WO1997020198A3 - Method and apparatus for automated image analysis of biological specimens - Google Patents

Method and apparatus for automated image analysis of biological specimens Download PDF

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Publication number
WO1997020198A3
WO1997020198A3 PCT/US1996/019166 US9619166W WO9720198A3 WO 1997020198 A3 WO1997020198 A3 WO 1997020198A3 US 9619166 W US9619166 W US 9619166W WO 9720198 A3 WO9720198 A3 WO 9720198A3
Authority
WO
WIPO (PCT)
Prior art keywords
interest
objects
candidate
images
color space
Prior art date
Application number
PCT/US1996/019166
Other languages
French (fr)
Other versions
WO1997020198A2 (en
Inventor
James W Douglass
Thomas J Riding
James E Ring
Original Assignee
Xl Vision Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21833882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1997020198(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Xl Vision Inc filed Critical Xl Vision Inc
Priority to AU10869/97A priority Critical patent/AU724393B2/en
Priority to AT96940930T priority patent/ATE236386T1/en
Priority to DE69627183T priority patent/DE69627183T2/en
Priority to JP9520726A priority patent/JP2000501184A/en
Priority to EP96940930A priority patent/EP0864082B1/en
Publication of WO1997020198A2 publication Critical patent/WO1997020198A2/en
Publication of WO1997020198A3 publication Critical patent/WO1997020198A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G01N15/1433—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/244—Devices for focusing using image analysis techniques
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/60—Analysis of geometric attributes
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/693—Acquisition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G01N2015/1472—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle with colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1488—Methods for deciding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1497—Particle shape

Abstract

A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images (288) which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space (290). The color space converted image is then low pass filtered (292) and compared to a threshold (294) to remove artifacts and background objects from the candidate object of interest pixels of the color converted image. The candidate object of interest pixels are morphologically processed (296) to group candidate object of interest pixels together into groups which are compared to blob parameters (298) to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objets are acquired at high magnification. The high magnification images are analyzed in the same manner as the low magnification images to confirm the candidate objects of interest which are objects of interest. A high magnification image of each confirmed object of interest is stored for later review and evaluation by a pathologist.
PCT/US1996/019166 1995-11-30 1996-11-27 Method and apparatus for automated image analysis of biological specimens WO1997020198A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU10869/97A AU724393B2 (en) 1995-11-30 1996-11-27 Method and apparatus for automated image analysis of biological specimens
AT96940930T ATE236386T1 (en) 1995-11-30 1996-11-27 METHOD FOR AUTOMATIC IMAGE ANALYSIS OF BIOLOGICAL SAMPLES
DE69627183T DE69627183T2 (en) 1995-11-30 1996-11-27 PROCESS FOR THE AUTOMATIC IMAGE ANALYSIS OF BIOLOGICAL SAMPLES
JP9520726A JP2000501184A (en) 1995-11-30 1996-11-27 Method and apparatus for automatic image analysis of biological specimens
EP96940930A EP0864082B1 (en) 1995-11-30 1996-11-27 Method for automated image analysis of biological specimens

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2680595P 1995-11-30 1995-11-30
US60/026,805 1995-11-30

Publications (2)

Publication Number Publication Date
WO1997020198A2 WO1997020198A2 (en) 1997-06-05
WO1997020198A3 true WO1997020198A3 (en) 1997-08-28

Family

ID=21833882

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/019166 WO1997020198A2 (en) 1995-11-30 1996-11-27 Method and apparatus for automated image analysis of biological specimens

Country Status (8)

Country Link
US (12) US6215892B1 (en)
EP (2) EP1300713A3 (en)
JP (1) JP2000501184A (en)
AT (1) ATE236386T1 (en)
AU (1) AU724393B2 (en)
CA (1) CA2236268A1 (en)
DE (1) DE69627183T2 (en)
WO (1) WO1997020198A2 (en)

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US9535243B2 (en) 2000-05-03 2017-01-03 Leica Biosystems Imaging, Inc. Optimizing virtual slide image quality

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