WO1996040087A3 - Pressure sensitive acrylate adhesive composition cross-linked with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group - Google Patents

Pressure sensitive acrylate adhesive composition cross-linked with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group Download PDF

Info

Publication number
WO1996040087A3
WO1996040087A3 PCT/US1996/008492 US9608492W WO9640087A3 WO 1996040087 A3 WO1996040087 A3 WO 1996040087A3 US 9608492 W US9608492 W US 9608492W WO 9640087 A3 WO9640087 A3 WO 9640087A3
Authority
WO
WIPO (PCT)
Prior art keywords
pressure sensitive
linked
hydroxyl group
drug
sensitive acrylate
Prior art date
Application number
PCT/US1996/008492
Other languages
French (fr)
Other versions
WO1996040087A2 (en
Inventor
Chunhua Li
Edward Schonfeld
Tara Chu
Chia-Ming Chiang
Original Assignee
Cygnus Therapeutic Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cygnus Therapeutic Systems filed Critical Cygnus Therapeutic Systems
Priority to AU60326/96A priority Critical patent/AU6032696A/en
Publication of WO1996040087A2 publication Critical patent/WO1996040087A2/en
Publication of WO1996040087A3 publication Critical patent/WO1996040087A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates

Abstract

Non-yellowing organic solvent based pressure sensitive acrylate adhesives that have good cohesive strength and cold flow properties and are useful in fabricating transdermal drug delivery patches are made from an organic solvent based pressure sensitive acrylate adhesive cross-linked with aluminum acetylacetonate and combined with a drug, such as estradiol, that has a reactive aromatic hydroxyl group.
PCT/US1996/008492 1995-06-07 1996-06-03 Pressure sensitive acrylate adhesive composition cross-linked with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group WO1996040087A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU60326/96A AU6032696A (en) 1995-06-07 1996-06-03 Pressure sensitive acrylate adhesive composition cross-linke d with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48429495A 1995-06-07 1995-06-07
US08/484,294 1995-06-07

Publications (2)

Publication Number Publication Date
WO1996040087A2 WO1996040087A2 (en) 1996-12-19
WO1996040087A3 true WO1996040087A3 (en) 1997-01-30

Family

ID=23923554

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/008492 WO1996040087A2 (en) 1995-06-07 1996-06-03 Pressure sensitive acrylate adhesive composition cross-linked with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group

Country Status (2)

Country Link
AU (1) AU6032696A (en)
WO (1) WO1996040087A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9186335B2 (en) 2002-07-30 2015-11-17 Ucb Pharma Gmbh Hot melt TTS for administering rotigotine

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3534775B2 (en) * 1995-06-07 2004-06-07 オーソ―マクニール ファーマシューティカル，インコーポレイテッド Transdermal patches and methods for administering 17-deacetylnorgestimate alone or in combination with estrogens
DE19706824C1 (en) * 1997-02-21 1998-03-26 Lohmann Therapie Syst Lts Plaster for transdermal drug delivery
DE19814084B4 (en) 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2 agonist-containing transdermal therapeutic system for the treatment of Parkinson's syndrome and process for its preparation
DE10000333A1 (en) * 2000-01-07 2001-07-19 Lohmann Therapie Syst Lts Pharmaceutical composition for the transdermal administration of hormones with a permeation-improving additive
EP1311559B1 (en) * 2000-06-01 2006-08-02 Kraton Polymers Research B.V. Compositions comprising a functionalized block copolymer crosslinked with aluminum acetylacetonate
DE10157745A1 (en) * 2001-11-24 2003-06-26 Hf Arzneimittelforsch Gmbh Transdermal therapeutic system for the administration of 17alpha-estradiol
US6653408B1 (en) 2002-11-21 2003-11-25 Kraton Polymers U.S. Llc Compositions comprising a functionalized block copolymer crosslinked with aluminum acetylacetonate
US7816546B2 (en) 2003-06-30 2010-10-19 Richter Gedeon Vegyeszeti Gyar Rt. Process for the synthesis of high purity d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime
DE10333393A1 (en) * 2003-07-23 2005-02-24 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system with the active ingredient pramipexole
CN106572981B (en) 2014-07-04 2020-03-03 绿叶制药股份公司 Apparatus for manufacturing drug patch
US11541018B2 (en) 2016-06-23 2023-01-03 Corium, Llc Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
US20180028461A1 (en) 2016-07-27 2018-02-01 Corium International, Inc. Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
JP7071958B2 (en) 2016-07-27 2022-05-19 コリウム， インコーポレイテッド Memantine transdermal delivery system
CA3031945A1 (en) 2016-07-27 2018-02-01 Corium International, Inc. Transdermal formulation and delivery method of low solubility or unstable unionized neutral drugs by in situ salt-to-neutral drug conversion of salt drug
CA3086163A1 (en) 2017-12-20 2019-06-27 Corium, Inc. Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0435200A2 (en) * 1989-12-28 1991-07-03 Nitto Denko Corporation Estrogen-containing gel preparation
US5204109A (en) * 1989-12-28 1993-04-20 Nitto Denko Corporation Percutaneous gel preparation
US5240711A (en) * 1989-11-29 1993-08-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system comprising as active component buprenorphine
US5298258A (en) * 1989-12-28 1994-03-29 Nitto Denko Corporation Acrylic oily gel bioadhesive material and acrylic oily gel preparation
US5306503A (en) * 1990-06-25 1994-04-26 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Patch with a high content of softening ingredients

