WO1996042004A3 - Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device - Google Patents

Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device Download PDF

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Publication number
WO1996042004A3
WO1996042004A3 PCT/US1996/008686 US9608686W WO9642004A3 WO 1996042004 A3 WO1996042004 A3 WO 1996042004A3 US 9608686 W US9608686 W US 9608686W WO 9642004 A3 WO9642004 A3 WO 9642004A3
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WIPO (PCT)
Prior art keywords
device array
reaction cells
plate
reservoirs
bottom cell
Prior art date
Application number
PCT/US1996/008686
Other languages
French (fr)
Other versions
WO1996042004A2 (en
Inventor
Satyam C Cherukuri
Robert R Demers
Zhong H Fan
Aaron W Levine
Sterling E Mcbride
Peter J Zanzucchi
Original Assignee
Sarnoff David Res Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Sarnoff David Res Center filed Critical Sarnoff David Res Center
Priority to AU65900/96A priority Critical patent/AU6590096A/en
Publication of WO1996042004A2 publication Critical patent/WO1996042004A2/en
Publication of WO1996042004A3 publication Critical patent/WO1996042004A3/en

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    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Abstract

A system (50) and method for accomplishing a plurality of combinatorial processes in parallel comprising a microelectronic and fluidic array (device array)(100), having reservoirs, connecting microchannels and reaction cells etched into a substrate. The device array is supported by a station which serves to interface and perform electro-optic measurements of material in the reaction cells of the device array. The device array incorporates a modular configuration with three distinct layers or plates. The device array comprises a top feedthru plate, a center distribution plate and a bottom cell plate. The three plates are stacked vertically and coupled together to form a liquid-tight seal. Reservoirs (200), microchannels and reaction cells are controllably etched onto the plates using traditional semiconductor fabrication techniques. The feedthru plate serves as a cover for the device array and contains apertures selectively positioned above the reservoirs located in the center distribution plate. The center distribution plate comprises a plurality of micron sized reservoirs, microchannels (212), reservoir feeds (214), cell feeds and overflow feeds for the distribution of reagent fluids to the reaction cells located in the bottom cell plate. The detachable bottom cell plate serves as a microlaboratory tray of reaction cells. Once the proper reagents or other materials are introduced into the reaction cells, the bottom cell plate is decoupled from the device array and removed for incubation or analysis.
PCT/US1996/008686 1995-06-07 1996-06-07 Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device WO1996042004A2 (en)

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US5603351A (en) 1997-02-18
US6331439B1 (en) 2001-12-18

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