WO1996006777A1 - System for dosing fluids - Google Patents

System for dosing fluids Download PDF

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Publication number
WO1996006777A1
WO1996006777A1 PCT/US1995/010849 US9510849W WO9606777A1 WO 1996006777 A1 WO1996006777 A1 WO 1996006777A1 US 9510849 W US9510849 W US 9510849W WO 9606777 A1 WO9606777 A1 WO 9606777A1
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
supply pipe
supply line
supply
source
Prior art date
Application number
PCT/US1995/010849
Other languages
French (fr)
Inventor
Frederick Tim Strand
Original Assignee
Nutrition International, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrition International, Inc. filed Critical Nutrition International, Inc.
Priority to AU34161/95A priority Critical patent/AU3416195A/en
Publication of WO1996006777A1 publication Critical patent/WO1996006777A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
    • B65B3/10—Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material
    • B65B3/12—Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material mechanically, e.g. by pistons or pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B57/00—Automatic control, checking, warning, or safety devices
    • B65B57/10—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of articles or materials to be packaged
    • B65B57/14—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of articles or materials to be packaged and operating to control, or stop, the feed of articles or material to be packaged
    • B65B57/145—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of articles or materials to be packaged and operating to control, or stop, the feed of articles or material to be packaged for fluent material

Definitions

  • Packaging systems are widely used for packaging fluids in a variety of containers.
  • the containers include metal cans, plastic and paperboard bottles, and aseptic laminated boxes.
  • the latter are used to store a variety of products, including milk, for long periods of time without refrigeration.
  • Aseptic packaging systems require the liquids to be sterilized prior to supplying the liquids to the packaging machine, and throughout the packaging process. Aseptic packaging of fluids, including milk, has been successfully carried out for a number of years.
  • Equipment has been designed for effecting aseptic dosage of fluids, including milk, which is coupled into the supply ' ine to the packaging machine by means of a T-coupler.
  • a T-coupler typically, such a unit includes a source of the dosing liquid, which is withdrawn by means of a dosing pump, through a filter to remove particles (such as bacteria and spores) greater than 0.2 microns, to produce a sterilized dosing liquid.
  • the pump then supplies the sterilized liquid into the "T" connection, where it mixes with the primary fluid which has been heat sterilized.
  • the apparatus for effecting the dosing of a fluid in this manner must be pre-sterilized before production can commence.
  • the filter and all of the pipes, including the pump are sterilized by means of steam for several minutes prior to operation.
  • the interconnection of such a system is intended to be relatively permanent; and the dosing pump, tank, pipes and assorted control apparatus is quite bulky.
  • commercially available dosing units of this type are quite complex and expensive.
  • a system and method for dosing fluid employs a source of the fluid to be dosed and a packaging machine for the fluid, interconnected with the source by means of a supply pipe.
  • a source of sterile dosing liquid is coupled through a peristaltic pump to a hypodermic needle inserted into said supply pipe to supply the dosing liquid at a rate determined by the operation of the pump.
  • the flow of fluid from the source of fluid to the packaging machine is controlled by a flow control, which in turn has the rate of operation controlled by a computer control monitor, which also may control the operation of the pump with the flow control of the fluid in the supply pipe.
  • Figure 1 is a block diagram of a preferred embodiment of the invention; and Figure 2 is an enlarged detail of a portion of the system shown in Figure 1.
  • the system of a preferred embodiment of the invention is illustrated in conjunction with a system for packaging milk from a supply 10 in a packaging machine 22.
