WO1997032653A1 - Selective membrane/sorption techniques for salvaging blood - Google Patents
Selective membrane/sorption techniques for salvaging blood Download PDFInfo
- Publication number
- WO1997032653A1 WO1997032653A1 PCT/US1997/004126 US9704126W WO9732653A1 WO 1997032653 A1 WO1997032653 A1 WO 1997032653A1 US 9704126 W US9704126 W US 9704126W WO 9732653 A1 WO9732653 A1 WO 9732653A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- plasma
- blood
- solute
- plasma chamber
- hemoconcentrator
- Prior art date
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 233
- 239000008280 blood Substances 0.000 title claims abstract description 233
- 239000012528 membrane Substances 0.000 title claims abstract description 153
- 238000000034 method Methods 0.000 title claims abstract description 57
- 238000001179 sorption measurement Methods 0.000 title description 4
- 239000002594 sorbent Substances 0.000 claims abstract description 100
- 239000012510 hollow fiber Substances 0.000 claims abstract description 77
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 59
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 54
- 239000012530 fluid Substances 0.000 claims abstract description 43
- 230000027455 binding Effects 0.000 claims abstract description 16
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 32
- 229960002897 heparin Drugs 0.000 claims description 32
- 229920000669 heparin Polymers 0.000 claims description 32
- 206010018873 Haemoconcentration Diseases 0.000 claims description 28
- 210000004027 cell Anatomy 0.000 claims description 26
- 239000011148 porous material Substances 0.000 claims description 23
- 239000000463 material Substances 0.000 claims description 19
- 230000008878 coupling Effects 0.000 claims description 16
- 238000010168 coupling process Methods 0.000 claims description 16
- 238000005859 coupling reaction Methods 0.000 claims description 16
- 210000000601 blood cell Anatomy 0.000 claims description 12
- -1 polypropylene Polymers 0.000 claims description 12
- 239000003446 ligand Substances 0.000 claims description 11
- 239000000758 substrate Substances 0.000 claims description 10
- 229920000936 Agarose Polymers 0.000 claims description 8
- 229920001747 Cellulose diacetate Polymers 0.000 claims description 8
- 229920002492 poly(sulfone) Polymers 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 239000004743 Polypropylene Substances 0.000 claims description 5
- 210000001772 blood platelet Anatomy 0.000 claims description 5
- 239000003792 electrolyte Substances 0.000 claims description 5
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 5
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 5
- 229920001155 polypropylene Polymers 0.000 claims description 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 5
- 229920002284 Cellulose triacetate Polymers 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090001090 Lectins Proteins 0.000 claims description 4
- 102000004856 Lectins Human genes 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 claims description 4
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 235000014633 carbohydrates Nutrition 0.000 claims description 4
- 229920002301 cellulose acetate Polymers 0.000 claims description 4
- 239000002738 chelating agent Substances 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 239000002523 lectin Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 229920002239 polyacrylonitrile Polymers 0.000 claims description 4
- 239000004417 polycarbonate Substances 0.000 claims description 4
- 229920000515 polycarbonate Polymers 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 4
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 4
- 239000004800 polyvinyl chloride Substances 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 229920002521 macromolecule Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 230000000717 retained effect Effects 0.000 claims description 2
- 230000002612 cardiopulmonary effect Effects 0.000 abstract description 6
