WO1996040098A3 - Prevention and treatment of cardiovascular pathologies with tamoxifen analogues - Google Patents

Prevention and treatment of cardiovascular pathologies with tamoxifen analogues Download PDF

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Publication number
WO1996040098A3
WO1996040098A3 PCT/US1996/010211 US9610211W WO9640098A3 WO 1996040098 A3 WO1996040098 A3 WO 1996040098A3 US 9610211 W US9610211 W US 9610211W WO 9640098 A3 WO9640098 A3 WO 9640098A3
Authority
WO
WIPO (PCT)
Prior art keywords
sup
sub
alkyl
beta
tgf
Prior art date
Application number
PCT/US1996/010211
Other languages
French (fr)
Other versions
WO1996040098A2 (en
Inventor
David J Grainger
James C Metcalfe
Lawrence L Kunz
Paul R Kemp
Robert W Schroff
Peter L Weissberg
Original Assignee
Neorx Corp
David J Grainger
James C Metcalfe
Lawrence L Kunz
Paul R Kemp
Robert W Schroff
Peter L Weissberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/476,735 external-priority patent/US5595722A/en
Priority claimed from US08/486,334 external-priority patent/US5770609A/en
Priority claimed from US08/477,393 external-priority patent/US6395494B1/en
Priority to EP96921577A priority Critical patent/EP0833624B1/en
Priority to CA002223595A priority patent/CA2223595C/en
Priority to DE69637316T priority patent/DE69637316T2/en
Application filed by Neorx Corp, David J Grainger, James C Metcalfe, Lawrence L Kunz, Paul R Kemp, Robert W Schroff, Peter L Weissberg filed Critical Neorx Corp
Priority to JP9502239A priority patent/JPH11510479A/en
Priority to AU62773/96A priority patent/AU6277396A/en
Priority to US08/973,570 priority patent/US6197789B1/en
Publication of WO1996040098A2 publication Critical patent/WO1996040098A2/en
Publication of WO1996040098A3 publication Critical patent/WO1996040098A3/en
Priority to US10/729,056 priority patent/US20060135560A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction

Abstract

A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): wherein Z is C-O or a covalent bond; Y is H or O(C<SUB>1</SUB>-C<SUB>4</SUB>)alkyl, R<SUP>1 </SUP>and R<SUP>2 </SUP>are individually (C<SUB>1</SUB>-C<SUB>4</SUB>)alkyl or together with N are a saturated heterocyclic group, R<SUP>3 </SUP>is ethyl or chloroethyl, R<SUP>4 </SUP>is H, R<SUP>5 </SUP>is I, O(C<SUB>1</SUB>-C<SUB>4</SUB>)alkyl or H and R<SUP>6 </SUP>is I, O(C<SUB>1</SUB>-C<SUB>4</SUB>)alkyl or H with the proviso that when R<SUP>4</SUP>, R<SUP>5</SUP>, and R<SUP>6 </SUP>are H, R<SUP>3 </SUP>is not ethyl; or a pharmaceutically acceptable salt thereof, effective to elevate the level of TGF-beta to treat and/or prevent conditions such as atherosclerosis, thrombosis, myocardial infarction, and stroke is provided. Useful compounds include idoxifene, toremifene or salts thereof. Further provided is a method for identifying an agent that elevates the level of TGF-beta. Another embodiment of the invention is an assay or kit to determine TGF-beta in vitro. Also provided is a therapeutic method comprising inhibiting smooth muscle cell proliferation associated with procedural vascular trauma employing the administration of tamoxifin or structural analogs thereof, including compounds of formula (I).
PCT/US1996/010211 1993-05-13 1996-06-07 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues WO1996040098A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US08/973,570 US6197789B1 (en) 1995-06-07 1996-06-07 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
AU62773/96A AU6277396A (en) 1995-06-07 1996-06-07 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
JP9502239A JPH11510479A (en) 1995-06-07 1996-06-07 Prevention and treatment of cardiovascular disease with tamoxifen analogs
CA002223595A CA2223595C (en) 1995-06-07 1996-06-07 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
DE69637316T DE69637316T2 (en) 1995-06-07 1996-06-07 PREVENTION AND TREATMENT OF CARDIOVASCULAR COMPLAINTS WITH TAMOXIFES ANALOGUE
EP96921577A EP0833624B1 (en) 1995-06-07 1996-06-07 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
US10/729,056 US20060135560A1 (en) 1993-05-13 2003-12-05 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US47893695A 1995-06-07 1995-06-07
US08/476,735 1995-06-07
US08/476,735 US5595722A (en) 1993-01-28 1995-06-07 Method for identifying an agent which increases TGF-beta levels
US08/486,334 1995-06-07
US08/477,393 US6395494B1 (en) 1993-05-13 1995-06-07 Method to determine TGF-β
US08/477,393 1995-06-07
US08/486,334 US5770609A (en) 1993-01-28 1995-06-07 Prevention and treatment of cardiovascular pathologies
US08/478,936 1995-06-07

