WO1996024075A1 - Crosslinked polymers containing ester or amide groups - Google Patents
Crosslinked polymers containing ester or amide groups Download PDFInfo
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- WO1996024075A1 WO1996024075A1 PCT/EP1996/000246 EP9600246W WO9624075A1 WO 1996024075 A1 WO1996024075 A1 WO 1996024075A1 EP 9600246 W EP9600246 W EP 9600246W WO 9624075 A1 WO9624075 A1 WO 9624075A1
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- 0 COCC(*)(*N*)OC Chemical compound COCC(*)(*N*)OC 0.000 description 1
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
Definitions
- the invention relates to a novel process for the production of mouldings, in particular contact lenses, in which a water-soluble, crosslinkable polymer containing, in particular ester-linked or amide-linked crosslinkable acrylate groups is crosslinked, preferably in aqueous solution, and to mouldings, in particular contact lenses, which are obtainable by this process.
- the present invention also relates to novel water-soluble, crosslinkable polymers which can be employed in the novel process, in particular those based on starting polymers containing functional groups, for example hydroxyl groups, on the polymer chain or functional groups, for example imino groups, in the polymer chain or functional groups bonded to the polymer skeleton via a bridge, where these functional groups allow covalent bonds to compounds containing a crosslinkable modifier group or another modifier group.
- These starting polymers are, in particular, polyhydroxyl compounds having a 1,2- and/or 1,3-diol structure, such as polyvinyl alcohol, or hydrolysed copolymers of vinyl acetate, for example copolymers with vinyl chloride, N-vinylpyrrolidone, etc.
- the invention furthermore relates to crosslinked polymers, either homopolymers or copolymers, made from these novel water-soluble, crosslinkable polymers, to a process for the preparation of the novel water-soluble, crosslinkable polymers and the homopolymers and copolymers obtainable therefrom, to mouldings made from said homopolymers or copolymers, in particular contact lenses made from these homopolymers or copolymers, and to a process for the production of contact lenses using the said homopolymers or copolymers.
- EP 216074 discloses contact lenses comprising polyvinyl alcohol containing (meth)acryloyl groups bonded via urethane groups.
- EP 189 375 describes contact lenses comprising polyvinyl alcohol crosslinked by means of polyepoxides.
- EP 201 693 describes, inter alia, acetals of unbranched aldehydes having 2 to 11 carbon atoms carrying a terminal amino group which is substituted by a C 3 -C 24 ⁇ lefinically unsaturated organic radical.
- This organic radical contains a functionality which withdraws electrons from the nitrogen atom, and furthermore the olefinically unsaturated functionality is polymerizable.
- EP 201 693 also claims products of the reaction of the acetals characterized above with a 1,2-diol, a 1 ,3-diol, a polyvinyl alcohol or a cellulose. However, such products are not described directly.
- the present invention relates to water-soluble, crosslinkable polymers which are based on a starting polymer (polymer backbone) which has a functional group which is capable of reacting with an azalactone with ring opening, such as, in particular, an alcoholic hydroxyl group or an amino group, and which preferably have a 1,3-diol, 1,3-amine, 1,3-imine or 1,4-imine skeleton, a certain percentage of these skeleton units being modified to form an ester or amide containing a crosslinkable (alkyl)acrylic acid radical.
- a starting polymer polymer backbone
- a functional group which is capable of reacting with an azalactone with ring opening, such as, in particular, an alcoholic hydroxyl group or an amino group
- an azalactone with ring opening such as, in particular, an alcoholic hydroxyl group or an amino group
- the novel crosslinkable, water-soluble polymer is, in particular, a derivative of a polyvinyl alcohol, polyethyleneimine or poly vinylamine having a mean molecular weight of at least about 2000 which comprises from about 0.5 to about 80 %, based on the number of hydroxyl groups in the polyvinyl alcohol or the number of imine or amine groups in the polyethyleneimine or polyvinylamine respectively, of units of the formula III or ⁇ la
- R j and R 2 embody amino acid radicals and are, independendy of one another, hydrogen, a C Cgalkyl group, an aryl group, or a cyclohexyl group, where these groups are unsubstituted, monosubstituted or polysubstituted;
- R 3 is hydrogen or a C r C 4 alkyl group, in particular a CH 3 group, and
- R 4 is an -O- or -NH- bridge.
- R 4 is -O-, i.e. an ester link.
- R 4 is -O-, i.e. an ester link.
- Particular preference is given to a radical of the formula Illb
- the novel water-soluble, crosslinkable polymer is therefore, in particular, a derivative of a polyvinyl alcohol having a molecular weight of at least about 2000 which comprises from about 0.5 to about 80 %, based on the number of hydroxyl groups in the polyvinyl alcohol, of units of the formula nib.
- R and R 2 as a C j -Cgalkyl group are linear or branched C r C 8 alkyl and are, for example, the following groups: octyl, hexyl, pentyl, butyl, propyl, ethyl, methyl, 2-propyl, 2-butyl or 3-pentyl.
- R j is preferably hydrogen or CH 3
- R 2 is preferably a C 1 -C alkyl group.
- R j and R 2 as aryl are preferably phenyl.
- substituents can be substituted, examples of suitable substituents being the following: -COOH, -OH, -SH, C C alkoxy (such as methoxy, ethoxy, propoxy, butoxy, isobutoxy), -NO 2 , -NH 2 , -NH(C r C 4 alkyl), -NH-CO-NH 2 , -N(C r C 4 alkyl) 2 , phenyl (unsubstituted or substituted by, for example, -OH or halogen, such as Cl, Br or in particular I), -S C j ⁇ alkyl), 5- or 6-membered heterocyclic rings, such as, in particular, indole or imidazole, -NH-C(NH)-NH 2 , phenoxyphenyl (unsubstituted or substituted by, for example, -OH or halogen, such as Cl, Br or in particular I), an olefinic group, such as vinyl, and CO-NH
- novel water-soluble, crosslinkable polymers are preferably derivatives of polyvinyl alcohol having a mean molecular weight of at least about 2000 which comprises, in particular, from about 1 to 25 %, particularly preferably from about 1 to 12 %, based on the number of hydroxyl groups in the polyvinyl alcohol, of units of the formula HI in which R 4 is an -O- bridge.