- 239000000243 solution Substances 0.000 description 38
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 238000005406 washing Methods 0.000 description 9
- 238000007675 cardiac surgery Methods 0.000 description 8
- 238000000926 separation method Methods 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 7
- 230000017531 blood circulation Effects 0.000 description 6
- 238000009530 blood pressure measurement Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 238000011110 re-filtration Methods 0.000 description 6
- 238000011160 research Methods 0.000 description 6
- 239000003053 toxin Substances 0.000 description 6
- 231100000765 toxin Toxicity 0.000 description 6
- 108700012359 toxins Proteins 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 210000000038 chest Anatomy 0.000 description 5
- 230000015271 coagulation Effects 0.000 description 5
- 238000005345 coagulation Methods 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- 102000004506 Blood Proteins Human genes 0.000 description 4
- 108010017384 Blood Proteins Proteins 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 108010054147 Hemoglobins Proteins 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 102000007330 LDL Lipoproteins Human genes 0.000 description 3
- 108010007622 LDL Lipoproteins Proteins 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 239000010836 blood and blood product Substances 0.000 description 3
- 229940125691 blood product Drugs 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 230000008718 systemic inflammatory response Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000002615 hemofiltration Methods 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000010412 perfusion Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- 108010039627 Aprotinin Proteins 0.000 description 1
- 108010031093 Deltran Proteins 0.000 description 1
- 208000003870 Drug Overdose Diseases 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 108010093096 Immobilized Enzymes Proteins 0.000 description 1
- 108010058683 Immobilized Proteins Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 206010033296 Overdoses Diseases 0.000 description 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229960004405 aprotinin Drugs 0.000 description 1
- 239000003833 bile salt Substances 0.000 description 1
- 229940093761 bile salts Drugs 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- HGAZMNJKRQFZKS-UHFFFAOYSA-N chloroethene;ethenyl acetate Chemical compound ClC=C.CC(=O)OC=C HGAZMNJKRQFZKS-UHFFFAOYSA-N 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000000385 dialysis solution Substances 0.000 description 1
- 231100000725 drug overdose Toxicity 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 210000005228 liver tissue Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000002616 plasmapheresis Methods 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000004382 potting Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3427—Substitution fluid path back through the membrane, e.g. by inverted trans-membrane pressure [TMP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3475—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate with filtrate treatment agent in the same enclosure as the membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3482—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate by filtrating the filtrate using another cross-flow filter, e.g. a membrane filter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3493—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate using treatment agents in suspension
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
- A61M1/3603—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in the same direction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
- B01D61/146—Ultrafiltration comprising multiple ultrafiltration steps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/243—Dialysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