Related Parent Applications (4)

Application Number Title Priority Date Filing Date
US08/486,334 Continuation-In-Part US5770609A (en) 1992-09-25 1995-06-07 Prevention and treatment of cardiovascular pathologies
US47893695A Continuation-In-Part 1993-05-13 1995-06-07
US08/477,393 Continuation-In-Part US6395494B1 (en) 1992-09-25 1995-06-07 Method to determine TGF-β
US08/476,735 Continuation-In-Part US5595722A (en) 1993-01-28 1995-06-07 Method for identifying an agent which increases TGF-beta levels

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US08/973,570 A-371-Of-International US6197789B1 (en) 1993-05-13 1996-06-07 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
US09/754,775 Continuation US20020068731A1 (en) 1993-05-13 2001-01-04 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues

Publications (2)

Publication Number Publication Date
WO1996040098A2 WO1996040098A2 (en) 1996-12-19
WO1996040098A3 true WO1996040098A3 (en) 1997-06-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/010211 WO1996040098A2 (en) 1993-05-13 1996-06-07 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues

Country Status (7)

Country Link
US (3) US6197789B1 (en)
EP (1) EP0833624B1 (en)
JP (1) JPH11510479A (en)
AT (1) ATE377418T1 (en)
AU (1) AU6277396A (en)
CA (1) CA2223595C (en)
WO (1) WO1996040098A2 (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08510209A (en) * 1993-05-13 1996-10-29 ネオルックス コーポレイション Therapeutic inhibitor of vascular smooth muscle cells
DE69435137D1 (en) * 1993-05-13 2008-10-16 Poniard Pharmaceuticals Inc PREVENTION AND TREATMENT OF PATHOLOGIES ASSOCIATED WITH AN ABNORMAL PROLIFERATION GLATTER MUSCLE CELLS
US6432982B1 (en) * 1996-02-21 2002-08-13 Eli Lilly And Company Benzothiophenes, and formulations and methods using same
AR008155A1 (en) * 1996-09-06 1999-12-09 Smithkline Beecham Corp USE OF A COMPOUND OF FORMULA I TO PREPARE A USEFUL MEDICINE TO TREAT AND PREVENT POST MENOPAUSIC CARDIOVASCULAR DISEASE IN WOMEN.
US6069175A (en) * 1996-11-15 2000-05-30 Pfizer Inc. Estrogen agonist/antagonists treatment of atherosclerosis
AU6959898A (en) 1997-04-11 1998-11-11 David J. Grainger Compounds and therapies for the prevention of vascular and non-vascular pathol ogies
US6077871A (en) * 1997-11-26 2000-06-20 Pfizer Inc. Droloxifene pharmaceutical compositions
US6623521B2 (en) 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
US20070142901A1 (en) * 1998-02-17 2007-06-21 Steinke Thomas A Expandable stent with sliding and locking radial elements
WO1999058120A1 (en) * 1998-05-08 1999-11-18 Rolf Berge USE OF NON-β-OXIDIZABLE FATTY ACID ANALOGUES FOR TREATMENT OF SYNDROME-X CONDITIONS
GB9824207D0 (en) * 1998-11-04 1998-12-30 Zeneca Ltd Neurological disorders
GB9827121D0 (en) * 1998-12-09 1999-02-03 Orion Corp Agent for lowering endothelin levels
AU2610000A (en) 1999-01-12 2000-08-01 Cambridge University Technical Services Limited Compounds and methods to inhibit or augment an inflammatory response
US6649352B1 (en) 1999-01-29 2003-11-18 Center For Molecular Medicine And Immunology Method of evaluating myelosuppressive state
US7112409B2 (en) 1999-01-29 2006-09-26 Center For Molecular Medicine And Immunology Method of determining cytokine dosage for myelosuppressive state
US7393864B2 (en) * 1999-02-26 2008-07-01 University Of Iowa Research Foundation Use of ClC3 chloride channel blockers to modulate vascular tone
US7220782B1 (en) 1999-02-26 2007-05-22 University Of Iowa Research Foundation Methods to reduce the sensitivity of endothelially-compromised vascular smooth muscle
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
JPWO2003014727A1 (en) * 2001-08-08 2004-11-25 中外製薬株式会社 Heart disease treatment
US20030032676A1 (en) * 2001-08-09 2003-02-13 Kimelberg Harold K. Drugs for treatment of cerebral injury and methods of use thereof
US6908460B2 (en) 2001-08-28 2005-06-21 Joseph Distefano Apparatus for conveying a light source to an intravenous needle to kill blood pathogens
AU2002341699A1 (en) * 2001-09-18 2003-04-01 The Johns Hopkins University Specific depletion of cd4+t cells
JP3990972B2 (en) * 2001-11-20 2007-10-17 有限会社 キック Vascular restenosis preventing agent and intravascular implant device coated with the preventing agent
US6951053B2 (en) * 2002-09-04 2005-10-04 Reva Medical, Inc. Method of manufacturing a prosthesis
CA2513086A1 (en) * 2002-12-19 2004-07-08 Scios Inc. Treatment of obesity and associated conditions with tgf-.beta. inhibitors
US7196119B2 (en) 2003-10-21 2007-03-27 The Regents Of The University Of California Development of new selective estrogen receptor modulators
US7763065B2 (en) * 2004-07-21 2010-07-27 Reva Medical, Inc. Balloon expandable crush-recoverable stent device
US20060088571A1 (en) * 2004-10-21 2006-04-27 Medtronic Vascular, Inc. Biocompatible and hemocompatible polymer compositions
US8292944B2 (en) 2004-12-17 2012-10-23 Reva Medical, Inc. Slide-and-lock stent
US7914574B2 (en) * 2005-08-02 2011-03-29 Reva Medical, Inc. Axially nested slide and lock expandable device
US9149378B2 (en) 2005-08-02 2015-10-06 Reva Medical, Inc. Axially nested slide and lock expandable device
US20070231361A1 (en) * 2006-03-28 2007-10-04 Medtronic Vascular, Inc. Use of Fatty Acids to Inhibit the Growth of Aneurysms
US7704275B2 (en) * 2007-01-26 2010-04-27 Reva Medical, Inc. Circumferentially nested expandable device
EP2211773A4 (en) 2007-11-30 2015-07-29 Reva Medical Inc Axially-radially nested expandable device
CA2737753C (en) 2008-10-10 2017-03-14 Reva Medical, Inc. Expandable slide and lock stent
KR20110039842A (en) * 2009-10-12 2011-04-20 주식회사 바이오씨에스 Composition for preventing and treating angiogenesis-related disease of eyes comprising imidazol compound as an active ingredient
GB2475907A (en) 2009-12-04 2011-06-08 Tcp Innovations Ltd Composition comprising a mixture of clopidogrel and droloxifene
US8523936B2 (en) 2010-04-10 2013-09-03 Reva Medical, Inc. Expandable slide and lock stent
KR20130100290A (en) 2010-08-30 2013-09-10 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Shear controlled release for stenotic lesions and thrombolytic therapies
KR101564059B1 (en) 2011-12-27 2015-10-30 전남대학교산학협력단 A composition for preventing or treating metabolic syndrome-related diseases
WO2014159337A1 (en) 2013-03-14 2014-10-02 Reva Medical, Inc. Reduced - profile slide and lock stent
US20160367620A1 (en) 2015-06-19 2016-12-22 Harry B. Demopoulos Glutathione
JP7100019B2 (en) * 2016-08-19 2022-07-12 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ Selective estrogen receptor modulators (SERMs) provide protection against photoreceptor degeneration