  • the packaged output from the packaging machine 22 is indicated at 24, and may constitute bottled milk (in plastic, paperboard or glass) or aseptically packaged milk in laminated aseptic cartons.
  • the milk supply 10 typically is a relatively large tank, from which the milk 10 is supplied to a flow control valve 14, and from there through a pipe 15 to a pasteurizer or sterilizer 16.
  • a flow control valve 14 regulates the flow of milk under the control of a computer control monitor 26, which also controls the operation of the packaging machine 22; so that the flow of milk or other fluid through the system from the supply tank 10 to the packaging machine 22 is synchronized to the operation of the packaging machine 22.
  • the computer control monitor continuously receives feedback from and supplies signals to the packaging machine 22 and the flow control valve 14 to ensure that the rate of supply is synchronized throughout the operation of the system.
  • a source of sterile dosing liquid 30 is provided.
  • the sterile dosing liquid comprises a known pre-sterilized lactose destroying enzyme.
  • a pump 34 preferably a peristaltic pump as indicated in Figure 2 is then coupled on a flexible plastic or nylon supply line 33 to pump dosing liquid through the line 33 from the supply or reservoir 30 of dosing liquid in a conventional manner.
  • Pumps which are found highly suitable for use as the pump 34 comprise medical IV line pumps, such as the Baxter ® FloGard ® 6200, or the like.
  • These pumps clamp over a flexible hollow plastic supply line; so that they do not come into contact with the fluid which is being pumped, but use a peristaltic action to remove fluid from the supply, such as the sterile dosing liquid supply 30 shown in Figures 1 and 2, and pump the liquid into a hypodermic needle 36 or other utilization device.
  • the lower or output end of the flexible supply line 33 is coupled to a hypodermic needle 36 in a standard manner.
  • the needle 36 preferably is a 14 or 18 gauge medical IV hypodermic needle. Such needles are readily available and widely used in medical applications.
  • the needle 36 is inserted through the rubber O ring or flexible gasket 19, as illustrated in Figure 2.
  • Sterile dosing liquid (which, for milk, may be a lactose destroying enzyme) from the source 30 is supplied through the flexible supply line 33 to the needle 36 from which it is injected into the fluid flowing through the pipe sections 18 and 20 to the packaging machine 22.
  • a spline tube or other mixer (not shown) may be used in the pipe section to ensure thorough mixing of the dosing liquid and the fluid from the supply 10.
  • the computer control monitor 26 may be interconnected with the pump 34, as well as the flow control valve 14 and the packaging machine 22, to coordinate and synchronize the operation of all these components of the system with one another.
  • the rate of supply of the sterile dosing liquid by the pump 34 is determined by the amount of fluid flowing from the supply 10 and flow control 14 through the pasteurizer or sterilizer 16, as well as the proportion of dosing liquid 30 which is required for the particular application.
  • the inexpensive sterile supply line 33 and readily available sterile hypodermic needle 19 are interconnected with the dosing liquid reservoir 30 and the resilient gasket or O ring 19, as described above, without requiring any additional sterilization at the installation site. Since the pump 34 is a peristaltic pump, no sterilization of the pump 34 is necessary. As a consequence, the system inexpensively may be employed in any given packaging plant and on any line in the plant, as desired.
  • the hypodermic needle 36 is removed; and the resiliency of the gasket or O-ring 19 seals the opening.
  • the system then operates in a conventional manner without the dosing unit connected to it.

Abstract

A system for delivering sterile dosing liquid to fluid flowing through a supply pipe (18, 20) from a source of fluid (10) to a packaging machine (22) utilizes a peristaltic pump (34) connected to a flexible supply line (33) from the source of sterile dosing liquid (30) to a hollow needle (36). The supply pipe comprises at least two sections (18, 20), interconnected together with a resilient rubber-like gasket (19); and said hollow needle (36) is inserted through said gasket (19) to supply sterile dosing liquid to the fluid flowing through the supply pipe.