- Novel water-soluble, crosslinkable polymers which are intended for the production of contact lenses comprise, in particular, from about 2 to 15 %, especially from 2 to about 12 %, based on the number of hydroxyl groups in the polyvinyl alcohol, of units of the formula III in which R 4 is an -O- bridge.
- Polyvinyl alcohols, polyethyleneimines and polyvinylamines which can be derivatized, for example, in accordance with the invention preferably have a molecular weight of at least 10,000.
- the upper limit to their mean molecular weight is up to 1,000,000. They preferably have a mean molecular weight of up to 300,000, in particular of up to 100,000, very particularly preferably of up to about 50,000 (number average values).
- polyvinyl alcohols which are suitable for the purposes of the invention, usually have, for example, principally a poly(2-hydroxyethylene) structure. However, they can also contain hydroxyl groups in the form of 1,2-glycols, such as copolymer units of 1,2-dihydroxyethylene, as can be obtained, for example, by alkaline hydrolysis of vinyl acetate-vinylene carbonate copolymers.
- polymers derivatized in accordance with the invention can also contain, for example up to 60 %, of copolymer units of ethylene, propylene, acrylamide, methacryla ide, dimethacrylamide, hydroxyethyl methacrylate, methyl methacrylate, methyl acrylate, ethyl acrylate, vinylpyrrolidone, vinyl acetate, vinyl ether, hydroxyethyl acrylate, allyl alcohol, maleic anhydride, maleimide, ethylene glycol derivatives or aldehyde polymers, polymers containing OH groups, polysaccharides, proteins, anhydride polymers, epoxides, water glass or copolymers with OH- styrene.
- Other producers are, for example, Nippon Gohsei (Gohsenol®), Monsanto (Gelvatol®), Wacker (Polyviol®) or the Japanese producers Kuraray, Denki and Shin-Etsu.
- Mowiol® products from Hoechst in particular those of the 3-83, 4-88, 4-98, 6-88, 6-98, 8-88, 8-98, 10-98, 20-98, 26-88 and 40-88 type.
- the PVAs are prepared by basic or acidic, partial or virtually complete hydrolysis of polyvinyl acetate.
- copolymers of hydrolysed or partially hydrolysed vinyl acetate which are obtainable, for example, as hydrolysed ethylene-vinyl acetate (EVA), or vinyl chloride-vinyl acetate, N-vinylpyrrolidone- vinyl acetate and maleic anhydride- vinyl acetate.
- EVA hydrolysed ethylene-vinyl acetate
- vinyl chloride-vinyl acetate vinyl chloride-vinyl acetate
- N-vinylpyrrolidone- vinyl acetate N-vinylpyrrolidone- vinyl acetate and maleic anhydride- vinyl acetate.
- Polyvinyl alcohol is usually prepared by hydrolysis of the corresponding homopolymeric polyvinyl acetate.
- the polyvinyl alcohol derivatized in accordance with the invention comprises less than 50 % of polyvinyl acetate units, in particular less than 20 % of polyvinyl acetate units.
- Preferred amounts of residual acetate units in the polyvinyl alcohol derivatized in accordance with the invention are, based on the total amount of vinyl alcohol units and acetate units, from about 2 to 20 %, preferably from about 2 to 16 %, in particular from 2 to 12 %, especially from 0.5 to 3 %.
- the water-soluble, crosslinkable polymers comprising units of the formula HI or Ilia can be prepared in a manner known per se.
- elevated temperature is taken to mean, in particular, a range of from about 55°C to 75°C, especially 65°C.
- Suitable organic solvents are those which dissolve the polymer backbone. If a polyvinyl alcohol backbone (homopolymer or copolymer) is used, these are, in particular, aprotic polar solvents, for example formamide, dimethylformamide (DMF), hexamethylphosphoric triamide (HMPT) and especially dimethyl sulfoxide (DMSO); furthermore pyridine, nitromethane, acetonitrile, nitrobenzene, chlorobenzene, trichloromethane or dioxane.
- aprotic polar solvents for example formamide, dimethylformamide (DMF), hexamethylphosphoric triamide (HMPT) and especially dimethyl sulfoxide (DMSO); furthermore pyridine, nitromethane, acetonitrile, nitrobenzene, chlorobenzene, trichloromethane or dioxane.
- Catalysts which can be used if desired are, for example, tertiary amines, such as triethylamine, and organotin salts, such as dibutylun dilaurate.
- the preferred catalyst is 1 ,8-diazabicyclo[5.4.0]undec-7-ene (DBU).
- Suitable amino acids are in particular aliphatic amino acids and aromatic amino acids. Examples which may be mentioned arc glycine, alanine, 2-methylalanine, valine, leucine, isoleucine, phenylalanine, tyrosine * , serine*, threonine, cysteine, methionine, tryptophan * , aspartic acid*, glutamic acid * , arginine*, lysine * , histidine * , ⁇ -aminobutyric acid, thyroxine, diiodtyrosine, ⁇ -thiovaline * , ⁇ -methyleneglutamic acid * , ⁇ , ⁇ -diaminobutyric acid*, ornithine * , hydroxylysine * , citrulline * and canavanine * .
- amino acids are aliphatic amino acids, in particular alanine and 2-methylalanine.
- the water-soluble, crosslinkable polymers comprising units of the formula III or ⁇ ia are then isolated as solids, for example by precipitation in acetone.
- the water-soluble, crosslinkable polymers comprising units of the formula III or Etta are extremely stable. This is unexpected to the person skilled in the art since higher-functional acrylates, for example, usually require stabilization. If such compounds are not stabilized, rapid polymerization usually occurs. However, spontaneous crosslinking due to homopolymerizatioh does not occur with the novel water-soluble, crosslinkable polymers.
- These polymers can, in addition, be purified in a manner known per se, for example as mentioned by precipitation with acetone, dialysis or ultrafiltration, particular preference being given to ultrafiltration.
- This purification operation allows the water-soluble, crosslinkable polymers comprising units of the formula HI or Ilia to be obtained in extremely pure form, for example as concentrated aqueous solutions, which are free or at least substantially free from reaction products, such as salts, and starting materials, or other non-polymeric constituents.
- the preferred method for the purification of the novel water-soluble, crosslinkable polymers comprising units of the formula HI or Ilia can be carried out in a manner known per se. It is possible to carry out the ultrafiltration repeatedly, for example from two to ten times. Alternatively, the ultrafiltration can also be carried out continuously until the desired degree of purity has been achieved. The desired degree of purity can in principle be as great as desired.
