WO1996040081A3 - Oral delivery of gene constructs - Google Patents

Oral delivery of gene constructs Download PDF

Info

Publication number
WO1996040081A3
WO1996040081A3 PCT/US1996/009371 US9609371W WO9640081A3 WO 1996040081 A3 WO1996040081 A3 WO 1996040081A3 US 9609371 W US9609371 W US 9609371W WO 9640081 A3 WO9640081 A3 WO 9640081A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
oral delivery
gene constructs
gene construct
target site
Prior art date
Application number
PCT/US1996/009371
Other languages
French (fr)
Other versions
WO1996040081A2 (en
Inventor
Peter E Daddona
Chadarevian Gamil G De
Joseph A Fix
Phyllis I Gardner
Howard B Rosen
Original Assignee
Alza Corp
Peter E Daddona
Chadarevian Gamil G De
Joseph A Fix
Phyllis I Gardner
Howard B Rosen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp, Peter E Daddona, Chadarevian Gamil G De, Joseph A Fix, Phyllis I Gardner, Howard B Rosen filed Critical Alza Corp
Priority to AU60978/96A priority Critical patent/AU6097896A/en
Priority to JP9501704A priority patent/JPH11507340A/en
Priority to EP96918287A priority patent/EP0831771A2/en
Publication of WO1996040081A2 publication Critical patent/WO1996040081A2/en
Publication of WO1996040081A3 publication Critical patent/WO1996040081A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

The present invention is a method for the delivery of a gene construct to a targeted portion in the gastrointestinal tract. Delivery of the gene construct occurs as a bolus dose that will cause the expression of a therapeutically effective amount of a therapeutic protein at the target site. The invention is also directed to a device for delivery of the gene construct at the target site.
PCT/US1996/009371 1995-06-07 1996-06-07 Oral delivery of gene constructs WO1996040081A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU60978/96A AU6097896A (en) 1995-06-07 1996-06-07 Oral delivery of gene constructs
JP9501704A JPH11507340A (en) 1995-06-07 1996-06-07 Oral delivery of gene constructs
EP96918287A EP0831771A2 (en) 1995-06-07 1996-06-07 Oral delivery of gene constructs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47596195A 1995-06-07 1995-06-07
US08/475,961 1995-06-07

Publications (2)

Publication Number Publication Date
WO1996040081A2 WO1996040081A2 (en) 1996-12-19
WO1996040081A3 true WO1996040081A3 (en) 1997-02-20

Family

ID=23889916

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/009371 WO1996040081A2 (en) 1995-06-07 1996-06-07 Oral delivery of gene constructs

Country Status (6)

Country Link
EP (1) EP0831771A2 (en)
JP (1) JPH11507340A (en)
KR (1) KR19990022184A (en)
AU (1) AU6097896A (en)
CA (1) CA2221323A1 (en)
WO (1) WO1996040081A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691785B2 (en) 1997-07-01 2014-04-08 Isis Pharmaceuticals, Inc. Compositions and methods for non-parenteral delivery of oligonucleotides

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976571A (en) * 1991-01-31 1999-11-02 Port Systems, L.L.C. Method for making a multi-stage drug delivery system
IL122349A0 (en) * 1995-06-07 1998-04-05 Univ Yale Adeno-associated viral vectors
US6225290B1 (en) 1996-09-19 2001-05-01 The Regents Of The University Of California Systemic gene therapy by intestinal cell transformation
JP2002508530A (en) * 1997-12-12 2002-03-19 シュノプティク アクティーゼルスカブ Container for the timely release of substances
WO2000035494A1 (en) * 1998-12-14 2000-06-22 Synoptik Holding A/S A system for cleaning contact lenses
WO2002089855A1 (en) * 2001-04-27 2002-11-14 Auckland Uniservices Limited Peroral transduction of hepatocytes in the treatment of disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003769A1 (en) * 1991-08-20 1993-03-04 THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTEMENT OF HEALTH AND HUMAN SERVICES Adenovirus mediated transfer of genes to the gastrointestinal tract
WO1993019660A1 (en) * 1992-04-03 1993-10-14 Baylor College Of Medicine Gene therapy using the intestine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003769A1 (en) * 1991-08-20 1993-03-04 THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTEMENT OF HEALTH AND HUMAN SERVICES Adenovirus mediated transfer of genes to the gastrointestinal tract
WO1993019660A1 (en) * 1992-04-03 1993-10-14 Baylor College Of Medicine Gene therapy using the intestine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691785B2 (en) 1997-07-01 2014-04-08 Isis Pharmaceuticals, Inc. Compositions and methods for non-parenteral delivery of oligonucleotides

Also Published As

Publication number Publication date
WO1996040081A2 (en) 1996-12-19
KR19990022184A (en) 1999-03-25
CA2221323A1 (en) 1996-12-19
AU6097896A (en) 1996-12-30
JPH11507340A (en) 1999-06-29
EP0831771A2 (en) 1998-04-01

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