- B01D63/04—Hollow fibre modules comprising multiple hollow fibre assemblies
- B01D63/046—Hollow fibre modules comprising multiple hollow fibre assemblies in separate housings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3672—Means preventing coagulation
- A61M1/3675—Deactivation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/40—Adsorbents within the flow path
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/06—Submerged-type; Immersion type
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Water Supply & Treatment (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97915100A EP0892664A4 (en) | 1996-03-08 | 1997-03-07 | Selective membrane/sorption techniques for salvaging blood |
AU22128/97A AU2212897A (en) | 1996-03-08 | 1997-03-07 | Selective membrane/sorption techniques for salvaging blood |
JP53203997A JP2001524839A (en) | 1996-03-08 | 1997-03-07 | Collection of autologous blood by selective membrane / adsorption technique |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1313596P | 1996-03-08 | 1996-03-08 | |
US60/013,135 | 1996-03-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997032653A1 true WO1997032653A1 (en) | 1997-09-12 |
Family
ID=21758493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/004126 WO1997032653A1 (en) | 1996-03-08 | 1997-03-07 | Selective membrane/sorption techniques for salvaging blood |
Country Status (6)
Country | Link |
---|---|
US (1) | US5858238A (en) |
EP (1) | EP0892664A4 (en) |
JP (1) | JP2001524839A (en) |
AU (1) | AU2212897A (en) |
CA (1) | CA2247031A1 (en) |
WO (1) | WO1997032653A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999025463A1 (en) * | 1997-11-14 | 1999-05-27 | Massachusetts Institute Of Technology | Apparatus and method for treating whole blood |
WO1999047190A1 (en) * | 1998-03-16 | 1999-09-23 | Medtronic, Inc. | Hemostatic system and components for extracorporeal circuit |
WO2002013888A1 (en) * | 2000-08-15 | 2002-02-21 | Heim Medizintechnik Gmbh | Filter arrangement for the separation of blood into plasma and cellular components and device for application thereof on the donor |
EP1382360A1 (en) * | 2002-07-15 | 2004-01-21 | DIDECO S.p.A. | Hemoconcentrator in extracorporeal blood circuit |
US7795010B2 (en) | 2004-01-21 | 2010-09-14 | Toray Industries, Inc. | Fractionator and method of fractionation |
RU2641173C1 (en) * | 2016-10-31 | 2018-01-16 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний" (НИИ КПССЗ) | Method for prevention of development of systemic inflammatory response in cardiac-surgical patients after artificial circulation |
Families Citing this family (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPN030794A0 (en) | 1994-12-22 | 1995-01-27 | Aruba International Pty Ltd | Discontinuous plasma or serum delipidation |
US7033334B2 (en) * | 1996-09-24 | 2006-04-25 | Samolyk Keith A | Hemo-concentrator system for autologous blood recovery |
US5928178A (en) * | 1996-09-24 | 1999-07-27 | Samolyk; Keith | Cardiopulmonary bypass blood recovery method and hemo-bag |
US6579253B1 (en) | 1997-02-14 | 2003-06-17 | Nxstage Medical, Inc. | Fluid processing systems and methods using extracorporeal fluid flow panels oriented within a cartridge |
US6673314B1 (en) | 1997-02-14 | 2004-01-06 | Nxstage Medical, Inc. | Interactive systems and methods for supporting hemofiltration therapies |
US6638478B1 (en) | 1997-02-14 | 2003-10-28 | Nxstage Medical, Inc. | Synchronized volumetric fluid balancing systems and methods |
US6830553B1 (en) | 1997-02-14 | 2004-12-14 | Nxstage Medical, Inc. | Blood treatment systems and methods that maintain sterile extracorporeal processing conditions |
WO2001037786A2 (en) * | 1997-02-14 | 2001-05-31 | Nxstage Medical, Inc. | Fluid processing systems and methods using extracorporeal fluid flow panels oriented within a cartridge |
US20010016699A1 (en) | 1997-02-14 | 2001-08-23 | Jeffrey H. Burbank | Hemofiltration system |
US6554789B1 (en) | 1997-02-14 | 2003-04-29 | Nxstage Medical, Inc. | Layered fluid circuit assemblies and methods for making them |