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0290012A1 (en) * 1987-05-04 1988-11-09 Oncogen TGF-B2 and novel compositions having anti-neoplastic activity
WO1992000330A1 (en) * 1990-06-25 1992-01-09 Oncogene Science, Inc. Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
WO1992008480A1 (en) * 1990-11-16 1992-05-29 Celtrix Pharmaceuticals, Inc. A β-TYPE TRANSFORMING GROWTH FACTOR
WO1994026303A1 (en) * 1993-05-13 1994-11-24 Neorx Corporation Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells

Family Cites Families (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2914563A (en) 1957-08-06 1959-11-24 Wm S Merrell Co Therapeutic composition
NL110122C (en) 1957-02-05
US3168565A (en) 1959-11-20 1965-02-02 Richardson Merrell Inc Trifluoromethyl derivatives of amino triarylethanols, -ethanes, and -ethylenes
GB1015787A (en) 1962-08-03 1966-01-05 Giuseppe Carlo Sigurta Tris-(p-methoxyphenyl)ethylene derivatives
BE637389A (en) 1962-09-13
US3288806A (en) 1964-03-23 1966-11-29 Parke Davis & Co Alpha-(aminoethoxyphenyl)-alpha-alkylstilbenes
US3634517A (en) 1968-08-19 1972-01-11 Richardson Merrell Inc Triarylalkenones
US5521171A (en) 1975-03-31 1996-05-28 Sorenson; John R. J. Anti-inflammatory and anti-ulcer compounds and process
JPS5640710B2 (en) 1973-01-18 1981-09-22
US4070484A (en) 1973-01-18 1978-01-24 Kissei Pharmaceutical Co., Ltd. Antiallergic composition containing aromatic carboxylic amide derivatives and method of using the same
US4093709A (en) 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4230862A (en) 1975-10-28 1980-10-28 Eli Lilly And Company Antifertility compounds
US4323707A (en) 1975-10-28 1982-04-06 Eli Lilly And Company Antifertility compounds
US4133814A (en) 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4235988A (en) 1976-12-13 1980-11-25 Imperial Chemical Industries Limited Delivery means for biologically active agents
US4239778A (en) 1978-09-12 1980-12-16 The University Of Illinois Foundation Azaprostanoic acid analogs and their use as inhibitors of platelet aggregation
EP0019377B1 (en) 1979-05-15 1982-08-04 Imperial Chemical Industries Plc 1-hydrocarbyloxyphenyl-1,2-diphenylalkene derivatives, their manufacture and a pharmaceutical composition containing them
US5324736A (en) 1980-03-07 1994-06-28 Research Corporation Technologies, Inc. Diphenylcyclopropyl analogs as antiestrogenic and antitumor agents
US5098903A (en) 1980-03-07 1992-03-24 Board Of Regents Of The University Of Oklahoma Diphenylcyclopropyl analogs as antiestrogenic and antitumor agents
US4879315A (en) 1982-03-30 1989-11-07 The Board Of Regents For The University Of Oklahoma Cyclopropyl analogs as anti-estrogenic, anti-tumor and female fertility agents
US5658927A (en) 1980-03-07 1997-08-19 Research Corporation Technologies Diphenylcyclopropyl analogs
US4442119A (en) 1980-07-07 1984-04-10 The Board Of Regents For The University Of Oklahoma Cyclopropyl analogs as estrogenic and anti-fertility agents
US4956129A (en) 1984-03-30 1990-09-11 Ici Americas Inc. Microencapsulation process
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
DE3046719C2 (en) 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-ene derivatives, processes for their preparation and pharmaceuticals
US4418068A (en) 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US5015666A (en) 1982-03-30 1991-05-14 Board of Reagents of the University of Oklahoma Triarylcyclopropanes as antiestrogens and antitumor agents
GB2126576B (en) 1982-06-25 1985-06-19 Farmos Group Limited Alkane and alkene derivatives
FI77839C (en) 1982-05-27 1989-05-10 Farmos Oy FOERFARANDE FOER FRAMSTAELLNING AV NYA THERAPEUTIC EFFECTIVE TRIPHENYLALKAN- OCH ALKENDERIVAT.
US5491173A (en) 1982-06-25 1996-02-13 Orion-Yhtyma Oy Tri-phenyl alkene derivatives and their preparation and use
US4512762A (en) 1982-11-23 1985-04-23 The Beth Israel Hospital Association Method of treatment of atherosclerosis and a balloon catheter for same
US5226430A (en) 1984-10-24 1993-07-13 The Beth Israel Hospital Method for angioplasty
GB8501372D0 (en) * 1985-01-18 1985-02-20 Smith Kline French Lab Chemical compounds
US5284763A (en) 1985-03-22 1994-02-08 Genentech, Inc. Nucleic acid encoding TGF-β and its uses
US4824436A (en) 1985-04-09 1989-04-25 Harvey Wolinsky Method for the prevention of restenosis
US4826672A (en) 1985-06-07 1989-05-02 President And Fellows Of Harvard College Astatinated organic compounds
DE3544663A1 (en) 1985-12-13 1987-06-19 Schering Ag THROMBOSE TREATMENT WITH FIBRINOLYTICS AND PROSTACYCLINES