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240711A (en) * 1989-11-29 1993-08-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system comprising as active component buprenorphine
EP0435200A2 (en) * 1989-12-28 1991-07-03 Nitto Denko Corporation Estrogen-containing gel preparation
US5204109A (en) * 1989-12-28 1993-04-20 Nitto Denko Corporation Percutaneous gel preparation
US5298258A (en) * 1989-12-28 1994-03-29 Nitto Denko Corporation Acrylic oily gel bioadhesive material and acrylic oily gel preparation
US5306503A (en) * 1990-06-25 1994-04-26 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Patch with a high content of softening ingredients

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9186335B2 (en) 2002-07-30 2015-11-17 Ucb Pharma Gmbh Hot melt TTS for administering rotigotine

Also Published As

Publication number Publication date
AU6032696A (en) 1996-12-30
WO1996040087A2 (en) 1996-12-19

Similar Documents

Publication Publication Date Title
WO1996040087A3 (en) Pressure sensitive acrylate adhesive composition cross-linked with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group
CA2259532A1 (en) Transdermal drug delivery matrix for coadministering estradiol and another steroid
CN101842065B (en) Transdermal delivery system comprising a coated release liner
TW200621926A (en) Pressure-sensitive adhesive sheet
IL144617A0 (en) Adhesives
EP0479223B1 (en) Transfer sheet
WO1999055286A3 (en) Drug-containing transdermal patches, plastisols and adhesives
WO1996008229A3 (en) Matrix for transdermal drug delivery
WO2000041538A3 (en) Dermal compositions
WO2005048228A3 (en) Electro-optic displays
AU2001288536A1 (en) Cross-linked foamed pressure sensitive adhesive and method for preparing the same
EP0232055A3 (en) Thermally stable hot melt moisture curing polyurethane adhesive composition
AU3593597A (en) Medical adhesive bandage, delivery system and method
CN101326253A (en) Acrylate adhesive with water-resistant bonding properties
EP0995778A3 (en) Coating composition with improved intercoat adhesion
CA2243741A1 (en) High shear pipeline tape
CA2146480A1 (en) Coating compositions containing 1,4-cyclohexane dimethanol
AU3632995A (en) Multilayer adhesive construction with one barrier layer
ES2178824T3 (en) ADHESIVE SYSTEMS FOR A STICKER BINDING PROCEDURE OF ONE OR SEVERAL STAGES, PROCEDURE FOR THE DOCUMENT SIDED BINDING.
CA2446132A1 (en) Primer/membrane barrier system
WO1998036740A3 (en) Transdermal or topical plaster system with a polyacrylate matrix with improved physical properties
EP1090972A3 (en) Solvent-free two-component curable adhesive composition
US20020015828A1 (en) Transfer label
WO1991000583A3 (en) Die-cuttable and dispensable deformable labels
NO955280L (en) Polyamide powder blend for coating metal substrates

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LU LV MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML

AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LU LV MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA