WO1995031541A3 - Methods and compositions for treatment of restenosis and cancer using ribozymes - Google Patents

Methods and compositions for treatment of restenosis and cancer using ribozymes Download PDF

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Publication number
WO1995031541A3
WO1995031541A3 PCT/US1995/006368 US9506368W WO9531541A3 WO 1995031541 A3 WO1995031541 A3 WO 1995031541A3 US 9506368 W US9506368 W US 9506368W WO 9531541 A3 WO9531541 A3 WO 9531541A3
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WO
WIPO (PCT)
Prior art keywords
ribozymes
restenosis
cancer
compositions
treatment
Prior art date
Application number
PCT/US1995/006368
Other languages
French (fr)
Other versions
WO1995031541A2 (en
Inventor
Dan T Stinchcomb
Kenneth Draper
James Mcswiggen
Thale Jarvis
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Ribozyme Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribozyme Pharm Inc filed Critical Ribozyme Pharm Inc
Priority to AU26422/95A priority Critical patent/AU2642295A/en
Priority to MX9605716A priority patent/MX9605716A/en
Priority to JP7529908A priority patent/JPH10500309A/en
Priority to EP95921311A priority patent/EP0763106A1/en
Priority to CA002190513A priority patent/CA2190513A1/en
Publication of WO1995031541A2 publication Critical patent/WO1995031541A2/en
Publication of WO1995031541A3 publication Critical patent/WO1995031541A3/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
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    • C12N2310/10—Type of nucleic acid
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    • C12N2310/3517—Marker; Tag

Abstract

An enzymatic nucleic acid molecule which cleaves c-myb RNA, wherein the binding arms of said nucleic acid contain sequences complementary to the sequences defined in Tables II, XII-XXIV.
PCT/US1995/006368 1994-05-18 1995-05-18 Methods and compositions for treatment of restenosis and cancer using ribozymes WO1995031541A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU26422/95A AU2642295A (en) 1994-05-18 1995-05-18 Methods and compositions for treatment of restenosis and cancer using ribozymes
MX9605716A MX9605716A (en) 1994-05-18 1995-05-18 Methods and compositions for treatment of restenosis and cancer using ribozymes.
JP7529908A JPH10500309A (en) 1994-05-18 1995-05-18 Methods and compositions for treating restenosis and cancer using ribozymes
EP95921311A EP0763106A1 (en) 1994-05-18 1995-05-18 Methods and compositions for treatment of restenosis and cancer using ribozymes
CA002190513A CA2190513A1 (en) 1994-05-18 1995-05-18 Methods and compositions for treatment of restenosis and cancer using ribozymes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24546694A 1994-05-18 1994-05-18
US08/245,466 1994-05-18
US08/373,124 US5646042A (en) 1992-08-26 1995-01-13 C-myb targeted ribozymes
US08/373,124 1995-01-13

Publications (2)

Publication Number Publication Date
WO1995031541A2 WO1995031541A2 (en) 1995-11-23
WO1995031541A3 true WO1995031541A3 (en) 1996-04-25

Family

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PCT/US1995/006368 WO1995031541A2 (en) 1994-05-18 1995-05-18 Methods and compositions for treatment of restenosis and cancer using ribozymes

Country Status (7)

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US (2) US5646042A (en)
EP (1) EP0763106A1 (en)
JP (1) JPH10500309A (en)
AU (1) AU2642295A (en)
CA (1) CA2190513A1 (en)
MX (1) MX9605716A (en)
WO (1) WO1995031541A2 (en)

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