US5120535A (en) 1986-11-26 1992-06-09 Oncogen Oncostatin M and novel compositions having anti-neoplastic activity
US4859585A (en) 1986-04-17 1989-08-22 Trustees Of Tufts College In-vitro methods for identifying compositions which are agonists and antagonists of estrogens
US4962091A (en) 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
US5314679A (en) 1986-07-03 1994-05-24 Advanced Magnetics Inc. Vascular magnetic resonance imaging agent comprising nanoparticles
US5216021A (en) 1986-08-28 1993-06-01 Sorenson John R J Analgesic method
EP0260066B1 (en) 1986-09-11 1990-05-09 National Research Development Corporation Tamoxifen derivatives
US5075321A (en) 1987-03-24 1991-12-24 University Of Pennsylvania Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes
ATE84806T1 (en) 1987-04-16 1993-02-15 Christian Bindschaedler METHOD OF MAKING A WATER-INSOLUBLE POLYMER POWDER THAT CAN BE REDISPERSED IN A LIQUID PHASE AND METHOD OF MAKING A DISPERSION OF THE POLYMER POWDER.
ATE80152T1 (en) 1987-04-21 1992-09-15 Heumann Pharma Gmbh & Co STABLE SOLVENT ADDUCT OF Z-1-(P-BETADIMETHYLAMINOETHOXYPHENYL)-1-(P-HYDROXYPHENYL)2-PHENYLBUT-1-EN.
US5114719A (en) 1987-04-29 1992-05-19 Sabel Bernhard A Extended drug delivery of small, water-soluble molecules
US5527337A (en) 1987-06-25 1996-06-18 Duke University Bioabsorbable stent and method of making the same
US4835002A (en) 1987-07-10 1989-05-30 Wolf Peter A Microemulsions of oil in water and alcohol
US5221620A (en) 1987-10-06 1993-06-22 Oncogen Cloning and expression of transforming growth factor β2
DE3737340A1 (en) 1987-11-04 1989-05-24 Bayer Ag NEW FLUORMETHOXYPHENYL DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS
US4929602A (en) 1987-11-25 1990-05-29 Scripps Clinic And Research Foundation Method of inhibiting platelet dependent arterial thrombosis
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
DE3821544C2 (en) 1988-06-25 1994-04-28 H Prof Dr Med Just Dilatation catheter
US5468746A (en) 1988-07-29 1995-11-21 Zambon Group S.P.A. Compounds active on the cardiovascular system
US5213580A (en) 1988-08-24 1993-05-25 Endoluminal Therapeutics, Inc. Biodegradable polymeric endoluminal sealing process
US5328471A (en) 1990-02-26 1994-07-12 Endoluminal Therapeutics, Inc. Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
SE462364B (en) 1988-09-30 1990-06-18 Goeran Hansson USING GAMMA INTERFERON FOR PREPARING A PREPARATION FOR TREATMENT OF VASCULAR STENOS
US5066789A (en) 1988-09-30 1991-11-19 Neorx Corporation Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages
US5393785A (en) 1988-10-31 1995-02-28 Endorecherche, Inc. Therapeutic antiestrogens
US5395842A (en) 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
CA2002011A1 (en) 1988-11-14 1990-05-14 Anthony F. Purchio Normal human growth regulatory receptor for tgf-beta
US5268358A (en) 1988-12-08 1993-12-07 Cor Therapeutics, Inc. PDGF receptor blocking peptides
US5380716A (en) 1988-12-15 1995-01-10 Glycomed, Inc. Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation
US5304541A (en) 1988-12-15 1994-04-19 Bristol-Myers Squibb Company Methods using novel chimeric transforming growth factor-β1/β2
US5032679A (en) 1988-12-15 1991-07-16 Glycomed, Inc. Heparin fragments as inhibitors of smooth muscle cell proliferation
US5571714A (en) 1988-12-22 1996-11-05 Celtrix Pharmaceuticals, Inc. Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use
US5284869A (en) 1991-12-17 1994-02-08 Emil Bisaccia Photophoresis methods for treating atherosclerosis and for preventing restenosis following angioplasty
US5356630A (en) 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
FR2645160B1 (en) 1989-03-31 1992-10-02 Rhone Poulenc Chimie
US5364632A (en) 1989-04-05 1994-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
US5026537A (en) 1989-04-06 1991-06-25 Centocor, Inc. Methods for imaging atherosclerotic plaque
US4994033A (en) 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5248764A (en) 1989-06-16 1993-09-28 Merck Frosst Canada, Inc. Chelate derivatives of atrial natriuretic factor (ANF)
HU212760B (en) 1989-06-20 1997-02-28 Denes Method and device for the apportion of chemical materials into the vein wall
US5242397A (en) 1989-06-20 1993-09-07 Cedars-Sinai Medical Center Catheter device and method of use for intramural delivery of protein kinase C and tyrosine protein kinase inhibitors to prevent restenosis after balloon angioplasty
DE3924538A1 (en) 1989-07-25 1991-01-31 Goedecke Ag INDOLOCARBAZOL AND THEIR USE
US4990538A (en) 1989-08-23 1991-02-05 Harris Adrian L Use of toremifene and its metabolites for the reversal of multidrug resistance of cancer cells against cytotoxic drugs