Description

System for Dosing Fluids
BACKGROUND
Packaging systems are widely used for packaging fluids in a variety of containers. The containers include metal cans, plastic and paperboard bottles, and aseptic laminated boxes. The latter are used to store a variety of products, including milk, for long periods of time without refrigeration. Aseptic packaging systems require the liquids to be sterilized prior to supplying the liquids to the packaging machine, and throughout the packaging process. Aseptic packaging of fluids, including milk, has been successfully carried out for a number of years.
It has been found desirable to apply dosing of fluids, such as milk, prior to the packaging of these fluids in an aseptic packaging machine to add vitamins, flavorings, colorings, enzymes or other products which are not suitable for sterilization by heat. As a consequence, such dosing products cannot be added prior to the pasteurization or heat sterilization of the milk or other fluid, but must be supplied to the fluid between the sterilizing stage and the packaging machine. This is particularly true of lactose destroying enzymes, which are added to milk prior to packaging for producing lactose reduced milk. Such milk is necessary for use by persons who are lactose intolerant; and a substantial market exists in many parts of the world for lactose reduced milk products.
Equipment has been designed for effecting aseptic dosage of fluids, including milk, which is coupled into the supply ' ine to the packaging machine by means of a T-coupler. Typically, such a unit includes a source of the dosing liquid, which is withdrawn by means of a dosing pump, through a filter to remove particles (such as bacteria and spores) greater than 0.2 microns, to produce a sterilized dosing liquid. The pump then supplies the sterilized liquid into the "T" connection, where it mixes with the primary fluid which has been heat sterilized.
The apparatus for effecting the dosing of a fluid in this manner must be pre-sterilized before production can commence. Typically, the filter and all of the pipes, including the pump, are sterilized by means of steam for several minutes prior to operation. The interconnection of such a system is intended to be relatively permanent; and the dosing pump, tank, pipes and assorted control apparatus is quite bulky. In addition, commercially available dosing units of this type are quite complex and expensive.
It is desirable to provide a dosing system and method which overcome the disadvantages of the prior art and which are simple, inexpensive, effective in operation, and portable.
SUMMARY OF THE INVENTION
It is an object of this invention to provide an improved dosing system and method.
It is another object of this invention to provide an improved system suitable for aseptic dosing of fluids with a dosing liquid.
It is still another object of this invention to provide a simple system and method for dosing milk with sterile lactose destroying enzymes.
It is a further object of this invention to provide a system and method for dosing sterilized fluids by injecting the dosing liquid into the fluids through a hollow needle inserted into a resilient coupler interconnecting two sections of pipe carrying the fluid to be dosed and using a peristaltic pump to supply the dosing liquid to the fluid in the pipe.
In accordance with a preferred embodiment of the invention, a system and method for dosing fluid employs a source of the fluid to be dosed and a packaging machine for the fluid, interconnected with the source by means of a supply pipe. A source of sterile dosing liquid is coupled through a peristaltic pump to a hypodermic needle inserted into said supply pipe to supply the dosing liquid at a rate determined by the operation of the pump.
In a more specific embodiment of the invention, the flow of fluid from the source of fluid to the packaging machine is controlled by a flow control, which in turn has the rate of operation controlled by a computer control monitor, which also may control the operation of the pump with the flow control of the fluid in the supply pipe. BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1 is a block diagram of a preferred embodiment of the invention; and Figure 2 is an enlarged detail of a portion of the system shown in Figure 1. DETAILED DESCRIPTION
Reference now should be made to the drawing, in which the same reference numbers are used throughout the different figures to designate the same components. The system of a preferred embodiment of the invention is illustrated in conjunction with a system for packaging milk from a supply 10 in a packaging machine 22. The packaged output from the packaging machine 22 is indicated at 24, and may constitute bottled milk (in plastic, paperboard or glass) or aseptically packaged milk in laminated aseptic cartons.
In a system of the type shown in Figure 1, the milk supply 10 typically is a relatively large tank, from which the milk 10 is supplied to a flow control valve 14, and from there through a pipe 15 to a pasteurizer or sterilizer 16. Once the milk has been pasteurized in the unit 16, it then is supplied through a first section 18 of a supply pipe coupled through a resilient coupler 19 to a second section 20 of a supply pipe to the packaging machine 22. The flow control valve 14 regulates the flow of milk under the control of a computer control monitor 26, which also controls the operation of the packaging machine 22; so that the flow of milk or other fluid through the system from the supply tank 10 to the packaging machine 22 is synchronized to the operation of the packaging machine 22. As a consequence, the computer control monitor continuously receives feedback from and supplies signals to the packaging machine 22 and the flow control valve 14 to ensure that the rate of supply is synchronized throughout the operation of the system.