US20040243047A1 (en) * | 1997-02-14 | 2004-12-02 | Brugger James M. | Single step fluid circuit engagement device and method |
US6638477B1 (en) | 1997-02-14 | 2003-10-28 | Nxstage Medical, Inc. | Fluid replacement systems and methods for use in hemofiltration |
US6852090B2 (en) * | 1997-02-14 | 2005-02-08 | Nxstage Medical, Inc. | Fluid processing systems and methods using extracorporeal fluid flow panels oriented within a cartridge |
US6595943B1 (en) | 1997-02-14 | 2003-07-22 | Nxstage Medical, Inc. | Systems and methods for controlling blood flow and waste fluid removal during hemofiltration |
US6287516B1 (en) | 1998-07-10 | 2001-09-11 | Immunocept, L.L.C. | Hemofiltration systems, methods, and devices used to treat inflammatory mediator related disease |
US20040199099A1 (en) * | 1998-07-10 | 2004-10-07 | Matson James R | Hemofiltration systems, methods and devices used to treat inflammatory mediator related disease |
JP4638986B2 (en) | 1998-10-16 | 2011-02-23 | テルモ メディカル コーポレイション | Blood processing equipment |
US7780619B2 (en) * | 1999-11-29 | 2010-08-24 | Nxstage Medical, Inc. | Blood treatment apparatus |
AU2001249996A1 (en) * | 2000-02-22 | 2001-09-03 | Dudley Spencer | Hemodialysis assembly and method |
US6719717B1 (en) | 2000-03-17 | 2004-04-13 | Advanced Research & Technology Institute, Inc. | Thrombectomy treatment system and method |
US7291122B2 (en) * | 2000-03-24 | 2007-11-06 | Immunocept, L.L.C. | Hemofiltration methods for treatment of diseases in a mammal |
US6736972B1 (en) | 2000-03-24 | 2004-05-18 | Immunocept, L.L.C. | Method and system for providing therapeutic agents with hemofiltration for reducing inflammatory mediator related diseases |
AU2001259469A1 (en) * | 2000-05-05 | 2001-11-20 | Hemocleanse, Inc. | Use of magnetic particles or other particles having relatively high density in afluid for mixing and/or leak detection |
US6787040B2 (en) * | 2000-05-16 | 2004-09-07 | Immunocept, L.L.C. | Method and system for colloid exchange therapy |
AUPQ846900A0 (en) * | 2000-06-29 | 2000-07-27 | Aruba International Pty Ltd | A vaccine |
US7407662B2 (en) * | 2000-06-29 | 2008-08-05 | Lipid Sciences, Inc. | Modified viral particles with immunogenic properties and reduced lipid content |
US7439052B2 (en) * | 2000-06-29 | 2008-10-21 | Lipid Sciences | Method of making modified immunodeficiency virus particles |
US7407663B2 (en) * | 2000-06-29 | 2008-08-05 | Lipid Sciences, Inc. | Modified immunodeficiency virus particles |
US20090017069A1 (en) * | 2000-06-29 | 2009-01-15 | Lipid Sciences, Inc. | SARS Vaccine Compositions and Methods of Making and Using Them |
US6776770B1 (en) | 2000-09-07 | 2004-08-17 | Advanced Research & Technology Institute | Thromboaspiration valve-filter device and methods |
US6689615B1 (en) | 2000-10-04 | 2004-02-10 | James Murto | Methods and devices for processing blood samples |
US6582386B2 (en) | 2001-03-06 | 2003-06-24 | Baxter International Inc. | Multi-purpose, automated blood and fluid processing systems and methods |
US6884228B2 (en) | 2001-03-06 | 2005-04-26 | Baxter International Inc. | Automated system adaptable for use with different fluid circuits |
US6706008B2 (en) | 2001-03-06 | 2004-03-16 | Baxter International Inc. | Automated system and method for withdrawing compounds from blood |
CA2449468A1 (en) * | 2001-06-04 | 2002-12-12 | Albert Einstein Healthcare Network | Cardiac stimulating apparatus having a blood clot filter and atrial pacer |
EP1412045A4 (en) * | 2001-06-25 | 2007-05-02 | Lipid Sciences Inc | Systems and methods using a solvent for the removal of lipids from fluids |
US20060060520A1 (en) * | 2001-06-25 | 2006-03-23 | Bomberger David C | Systems and methods using a solvent for the removal of lipids from fluids |
EP1409108A4 (en) * | 2001-06-25 | 2007-11-14 | Lipid Sciences Inc | Hollow fiber contactor systems for removal of lipids from fluids |
WO2003000381A1 (en) | 2001-06-25 | 2003-01-03 | Lipid Sciences, Inc. | Hollow fiber contactor systems for removal of lipids from fluids |
