WO1997039963A1 - Blister pack with security strip - Google Patents

Blister pack with security strip Download PDF

Info

Publication number
WO1997039963A1
WO1997039963A1 PCT/GB1997/001108 GB9701108W WO9739963A1 WO 1997039963 A1 WO1997039963 A1 WO 1997039963A1 GB 9701108 W GB9701108 W GB 9701108W WO 9739963 A1 WO9739963 A1 WO 9739963A1
Authority
WO
WIPO (PCT)
Prior art keywords
blister
blister pack
strip
pack according
sheet
Prior art date
Application number
PCT/GB1997/001108
Other languages
French (fr)
Inventor
James Lake Robertson
Original Assignee
James Lake Robertson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by James Lake Robertson filed Critical James Lake Robertson
Priority to AU23957/97A priority Critical patent/AU2395797A/en
Publication of WO1997039963A1 publication Critical patent/WO1997039963A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2215/00—Child-proof means
    • B65D2215/04—Child-proof means requiring the combination of different actions in succession
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2575/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D2575/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by association or interconnecting two or more sheets or blanks
    • B65D2575/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D2575/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D2575/3209—Details
    • B65D2575/3218—Details with special means for gaining access to the contents
    • B65D2575/3245—Details with special means for gaining access to the contents by peeling off the non-rigid sheet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2585/00—Containers, packaging elements or packages specially adapted for particular articles or materials
    • B65D2585/56—Containers, packaging elements or packages specially adapted for particular articles or materials for medicinal tablets or pills

Definitions

  • This invention relates to a blister pack and particularly to a blister pack for solid medicaments and the 1 ike.
  • Blister packs are frequently used for pharmaceutical tablets. They usually comprise a relatively rigid plastics sheet having recesses (or blisters) therein and a cover sheet of frangible foil/plastics laminate. Tablets are placed one in each blister during manufacture and the laminate is heat sealed to the blister sheet to close the blisters in a hermetic and sterile manner. Tablets are dispensed by depressing the blister, thus causing the tablet to burst through the foil laminate.
  • the blister sheet is usually of clear plastic and thus a blister pack is tamper evident. For this reason, and partly due to legislation, the dispensing of tablets in blister packs is increasing. Furthermore the laminate may be printed with information concerning the order and day on which tablets are to be taken; this is especially useful in the case of oral contraceptives.
  • Blister packs are not child resistant because the force necessary to break the foil laminate is low. It is undesirable to increase laminate strength since this may give difficulty to the elderly.
  • One solution is to supply blister packs in a separate container with a child resistant cap (CRC) but this increases cost whilst relying on the vigilance of the patient. What is required is an inexpensive method of rendering blister packs inherently child resistant.
  • a blister pack comprising a blister sheet and a cover sheet fixed thereto to define a plurality of individual blisters, an unburstable security strip extending over a plurality of individual blisters and being adapted to permit individual blisters to be opened in predetermined sequence.
  • the strip lies against the cover sheet and extends over the individual blisters to prevent the contents of the blisters being burst through the cover sheet, means being provided to release the strip according to instructions printed on the pack.
  • the strip extends both above and below the chambers defined by the individual blisters and may comprise upper and lower thread portions joined by a slip knot between each blister of a sequence, the ends of the thread portions being secured in a manner which permits one blister to be opened.
  • This arrangement has the advantage that printed instructions can identify the only blister which is capable of being opened, correct opening of the first blister and consequent slacking of the thread portions permitting the second blister of the sequence to be opened, and so on.
  • the security strip comprises a single strip overlying each blister chamber and attached or sealed to the blister sheet, for example by heat, on each side of each chamber in a manner which permits opening of blisters in sequence.
  • the strip may be secured by directional release means in such a way as to ensure weakening of the next sequential attachment as the contents of the preceding blister is ejected.
  • a peelable seal may be suitable. This arrangement again relies on identification of the first blister by for example printing on the blister pack.
  • the blisters may be arranged to open in a straight line sequence or in a random sequence.
  • the present invention also ensures that patients take blister packed medicaments in a predetermined sequence rather than randomly from the blister pack. This is especially useful in the case of tablets having different dose requirements over time, or placebo doses.
  • oral contraceptives often comprise a 21 day sequence followed by 7 dose free days.
  • Some patients prefer a 28 day pack containing 7 placebos but in this case it is absolutely essential that the tablets are taken in the correct sequence.
  • the present invention ensures that the correct sequence can be followed, which is not the case where medicaments are supplied in separate containers.
  • Fig. 1 illustrates a portion of a blister pack from above
  • Fig. 2 illustrates a portion of a blister pack from be1ow
  • Fig. 3 is a somewhat schematic side elevation of a blister pack.
  • a blister pack comprises the usual clear plastics blister sheet 11 having a plurality of individual part spherical blisters 12.
  • a cover sheet 13 comprising a foil/plastics laminate is heat sealed to the blister sheet around each blister 12 to define individual hermetically sealed chambers 14 each containing a tablet 15 (one illustrated).
  • the blister pack according to the invention includes a double thread 17 extending above and below each tablet of each blister and joined between adjacent blisters by a series of slip knots 18. Individual tablets are surrounded by the double thread 17 during the manufacturing process, and the thread is sufficiently strong to ensure that it cannot be burst by the application of normal pressure on the blisters; the tablets are thus secured against release in the normal manner.
  • the threads are hidden from view by the cover sheet, and if observed through the blister sheet they look alike.
  • One tablet in the sequence is however arranged with loose threads, for example that associated with end chamber 14A, and identified by writing or printing on the blister pack itself. Accordingly the patient can remove the first tablet of a sequence, and once removed the slack thread 17 permits the next tablet of the sequence to be ejected, and so on. In practice the double thread slides through the slip knot from the opened blister as the next tablet is ejected and this permits the next tablet to be released whilst leaving the remaining tablets of the sequence undisturbed and secure.
  • the type of thread or security strip, the materials and the manner in which it is secured between the blister sheet and the cover sheet can be selected according to the size of blister, required ejection force and the like.
  • the present invention also discloses an unburstable security strip between the blister sheet and the cover sheet.
  • a security strip could lie on the outside of the cover sheet and be adapted to permit opening of blisters in a predetermined sequence, for example by directionally sensitive heat sealing as previously described.
  • 'strip' includes any flexible longitudinal member adapted to prevent bursting of a blister, and includes strings, cords, threads and the 1ike.

Abstract

A blister pack includes an unburstable security strip (17) which ensures that individual blisters are opened in a predetermined sequence. Printed indicia are included to indicate the manner in which the first blister of the sequence can be opened. The pack is suitable for pharmaceutical tablets and provides resistance to unauthorized opening by children.

Description

BLISTER PACK WITH SECURITY STRIP
This invention relates to a blister pack and particularly to a blister pack for solid medicaments and the 1 ike. Blister packs are frequently used for pharmaceutical tablets. They usually comprise a relatively rigid plastics sheet having recesses (or blisters) therein and a cover sheet of frangible foil/plastics laminate. Tablets are placed one in each blister during manufacture and the laminate is heat sealed to the blister sheet to close the blisters in a hermetic and sterile manner. Tablets are dispensed by depressing the blister, thus causing the tablet to burst through the foil laminate.
The blister sheet is usually of clear plastic and thus a blister pack is tamper evident. For this reason, and partly due to legislation, the dispensing of tablets in blister packs is increasing. Furthermore the laminate may be printed with information concerning the order and day on which tablets are to be taken; this is especially useful in the case of oral contraceptives.
Blister packs are not child resistant because the force necessary to break the foil laminate is low. It is undesirable to increase laminate strength since this may give difficulty to the elderly. One solution is to supply blister packs in a separate container with a child resistant cap (CRC) but this increases cost whilst relying on the vigilance of the patient. What is required is an inexpensive method of rendering blister packs inherently child resistant.
According to the present invention there is provided a blister pack comprising a blister sheet and a cover sheet fixed thereto to define a plurality of individual blisters, an unburstable security strip extending over a plurality of individual blisters and being adapted to permit individual blisters to be opened in predetermined sequence.
In a preferred embodiment the strip lies against the cover sheet and extends over the individual blisters to prevent the contents of the blisters being burst through the cover sheet, means being provided to release the strip according to instructions printed on the pack.
In this way a child who cannot read iε unable to determine the manner in which the security strip is released. In a preferred embodiment the strip extends both above and below the chambers defined by the individual blisters and may comprise upper and lower thread portions joined by a slip knot between each blister of a sequence, the ends of the thread portions being secured in a manner which permits one blister to be opened. This arrangement has the advantage that printed instructions can identify the only blister which is capable of being opened, correct opening of the first blister and consequent slacking of the thread portions permitting the second blister of the sequence to be opened, and so on.
In an alternative embodiment the security strip comprises a single strip overlying each blister chamber and attached or sealed to the blister sheet, for example by heat, on each side of each chamber in a manner which permits opening of blisters in sequence. For example the strip may be secured by directional release means in such a way as to ensure weakening of the next sequential attachment as the contents of the preceding blister is ejected. A peelable seal may be suitable. This arrangement again relies on identification of the first blister by for example printing on the blister pack.
The blisters may be arranged to open in a straight line sequence or in a random sequence.
The present invention also ensures that patients take blister packed medicaments in a predetermined sequence rather than randomly from the blister pack. This is especially useful in the case of tablets having different dose requirements over time, or placebo doses. For example oral contraceptives often comprise a 21 day sequence followed by 7 dose free days. Some patients prefer a 28 day pack containing 7 placebos but in this case it is absolutely essential that the tablets are taken in the correct sequence. The same applies in the case of different medicaments which must be taken in a predetermined sequence to have a desired effect. The present invention ensures that the correct sequence can be followed, which is not the case where medicaments are supplied in separate containers.
An embodiment of the invention will now be described with reference to a preferred embodiment shown by way of example only in the accompanying drawings in which:
Fig. 1 illustrates a portion of a blister pack from above;
Fig. 2 illustrates a portion of a blister pack from be1ow; and