The system described thus far is utilized as a standard system, in conjunction with the aseptic packaging of many different fluids, including milk. It should be noted that the resilient coupler or "O" ring 19, shown in greater detail in Figure 2, which interconnects the two ends of the pipe sections 18 and 20, typically is clamped to the pipe sections 20 by means of a suitable clamp (not shown) . Since such clamps are common and are well known, the details of the clamp have not been shown in Figures 1 and 2 for the purpose of more clearly illustrating the features of the invention. To dose milk or other fluids with sterile dosing liquids including, but not limited to vitamins, flavors, enzymes, and the like, the dosing liquids must be added to the milk or other fluids prior to supplying the fluids to the packaging machine 22. The remainder of the elements shown in Figures 1 and 2 have been developed in accordance with the invention to provide a low cost, portable, universal dosing system and method.
As illustrated in both Figures 1 and 2, a source of sterile dosing liquid 30 is provided. For a system used to produce lactose reduced milk, the sterile dosing liquid comprises a known pre-sterilized lactose destroying enzyme. A pump 34, preferably a peristaltic pump as indicated in Figure 2, is then coupled on a flexible plastic or nylon supply line 33 to pump dosing liquid through the line 33 from the supply or reservoir 30 of dosing liquid in a conventional manner. Pumps which are found highly suitable for use as the pump 34 comprise medical IV line pumps, such as the Baxter® FloGard® 6200, or the like. These pumps clamp over a flexible hollow plastic supply line; so that they do not come into contact with the fluid which is being pumped, but use a peristaltic action to remove fluid from the supply, such as the sterile dosing liquid supply 30 shown in Figures 1 and 2, and pump the liquid into a hypodermic needle 36 or other utilization device. As illustrated most clearly in Figure 2, the lower or output end of the flexible supply line 33 is coupled to a hypodermic needle 36 in a standard manner. The needle 36 preferably is a 14 or 18 gauge medical IV hypodermic needle. Such needles are readily available and widely used in medical applications. The needle 36 is inserted through the rubber O ring or flexible gasket 19, as illustrated in Figure 2. Sterile dosing liquid (which, for milk, may be a lactose destroying enzyme) from the source 30 is supplied through the flexible supply line 33 to the needle 36 from which it is injected into the fluid flowing through the pipe sections 18 and 20 to the packaging machine 22. Depending upon the physical characteristics of the system, a spline tube or other mixer (not shown) may be used in the pipe section to ensure thorough mixing of the dosing liquid and the fluid from the supply 10.
The computer control monitor 26 may be interconnected with the pump 34, as well as the flow control valve 14 and the packaging machine 22, to coordinate and synchronize the operation of all these components of the system with one another. The rate of supply of the sterile dosing liquid by the pump 34 is determined by the amount of fluid flowing from the supply 10 and flow control 14 through the pasteurizer or sterilizer 16, as well as the proportion of dosing liquid 30 which is required for the particular application.
It should be noted that by supplying the sterile dosing liquid 30 as a pre-packaged sterile supply (which may be in the form of plastic bags or the like, of the type used in medical IV applications) no sterilization of the dosing liquid or filtration of the dosing liquid needs to be effected. In addition, the inexpensive sterile supply line 33 and readily available sterile hypodermic needle 19 are interconnected with the dosing liquid reservoir 30 and the resilient gasket or O ring 19, as described above, without requiring any additional sterilization at the installation site. Since the pump 34 is a peristaltic pump, no sterilization of the pump 34 is necessary. As a consequence, the system inexpensively may be employed in any given packaging plant and on any line in the plant, as desired. When the sterile dosing liquid no longer is required for a particular packaging line, the hypodermic needle 36 is removed; and the resiliency of the gasket or O-ring 19 seals the opening. The system then operates in a conventional manner without the dosing unit connected to it.
By employing the simple system which is described above, significant cost savings are effected. Sterilization of the system readily may be maintained by utilizing regular replacements of the flexible fluid supply line 33 and hypodermic needle 19, as required. These are relatively inexpensive components; and no expensive steam sterilization of these components is necessary, since they are purchased in a pre- sterilized condition. The system which has been described is particularly effective in producing lactose reduced milk for aseptic packaging; and this is a primary application envisioned for the system. The foregoing description of the preferred embodiment of the invention should be considered as illustrative and not as limiting. Various changes and modifications will occur to those skilled in the art for performing substantially the same function, in substantially the same way, to achieve substantially the same result, without departing from the true scope of the invention as defined in the appended claims.