- a suitable measure of the degree of purity is, for example, the NMR spectrum of the solution in DMSO or the elemental analysis (N 2 -content).
- novel water-soluble, crosslinkable polymers can also comprise further modifier units.
- modifier units Of the many possibilities for such modifiers, the following are mentioned by way of example:
- crosslinkable groups are, for example, those of the formula A
- R is a linear or branched bivalent radical of a alkane, preferably of a Cx-Cgalkane
- Rj is hydrogen, a C r C 6 alkyl group or a cycloalkyl group, preferably a cyclohexyl group
- R 2 is hydrogen or a C r C 6 alkyl radical
- R 4 is hydrogen or C r C 4 alkyl, n is 0 or 1, preferably 0, and
- R 16 and R 1 independently of one another, are hydrogen, linear or branched Cj-Cgalkyl, aryl, preferably phenyl, or cyclohexyl;
- R 15 is hydrogen or a C 1 -C alkyl group, in particular CH 3
- p is from zero to 6, preferably from zero to 2, in particular zero.
- Units which contain a bound photoinitiator are, in particular, those of the formula C
- BR is an or -N — (-CH 2 -)p— bridge or a quaternary salt thereof
- PI is the radical of a photoinitiator from the class consisting of the benzoins, such as benzoin ethers, for example benzoin methyl ether, benzoin ethyl ether, benzoin isopropyl ether and benzoin phenyl ether, and benzoin acetate; acetophenones, such as acetophenone, 2,2-dimethoxyacetophenone and 1,1-dichloroacetophenone; benzil, benzil ketals, such as benzil dimethyl ketal and benzil diethyl ketal; anthraquinones, such as 2-methylanthraquinone, 2-ethylanthraquinone, 2-tert-butyl anthraquinone, 1-chloroanthraquinone and 2-amylanthraquinone; furthermore benzophenones, such as benzophenone and 4,4'-bis(N,N'-dimethyla
- X is -O-, -S- or -N(R 12 )-
- Y is a counterion, such as H 2 SO 4 ⁇ , F ⁇ , Cl ⁇ , Br ⁇ , I ⁇ , CH 3 COO ⁇ , OH ⁇ , BF 4 ⁇ or
- R 3 is hydrogen, a C C 6 alkyl group or a cycloalkyl group
- R 7 is hydrogen; unsubstituted or substituted, linear or branched C j -C ⁇ alkyl;
- R 13 is linear or branched C r C 6 alkyl which is unsubstituted or substituted by -COOH or acrylamide, or an unsubstituted, linear or branched radical of a C 3 -Cg ⁇ lefin,
- Rg is hydrogen, or unsubstituted or substituted, linear or branched C j -C 4 alkyl so long as
- R 7 is not -CO-R 13 .
- R9 is unsubstituted or substituted, linear or branched C Cgalkyl, unsubstituted or substituted, linear or branched a 6-membered carbocyclic or heterocyclic ring, or an unsubstituted linear or branched radical of a C 3 -Cg ⁇ lefin,
- R 10 is a group of the formula -OR 14 or N
- Ri6 R ⁇ is unsubstituted or substituted, linear or branched C r C 6 alkyl, a 6-membered carbocyclic or heterocyclic ring, an unsubstituted, linear or branched radical of a C 3 -Cg ⁇ lefin, or aryl, where
- R and R t l together can also be cyclized to form a 5- or 6-membered carbocyclic ring
- R 12 is hydrogen or unsubstituted, linear or branched C r C 4 alkyl
- R 14 is hydrogen or unsubstituted or substituted, linear or branched C r C 4 alkyl
- R 15 and R 16 independently of one another, are unsubstituted, linear or branched C C alkyl, or R 15 and R 16 can be bonded together to form a 5- or 6-membered heterocyclic ring
- m is O or 1
- n is a number from 1 to 12
- o is a number from 1 to 6
- r is a number from 2 to 6, where substituted radicals are substituted, in particular, by C,-C 4 alkyl or by C r C 4 alkoxy, with the following provisos:
- n is a number from 2 to 12;
- R 14 is not hydrogen if R 9 is a Cj-Cgalkoxy radical
- R is a linear or branched bivalent radical of a C j -C ⁇ alkane
- R 3 is hydrogen, a Cj-Cgalkyl group or a cycloalkyl group
- R 7 is a basic primary, secondary or tertiary amino group, in particular a secondary or tertiary amino group which is substituted by Cj-C 6 alkyl, or a quaternary amino group of the formula
- R' is hydrogen or, independently of one another, a radical, in particular a C j ⁇ alkyl radical
- X is a counterion, for example HSO 4 , ⁇ » Cl®, Br ⁇ , I ⁇ , CH 3 COO ⁇ , OH ⁇ , BF® or H 2 PO 4 ⁇ .
- R and R 3 are as defined under the formula D, and Rg is the radical of a monobasic, dibasic or tribasic aliphatic or aromatic, saturated or unsaturated organic acid.
- units containing crosslinkable groups bonded via urethane or further modifier groups bonded via urethane are those of the formula F or G
- X is a bridge having 2 to 12 carbon atoms, in particular an aliphatic, cycloaliphatic or aromatic bridge, especially alkylene, cyclohexylene or phenylene, which are unsubstituted or in particular substituted by lower alkyl,
- R 2 is hydrogen or a ⁇ alkyl group
- Y is a bridge having 7 to 12 carbon atoms with the same preferences as for X,
- Z is a C_- to C 1 alkylene bridge, which may be interrupted once or more than once by oxygen atoms, and
- A is an organic radical having 1 to 18 carbon atoms, in particular an aliphatic, cycloaliphatic or aromatic radical, especially alkyl, cycloalkyl or phenyl, which are unsubstituted or in particular substituted by lower alkyl.
- units containing a covalendy bonded reactive dye radical are those of the formula H, I, J or K
- RF' is a radical of the formula I — CH 2 — c - R 14 — D
- D is the radical of an organic dye
- R 14 is a divalent electron-withdrawing group
- U is hydrogen or halogen
- R is the divalent radical of a C C 12 alkane
- R j is hydrogen or C 1 -C 4 alkyl
- R 3 is hydrogen, C r C 6 alkyl or cycloalkyl
- Y is -O- or -N(Ri)-.
