WO1997038730A3 - Radioactivity local delivery system - Google Patents

Radioactivity local delivery system Download PDF

Info

Publication number
WO1997038730A3
WO1997038730A3 PCT/CA1997/000262 CA9700262W WO9738730A3 WO 1997038730 A3 WO1997038730 A3 WO 1997038730A3 CA 9700262 W CA9700262 W CA 9700262W WO 9738730 A3 WO9738730 A3 WO 9738730A3
Authority
WO
WIPO (PCT)
Prior art keywords
radioactivity
delivery system
radioisotope
coupled
local delivery
Prior art date
Application number
PCT/CA1997/000262
Other languages
French (fr)
Other versions
WO1997038730A2 (en
Inventor
Olivier Bertrand
Rosaire Mongrain
Jean-Francois Tanguay
Luc Bilodeau
Original Assignee
Olivier Bertrand
Rosaire Mongrain
Tanguay Jean Francois
Luc Bilodeau
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olivier Bertrand, Rosaire Mongrain, Tanguay Jean Francois, Luc Bilodeau filed Critical Olivier Bertrand
Priority to AU25011/97A priority Critical patent/AU2501197A/en
Priority to EP97916290A priority patent/EP0894012A2/en
Publication of WO1997038730A2 publication Critical patent/WO1997038730A2/en
Publication of WO1997038730A3 publication Critical patent/WO1997038730A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1002—Intraluminal radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0095—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof radioactive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Abstract

The invention provides a radioactivity local delivery system enabling the use of isotopes having a longer half life and having a lower energy. The invention also provides a radioactivity local delivery system enabling an easier and more efficient control of the dose/rate and total dose of local radiation delivery. The present invention utilizes a radioisotope coupled to a circulation time reducing agent such as a chelatin agent, the coupled radioisotope being in releasable association with the structure to be inserted in a vessel of a human patient. The coupled radioisotope can be part of the support itself or in releasable association therewith through the use of a biodegradable or non-biodegradable pharmaceutical carrier. Also provided is a method to decrease the growth of actively proliferating cells at a targeted site in a vessel of a human patient as well as compositions therefor.
PCT/CA1997/000262 1996-04-17 1997-04-17 Radioactivity local delivery system WO1997038730A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU25011/97A AU2501197A (en) 1996-04-17 1997-04-17 Radioactivity local delivery system
EP97916290A EP0894012A2 (en) 1996-04-17 1997-04-17 Radioactivity local delivery system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1578896P 1996-04-17 1996-04-17
US60/015,788 1996-04-17

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US09171384 A-371-Of-International 1999-02-16
US09/851,801 Continuation-In-Part US6736769B2 (en) 1996-04-17 2001-05-09 Radioactivity local delivery system
US09/851,801 Continuation US6736769B2 (en) 1996-04-17 2001-05-09 Radioactivity local delivery system

Publications (2)

Publication Number Publication Date
WO1997038730A2 WO1997038730A2 (en) 1997-10-23
WO1997038730A3 true WO1997038730A3 (en) 1997-12-11

Family

ID=21773647

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1997/000262 WO1997038730A2 (en) 1996-04-17 1997-04-17 Radioactivity local delivery system

Country Status (3)

Country Link
EP (1) EP0894012A2 (en)
AU (1) AU2501197A (en)
WO (1) WO1997038730A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5871436A (en) * 1996-07-19 1999-02-16 Advanced Cardiovascular Systems, Inc. Radiation therapy method and device
US5924973A (en) 1996-09-26 1999-07-20 The Trustees Of Columbia University In The City Of New York Method of treating a disease process in a luminal structure
DK0996471T3 (en) 1997-04-26 2004-05-03 Univ Karlsruhe Radionuclide microparticles bound to elastomeric tubing for endovascular therapy
DE19718339A1 (en) * 1997-04-30 1998-11-12 Schering Ag Polymer coated stents, processes for their manufacture and their use for restenosis prophylaxis
US6106454A (en) * 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
JP2001516730A (en) * 1997-09-18 2001-10-02 シェリング アクチェンゲゼルシャフト Methods for therapeutically treating proliferative disorders
US6129658A (en) * 1997-12-10 2000-10-10 Varian Associates, Inc. Method and apparatus creating a radioactive layer on a receiving substrate for in vivo implantation
DE19819635A1 (en) * 1998-05-05 1999-11-11 Jomed Implantate Gmbh Radioactive stent
DE19853067A1 (en) * 1998-11-17 2000-05-18 Jomed Implantate Gmbh Radioactive stent
US6296603B1 (en) * 1998-05-26 2001-10-02 Isostent, Inc. Radioactive intraluminal endovascular prosthesis and method for the treatment of aneurysms
ES2247826T3 (en) * 1998-09-29 2006-03-01 C.R. Bard Inc. MEDICINES ADMINISTRATION SYSTEMS.
US6251079B1 (en) 1998-09-30 2001-06-26 C. R. Bard, Inc. Transthoracic drug delivery device
US6620170B1 (en) 1999-04-26 2003-09-16 C. R. Bard, Inc. Devices and methods for treating ischemia by creating a fibrin plug
US6719805B1 (en) 1999-06-09 2004-04-13 C. R. Bard, Inc. Devices and methods for treating tissue
US6277082B1 (en) 1999-07-22 2001-08-21 C. R. Bard, Inc. Ischemia detection system
US6629987B1 (en) 1999-07-30 2003-10-07 C. R. Bard, Inc. Catheter positioning systems
FR2797175A1 (en) * 1999-08-02 2001-02-09 Jacques Seguin Device for treatment of narrowing of vascular blood vessel or bilious duct, comprises catheter, radially extensible tubular element called stent, mounted on catheter, and means of expansion and radial deployment of stent

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0433011A1 (en) * 1989-12-11 1991-06-19 Robert E. Fischell Intra-arterial stent with the capability to inhibit intimal hyperplasia
US5176617A (en) * 1989-12-11 1993-01-05 Medical Innovative Technologies R & D Limited Partnership Use of a stent with the capability to inhibit malignant growth in a vessel such as a biliary duct
DE4315002C1 (en) * 1993-05-06 1994-08-18 Kernforschungsz Karlsruhe Vascular implant
US5383928A (en) * 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
WO1995009659A1 (en) * 1993-10-06 1995-04-13 Marvin Slepian Local polymeric gel cellular therapy
WO1995019167A1 (en) * 1994-01-14 1995-07-20 Mallinckrodt Medical, Inc. Therapeutic treatment for inhibiting vascular restenosis

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0433011A1 (en) * 1989-12-11 1991-06-19 Robert E. Fischell Intra-arterial stent with the capability to inhibit intimal hyperplasia
US5176617A (en) * 1989-12-11 1993-01-05 Medical Innovative Technologies R & D Limited Partnership Use of a stent with the capability to inhibit malignant growth in a vessel such as a biliary duct
US5383928A (en) * 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
DE4315002C1 (en) * 1993-05-06 1994-08-18 Kernforschungsz Karlsruhe Vascular implant
WO1995009659A1 (en) * 1993-10-06 1995-04-13 Marvin Slepian Local polymeric gel cellular therapy
WO1995019167A1 (en) * 1994-01-14 1995-07-20 Mallinckrodt Medical, Inc. Therapeutic treatment for inhibiting vascular restenosis

Also Published As

Publication number Publication date
WO1997038730A2 (en) 1997-10-23
EP0894012A2 (en) 1999-02-03
AU2501197A (en) 1997-11-07

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