Fig. 3 is a somewhat schematic side elevation of a blister pack.
With reference to the drawings, a blister pack comprises the usual clear plastics blister sheet 11 having a plurality of individual part spherical blisters 12. A cover sheet 13 comprising a foil/plastics laminate is heat sealed to the blister sheet around each blister 12 to define individual hermetically sealed chambers 14 each containing a tablet 15 (one illustrated).
The foregoing describes a conventional blister pack from which tablets are individually extracted by depressing a blister in the direction of arrow 16 and bursting the tablet through the cover sheet 13 immediately over the blister.
The blister pack according to the invention includes a double thread 17 extending above and below each tablet of each blister and joined between adjacent blisters by a series of slip knots 18. Individual tablets are surrounded by the double thread 17 during the manufacturing process, and the thread is sufficiently strong to ensure that it cannot be burst by the application of normal pressure on the blisters; the tablets are thus secured against release in the normal manner. The threads are hidden from view by the cover sheet, and if observed through the blister sheet they look alike.
One tablet in the sequence is however arranged with loose threads, for example that associated with end chamber 14A, and identified by writing or printing on the blister pack itself. Accordingly the patient can remove the first tablet of a sequence, and once removed the slack thread 17 permits the next tablet of the sequence to be ejected, and so on. In practice the double thread slides through the slip knot from the opened blister as the next tablet is ejected and this permits the next tablet to be released whilst leaving the remaining tablets of the sequence undisturbed and secure. The type of thread or security strip, the materials and the manner in which it is secured between the blister sheet and the cover sheet can be selected according to the size of blister, required ejection force and the like.
Although the invention has been described in relation to pharmaceutical tablets, it is also applicable to blister packing in which a particular sequence of opening is desirable, for example in model making or in the use of reactive chemicals.
The present invention also discloses an unburstable security strip between the blister sheet and the cover sheet. In the alternative however such a security strip could lie on the outside of the cover sheet and be adapted to permit opening of blisters in a predetermined sequence, for example by directionally sensitive heat sealing as previously described.
In this specification the term 'strip' includes any flexible longitudinal member adapted to prevent bursting of a blister, and includes strings, cords, threads and the 1ike.

Claims

CLAIMS:
1. A blister pack comprising a blister sheet and a cover sheet fixed thereto to define a plurality of individual blisters, an unburstable security strip extending over a plurality of individual blisters and being adapted to permit individual blisters to be opened in a predetermined sequence.
2. A blister pack according to claim 1 wherein said strip lies against said cover sheet.
3. A blister pack according to claim 1 or claim 2 wherein said strip lies between said blister sheet and said cover sheet.
4. A blister pack according to any preceding claim wherein said strip is attached to said blister pack.
5. A blister pack according to claim 4 wherein said strip is heat sealed to said blister pack.
6. A blister pack according to any preceding claim wherein said strip extends both above and below chambers defined by individual blisters of said blister sheet.
7. A blister pack according to any preceding claims wherein said strip is secured by directional release means.
8. A blister pack according to claim 7 wherein said strip comprises an upper thread portion and a lower thread portion, the thread portions being joined between each blister of a sequence.
9. A blister pack according to claim 7 wherein the thread portions are joined between each blister by a slip knot, the ends of the thread portions being secured in a manner which permits one preselected blister to be first opened, and the slip knots permitting slackening of the thread portions in said predetermined sequence.
10. A blister pack according to claim 7 wherein said directional release means comprises a peelable seal releasable by peeling in predetermined direction.
11. A blister pack according to any preceding claim and further including printed indicia to indicate the first blister of said predetermined sequence.
PCT/GB1997/001108 1996-04-22 1997-04-22 Blister pack with security strip WO1997039963A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU23957/97A AU2395797A (en) 1996-04-22 1997-04-22 Blister pack with security strip