IL95500A (en) 1989-09-11 1997-03-18 Matrix Pharma ANTI-PROLIFERATIVE COMPOSITIONS CONTAINING TGF-b PROTEIN IN A VISCOUS MATRIX AND THEIR USE
US5009659A (en) 1989-10-30 1991-04-23 Schneider (Usa) Inc. Fiber tip atherectomy catheter
US5059166A (en) 1989-12-11 1991-10-22 Medical Innovative Technologies R & D Limited Partnership Intra-arterial stent with the capability to inhibit intimal hyperplasia
US5176617A (en) 1989-12-11 1993-01-05 Medical Innovative Technologies R & D Limited Partnership Use of a stent with the capability to inhibit malignant growth in a vessel such as a biliary duct
US5049132A (en) 1990-01-08 1991-09-17 Cordis Corporation Balloon catheter for delivering therapeutic agents
US5199939B1 (en) 1990-02-23 1998-08-18 Michael D Dake Radioactive catheter
US5108989A (en) 1990-04-04 1992-04-28 Genentech, Inc. Method of predisposing mammals to accelerated tissue repair
US5166143A (en) 1990-05-31 1992-11-24 E. R. Squibb & Sons, Inc. Method for preventing onset of restenosis after angioplasty employing an ace inhibitor
US5140012A (en) 1990-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Method for preventing onset of restenosis after angioplasty employing pravastatin
AU8074591A (en) 1990-06-15 1992-01-07 Cortrak Medical, Inc. Drug delivery apparatus and method
US5401730A (en) 1990-07-06 1995-03-28 The Hope Heart Institute Method for reducing platelet aggregation
US5189046A (en) 1990-08-14 1993-02-23 Nova Pharmaceutical Corporation Protein kinase C modulators
US5189212A (en) 1990-09-07 1993-02-23 University Of Georgia Research Foundation, Inc. Triarylethylene carboxylic acids with estrogenic activity
US5219548A (en) 1990-10-01 1993-06-15 Board Of Regents, The University Of Texas System High affinity halogenated-tamoxifen derivatives and uses thereof
US5238714A (en) 1990-10-02 1993-08-24 Board Of Regents, The University Of Texas System Efficient microcapsule preparation and method of use
US5180366A (en) 1990-10-10 1993-01-19 Woods W T Apparatus and method for angioplasty and for preventing re-stenosis
US5053033A (en) 1990-10-10 1991-10-01 Boston Advanced Technologies, Inc. Inhibition of restenosis by ultraviolet radiation
KR930006431B1 (en) 1990-10-11 1993-07-16 재단법인 한국화학연구소 Microcapsulation of drugs
ATE128034T1 (en) 1991-01-03 1995-10-15 Salk Inst For Biological Studi MITOTOXIN FOR THE TREATMENT OF VASCULAR DAMAGE.
US5102402A (en) 1991-01-04 1992-04-07 Medtronic, Inc. Releasable coatings on balloon catheters
US5171217A (en) 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
US5280016A (en) 1991-03-29 1994-01-18 Glycomed Incorporated Non-anticoagulant heparin derivatives
JPH04312526A (en) 1991-04-09 1992-11-04 Fujisawa Pharmaceut Co Ltd Remedy for osteopathy
US5116864A (en) 1991-04-09 1992-05-26 Indiana University Foundation Method for preventing restenosis following reconfiguration of body vessels
US5458568A (en) 1991-05-24 1995-10-17 Cortrak Medical, Inc. Porous balloon for selective dilatation and drug delivery
US5213576A (en) 1991-06-11 1993-05-25 Cordis Corporation Therapeutic porous balloon catheter
CA2070243A1 (en) 1991-06-14 1992-12-15 Akira Shiozawa Chroman derivatives
US5229495A (en) 1991-06-18 1993-07-20 Ludwig Institute For Cancer Research Substantially pure receptor like TGF-β 1 binding molecules and uses thereof
US5216126A (en) 1991-06-19 1993-06-01 Genentech, Inc. Receptor polypeptides and their production and uses
US5250561A (en) * 1991-08-08 1993-10-05 Ortho Pharmaceutical Corporation Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-COA reductase inhibitors
US5185260A (en) 1991-08-29 1993-02-09 The United States Of America As Represented By The United States Department Of Energy Method for distinguishing normal and transformed cells using G1 kinase inhibitors
AU2738392A (en) 1991-11-11 1993-05-13 Ciba-Geigy Ag Novel hybrid transforming growth factors
US5304325A (en) 1991-11-13 1994-04-19 Hemagen/Pfc Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use
US5270047A (en) 1991-11-21 1993-12-14 Kauffman Raymond F Local delivery of dipyridamole for the treatment of proliferative diseases
US5238950A (en) 1991-12-17 1993-08-24 Schering Corporation Inhibitors of platelet-derived growth factor
WO1993013660A1 (en) 1992-01-06 1993-07-22 Health Maintenance Programs, Inc. Pharmaceutically active antioxydant containing composition and the method of its use to prevent and treat restenosis following angioplasty
US5516781A (en) 1992-01-09 1996-05-14 American Home Products Corporation Method of treating restenosis with rapamycin