- novel water-soluble, crosslinkable polymers comprising units of the formula in or Ilia and, if desired, further modifier units as described above can be crosslinked in an extremely effective and targeted manner, in particular by photochemical crosslinking.
- the present invention therefore furthermore relates to a crosslinked, in particular photocross linked polymer which can be obtained by crosslinking a water-soluble, crosslinkable polymer comprising units of the formula III or Ilia in the presence or absence of an additional vinylic comonomer.
- crosslinked polymers hydrogels preferably obtained by photocrosslinking are insoluble in water.
- photocrosslinking In the case of photochemical crosslinking (photocrosslinking), it is expedient to add a photoinitiator which is capable of initiating free-radical crosslinking.
- the crosslinking can then be initiated by actinic or ionizing radiation.
- the photocrosslinking is carried out in a suitable solvent
- solvents are in principle all those which dissolve the polymer backbone, such as polyvinyl alcohol, polyethyleneimine or polyvinylamine, protic and aprotic polar solvents, such as glycols and glycerol and the abovementioned aprotic polar solvents; particular preference is given to water and DMSO.
- the photocrosslinking is preferably carried out directly from an aqueous solution of the novel water-soluble, crosslinkable polymers, which can be obtained as a result of the preferred purification step, namely ultrafiltration, if desired after addition of an additional vinylic comonomer.
- the process for the preparation of the novel crosslinked polymers from the water-soluble, crosslinkable polymers comprising units of the formula III or Ilia comprises, for example, photocrosslinking an appropriate derivative of a polyvinyl alcohol, polyethyleneimine or polyvinylamine which is capable of reacting with an azalactone of the formula U with ring opening, in particular in essentially pure form, ie. for example, after a single or repeated ultrafiltration, in particular in aqueous solution, in the presence or absence of an additional vinylic comonomer.
- the vinylic comonomer which can additionally be used in accordance with the invention in the photocrosslinking can be hydrophilic, hydrophobic or a mixture of hydrophobic and hydrophilic vinylic monomers.
- Suitable vinylic monomers include, in particular, those which are usually used in the production of contact lenses.
- the term "hydrophilic vinylic monomer” is taken to mean a monomer which, as a homopolymer, typically gives a polymer which is soluble in water or is capable of absorbing at least 10 % by weight of water.
- hydrophobic vinylic monomer is taken to mean a monomer which, as a homopolymer, typically gives a polymer which is insoluble in water or is capable of absorbing less than 10 per cent by weight of water.
- the photocrosslinked novel polymers preferably comprise from about 1 to 15 per cent, particularly preferably from about 3 to 8 per cent, of units of the formula HI or Hla, based on die number of hydroxyl groups of the polyvinyl alcohol, which are reacted witi from about 0.1 to 80 units of the vinylic monomer.
- the proportion of vinylic comonomers is preferably from 0.5 to 80 units per unit of the formula UI or Hla, in particular from 1 to 30 units of vinylic comonomer per unit of the formula HI or IHa, particularly preferably from 5 to 20 units per unit of the formula III or Ilia.
- hydrophobic vinylic comonomer or a mixture of a hydrophobic vinylic comonomer and a hydrophilic vinylic comonomer which comprises at least 50 per cent by weight of a hydrophobic vinylic comonomer.
- hydrophobic vinylic comonomers and conventional hydrophilic vinylic comonomers are in principle suitable for the copolymerization with polyvinyl alcohol, polyethyleneimine and polyvinylamine containing groups of the formula HI or EHa.
- Suitable hydrophobic vinylic comonomers include, without this being a comprehensive list, Cj-C j galkyl acrylates and methacrylates, C 3 -C j galkylacrylamides and -methacrylamides, acrylonitrile, methacrylonitrile, vinyl C r C 18 alkanoates, C 2 -C !
- Suitable hydrophobic vinylic comonomers include methyl acrylate, ethyl acrylate, propyl acrylate, isopropyl acrylate, cyclohexyl acrylate, 2-ethylhexyl acrylate, methyl methacrylate, ethyl methacrylate, propyl methacrylate, vinyl acetate, vinyl propionate, vinyl butyrate, vinyl valerate, styrene, chloroprene, vinyl chloride, vinylidene chloride, acrylonitrile, 1-butene, butadiene, methacrylonitrile, vinyltoluene, vinyl ethyl ether, perfluorohexylethylthiocarbonylaminoethyl methacrylate, isobomyl methacrylate, trifluoroethyl methacrylate, hexafluoroisopropyl methacrylate, hexafluorobutyl me
- Suitable hydrophilic vinylic comonomers include, without this being a comprehensive list, hydroxy-substituted lower alkyl acrylates and methacrylates, acrylamide, methacrylamide, lower alkylacrylamides and -methacrylamides, methoxylated acrylates and methacrylates, hydroxy-substituted lower alkylacrylamides and -methacrylamides, hydroxy-substituted lower alkyl vinyl ethers, sodium ethylenesulfonate, sodium styrenesulfonate, 2-acrylamido-2-memylpropanesulfonic acid, N-vinylpyrrole, N-vinylsuccinimide, N- vinylpyrrolidone, 2- and 4-vinylpyridine, acrylic acid, methacrylic acid, amino- (where the term "amino" also covers quaternary ammonium), mono(lower alkyl)amino- or di(lower alkyl)amino
- hydrophilic vinylic comonomers examples include hydroxyethyl methacrylate, hydroxyethyl acrylate, acrylamide, mediacrylamide, dimethylacrylamide, allyl alcohol, vinylpyridine, vinylpyrrolidone, glycerol methacrylate, N-(l,l-dimethyl-3-oxobutyl)acrylamide and the like.
- Preferred hydrophobic vinylic comonomers are methyl methacrylate and vinyl acetate.
- Preferred hydrophilic vinylic comonomers arc 2-hydroxyethyl methacrylate, N-vinylpyrrolidone and acrylamide.
- novel water-soluble, crosslinkable polymers comprising units of the formula IH or ffla can be converted into mouldings, in particular contact lenses, in a manner known per se, for example by carrying out the photocrosslinking of the novel water-soluble, crosslinkable polymers in a suitable contact-lens mould.
- the invention therefore furthermore relates to mouldings essentially comprising a novel water-soluble, crosslinkable polymer.