US6991727B2 (en) * | 2001-06-25 | 2006-01-31 | Lipid Sciences, Inc. | Hollow fiber contactor systems for removal of lipids from fluids |
AU2002319690A1 (en) * | 2001-07-25 | 2003-02-17 | Immunocept, L.L.C. | Hemofiltration systems, methods and devices used to treat inflammatory mediator related disease |
US20030036720A1 (en) * | 2001-08-17 | 2003-02-20 | Spencer Dudley W.C. | Hemodialysis assembly and method |
US7241272B2 (en) | 2001-11-13 | 2007-07-10 | Baxter International Inc. | Method and composition for removing uremic toxins in dialysis processes |
US6649072B2 (en) | 2001-11-16 | 2003-11-18 | Robert Brandt | Method for producing autologous platelet-rich plasma |
US6852231B2 (en) * | 2002-02-15 | 2005-02-08 | Denco, Inc. | Spin-hemodialysis assembly and method |
US20030220607A1 (en) * | 2002-05-24 | 2003-11-27 | Don Busby | Peritoneal dialysis apparatus |
US7175606B2 (en) | 2002-05-24 | 2007-02-13 | Baxter International Inc. | Disposable medical fluid unit having rigid frame |
US7153286B2 (en) | 2002-05-24 | 2006-12-26 | Baxter International Inc. | Automated dialysis system |
JP4460448B2 (en) * | 2002-07-19 | 2010-05-12 | バクスター・インターナショナル・インコーポレイテッド | System and method for peritoneal dialysis |
JP2005533560A (en) * | 2002-07-19 | 2005-11-10 | バクスター インターナショナル インコーポレイテッド | System and method for performing peritoneal dialysis |
MXPA05000816A (en) | 2002-07-19 | 2005-04-28 | Baxter Int | Systems and methods for performing peritoneal dialysis. |
US7238164B2 (en) * | 2002-07-19 | 2007-07-03 | Baxter International Inc. | Systems, methods and apparatuses for pumping cassette-based therapies |
KR20050083627A (en) * | 2002-08-13 | 2005-08-26 | 아비오스 테크놀러지스 인코포레이티드 | Selective plasma exchange therapy |
JP2005538148A (en) * | 2002-08-26 | 2005-12-15 | リピド サイエンスィズ インコーポレイテッド | Treatment of Alzheimer's disease using defatted protein particles |
ITFI20020208A1 (en) * | 2002-10-31 | 2004-05-01 | Torre Florenziano Della | EQUIPMENT USED IN HEMOFILTRATION TREATMENTS. |
DE10256848A1 (en) * | 2002-12-04 | 2004-07-08 | Sibylle Latza | Method and device for separating whole blood under gravity into an erythrocyte concentrate and plasma |
US7169303B2 (en) * | 2003-05-28 | 2007-01-30 | Hemocleanse Technologies, Llc | Sorbent reactor for extracorporeal blood treatment systems, peritoneal dialysis systems, and other body fluid treatment systems |
US7393826B2 (en) | 2003-07-03 | 2008-07-01 | Lipid Sciences, Inc. | Methods and apparatus for creating particle derivatives of HDL with reduced lipid content |
JP2007527387A (en) * | 2003-07-03 | 2007-09-27 | リピッド サイエンシーズ,インコーポレイテッド | Method and apparatus for producing particle derivatives of HDL with reduced lipid content |
US6960803B2 (en) * | 2003-10-23 | 2005-11-01 | Silicon Storage Technology, Inc. | Landing pad for use as a contact to a conductive spacer |
US8029454B2 (en) | 2003-11-05 | 2011-10-04 | Baxter International Inc. | High convection home hemodialysis/hemofiltration and sorbent system |
JP2005232156A (en) * | 2004-01-21 | 2005-09-02 | Toray Ind Inc | Solution of purified component of living body,method for separating the component of the living body and apparatus for separating the component of the living body |
JP2005320322A (en) * | 2004-04-08 | 2005-11-17 | Toray Ind Inc | Fractionation apparatus |
US7964338B2 (en) * | 2005-01-12 | 2011-06-21 | Biovec Transfusion, Llc | Platelet preservation composition containing eptifibatide, a reversible factor IIa inhibitor and a hemoglobin oxygen carrier |
US8142992B2 (en) * | 2005-01-12 | 2012-03-27 | Biovec Transfusion, Llc | Platelet preservation package comprising a short to ultra-short acting antiplatelet agent and anticoagulant with an oxygen carrier |
US20100221697A1 (en) * | 2005-01-12 | 2010-09-02 | BioVec Transfusions, LLC | Composition for preserving platelets and method of using and storing the same |
US8129104B2 (en) * | 2005-01-12 | 2012-03-06 | Biovec Transfusion, Llc | Platelet preservation composition comprising a short to ultra-short acting antiplatelet agent and anticoagulant with hemoglobin |