Claims

WHAT IS CLAIMED IS
1. A system for supplying a dosing liquid to fluid from a source of fluid to be packaged by a packaging apparatus where a supply pipe is connected between the source of fluid and the packaging apparatus for supplying fluid from said source to said packaging apparatus, said system characterized by: a source of sterile dosing liquid; a peristaltic pump; a supply line connected through said peristaltic pump between the source of sterile dosing liquid and the supply pipe for supplying sterile dosing liquid to fluid flowing through the supply pipe from the source of fluid to the packaging apparatus.
2. The system according to Claim 1 further characterized by a flow control device connected in the supply pipe for causing the flow of fluid from the source of fluid to the packaging machine to be at a predetermined rate; and a monitor device connected with the flow control device and the pump for controlling the operation of the pump to supply the sterile dosing liquid at a rate corresponding to the predetermined rate of flow of fluid through the supply pipe.
3. The system according to Claim 2 characterized in that the monitor device is a computer control monitor.
4. The system according to Claim 3 characterized in that the supply line is a flexible supply line.
5. The system according to Claim 4 characterized in that the supply pipe is comprised of at least two sections coupled together with a resilient coupler; and further characterized by a hollow needle coupled to the supply line and having a tip inserted through the flexible coupler.
6. The system according to Claim 5 characterized in that the hollow needle comprises a hypodermic needle and the supply line comprises a flexible plastic line.
7. The system according to Claim 6 characterized in that the resilient coupler between the first and second sections of the supply pipe comprises a rubber-like gasket.
8. The system according to Claim 1 characterized in that the supply pipe is comprised of at least two sections coupled together with a resilient coupler; and further characterized by a hollow needle coupled to the supply line and having a tip inserted through the flexible coupler.
9. The system according to Claim 8 characterized in that the hollow needle comprises a hypodermic needle and the supply line comprises a flexible plastic line.
10. The system according to Claim 1 characterized in that the supply line is a flexible supply line.
11. The system according to Claim 1 characterized in that the fluid is milk and the sterile dosing liquid includes lactose-destroying enzymes.
12. The system according to Claim 11 further characterized by a flow control device connected in the supply pipe for causing the flow of fluid from the source of fluid to the packaging machine to be at a predetermined rate; and a monitor device connected with the flow control device and the pump for controlling the operation of the pump to supply the sterile dosing liquid at a rate corresponding to the predetermined rate of flow of fluid through the supply pipe.
13. The system according to Claim 12 characterized in that the supply pipe is comprised of at least two sections coupled together with a resilient coupler; and further characterized by a hollow needle coupled to the supply line and having a tip inserted through the flexible coupler.
14. The system according to Claim 13 characterized in that the hollow needle comprises a hypodermic needle and the supply line comprises a flexible plastic line.
15. The system according to Claim 14 characterized in that the resilient coupler between the first and second sections of the supply pipe comprises a rubber-like gasket.
AMENDED CLAIMS
[received by the International Bureau on 15 December 1995(15.12.95); original claims 1-15 replaced by amended claims 1-13; (4 pages)]
1. A system for supplying a dosing liquid to fluid from a source of fluid to be packaged by a packaging apparatus where a supply pipe is connected between the source of fluid and the packaging apparatus for supplying fluid from said source to said packaging apparatus, said system characterized by: a source of pre-packaged sterile dosing liquid; a peristaltic pump; a supply line connected through said peristaltic pump to the source of pre-packaged sterile dosing liquid and releasably connected the supply pipe for supplying sterile dosing liquid to fluid flowing through the supply pipe from the source of fluid to the packaging apparatus; a flow control device connected in the supply pipe for causing the flow of fluid from the source of fluid to the packaging machine to be at a predetermined rate; and a monitor device connected with the flow control device and the pump for controlling the operation of the pump to supply the sterile dosing liquid at a rate corresponding to the predetermined rate of flow of fluid through the supply pipe.
2. The system according to Claim 1 characterized in that the monitor device is a computer control monitor. 3. The system according to Claim 2 characterized in that the supply line is a flexible supply line.
. The system according to Claim 3 characterized in that the supply pipe has a resilient coupler therein; and further characterized by a hollow needle coupled to the supply line and having a tip inserted through the flexible coupler.
5. The system according to Claim 4 characterized in that the hollow needle comprises a hypodermic needle and the supply line comprises a flexible plastic line.
6. The system according to Claim 5 characterized in that the resilient coupler comprises rubber-like material.
7. The system according to Claim 1 characterized in that the supply pipe has a resilient coupler therein; and further characterized by a hollow needle coupled to the supply line and having a tip inserted through the flexible coupler. 8. The system according to Claim 7 characterized in that the hollow needle comprises a hypodermic needle and the supply line comprises a flexible plastic line.
9. The system according to Claim 1 characterized in that the supply line is a flexible supply line.
10. The system according to Claim 1 characterized in that the fluid is milk and the sterile dosing liquid includes lactose-destroying enzymes.
11. The system according to Claim 10 characterized in that the supply pipe has a resilient coupler therein; and further characterized by a hollow needle coupled to the supply line and having a tip inserted through the flexible coupler.
12. The system according to Claim 11 characterized in that the hollow needle comprises a hypodermic needle and the supply line comprises a flexible plastic line. 15
13. The system according to Claim 12 characterized in that the resilient coupler comprises rubber-like material.
PCT/US1995/010849 1994-08-26 1995-08-25 System for dosing fluids WO1996006777A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU34161/95A AU3416195A (en) 1994-08-26 1995-08-25 System for dosing fluids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29670394A 1994-08-26 1994-08-26
US08/296,703 1994-08-26