- novel mouldings besides contact lenses, are biomedical mouldings and mouldings for specifically ophthalmic purposes, for example intraocular lenses, eye bandages, mouldings which can be used in surgery, such as heart valves, artificial arteries or the like, furthermore films and membranes, for example membranes for diffusion control, photostructurable films for information storage, and photoresist materials, for example membranes and mouldings for etch resists and screen printing resists.
- films and membranes for example membranes for diffusion control, photostructurable films for information storage, and photoresist materials, for example membranes and mouldings for etch resists and screen printing resists.
- a specific embodiment of the invention relates to contact lenses which comprise a novel crosslinked polymer made from a water-soluble, crosslinkable polymer comprising units of the formula HI or IHa or essentially comprising or consisting of a novel crosslinked polymer.
- Contact lenses of this type have a range of unusual and extremely advantageous properties, including, for example, excellent compatibility with the human cornea, based on a balanced ratio between water content (about 50-90 % by weight, in particular 60-85 % by weight), high oxygen permeability and very good mechanical properties, for example transparency, clarity, freedom from stresses and tear strength.
- the novel contact lenses have high dimensional stability. Even after autoclaving one or more times at, for example, about 120°C for about 30-40 minutes, no changes in shape are observed.
- novel contact lenses ie. those comprising a crosslinked polymer made from a crosslinkable polymer comprising units of the formula in or Hla
- the starting materials such as the polymer backbones
- the water-soluble, crosslinkable polymers comprising units of d e formula in or ffia are surprisingly stable, so that they can be subjected to very substantial purification.
- the crosslinking can therefore be carried out using a crosslinkable polymer which requires virtually no subsequent purification, such as, in particular, complex extraction of unpolymerized constituents.
- the crosslinking can be carried out in purely aqueous solution, so that a subsequent hydration step is unnecessary.
- the photocrosslinking takes place within less than 5 minutes, so that the process for the production of the novel contact lenses can be designed to be extremely economical from this point of view too.
- novel contact lenses can be produced in a manner known per se, for example in a conventional spin-casting mould, as described, for example, in US-A-3408429, or by the full-mould process in a static mould, as described, for example, in US-A-4347 198.
- the present invention also relates to a novel process for the production of polymeric mouldings, in particular contact lenses, in which a water-soluble crosslinkable polymer comprising crosslinkable units of the formula III or I ⁇ a is crosslinked in solution, and to mouldings, in particular contact lenses, obtainable by this process.
- the mouldings obtainable by crosslinking in this way are insoluble, but swellable, in water.
- d is process for the production of mouldings, in particular contact lenses, comprises the following steps:
- An essentially aqueous solution of a water-soluble, crosslinkable polymer can be prepared in a manner known per se, for example by isolating the water-soluble, crosslinkable polymer, for example in pure form, ie. free from undesired constituents, and dissolving die prepolymer in an essentially aqueous medium.
- crosslinkable polymer is soluble in water
- water-soluble, crosslinkable polymer is soluble in an essentially aqueous solution at 20°C in a concentration of from about 3 to 90 per cent by weight, preferably from about 5 to 60 per cent by weight, in particular from about 10 to 60 per cent by weight
- crosslinkable polymer concentrations of greater than 90 % are also included for the purposes of the invention.
- Particular preference is given to water-soluble, crosslinkable polymer concentrations in solution of from about 15 to about 50 per cent by weight, in particular from about 15 to about 40 per cent by weight, for example from about 25 to about 40 per cent by weight.
- essentially aqueous solutions of the water-soluble, crosslinkable polymer include in particular solutions in water, in aqueous salt solutions, in particular in aqueous salt solutions having an osmolarity of from about 200 to 450 milliosmol in 1000 ml (unit: mOsm/1), preferably an osmolarity of from about 250 to 350 mOsm/1, in particular about 300 mOsm/1, or in mixtures of water or aqueous salt solutions with physiologically acceptable polar organic solvents, for example glycerol.
- Preference is given to solutions of the water-soluble, crosslinkable polymers in water alone.
- aqueous salt solutions are advantageously solutions of physiologically acceptable salts, such as buffer salts, for example phosphate salts, which are conventional in d e area of contact-lens care, or isotonicizing agents, in particular alkali metal halides, for example sodium chloride, which are conventional in the area of contact-lens care, or solutions of mixtures thereof.
- physiologically acceptable salts such as buffer salts, for example phosphate salts, which are conventional in d e area of contact-lens care, or isotonicizing agents, in particular alkali metal halides, for example sodium chloride, which are conventional in the area of contact-lens care, or solutions of mixtures thereof.
- An example of a particularly suitable salt solution is an artificial, preferably buffered tear fluid whose pH and osmolarity have been matched to natural tear fluid, for example an unbuffered, preferably buffered for example by phosphate buffer, sodium chloride solution whose osmolarity and pH conform to
- the above-defined, essentially aqueous solutions of the water-soluble, crosslinkable polymer are preferably pure solutions, ie. diose which are free or essentially free from undesired constituents. Particular preference is given to solutions of die water-soluble, crosslinkable polymer in pure water or in an artificial tear fluid as described above.
- the viscosity of the solution of die water-soluble, crosslinkable polymer in the essentially aqueous solution is unimportant over broad limits. However, it should preferably be a flowable solution which can be shaped without stresses.
- the mean molecular weight of the water-soluble, crosslinkable polymer is likewise unimportant within broad limits.
- the water-soluble, crosslinkable polymer preferably has a mean molecular weight of from about 10,000 to about 200,000.
- Suitable polymeric backbones in addition to polyvinyl alcohol (PVA), polyethyleneimine and polyvinylamine, are materials as have in some cases already been proposed as contact-lens materials, for example polymeric diols other than PVA, polymers comprising saccharides, polymers comprising vinylpyrrolidone, polymers comprising alkyl (meth)acrylates, polymers comprising alkyl (meth)acrylates which are substituted by hydrophilic groups, such as hydroxyl, carboxyl or amino groups, polyalkylene glycols, or copolymers or mixtures thereof.
