WO1997008949A3 - Donor kidney viability test for improved preservation - Google Patents

Donor kidney viability test for improved preservation Download PDF

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Publication number
WO1997008949A3
WO1997008949A3 PCT/US1996/014360 US9614360W WO9708949A3 WO 1997008949 A3 WO1997008949 A3 WO 1997008949A3 US 9614360 W US9614360 W US 9614360W WO 9708949 A3 WO9708949 A3 WO 9708949A3
Authority
WO
WIPO (PCT)
Prior art keywords
present
perfusion
contemplates
patency
tubular
Prior art date
Application number
PCT/US1996/014360
Other languages
French (fr)
Other versions
WO1997008949A9 (en
WO1997008949A2 (en
Inventor
Richard W Osgood
Original Assignee
Res Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Corp Technologies Inc filed Critical Res Corp Technologies Inc
Priority to EP96930751A priority Critical patent/EP0876096A2/en
Priority to AU69692/96A priority patent/AU718102B2/en
Publication of WO1997008949A2 publication Critical patent/WO1997008949A2/en
Publication of WO1997008949A3 publication Critical patent/WO1997008949A3/en
Publication of WO1997008949A9 publication Critical patent/WO1997008949A9/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9493—Immunosupressants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0278—Physical preservation processes
    • A01N1/0284—Temperature processes, i.e. using a designated change in temperature over time

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention contemplates a methodology which employs cold perfusion of donor organs with a colloid preservation solution at a selected perfusion pressure which avoids tubular reabsorption and consequent energy loss. The present invention is also directed towards the direct continuous measurement of Glomerular Filtration Rate (GFR) through measurement of urine formation during the perfusion period. The present invention further provides a method to assess afferent arteriole and efferent arteriole vascular patency. The present invention further contemplates the maintenance of tubular patency during perfusion. The present invention is also directed to a method for monitoring cold ischemia damage as an indication for timing and dosage of nephrotoxic immunosuppressant agents, e.g., Cyclosporin A. The present invention still further contemplates a device for performing the test of the present invention.
PCT/US1996/014360 1995-09-08 1996-09-05 Donor kidney viability test for improved preservation WO1997008949A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP96930751A EP0876096A2 (en) 1995-09-08 1996-09-05 Donor kidney viability test for improved preservation
AU69692/96A AU718102B2 (en) 1995-09-08 1996-09-05 Donor kidney viability test for improved preservation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/526,121 1995-09-08
US08/526,121 US5712084A (en) 1995-09-08 1995-09-08 Donor kidney viability test for improved preservation

Publications (3)

Publication Number Publication Date
WO1997008949A2 WO1997008949A2 (en) 1997-03-13
WO1997008949A3 true WO1997008949A3 (en) 1997-04-03
WO1997008949A9 WO1997008949A9 (en) 1997-05-01

Family

ID=24096003

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/014360 WO1997008949A2 (en) 1995-09-08 1996-09-05 Donor kidney viability test for improved preservation

Country Status (5)