US8431334B2 (en) * | 2006-01-12 | 2013-04-30 | Biovec Transfusion, Llc | Method for removing antiplatelet agent and anticoagulant from a platelet composition by diafiltration |
US9095818B2 (en) | 2009-06-15 | 2015-08-04 | Biovec Transfusion, Llc | Method of filtering platelets to remove antiplatelet and anticoagulant agents |
US20080319369A1 (en) * | 2007-06-22 | 2008-12-25 | George Trutza | Systems and Methods for Removing Fluid and Atherogenic, Thrombotic, and Inflammatory Markers From Blood |
US8685258B2 (en) * | 2008-02-27 | 2014-04-01 | Fenwal, Inc. | Systems and methods for conveying multiple blood components to a recipient |
US8075468B2 (en) * | 2008-02-27 | 2011-12-13 | Fenwal, Inc. | Systems and methods for mid-processing calculation of blood composition |
CA2721285A1 (en) * | 2008-04-15 | 2009-10-22 | Gambro Lundia Ab | Blood treatment apparatus |
GB0809092D0 (en) * | 2008-05-20 | 2008-06-25 | Univ Strathclyde | Fluid processing device |
US8057679B2 (en) | 2008-07-09 | 2011-11-15 | Baxter International Inc. | Dialysis system having trending and alert generation |
US8062513B2 (en) | 2008-07-09 | 2011-11-22 | Baxter International Inc. | Dialysis system and machine having therapy prescription recall |
US9514283B2 (en) | 2008-07-09 | 2016-12-06 | Baxter International Inc. | Dialysis system having inventory management including online dextrose mixing |
US9997325B2 (en) | 2008-07-17 | 2018-06-12 | Verity Instruments, Inc. | Electron beam exciter for use in chemical analysis in processing systems |
US20100051552A1 (en) | 2008-08-28 | 2010-03-04 | Baxter International Inc. | In-line sensors for dialysis applications |
CA2766670C (en) | 2009-11-17 | 2018-07-10 | Brightwake Limited | Device and method for processing fluid |
US8753515B2 (en) | 2009-12-05 | 2014-06-17 | Home Dialysis Plus, Ltd. | Dialysis system with ultrafiltration control |
US8501009B2 (en) | 2010-06-07 | 2013-08-06 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Fluid purification system |
RU2445126C1 (en) * | 2010-11-19 | 2012-03-20 | Учреждение Российской академии медицинских наук Научно-исследовательский институт кардиологии Сибирского отделения РАМН | Method for modified blood ultrafiltration in artificial circulation in infants |
WO2013052680A2 (en) | 2011-10-07 | 2013-04-11 | Home Dialysis Plus, Ltd. | Heat exchange fluid purification for dialysis system |
CN102512955A (en) * | 2011-11-03 | 2012-06-27 | 深圳市普特生物医学工程有限公司 | Blood separating column |
US20140271358A1 (en) * | 2013-03-13 | 2014-09-18 | Keith Samolyk | CPB Pump System With Double Y Tubing |
US9327066B2 (en) * | 2013-03-13 | 2016-05-03 | Keith Samolyk | CPB system with dual function blood reservoir |
US20140263065A1 (en) * | 2013-03-13 | 2014-09-18 | Keith Samolyk | Method Of Controlling Blood Reservoir Volume And Flow In An Extracorporeal Blood Circulation System |
US9452253B2 (en) | 2013-03-13 | 2016-09-27 | Keith Samolyk | CPB system with fluid volume control |
WO2015168280A1 (en) | 2014-04-29 | 2015-11-05 | Outset Medical, Inc. | Dialysis system and methods |
EP3307344A4 (en) * | 2015-06-15 | 2019-04-17 | Vital Therapies, Inc. | System and method for extracorporeal blood treatment |
CN116206744A (en) | 2015-06-25 | 2023-06-02 | 甘布罗伦迪亚股份公司 | Medical device systems and methods with distributed databases |
US10786615B2 (en) * | 2016-03-02 | 2020-09-29 | Exthera Medical Corporation | Method for treating drug intoxication |
US11911551B2 (en) | 2016-03-02 | 2024-02-27 | Exthera Medical Corporation | Method for treating drug intoxication |
EP3500317B1 (en) | 2016-08-19 | 2022-02-23 | Outset Medical, Inc. | Peritoneal dialysis system and methods |
US10786614B2 (en) * | 2016-10-24 | 2020-09-29 | Henley Development Corporation | Antigenic decoy entrapment filtration device and treatment methods for autoimmune disorders |