- PVA polyvinyl alcohol
- polyethyleneimine and polyvinylamine are materials as have in some cases already been proposed as contact-lens materials, for example polymeric diols other than PVA, polymers comprising saccharides, polymers comprising vinylpyrrolidone, polymers comprising alkyl (meth)acrylates, polymers comprising alkyl (meth)acrylates which are substituted by hydrophilic
- the crosslinkable polymer (prepolymer) used in accordance with die invention comprises the units containing one or more different crosslinkable group(s) and, if desired, the units containing the further modifier(s), reactive dye radicals and photoinitiator radicals, etc, in a total amount of from about 0.5 to 80 %, preferably from 1 to 50 %, advantageously from 1 to 25 %, in particular from 2 to 15 %, particularly preferably from 2 to 10 %, based on die number of functional groups in the starting polymer, for example hydroxyl groups in the polyvinyl alcohol.
- Polymers (prepolymers) which can be crosslinked in accordance with die invention and are intended for the production of contact lenses comprise, in particular, from about 0.5 to about 25 %, especially from about 1 to 15 %, particularly preferably from about 2 to 12 , of these units.
- crosslinkable polymer As already mentioned, for a water-soluble, crosslinkable polymer to be suitable in the crosslinking process, it is essential that it is a crosslinkable polymer. However, the crosslinkable polymer is uncrosslinked or at least essentially uncrosslinked, so that it is water-soluble.
- the water-soluble, crosslinkable polymer is advantageously stable in the uncrosslinked state, so that it can be subjected to purification, as described above in connection with compounds comprising units of the formula III or Ilia.
- the water-soluble, crosslinkable polymers are preferably employed in die crosslinking process in the form of pure solutions.
- the water-soluble, crosslinkable polymers can be converted into the form of pure solutions as described below, for example.
- the water-soluble, crosslinkable polymers used in die novel process can preferably be purified in a manner known per se, for example by precipitation with organic solvents, such as acetone, filtration and washing, extraction in a suitable solvent, dialysis or ultrafiltration, particular preference being given to ultrafiltration.
- This purification operation allows the crosslinkable polymers to be obtained in extremely pure form, for example as concentrated aqueous solutions, which are referred to hereinafter as pure or essentially pure.
- This term is understood to refer to a crosslinkable polymer or to a solution thereof which is free or at least substantially free from undesired constituents.
- Undesired constituents in this context are generally all constituents which are physiologically undesired, especially monomeric, oligomeric or polymeric starting compounds used for the preparation of the water-soluble, crosslinkable polymer, or byproducts formed during the preparation of the water-soluble, crosslinkable polymer.
- Preferred degrees of purity of these constituents are less than 0.01 %, in particular less than 0.001 %, very particularly preferably less than 0.0001 % (1 ppm). It is to be noted, however, that there may be present in the solution, for example by formation as byproducts during the preparation of the water-soluble, crosslinkable polymer, constituents which are not undesired from a physiological point of view, such as for example sodium chloride.
- Preferred degrees of purity of these constituents are less than 1 %, in particular less than 0.1 %, very particularly preferably less than 0.01 %. In most cases such levels of constituents may be obtained by applying 3 to 4 repeated ultrafiltration cycles.
- the preferred process for the purification of the water-soluble, crosslinkable polymers used in the crosslinking process namely ultrafiltration, can be carried out in a manner known per se.
- the ultrafiltration can be carried out repeatedly, for example from two to ten times.
- the ultrafiltration can also be carried out continuously until the desired degree of purity has been achieved.
- the desired degree of purity can in principle be chosen to be as great as desired.
- an essentially aqueous solution of the water-soluble, crosslinkable polymer which is essentially free from undesired constituents, for example free from monomeric, oligomeric or polymeric starting compounds used for die preparation of the water-soluble, crosslinkable polymer, and/or free from by-products formed during d e preparation of die water-soluble, crosslinkable polymer, is prepared in step a) and used further.
- This essentially aqueous solution is particularly preferably a purely aqueous solution or a solution in an artificial tear fluid as described above. It is furthermore preferred for the crosslinking process to be carried out without addition of a comonomer, for example a vinylic comonomer.
- die crosslinking process is carried out using a solution of the water-soluble, crosslinkable polymer containing no or essentially no undesired constituents requiring extraction after crosslinking. It is therefore a particular feature of this preferred embodiment of the crosslinking process that extraction of undesired constituents is not necessary after the crosslinking.
- the crosslinking process is therefore preferably carried out in such a way tiiat the essentially aqueous solution of the water-soluble polymer comprising crosslinkable groups is free or essentially free from undesired constituents, in particular from monomeric, oligomeric or polymeric starting compounds used for the preparation of the water-soluble, crosslinkable polymer, or from by-products formed during the preparation of die water-soluble, crosslinkable polymer, and/or mat the solution is used without addition of a comonomer.
- An addition which may be added to the solution of the water-soluble, crosslinkable polymer is a photoinitiator for the crosslinking so long as an initiator is necessary for crosslinking of the crosslinkable groups. This may be the case, in particular, if the crosslinking takes place by photocrosslinking, which is preferred in the novel process.
- an initiator which is capable of initiating free-radical crosslinking and is readily soluble in water.
- suitable photoinitiators which may be mentioned specifically are benzoins, such as benzoin, benzoin ethers, such as benzoin methyl ether, benzoin ethyl ether, benzoin isopropyl ether and benzoin phenyl ether, and benzoin acetate; acetophenones, such as acetophenone, 2,2-dimethoxyacetophenone and 1,1-dichloroacetophenone; benzil, benzil ketals, such as benzil dimetiiyl ketal and benzil diethyl ketal, antiiraquinones, such as 2-methylanthraquinone, 2-ethylanthraquinone, 2-tert-butyland ⁇ raquinone, 1-chloroan
- photoinitiators which are usually used with UV lamps as light source, are acetophenones, such as 2,2-dialkoxybenzophenones and hydroxyphenyl ketones, in particular the initiators known under the trade names IRGACURE®2959 and IRGACURE®1173.
- photoinitiators usually employed when argon ion lasers are used are benzil ketals, for example benzil dimethyl ketal.
- the photoinitiators are added in effective amounts, expediently in amounts of from about 0.3 to about 2.0 % by weight, in particular from 0.3 to 0.5 % by weight, based on die total amount of the water-soluble, crosslinkable polymer.
- the resultant solution can be introduced into a mould using methods known per se, such as, in particular, conventional metering, for example dropwise.
- the novel contact lenses can be produced in a manner known per se, for example in a conventional spin-casting mould, as described, for example, in US-A-3 408 429, or by the full-mould process in a static mould, as described, for example, in US-A-4 347 198.
