WO1997008190A3 - Compounds - Google Patents

Compounds Download PDF

Info

Publication number
WO1997008190A3
WO1997008190A3 PCT/EP1996/003731 EP9603731W WO9708190A3 WO 1997008190 A3 WO1997008190 A3 WO 1997008190A3 EP 9603731 W EP9603731 W EP 9603731W WO 9708190 A3 WO9708190 A3 WO 9708190A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
combinatorial
relates
particular synthesis
chemistry
Prior art date
Application number
PCT/EP1996/003731
Other languages
French (fr)
Other versions
WO1997008190A2 (en
Inventor
Ian Hughes
Original Assignee
Smithkline Beecham Plc
Ian Hughes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc, Ian Hughes filed Critical Smithkline Beecham Plc
Priority to EP96930092A priority Critical patent/EP0852583A2/en
Priority to JP9509838A priority patent/JPH11513027A/en
Publication of WO1997008190A2 publication Critical patent/WO1997008190A2/en
Publication of WO1997008190A3 publication Critical patent/WO1997008190A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00581—Mass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00592—Split-and-pool, mix-and-divide processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes

Abstract

The invention relates to combinatorial chemistry, in particular synthesis of combinatorial libraries.
PCT/EP1996/003731 1995-08-30 1996-08-23 Compounds WO1997008190A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP96930092A EP0852583A2 (en) 1995-08-30 1996-08-23 Compounds
JP9509838A JPH11513027A (en) 1995-08-30 1996-08-23 Compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9517661.6 1995-08-30
GBGB9517661.6A GB9517661D0 (en) 1995-08-30 1995-08-30 Novel compounds

Publications (2)

Publication Number Publication Date
WO1997008190A2 WO1997008190A2 (en) 1997-03-06
WO1997008190A3 true WO1997008190A3 (en) 1997-03-27

Family

ID=10779919

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/003731 WO1997008190A2 (en) 1995-08-30 1996-08-23 Compounds

Country Status (4)

Country Link
EP (1) EP0852583A2 (en)
JP (1) JPH11513027A (en)
GB (1) GB9517661D0 (en)
WO (1) WO1997008190A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69727466T2 (en) * 1996-04-08 2004-12-16 Glaxo Group Ltd., Greenford MASS-BASED CODING AND QUALITATIVE ANALYSIS OF COMBINATIONAL LIBRARIES
US6004823A (en) * 1997-05-07 1999-12-21 Smithkline Beecham Corporation Compounds
US5908960A (en) * 1997-05-07 1999-06-01 Smithkline Beecham Corporation Compounds
US6207861B1 (en) * 1998-01-05 2001-03-27 Neogenesis, Inc. Method for producing and screening mass coded combinatorial libraries for drug discovery and target validation
EP2241541A1 (en) * 1998-01-05 2010-10-20 Neogenesis, Inc. Method for identifying a member of a mass-coded combinatorial library
EP1728776A3 (en) * 1998-01-05 2006-12-13 Neogenesis, Inc. Method for identifying a member of a mass-coded combinatorial library
JP2002522598A (en) * 1998-08-10 2002-07-23 ザ スクリップス リサーチ インスティテュート Programmable one-pot oligosaccharide synthesis
CA2396755A1 (en) * 2000-02-03 2001-08-09 Nanoscale Combinatorial Synthesis, Inc. Structure identification methods using mass measurements
US6584411B1 (en) 2000-07-26 2003-06-24 Smithkline Beecham Corporation Methods to facilitate the calculation of yields of reaction products
US6576472B1 (en) 2000-07-26 2003-06-10 Smithkline Beecham Corporation Chemical constructs for solution phase chemistry
CA2354921A1 (en) * 2001-05-24 2002-11-24 Yasuo Konishi Drug evolution: drug design at hot spots
US20070048752A1 (en) 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
WO1994008051A1 (en) * 1992-10-01 1994-04-14 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
WO1995004160A1 (en) * 1993-07-30 1995-02-09 Isis Innovation Limited Tag reagent and assay method
WO1995019359A1 (en) * 1994-01-12 1995-07-20 Massachusetts Institute Of Technology Process for making xanthene or cubane based compounds, and protease inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
WO1994008051A1 (en) * 1992-10-01 1994-04-14 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
WO1995004160A1 (en) * 1993-07-30 1995-02-09 Isis Innovation Limited Tag reagent and assay method
WO1995019359A1 (en) * 1994-01-12 1995-07-20 Massachusetts Institute Of Technology Process for making xanthene or cubane based compounds, and protease inhibitors

Also Published As

Publication number Publication date
WO1997008190A2 (en) 1997-03-06
EP0852583A2 (en) 1998-07-15
JPH11513027A (en) 1999-11-09
GB9517661D0 (en) 1995-11-01

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