DK0622076T3 (en) 1992-01-17 1997-06-02 Daiichi Seiyaku Co Inhibitor of restenosis after percutaneous coronary arterioplasty
EP0621774B1 (en) 1992-01-21 1996-12-18 Sri International Improved process for preparing micronized polypeptide drugs
US5280109A (en) 1992-01-27 1994-01-18 Ludwig Institute For Cancer Research Isolated, large latent complexes of TGF-β2 and TGF-β3, and new binding protein for latent form TGF-β1, TGF-β2 and TGF-β3 LTBP-2
CA2087132A1 (en) 1992-01-31 1993-08-01 Michael S. Williams Stent capable of attachment within a body lumen
US5444164A (en) 1992-02-05 1995-08-22 Bristol-Myers Squibb Company TGF-β induced gene
US5288711A (en) 1992-04-28 1994-02-22 American Home Products Corporation Method of treating hyperproliferative vascular disease
US5283257A (en) 1992-07-10 1994-02-01 The Board Of Trustees Of The Leland Stanford Junior University Method of treating hyperproliferative vascular disease
TW366342B (en) 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
JP2617407B2 (en) 1992-09-14 1997-06-04 キッセイ薬品工業株式会社 Preventive and therapeutic agent for intimal cell hyperproliferative disease
US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6395494B1 (en) * 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US5346702A (en) 1992-12-04 1994-09-13 Sterling Winthrop Inc. Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization
US5344887A (en) 1992-12-21 1994-09-06 Shell Oil Company Star polymers of dienes, vinylarenes and alkyl methacrylates as modiied viscosity index improvers
TW383306B (en) * 1992-12-22 2000-03-01 Lilly Co Eli New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol
GB2273873A (en) 1992-12-23 1994-07-06 Univ Sheffield Treatment of psoriasis
US5354774A (en) 1992-12-24 1994-10-11 Yale University Inhibition of smooth muscle cell proliferation by 8-methoxypsoralen photoactivated by visible light
US5429634A (en) 1993-09-09 1995-07-04 Pdt Systems Biogenic implant for drug delivery and method
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
DE4401554A1 (en) 1993-02-16 1994-08-18 Freund Andreas Product for the therapy and prophylaxis of disorders occurring in plasma lipid inbalance
US5308862A (en) 1993-03-05 1994-05-03 Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beecham Corp., Ltd. Partnership No. 1 Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation
US5482949A (en) 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US5445941A (en) * 1993-06-21 1995-08-29 Eli Lilly And Company Method for screening anti-osteoporosis agents
EP0635264B1 (en) * 1993-06-24 1997-09-10 Eli Lilly And Company Antiestrogenic 2-phenyl-3-aroylbenzothiophenes as hypoglycemic agents
DE4320898A1 (en) 1993-06-24 1995-01-05 Denecke Rainer Dr Med Vet Product for the therapy and prophylaxis of disorders occurring in cases of plasma lipid imbalance
DE4320896A1 (en) 1993-06-24 1995-01-05 Denecke Rainer Dr Med Vet Product for the therapy and prophylaxis of dementias
TW303299B (en) 1993-07-22 1997-04-21 Lilly Co Eli
US5354801A (en) 1993-08-12 1994-10-11 Cytec Technology Corp. Process for producing small polymer phase droplet microemulsions by multistep aqueous phase addition
US5441947A (en) 1993-08-25 1995-08-15 Eli Lilly And Company Methods of inhibiting vascular restenosis
US5418252A (en) 1993-10-15 1995-05-23 Eli Lilly And Company Method for inhibiting cartilage degradation
US5441964A (en) 1993-10-15 1995-08-15 Eli Lilly And Company Methods for inhibiting bone loss using substituted benzothiophene
US5482950A (en) 1993-10-15 1996-01-09 Eli Lilly And Company Methods for lowering serum cholesterol
US5457113A (en) 1993-10-15 1995-10-10 Eli Lilly And Company Methods for inhibiting vascular smooth muscle cell proliferation and restinosis
US5457116A (en) 1993-10-15 1995-10-10 Eli Lilly And Company Methods of inhibiting uterine fibrosis
CN1058390C (en) 1993-10-15 2000-11-15 伊莱利利公司 Methods for exhibiting angiogenisis and angiogenic diseases
US5391557A (en) 1993-10-15 1995-02-21 Eli Lilly And Company Methods for the treatment of peri-menopausal syndrome
US5480904A (en) 1993-10-28 1996-01-02 Eli Lilly And Company Methods for inhibiting uterine fibrosis
US5436243A (en) 1993-11-17 1995-07-25 Research Triangle Institute Duke University Aminoanthraquinone derivatives to combat multidrug resistance
US5393772A (en) 1993-11-24 1995-02-28 Boehringer Mannheim Pharmaceuticals Corporation Use of, and method of treatment using, hydroxycarbazole compounds for inhibition of smooth muscle migration and proliferation
US5492927A (en) 1993-12-21 1996-02-20 Eli Lilly And Company Non-peptide tachykinin receptor antagonists to treat allergy