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9608268.0A GB9608268D0 (en) 1996-04-22 1996-04-22 Blister pack
GB9608268.0 1996-04-22

Publications (1)

Publication Number Publication Date
WO1997039963A1 true WO1997039963A1 (en) 1997-10-30

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Country Status (3)

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AU (1) AU2395797A (en)
GB (2) GB9608268D0 (en)
WO (1) WO1997039963A1 (en)

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US7000769B2 (en) 2003-05-20 2006-02-21 Smithkline Beecham Corporation Child resistant blister packages utilizing walled structures enclosing medicament therein
WO2013070914A3 (en) * 2011-11-09 2013-08-08 Proteus Digital Health, Inc. Apparatus, system, and method for managing adherence to a regimen
US8836513B2 (en) 2006-04-28 2014-09-16 Proteus Digital Health, Inc. Communication system incorporated in an ingestible product
US8847766B2 (en) 2005-04-28 2014-09-30 Proteus Digital Health, Inc. Pharma-informatics system
US8858432B2 (en) 2007-02-01 2014-10-14 Proteus Digital Health, Inc. Ingestible event marker systems
US8868453B2 (en) 2009-11-04 2014-10-21 Proteus Digital Health, Inc. System for supply chain management
US8912908B2 (en) 2005-04-28 2014-12-16 Proteus Digital Health, Inc. Communication system with remote activation
US8932221B2 (en) 2007-03-09 2015-01-13 Proteus Digital Health, Inc. In-body device having a multi-directional transmitter
US8945005B2 (en) 2006-10-25 2015-02-03 Proteus Digital Health, Inc. Controlled activation ingestible identifier
US8956288B2 (en) 2007-02-14 2015-02-17 Proteus Digital Health, Inc. In-body power source having high surface area electrode
US8956287B2 (en) 2006-05-02 2015-02-17 Proteus Digital Health, Inc. Patient customized therapeutic regimens
US8961412B2 (en) 2007-09-25 2015-02-24 Proteus Digital Health, Inc. In-body device with virtual dipole signal amplification
US9060708B2 (en) 2008-03-05 2015-06-23 Proteus Digital Health, Inc. Multi-mode communication ingestible event markers and systems, and methods of using the same
US9083589B2 (en) 2006-11-20 2015-07-14 Proteus Digital Health, Inc. Active signal processing personal health signal receivers
US9107806B2 (en) 2010-11-22 2015-08-18 Proteus Digital Health, Inc. Ingestible device with pharmaceutical product
US9119918B2 (en) 2009-03-25 2015-09-01 Proteus Digital Health, Inc. Probablistic pharmacokinetic and pharmacodynamic modeling
US9149423B2 (en) 2009-05-12 2015-10-06 Proteus Digital Health, Inc. Ingestible event markers comprising an ingestible component
US9198608B2 (en) 2005-04-28 2015-12-01 Proteus Digital Health, Inc. Communication system incorporated in a container
US9270025B2 (en) 2007-03-09 2016-02-23 Proteus Digital Health, Inc. In-body device having deployable antenna
US9271897B2 (en) 2012-07-23 2016-03-01 Proteus Digital Health, Inc. Techniques for manufacturing ingestible event markers comprising an ingestible component
US9320455B2 (en) 2009-04-28 2016-04-26 Proteus Digital Health, Inc. Highly reliable ingestible event markers and methods for using the same
US9415010B2 (en) 2008-08-13 2016-08-16 Proteus Digital Health, Inc. Ingestible circuitry
US9597487B2 (en) 2010-04-07 2017-03-21 Proteus Digital Health, Inc. Miniature ingestible device
US9603550B2 (en) 2008-07-08 2017-03-28 Proteus Digital Health, Inc. State characterization based on multi-variate data fusion techniques
US9756874B2 (en) 2011-07-11 2017-09-12 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
US9883819B2 (en) 2009-01-06 2018-02-06 Proteus Digital Health, Inc. Ingestion-related biofeedback and personalized medical therapy method and system
US9962107B2 (en) 2005-04-28 2018-05-08 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
US10175376B2 (en) 2013-03-15 2019-01-08 Proteus Digital Health, Inc. Metal detector apparatus, system, and method
US10187121B2 (en) 2016-07-22 2019-01-22 Proteus Digital Health, Inc. Electromagnetic sensing and detection of ingestible event markers
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US10398161B2 (en) 2014-01-21 2019-09-03 Proteus Digital Heal Th, Inc. Masticable ingestible product and communication system therefor
US10517506B2 (en) 2007-05-24 2019-12-31 Proteus Digital Health, Inc. Low profile antenna for in body device
US10529044B2 (en) 2010-05-19 2020-01-07 Proteus Digital Health, Inc. Tracking and delivery confirmation of pharmaceutical products
US11051543B2 (en) 2015-07-21 2021-07-06 Otsuka Pharmaceutical Co. Ltd. Alginate on adhesive bilayer laminate film
US11149123B2 (en) 2013-01-29 2021-10-19 Otsuka Pharmaceutical Co., Ltd. Highly-swellable polymeric films and compositions comprising the same
US11529071B2 (en) 2016-10-26 2022-12-20 Otsuka Pharmaceutical Co., Ltd. Methods for manufacturing capsules with ingestible event markers
US11612321B2 (en) 2007-11-27 2023-03-28 Otsuka Pharmaceutical Co., Ltd. Transbody communication systems employing communication channels
US11744481B2 (en) 2013-03-15 2023-09-05 Otsuka Pharmaceutical Co., Ltd. System, apparatus and methods for data collection and assessing outcomes

