WO1996013289A3 - Verfahren zum befüllen und verschliessen einer mit fluidem inhalt zu sterilisierenden einmalspritze - Google Patents

Verfahren zum befüllen und verschliessen einer mit fluidem inhalt zu sterilisierenden einmalspritze Download PDF

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Publication number
WO1996013289A3
WO1996013289A3 PCT/DE1995/001523 DE9501523W WO9613289A3 WO 1996013289 A3 WO1996013289 A3 WO 1996013289A3 DE 9501523 W DE9501523 W DE 9501523W WO 9613289 A3 WO9613289 A3 WO 9613289A3
Authority
WO
WIPO (PCT)
Prior art keywords
piston
syringe
sterilised
fluid
cylinder
Prior art date
Application number
PCT/DE1995/001523
Other languages
English (en)
French (fr)
Other versions
WO1996013289A2 (de
Inventor
Ulrich Speck
Original Assignee
Schering Ag
Ulrich Speck
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Ulrich Speck filed Critical Schering Ag
Priority to EP95935840A priority Critical patent/EP0788385B1/de
Priority to JP8514252A priority patent/JPH10507670A/ja
Priority to KR1019970702804A priority patent/KR970706858A/ko
Priority to DE59502539T priority patent/DE59502539D1/de
Priority to US08/817,758 priority patent/US6129711A/en
Publication of WO1996013289A2 publication Critical patent/WO1996013289A2/de
Publication of WO1996013289A3 publication Critical patent/WO1996013289A3/de
Priority to FI971710A priority patent/FI971710A0/fi
Priority to NO971948A priority patent/NO971948L/no
Priority to MXPA/A/1997/003085A priority patent/MXPA97003085A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
    • A61M2005/3139—Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/3278—Apparatus for destroying used needles or syringes
    • A61M2005/3279—Breaking syringe nozzles or needle hubs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/001—Apparatus specially adapted for cleaning or sterilising syringes or needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/1782—Devices aiding filling of syringes in situ
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles

Abstract

Die vorliegende Erfindung betrifft ein Verfahren zum Befüllen und Verschließen einer mit fluidem Inhalt zu sterilisierenden Einmalspritze aus Kunststoff, wobei die Einmalspritze einen Spritzenzylinder (11) mit einem vorn angeformten Düsenteil (20), einen zumindest einteiligen Kolben oder Kolbenstopfen (30) und ein im Bereich der Zylindergriffplatte (12) angeordnetes Kolbenanschlagelement (40) umfaßt. Der Kolben (30) wird nach dem Einsetzen in den leeren Spritzenzylinder (11) mit oder ohne die eigene Kolbenstange vollständig bis an dessen vorderes Ende eingeschoben. Anschließend wird das fluide Medium unter Druck über das Düsenteil (20) in den Spritzenzylinder (11) gepreßt, wobei das fluide Medium den Kolben (30) in Richtung Kolbenstangenseite bis an das Kolbenanschlagelement (40) vor sich herschiebt. Nach dem Befüllen wird der vordere Bereich (25) des Düsenteils (20) durch plastische Verformung verschlossen. Mit Hilfe des vorliegenden Verfahrens kann eine vorbefüllte Einmalspritze in einem Standardautoklaven sterilisiert werden, ohne daß aufgrund des Spritzeninnendrucks für die Spritzenteile die Gefahr des plastischen Verformens besteht.
PCT/DE1995/001523 1994-10-28 1995-10-27 Verfahren zum befüllen und verschliessen einer mit fluidem inhalt zu sterilisierenden einmalspritze WO1996013289A2 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP95935840A EP0788385B1 (de) 1994-10-28 1995-10-27 Mit fluidem inhalt zu sterilisierenden einmalspritze
JP8514252A JPH10507670A (ja) 1994-10-28 1995-10-27 流動内容物と共に滅菌される使い捨て注射器を充填及び閉鎖する方法
KR1019970702804A KR970706858A (ko) 1994-10-28 1995-10-27 살균될 유체 내장 일회용 주사기를 충전하고 밀봉하는 방법(process for filling with a fluid and closing disposable syringes that are to be sterilised)
DE59502539T DE59502539D1 (de) 1994-10-28 1995-10-27 Mit fluidem inhalt zu sterilisierenden einmalspritze
US08/817,758 US6129711A (en) 1994-10-28 1995-10-27 Fluid-containing plastic disposable syringe that is to be sterilized and a process for filling and sealing same
FI971710A FI971710A0 (fi) 1994-10-28 1997-04-22 Fluidisisällöllä steriloitavan kertakäyttöruiskun täyttämis- ja sulkemismenetelmä
NO971948A NO971948L (no) 1994-10-28 1997-04-25 Fremgangsmåte for fylling og stenging av en engangsspröyte som skal steriliseres med fluidinnhold
MXPA/A/1997/003085A MXPA97003085A (en) 1994-10-28 1997-04-28 Procedure for filling with a fluid and closing plastic disposable that will be used and the syringes that are obtained

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4439738 1994-10-28
DEP4439738.0 1994-10-28

Publications (2)

Publication Number Publication Date
WO1996013289A2 WO1996013289A2 (de) 1996-05-09
WO1996013289A3 true WO1996013289A3 (de) 1996-08-01

Family

ID=6532690

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1995/001523 WO1996013289A2 (de) 1994-10-28 1995-10-27 Verfahren zum befüllen und verschliessen einer mit fluidem inhalt zu sterilisierenden einmalspritze

Country Status (10)

