WO1996040042A3 - Stabilized steroid compositions - Google Patents

Stabilized steroid compositions Download PDF

Info

Publication number
WO1996040042A3
WO1996040042A3 PCT/US1996/009651 US9609651W WO9640042A3 WO 1996040042 A3 WO1996040042 A3 WO 1996040042A3 US 9609651 W US9609651 W US 9609651W WO 9640042 A3 WO9640042 A3 WO 9640042A3
Authority
WO
WIPO (PCT)
Prior art keywords
metal
degradation
conditions
steroid compositions
stabilized
Prior art date
Application number
PCT/US1996/009651
Other languages
French (fr)
Other versions
WO1996040042A2 (en
Inventor
Chong Min Won
Christianna L Strohbeck
Sheng-Yuh Tang
Bih-Hsiung Hsu
Original Assignee
Rhone Poulenc Rorer Pharma
Chong Min Won
Christianna L Strohbeck
Tang Sheng Yuh
Hsu Bih Hsiung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Pharma, Chong Min Won, Christianna L Strohbeck, Tang Sheng Yuh, Hsu Bih Hsiung filed Critical Rhone Poulenc Rorer Pharma
Priority to JP9501925A priority Critical patent/JPH11507359A/en
Priority to EP96919250A priority patent/EP0843548A4/en
Priority to AU61641/96A priority patent/AU6164196A/en
Priority to BR9608721-8A priority patent/BR9608721A/en
Publication of WO1996040042A2 publication Critical patent/WO1996040042A2/en
Publication of WO1996040042A3 publication Critical patent/WO1996040042A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Abstract

The degradation of triamcinolone acetonide in aqueous solutions is studied under accelerated storage conditions of 70 °C over the pH range 1-10. Trace level metal ions can markedly accelerate the oxidative degradation in neutral and basic solutions, but pH conditions and/or the inclusion of metal-sequestering agents, such as ethylenediamine tetra acetate (EDTA), in a preparation depresses the metal catalysis.
PCT/US1996/009651 1995-06-07 1996-06-05 Stabilized steroid compositions WO1996040042A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP9501925A JPH11507359A (en) 1995-06-07 1996-06-05 Stabilized steroid composition
EP96919250A EP0843548A4 (en) 1995-06-07 1996-06-05 Stabilized steroid compositions
AU61641/96A AU6164196A (en) 1995-06-07 1996-06-05 Stabilized steroid compositions
BR9608721-8A BR9608721A (en) 1995-06-07 1996-06-05 Pharmaceutical composition and process for treating inflammation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48533995A 1995-06-07 1995-06-07
US08/485,339 1995-06-07

Publications (2)

Publication Number Publication Date
WO1996040042A2 WO1996040042A2 (en) 1996-12-19
WO1996040042A3 true WO1996040042A3 (en) 1997-02-06

Family

ID=23927770

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/009651 WO1996040042A2 (en) 1995-06-07 1996-06-05 Stabilized steroid compositions

Country Status (6)

Country Link
EP (1) EP0843548A4 (en)
JP (1) JPH11507359A (en)
AU (1) AU6164196A (en)
BR (1) BR9608721A (en)
CA (1) CA2223385A1 (en)
WO (1) WO1996040042A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6315985B1 (en) 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
JP5259193B2 (en) * 2005-02-25 2013-08-07 チエシイ・ファルマセウテイシイ・エス・ペー・アー Medicinal aerosol formulations containing sequestering agents for dose-measuring inhalers under pressure
MX2009006613A (en) 2006-12-21 2009-07-02 Nerviano Medical Sciences Srl Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors.
EP3456314A1 (en) 2017-09-14 2019-03-20 Tiofarma B.V. Topical formulation comprising 17-ketolic corticosteroid

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364617A (en) * 1990-04-26 1994-11-15 The Procter & Gamble Company Chelator compositions comprising oxime compounds
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4344940A (en) * 1981-11-30 1982-08-17 E. R. Squibb & Sons, Inc. Steroid formulation containing dipotassium EDTA
KR950000032A (en) * 1993-06-09 1995-01-03 류경열 How to make sesame oil

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5364617A (en) * 1990-04-26 1994-11-15 The Procter & Gamble Company Chelator compositions comprising oxime compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0843548A4 *

Also Published As

Publication number Publication date
EP0843548A4 (en) 1998-10-28
WO1996040042A2 (en) 1996-12-19
CA2223385A1 (en) 1996-12-19
JPH11507359A (en) 1999-06-29
BR9608721A (en) 1999-10-13
MX9709431A (en) 1998-10-31
AU6164196A (en) 1996-12-30
EP0843548A2 (en) 1998-05-27

Similar Documents

Publication Publication Date Title
NZ504423A (en) Composition having enhanced penetration capabilities and irritation reducing systems
AU2550895A (en) Room temperature sterilant
CA2180648A1 (en) Aqueous topical anti-acne compositions of low ph
CA2011171A1 (en) Biodegradable Poly (Phosphate Esters)
EP0806201A3 (en) Foamable cosmetic mask product
CA2229271A1 (en) Compositions containing hydroxy acids or retinoids
AU3598793A (en) Aqueous stripping composition containing a peroxide and butyrolactone, ethylene carbonate or a water soluble ester
CA2164050A1 (en) Cosmetic compositions containing betulinic acid
NZ329184A (en) Delivery device for mixing and/or topically applying two compositions, one containing an active compound and the other containing a skin permeation enhancer
WO2000015179A3 (en) Cosmetic composition
CA2212850A1 (en) Borage seed oil as an anti-irritant in compositions containing hydroxy acids or retinoids
ES8608876A1 (en) Improved penetrating topical pharmaceutical compositions containing corticosteroids.
AU2941900A (en) Biodegradable cellulose acetate constructions and tobacco filter
CA2139381A1 (en) Guar as drift control agent
NZ333357A (en) Reduction of cardiotoxicity of an antitumor agent using manganese compound
AU2922797A (en) Novel steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
IE810500L (en) Hair conditioning composition
CA2205943A1 (en) Corrosion inhibitor
WO1996040042A3 (en) Stabilized steroid compositions
EP0260869A3 (en) Deodorant composition
MX9800194A (en) Nonaqueous detergent compositions comprising effervescent systems.
EP0914828A3 (en) Use of des-aspartate-angiotensin I
CA2432534A1 (en) Gel composition and trans-scrotal application of a composition for the treatment of hypogonadism
CA2165494A1 (en) Composition and method for inhibiting coal oxidation
CA2178605A1 (en) Pharmaceutical formulation for preventing or pre-treating poisoning by organophosphoric cholinesterase inhibitors

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML

AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref country code: JP

Ref document number: 1997 501925

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: PA/a/1997/009431

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 2223385

Country of ref document: CA

Ref country code: CA

Ref document number: 2223385

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1996919250

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1996919250

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1996919250

Country of ref document: EP