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9915643D0 (en) 1999-07-06 1999-09-01 Pago Ltd Blister packs

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR782832A (en) * 1935-07-26 1935-06-12 Ivers Lee Co Improvements to the packaging of certain items
US2546698A (en) * 1943-10-20 1951-03-27 Nicolic Charles Sheet material with weakened tearing line
FR2227190A1 (en) * 1973-04-28 1974-11-22 Alusuisse
US4232787A (en) * 1979-04-02 1980-11-11 Anne Holiday Food packaging
US5469968A (en) * 1994-09-22 1995-11-28 Reynolds Metals Company Peel-peel-push childproof packaging structure
WO1996003329A1 (en) * 1994-07-26 1996-02-08 Pharmacia & Upjohn Company Convertible child-resistant blister package

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB323977A (en) * 1929-03-21 1930-01-16 Gustav Sullwald Improvements in packing cigarettes and the like

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR782832A (en) * 1935-07-26 1935-06-12 Ivers Lee Co Improvements to the packaging of certain items
US2546698A (en) * 1943-10-20 1951-03-27 Nicolic Charles Sheet material with weakened tearing line
FR2227190A1 (en) * 1973-04-28 1974-11-22 Alusuisse
US4232787A (en) * 1979-04-02 1980-11-11 Anne Holiday Food packaging
WO1996003329A1 (en) * 1994-07-26 1996-02-08 Pharmacia & Upjohn Company Convertible child-resistant blister package
US5469968A (en) * 1994-09-22 1995-11-28 Reynolds Metals Company Peel-peel-push childproof packaging structure