US5552415A (en) 1993-12-21 1996-09-03 Eli Lilly And Company Method of inhibiting Alzheimer's Disease
US5447941A (en) 1993-12-21 1995-09-05 Eli Lilly And Company Methods of inhibiting pulmonary hypertensive diseases with raloxifene and related benzothiophenes
US5441965A (en) 1993-12-21 1995-08-15 Eli Lilly And Company Methods of inhibiting thrombin
US5574047A (en) 1993-12-21 1996-11-12 Eli Lilly And Company Methods of inhibiting imperfect tissue repair
US5446053A (en) 1993-12-21 1995-08-29 Eli Lilly And Company Methods of inhibiting dysfunctional uterine bleeding
US5521198A (en) 1993-12-21 1996-05-28 Eli Lilly And Company Methods of inhibiting autoimmune diseases
ATE260104T1 (en) 1993-12-21 2004-03-15 Lilly Co Eli INHIBITION OF ADVANCED GLYCOLIZATION END PRODUCTS
US5439923A (en) 1993-12-21 1995-08-08 Eli Lilly And Company Method of inhibiting seborrhea and acne
US5439931A (en) 1993-12-21 1995-08-08 Eli Lilly And Company Method for increasing libido in post-menopausal women
US5389670A (en) 1993-12-21 1995-02-14 Eli Lilly Company Methods of inhibiting the symptoms of premenstrual syndrome/late luteal phase dysphoric disorder
US5519042A (en) 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
US5407955A (en) 1994-02-18 1995-04-18 Eli Lilly And Company Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease
ZA951497B (en) 1994-03-02 1996-08-23 Lilly Co Eli Orally administerable pharmaceutical formulations
US5478847A (en) 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
US5681835A (en) 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
US5426123A (en) 1994-05-11 1995-06-20 Eli Lilly And Company Method for lowering serum cholesterol with 1,1,2-triphenylbut-1-ene derivatives
US5384332A (en) 1994-05-11 1995-01-24 Eli Lilly And Company Methods for inhibiting aortal smooth muscle cell proliferation and restenosis with 1,1,2-triphenylbut-1-ene derivatives
US5455275A (en) 1994-05-11 1995-10-03 Eli Lilly And Company Methods for inhibiting endometriosis and uterine fibroid disease with 1,1,2-triphenylbut-1-ene derivatives
US5470883A (en) 1994-05-23 1995-11-28 Stromberg; Brent V. Method of treating peripheral vasoconstriction with tamoxifen citrate
US5424331A (en) 1994-06-10 1995-06-13 Bio-Virus Research Incorporated Pharmaceutical compositions and dietary soybean food products for the prevention of osteoporosis
US5466810A (en) 1994-06-10 1995-11-14 Eli Lilly And Company 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes
US5441986A (en) 1994-07-19 1995-08-15 Pfizer Inc. Estrogen agonists as remedies for prostate and cardiovascular diseases
US5496828A (en) * 1994-08-22 1996-03-05 Eli Lilly And Company Methods of inhibiting ulcerative mucositis
US5434166A (en) 1994-08-22 1995-07-18 Eli Lilly And Company Methods of inhibiting demyelinating and desmyelinating diseases
US5491159A (en) 1994-08-30 1996-02-13 American Home Products Corporation 2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-oxazoles as anti-atherosclerotic agents
US7501441B1 (en) 1994-09-20 2009-03-10 Eli Lilly And Company Naphthyl compounds, intermediates, processes, compositions, and methods
US5484798A (en) 1994-09-20 1996-01-16 Eli Lilly And Company Benzothiopene compounds, compositions, and method of inhibiting restenosis
US5521191A (en) 1994-10-17 1996-05-28 Washington University Method for treatment of arterial stenosis
US5516807A (en) 1994-10-25 1996-05-14 Warner-Lambert Company Method for treating vascular proliferative disorders following balloon angioplasty
US5498775A (en) 1994-11-07 1996-03-12 American Home Products Corporation Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation
US5489587A (en) 1995-01-20 1996-02-06 Eli Lilly And Company Benzofurans used to inhibit bone loss
US5484808A (en) 1995-02-09 1996-01-16 Eli Lilly And Company Methods of inhibiting cell-cell adhesion
US5510357A (en) 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
US5563054A (en) 1995-03-31 1996-10-08 Eli Lilly And Company Process for preparation of benzo[B]thiophene glucuronides
US5622975A (en) 1995-06-01 1997-04-22 Eli Lilly And Company Methods for inhibiting vascular smooth muscle cell migration
US5639274A (en) 1995-06-02 1997-06-17 Fischell; Robert E. Integrated catheter system for balloon angioplasty and stent delivery
US5726186A (en) 1995-09-08 1998-03-10 Eli Lilly And Company Pentacyclic compounds, intermediates, processes, compositions, and methods
AU6959898A (en) * 1997-04-11 1998-11-11 David J. Grainger Compounds and therapies for the prevention of vascular and non-vascular pathol ogies

