WO1995033745A3 - Novel compounds useful in modulating gene expression of retinoid responsive genes and/or having anti-ap-1 activity - Google Patents

Novel compounds useful in modulating gene expression of retinoid responsive genes and/or having anti-ap-1 activity Download PDF

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Publication number
WO1995033745A3
WO1995033745A3 PCT/US1995/007390 US9507390W WO9533745A3 WO 1995033745 A3 WO1995033745 A3 WO 1995033745A3 US 9507390 W US9507390 W US 9507390W WO 9533745 A3 WO9533745 A3 WO 9533745A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene expression
activity
novel compounds
compounds useful
responsive genes
Prior art date
Application number
PCT/US1995/007390
Other languages
French (fr)
Other versions
WO1995033745A9 (en
WO1995033745A2 (en
Inventor
Magnus Pfahl
Mi-Ock Lee
Marcia I Dawson
Peter D Hobbs
Andrea Fanjul
Ling Jong
Gerhart Graupner
Xian-Ping Lu
Original Assignee
Stanford Res Inst Int
Jolla Cancer Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int, Jolla Cancer Res Found filed Critical Stanford Res Inst Int
Priority to AU28233/95A priority Critical patent/AU2823395A/en
Publication of WO1995033745A2 publication Critical patent/WO1995033745A2/en
Publication of WO1995033745A9 publication Critical patent/WO1995033745A9/en
Publication of WO1995033745A3 publication Critical patent/WO1995033745A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings

Abstract

Novel compounds are provided which are useful for the regulation of gene expression by retinoids; these compounds are represented by structural formula (I), wherein the substituents R1 through R5 are as defined herein. Additional compounds are provided which are useful for selectively inhibiting AP-1 or an AP-1 component; one group of such compounds is exemplified by structural formula (II), wherein the substituents R?1, R2, R20, R21, R22 and R23¿ are defined herein. Pharmaceutical compositions are provided as well, as are methods of using the compounds in a variety of contexts.
PCT/US1995/007390 1994-06-07 1995-06-07 Novel compounds useful in modulating gene expression of retinoid responsive genes and/or having anti-ap-1 activity WO1995033745A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU28233/95A AU2823395A (en) 1994-06-07 1995-06-07 Novel compounds useful in modulating gene expression of retinoid responsive genes and/or having anti-ap-1 activity

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US25534594A 1994-06-07 1994-06-07
US08/255,345 1994-06-07
US32677594A 1994-10-20 1994-10-20
US08/326,775 1994-10-20
US46803595A 1995-06-06 1995-06-06
US08/468,035 1995-06-06

Publications (3)

Publication Number Publication Date
WO1995033745A2 WO1995033745A2 (en) 1995-12-14
WO1995033745A9 WO1995033745A9 (en) 1996-01-18
WO1995033745A3 true WO1995033745A3 (en) 1996-05-02

Family

ID=27400851

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/007390 WO1995033745A2 (en) 1994-06-07 1995-06-07 Novel compounds useful in modulating gene expression of retinoid responsive genes and/or having anti-ap-1 activity

Country Status (2)

Country Link
AU (1) AU2823395A (en)
WO (1) WO1995033745A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7329741B2 (en) * 1996-06-05 2008-02-12 Chiron Corporation Polynucleotides that hybridize to DP-75 and their use
DE69728986T2 (en) * 1996-06-21 2005-04-07 Allergan, Inc., Irvine SUBSTITUTED TETRAHYDRONAPHTHALIN AND DIHYDRONAPHTHALINE DERIVATIVES WITH A RETINOID AND / OR RETINOID ANTAGONIST-RELATED BIOLOGICAL ACTIVITY
FR2752734B1 (en) * 1996-09-02 1998-11-06 Cird Galderma USE OF RETINOIDS FOR THE PREPARATION OF A MEDICAMENT FOR TREATING CONDITIONS RELATED TO VEGF OVEREXPRESSION
DE19708461A1 (en) * 1997-02-18 1998-08-27 Meulen Volker Prof Dr Ter Use of aminergic substances to prepare medicaments
EP1030662B1 (en) * 1997-11-12 2006-08-02 F. Hoffmann-La Roche Ag Treatment of t-helper cell type 2 mediated immune diseases with retinoid antagonists
WO2002028810A2 (en) 2000-10-02 2002-04-11 F. Hoffmann-La Roche Ag Retinoids for the treatment of emphysema
US20040131648A1 (en) * 2002-10-24 2004-07-08 The Procter & Gamble Company Nuclear hormone receptor compounds, products and methods employing same
JP2009536660A (en) 2006-05-02 2009-10-15 アナコール ファーマシューティカルズ，インコーポレイテッド Hydrolysis-resistant boron-containing therapeutic agent and method of use thereof
KR101587687B1 (en) * 2012-04-27 2016-01-21 가톨릭대학교 산학협력단 Composition for preventing or treating immune disease comprising SR11302

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0210929A2 (en) * 1985-07-25 1987-02-04 Centre International De Recherches Dermatologiques Galderma - Cird Galderma Aromatic polycyclic derivatives, process for their preparation and their pharmaceutical and cosmetic use
US4833240A (en) * 1986-07-17 1989-05-23 Centre International De Recherches Dermatologiques (Cird) Bicyclic aromatic derivatives, method for preparing them, and their use in human and veterinary medicine and in cosmetics
WO1992007072A1 (en) * 1990-10-10 1992-04-30 La Jolla Cancer Research Foundation Method of inhibiting transcription utilizing nuclear receptors
WO1993021146A1 (en) * 1992-04-22 1993-10-28 Ligand Pharmaceuticals Incorporated Compounds having selectivity for retinoid x receptors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0210929A2 (en) * 1985-07-25 1987-02-04 Centre International De Recherches Dermatologiques Galderma - Cird Galderma Aromatic polycyclic derivatives, process for their preparation and their pharmaceutical and cosmetic use
US4833240A (en) * 1986-07-17 1989-05-23 Centre International De Recherches Dermatologiques (Cird) Bicyclic aromatic derivatives, method for preparing them, and their use in human and veterinary medicine and in cosmetics
WO1992007072A1 (en) * 1990-10-10 1992-04-30 La Jolla Cancer Research Foundation Method of inhibiting transcription utilizing nuclear receptors
WO1993021146A1 (en) * 1992-04-22 1993-10-28 Ligand Pharmaceuticals Incorporated Compounds having selectivity for retinoid x receptors

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DAWSON ET AL.: "Effect of structural modifications ...", J. MED. CHEM., vol. 32, pages 1504 - 1517 *
FANJUL ET AL.: "A new class of retinoids with ...", NATURE, vol. 372, 3 November 1994 (1994-11-03), pages 107 - 111 *
KAGECHIKA ET AL.: "Retionbenzoic acids ...", J. MED. CHEM., vol. 32, pages 1098 - 1108 *
LEHMANN ET AL.: "Identification of Retinoids ...", CANCER RESEARCH, vol. 51, pages 4804 - 4809 *
LEHMANN ET AL.: "Retinoids selective for ...", SCIENCE, vol. 258, pages 1944 - 1946 *
PFAHL: "Nuclear Receptor/AP-1 Interaction", ENDOCRINE REVIEWS, vol. 14, no. 5, pages 651 - 658 *

Also Published As

Publication number Publication date
AU2823395A (en) 1996-01-04
WO1995033745A2 (en) 1995-12-14

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