WO1996038093A3 - Method for laser mediated tissue welding with enhanced strength - Google Patents

Method for laser mediated tissue welding with enhanced strength Download PDF

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Publication number
WO1996038093A3
WO1996038093A3 PCT/US1996/008458 US9608458W WO9638093A3 WO 1996038093 A3 WO1996038093 A3 WO 1996038093A3 US 9608458 W US9608458 W US 9608458W WO 9638093 A3 WO9638093 A3 WO 9638093A3
Authority
WO
WIPO (PCT)
Prior art keywords
concentration
solder
solders
incorporation
growth factors
Prior art date
Application number
PCT/US1996/008458
Other languages
French (fr)
Other versions
WO1996038093A2 (en
Inventor
Dix P Poppas
Gerard Marx
Original Assignee
Childrens Medical Center
Melville Biolog Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center, Melville Biolog Inc filed Critical Childrens Medical Center
Priority to IL12232896A priority Critical patent/IL122328A0/en
Priority to JP8536773A priority patent/JPH11504835A/en
Priority to AU59715/96A priority patent/AU5971596A/en
Priority to EP96917016A priority patent/EP0830087A2/en
Publication of WO1996038093A2 publication Critical patent/WO1996038093A2/en
Publication of WO1996038093A3 publication Critical patent/WO1996038093A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00513—Tissue soldering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00513—Tissue soldering
    • A61B2017/00517—Tissue soldering using laser

Abstract

Methods for tissue welding using solders incorporating biologically active agents, such as growth factors or hemostatic agents, have been developed. Improved solder compositions have also been defined, yielding greater bursting strength as a function of protein concentration, and through the use of protein unfolding prior to laser-mediated denaturation and coupling. A method for repair of fistulas has been discovered, using water as a chromophore, in combination with solder concentration, to form columns to fill defects where tissue apposition is not possible. Methods have also been adapted for use with other forms of directed energy, including bipolar electrosurgery and light. Examples demonstrate increased strength of repairs by incorporation of growth factors into solders, alone and as a function of solder concentration. Increased adhesion is obtained through prevention of bleeding by incorporation of hemostatic agents such as thrombin or epinephrine, a vasoconstrictor.
PCT/US1996/008458 1995-06-02 1996-06-03 Method for laser mediated tissue welding with enhanced strength WO1996038093A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IL12232896A IL122328A0 (en) 1995-06-02 1996-06-03 Method for laser mediated tissue welding with enhanced strength
JP8536773A JPH11504835A (en) 1995-06-02 1996-06-03 Method for laser-mediated tissue joining with enhanced strength
AU59715/96A AU5971596A (en) 1995-06-02 1996-06-03 Method for laser mediated tissue welding with enhanced strength
EP96917016A EP0830087A2 (en) 1995-06-02 1996-06-03 Method for laser mediated tissue welding with enhanced strength

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US458,885 1983-01-18
US08/458,885 US5713891A (en) 1995-06-02 1995-06-02 Modified solder for delivery of bioactive substances and methods of use thereof

Publications (2)

Publication Number Publication Date
WO1996038093A2 WO1996038093A2 (en) 1996-12-05
WO1996038093A3 true WO1996038093A3 (en) 1997-03-06

Family

ID=23822479

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/008458 WO1996038093A2 (en) 1995-06-02 1996-06-03 Method for laser mediated tissue welding with enhanced strength

Country Status (7)

Country Link
US (1) US5713891A (en)
EP (1) EP0830087A2 (en)
JP (1) JPH11504835A (en)
AU (1) AU5971596A (en)
CA (1) CA2222633A1 (en)
IL (1) IL122328A0 (en)
WO (1) WO1996038093A2 (en)

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Also Published As

Publication number Publication date
CA2222633A1 (en) 1996-12-05
WO1996038093A2 (en) 1996-12-05
EP0830087A2 (en) 1998-03-25
JPH11504835A (en) 1999-05-11
IL122328A0 (en) 1998-04-05
AU5971596A (en) 1996-12-18
US5713891A (en) 1998-02-03

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