743617 A3 WO 9743617A3
Authority
WO
WIPO (PCT)
Prior art keywords
dissociating
biotin complexes
dissociating biotin
complexes
complex
Prior art date
Application number
PCT/US1997/008052
Other languages
French (fr)
Other versions
WO1997043617A2 (en
Inventor
Christian Jurinke
Den Boom Dirk Van
Hubert Koester
Original Assignee
Sequenom Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequenom Inc filed Critical Sequenom Inc
Priority to JP09541041A priority Critical patent/JP2000510702A/en
Priority to CA002253582A priority patent/CA2253582A1/en
Priority to AU31232/97A priority patent/AU714707B2/en
Priority to AT97926469T priority patent/ATE215612T1/en
Priority to DE69711632T priority patent/DE69711632T2/en
Priority to EP97926469A priority patent/EP0914471B1/en
Publication of WO1997043617A2 publication Critical patent/WO1997043617A2/en
Publication of WO1997043617A3 publication Critical patent/WO1997043617A3/en
Priority to HK99102761A priority patent/HK1018967A1/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6823Release of bound markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing

Abstract

A method for dissociating a complex of a biotin compound and a biotin-binding compound, by contacting the complex with an amine, is disclosed.
PCT/US1997/008052 1996-05-13 1997-05-13 Method for dissociating biotin complexes WO1997043617A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP09541041A JP2000510702A (en) 1996-05-13 1997-05-13 Biotin complex dissociation method
CA002253582A CA2253582A1 (en) 1996-05-13 1997-05-13 Method for dissociating biotin complexes
AU31232/97A AU714707B2 (en) 1996-05-13 1997-05-13 Method for dissociating biotin complexes
AT97926469T ATE215612T1 (en) 1996-05-13 1997-05-13 METHOD FOR DISSOCIATION OF BIOTIN COMPLEXES
DE69711632T DE69711632T2 (en) 1996-05-13 1997-05-13 METHOD FOR DISSOCIATING BIOTINE COMPLEXES
EP97926469A EP0914471B1 (en) 1996-05-13 1997-05-13 Method for dissociating biotin complexes
HK99102761A HK1018967A1 (en) 1996-05-13 1999-06-30 Method for dissociating biotin complexes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/649,876 US6022688A (en) 1996-05-13 1996-05-13 Method for dissociating biotin complexes
US08/649,876 1996-05-13

Publications (2)

Publication Number Publication Date
WO1997043617A2 WO1997043617A2 (en) 1997-11-20
WO1997043617A3 true WO1997043617A3 (en) 1998-02-19

Family

ID=24606585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/008052 WO1997043617A2 (en) 1996-05-13 1997-05-13 Method for dissociating biotin complexes

Country Status (9)

