WO1997028181A3 - Post-labeling stabilization of radiolabeled proteins and peptides - Google Patents

Post-labeling stabilization of radiolabeled proteins and peptides Download PDF

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Publication number
WO1997028181A3
WO1997028181A3 PCT/US1997/001695 US9701695W WO9728181A3 WO 1997028181 A3 WO1997028181 A3 WO 1997028181A3 US 9701695 W US9701695 W US 9701695W WO 9728181 A3 WO9728181 A3 WO 9728181A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
labeling
stabilization
post
radiolabeled proteins
Prior art date
Application number
PCT/US1997/001695
Other languages
French (fr)
Other versions
WO1997028181A2 (en
WO1997028181A9 (en
Inventor
Paul O Zamora
Michael J Marek
Original Assignee
Rhomed Inc
Paul O Zamora
Michael J Marek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhomed Inc, Paul O Zamora, Michael J Marek filed Critical Rhomed Inc
Priority to AU25264/97A priority Critical patent/AU2526497A/en
Priority to CA002279349A priority patent/CA2279349C/en
Publication of WO1997028181A2 publication Critical patent/WO1997028181A2/en
Publication of WO1997028181A3 publication Critical patent/WO1997028181A3/en
Publication of WO1997028181A9 publication Critical patent/WO1997028181A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants

Abstract

The subject invention relates to the use of ascorbic acid and derivatives thereof in stabilizing radiolabeled proteins and peptides against oxidation loss of radiolabel and autoradiolysis. Ascorbic acid is added after radiolabeling, including any required incubation period, but prior to patient administration.
PCT/US1997/001695 1996-02-02 1997-02-03 Post-labeling stabilization of radiolabeled proteins and peptides WO1997028181A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU25264/97A AU2526497A (en) 1996-02-02 1997-02-03 Post-labeling stabilization of radiolabeled proteins and peptides
CA002279349A CA2279349C (en) 1996-02-02 1997-02-03 Ascorbate-stabilized radiopharmaceutical method and composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1102796P 1996-02-02 1996-02-02
US60/011,027 1996-02-02

Publications (3)

Publication Number Publication Date
WO1997028181A2 WO1997028181A2 (en) 1997-08-07
WO1997028181A3 true WO1997028181A3 (en) 1997-10-09
WO1997028181A9 WO1997028181A9 (en) 1998-03-05

Family

ID=21748542

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/001695 WO1997028181A2 (en) 1996-02-02 1997-02-03 Post-labeling stabilization of radiolabeled proteins and peptides

Country Status (3)

Country Link
AU (1) AU2526497A (en)
CA (1) CA2279349C (en)
WO (1) WO1997028181A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8992961B2 (en) 1999-02-08 2015-03-31 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US9526763B2 (en) 2005-02-03 2016-12-27 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US9539200B2 (en) 2005-02-03 2017-01-10 Intarcia Therapeutics Inc. Two-piece, internal-channel osmotic delivery system flow modulator

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
AU2002218751A1 (en) * 2000-07-06 2002-01-21 Bristol-Myers Squibb Pharma Company Stable radiopharmaceutical compositions
MXPA03007595A (en) * 2001-02-26 2003-12-04 Bristol Myers Squibb Pharma Co Ascorbic acid analogs for metalloradiopharmaceuticals.
US7238338B1 (en) 2001-06-22 2007-07-03 Triumf System and method for the large scale labeling of compounds with radiohalogens
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
ES2422864T3 (en) 2006-08-09 2013-09-16 Intarcia Therapeutics, Inc Osmotic release systems and piston units
RU2440097C2 (en) 2007-04-23 2012-01-20 Интарсия Терапьютикс, Инк. Method of treating insulin-independent diabetes and obesity, osmotic delivery system and method for making it
EP2240155B1 (en) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
US20100196272A1 (en) * 2009-01-30 2010-08-05 Neoprobe Corporation Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran
EP3323423B1 (en) 2009-09-28 2020-06-17 Intarcia Therapeutics, Inc Rapid establishment and/or termination of substantial steady-state drug delivery
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
EP3302354B1 (en) 2015-06-03 2023-10-04 i2o Therapeutics, Inc. Implant placement systems
CA3016901C (en) 2016-03-07 2023-06-13 Actinium Pharmaceuticals, Inc. Stabilized radiolabeled anti-cd45 immunoglobulin compositions
WO2017200943A1 (en) 2016-05-16 2017-11-23 Intarcia Therapeutics, Inc. Glucagon-receptor selective polypeptides and methods of use thereof
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
KR20190104039A (en) 2017-01-03 2019-09-05 인타르시아 세라퓨틱스 인코포레이티드 Methods Including Continuous Administration of GLP-1 Receptor Agonists and Co-administration of Drugs

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401646A (en) * 1981-05-08 1983-08-30 University Patents Inc. Method and apparatus for purifying materials radiolabeled with technetium-99m
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5308603A (en) * 1990-03-27 1994-05-03 Thomas Jefferson University Method to directly radiolabel antibodies for diagnostic imaging and therapy
US5384113A (en) * 1991-08-29 1995-01-24 Mallinckrodt Medical, Inc. Stabilizers to prevent autoradiolysis of radiolabeled peptides and proteins
US5405597A (en) * 1991-09-10 1995-04-11 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401646A (en) * 1981-05-08 1983-08-30 University Patents Inc. Method and apparatus for purifying materials radiolabeled with technetium-99m
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5308603A (en) * 1990-03-27 1994-05-03 Thomas Jefferson University Method to directly radiolabel antibodies for diagnostic imaging and therapy
US5384113A (en) * 1991-08-29 1995-01-24 Mallinckrodt Medical, Inc. Stabilizers to prevent autoradiolysis of radiolabeled peptides and proteins
US5405597A (en) * 1991-09-10 1995-04-11 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8992961B2 (en) 1999-02-08 2015-03-31 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US9526763B2 (en) 2005-02-03 2016-12-27 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US9539200B2 (en) 2005-02-03 2017-01-10 Intarcia Therapeutics Inc. Two-piece, internal-channel osmotic delivery system flow modulator

Also Published As

Publication number Publication date
AU2526497A (en) 1997-08-22
WO1997028181A2 (en) 1997-08-07
CA2279349A1 (en) 1997-08-07
CA2279349C (en) 2007-09-25

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