- Appropriate moulds are made, for example, of polypropylene. Examples of suitable materials for reusable moulds are quartz and sapphire glass.
- the water-soluble, crosslinkable polymers which are suitable in accordance with the invention can be crosslinked by irradiation with ionizing or actinic radiation, for example electron beams, X-rays, UV or VIS light, ie. electromagnetic radiation or particle radiation having a wavelength in the range from about 280 to 650 nm.
- ionizing or actinic radiation for example electron beams, X-rays, UV or VIS light, ie. electromagnetic radiation or particle radiation having a wavelength in the range from about 280 to 650 nm.
- UV lamps He/Cd, argon ion or nitrogen or metal vapour or NdYAG laser beams with multiplied frequency. It is known to the person skilled in die art that each selected light source requires selection and, if necessary, sensitization of the suitable photoinitiator.
- d e crosslinking can also be initiated thermally. It should be emphasized that d e crosslinking can take place in a very short time in accordance with the invention, for example in less than five minutes, preferably in less than one minute, in particular in up to 30 seconds, particularly preferably as described in the examples.
- the crosslinking medium can additionally be any medium in which the crosslinkable polymer is soluble.
- solvents which dissolve polyvinyl alcohol are suitable, such as alcohols, for example ethanol, glycols, glycerol, piperazine (at elevated temperature), diamines, such as triethylenediamine, formamide, dimethylfor amide, hexamethylphosphoric triamide, dimediyl sulfoxide, pyridine, nitromethane, acetonitrile, nitrobenzene, chlorobenzene, trichloromethane, dioxane and aqueous solutions of tetraalkylammonium bromide and iodide.
- the opening of the mould so tiiat die moulding can be removed can be carried out in a manner known per se.
- the process proposed in the prior art (US-A-3408 429 and 4 347 198) requires subsequent purification steps at this point, for example by extraction, and also steps for hydration of die resultant mouldings, in particular contact lenses, such steps are unnecessary here.
- the crosslinked product also comprises no such constituents. Subsequent extraction is therefore unnecessary. Since the crosslinking is carried out in an essentially aqueous solution, subsequent hydration is unnecessary.
- the contact lenses obtainable by the crosslinking process are therefore distinguished, in an advantageous embodiment, by the fact that they are suitable for their intended use without extraction.
- the term 'intended use' in this connection is taken to mean, in particular, that the contact lenses can be employed in die human eye.
- the contact lenses obtainable by die crosslinking process are furthermore distinguished in an advantageous embodiment by the fact that they are suitable for their intended use without hydration.
- Example 1 10.0 g of Mowiol 4-98 (Hoechst AG) were dissolved in 40 ml of DMSO at 65°C with stirring. 0.2 g of the catalyst l,8-diazabicyclo[5.4.0]undec-7-ene (DBU, Fluka) was tiien added, followed by 0.92 g (6.6 mmol, corresponding to 3 mol relative to die OH groups of the PVA) of 2-vinyl-4,4-dimethylazalactone (SNPE-Toulouse). The mixture was allowed to react at 65°C for 24 hours with vigorous stirring. The mixture then contained no free azalactone, which was verified by d e absence of the IR band at 1820 cm" 1 .
- DBU catalyst l,8-diazabicyclo[5.4.0]undec-7-ene
- Example 2 10.0 g of Mowiol 8-88 or 4-88 were reacted as in Example 1 with 0.74 g (5.3 mmol) of 2-vinyl-4,4-dimethylazalactone and 0.2 g DBU in 40 ml of DMSO for 24 hours at 65°C, and die product was purified by precipitation in acetone and reprecipitation in water acetone/EtOH 2/1, isolated and dried (yield 82 %). According to the ⁇ -NMR, the degree of reaction of die free OH groups of the PVA was 3.3 %.
- Example 3 5.0 g of Mowiol 8-88 were reacted as in Example 1 witii 1.10 g (7.9 mmol) of 2-vinyl-4,4-dimethylazalactone and 0.1 g of DBU in 20 ml of DMSO for 24 h at 65 °C and the product was purified by precipitation in acetone and reprecipitation in water, acetone/EtOH 2/1, isolated and dried (yield 57 %). According to die *H-NMR, the degree of reaction of die free OH groups of the PVA was 8.5 %.
- Crosslinking as a 30 % solution in DMSO or water containing 0.5 % of Irgacure®2959 as photoinitiator gave transparent, dimensionally stable, tear-resistant, soft contact lenses having a water content of 76 % (crosslinked in DMSO) or 78 % (crosslinked in water).
- Example 4 (Production of contact lenses by exposure in water) A 35 % aqueous solution of the water-soluble, crosslinkable polymers shown in Table 1 below is mixed with 0.3 % (based on the polymer content) of the photoinitiator Irgacure®2959. The solution is exposed for 10 seconds in a quartz mould (transparent contact-lens mould) using a H ⁇ nle lamp. Table 1
- the lenses are removed from the mould and washed with water. They are then sterilized for 30 minutes at 120°C in an autoclave, giving transparent lenses having the water content shown in Table 1 which are dimensionally stable, comfortable to wear, non-cytotoxic and have very good mechanical properties, slipperiness and rigidity.
- Example 5 (Production of contact lenses by exposure in a DMSO solution) A 30 % solution of the water-soluble, crosslinkable polymers shown in Table 2 below is mixed in DMSO wid 0.5 % (based on die polymer content) of the photoinitiator Irgacure®2959 in a contact-lens mould and exposed as shown in Table 2.