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US7000769B2 (en) 2003-05-20 2006-02-21 Smithkline Beecham Corporation Child resistant blister packages utilizing walled structures enclosing medicament therein
US7328802B2 (en) 2003-05-20 2008-02-12 Smithkline Beecham Corporation Child resistant blister packages utilizing walled structures enclosing medicament therein
US10610128B2 (en) 2005-04-28 2020-04-07 Proteus Digital Health, Inc. Pharma-informatics system
US9649066B2 (en) 2005-04-28 2017-05-16 Proteus Digital Health, Inc. Communication system with partial power source
US8847766B2 (en) 2005-04-28 2014-09-30 Proteus Digital Health, Inc. Pharma-informatics system
US10517507B2 (en) 2005-04-28 2019-12-31 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
US10542909B2 (en) 2005-04-28 2020-01-28 Proteus Digital Health, Inc. Communication system with partial power source
US8912908B2 (en) 2005-04-28 2014-12-16 Proteus Digital Health, Inc. Communication system with remote activation
US9681842B2 (en) 2005-04-28 2017-06-20 Proteus Digital Health, Inc. Pharma-informatics system
US9161707B2 (en) 2005-04-28 2015-10-20 Proteus Digital Health, Inc. Communication system incorporated in an ingestible product
US9198608B2 (en) 2005-04-28 2015-12-01 Proteus Digital Health, Inc. Communication system incorporated in a container
US9119554B2 (en) 2005-04-28 2015-09-01 Proteus Digital Health, Inc. Pharma-informatics system
US11476952B2 (en) 2005-04-28 2022-10-18 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
US9439582B2 (en) 2005-04-28 2016-09-13 Proteus Digital Health, Inc. Communication system with remote activation
US9962107B2 (en) 2005-04-28 2018-05-08 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
US8836513B2 (en) 2006-04-28 2014-09-16 Proteus Digital Health, Inc. Communication system incorporated in an ingestible product
US8956287B2 (en) 2006-05-02 2015-02-17 Proteus Digital Health, Inc. Patient customized therapeutic regimens
US11928614B2 (en) 2006-05-02 2024-03-12 Otsuka Pharmaceutical Co., Ltd. Patient customized therapeutic regimens
US10238604B2 (en) 2006-10-25 2019-03-26 Proteus Digital Health, Inc. Controlled activation ingestible identifier
US11357730B2 (en) 2006-10-25 2022-06-14 Otsuka Pharmaceutical Co., Ltd. Controlled activation ingestible identifier
US8945005B2 (en) 2006-10-25 2015-02-03 Proteus Digital Health, Inc. Controlled activation ingestible identifier
US9444503B2 (en) 2006-11-20 2016-09-13 Proteus Digital Health, Inc. Active signal processing personal health signal receivers
US9083589B2 (en) 2006-11-20 2015-07-14 Proteus Digital Health, Inc. Active signal processing personal health signal receivers
US10441194B2 (en) 2007-02-01 2019-10-15 Proteus Digital Heal Th, Inc. Ingestible event marker systems
US8858432B2 (en) 2007-02-01 2014-10-14 Proteus Digital Health, Inc. Ingestible event marker systems
US11464423B2 (en) 2007-02-14 2022-10-11 Otsuka Pharmaceutical Co., Ltd. In-body power source having high surface area electrode
US8956288B2 (en) 2007-02-14 2015-02-17 Proteus Digital Health, Inc. In-body power source having high surface area electrode
US9270025B2 (en) 2007-03-09 2016-02-23 Proteus Digital Health, Inc. In-body device having deployable antenna
US8932221B2 (en) 2007-03-09 2015-01-13 Proteus Digital Health, Inc. In-body device having a multi-directional transmitter
US10517506B2 (en) 2007-05-24 2019-12-31 Proteus Digital Health, Inc. Low profile antenna for in body device
US9433371B2 (en) 2007-09-25 2016-09-06 Proteus Digital Health, Inc. In-body device with virtual dipole signal amplification
US8961412B2 (en) 2007-09-25 2015-02-24 Proteus Digital Health, Inc. In-body device with virtual dipole signal amplification
US11612321B2 (en) 2007-11-27 2023-03-28 Otsuka Pharmaceutical Co., Ltd. Transbody communication systems employing communication channels
US9060708B2 (en) 2008-03-05 2015-06-23 Proteus Digital Health, Inc. Multi-mode communication ingestible event markers and systems, and methods of using the same
US9258035B2 (en) 2008-03-05 2016-02-09 Proteus Digital Health, Inc. Multi-mode communication ingestible event markers and systems, and methods of using the same
US9603550B2 (en) 2008-07-08 2017-03-28 Proteus Digital Health, Inc. State characterization based on multi-variate data fusion techniques