Publications (1)

Publication Number Publication Date
WO1996006777A1 true WO1996006777A1 (en) 1996-03-07

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ID=23143187

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Application Number Title Priority Date Filing Date
PCT/US1995/010849 WO1996006777A1 (en) 1994-08-26 1995-08-25 System for dosing fluids

Country Status (3)

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CN (1) CN1168656A (en)
AU (1) AU3416195A (en)
WO (1) WO1996006777A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2956092B1 (en) * 2010-02-10 2012-02-24 Sartorius Stedim Biotech Sa METHOD AND STERILE EMPTYING UNIT OF A FINAL ELEMENTARY CONTAINER WITH BIOPHARMACEUTICAL DOMAIN CONTENT

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4865583A (en) * 1987-05-04 1989-09-12 Tu Ho C Combination blood sampling and intravenous infusion apparatus and method
WO1991000217A1 (en) * 1989-06-29 1991-01-10 E.I. Du Pont De Nemours And Company Process for sterile addition of additives
US5322773A (en) * 1988-07-20 1994-06-21 Meiji Milk Products Co., Ltd. Selective enzymatic degradation of β-lactoglobulin contained in cow's milk-serum protein
US5356378A (en) * 1992-01-22 1994-10-18 Ivac Corporation Fluid line condition detection
US5385540A (en) * 1993-05-26 1995-01-31 Quest Medical, Inc. Cardioplegia delivery system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4865583A (en) * 1987-05-04 1989-09-12 Tu Ho C Combination blood sampling and intravenous infusion apparatus and method
US5322773A (en) * 1988-07-20 1994-06-21 Meiji Milk Products Co., Ltd. Selective enzymatic degradation of β-lactoglobulin contained in cow's milk-serum protein
WO1991000217A1 (en) * 1989-06-29 1991-01-10 E.I. Du Pont De Nemours And Company Process for sterile addition of additives
US5356378A (en) * 1992-01-22 1994-10-18 Ivac Corporation Fluid line condition detection
US5385540A (en) * 1993-05-26 1995-01-31 Quest Medical, Inc. Cardioplegia delivery system

Also Published As

Publication number Publication date
CN1168656A (en) 1997-12-24
AU3416195A (en) 1996-03-22

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