EP3559951B1 (en) | 2016-12-21 | 2022-01-12 | Gambro Lundia AB | Medical device system including information technology infrastructure having secure cluster domain supporting external domain |
WO2019104237A1 (en) | 2017-11-22 | 2019-05-31 | Hdl Therapeutics, Inc. | Systems and methods for priming fluid circuits of a plasma processing system |
BR112020013045A2 (en) | 2017-12-28 | 2020-12-01 | I-Sep | system and method of treating hemorrhagic fluid for autotransfusion |
AU2018396009A1 (en) | 2017-12-28 | 2020-07-16 | Hdl Therapeutics, Inc. | Methods for preserving and administering pre-beta high density lipoprotein extracted from human plasma |
US11007360B2 (en) | 2018-05-01 | 2021-05-18 | Fresenius Medical Care Holdings, Inc. | Multi-purpose cap for fluid ports on a medical device |
JP7315582B2 (en) | 2018-11-27 | 2023-07-26 | テルモ株式会社 | artificial lung |
CN113209709B (en) * | 2021-03-31 | 2022-08-09 | 青岛康景辉环境科技集团有限公司 | Circulating silt-sinking prevention method for evaporative crystallization mother liquid tank |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5211850A (en) * | 1991-07-26 | 1993-05-18 | Research Medical, Inc. | Plasma filter sorbent system for removal of components from blood |
US5277820A (en) * | 1992-02-06 | 1994-01-11 | Hemocleanse, Inc. | Device and method for extracorporeal blood treatment |
US5536412A (en) * | 1992-02-06 | 1996-07-16 | Hemocleanse, Inc. | Hemofiltration and plasmafiltration devices and methods |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4071444A (en) * | 1976-10-12 | 1978-01-31 | Purdue Research Foundation | Portable chemical reactor for use as an artificial kidney |
US4581141A (en) * | 1978-02-27 | 1986-04-08 | Purdue Research Foundation | Dialysis material and method for removing uremic substances |
US4348283A (en) * | 1980-11-05 | 1982-09-07 | Purdue Research Foundation | Reciprocating dialyzer having spacers |
US4661246A (en) * | 1984-10-01 | 1987-04-28 | Ash Medical Systems, Inc. | Dialysis instrument with dialysate side pump for moving body fluids |
US4995268A (en) * | 1989-09-01 | 1991-02-26 | Ash Medical System, Incorporated | Method and apparatus for determining a rate of flow of blood for an extracorporeal blood therapy instrument |
-
1997
- 1997-03-07 US US08/813,504 patent/US5858238A/en not_active Expired - Fee Related
- 1997-03-07 AU AU22128/97A patent/AU2212897A/en not_active Abandoned
- 1997-03-07 WO PCT/US1997/004126 patent/WO1997032653A1/en not_active Application Discontinuation
- 1997-03-07 JP JP53203997A patent/JP2001524839A/en active Pending
- 1997-03-07 EP EP97915100A patent/EP0892664A4/en not_active Withdrawn
- 1997-03-08 CA CA002247031A patent/CA2247031A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5211850A (en) * | 1991-07-26 | 1993-05-18 | Research Medical, Inc. | Plasma filter sorbent system for removal of components from blood |
US5277820A (en) * | 1992-02-06 | 1994-01-11 | Hemocleanse, Inc. | Device and method for extracorporeal blood treatment |
US5536412A (en) * | 1992-02-06 | 1996-07-16 | Hemocleanse, Inc. | Hemofiltration and plasmafiltration devices and methods |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999025463A1 (en) * | 1997-11-14 | 1999-05-27 | Massachusetts Institute Of Technology | Apparatus and method for treating whole blood |
US6099730A (en) * | 1997-11-14 | 2000-08-08 | Massachusetts Institute Of Technology | Apparatus for treating whole blood comprising concentric cylinders defining an annulus therebetween |
WO1999047190A1 (en) * | 1998-03-16 | 1999-09-23 | Medtronic, Inc. | Hemostatic system and components for extracorporeal circuit |
US6733471B1 (en) | 1998-03-16 | 2004-05-11 | Medtronic, Inc. | Hemostatic system and components for extracorporeal circuit |
US7153473B2 (en) | 1998-03-16 | 2006-12-26 | Medtronic, Inc. | Hemostatic system and components for extracorporeal circuit |
WO2002013888A1 (en) * | 2000-08-15 | 2002-02-21 | Heim Medizintechnik Gmbh | Filter arrangement for the separation of blood into plasma and cellular components and device for application thereof on the donor |