Country Link
US (2) US6022688A (en)
EP (1) EP0914471B1 (en)
JP (1) JP2000510702A (en)
AT (1) ATE215612T1 (en)
AU (1) AU714707B2 (en)
CA (1) CA2253582A1 (en)
DE (1) DE69711632T2 (en)
HK (1) HK1018967A1 (en)
WO (1) WO1997043617A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE44693E1 (en) 1996-11-06 2014-01-07 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US8999266B2 (en) 2000-10-30 2015-04-07 Agena Bioscience, Inc. Method and apparatus for delivery of submicroliter volumes onto a substrate
US9034798B2 (en) 2003-01-16 2015-05-19 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US9249456B2 (en) 2004-03-26 2016-02-02 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436635B1 (en) * 1992-11-06 2002-08-20 Boston University Solid phase sequencing of double-stranded nucleic acids
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US6194144B1 (en) 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
US5547835A (en) 1993-01-07 1996-08-20 Sequenom, Inc. DNA sequencing by mass spectrometry
US20060063193A1 (en) * 1995-04-11 2006-03-23 Dong-Jing Fu Solid phase sequencing of double-stranded nucleic acids
US7803529B1 (en) * 1995-04-11 2010-09-28 Sequenom, Inc. Solid phase sequencing of biopolymers
US6146854A (en) * 1995-08-31 2000-11-14 Sequenom, Inc. Filtration processes, kits and devices for isolating plasmids
EP0886681A1 (en) * 1996-03-04 1998-12-30 Genetrace Systems, Inc. Methods of screening nucleic acids using mass spectrometry
US6022688A (en) * 1996-05-13 2000-02-08 Sequenom, Inc. Method for dissociating biotin complexes
US5777324A (en) 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
US5965363A (en) * 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
DE19782095T1 (en) * 1996-11-06 2000-03-23 Sequenom Inc DNA diagnosis based on mass spectrometry
US7285422B1 (en) * 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
DE69735445T2 (en) * 1996-12-10 2006-08-10 Sequenom, Inc., San Diego NON-VOLATILE, NON-VOLATILE MOLECULES FOR MASS MARKING
US6323351B1 (en) 1997-06-30 2001-11-27 The Dow Chemical Company Process for the direct oxidation of olefins to olefin oxides
US6207370B1 (en) 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US6225061B1 (en) 1999-03-10 2001-05-01 Sequenom, Inc. Systems and methods for performing reactions in an unsealed environment
US20010049438A1 (en) * 1999-03-19 2001-12-06 Dix Connie Kim Purification of primer extension products
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US7332275B2 (en) * 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
US20030207297A1 (en) * 1999-10-13 2003-11-06 Hubert Koster Methods for generating databases and databases for identifying polymorphic genetic markers
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
JP2001245698A (en) * 1999-11-22 2001-09-11 Xiao Bing Wang Method for detecting nucleic acid
US6660229B2 (en) 2000-06-13 2003-12-09 The Trustees Of Boston University Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing
GB0102568D0 (en) * 2001-02-01 2001-03-21 Magnetic Biosolutions Sweden A Method
US20030036057A1 (en) * 2001-03-09 2003-02-20 Andreas Braun Genes and polymorphisms associated with cardiovascular disease and their use
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
EP2053406A3 (en) * 2001-07-16 2009-06-24 caprotec bioanalytics GmbH Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
CA2464682A1 (en) * 2001-10-26 2003-05-01 Sequenom, Inc. Method and apparatus for high-throughput sample handling process line
US20030157575A1 (en) * 2002-01-28 2003-08-21 Shane Climie Chemical proteomics
US20030166007A1 (en) * 2002-01-28 2003-09-04 Mds Proteomics Inc. Chemical proteomics
AU2003215083A1 (en) * 2002-02-06 2003-09-02 Tethys Bioscience, Inc. Method and apparatus for validating dna sequences without sequencing
KR20020041344A (en) * 2002-02-26 2002-06-01 김희태 A method for detecting a amplified nucleic acid using a membrane chromatograph
US20040209255A1 (en) * 2002-03-11 2004-10-21 Hk Pharmaceuticals, Inc. Compounds and methods for analyzing the proteome
US7432342B2 (en) * 2002-05-03 2008-10-07 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof and related documents
EP1552025A4 (en) * 2002-10-18 2006-12-13 Cylene Pharmaceuticals Inc Processes for identifying quadruplex-targeted antiviral molecules
CA2507189C (en) * 2002-11-27 2018-06-12 Sequenom, Inc. Fragmentation-based methods and systems for sequence variation detection and discovery
ES2342665T3 (en) * 2003-01-29 2010-07-12 454 Corporation SEQUENCING FROM TWO EXTREME.
US20070141570A1 (en) * 2003-03-07 2007-06-21 Sequenom, Inc. Association of polymorphic kinase anchor proteins with cardiac phenotypes and related methods
AU2004235331B2 (en) * 2003-04-25 2008-12-18 Sequenom, Inc. Fragmentation-based methods and systems for De Novo sequencing
JP5183063B2 (en) 2003-07-05 2013-04-17 ザ ジョンズ ホプキンス ユニバーシティ Methods and compositions for detection and enumeration of genetic variations
US8003317B2 (en) 2003-07-31 2011-08-23 Sequenom, Inc. Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions
US20050095627A1 (en) * 2003-09-03 2005-05-05 The Salk Institute For Biological Studies Multiple antigen detection assays and reagents
CA2553833C (en) * 2004-01-28 2012-10-02 454 Corporation Nucleic acid amplification with continuous flow emulsion
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
WO2006031745A2 (en) * 2004-09-10 2006-03-23 Sequenom, Inc. Methods for long-range sequence analysis of nucleic acids
WO2007056113A2 (en) * 2005-11-02 2007-05-18 Cylene Pharmaceuticals, Inc. Methods for targeting quadruplex sequences
EP2035439A4 (en) 2006-06-05 2010-01-13 Cancer Care Ontario Assessment of risk for colorectal cancer
AU2008222563A1 (en) 2007-03-05 2008-09-12 Cancer Care Ontario Assessment of risk for colorectal cancer
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
US20090180931A1 (en) 2007-09-17 2009-07-16 Sequenom, Inc. Integrated robotic sample transfer device
JP2011502162A (en) * 2007-10-29 2011-01-20 ザ ユニバーシティー オブ カリフォルニア Osteoarthritis gene therapy
WO2010012002A1 (en) * 2008-07-25 2010-01-28 Saryna Medical Corporation Methods and systems for genetic analysis of fetal nucleated red blood cells
US8940501B2 (en) 2009-01-30 2015-01-27 Whitehead Institute For Biomedical Research Methods for ligation and uses thereof
JP5686098B2 (en) * 2009-09-17 2015-03-18 Jsr株式会社 Dissociation method and dissociator for avidin and biotin derivative
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
US9139874B2 (en) 2011-07-07 2015-09-22 Life Technologies Corporation Bi-directional sequencing compositions and methods
WO2016120247A1 (en) * 2015-01-26 2016-08-04 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Methods for a quantitative release of biotinylated peptides and proteins from streptavidin complexes
WO2017050874A1 (en) 2015-09-25 2017-03-30 F. Hoffmann-La Roche Ag Process for producing thioesters employing a sortase a
WO2017050866A1 (en) 2015-09-25 2017-03-30 F. Hoffmann-La Roche Ag Novel soluble sortase a
CN108026560A (en) 2015-09-25 2018-05-11 豪夫迈·罗氏有限公司 Reacted in eutectic solvent using the acid amides that turns of sorting enzyme
MA45489A (en) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh CELL CULTURE PROCESSES, ASSOCIATED KITS AND APPARATUS
EP3436578B1 (en) 2016-03-30 2022-01-19 F. Hoffmann-La Roche AG Improved sortase
NZ758485A (en) 2017-04-27 2024-02-23 Juno Therapeutics Gmbh Oligomeric particle reagents and methods of use thereof
EP3969611A1 (en) * 2020-02-03 2022-03-23 Illumina, Inc. Biotin-streptavidin cleavage composition and library fragment cleavage