US10682071B2 (en) 2008-07-08 2020-06-16 Proteus Digital Health, Inc. State characterization based on multi-variate data fusion techniques
US11217342B2 (en) 2008-07-08 2022-01-04 Otsuka Pharmaceutical Co., Ltd. Ingestible event marker data framework
US9415010B2 (en) 2008-08-13 2016-08-16 Proteus Digital Health, Inc. Ingestible circuitry
US9883819B2 (en) 2009-01-06 2018-02-06 Proteus Digital Health, Inc. Ingestion-related biofeedback and personalized medical therapy method and system
US9119918B2 (en) 2009-03-25 2015-09-01 Proteus Digital Health, Inc. Probablistic pharmacokinetic and pharmacodynamic modeling
US9320455B2 (en) 2009-04-28 2016-04-26 Proteus Digital Health, Inc. Highly reliable ingestible event markers and methods for using the same
US10588544B2 (en) 2009-04-28 2020-03-17 Proteus Digital Health, Inc. Highly reliable ingestible event markers and methods for using the same
US9149423B2 (en) 2009-05-12 2015-10-06 Proteus Digital Health, Inc. Ingestible event markers comprising an ingestible component
US8868453B2 (en) 2009-11-04 2014-10-21 Proteus Digital Health, Inc. System for supply chain management
US10305544B2 (en) 2009-11-04 2019-05-28 Proteus Digital Health, Inc. System for supply chain management
US9941931B2 (en) 2009-11-04 2018-04-10 Proteus Digital Health, Inc. System for supply chain management
US10207093B2 (en) 2010-04-07 2019-02-19 Proteus Digital Health, Inc. Miniature ingestible device
US9597487B2 (en) 2010-04-07 2017-03-21 Proteus Digital Health, Inc. Miniature ingestible device
US11173290B2 (en) 2010-04-07 2021-11-16 Otsuka Pharmaceutical Co., Ltd. Miniature ingestible device
US10529044B2 (en) 2010-05-19 2020-01-07 Proteus Digital Health, Inc. Tracking and delivery confirmation of pharmaceutical products
US9107806B2 (en) 2010-11-22 2015-08-18 Proteus Digital Health, Inc. Ingestible device with pharmaceutical product
US11504511B2 (en) 2010-11-22 2022-11-22 Otsuka Pharmaceutical Co., Ltd. Ingestible device with pharmaceutical product
US9756874B2 (en) 2011-07-11 2017-09-12 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
US11229378B2 (en) 2011-07-11 2022-01-25 Otsuka Pharmaceutical Co., Ltd. Communication system with enhanced partial power source and method of manufacturing same
US10223905B2 (en) 2011-07-21 2019-03-05 Proteus Digital Health, Inc. Mobile device and system for detection and communication of information received from an ingestible device
US9235683B2 (en) 2011-11-09 2016-01-12 Proteus Digital Health, Inc. Apparatus, system, and method for managing adherence to a regimen
WO2013070914A3 (en) * 2011-11-09 2013-08-08 Proteus Digital Health, Inc. Apparatus, system, and method for managing adherence to a regimen
US9271897B2 (en) 2012-07-23 2016-03-01 Proteus Digital Health, Inc. Techniques for manufacturing ingestible event markers comprising an ingestible component
US11149123B2 (en) 2013-01-29 2021-10-19 Otsuka Pharmaceutical Co., Ltd. Highly-swellable polymeric films and compositions comprising the same
US11744481B2 (en) 2013-03-15 2023-09-05 Otsuka Pharmaceutical Co., Ltd. System, apparatus and methods for data collection and assessing outcomes
US10175376B2 (en) 2013-03-15 2019-01-08 Proteus Digital Health, Inc. Metal detector apparatus, system, and method
US10421658B2 (en) 2013-08-30 2019-09-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
US10398161B2 (en) 2014-01-21 2019-09-03 Proteus Digital Heal Th, Inc. Masticable ingestible product and communication system therefor
US11950615B2 (en) 2014-01-21 2024-04-09 Otsuka Pharmaceutical Co., Ltd. Masticable ingestible product and communication system therefor
US11051543B2 (en) 2015-07-21 2021-07-06 Otsuka Pharmaceutical Co. Ltd. Alginate on adhesive bilayer laminate film
US10187121B2 (en) 2016-07-22 2019-01-22 Proteus Digital Health, Inc. Electromagnetic sensing and detection of ingestible event markers
US10797758B2 (en) 2016-07-22 2020-10-06 Proteus Digital Health, Inc. Electromagnetic sensing and detection of ingestible event markers
US11529071B2 (en) 2016-10-26 2022-12-20 Otsuka Pharmaceutical Co., Ltd. Methods for manufacturing capsules with ingestible event markers
US11793419B2 (en) 2016-10-26 2023-10-24 Otsuka Pharmaceutical Co., Ltd. Methods for manufacturing capsules with ingestible event markers

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GB9708097D0 (en) 1997-06-11

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