Country Link
US (1) US6129711A (de)
EP (1) EP0788385B1 (de)
JP (1) JPH10507670A (de)
KR (1) KR970706858A (de)
AT (1) ATE167064T1 (de)
CA (1) CA2203908A1 (de)
DE (1) DE59502539D1 (de)
FI (1) FI971710A0 (de)
NO (1) NO971948L (de)
WO (1) WO1996013289A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19652708C2 (de) * 1996-12-18 1999-08-12 Schott Glas Verfahren zum Herstellen eines befüllten Kunststoff-Spritzenkorpus für medizinische Zwecke
EP2253548A1 (de) 1998-03-13 2010-11-24 Becton, Dickinson and Company Methode zur Herstellung, Befüllen und Verpacken von medizinischen Behältern
DE19851420A1 (de) * 1998-11-07 2000-05-11 Inova Pac Systeme Gmbh Vorrichtung zum Befüllen
DE19918721A1 (de) 1999-04-24 2000-11-02 Inova Pac Systeme Gmbh Verfahren und Vorrichtung zum Befüllen von nadelfreien Injektoren
DE10058496B4 (de) * 2000-11-24 2006-12-28 Air Liquide Deutschland Gmbh Einrichtung zur Entnahme von Gasen über eine Spritze
US6485460B2 (en) 2001-01-12 2002-11-26 Bracco Diagnostics, Inc. Tamper evident syringe barrel
EP1368083A1 (de) * 2001-03-06 2003-12-10 PHARMACIA & UPJOHN COMPANY Applikator mit partiell einführbarer kanüle
CN1226059C (zh) * 2003-05-21 2005-11-09 江西洪达医疗器械集团有限公司 自毁式安全注射器
JP4986600B2 (ja) * 2006-12-20 2012-07-25 武蔵エンジニアリング株式会社 閉蓋具および液体材料貯留容器
JP5265666B2 (ja) 2008-04-01 2013-08-14 生化学工業株式会社 薬液吐出部密封キャップ
US8752722B2 (en) 2008-09-29 2014-06-17 Vifor (International) Ag Cap assembly and production method
RU2466754C1 (ru) * 2008-09-29 2012-11-20 Вифор (Интернациональ) Аг Колпачок в сборе и способ изготовления
TW201129402A (en) * 2009-12-16 2011-09-01 Star Syringe Ltd Syringes
US20110315720A1 (en) * 2010-06-28 2011-12-29 Unicep Packaging, Inc. Dispenser with twist lock fitting
JP5372196B2 (ja) * 2012-03-28 2013-12-18 武蔵エンジニアリング株式会社 閉蓋具および液体材料貯留容器

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CH360168A (de) * 1958-01-23 1962-02-15 Ciba Geigy Als Injektionsspritze verwendbare Ampulle
DE1239061B (de) * 1961-09-15 1967-04-20 Rota Patent A G Verfahren zum Fuellen und Verschliessen von Ampullen, insbesondere fuer die Aufnahmevon Medikamenten u. dgl.
EP0107874A1 (de) * 1982-10-27 1984-05-09 Duphar International Research B.V Automatische Injektionsvorrichtung
GB2249727A (en) * 1989-11-16 1992-05-20 Duoject Inc Syringe vial
WO1993021986A2 (en) * 1992-04-28 1993-11-11 Schering-Plough Healthcare Products, Inc. Applicator for semisolid medications
WO1994026332A1 (en) * 1993-05-17 1994-11-24 Reynolds David L Improvements in pharmaceutical containers

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US3828775A (en) * 1969-02-06 1974-08-13 Iso Nuclear Corp Self-packaged hypodermic syringe
US4051850A (en) * 1975-11-21 1977-10-04 Tischlinger Edward A Disposable medicament injector
US4850970A (en) * 1987-03-26 1989-07-25 American Home Products, Corp. Two part mastitis cannula cap
US5009640A (en) * 1989-01-19 1991-04-23 The Upjohn Company Slip cap for cannula use
US5084017A (en) * 1989-10-10 1992-01-28 John Maffetone Self disabling, single use, hypodermic syringe
US4981472B2 (en) * 1989-11-20 1996-12-24 Mark Anderson Cannula assembly for syringe
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US5147325A (en) * 1991-05-03 1992-09-15 Sherwood Medical Company Rigid needle shield
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US5538506A (en) * 1993-11-03 1996-07-23 Farris; Barry Prefilled fluid syringe

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH360168A (de) * 1958-01-23 1962-02-15 Ciba Geigy Als Injektionsspritze verwendbare Ampulle
DE1239061B (de) * 1961-09-15 1967-04-20 Rota Patent A G Verfahren zum Fuellen und Verschliessen von Ampullen, insbesondere fuer die Aufnahmevon Medikamenten u. dgl.
EP0107874A1 (de) * 1982-10-27 1984-05-09 Duphar International Research B.V Automatische Injektionsvorrichtung
GB2249727A (en) * 1989-11-16 1992-05-20 Duoject Inc Syringe vial
WO1993021986A2 (en) * 1992-04-28 1993-11-11 Schering-Plough Healthcare Products, Inc. Applicator for semisolid medications
WO1994026332A1 (en) * 1993-05-17 1994-11-24 Reynolds David L Improvements in pharmaceutical containers

Also Published As

Publication number Publication date
CA2203908A1 (en) 1996-05-09
DE59502539D1 (de) 1998-07-16
US6129711A (en) 2000-10-10
KR970706858A (ko) 1997-12-01
NO971948L (no) 1997-06-26
EP0788385B1 (de) 1998-06-10
WO1996013289A2 (de) 1996-05-09
FI971710A (fi) 1997-04-22
JPH10507670A (ja) 1998-07-28
MX9703085A (es) 1997-07-31
ATE167064T1 (de) 1998-06-15
FI971710A0 (fi) 1997-04-22
EP0788385A1 (de) 1997-08-13
NO971948D0 (no) 1997-04-25

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