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0456304A1 (en) * 1990-05-04 1991-11-13 Johnson & Johnson Clinical Diagnostics, Inc. Preparation and isolation of single-stranded biotinylated nucleic acids by avidin-biotin cleavage
WO1994016101A2 (en) * 1993-01-07 1994-07-21 Koester Hubert Dna sequencing by mass spectrometry
EP0701001A2 (en) * 1994-09-07 1996-03-13 Hitachi, Ltd. DNA separating, fractionating and analyzing method and system therefor

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283342A (en) * 1992-06-09 1994-02-01 Neorx Corporation Biotinylated small molecules
US4282287A (en) 1980-01-24 1981-08-04 Giese Roger W Biochemical avidin-biotin multiple-layer system
DE3476218D1 (en) * 1983-02-24 1989-02-23 Ciba Geigy Ag Reactive dyes, their preparation and their use
US4762881A (en) 1987-01-09 1988-08-09 E. I. Du Pont De Nemours And Company Photoreactive benzoylphenylalanines and related peptides
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
WO1991011533A1 (en) * 1990-01-26 1991-08-08 E.I. Du Pont De Nemours And Company Method for isolating primer extension products from template-directed dna polymerase reactions
US5292444A (en) * 1992-10-02 1994-03-08 Exxon Research And Engineering Company Lube oil compositions containing fullerene-grafted polymers
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5527675A (en) * 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
US5643722A (en) 1994-05-11 1997-07-01 Trustees Of Boston University Methods for the detection and isolation of proteins
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5605708A (en) 1995-09-11 1997-02-25 Cummins Eagle, Inc. Rounder apparatus for processing bakery dough
US5928906A (en) 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
US6022688A (en) * 1996-05-13 2000-02-08 Sequenom, Inc. Method for dissociating biotin complexes
DK0937096T3 (en) 1996-11-06 2004-06-14 Sequenom Inc Method of mass spectrometry analysis
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
CA2267070A1 (en) 1996-11-06 1998-05-14 Sequenom, Inc. Compositions and methods for immobilizing nucleic acids to solid supports
DE19782095T1 (en) 1996-11-06 2000-03-23 Sequenom Inc DNA diagnosis based on mass spectrometry
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0456304A1 (en) * 1990-05-04 1991-11-13 Johnson & Johnson Clinical Diagnostics, Inc. Preparation and isolation of single-stranded biotinylated nucleic acids by avidin-biotin cleavage
WO1994016101A2 (en) * 1993-01-07 1994-07-21 Koester Hubert Dna sequencing by mass spectrometry
EP0701001A2 (en) * 1994-09-07 1996-03-13 Hitachi, Ltd. DNA separating, fractionating and analyzing method and system therefor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GREEN: "Avidin", ADVANCES IN PROTEIN CHEMISTRY, vol. 29, 1975, pages 85 - 133, XP002050152 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE44693E1 (en) 1996-11-06 2014-01-07 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US8999266B2 (en) 2000-10-30 2015-04-07 Agena Bioscience, Inc. Method and apparatus for delivery of submicroliter volumes onto a substrate
US9034798B2 (en) 2003-01-16 2015-05-19 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
US9249456B2 (en) 2004-03-26 2016-02-02 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis

Also Published As

Publication number Publication date
AU714707B2 (en) 2000-01-06
US6303309B1 (en) 2001-10-16
AU3123297A (en) 1997-12-05
DE69711632D1 (en) 2002-05-08
US6022688A (en) 2000-02-08
HK1018967A1 (en) 2000-01-14
EP0914471A2 (en) 1999-05-12
ATE215612T1 (en) 2002-04-15
JP2000510702A (en) 2000-08-22
EP0914471B1 (en) 2002-04-03
WO1997043617A2 (en) 1997-11-20
DE69711632T2 (en) 2002-10-24
CA2253582A1 (en) 1997-11-20

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