JP2004505731A (en) * | 2000-08-15 | 2004-02-26 | ハイム メディツィンテヒニーク ゲゼルシャフト ミット ベシュレンクテル ハフツング | Filter device for separating blood into plasma and cellular components and device for using the device with a donor |
US7025881B2 (en) | 2000-08-15 | 2006-04-11 | Heim Medizintechnik Gmbh | Filter arrangement for the separation of blood into plasma and cellular components and device for application thereof on the donor |
EP1382360A1 (en) * | 2002-07-15 | 2004-01-21 | DIDECO S.p.A. | Hemoconcentrator in extracorporeal blood circuit |
US7063816B2 (en) | 2002-07-15 | 2006-06-20 | Sorin Group Italia S.R.L. | Hemoconcentrator in extracorporeal blood circuit |
US7795010B2 (en) | 2004-01-21 | 2010-09-14 | Toray Industries, Inc. | Fractionator and method of fractionation |
RU2641173C1 (en) * | 2016-10-31 | 2018-01-16 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний" (НИИ КПССЗ) | Method for prevention of development of systemic inflammatory response in cardiac-surgical patients after artificial circulation |
Also Published As
Publication number | Publication date |
---|---|
CA2247031A1 (en) | 1997-09-12 |
EP0892664A1 (en) | 1999-01-27 |
EP0892664A4 (en) | 1999-09-15 |
AU2212897A (en) | 1997-09-22 |
JP2001524839A (en) | 2001-12-04 |
US5858238A (en) | 1999-01-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5858238A (en) | Salvage of autologous blood via selective membrane/sorption technologies | |
EP0643614B1 (en) | A plasma filter sorbent system for removal of components from blood; improved mass transport system | |
US7169303B2 (en) | Sorbent reactor for extracorporeal blood treatment systems, peritoneal dialysis systems, and other body fluid treatment systems | |
EP0739234B1 (en) | Hemofiltration and plasmafiltration device | |
US5919369A (en) | Hemofiltration and plasmafiltration devices and methods | |
EP0615780B1 (en) | Membrane and method for the separation of protein-bound substances from a protein-containing liquid by dialysis | |
KR102211104B1 (en) | Haemodiafiltration method | |
US20130102948A1 (en) | Portable blood filtration devices, systems, and methods | |
RU2086264C1 (en) | Method and device for clearing blood in patients suffering from renal insufficiency | |
EP2800592A1 (en) | Multi-staged filtration system for blood fluid removal | |
WO2008051994A2 (en) | Fluid-conserving cascade hemofiltration | |
CN105209088A (en) | Device for removing protein-bound toxins from blood plasma | |
Hoenich et al. | Dialysers | |
US20180093032A1 (en) | Targeted apheresis using binding agents or ligands immobilized on membranes | |
EP3563888A1 (en) | Multi-stage blood purification apparatus for removal of toxins | |
de Francisco et al. | Hemodiafiltration with on-line endogenous reinfusion | |
JP4201313B2 (en) | Toxic substance binding albumin removal system | |
Nosé et al. | Hepatic Assist 2: Devices for Use with Sorbents and Biological Reactors | |
JPS6362B2 (en) | ||
Nosé et al. | Plasma filtration detoxification on hepatic patients: its optimal operating conditions | |
JPH09164196A (en) | Method to treat body fluid and instrument using this method | |
JPS59197255A (en) | Removing apparatus | |
RU2152226C1 (en) | Device for sampling and discharging components from liquid media | |
Sato et al. | Characterization of polyethylene membrane for plasma separation | |
JPH07284531A (en) | Device for removing toxic material in blood |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG UZ VN YU AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
ENP | Entry into the national phase |
Ref document number: 2247031 Country of ref document: CA Ref country code: CA Ref document number: 2247031 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1997915100 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref country code: JP Ref document number: 1997 532039 Kind code of ref document: A Format of ref document f/p: F |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 1997915100 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1997915100 Country of ref document: EP |