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0290012A1 (en) * 1987-05-04 1988-11-09 Oncogen TGF-B2 and novel compositions having anti-neoplastic activity
WO1992000330A1 (en) * 1990-06-25 1992-01-09 Oncogene Science, Inc. Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
WO1992008480A1 (en) * 1990-11-16 1992-05-29 Celtrix Pharmaceuticals, Inc. A β-TYPE TRANSFORMING GROWTH FACTOR
WO1994026303A1 (en) * 1993-05-13 1994-11-24 Neorx Corporation Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A.A. COLLETTA ET AL.: "Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts.", BR. J. CANCER, vol. 62, no. 3, 1990, pages 405 - 409, XP002017503 *
D.J. GRAINGER ET AL.: "Tamoxifen: teaching an old drug new tricks?", NATURE MEDICINE, vol. 2, no. 4, 1996, pages 381 - 385, XP000604987 *
G.K. OWENS ET AL.: "Transforming growth factor beta-induced growth inhibition and cellular hypertrophy in cultured vascular smooth muscle cells.", J. CELL BIOL., vol. 107, no. 2, 1988, pages 771 - 780, XP000605661 *
H. YOUNG ET AL.: "Pharmacokinetics and biodistribution of radiolabelled idoxifene: prospects for the use of PET in the evaluation of a novel antioestrogen for cancer therapy.", NUCL. MED. BIOL., vol. 22, no. 4, 1995, pages 405 - 411, XP000604994 *
R.A. MAJACK ET AL.: "Role of PDGF-A expression in the control of vascular smooth muscle cell growth by Transforming Growth Factor beta.", J. CELL BIOL., vol. 111, no. 1, 1990, pages 239 - 247, XP000605659 *

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