Country Link
US (1) US5712084A (en)
EP (1) EP0876096A2 (en)
AU (1) AU718102B2 (en)
CA (1) CA2230474A1 (en)
WO (1) WO1997008949A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673594B1 (en) 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
US6977140B1 (en) * 1998-09-29 2005-12-20 Organ Recovery Systems, Inc. Method for maintaining and/or restoring viability of organs
US7749693B2 (en) * 1998-09-29 2010-07-06 Lifeline Scientific, Inc. Method of determining that an organ is not suitable for transplantation and using it for testing substances
US20020115593A1 (en) * 2000-10-13 2002-08-22 Pike Laboratories, Inc. Organ and biological tissue preservation machine perfusion solution
CA2424073A1 (en) * 2000-10-13 2002-04-18 Maximilian Polyak Organ and biological tissue preservation cold storage solution
CA2521427C (en) * 2003-04-04 2012-11-20 Organ Recovery Systems, Inc. Device for separating gas from a liquid path
US7691622B2 (en) * 2003-04-04 2010-04-06 Lifeline Scientific, Inc. Method and apparatus for transferring heat to or from an organ or tissue container
US7504201B2 (en) * 2004-04-05 2009-03-17 Organ Recovery Systems Method for perfusing an organ and for isolating cells from the organ
US11178866B2 (en) 2011-03-15 2021-11-23 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9426979B2 (en) 2011-03-15 2016-08-30 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
WO2012125782A2 (en) 2011-03-15 2012-09-20 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US9253976B2 (en) 2011-03-15 2016-02-09 Paragonix Technologies, Inc. Methods and devices for preserving tissues
US8828710B2 (en) 2011-03-15 2014-09-09 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9867368B2 (en) 2011-03-15 2018-01-16 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9560846B2 (en) 2012-08-10 2017-02-07 Paragonix Technologies, Inc. System for hypothermic transport of biological samples
US8785116B2 (en) * 2012-08-10 2014-07-22 Paragonix Technologies, Inc. Methods for evaluating the suitability of an organ for transplant
EP3410115A1 (en) * 2013-05-14 2018-12-05 Metabolon, Inc. Tryptophan as a biomarkers for kidney function and methods using the same
US10286036B2 (en) 2017-05-12 2019-05-14 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
WO2018226993A1 (en) 2017-06-07 2018-12-13 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
US11632951B2 (en) 2020-01-31 2023-04-25 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
CA3208563A1 (en) * 2021-02-22 2022-08-25 Johannes HOLZMEISTER Loco-regional perfusion of a kidney

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU665916A1 (en) * 1977-12-22 1979-06-05 Ивановский государственный медицинский институт Method of determining viability of a kidney
SU1496740A1 (en) * 1987-07-13 1989-07-30 Донецкий государственный медицинский институт им.М.Горького Method of determining suitability of transplant for grafting

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4798824A (en) * 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU665916A1 (en) * 1977-12-22 1979-06-05 Ивановский государственный медицинский институт Method of determining viability of a kidney
SU1496740A1 (en) * 1987-07-13 1989-07-30 Донецкий государственный медицинский институт им.М.Горького Method of determining suitability of transplant for grafting

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BIOLOGICAL ABSTRACTS, vol. 63, Philadelphia, PA, US; abstract no. 72409, L.D. MICHELS ET AL.: "Tubular water reabsorption as a viability indicator in the preserved canine kidney." XP002024229 *
BIOLOGICAL ABSTRACTS, vol. 67, Philadelphia, PA, US; abstract no. 25754, E. PROCTOR ET AL.: "An intermittent urinary flow method of assessing viability in warm ischemic kidneys during 48 to 96 hours of perfusion." XP002024230 *
BIOLOGICAL ABSTRACTS, vol. 86, Philadelphia, PA, US; abstract no. 109223, R.J. PLOEG ET AL.: "Succesful 72-hour cold storage of dog kidneys with UW solution." XP002024231 *
DATABASE WPI Section Ch Week 8007, Derwent World Patents Index; Class B04, AN 80-12360C, XP002024232 *
DATABASE WPI Section Ch Week 9019, Derwent World Patents Index; Class D22, AN 90-146486, XP002024233 *
TRANSPLANTATION, vol. 22, no. 5, 1975, pages 522 - 526 *
TRANSPLANTATION, vol. 25, no. 5, 1978, pages 280 - 281 *
TRANSPLANTATION, vol. 46, no. 2, 1988, pages 191 - 196 *

Also Published As

Publication number Publication date
CA2230474A1 (en) 1997-03-13
US5712084A (en) 1998-01-27
AU718102B2 (en) 2000-04-06
AU6969296A (en) 1997-03-27
EP0876096A2 (en) 1998-11-11
WO1997008949A2 (en) 1997-03-13

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