- the lenses are removed from me mould and washed with water. They are then sterilized for 30 minutes at 120°C in an autoclave, giving transparent, clear, dimensionally stable, tear-resistant, soft lenses having the water content shown in Table 2.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
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DE69601924T DE69601924T2 (en) | 1995-02-03 | 1996-01-22 | CROSSLINKED POLYMERS CONTAINING ESTER OR AMID GROUPS |
EP96901751A EP0807270B1 (en) | 1995-02-03 | 1996-01-22 | Crosslinked polymers containing ester or amide groups |
JP52321296A JP3785599B2 (en) | 1995-02-03 | 1996-01-22 | Crosslinked polymers containing ester or amide groups |
US08/875,340 US5849841A (en) | 1995-02-03 | 1996-01-22 | Crosslinked polymers containing ester or amide groups |
AU46205/96A AU4620596A (en) | 1995-02-03 | 1996-01-22 | Crosslinked polymers containing ester or amide groups |
Applications Claiming Priority (2)
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CH311/95 | 1995-02-03 | ||
CH31195 | 1995-02-03 |
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WO1996024075A1 true WO1996024075A1 (en) | 1996-08-08 |
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PCT/EP1996/000246 WO1996024075A1 (en) | 1995-02-03 | 1996-01-22 | Crosslinked polymers containing ester or amide groups |
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US (1) | US5849841A (en) |
EP (1) | EP0807270B1 (en) |
JP (1) | JP3785599B2 (en) |
AT (1) | ATE178414T1 (en) |
AU (1) | AU4620596A (en) |
DE (1) | DE69601924T2 (en) |
IL (1) | IL116899A0 (en) |
WO (1) | WO1996024075A1 (en) |
ZA (1) | ZA96824B (en) |
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US4347198A (en) * | 1977-09-12 | 1982-08-31 | Toray Industries, Ltd. | Producing soft contact lenses |
US4670506A (en) * | 1985-12-23 | 1987-06-02 | Ciba-Geigy Corporation | Polyvinyl alcohol derivatives containing pendant (meth)acryloyl units bound through urethane groups and crosslinked hydrogel contact lenses made therefrom |
EP0321403A2 (en) * | 1987-12-16 | 1989-06-21 | Ciba-Geigy Ag | Polyvinyl alcohol derivatives containing pendant vinylic monomer reaction product units bond through ether groups and hydrogel contact lenses made therefrom |
EP0328340A2 (en) * | 1988-02-09 | 1989-08-16 | BAUSCH & LOMB INCORPORATED | Hydrophilic oxygen permeable polymers |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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TW272976B (en) * | 1993-08-06 | 1996-03-21 | Ciba Geigy Ag |
-
1996
- 1996-01-22 EP EP96901751A patent/EP0807270B1/en not_active Expired - Lifetime
- 1996-01-22 JP JP52321296A patent/JP3785599B2/en not_active Expired - Fee Related
- 1996-01-22 WO PCT/EP1996/000246 patent/WO1996024075A1/en active IP Right Grant
- 1996-01-22 DE DE69601924T patent/DE69601924T2/en not_active Expired - Lifetime
- 1996-01-22 AT AT96901751T patent/ATE178414T1/en not_active IP Right Cessation
- 1996-01-22 US US08/875,340 patent/US5849841A/en not_active Expired - Lifetime
- 1996-01-22 AU AU46205/96A patent/AU4620596A/en not_active Abandoned
- 1996-01-25 IL IL11689996A patent/IL116899A0/en unknown
- 1996-02-02 ZA ZA96824A patent/ZA96824B/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4347198A (en) * | 1977-09-12 | 1982-08-31 | Toray Industries, Ltd. | Producing soft contact lenses |
US4670506A (en) * | 1985-12-23 | 1987-06-02 | Ciba-Geigy Corporation | Polyvinyl alcohol derivatives containing pendant (meth)acryloyl units bound through urethane groups and crosslinked hydrogel contact lenses made therefrom |
EP0321403A2 (en) * | 1987-12-16 | 1989-06-21 | Ciba-Geigy Ag | Polyvinyl alcohol derivatives containing pendant vinylic monomer reaction product units bond through ether groups and hydrogel contact lenses made therefrom |
EP0328340A2 (en) * | 1988-02-09 | 1989-08-16 | BAUSCH & LOMB INCORPORATED | Hydrophilic oxygen permeable polymers |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5997140A (en) * | 1997-12-29 | 1999-12-07 | Novartis Ag | Actively controllable multifocal lens |
US6139146A (en) * | 1997-12-29 | 2000-10-31 | Novartis Ag | Programmable corrective lenses |
US6139147A (en) * | 1998-11-20 | 2000-10-31 | Novartis Ag | Actively controllable multifocal lens |
EP1210034A1 (en) * | 1999-08-02 | 2002-06-05 | Commonwealth Scientific And Industrial Research Organisation | Hydrophilic biomedical compositions |
WO2001008604A1 (en) | 1999-08-02 | 2001-02-08 | Commonwealth Scientific And Industrial Research Organisation | Hydrophilic biomedical compositions |
US6774197B1 (en) | 1999-08-02 | 2004-08-10 | Commonwealth Scientific And Industrial Research Organization | Hydrophilic biomedical composition |
EP1210034A4 (en) * | 1999-08-02 | 2005-02-02 | Commw Scient Andindustrial Res | Hydrophilic biomedical compositions |
US7138471B2 (en) | 1999-08-02 | 2006-11-21 | Commonwealth Scientific And Industrial Research Organisation | Hydrophilic biomedical compositions |
WO2001044307A2 (en) * | 1999-11-15 | 2001-06-21 | Biocure, Inc. | Degradable poly(vinyl alcohol) hydrogels |
WO2001044307A3 (en) * | 1999-11-15 | 2002-02-07 | Biocure Inc | Degradable poly(vinyl alcohol) hydrogels |
US6710126B1 (en) | 1999-11-15 | 2004-03-23 | Bio Cure, Inc. | Degradable poly(vinyl alcohol) hydrogels |
WO2006117228A3 (en) * | 2005-05-05 | 2007-02-01 | Novartis Ag | Ophthalmic devices for sustained delivery of active compounds |
JP2008539837A (en) * | 2005-05-05 | 2008-11-20 | ノバルティス アクチエンゲゼルシャフト | Ophthalmic device for sustained delivery of active compounds |
US9804295B2 (en) | 2005-05-05 | 2017-10-31 | Novartis Ag | Ophthalmic devices for sustained delivery of active compounds |
Also Published As
Publication number | Publication date |
---|---|
JP3785599B2 (en) | 2006-06-14 |
ZA96824B (en) | 1996-08-05 |
DE69601924T2 (en) | 1999-09-30 |
EP0807270B1 (en) | 1999-03-31 |
AU4620596A (en) | 1996-08-21 |
JPH10513126A (en) | 1998-12-15 |
DE69601924D1 (en) | 1999-05-06 |
IL116899A0 (en) | 1996-05-14 |
ATE178414T1 (en) | 1999-04-15 |
EP0807270A1 (en) | 1997-11-19 |
US5849841A (en) | 1998-12-15 |
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